WO2020093172A1 - Ventricular deployment of a transcatheter mitral valve prosthesis - Google Patents

Ventricular deployment of a transcatheter mitral valve prosthesis Download PDF

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Publication number
WO2020093172A1
WO2020093172A1 PCT/CA2019/051598 CA2019051598W WO2020093172A1 WO 2020093172 A1 WO2020093172 A1 WO 2020093172A1 CA 2019051598 W CA2019051598 W CA 2019051598W WO 2020093172 A1 WO2020093172 A1 WO 2020093172A1
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WO
WIPO (PCT)
Prior art keywords
tab
anterior
ventricular
distal
capsule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2019/051598
Other languages
English (en)
French (fr)
Inventor
Eric Soun-Sang FUNG
Kathleen HUNG
Karen Tsoek-Ji Wong
David Andrew MOFFATT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neovasc Tiara Inc
Original Assignee
Neovasc Tiara Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neovasc Tiara Inc filed Critical Neovasc Tiara Inc
Priority to JP2021524365A priority Critical patent/JP7260930B2/ja
Priority to EP19883080.4A priority patent/EP3876870B1/en
Priority to AU2019374743A priority patent/AU2019374743B2/en
Priority to CA3118599A priority patent/CA3118599C/en
Priority to CN201980088422.XA priority patent/CN113271890B/zh
Publication of WO2020093172A1 publication Critical patent/WO2020093172A1/en
Anticipated expiration legal-status Critical
Priority to AU2022203596A priority patent/AU2022203596B2/en
Priority to JP2023057807A priority patent/JP7507281B2/ja
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A61F2/243—Deployment by mechanical expansion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A61F2/2436—Deployment by retracting a sheath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body

Definitions

  • the heart of vertebrate animals is divided into four chambers, and is equipped with four valves (the mitral, aortic, pulmonary and tricuspid valves) that ensure that blood pumped by the heart flows in a forward direction through the cardiovascular system.
  • the mitral valve of a healthy heart prevents the backflow of blood from the left ventricle into the left atrium of the heart and comprises two flexible leaflets (anterior and posterior) that close when the left ventricle contracts.
  • the leaflets are attached to a fibrous annulus, and their free edges are tethered by subvalvular chordae tendineae to papillary muscles in the left ventricle to prevent them from prolapsing into the left atrium during the contraction of the left ventricle.
  • Various cardiac diseases or degenerative changes may cause dysfunction in any of these portions of the mitral valve apparatus, causing the mitral valve to become abnormally narrowed or dilated, or to allow blood to leak (i.e. regurgitate) from the left ventricle back into the left atrium. Any such impairments compromise cardiac sufficiency and can be debilitating or life threatening.
  • a prosthetic valve is generally mounted in a crimped state on the end of a flexible catheter and advanced through a blood vessel or the body of the patient until the valve reaches the implantation site. The prosthetic valve is then expanded to its functional size at the site of the defective native valve.
  • Patents and publications which may be related include but are not limited to: PCT Publication Nos. W02008/103722, W02009/134701, and WO2011/137531.
  • Other patent and publications which may be related but are not limited to, include: U.S. Patent Publication Nos. US2007/0016286,
  • FIG. 1 is a schematic illustration of the left ventricle of a heart showing blood flow during systole with arrows.
  • Fig. 2 is a schematic illustration of the left ventricle of a heart having prolapsed leaflets in the mitral valve.
  • FIG. 3 is a schematic illustration of a heart in a patient suffering from cardiomyopathy where the heart is dilated and the leaflets do not meet.
  • Fig. 3A shows normal closure of the valve leaflets.
  • Fig. 3B shows abnormal closure of the valve leaflets.
  • Fig. 4 illustrates mitral valve regurgitation in the left ventricle of a heart having impaired papillary muscles.
  • Figs. 5A-5B illustrate anatomy of the mitral valve.
  • Fig. 6 illustrates an uncovered frame in a prosthetic cardiac valve, with the frame flattened out and unrolled.
  • Fig. 7 illustrates another an uncovered frame in a prosthetic cardiac valve, with the frame flattened out and unrolled.
  • FIG. 8 illustrates still another uncovered frame in a prosthetic cardiac valve, with the frame flattened out and unrolled.
  • Fig. 9A illustrates a perspective view of an uncovered frame in a prosthetic cardiac valve after it has expanded.
  • Fig. 9B illustrates a top view of the structure in Fig. 9A.
  • Fig. 10 illustrates the frame of Fig. 9A with the covering thereby forming a prosthetic cardiac valve.
  • FIGs. 11 A- 11 D illustrate a delivery system used to transapically deliver a prosthetic cardiac valve.
  • Figs. 12A-12L illustrates a method of implanting a prosthetic cardiac valve.
  • Figs. 13A-13L illustrates another method of implanting a prosthetic cardiac valve.
  • Figs. 14A-14D illustrate a tab covering.
  • FIGS. 15A-15E schematically illustrates a method of deploying a prosthetic cardiac valve whereby the first and second anterior tabs are concurrently deployed, according to many examples.
  • FIGS. 15F-15L schematically illustrate a method of deploying a prosthetic cardiac valve whereby the first anterior tab is deployed before the second anterior tab, according to many examples.
  • FIG. 16A shows a prosthetic cardiac valve held within a constraining sheath, according to many examples.
  • FIG. 16B schematically illustrates a cross-section of the prosthetic cardiac valve of FIG. 16A taken along line B-B of FIG. 16B.
  • FIGS. 17A-17M schematically illustrate variations of different sequences for fully deploying a first anterior tab, a second anterior tab, and a posterior tab of a prosthetic cardiac valve, according to many examples.
  • FIGS. 18A-18M schematically illustrate variations of different sequences for partially deploying a first anterior tab, a second anterior tab, and a posterior tab of a prosthetic cardiac valve, according to many examples.
  • FIGS. 19A-19D illustrate a sequence of deployment of a prosthetic valve.
  • FIGS. 20A-20E illustrate another sequence of deployment of a prosthetic valve.
  • FIGS. 21 A-21E illustrate still another sequence of deployment of a prosthetic valve.
  • FIGS. 22A-22B illustrate an example of tab deployment.
  • FIGS. 23A-23C illustrate yet another example of deployment of a prosthetic valve.
  • FIGS. 24A-24C illustrate a delivery system for a prosthetic valve.
  • FIGS. 25A-25C illustrate another delivery system for a prosthetic valve.
  • FIGS. 25D1-25D2 show an example of a capsule.
  • FIGS. 25E1-25E2 show another example of a capsule.
  • FIGS. 25F1-25F2 show still another example of a capsule.
  • FIGS. 25G-25H show an example of ventricular deployment.
  • FIG. 251 shows an example of a mechanism for controlling deployment.
  • FIG. 25J illustrates an example of controlling deployment.
  • FIG. 26 is a perspective view of a transseptal delivery system for a prosthetic heart valve.
  • FIGS. 27A-27D illustrate an example of a transseptal method of delivering a prosthetic valve.
  • FIG. 28 is an assembly view of the delivery system seen in FIG.
  • FIG. 29 is an assembly view of the delivery handle portion of the delivery system seen in FIG. 26.
  • FIG. 30 is an assembly view of the steering guide portion of the delivery system seen in FIG. 26.
  • FIG. 31 is an assembly view of the delivery catheter portion of the delivery system seen in FIG 26.
  • valves such as aortic valves, pulmonary valves, tricuspid valves, or even other valves such as venous valves.
  • a prosthetic valve is generally mounted in a crimped state on the end of a flexible catheter and advanced through a blood vessel or the body of the patient until the valve reaches the implantation site. The prosthetic valve is then expanded to its functional size at the site of the defective native valve.
  • FIG. 1 Cardiac Anatomy.
  • the left ventricle LV of a normal heart H in systole is illustrated in Fig. 1.
  • the left ventricle LV is contracting and blood flows outwardly through the aortic valve AV, a tricuspid valve in the direction of the arrows.
  • Back flow of blood or "regurgitation" through the mitral valve MV is prevented since the mitral valve is configured as a "check valve” which prevents back flow when pressure in the left ventricle is higher than that in the left atrium LA.
  • the mitral valve MV comprises a pair of leaflets having free edges FE which meet evenly to close, as illustrated in Fig. 1.
  • the opposite ends of the leaflets LF are attached to the surrounding heart structure along an annular region referred to as the annulus AN.
  • the free edges FE of the leaflets LF are secured to the lower portions of the left ventricle LV through chordae tendineae CT (also referred to herein as the chordae) which include a plurality of branching tendons secured over the lower surfaces of each of the valve leaflets LF.
  • the chordae CT in turn, are attached to the papillary muscles PM which extend upwardly from the lower portions of the left ventricle and interventricular septum I VS.
  • a number of structural defects in the heart can cause mitral valve regurgitation.
  • Ruptured chordae RCT as shown in Fig. 2, can cause a valve leaflet LF2 to prolapse since inadequate tension is transmitted to the leaflet via the chordae.
  • the other leaflet LF1 maintains a normal profile, the two valve leaflets do not properly meet and leakage from the left ventricle LV into the left atrium LA will occur, as shown by the arrow.
  • Regurgitation also occurs in the patients suffering from cardiomyopathy where the heart is dilated and the increased size prevents the valve leaflets LF from meeting properly, as shown in Fig. 3.
  • the enlargement of the heart causes the mitral annulus to become enlarged, making it impossible for the free edges FE to meet during systole.
  • the free edges of the anterior and posterior leaflets normally meet along a line of coaptation C as shown in Fig.
  • Mitral valve regurgitation can also occur in patients who have suffered ischemic heart disease where the functioning of the papillary muscles PM is impaired, as illustrated in Fig. 4. As the left ventricle LV contracts during systole, the papillary muscles PM do not contract sufficiently to effect proper closure. The leaflets LF1 and LF2 then prolapse, as illustrated. Leakage again occurs from the left ventricle LV to the left atrium LA, as shown by the arrow.
  • Fig. 5A more clearly illustrates the anatomy of a mitral valve MV which is a bicuspid valve having an anterior side ANT and a posterior side POST.
  • the valve includes an anterior (aortic) leaflet AL and a posterior (mural) leaflet PL.
  • Chordae tendineae CT couple the valve leaflets AL, PL with the antero-lateral papillary muscle ALPM and the postero-medial papillary muscle PMPM.
  • the valve leaflets AL, PL join one another along a line referred to as the antero-lateral commissure ALC and the posterior-medial commissure PMC.
  • the annulus AN circumscribes the valve leaflets, and two regions adjacent an anterior portion of the annulus, on opposite sides of the anterior leaflet are referred to as the left fibrous trigone LFT and also the right fibrous trigone RFT. These areas are indicted generally by the solid triangles.
  • Fig. 5B more clearly illustrates the left and right fibrous trigones, LFT, RFT.
  • Prosthetic Valve Prosthetic valves have been surgically implanted in the heart as a treatment for mitral regurgitation. Some of these valves have been valves harvested from animals such as porcine valves, and others have been prosthetic mechanical valves with or without a tissue covering. More recently, minimally invasive catheter technology has been used to deliver prosthetic valves to the heart. These valves typically include an anchor for securing the valve to the patient's heart, and a valve mechanism, either a mechanical valve, a valve with animal tissue, or combinations thereof. The prosthetic valve once implanted, takes over for the malfunctioning native valve, thereby reducing or eliminating valvar insufficiency. While some of these valves appear promising, there still is a need for improved valves. Positioning and anchoring the prosthetic valve in the native anatomy remains a challenge. The following specification discloses a prosthetic valve, a delivery system for the prosthetic valve, and methods of delivering the valve that overcome some of the challenges associated with existing prosthetic valves.
  • Fig. 6 illustrates a prosthetic cardiac valve in the cut and unrolled flat pattern. Coverings from the frame (e.g. fabric or tissue) have been removed to permit observation of the underlying frame 600. The frame has been unrolled and flattened out.
  • the prosthetic valve frame 600 has an atrial region 606, an annular region 608, and a ventricular region 610.
  • the frame 600 is formed from a plurality of interconnected struts that form a series of peaks and valleys which can expand and contract relative to one another thereby permitting the frame to be loaded onto a delivery catheter in a collapsed configuration, and then radially expanded at a target treatment site for implantation.
  • the frame is self-expanding and may be fabricated using superelastic nitinol or other self-expanding materials. Shape memory alloys that spring open above a transition temperature may also be used, and expandable members may also be used to expand the frame when plastic deformation (e.g. balloon expansion) is required to open the frame.
  • Atrial region 606 has a skirt 616 which includes a plurality of interconnected struts that form a series of peaks and valleys. In this region, the struts are skewed relative to one another and thus the resulting cell pattern has an enlarged end and the opposite end tapers to a smaller end.
  • the anterior portion of the atrial skirt does not have a flanged region like the posterior portion, thus the anterior portion 602 of the atrial region may have shorter stmts than the posterior region 604.
  • the peaks and valleys in the anterior portion are axially offset from those in the remaining posterior portion of the atrial region.
  • the shortened stmts and offset peaks and valleys form an alignment element 614 that can assist the physician with visualization of delivery of the prosthetic valve to the mitral valve and with alignment of the prosthetic valve prior to expansion of the prosthetic valve.
  • Optional radiopaque markers 614a are disposed on either side of the offset peaks and valleys and further help with visualization during implantation of the valve.
  • the atrial region preferably self-expands to either a cylindrical shape, or it may have a D-shaped cross-section where the anterior portion 602 is substantially flat, and the posterior portion 604 is cylindrically shaped.
  • This allows the atrial skirt to conform to the anatomy of the native mitral valve, thereby preventing obstmction of the left ventricular outflow tract.
  • the atrial skirt may also be formed so that upon expansion, the skirt flares outward and forms a flange that can rest against a superior surface of the mitral valve.
  • the flanged region is preferably along the posterior portion of the atrial skirt, and the anterior portion of the atrial skirt remains flangeless. Or, the flange may extend entirely around the atrial skirt.
  • the atrial region is connected to the adjacent annular region 608 with connecting stmts which are preferably linear and substantially parallel to the longitudinal axis of the frame.
  • the annular region 608 is also comprised of a plurality of axially oriented and interconnected stmts that form peaks and valleys that allow radial expansion.
  • the stmts are preferably parallel with one another and parallel with the longitudinal axis of the frame.
  • the annular region may also be self expanding and expand into a cylindrical shape, or more preferably the annular region may expand to have a D-shaped cross-section as described above with respect to the atrial region.
  • the annular region may similarly have a flat anterior portion, and a cylindrically shaped posterior portion.
  • Connector stmts join the annular region with the ventricular region 610.
  • the ventricular region 610 also includes a plurality of interconnected stmts that form peaks and valleys. Additionally, the stmts in the ventricular region form the leaflet commissures 613 which are covered with fabric, pericardial tissue, or other materials to form the prosthetic valve leaflets. Holes in the commissures allow suture to be attached thereto. Stmts in the ventricular region also form a ventricular skirt 628 which expands outward to engage the anterior and posterior mitral valve leaflets, and stmts in the ventricular region also form the anterior tabs 624 and the posterior tab 630. The anterior tabs are designed to capture the anterior mitral valve leaflet between an inner surface of the anterior tab and outer surface of the ventricular skirt.
  • any adjacent chordae tendineae may also be captured therebetween.
  • the tip of the anterior tab engages the fibrous trigone on an anterior portion of the mitral valve, one on the left and one on the right side.
  • the posterior tab similarly captures the posterior mitral valve leaflet between an inner surface of the posterior tab and an outer surface of the ventricular skirt, along with any adjacent chordae tendineae. This will be described in more detail below.
  • the sequence of the deployment of the tabs may be controlled.
  • the anterior and posterior tabs will partially spring outward together.
  • the constraining sheath is further retracted, the remainder of the anterior tabs will self-expand radially outward. Further retraction of the constraining sheath then allows the remainder of the posterior tab to finish its radial expansion, and finally the ventricular skirt will radially expand outward.
  • strut lengths and axial position of the posterior tab and the ventricular skirt are similar, internal struts connect the ventricular skirt with the
  • the posterior tab finishes expansion before the ventricular skirt.
  • Using this sequence of deploying the prosthetic valve may allow the valve to more accurately be delivered and more securely anchored into position.
  • either the anterior tab(s) or the posterior tab(s) may be more easily visualized than the other in at least some cases, and the more easily visualized tab may be configured to deploy first as a guide to orient the frame during implantation.
  • the posterior tab is easier to visualize using ultrasound and/or fluoroscopy.
  • the sequence of tab deployment may be customized to the individual patient and their anatomy in some cases and the customization may be based on pre-screening imaging data for the individual patient.
  • the tabs that are projected to be more easily visualized may be configured to deploy first.
  • the initially deployed tabs can allow for intermediate movement of the imaging source, e.g., the C-arm controlling the ultrasound or X-ray device for fluoroscopy, so as to provide verification of the initial tab placements.
  • the prosthetic valve may be repositioned and/or reoriented with the initial tab(s) deployed (and the remaining tab(s) yet to be deployed) based on the imaging or visualization.
  • the length and/or curvature of one or more of the tabs may be customized for the individual patient and their anatomy.
  • the length and/or curvature of the one or more tabs may be customized to provide an optimum fit for the individual patient’s anatomy, such as the deployment area behind the valve leaflet(s) and/or the chordae tendinae.
  • Suture holes 621 are disposed along the stmts of the annular region as well as the ventricular region to allow attachment of a cover such as pericardium or a polymer such as Dacron or ePTFE.
  • the suture holes may also be disposed along any other part of the frame.
  • Barbs 623 are disposed along the ventricular skirt 628 to help anchor the prosthetic valve to adjacent tissue.
  • Commissure tabs or tabs 612 are disposed on the tips of the commissures 613 and may be used to releasably couple the commissures with a delivery system as will be described below. This allows the frame to expand first, and then the commissures may be released from the delivery system afterwards.
  • a number of stmt geometries may be used, and additionally that stmt dimensions such as length, width, thickness, etc. may be adjusted in order to provide the prosthesis with the desired mechanical properties such as stiffness, radial cmsh strength, commissure deflection, etc. Therefore, the illustrated geometry is not intended to be limiting.
  • the frame may be formed by electrical discharge machining
  • EDM electrospray etching
  • Elypodermic tubing or flat sheets may be used to form the frame.
  • the frame Once the frame has been cut and formed into a cylinder (if required), it may be radially expanded into a desired geometry and heat treated using known processes to set the shape.
  • the prosthetic valve may be loaded onto a delivery catheter in a collapsed configuration and constrained in the collapsed configuration with a constraining sheath. Removal of the constraining sheath will allow the prosthesis to self-expand into its unbiased pre-set shape.
  • an expandable member such as a balloon may be used to radially expand the prosthesis into its expanded configuration.
  • FIG. 7 illustrates another example of a prosthetic cardiac valve in the flat and unrolled cut pattern, and similar to the previous example with the major difference being the strut lengths in the anterior tabs, posterior tab, and ventricular skirt. Varying the strut lengths allow the sequence of expansion of the anterior and posterior tabs and ventricular skirt to be controlled. Coverings from the frame (e.g. fabric or tissue) has been removed to permit observation of the underlying frame 700. The frame has been unrolled and flattened out.
  • the prosthetic valve frame 700 has an atrial region 706, an annular region 708, and a ventricular region 710.
  • the frame 700 is formed from a plurality of interconnected struts that form a series of peaks and valleys which can expand and contract relative to one another thereby permitting the frame to be loaded onto a delivery catheter in a collapsed configuration, and then radially expanded at a target treatment site for implantation.
  • Some examples are self-expanding and may be fabricated using superelastic nitinol or other self-expanding materials. Shape memory alloys that spring open above a transition temperature may also be used, and expandable members may also be used to expand the frame when plastic deformation (e.g. balloon expansion) is required to open the frame.
  • Atrial region 706 has a skirt 716 which includes a plurality of interconnected struts that form a series of peaks and valleys. In this region, the struts are skewed relative to one another and thus the resulting cell pattern has an enlarged end and the opposite end tapers to a smaller end.
  • An anterior portion 702 of the atrial region has shorter stmts than the posterior region 704. Thus, the peaks and valleys in the anterior portion are axially offset from those in the remaining posterior portion of the atrial region. This allows creation of an alignment element 714 to help the physician deliver the prosthetic valve to the mitral valve and align the prosthetic valve prior to expansion of the prosthetic valve.
  • Atrial region 706 Other aspects of the atrial region 706 are similar to those of the atrial region 606 in Fig. 6.
  • Optional radiopaque markers 7l4a are disposed on either side of the offset peaks and valleys and help with visualization during implantation of the valve.
  • the atrial region preferably self-expands to either a cylindrical shape, or it may have a D-shaped cross-section where the anterior portion 702 is substantially flat, and the posterior portion 704 is cylindrically shaped. This allows the atrial skirt to conform to the anatomy of the native mitral valve, thereby preventing obstruction of the left ventricular outflow tract. Additionally, the atrial skirt may also be formed so that upon expansion, the skirt flares outward and forms a flange that can rest against a superior surface of the mitral valve.
  • the flanged region is preferably along the posterior portion of the atrial skirt, and the anterior portion of the atrial skirt remains flangeless. Or, the flange may extend entirely around the atrial skirt.
  • the atrial region is connected to the adjacent annular region 708 with connecting struts which are preferably linear and substantially parallel to the longitudinal axis of the frame.
  • the annular region 708 is also comprised of a plurality of axially oriented and interconnected stmts that form peaks and valleys that allow radial expansion.
  • the stmts are preferably parallel with one another and parallel with the longitudinal axis of the frame.
  • the annular region may also be self expanding and expand into a cylindrical shape, or more preferably the annular region may expand to have a D-shaped cross-section as described above with respect to the atrial region.
  • the annular region may similarly have a flat anterior portion, and a cylindrically shaped posterior portion.
  • Connector stmts join the annular region with the ventricular region 710.
  • the ventricular region 710 also includes a plurality of interconnected stmts that form peaks and valleys. Additionally, the stmts in the ventricular region form the leaflet commissures 713 which are covered with fabric, pericardial tissue, or other materials to form the prosthetic valve leaflets. Holes in the commissures allow suture to be attached thereto. Stmts in the ventricular region also form a ventricular skirt 728 which expands outward to engage the anterior and posterior mitral valve leaflets, and stmts in the ventricular region also form the anterior tabs 724 and the posterior tab 730. The anterior tabs are designed to capture the anterior mitral valve leaflet between an inner surface of the anterior tab and outer surface of the ventricular skirt.
  • any adjacent chordae tendineae may also be captured therebetween.
  • the tip of the anterior tab engages the fibrous trigone on an anterior portion of the mitral valve, one on the left and one on the right side.
  • the posterior tab similarly captures the posterior mitral valve leaflet between an inner surface of the posterior tab and an outer surface of the ventricular skirt, along with any adjacent chordae tendineae. This will be described in more detail below.
  • stmt length or axial position of the anterior or posterior tabs along the frame deployment of the tabs may be controlled.
  • the length of the stmts in the anterior tabs and posterior tabs 724, 730 as well as their relative position along the frame are the same as one another, when a constraining sheath is retracted away from the tabs, the anterior and posterior tabs will partially spring outward together. As the constraining sheath is further retracted, the remainder of the anterior tabs will self-expand radially outward because they are the shortest relative to the struts in the ventricular skirt and the posterior tab.
  • Suture holes 721 are disposed along the stmts of the annular region as well as the ventricular region to allow attachment of a cover such as pericardium or a polymer such as Dacron or ePTFE.
  • the suture holes may also be disposed along any other part of the frame.
  • Barbs 723 are disposed along the ventricular skirt 728 to help anchor the prosthetic valve to adjacent tissue.
  • Commissure tabs or tabs 712 are disposed on the tips of the commissures 713 and may be used to releasably couple the commissures with a delivery system as will be described below. This allows the frame to expand first, and then the commissures may be released from the delivery system afterwards.
  • a number of stmt geometries may be used, and additionally that stmt dimensions such as length, width, thickness, etc. may be adjusted in order to provide the prosthesis with the desired mechanical properties such as stiffness, radial cmsh strength, commissure deflection, etc. Therefore, the illustrated geometry is not intended to be limiting.
  • the frame may be formed similarly as described above with respect to Fig. 6.
  • Fig. 8 illustrates another form of a prosthetic cardiac valve in the flat, unrolled cut pattern, and is similar to the previous examples, with the major difference being that the posterior tab is designed to expand to form an elongate horizontal section which allows engagement and anchoring of the posterior tab with the sub-annular region between the posterior leaflet and the ventricular wall.
  • the elongate horizontal section contacts a larger region of the sub- annular region as compared with a posterior tab that only has a tapered tip formed from a single hinge between stmts. This provides enhanced anchoring of the prosthetic valve.
  • the anterior tabs will completely self-expand first, followed by the posterior tab and then the ventricular skirt.
  • the frame 800 has an atrial region 806, an annular region 808, and a ventricular region 810.
  • the frame 800 is formed from a plurality of interconnected stmts that form a series of peaks and valleys which can expand and contract relative to one another thereby permitting the frame to be loaded onto a delivery catheter in a collapsed configuration, and then radially expanded at a target treatment site for implantation.
  • Examples are self expanding and may be fabricated using superelastic nitinol or other self expanding materials. Shape memory alloys that spring open above a transition temperature may also be used, and expandable members may also be used to expand the frame when plastic deformation (e.g. balloon expansion) is required to open the frame.
  • plastic deformation e.g. balloon expansion
  • Atrial region 806 has a skirt 816 which includes a plurality of interconnected stmts that form a series of peaks and valleys. In this region, the stmts are skewed relative to one another and thus the resulting cell pattern has an enlarged end and the opposite end tapers to a smaller end.
  • An anterior portion 802 of the atrial region has shorter stmts than the posterior region 804. Thus, the peaks and valleys in the anterior portion are axially offset from those in the remaining posterior portion of the atrial region. This allows creation of an alignment element 814 to help the physician deliver the prosthetic valve to the mitral valve and align the prosthetic valve prior to expansion of the prosthetic valve.
  • Atrial region 806 Other aspects of the atrial region 806 are similar to those of the atrial region 606 in Fig. 6.
  • Optional radiopaque markers 8l4a are disposed on either side of the offset peaks and valleys and help with visualization during implantation of the valve.
  • the atrial region preferably self-expands to either a cylindrical shape, or it may have a D-shaped cross-section where the anterior portion 802 is substantially flat, and the posterior portion 804 is cylindrically shaped. This allows the atrial skirt to conform to the anatomy of the native mitral valve, thereby preventing obstruction of the left ventricular outflow tract. Additionally, the atrial skirt may also be formed so that upon expansion, the skirt flares outward and forms a flange that can rest against a superior surface of the mitral valve.
  • the flanged region is preferably along the posterior portion of the atrial skirt, and the anterior portion of the atrial skirt remains flangeless. Or, the flange may extend entirely around the atrial skirt.
  • the atrial region is connected to the adjacent annular region 808 with connecting struts which are preferably linear and substantially parallel to the longitudinal axis of the frame.
  • the annular region 808 is also comprised of a plurality of axially oriented and interconnected stmts that form peaks and valleys that allow radial expansion.
  • the stmts are preferably parallel with one another and parallel with the longitudinal axis of the frame.
  • the annular region may also be self expanding and expand into a cylindrical shape, or more preferably the annular region may expand to have a D-shaped cross-section as described above with respect to the atrial region.
  • the annular region may similarly have a flat anterior portion, and a cylindrically shaped posterior portion.
  • Connector stmts join the annular region with the ventricular region 810.
  • the ventricular region 810 also includes a plurality of interconnected stmts that form peaks and valleys. Additionally, the stmts in the ventricular region form the leaflet commissures 813 which are covered with fabric, pericardial tissue, or other materials to form the prosthetic valve leaflets. Holes in the commissures allow suture to be attached thereto. Stmts in the ventricular region also form a ventricular skirt 828 which expands outward to engage the anterior and posterior mitral valve leaflets, and stmts in the ventricular region also form the anterior tabs 824 and the posterior tab 830. The anterior tabs are designed to capture the anterior mitral valve leaflet between an inner surface of the anterior tab and outer surface of the ventricular skirt.
  • the tip of the anterior tab engages the fibrous trigone on an anterior portion of the mitral valve, one on the left and one on the right side.
  • the posterior tab similarly captures the posterior mitral valve leaflet between an inner surface of the posterior tab and an outer surface of the ventricular skirt, along with any adjacent chordae tendineae. This will be described in more detail below.
  • the posterior tab is similar to the posterior tabs described above in Figs. 6-7, except that in this example, the posterior tab comprises four interconnected struts as opposed to two interconnected struts. Thus, in this example the plurality of interconnected struts contain three hinged regions 836 along the tab.
  • the hinged regions Upon expansion of the posterior tab, the hinged regions will also expand, thereby showing an elongate horizontal section which allows engagement and anchoring of the posterior tab with the sub-annular region between the posterior leaflet and the ventricular wall. This may help position and anchor the prosthetic valve better than posterior tabs which only have a smaller footprint or a single tapered tip for engagement with the posterior portion of the mitral valve.
  • the posterior tab may be substituted with any of the other posterior tabs described in this specification.
  • stmt length or axial position of the anterior or posterior tabs along the frame deployment of the tabs may be controlled.
  • the length of the stmts in the anterior tabs and posterior tabs 824, 830 as well as their relative position along the frame are the same as one another, when a constraining sheath is retracted away from the tabs, the anterior and posterior tabs will partially spring outward together. As the constraining sheath is further retracted, the remainder of the anterior tabs will self-expand radially outward because they are the shortest relative to the stmts in the ventricular skirt and the posterior tab.
  • Suture holes 821 are disposed along the stmts of the annular region as well as the ventricular region to allow attachment of a cover such as pericardium or a polymer such as Dacron or ePTFE.
  • the suture holes may also be disposed along any other part of the frame.
  • Barbs 823 are disposed along the ventricular skirt 828 to help anchor the prosthetic valve to adjacent tissue.
  • Commissure tabs or tabs 812 are disposed on the tips of the commissures 813 and may be used to releasably couple the commissures with a delivery system as will be described below. This allows the frame to expand first, and then the commissures may be released from the delivery system afterwards.
  • a number of stmt geometries may be used, and additionally stmt dimensions such as length, width, thickness, etc. may be adjusted in order to provide the prosthesis with the desired mechanical properties such as stiffness, radial cmsh strength, commissure deflection, etc. Therefore, the illustrated geometry is not intended to be limiting.
  • the frame may be shown similarly as described above.
  • Fig. 9A illustrates the frame 900 of a prosthetic cardiac valve after it has expanded. Any of the frame examples described above may take this form as each of the above frames have similar geometry but they expand in different order.
  • the frame includes the atrial skirt 906 with anterior portion 914 and posterior portion 916. A flanged region is disposed around the posterior portion and the anterior portion remains flangeless. Additionally, the anterior portion is generally flat, while the posterior portion is cylindrically shaped, thereby showing a D-shaped cross-section which accommodates the mitral valve anatomy.
  • Fig. 9B is a top view of the stmcture in Fig. 9A and more clearly illustrates the D-shaped cross-section.
  • the frame also includes the annular region 910 and ventricular skirt 912.
  • Anterior tabs 904 (only one visible in this view) is fully expanded such that a space exists between the inner surface of the anterior tab and an outer surface of the ventricular skirt. This allows the anterior leaflet and adjacent chordae to be captured therebetween.
  • the posterior tab 902 is also fully deployed, with a similar space between the inner surface of the posterior tab 902 and an outer surface of the ventricular skirt. This allows the posterior leaflet and adjacent chordae tendineae to be captured therebetween.
  • the commissure posts 908 are also visible and are disposed in the inner channel shown by the frame. The commissure posts are used to hold the prosthetic mitral valve leaflets.
  • the overall shape of the expanded frame is D-shaped, with the anterior portion flat and the posterior portion cylindrically shaped.
  • Fig. 10 illustrates the expanded frame covered with a cover 1002 such as pericardial tissue or a polymer such as ePTFE or a fabric like Dacron attached to the frame, thereby showing the prosthetic cardiac valve 1000.
  • the atrial skirt may be entirely covered by a material, the covering is only disposed between adjacent stmts 1012 in adjacent cells in the flanged portion of the atrial skirt.
  • the area 1014 between adjacent stmts within the same cell remain uncovered. This allows blood flow to remain substantially uninterrupted while the prosthetic valve is being implanted.
  • Suture 1010 may be used to attach the cover to the frame. In this view, only the posterior tab 1006 is visible on the posterior portion of the prosthetic valve along with ventricular skirt 1008 and atrial skirt 1004.
  • FIGs. 11 A-l 1D illustrate an example of a delivery system that may be used to deliver any of the prosthetic cardiac valves disclosed in this specification. While the delivery system is designed to preferably deliver the prosthetic cardiac valve transapically, one of skill in the art will appreciate that it may also be modified so that the prosthetic valve may be delivered via a catheter transluminally, such using a transseptal route. One of skill in the art will appreciate that using a transseptal route may require the relative motion of the various shafts to be modified in order to accommodate the position of the delivery system relative to the mitral valve.
  • Fig. 11 A illustrates a perspective view of delivery system 1100.
  • the delivery system 1100 includes a handle 1112 near a proximal end of the delivery system and a distal tissue penetrating tip 1110.
  • Four elongate shafts are included in the delivery system and include an outer sheath catheter shaft 1102, a bell catheter shaft 1104 which is slidably disposed in the outer sheath catheter shaft 1102, a hub catheter shaft 1106 which remains stationary relative to the other shafts, but the bell catheter shaft slides relative to the hub shaft, and finally an inner guidewire catheter shaft 1108 which is also fixed relative to the other shafts and has a lumen sized to receive a guidewire which passes therethrough and exits the distal tissue penetrating tip.
  • An actuator mechanism 1114 is used to control movement of the various shafts as will be explained in greater detail below, and flush lines 1116, 1118 with Luer connectors are used to flush the annular regions between adjacent shafts.
  • Flush line 1118 is used to flush the annular space between the outer sheath catheter shaft 1102 and the bell catheter shaft 1104.
  • Flush line 1116 is used to flush the annular space between the bell catheter 1104 and the hub catheter 1106.
  • the inner guidewire catheter shaft 1108 is stationary relative to the hub catheter 1106 therefore the annular space may be sealed with an O-ring or other material.
  • Luer connector 1122 allows flushing of the guidewire lumen and a hemostatic valve such as a Tuohy-Borst may be coupled to the Luer connector to allow a guidewire to be advanced through the guidewire catheter shaft while maintaining hemostasis. Screws 1120 keep the handle housing coupled together.
  • Fig. 11B illustrates a side view of the delivery system 1100.
  • Fig. 11C is a partial exploded view of the delivery system 1100 and more clearly illustrates the components in the handle 1112 and how they interact.
  • the handle 1112 includes a housing having two halves 11 l2a, 1112b which hold all the components.
  • the handle is preferably held together with screws 1120 and nuts 1 l20b, although it may also be sealed using other techniques such as a press fit, snap fit, adhesive bonding, ultrasonic welding, etc.
  • Rotation of actuator wheel 1114 is translated into linear motion of threaded insert 1124.
  • the outer sheath catheter shaft 1102 is coupled to the threaded insert 1124, therefore rotation of actuator wheel 1114 in one direction will advance the sheath catheter shaft 1102, and rotation in the opposite direction will retract the sheath catheter shaft 1102.
  • actuator wheel 1114 retracts threaded insert 1124 enough to bump into pins 1126 which are coupled to insert 1128, thereby also moving insert 1128.
  • the bell catheter shaft 1106 is coupled to insert 1128, therefore further rotation of the actuator wheel 1114 will move the outer shaft 1102 and also move the bell catheter shaft 1106.
  • Rotation of the actuator wheel in the opposite direction advances the sheath and threaded insert 1124 disengages from pins 1126.
  • Spring 1130 returns insert 1128 to its unbiased position, thereby returning the bell catheter shaft to its unbiased position.
  • Any of the prosthetic cardiac valves disclosed herein may be carried by delivery system 1100.
  • the atrial skirt, annular skirt, anterior tabs, posterior tab and ventricular skirt are loaded over the bell catheter shaft and disposed under the outer sheath catheter shaft 1102.
  • the ventricular skirt is loaded proximally so that it is closest to the handle 1112 and the atrial skirt is loaded most distally so it is closest to the tip 1110. Therefore, retraction of outer sheath catheter shaft 1102 plays a significant part in controlling deployment of the prosthetic cardiac valve.
  • the atrial skirt therefore expands first when the outer sheath catheter is retracted.
  • the prosthetic valve commissures may be coupled with a hub 1 l06a on the distal portion of hub catheter 1106 and then the bell catheter shaft is disposed thereover, thereby releasably engaging the commissures with the delivery catheter. Once other portions of the prosthetic cardiac valve have expanded, the commissures may be released.
  • Fig. 11D highlights the distal portion of the delivery system 1100.
  • Outer sheath catheter shaft 1102 advances and retracts relative to bell catheter shaft 1104 which is slidably disposed in the outer sheath catheter shaft 1102.
  • Flub catheter shaft 1106 is shown slidably disposed in bell catheter shaft 1104 and with bell catheter shaft 1104 retracted so as to expose the hub 1 l06a having slots 1 l06b that hold the prosthetic valve commissures.
  • Inner guidewire catheter shaft 1108 is the innermost shaft and has a tapered conical section 1130 which provides a smooth transition for the prosthetic valve and prevents unwanted bending or buckling of the prosthetic cardiac valve frame.
  • Tissue penetrating tip 1110 is adapted to penetrate tissue, especially in a cardiac transapical procedure.
  • a number of methods may be used to deliver a prosthetic cardiac valve to the heart
  • methods of delivering a prosthetic mitral valve may include a transluminal delivery route which may also be a transseptal technique which crosses the septum between the right and left sides of the heart, or in other examples, a transapical route may be used such as illustrated in Figs. 12A-12L.
  • the delivery device previously described above may be used to deliver any of the prosthetic valves described herein, or other delivery devices and other prosthetic valves may also be used, such as those disclosed in US Patent Application No. 13/096,572, previously incorporated herein by reference.
  • the prosthetic cardiac valve of Fig. 6 is used so that the anterior tabs deploy first, followed by the posterior tab, and then the ventricular skirt.
  • Fig. 12A illustrates the basic anatomy of the left side of a patient’s heart including the left atrium LA and left ventricle LV.
  • Pulmonary veins PV return blood from the lungs to the left atrium and the blood is then pumped from the left atrium into the left ventricle across the mitral valve MV.
  • the mitral valve includes an anterior leaflet AL on an anterior side A of the valve and a posterior leaflet PL on a posterior side P of the valve.
  • the leaflets are attached to chordae tendineae CT which are subsequently secured to the heart walls with papillary muscles PM.
  • the blood is then pumped out of the left ventricle into the aorta Ao with the aortic valve AV preventing regurgitation.
  • Fig. 12B illustrates transapical delivery of a delivery system 1202 through the apex of the heart into the left atrium LA via the left ventricle LV.
  • the delivery system 1202 may be advanced over a guidewire GW into the left atrium, and a tissue penetrating tip 1204 helps the delivery system pass through the apex of the heart by dilating the tissue and showing a larger channel for the remainder of the delivery system to pass through.
  • the delivery catheter carries prosthetic cardiac valve 1208. Once the distal portion of the delivery system has been advanced into the left atrium, the outer sheath 1206 may be retracted proximally (e.g. toward the operator) thereby removing the constraint from the atrial portion of the prosthetic valve 1208.
  • the atrial skirt 1210 may self-expand radially outward.
  • the atrial skirt may have a cylindrical shape or it may be D-shaped as discussed above with a flat anterior portion and a cylindrical posterior portion so as to avoid interfering with the aortic valve and other aspects of the left ventricular outflow tract.
  • the prosthesis may be oriented and properly positioned by rotating the prosthesis and visualizing the alignment element previously described.
  • the prosthetic cardiac valve may be advanced upstream or downstream to properly position the atrial skirt.
  • the atrial skirt disposes a flange that rests against a superior surface of the mitral valve and this anchors the prosthetic valve and prevents it from unwanted movement downstream into the left ventricle.
  • the annular region of the prosthetic cardiac valve self-expands within the valve annulus.
  • the annular region also preferably has the D-shaped geometry, although it may also be cylindrical or have other geometries to match the native anatomy.
  • retraction of sheath 1206 eventually allows both the anterior 1212 and posterior 1214 tabs to partially self-expand outward preferably without engaging the anterior or posterior leaflets or the chordae tendineae.
  • Fig. 12G further retraction of the outer sheath 1206 then releases the constraints from the posterior tab 1214 allowing it to complete its self-expansion, thereby capturing the posterior leaflet PL between an inner surface of the posterior tab 1214 and an outer surface of the ventricular skirt 1218.
  • Fig. 12H the sheath is retracted further releasing the ventricular skirt 1220 and allowing the ventricular skirt 1220 to radially expand outward, further capturing the anterior and posterior leaflets between the outer surface of the ventricular skirt and their respective anterior or posterior tabs.
  • Expansion of the ventricular skirt also pushes the anterior and posterior leaflets outward, thereby ensuring that the native leaflets do not interfere with any portion of the prosthetic valve or the prosthetic valve leaflets.
  • the prosthetic valve is now anchored in position above the mitral valve, along the annulus, to the valve leaflets, and below the mitral valve, thereby securing it in position.
  • Figs. 12K and 12L highlight engagement of the anterior and posterior tabs with the respective anterior and posterior leaflets.
  • anterior tabs 1212 after anterior tabs 1212 have been fully expanded, they capture the anterior leaflet AL and adjacent chordae tendineae between an inside surface of the anterior tab and an outer surface of the ventricular skirt 1220.
  • the anterior tabs 1212 advance under (toward the ventricle) and behind the anterior leaflet AL and adjacent chordae tendineae, before the ventricular skirt 1220 expands and pushes out to capture the anterior leaflet AL and adjacent chordae tendinae between the ventricular skirt 1220 and the anterior tabs 1212.
  • the tips 1228 of the anterior tabs 1212 are engaged with the fibrous trigones FT of the anterior side of the mitral valve.
  • the fibrous trigones are fibrous regions of the valve thus the anterior tabs further anchor the prosthetic valve into the native mitral valve anatomy.
  • One anterior tab anchors into the left fibrous trigone, and the other anterior tabs anchors into the right fibrous trigone.
  • the trigones are on opposite sides of the anterior side of the leaflet.
  • Fig. 12L illustrates engagement of the posterior tab 1214 with the posterior leaflet PL which is similarly captured between an inner surface of the posterior tab and an outer surface of the ventricular skirt 1220. Additionally, adjacent chordae tendineae are also captured between the posterior tab and ventricular skirt.
  • the posterior tab 1214 advance under (toward the ventricle) and behind the posterior leaflet PL and adjacent chordae tendineae, before the ventricular skirt 1220 expands and pushes out to capture the posterior leaflet PL and adjacent chordae tendinae between the ventricular skirt 1220 and the posterior tab 1214.
  • FIGs. 13A-13L illustrate another example of a delivery method.
  • This example is similar to that previously described, with the major difference being the order in which the prosthetic cardiac valve self-expands into engagement with the mitral valve.
  • Any delivery device or any prosthetic cardiac valve disclosed herein may be used, however in the aforementioned examples, Fig. 7 is used. Varying the order may allow better positioning of the implant, easier capturing of the valve leaflets, and better anchoring of the implant.
  • This method also preferably uses a transapical route, although transseptal may also be used.
  • Fig. 13A illustrates the basic anatomy of the left side of a patient’s heart including the left atrium LA and left ventricle LV.
  • Pulmonary veins PV return blood from the lungs to the left atrium and the blood is then pumped from the left atrium into the left ventricle across the mitral valve MV.
  • the mitral valve includes an anterior leaflet AL on an anterior side A of the valve and a posterior leaflet PL on a posterior side P of the valve.
  • the leaflets are attached to chordae tendineae CT which are subsequently secured to the heart walls with papillary muscles PM.
  • the blood is then pumped out of the left ventricle into the aorta AO with the aortic valve AV preventing regurgitation.
  • Fig. 13B illustrates transapical delivery of a delivery system 1302 through the apex of the heart into the left atrium LA via the left ventricle LV.
  • the delivery system 1302 may be advanced over a guidewire GW into the left atrium, and a tissue penetrating tip 1304 helps the delivery system pass through the apex of the heart by dilating the tissue and showing a larger channel for the remainder of the delivery system to pass through.
  • the delivery catheter carries prosthetic cardiac valve 1308. Once the distal portion of the delivery system has been advanced into the left atrium, the outer sheath 1306 may be retracted proximally (e.g. toward the operator) thereby removing the constraint from the atrial portion of the prosthetic valve 1308.
  • the atrial skirt 1310 may self-expand radially outward.
  • the atrial skirt may have a cylindrical shape or it may be D-shaped as discussed above with a flat anterior portion and a cylindrical posterior portion so as to avoid interfering with the aortic valve and other aspects of the left ventricular outflow tract.
  • the prosthesis may be oriented and properly positioned by rotating the prosthesis and visualizing the alignment element previously described.
  • the prosthetic cardiac valve may be advanced upstream or downstream to properly position the atrial skirt.
  • the atrial skirt has a flange that rests against a superior surface of the mitral valve and this anchors the prosthetic valve and prevents it from unwanted movement downstream into the left ventricle.
  • the annular region of the prosthetic cardiac valve self-expands within the valve annulus.
  • the annular region also preferably has the D-shaped geometry, although it may also be cylindrical or have other geometries to match the native anatomy.
  • retraction of sheath 1306 eventually allows both the anterior 1312 and posterior 1314 tabs to partially self-expand outward preferably without engaging the anterior or posterior leaflets or the chordae tendineae.
  • Fig. 13G further retraction of the outer sheath 1306 then releases the constraint from the ventricular skirt 1320 allowing the ventricular skirt to radially expand. This then further captures the anterior leaflets AL between the anterior tab 1312 and the ventricular skirt 1316. Expansion of the ventricular skirt also pushes the anterior and posterior leaflets outward, thereby ensuring that the native leaflets do not interfere with any portion of the prosthetic valve or the prosthetic valve leaflets. Further retraction of sheath 1306 as illustrated in Fig. 13H releases the constraint from the posterior tab 1314 allowing it to complete its self-expansion, thereby capturing the posterior leaflet PL between an inner surface of the posterior tab 1314 and an outer surface of the ventricular skirt 1318. The prosthetic valve is now anchored in position above the mitral valve, along the annulus, to the valve leaflets, and below the mitral valve, thereby securing it in position.
  • Figs. 13K and 13L highlight engagement of the anterior and posterior tabs with the respective anterior and posterior leaflet.
  • anterior tabs 1312 after anterior tabs 1312 have been fully expanded, they capture the anterior leaflet AL and adjacent chordae tendineae between an inside surface of the anterior tab and an outer surface of the ventricular skirt 1320.
  • the tips 1328 of the anterior tabs 1312 are engaged with the fibrous trigones FT of the anterior side of the mitral valve (similarly to anterior tabs 1212 described above).
  • the fibrous trigones are fibrous regions of the valve thus the anterior tabs further anchor the prosthetic valve into the native mitral valve anatomy.
  • FIG. 13L illustrates engagement of the posterior tab 1314 with the posterior leaflet PL which is captured between an inner surface of the posterior tab and an outer surface of the ventricular skirt 1320 (similarly to posterior tab 1214 described above). Additionally, adjacent chordae tendineae are also captured between the posterior tab and ventricular skirt.
  • Fig. 14A-14D illustrate another example that is preferably used with the anterior trigonal tabs to help reduce trauma. It may also be used with the posterior tab if desired.
  • Fig. 14A illustrates an anterior trigonal tab 1402 having a tip
  • Fig. 14B illustrates a polymer tab 1406 that may be attached to the trigonal tab 1402.
  • the tab may be examples from other materials such as fabric, metals, or other materials known in the art.
  • the polymer tab may be laser cut from a sheet of polymer and includes a long axial portion 1408 and an enlarged head region 1410.
  • a plurality of suture holes 1412 may be pre-cut into the polymer tab 1406 and the holes are sized to receive suture material.
  • Precut holes on the polymer tab may be aligned with pre-cut holes on the trigonal tab and then the polymer tab may be secured to the trigonal tab with sutures, adhesives, or other coupling techniques known in the art.
  • a fabric cover 1414 having two symmetric halves separated by a hinged area 1416 is then wrapped around the polymer tab and attached to the polymer tab by sutures, thereby showing a shroud around the trigonal tab.
  • the fabric may be Dacron, ePTFE, or any other biocompatible material known in the art.
  • the cover increases the surface area of contact between the trigonal tabs and the tissue thereby reducing potential trauma and likelihood of piercing the heart wall. Additionally, the material may allow tissue ingrowth which further helps to anchor the prosthesis. Materials and dimensions are also selected in order to maintain the low profile of the device during delivery in the collapsed configuration.
  • the deployment of the tabs may be controlled by controlling strut length and/or axial position of the anterior and/or posterior tabs.
  • the axial position of the atrial end of the tabs may be varied to vary when the tabs begin deployment as the constraining sheath is retracted, and the axial position of the ventricular end of the tabs may be varied to vary when the tabs are fully deployed as the constraining sheath is retracted.
  • Particular sequences of deployment may be more optimal to certain anatomies and may allow the prosthetic valve to be more accurately delivered and more securely anchored into position.
  • either the anterior tab(s) or the posterior tab(s) may be more easily visualized than the other in at least some cases, and the more easily visualized tab may be configured to deploy first as a guide to orient the frame during implantation.
  • the posterior tab is easier to visualize using ultrasound and/or fluoroscopy.
  • the sequence of tab deployment may be customized to the individual patient and their anatomy in some cases and the customization may be based on pre-screen imaging data for the individual patient.
  • the tabs that are projected to be more easily visualized, such as by using ultrasound and/or fluoroscopy may be configured to deploy first.
  • the initially deployed tabs can allow for intermediate movement of the imaging source, e.g., the C-arm controlling the ultrasound or X-ray device for fluoroscopy, so as to provide verification of the initial tab placements.
  • the prosthetic valve may be repositioned and/or reoriented with the initial tab(s) partially and/or fully deployed (and the remaining tab(s) yet to be partially and/or fully deployed) based on the imaging or visualization.
  • the length and/or curvature of one or more of the tabs may be customized for the individual patient and their anatomy.
  • the length and/or curvature of the one or more tabs may be customized to provide an optimum fit for the individual patient’s anatomy, such as the deployment area behind the valve leaflet(s) and/or the chordae tendinae.
  • FIGS. 15A-15E schematically illustrate the deployment of a prosthetic cardiac valve l500a whereby its first anterior tab Al and its second anterior tab A2 are concurrently deployed.
  • FIG. 15A shows a constraining sheath 1550 fully constraining the prosthetic cardiac valve l500a.
  • the prosthetic cardiac valve l500a may be deployed as the constraining sheath 1550 is retracted from the atrial (ATR) side of the prosthetic cardiac valve l500a to the ventricular (VEN) side. As shown in FIG.
  • the retraction of the constraining sheath 1550 may first allow the atrial skirt 1506 of the prosthetic cardiac valve 1500 to begin to self-expand radially outward.
  • the constraining sheath 1550 may be retracted further to concurrently release the first anterior tab Al and the second anterior tab A2 from constraint, exposing the tabs.
  • further retraction of the constraining sheath l500a allows the first anterior tab Al and the second anterior tab A2 to partially spring radially outward to be in orientations that are transverse to the longitudinal axes of the constraining sheath 1550 and prosthetic cardiac valve l500a as described above.
  • the first and second anterior tabs Al, A2 may have the same length and/or may be positioned on the prosthetic cardiac valve so that their atrial ends are positioned in the same axial position; hence, the retraction of the constraining sheath 1550 may expose the anterior tabs Al, A2 and/or allow the anterior tabs Al, A2 to partially deploy concurrently. As shown in FIG. 15E, the constraining sheath 1550 may be fully retracted to fully release the prosthetic cardiac valve l500a, allowing the anterior tabs Al, A2 to fully deploy to capture the adjacent chordae tendineae and also to allow the ventricular skirt 1516 to self-expand radially outward.
  • the posterior tab PTB of the prosthetic cardiac valve 1500 while not shown in FIGS. 15A-15E, may be configured to deploy before, concurrently with, or after the anterior tabs Al, A2.
  • FIGS. 15F-15L schematically illustrate the deployment of a prosthetic cardiac valve l500b whereby its first anterior tab Al and its second anterior tab A2 are sequentially deployed.
  • FIG. 15F shows a
  • the prosthetic cardiac valve l500b may be deployed as the constraining sheath 1550 is retracted from the atrial (ATR) side of the prosthetic cardiac valve 1500 to the ventricular (VEN) side. As shown in FIG. 15G, the retraction of the constraining sheath 1550 may first allow the atrial skirt 1506 of the prosthetic cardiac valve l500b to begin to self-expand radially outward. As shown in FIG.
  • the constraining sheath 1550 may be retracted further to concurrently release the first anterior tab Al and the second anterior tab A2 from constraint, exposing the tabs.
  • FIG. 151 further retraction of the constraining sheath 1550 allows the first anterior tab Al to partially spring radially outward to be in orientations that are transverse to the longitudinal axes of the constraining sheath 1550 and prosthetic cardiac valve l500b as described above, while the second anterior tab A2 remains in an undeployed configuration.
  • FIG. 15J even further retraction of the constraining sheath 1550 fully frees the first anterior tab Al from constraint, allowing the first anterior tab Al to fully deploy to capture adjacent chordae tendineae.
  • FIG. 151 further retraction of the constraining sheath 1550 allows the first anterior tab Al to partially spring radially outward to be in orientations that are transverse to the longitudinal axes of the constraining sheath 1550 and prosthetic cardiac valve l500b as described above, while the second anterior tab A
  • the posterior tab PTB of the prosthetic cardiac valve l500b may be configured to deploy before one or both of the anterior tabs Al, A2, concurrently with one of the anterior tabs Al, A2, or after one or both of the anterior tabs Al, A2.
  • FIGS. 15A-15E and FIGS. 15F-15L show particular sequences of fully deploying the first and second anterior tabs Al, A2 and the posterior tab PTB, the first and second tabs Al, A2 and the posterior tab PTB may be configured to fully deploy in any order.
  • FIG. 16A shows the prosthetic cardiac valve 1500 held within the constraining sheath 1550 while FIG. 16B schematically illustrates a cross- section of the prosthetic cardiac calve 1500 taken along line B-B of FIG. 16B and showing the relative positions of the first and second tabs Al, A2 and the posterior tab PTB.
  • FIGS. 17A-17M the first and second anterior tabs Al, A2 (particularly their ventricular ends), the posterior tab PTB (particularly its ventricular end), and the edges VI, V2, and V3 of the ventricular skirt are shown in a rolled out configuration relative to a retracting constraining sheath 1550 to show various orders of full deployment of the first and second anterior tabs Al, A2 and the posterior tab PTB.
  • the lengths of the tabs and/or the axial positions of the free ends 1701, 1702, 1703 of the tabs may be varied such that two or more of the two anterior tabs Al, A2 and the posterior tab PTB are fully deployed concurrently.
  • a distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • the first and second anterior tabs Al, A2 and the posterior tab PTB may all have the same length and/or have their free ends 1701, 1702, 1703 in the same axial positions. Therefore, the three tabs Al, A2, PTB are be fully deployed concurrently with one another as the distal edge 1650 of the constraining sheath 1550 retracts proximally in the direction of arrow Al parallel to the longitudinal axis of the valve.
  • the edges VI, V2, V3 of the ventricular skirt are closer to the annular region than the free ends 1701, 1702 1703 of the three tabs Al, A2, PTB such that, as the sheath 1550 is retracted, the ventricular skirt is configured to deploy before the tabs Al, A2, PTB finish expanding.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • FIG. 17B the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • the first and second anterior tabs Al, A2 may have the same length as each other, and the posterior tab PTB may have a greater length than the first and second anterior tabs Al, A2, and/or the free end 1703 of the posterior tab PTB may be further from the annular region than the free ends 1701, 1702 of the first and second anterior tabs Al, A2. Therefore, as the distal edge 1650 of the constraining sheath 1550 retracts proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve, the first and second anterior tabs Al, A2 are concurrently fully deployed before the posterior tab PTB is fully deployed.
  • edges VI, V2, V3 of the ventricular skirt are closer to the annular region than the free ends 1701, 1702, 1703 of the three tabs Al, A2, PTB such that, as the sheath 1550 is retracted, the ventricular skirt is configured to deploy before the tabs Al, A2, PTB finish expanding.
  • the 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • the first and second anterior tabs Al, A2 may have the same length as each other, and the posterior tab PTB may have a shorter length than the first and second anterior tabs Al, A2, and/or the free end 1703 of the posterior tab PTB may be closer to the annular region than the free ends 1701, 1702 of the first and second anterior tabs Al, A2.
  • the first and second anterior tabs Al, A2 are concurrently fully deployed after the posterior tab PTB is fully deployed.
  • the edges VI, V2, V3 of the ventricular skirt are closer to the annular region than the free ends 1701, 1702, 1703 of the three tabs Al, A2,
  • the ventricular skirt is configured to deploy before the tabs Al, A2, PTB finish expanding.
  • the lengths of the tabs and/or the axial positions of the ventricular ends of the tabs may be varied such that one of the two anterior tabs Al, A2 may have the same length as the posterior tab PTB and/or their free ends may be in the same axial position. In this case, one of the two anterior tabs Al, A2 is fully deployed concurrently with the posterior tab PTB.
  • the lengths of the tabs and/or the axial positions of the free ends of the tabs may be varied such that the second of the anterior tabs Al , A2 may be allowed to fully deploy before or after the concurrent full deployment of the first of the anterior tabs Al, A2 and the posterior tab PTB.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • the first anterior tab Al may have the same length as the posterior tab PTB and/or their free ends 1701, 1703 may be in the same axial position.
  • the second anterior tab A2 may have a greater length than the first anterior tab Al and the posterior tab PTB and/o its free end 1702 may be further from the annular region than the free ends 1701, 1703 of the first anterior tab Al and the posterior tab PTB.
  • edges VI, V2, V3 of the ventricular skirt are closer to the annular region than the free ends 1701, 1702, 1703 of the three tabs Al, A2, PTB such that, as the sheath 1550 is retracted, the ventricular skirt is configured to deploy before the tabs Al, A2, PTB finish expanding.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • the second anterior tab A2 and the posterior tab PTB may have the same length as each other, as the first anterior tab Al may have a longer length than the second anterior tab A2 and the posterior tab PTB, and/or the free ends 1702, 1703 of the second anterior tab A2 and the posterior tab PTB may be closer to the annular region than the free end 1701 of the first anterior tab Al. Therefore, as the distal edge 1650 of the constraining sheath retracts proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve, the second anterior tab A2 fully deploys concurrently with the posterior tab PTB, and the first anterior tab Al fully deploys after.
  • edges VI, V2, V3 of the ventricular skirt are closer to the annular region than the free ends 1701, 1702, 1703 of the three tabs Al, A2, PTB such that, as the sheath 1550 is retracted, the ventricular skirt is configured to deploy before the tabs Al, A2, PTB finish expanding.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • FIG. 17E the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • the second anterior tab A2 and the posterior tab PTB may have the same length as each other and the first anterior tab Al may have a shorter length than the second anterior tab A2 and the posterior tab PTB, and/or the free ends 1702, 1703 of the second anterior tab A2 and the posterior tab PTB may be further from the annular region than the free end 1701 of the first anterior tab Al.
  • the first anterior tab Al fully deploy first, followed by the second anterior tab A2 and the posterior tab PTB concurrently.
  • the edges VI, V2, V3 of the ventricular skirt are closer to the annular region than the free ends 1701, 1702, 1703 of the three tabs Al, A2, PTB such that, as the sheath 1550 is retracted, the ventricular skirt is configured to deploy before the tabs Al, A2, PTB finish expanding.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • the first anterior tab Al and the posterior tab PTB may have the same length as each other and the second anterior tab Al may have a shorter length than the first anterior tab Al and the posterior tab PTB, and/or the free ends 1701, 1703 of the first anterior tab Al and the posterior tab PTB may be further from the annular region than the free end 1702 of the second anterior tab A2.
  • the second anterior tab A2 fully deploy first, followed by the first anterior tab Al and the posterior tab PTB concurrently.
  • the edges VI, V2, V3 of the ventricular skirt are closer to the annular region than the free ends 1701, 1702, 1703 of the three tabs Al, A2, PTB such that, as the sheath 1550 is retracted, the ventricular skirt is configured to deploy before the tabs Al, A2, PTB finish expanding.
  • the lengths of the tabs and/or the axial positions of the ventricular ends of the tabs may be varied such that one of the two anterior tabs Al, A2 is fully deployed before the posterior tab PTB.
  • the lengths of the tabs and/or the axial positions of the ventricular ends of the tabs may be varied such that the second of the anterior tabs Al, A2 may be allowed to fully deploy before or after the full deployment of the posterior tab PTB.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • FIG. 17G the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • the posterior tab PTB may be longer than the second anterior tab A2 which may be longer than the first anterior tab Al, and/or the free end 1703 of the posterior tab PTB may be further from the annular region than the free end 1702 of the second anterior tab A2 which may be further from the annular region than the free end 1701 of the first anterior tab Al.
  • the first anterior tab Al fully deploys first with the edges of VI, V2, V3 of the ventricular skirt, followed by the second anterior tab A2, and then followed by the posterior tab PTB.
  • edges VI, V2, V3 of the ventricular skirt are closer to the annular region than the free ends 1702, 1703 of the second anterior tab, A2, and the posterior tab PTB such that, as the sheath 1550 is retracted, the ventricular skirt is configured to deploy concurrently with Al and before the tabs A2, PTB finish expanding.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • FIG. 17H the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • the posterior tab PTB may be longer than the first anterior tab Al which may be longer than the second anterior tab A2, and/or the free end 1703 of the posterior tab PTB may be further from the annular region than the free end 1701 of the first anterior tab Al which may be further from the annular region than the free end 1702 of the second anterior tab A2.
  • the second anterior tab A2 fully deploy first with the edges of VI, V2, V3 of the ventricular skirt, followed by the first anterior tab Al , and then followed by the posterior tab PTB.
  • edges VI, V2, V3 of the ventricular skirt are closer to the annular region than the free ends 1701, 1703 of the first anterior tab Al, and the posterior tab PTB such that, as the sheath 1550 is retracted, the ventricular skirt is configured to deploy concurrently with A2 and before the tabs Al, PTB finish expanding.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • the second anterior tab A2 may be longer than the posterior tab PTB which may be longer than the first anterior tab Al, and/or the free end 1702 of the second anterior tab A2 may be further from the annular region than the free end 1703 of the posterior tab PTB which may be further from the annular region than the free end 1701 of the first anterior tab.
  • the first anterior tab Al fully deploys first with the edges of VI, V2, V3 of the ventricular skirt, followed by the posterior tab PTB, and the second anterior tab A2.
  • the edges VI, V2, V3 of the ventricular skirt are closer to the annular region than the free ends 1702,
  • the ventricular skirt is configured to deploy concurrently with Al and before the tabs A2 and PTB finish expanding.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • the first anterior tab Al may be longer than the posterior tab PTB which may be longer than the second anterior tab A2, and/or the free end 1701 of the first anterior tab Al may be further from the annular region than the free end 1703 of the posterior tab PTB which may be further from the annular region than the free end 1702 of the second anterior tab A2.
  • the second anterior tab A2 fully deploys first with the edges of VI, V2, V3 of the ventricular skirt, followed by the posterior tab PTB, and then followed by the first anterior tab Al.
  • the edges VI, V2, V3 of the ventricular skirt are closer to the annular region than the free ends 1701, 1703 of the first anterior tab Al, and posterior tab PTB such that, as the sheath 1550 is retracted, the ventricular skirt is configured to deploy concurrently with A2 and before the tabs Al, PTB finish expanding.
  • the lengths of the tabs and/or the axial positions of the ventricular ends of the tabs may be varied such that the posterior tab PTB is fully deployed first.
  • the lengths of the tabs and/or the axial positions of the ventricular ends of the tabs may be varied such that the anterior tabs Al , A2 fully deploy either sequentially or concurrently after the full deployment of the posterior tab PTB.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • FIG. 17K the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • the second anterior tab A2 may be longer than the first anterior tab Al which may be longer than the posterior tab PTB, and/or the free end 1702 of the second anterior tab A2 may be further from the annular region than the free end
  • the posterior tab PTB fully deploys first with the edges of VI, V2, V3 of the ventricular skirt, followed by the first anterior tab Al and then the second anterior tab A2.
  • the edges V 1 , V2, V3 of the ventricular skirt are closer to the annular region than the free ends 1701, 1702, of the first and second anterior tabs Al, A2 such that, as the sheath 1550 is retracted, the ventricular skirt is configured to deploy concurrently with PTB and before the tabs Al and A2 finish expanding.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • FIG. 17L the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • the first anterior tab Al may be longer than the second anterior tab A2 which may be longer than the posterior tab PTB, and/or the free end 1701 of the first anterior tab Al may be further from the annular region than the free end
  • the posterior tab PTB fully deploys first with the edges of VI, V2, V3 of the ventricular skirt, followed by the second anterior tab A2 and then the first anterior tab Al .
  • the edges V 1 , V2, V3 of the ventricular skirt are closer to the annular region than the free ends 1701, 1702 of the first and second anterior tabs Al, A2 such that, as the sheath 1550 is retracted, the ventricular skirt is configured to deploy concurrently with PTB and before the tabs Al and A2 finish expanding.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR1 parallel to the longitudinal axis of the valve during tab deployment.
  • the first anterior tab Al and the second anterior tab A2 may have the same length and both may be longer than the posterior tab PTB, and/or the free end 1701 of the first anterior tab Al and the free end 1702 of the second anterior tab A2 may be the same distance from the annular region and both may be further from the annular region than the free end 1703 of the posterior tab.
  • the posterior tab PTB fully deploys first with the edges of VI , V2, V3 of the ventricular skirt, followed by the first anterior tab Al and the second anterior tab A2 concurrently.
  • the edges VI, V2, V3 of the ventricular skirt are closer to the annular region than the free ends 1701, 1702 of the first and second anterior tabs Al, A2 such that, as the sheath 1550 is retracted, the ventricular skirt is configured to deploy concurrently with PTB and before the tabs Al and A2 finish expanding.
  • FIGS. 17A-17M show the ventricular skirt (and its edges
  • the ventricular skirt may be configured to deploy in any order, for example, before any combination of the tabs, after any combination of the tabs, and/or concurrently with any of the tabs.
  • One or more of the sides VI , V2, and V3 may deploy before the remaining sides.
  • the anterior and posterior tabs may partially deploy upon retraction of the constraining sheath 1550, such as to deploy to an orientation transverse to the longitudinal axes of the prosthetic cardiac valve and the constraining sheath.
  • This partially deployed position of the tabs may position the tabs relative to one or more of the anterior leaflet AL, the posterior leaflet PL, or the adjacent chordae tendinae for subsequent engagement and capture by the tabs upon full deployment.
  • One or more of the partially deployed anterior or posterior tabs may be visualized to confirm proper positioning and/or orientation of the prosthetic cardiac valve and its tabs.
  • the prosthetic valve may be repositioned and/or reoriented with the initial tab(s) deployed (and the remaining tab(s) yet to be deployed) based on the imaging or visualization.
  • the prosthetic cardiac valve may be repositioned and/or reoriented.
  • the anterior and posterior tabs may partially deploy in any order and in any combination with any order of the full deployment of the tabs as described above with respect to FIGS. 17A-17B. For the ease of illustration in the following described FIGS.
  • the first and second anterior tabs Al, A2 are shown in a rolled out configuration relative to a retracting constraining sheath 1550 to show various orders of partial deployment of the first and second anterior tabs Al, A2 and the posterior tab PTB.
  • the lengths of the tabs and/or the axial positions of the atrial ends of the tabs may be varied such that two or more of the two anterior tabs Al, A2 and the posterior tab PTB are partially deployed concurrently.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • FIG. 18A the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • the first and second anterior tabs Al, A2 and the posterior tab PTB may have the same lengths, and/or their atrial ends 1801, 1802, 1803 may be in the same axial position away from the annular region.
  • the first and second anterior tabs Al, A2 and the posterior tab PTB will partially deploy concurrently with one another as the constraining sheath 1550 is retracted.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • FIG. 18B the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • the first and second anterior tabs Al, A2 may have the same lengths and both may be longer than the posterior tab PTB, and/or the atrial ends 1801, 1802 of both the first and second anterior tabs Al, A2 may be in the same axial position away from the annular region and both may be further from the annular region than the atrial end 1803 of the posterior tab PTB.
  • the first and second anterior tabs Al, A2 will concurrently partially deploy before the posterior tab PTB is partially deployed as the constraining sheath 1550 is retracted.
  • the 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • the first and second anterior tabs Al, A2 may have the same lengths and both may be shorter than the posterior tab PTB, and/or the atrial ends 1801, 1802 of both the first and second anterior tabs Al, A2 may be in the same axial position away from the annular region and both may be closer to the annular region than the atrial end 1803 of the posterior tab PTB.
  • the first and second anterior tabs Al, A2 will concurrently partially deploy after the posterior tab PTB is partially deployed as the constraining sheath 1550 is retracted.
  • the lengths of the tabs and/or the axial positions of the atrial ends of the tabs may be varied such that one of the two anterior tabs Al, A2 is partially deployed concurrently with the posterior tab PTB.
  • the lengths of the tabs and/or the axial positions of the atrial ends of the tabs may be varied such that the second of the anterior tabs Al , A2 may be allowed to partially deploy before or after the concurrent partial deployment of the first of the anterior tabs Al, A2 and the posterior tab PTB.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • FIG. 18C the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • the first anterior tab Al and the posterior tab PTB may have the same lengths and both may be longer than the second anterior tab A2, and/or the atrial ends 1801, 1803 of both the first anterior tab Al and posterior tab PTB may be in the same axial position away from the annular region and both may be further from the annular region than the atrial end 1802 of the second anterior tab A2.
  • the first anterior tab Al will partially deploy concurrently with the posterior tab PTB and the second anterior tab A2 will partially deploys after as the constraining sheath 1550 is retracted.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • FIG. 18D the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • the second anterior tab A2 may be the same length as the posterior tab PTB, both of which may be longer than the first anterior tab Al, and/or the atrial end 1802 of the second anterior tab A2 may be in an axial position relative to the annular region that is the same as the axial position of the atrial end 1803 of the posterior tab PTB, both of which may be in an axial position further from the annular region than the atrial end 1801 of the first anterior tab Al.
  • the second anterior tab A2 will partially deploy concurrently with the posterior tab PTB and the first anterior tab Al will partially deploy after as the constraining sheath 1550 is retracted.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • FIG. 18E the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • the second anterior tab A2 and the posterior tab PTB may have the same length and both may be shorter than the first anterior tab Al, and/or the atrial ends 1802, 1803 of the second anterior tab A2 and the posterior tab PTB may be in the same axial positions away from the annular region which are closer to the annular region than the atrial end 1801 of the first anterior tab Al.
  • the first anterior tab Al will partially deploy first, followed by the second anterior tab A2 and the posterior tab PTB concurrently, as the constraining sheath 1550 is retracted.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • the first anterior tab Al and the posterior tab PTB may have the same length and both may be shorter than the second anterior tab A2, and/or the atrial ends 1801, 1803 of the first anterior tab Al and the posterior tab PTB may be in the same axial positions away from the annular region which are closer to the annular region than the atrial end 1802 of the second anterior tab A2.
  • the second anterior tab A2 will partially deploy first, followed by the first anterior tab Al and the posterior tab PTB concurrently, as the constraining sheath 1550 is retracted.
  • the lengths of the tabs and/or the axial positions of the atrial ends of the tabs may be varied such that one of the two anterior tabs Al , A2 is partially deployed before the posterior tab PTB.
  • the lengths of the tabs and/or the axial positions of the atrial ends of the tabs may be varied such that the second of the anterior tabs Al, A2 may be allowed to partially deploy before or after the full deployment of the posterior tab PTB.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • FIG. 18G the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • the first anterior tab Al may be longer than the second anterior tab A2 which may be longer than the posterior tab PTB, and/or the atrial end 1801 of the first anterior tab Al may be in an axial position away from the annular region further than the atrial end 1802 of the second anterior tab A2 which may be in an axial position further from the annular region than the atrial end 1803 of the posterior tab PTB.
  • the first anterior tab Al will partially deploy first, followed by the second anterior tab A2, and then followed by the posterior tab PTB, as the constraining sheath 1550 is retracted.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • FIG. 18H the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • the second anterior tab A2 may be longer than the first anterior tab Al which may be longer than the posterior tab PTB, and/or the atrial end 1802 of the second anterior tab A2 may be in an axial position away from the annular region further than the atrial end 1801 of the first anterior tab Al which may be in an axial position further from the annular region than the atrial end 1803 of the posterior tab PTB.
  • the second anterior tab A2 will partially deploy first, followed by the first anterior tab Al, and then followed by the posterior tab PTB, as the constraining sheath 1550 is retracted.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • the first anterior tab Al may be longer than the posterior tab PTB which may be longer than the second anterior tab A2, and/or the atrial end 1801 of the first anterior tab Al may be in an axial position away from the annular region further than the atrial end 1803 of the posterior tab PTB which may be in an axial position further from the annular region than the atrial end 1802 of the second anterior tab A2.
  • the first anterior tab Al will partially deploy first, followed by the posterior tab PTB, and then followed by the second anterior tab A2, as the constraining sheath 1550 is retracted.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • the second anterior tab A2 may be longer than the posterior tab PTB which may be longer than the first anterior tab Al, and/or the atrial end 1802 of the second anterior tab A2 may be in an axial position away from the annular region further than the atrial end 1803 of the posterior tab PTB which may be in an axial position further from the annular region than the atrial end 1801 of the first anterior tab Al.
  • the second anterior tab A2 will partially deploy first, followed by the posterior tab PTB, and then followed by the first anterior tab Al, as the constraining sheath 1550 is retracted.
  • the lengths of the tabs and/or the axial positions of the atrial ends of the tabs may be varied such that the posterior tab PTB is partially deployed first.
  • the lengths of the tabs and/or the axial positions of the atrial ends of the tabs may be varied such that the anterior tabs Al , A2 partially deploy either sequentially or concurrently after the partial deployment of the posterior tab PTB.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • FIG. 18K the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • the posterior tab PTB may be longer than the first anterior tab Al which may be longer than the second anterior tab A2, and/or the atrial end 1803 of the posterior tab PTB may be in an axial position away from the annular region further than the atrial end 1801 of the first anterior tab Al which may be in an axial position further from the annular region than the atrial end 1802 of the second anterior tab A2.
  • the posterior tab PTB will partially deploy first, followed by the first anterior tab Al and then the second anterior tab A2, as the constraining sheath 1550 is retracted.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • FIG. 18L the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • the posterior tab PTB may be longer than the second anterior tab A2 which may be longer than the first anterior tab Al, and/or the atrial end 1803 of the posterior tab PTB may be in an axial position away from the annular region further than the atrial end 1802 of the second anterior tab A2 which may be in an axial position further from the annular region than the atrial end 1801 of the first anterior tab Al .
  • the posterior tab PTB will partially deploy first, followed by the second anterior tab Al and then the first anterior tab Al, as the constraining sheath 1550 is retracted.
  • the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • FIG. 18M the distal edge 1650 of the constraining sheath 1550 is arranged to retract proximally in the direction of arrow AR2 parallel to the longitudinal axis of the valve during tab deployment.
  • the posterior tab PTB may be longer than the second anterior tab A2 which may the same length as the first anterior tab Al, and/or the atrial end 1803 of the posterior tab PTB may be in an axial position away from the annular region further than the atrial ends 1801, 1802 of the first anterior tab Al and second anterior tab A2 which may be in the same axial positions from the annular region.
  • the posterior tab PTB will partially deploy first, followed by the first anterior tab Al and the second anterior tab A2 concurrently, as the constraining sheath 1550 is retracted.
  • first and second anterior tabs Al, A2 and the posterior tab PTB may partially deploy before one or more of the first and second anterior tabs Al, A2 and the posterior tab PTB fully deploys.
  • Atrial deployment may be beneficial in certain situations. For example, atrial deployment allows the steadying of the heart while seating the prosthetic valve and can be easier to rotationally align the device with the native valve anatomy. Atrial deployment may also more evenly distribute force along the larger area of the atrial skirt instead of just along the three points of the anchor tabs.
  • a prosthetic valve which may be any of the prosthetic valves disclosed herein.
  • the prosthetic valve may be a prosthetic mitral valve or any of the other prosthetic valves disclosed herein.
  • One advantage of deploying the ventricular portion first in any of the prosthetic valves disclosed herein is that this allows recapture and redeployment of any of the anchor tabs in the situation where they are incorrectly deployed.
  • the anchor tabs may become entangled with chordae or the tip of the anchor tab may land on the inside of the valve annulus instead of behind the native valve leaflet.
  • the anchor tabs may not be correctly rotationally oriented with the native anatomy (e.g. the anterior portion of the prosthetic valve may not be rotationally aligned with the anterior of the native valve). And thus, it would be beneficial to be able to recapture and redeploy any or all anchor tabs so ensure that they are properly deployed.
  • ventricular height is not generally a concern.
  • Ventricular deployment also may require less occlusion time and may permit deployment without the use of rapid pacing. Ventricular deployment also may provide more opportunities to choose where the anchor tabs protrude past the chordae.
  • ventricular deployment may allow a reduction in the number of catheter shafts in the delivery system thereby decreasing overall profile of the catheter system (e.g. reduce French size).
  • Figs. 19A-19D illustrate a deployment sequence of a prosthetic valve.
  • the prosthetic valve 1903 is disposed in a lumen 1901 of a sheath 1901.
  • the sheath constrains the prosthetic valve 1903 which also constrains a first anchor tab 1907 and a second anchor tab 1905 coupled to the prosthetic valve frame adjacent a ventricular region of the frame.
  • the first anchor tab 1907 is an anterior anchor tab configured to extend through the chordae tendinae and behind the anterior native valve leaflet such that the tip of the anchor tab engages and anchors the prosthetic valve to the fibrous trigone.
  • a second anterior tab may also be included (not shown) and it also may be configured to extend through the chordae tendinae and behind the anterior native valve leaflet such that the tip of the second anterior anchor tab engages and anchors the prosthetic valve to a second fibrous trigone opposite the other fibrous trigone.
  • the other anchor tab 1905 is preferably a posterior anchor tab that is configured to extend through any chordae tendinae and behind the posterior native valve leaflet such that the tip of the posterior anchor tab engages and anchors the prosthetic valve to a posterior portion of the native valve annulus, such as the posterior shelf.
  • the anterior and posterior anchor tabs generally take the same form as those previously described above.
  • the anterior or posterior native valve leaflets may be disposed at least partially between the respective anchor tab and an outer surface of the prosthetic valve.
  • the anchor tabs may take the same form as any of the other anchor tabs disclosed herein.
  • Fig. 19B illustrates proximal retraction of the sheath 1901 away from the prosthetic valve 1903 thereby removing the constraint from the two anchor tabs 1905, 1907 thereby allowing them to self-expand first.
  • Fig. 19C further proximal retraction of the sheath 1901 exposes an additional distal portion of the prosthesis 1903 thereby removing a constraint from the ventricular portion of the prosthesis such that the ventricular skirt 1911 may self-expand.
  • the ventricular skirt 1911 is substantially the same as other ventricular skirts described in this specification.
  • FIG. 19D further proximal retraction of the sheath 1901 exposes the entire prosthesis 1903 and removes the constraint provided by the sheath 1901 thereby allowing the annular region and the atrial flange 1913 to self-expand.
  • the anchor tabs self-expand and deploy first followed by the ventricular skirt thereby helping to anchor the prosthesis to the native heart valve, here a native mitral valve from the ventricular side first followed by the atrial side.
  • the prosthesis may also be balloon expandable or expandable by other means known in the art.
  • Figs. 20A-20E illustrate an example of this.
  • Fig. 20A the prosthetic valve 2003 is disposed in a lumen 2009 of sheath 2001.
  • the sheath constrains the prosthesis and prevents it from self expanding as well as protects it during delivery.
  • the prosthesis also includes a first anchor tab 2007 and a second anchor tab 2005. Both anchor tabs are also constrained by the sheath 2001 which prevents them from expanding and provides protection during delivery.
  • proximal retraction of sheath 2001 exposes the first anchor tab 2007 allowing it to self-expand while maintaining adequate constraint of the ventricular skirt and the second anchor tab 2005 to prevent expansion thereof.
  • the first anchor tab is preferably an anterior anchor tab that is configured to engage and anchor on the fibrous trigone of a native mitral valve, substantially the same as described previously. It may expand into a
  • the prosthetic valve may also have a second anterior tab as described above.
  • FIG. 20C Further retraction as shown in Fig. 20C exposes the second anchor tab 2005 and allows it to self-expand while maintaining adequate constraint over the ventricular skirt to prevent it from expanding.
  • the second anchor tab 2005 may initial expand into a substantially horizontal position and then expand into a substantially vertical position as shown.
  • the second anchor tab is preferably a posterior anchor tab configured to engage and anchor on the posterior annulus of a native mitral valve as described previously.
  • tab axial position, length, cross-section, heat treatment, etc. can be programmed into the prosthesis to control the expansion sequence.
  • Fig. 20E further retraction of sheath 2001 removes the constraint from the remainder of the prosthetic valve 2003 thereby allowing the annular region and the atrial flange 2013 to self-expand.
  • the annular region and the atrial flange generally take the same form as previously described in this specification.
  • the anchor tabs self-expand serially followed by the ventricular skirt thereby helping to anchor the prosthesis to the native heart valve, here a native mitral valve is deployed from the ventricular side first followed by the atrial side.
  • the prosthesis may also be balloon expandable or expandable by other means known in the art.
  • FIGs. 21 A-21E illustration a variation in Figs. 20A-20E where the second anchor tab deploys before the first anchor tab.
  • a prosthetic valve 2103 is disposed in a lumen 2109 of a sheath 2101 thereby constraining the prosthetic valve 2102.
  • the first anchor tab 2107 and the second anchor tab 2105 are also constrained by the sheath 2101 and prevented from expanding.
  • proximal retraction of the sheath 2101 removes the constraint from the second anchor tab 2105 allowing it to self-expand. It may initially extend horizontally outward and then self-expand into a substantially vertical position as shown. The first anchor tab 2017 remains constrained and does not self-expand.
  • Fig. 21C shows that further proximal retraction of the sheath
  • the first anchor tab may initially self- expand into a substantially horizontal position and then fully expand into a substantially vertical position as shown.
  • Fig. 21E shows that further retraction of sheath 2101 removes the constraint from the remainder of the prosthesis 2103 allowing the annular region and the atrial flange 2113 to self-expand.
  • first anchor tab is an anterior anchor tab and preferably the second anchor tab is a posterior anchor tab, both tabs generally take the same form as discussed previously in this specification.
  • the prosthesis may also have a second anterior anchor tab as also discussed above.
  • anchor tab length, axial position, cross-section, etc. affect the sequence of deployment and these can be selected during manufacturing in order to provide the desired deployment sequence.
  • the delivery system may be engineered to preferentially allow selected regions of the prosthesis to expand in an order as illustrated in Figs. 22A-22B.
  • a prosthesis which may be any of those disclosed herein is disposed in a sheath 2201.
  • the sheath constrains the tip of the anchor tab 2207 but also has a slotted region 2203 extending parallel to the longitudinal axis of the sheath.
  • proximal retraction of the sheath as seen in Fig 22B allows the constraint to be removed from the anchor tab 2207 first thereby allowing the anchor tab to self-expand before other portions of the prosthesis.
  • Fig. 22B is the same form as in Fig. 22A except that it has been rotated 90 degrees to show a side view of the anchor tab deployed.
  • the slotted regions may be located at any position on the sheath to control the constraint and expansion of any portion of the prosthesis such as the anchor tabs or other regions.
  • the anchor tabs expand before the ventricular skirt.
  • Figs. 23A-23C illustrate an example of ventricular skirt deployment.
  • a prosthetic valve 2305 is disposed in a lumen 2303 of a sheath 2301.
  • the sheath 2301 constrains the prosthetic valve 2305 and prevents expansion of the prosthesis including the first anchor tab 2309 and the second anchor tab 2307.
  • the prosthesis is any of the mitral valve prostheses described in this specification.
  • the first anchor tab 2309 is an anterior anchor tab and the second anchor tab 2307 is a posterior anchor tab such as those described in this specification.
  • the prosthesis may also have a second anterior anchor tab that is not illustrated because it is not seen in this view.
  • Anchor tab axial position, length, cross-section, etc. affect the sequence of deployment.
  • the anchors are positioned such that proximal retraction of sheath 2301 removes the constraint from the ventricular skirt allowing ventricular skirt 2311 to self-expand first as shown in Fig. 23B.
  • any number of delivery systems may be used to help control deployment of the prosthesis.
  • a hollow capsule may be used to carry the prosthesis to the treatment site and then the capsule may be opened to allow deployment in a desired sequence.
  • Capsule delivery systems are disclosed in US Patent Publication No. 2017/0165064, the entire contents of which are incorporated herein by reference. While the capsules disclosed in US Patent Publication No. 2017/0165064 generally provide for atrial deployment of a prosthesis first, one of skill in the art will appreciate that they can be modified to provide for ventricular deployment of a prosthesis first.
  • FIGs. 24A-24C illustrate an example of a capsule delivery system used to deliver a prosthetic valve with ventricular deployment first.
  • Fig. 24A illustrates a prosthetic valve 2411 disposed in a hollow capsule 2405.
  • the capsule carries the prosthesis to the target treatment area and protects it during delivery as well as providing a constraint to keep the prosthesis in a collapsed configuration and prevent self-expansion.
  • the prosthesis is preferably a prosthetic mitral valve and may be any of the examples disclosed herein.
  • the hollow capsule 2405 includes a proximal portion 2407 and a distal portion 2409.
  • An inner shaft 2403 is coupled with the distal capsule portion 2409 and an outer shaft 2401 is coupled to the proximal capsule portion 2405.
  • the inner and outer shafts slide relative to one another.
  • the proximal and distal portions of the capsule are separable from one another as will be discussed below.
  • Fig. 24B the distal capsule portion 2409 is moved distally relative to the proximal capsule portion 2405 (and/or the proximal capsule portion 2407 is moved proximally relative to the distal capsule portion) to separate the two halves and remove the constraint from the ventricular region of the prosthetic valve 2411 thereby allowing the ventricular skirt 2417 to self- expand while the first and second anchor tabs 2415, 2417 remain constrained and do not self-expand as well as the atrial and annular portions.
  • the capsule halves may be moved by relative movement of the inner shaft 2403 or outer shaft 2401.
  • Fig. 24C further separation of the proximal and distal capsule portions further removes the constraint from the prosthetic valve allowing the first and second anchor tabs 2415, 2417 to self-expand. Further separation of the capsule halves will then allow the annular region and the atrial flange to self- expand (not shown).
  • the first anchor tab is an anterior anchor tab and the second anchor tab is preferably a posterior anchor tab.
  • the prosthetic valve also includes a second anterior anchor tab.
  • the anchor tabs generally take the same form as discussed above. Moreover, any deployment sequence of the anchor tabs may be used in this example including those described previously.
  • Fig. 25A shows a delivery system having a capsule 2505 for carrying a prosthetic valve 2511.
  • the capsule includes a proximal capsule portion 2507 and a distal capsule portion 2509 that are separable from one another.
  • An inner shaft 2503 is coupled to the distal capsule portion 2509 and an outer shaft 2501 is coupled with the proximal capsule portion 2505.
  • the inner and outer shafts 2501, 2503 slide relative to one another.
  • the distal capsule portion is separated from the proximal capsule portion 2507 to remove the constraint from a portion of the prosthetic valve 2511 thereby allowing the anchor tabs 2515, 2513 to self- expand while the ventricular skirt 2517 remains constrained.
  • the first anchor tab 2515 is an anterior anchor tab and preferably the second anchor tab 2513 is a posterior anchor tab.
  • the prosthetic valve may include a second anterior anchor tab (not shown).
  • the first and second anchor tabs may take the form of any anchor tabs previously described above.
  • proximal and distal capsules 2507, 2509 allow the ventricular skirt 2517 to become unconstrained and to self-expand next as seen in Fig. 25C.
  • the remainder of the prosthetic valve expands with further separation of the capsule halves including the annular region and the atrial flange last (not illustrated).
  • Fig. 25D1 shows a delivery system having a distal capsule portion 2601 and proximal capsule portion 2505 for carrying a prosthetic valve 1506 and constraining the atrial portion of the prosthetic valve from deploying first while allowing the ventricular portion to deploy first.
  • An inner shaft 2518 is coupled to the distal capsule portion 2601.
  • the distal capsule portion 2601 contains a proximal edge with a straight proximal edge 2325.
  • Fig 25D2 shows the three-dimensional sketch and the two-dimensional sketch of the straight proximal edge 2325. This straight edge 2325 allows for controlled deployment of the first anterior anchor tab Al, the second anterior anchor tab A2, and the proximal anchor tab (not illustrated, if present).
  • the ventricular anchors include tabs 2324 which engage with a slotted disc to constrain ventricular deployment.
  • the proximal and distal capsule portions may be separated so that the first anterior anchor tab Al deploys before the second anterior anchor tab A2 and the posterior anchor tab (not illustrated).
  • the second anterior anchor tab A2 may be deployed before the first anterior anchor tab Al and the posterior anchor tab (not illustrated).
  • the posterior anchor tab (not illustrated) may deploy before the first anterior anchor tab Al and second anterior anchor tab A2.
  • the first anterior anchor tab Al and the second anterior anchor tab A2 deploy simultaneously before the posterior anchor tab (not illustrated).
  • the first anterior anchor tab Al, the second anterior anchor tab A2, and the posterior anchor tab (not illustrated) deploy simultaneously.
  • the distal capsule portion 2601 is actuated by pushing the inner shaft 2518 coupled to the distal capsule portion 2601 distally, thereby separating the distal capsule portion 2601 from the proximal capsule portion 2505.
  • a second inner shaft (not illustrated) may be coupled to the proximal capsule portion 2505 wherein pulling the second inner shaft separates or removes the proximal capsule portion from the distal capsule portion after the ventricular deployment.
  • Fig. 25E1 shows another example of a delivery system with a proximal capsule portion 2505 and a distal capsule portion 2602 where the distal capsule portion is partially separated from the prosthetic valve 1506, to remove the constraint from a portion of the prosthetic valve thereby allowing the anterior tabs Al, A2 to expand.
  • the distal capsule portion 2602 has a proximal edge with a slanted edge 2326 relative to the longitudinal axis of the capsule.
  • Fig 25E2 shows the three-dimensional sketch and the two-dimensional sketch of the slanted proximal edge 2326.
  • the slanted edge 2326 allows for the controlled deployment of the first anterior anchor tab Al, second anterior anchor tab A2, and the posterior anchor tab (not illustrated).
  • the distal capsule portion 2602 or the proximal capsule portion 2505 may be separated in which the first anterior anchor tab Al deploys before the second anterior anchor tab A2 and the posterior anchor tab (not illustrated).
  • the second anterior anchor tab A2 may be deployed before the first anterior anchor tab Al and the posterior anchor tab (not illustrated).
  • the posterior anchor tab (not illustrated) may deploy before the first anterior anchor tab Al and second anterior anchor tab A2.
  • the first anterior anchor tab Al and the second anterior anchor tab A2 deploy simultaneously before the posterior anchor tab (not illustrated).
  • the first anterior anchor tab Al, the second anterior anchor tab A2, and the posterior anchor tab (not illustrated) deploy simultaneously.
  • the ventricular anchors include tabs 2324 that engage with the slotted disc to constrain deployment thereof.
  • Other aspects of the prosthetic valve and capsule generally take the same form as previously disclosed herein.
  • the proximal capsule may be retracted proximally away from the atrial portion of the prosthetic valve after ventricular deployment to allow the atrial portion to expand.
  • Fig. 25F1 shows yet another example of a delivery system with a proximal capsules portion 2505 and a distal capsule portion 2518 wherein removing the distal capsule constraint from a portion of the prosthetic valve allows the anterior tabs Al, A2 to expand while the atrial portion is constrained.
  • the distal capsule portion 2603 has a proximal edge with an undulating or corrugated edge 2327 along the proximal edge of the distal capsule portion.
  • Fig 25F2 shows the three-dimensional sketch and the two-dimensional sketch of the proximal undulating or corrugated edge 2327. The undulating or corrugated edge 2327 allows for the controlled deployment of the first anterior anchor tab Al, the second anterior anchor tab A2, and the posterior anchor tab.
  • the capsule may be separated in which the first anterior anchor tab Al deploys before the second anterior anchor tab A2 and the posterior anchor tab (not illustrated).
  • the second anterior anchor tab A2 may be deployed before the first anterior anchor tab Al and the posterior anchor tab (not illustrated).
  • the posterior anchor tab (not illustrated) may deploy before the first anterior anchor tab Al and second anterior anchor tab A2.
  • the first anterior anchor tab Al and the second anterior anchor tab A2 deploy simultaneously before the posterior anchor tab (not illustrated).
  • the first anterior anchor tab Al, the second anterior anchor tab A2, and the posterior anchor tab (not illustrated) deploy simultaneously.
  • the peaks and valleys of the undulations may be adjusted thereby controlling the constraint provided to the prosthesis and therefore controlling the deployment sequence.
  • the proximal capsule may be retracted proximally to unconstrain the proximal portion of the prosthesis thereby allowing the atrial portion to self-expand after the ventricular portion.
  • Fig 25 G shows yet another example of a delivery system with a proximal capsule portion 2505 and a distal capsule portion 2604 wherein removing the distal capsule constraint from a portion of the prosthetic valve allows the anterior tabs Al, A2 to expand while the atrial portion is constrained.
  • the capsule may be separated in which the first anterior anchor tab Al deploys before the second anterior anchor tab A2 and the posterior anchor tab (not illustrated).
  • the second anterior anchor tab A2 may be deployed before the first anterior anchor tab Al and the posterior anchor tab (not illustrated).
  • the posterior anchor tab (not illustrated) may deploy before the first anterior anchor tab Al and second anterior anchor tab A2.
  • Fig 25H shows that further advancement of the distal capsules releases the second anchor tab in Fig. 25G.
  • proximal capsule portion 2505 and a distal capsule portion 2606 are separable and removing the distal capsule constraint from a portion of the prosthetic valve allows the second anterior tab to deploy while the atrial portion is still constrained.
  • the first anterior anchor tab Al and the second anterior anchor tab A2 deploy
  • Fig. 251 shows part of a delivery system with an elongate shaft
  • the commissure control element may have one or more commissure control slots 2522 extending radially inward or outward and the elbow control element may have one or more elbow control slots 2521 that extend radially inward or outward.
  • the slots are sized and shaped to receive a portion of the commissure tabs or anchor tab elbows so they may be constrained in position and held until an outer sheath or capsule is retracted or the elongate shaft 2518 is advanced distally to remove the constraint and allow the commissure tabs and/or the anchor tab elbow to radially expand.
  • Actuation of the commissure control element or the elbow control element may be controlled in any desired order in order to release the commissure tabs and the anchor tab elbows in any desired order.
  • the commissure tabs may be released first then the elbows, or the elbows first then the commissure tabs, or the commissure tabs and the elbows may be released concurrently as discussed below.
  • Fig. 25J further shows the delivery system and its interaction with the prosthetic valve 1506.
  • the elbow control element 2519 comprises at least two elbow control slots wherein anterior anchor tabs Al and A2 contain protrusions (also referred to as tabs) 2523 and 2519 respectively.
  • the protrusions 2523 and 2519 are disposed into the slots 2521 and constrained by an outer sheath or a portion of the capsule, wherein upon release Al, or A2, or both expands.
  • Al may expand first
  • A2 may expand first
  • Al and A2 may expand simultaneously.
  • the commissure control element 2520 also contains one or more commissure control slots 2522 wherein a commissure control protrusion 2324 may be disposed into the one or more slots.
  • the commissure control element may release the one or more tabs before the elbow control element, or the elbow control element may release the one or more tabs before the commissure control element, or the commissure control element and elbow control element may release simultaneously.
  • the elbow control element 2519 may be deployed in which the first anterior anchor tab Al deploys before the second anterior anchor tab A2 and the posterior anchor tab (not illustrated) as well as before the commissure control element releasing the commissure tabs.
  • the second anterior anchor tab A2 may be deployed before the first anterior anchor tab Al and the posterior anchor tab (not illustrated).
  • the posterior anchor tab (not illustrated) may deploy before the first anterior anchor tab Al and second anterior anchor tab A2.
  • first anterior anchor tab Al and the second anterior anchor tab A2 deploy simultaneously before the posterior anchor tab (not illustrated.
  • first anterior anchor tab Al, the second anterior anchor tab A2, and the posterior anchor tab (not illustrated) deploy simultaneously.
  • the commissure control element coupled to the inner shaft and connected to the commissure tabs can deploy the commissure tabs (not illustrated) before the first anterior anchor tab Al, second anterior anchor tab A2, and posterior anchor tab (not shown).
  • the atrial skirt may deploy first, followed by the ventricular skirt, then any or all of the anchor tabs in any sequence.
  • the ventricular skirt may deploy first, followed by the atrial skirt then the anchor tabs in any sequence.
  • the anchor tabs may deploy in any sequence followed by the ventricular skirt then the atrial skirt.
  • the ventricular skirt may be deploy first followed by the anchor tabs in any sequence then followed by the atrial skirt.
  • trans-septal delivery system 1 for trans-catheter heart valve delivery is depicted generally as 1.
  • the trans-septal delivery system 1 can comprise a prosthesis such as a prosthesis capsule or valve capsule assembly 8, a delivery catheter assembly 7, a steering guide 10, a delivery handle assembly 4, and an interface 9 between the delivery handle 4 and steering handle 5.
  • the steering guide 10 can be comprised of a steerable catheter assembly 6 and a steering handle 5.
  • the valve capsule assembly 8 can be in operable communication with the delivery handle assembly 4 by way of the delivery catheter assembly 7 which extends therebetween.
  • the translational position and angular attitude of the prosthesis or valve capsule assembly 8 can be operably controlled by the steering handle 5 and in communication by way of the steerable catheter assembly 6 which extends therebetween.
  • the interface 9 can be comprised of a slidable seal, such as an O-ring type seal.
  • the interface 9 can further function to allow the delivery handle or delivery catheter to translate within the steering handle while maintaining some Stiction, thus preventing blood or other fluid from seeping out of the steering handle should such blood or fluid make its way up the steering catheter assembly.
  • delivery handle assembly 4 includes a distal actuator such as a thumb wheel 11 and a proximal actuator such as a thumb wheel 12, both of which are integrally associated with the delivery handle assembly 4, which is comprised of an A-side delivery handle housing 22 and a B-side delivery handle housing 23.
  • Distal thumbwheel 11 and proximal thumb wheel 12 are also rotatably positionable with respect to the delivery handle assembly 4, serving as actuators by way of internal threads (not shown) and enabling translational control of various catheters within the delivery catheter assembly 7, further evidence of which will be detailed in a later section.
  • the delivery handle assembly 4 is operatively coupled to the valve capsule assembly 8 via the delivery catheter assembly 7, which functions in one aspect as a motion translation agent.
  • the delivery handle assembly 4, delivery catheter assembly 7 and valve capsule assembly 8 can form a delivery system 26.
  • the steering handle 5 and steer able catheter assembly 7 can form a steering guide 10, which provides a path through which the delivery system 26 can translate and rotate, and from which it may take its shape in order to traverse tortuous vasculature during implantation. Taken altogether, the delivery system 26 and steering guide 10 can form the trans- septal delivery system 1.
  • Valve capsule assembly 8 may exhibit various constructions.
  • the distal capsule 14 and proximal capsule 13 may be formed from substantially rigid, stainless steel, polymer, metal or otherwise rigid tubing, from collapsible, flexible tubing, or from shape-settable exotic metal alloys which exhibit shape memory characteristics and are actuated by temperature gradients inherent to the human physiology, such as nitinol.
  • portions of the valve capsule assembly 8 can be translatably controlled by the turning of either the distal thumbwheel 11 , or the proximal thumbwheel 12, located in the delivery handle assembly 4.
  • the proximal capsule 14 By rotating the distal thumbwheel 11, the proximal capsule 14 can be translatably positioned along the axis of the capsule assembly 8 in order to reveal certain portions of the prosthesis such as a prosthetic mitral valve for example.
  • the proximal capsule 13 By rotating the proximal thumb wheel 12, the proximal capsule 13 can be translatably positioned along the axis of the valve capsule assembly 8, again preferably revealing and releasing certain portions of the prosthetic valve (not shown).
  • Capsule variations will be described in detail in a later section. Any capsule examples may be used with any of the deployment sequences disclosed previously.
  • the delivery catheter assembly 7 is generally comprised of a family of nested catheters concentrically and slidably disposed over one another.
  • the innermost catheter in the family of nested catheters is the guidewire catheter 30 which has a distal section 32 that is coupled to the distal capsule 14, and a proximal section 31, with a guidewire lumen 33 that is generally sized to accept a guidewire running therebetween.
  • the guidewire catheter 30 has a constant outer diameter and a constant inner diameter throughout its entire length, as well as a flexible section 300 which allows for articulation.
  • the guidewire catheter 30 is generally configured to be able to fit inside of and translate slidably with respect to the bell catheter 34.
  • the bell catheter 34 has a distal section360 that is coupled to a bell 36, wherein the bell can be generally cylindrically shaped having a diameter larger than the bell catheter, and a proximal section 35, with an inner lumen 361 that is generally sized to accept the guidewire catheter 30 running therebetween.
  • the bell catheter 34 has a constant outer diameter and a constant inner diameter throughout its entire length, as well as a flexible section 301 which allows for articulation.
  • the bell catheter 34 is generally configured to be able to fit inside of and slidably translate with respect to the anchoring catheter 37.
  • the anchoring catheter 37 has a distal section 39 that is coupled to an anchor 400, wherein the anchor can be generally cylindrically shaped and have a plurality of anchoring slots circumferentially positioned to receive valve commissure anchoring portions (not shown), and a proximal section 38, with an inner lumen 40 that is generally sized to accept the bell catheter 34 running therebetween.
  • the anchoring catheter 37 has a constant outer diameter and a constant inner diameter throughout its entire length, as well as a flexible section 302 which allows for articulation.
  • the anchoring catheter 37 is generally configured to be able to fit inside of and translate with respect to the sheath catheter 41.
  • the sheath catheter 41 has a distal section 43 that is coupled to the proximal capsule 13, wherein the proximal capsule can have a cylindrical portion terminating in a cap portion, and wherein the cap portion can have a rounded dome-like Surface, and a proximal section 42, with an inner lumen 130 that is generally sized to accept the anchoring catheter 37 running therebetween.
  • the sheath catheter 41 has a constant outer diameter and a constant inner diameter throughout its entire length, as well as a flexible section 303 which allows for articulation.
  • the sheath catheter 41 is generally configured to be able to fit inside of and slidably translate with respect to the steering catheter assembly 6.
  • the steering catheter assembly 6 is comprised of a steerable catheter 309, a pull ring 307, wherein the pull ring can have a circular ring-like shape located at the distal section 305 of the catheter, a plurality of pull wires 308 located at the proximal section of the catheter, a flexible section 304 that allows for articulation, and an inner lumen 310 running throughout the entire length. For each pull wire 308 there is a corresponding lumen (not shown) that runs the entirety of the steerable catheter 309.
  • the steering guide 10 includes an interface section 9 that is comprised of an O-ring type interface of cylindrical shape similar to a gasket, which is embedded within A and B side steering handle housings 24 and 25 respectively, the A-side steering handle housing 24, the B-side steering handle housing 25, an actuator such as a steering thumbwheel 16, wherein the steering thumb wheel can have a generally cylindrical shape, a catheter strain relief 27, and a steerable catheter assembly 6.
  • the steering thumbwheel can additionally include one or more protrusions separated by one or more recesses or slots to provide a surface to facilitate grasping and turning the wheel.
  • the steering thumbwheel can have a textured surface with ribs to facilitate grasping and turning the wheel.
  • the interface section 9 provides a dynamic seal between the steering handle 5 and the delivery catheter assembly 7 thus allowing for slidably sealed catheter translation thereby; the delivery catheter assembly thus may traverse therethrough and exit towards the distal end of the steering guide 10 at the terminal, articulated end 15 of the steerable catheter assembly 6. While the interface section 9 provides a dynamic seal, the delivery catheter assembly 7 may still translate and rotate within the steering guide 10, in order to define accurate positioning within a patient, at the target implant site. Detail regarding the implant procedure and target implant site will be discussed in a later section.
  • the steering thumbwheel 16 is turned. When the steering thumbwheel 16 is turned, the articulated end 15 of the steerable catheter assembly 6 will bend in the same direction as the direction of thumbwheel turning.
  • This motion translation is achieved through the use of internal pull wires 308, as depicted for example in FIG. 31, that are distally in mated connection (such as a welded connection, or using fasteners, or adhesives, or any suitable method of fastening) with a pull ring 307, and proximally connectably communicate with the internal mechanisms which are inherent to the steering handle 5 and will be described in further detail in a later section.
  • internal pull wires 308 as depicted for example in FIG. 31, that are distally in mated connection (such as a welded connection, or using fasteners, or adhesives, or any suitable method of fastening) with a pull ring 307, and proximally connectably communicate with the internal mechanisms which are inherent to the steering handle 5 and will be described in further detail in a later section.
  • FIG. 27A describes a general depiction of a partial view (with anterior ventricular surface, pulmonary trunk, and aorta removed) of a human heart.
  • the steering guide 7 will follow a guidewire 811 that has previously been placed in order to provide a path that leads to the target implant site.
  • the steering guide 7 will enter the inferior vena cava 810 by way of the descending inferior vena cava (not shown) and first an incision at the femoral vein near the groin (not shown).
  • the steering guide 7 will then exit the inferior vena cava 810 through a caval foramen 801 which acts as an inlet to the right atrium 802 (FIG. 27B).
  • the steering guide 10 will then penetrate the foramen ovale 803 in the septal wall and gain access to the left atrium 804.
  • the steering guide 10 will be aimed towards the mitral annulus 805 in order to provide a direct channel towards the implant site (mitral annulus 805) for the delivery catheter 812 (FIG. 27D) to operate within.
  • FIG. 28 illustrates an example of an assembly of a trans-septal delivery system 1 shown in exploded view.
  • the trans-septal delivery system 1 is displayed in sections in order to make description of the internal parts more easily understood.
  • Delivery handle section 403 will be described in further detail below with reference to FIG. 29.
  • Steering handle section 402 will be described in further detail below with reference to FIG. 30.
  • delivery catheter section 401 has previously been described above with reference to FIG. 31.
  • the delivery handle section 403 is generally comprised of an A-side delivery handle housing 22 that is in mating connection with a B-side delivery handle housing 23, actuators such as a plurality of thumbwheels (distal thumb wheel 11 and proximal thumb wheel 12), a plurality of force transferring leadscrews (distal leadscrew 503 and proximal leadscrew 511) that may trans late proximally or distally depending on the rotation of the thumbwheel within said plurality of thumbwheels, a plurality of hemostatic ports and related tubing which provide the ability to remove entrained air boluses from concentrically nested catheters within the system, and various other components and fasteners that shall be described in further detail.
  • actuators such as a plurality of thumbwheels (distal thumb wheel 11 and proximal thumb wheel 12), a plurality of force transferring leadscrews (distal leadscrew 503 and proximal leadscrew 511) that may trans late proximally or distally depending on the
  • a distal leadscrew 503 is in threaded connection with a distal thumbwheel 11 and by turning said distal thumbwheel 11, translational motion is imparted upon the distal leadscrew 503.
  • the motion of the distal leadscrew 503 is transferred to the sheath catheter 41 by way of a connection between the proximal end 42 of the sheath catheter 41 and the distal end 5010 of the distal leadscrew cap 501, which itself is mated with adhesive (medical grade UV cure adhesive, or medical grade cyanoacrylate adhesive, or any suitable medical grade adhesive for plastics or polymers, etc.) to the distal lead screw 503.
  • adhesive medical grade UV cure adhesive, or medical grade cyanoacrylate adhesive, or any suitable medical grade adhesive for plastics or polymers, etc.
  • the distal leadscrew cap 501 also permits the ejection of air by way of a sealed interface (distal O-ring 502) between the sheath catheter 41 and the anchoring catheter 37.
  • a stationary screw cap 504 is entrained within the A and B side handle housings 22, 23 respectively, and provides location and retention for the anchoring catheter 37, whereby the proximal end 38 of the anchoring catheter 37 is in mated connection (medical grade UV cure adhesive, or medical grade cyanoacrylate adhesive, or any suitable medical grade adhesive for plastics or polymers, or by way of fastening mechanical threads) with the distal end 5040 of the stationary screw cap 504.
  • the stationary screw cap 504 also permits the ejection of air by way of a sealed interface (medial O-ring 505) between the anchoring catheter 37 and the bell catheter 34.
  • a proximal leadscrew 511 is in threaded connection with a proximal thumb wheel 12 and by turning said proximal thumb wheel 12, translational motion is imparted upon the proximal leadscrew 511. The motion of the proximal leadscrew 511 is transferred to the guidewire catheter 30 by way of a connection between the proximal end 31 of the guidewire catheter 30 and the distal end 5110 of the proximal leadscrew 511.
  • Proximal leadscrew 511 motion is also transferred to the bell catheter 34 by way of a slidable interference between the distal end 5110 of the proximal leadscrew 511 and the proximal leadscrew plate 510, whereby the proximal leadscrew plate 510 is in mated connection with the proximal leadscrew cap 508, and the proximal leadscrew cap 508 houses the proximal end 35 of the bell catheter 34.
  • the proximal leadscrew cap 508 also permits the ejection of air by way of a sealed interface (proximal O-ring 509) between the bell catheter 34 and the guidewire catheter 30.
  • the steering handle section 402 is generally comprised of an A-side steering handle housing 24 that is in mating connection with a B-side steering handle housing 25, a steerable catheter assembly 6 that is in mating connection with a catheter strain relief 27, an interface 9, a plurality of rotatable disks (B-side rotatable disk 600 and A-side rotatable disk 607), a steering thumb wheel 16, a push button 613, and various other components and fasteners that shall be described in further detail.
  • a steering thumbwheel 16 is in mating connection with a locking hub 608 that is centered within the A-side rotatable disk 607.
  • the A-side rotatable disk 607 and B-side rotatable disk 600 are coupled together by way of a plurality of carrier rods 601, and work mechanically to spin within the handle housing that is comprised of the A-side steering handle housing 24 and B-side steering handle housing 25. Since the A-side rotatable disk 607 is connected to the steering thumbwheel 16, rotation of the steering thumb wheel 16 causes rotation of the A-side rotatable disk 607.
  • a specific function of the plurality of rotatable disks (B-side rotatable disk 600 and A-side rotatable disk 607) is to actuate the plurality of pull wires 308 by way of tensioning hinges 602 that may spin freely on the carrier rods 601 and that are also connected to the pull wires 308 and also apply tension to them when turned.
  • a push button 613 is in threaded connection with a push button pin 611 that acts as a shaft.
  • the push button 613 is located within a cavity 6131 that allows for direct translation when the button is depressed.
  • a push button spring 612 is housed between the inside surface of the push button 613, and the bottom of the cavity 6131 and provides return force for when the depressed push button 613 is released. Motion from the pushbutton 613 is transferred along the pushbutton pin 611 directly to a cross bar 604 that is fastened to the push button pin 611 by way of a setscrew 605. When the push button pin 611 translates as the pushbutton 613 is depressed, the cross bar 604 also translates and a plurality of cross bar pegs 6041 that are located on the ends of the cross bar 604 thus translate as well.
  • the cross bar pegs 6041 When in an un-depressed state, the cross bar pegs 6041 are seated within a plurality of slots 6071 that appear on the periphery of the A-side rotatable disk 607. The cross bar pegs 6041 then also project through the slots 6071 and may rest within any of the circumferential slits 610 that appear in an array about the periphery of a position disk 609 that is mounted to the inside surface of the A-side steering handle housing 24 by threaded fasteners 606.
  • the cross bar pegs 6041 When in a depressed state, the cross bar pegs 6041 are moved away from the circumferential slits 610 until clearance is achieved, and the locking mechanism enables free rotation of the cross bar 604, as well as all aspects that are directly connected to the A-side rotatable disk 607.
  • Example 1 is a method of delivering a prosthetic valve to a native mitral valve of patient’s heart, the native mitral valve having a native anterior leaflet and a native posterior leaflet, the method comprising: providing a prosthetic valve comprising a ventricular portion and an atrial portion, wherein the ventricular portion comprises a ventricular skirt, an anterior anchoring tab disposed on the ventricular skirt, a posterior anchoring tab disposed on the ventricular skirt, and wherein the atrial portion comprises an atrial flange;
  • Example 2 is the method of Example 1, wherein radially expanding the ventricular portion comprises deploying the anterior anchoring tab before deploying the posterior anchoring tab and before the ventricular skirt.
  • Example 3 is the method of any of Examples 1-2, wherein radially expanding the ventricular portion comprises deploying the posterior anchoring tab before deploying the anterior anchoring tab and before the ventricular skirt.
  • Example 4 is the method of any of Examples 1-3, wherein radially expanding the ventricular portion comprises deploying the ventricular skirt before deploying the anterior anchoring tab and before the posterior anchoring tab.
  • Example 5 is a prosthetic valve comprising: a ventricular portion comprising a ventricular skirt, an anterior anchoring tab disposed on the ventricular skirt, and a posterior anchoring tab disposed on the ventricular skirt; and an atrial portion comprising an atrial flange, wherein the ventricular portion is configured to radially expand first, and wherein the atrial portion is configured to radially expand after the ventricular portion.
  • Example 6 is the prosthetic valve of Example 5, wherein the radial expansion of the ventricular portion deploys the anterior anchoring tab before the posterior anchoring tab and the ventricular skirt.
  • Example 7 is the prosthetic valve of any of Examples 5-6, wherein the radial expansion of the ventricular portion deploys the posterior anchoring tab before the anterior anchoring tab and the ventricular skirt.
  • Example 8 is the prosthetic valve of any of Examples 5-7, wherein the radial expansion of the ventricular portion deploys the ventricular skirt before the anterior anchoring tab and the posterior anchoring tab.
  • Example 9 is a method of delivering a prosthetic valve to a native mitral valve of patient’s heart, the native mitral valve having a native anterior leaflet and a native posterior leaflet, the method comprising: providing the prosthetic valve comprising a ventricular portion and an atrial portion, wherein the ventricular portion comprises a ventricular skirt, an anterior anchoring tab disposed on the ventricular skirt, a posterior anchoring tab disposed on the ventricular skirt, and wherein the atrial portion comprises an atrial flange;
  • the prosthetic valve is coupled to a distal portion of the delivery system; actuating the distal portion of the delivery system thereby removing a constraint from the prosthetic valve; radially expanding the ventricular portion first; and radially expanding the atrial portion after the ventricular portion.
  • Example 10 is the method of Example 9, wherein the distal portion of the delivery system further comprises a capsule comprising a distal capsule portion and a proximal capsule portion, and wherein actuating the distal portion of the delivery system comprises moving the proximal capsule portion away from the distal capsule portion.
  • Example 11 is the method of any of Examples 9-10, wherein the delivery system further comprises an elongate shaft coupled to the distal capsule, and wherein moving the elongate shaft distally moves the distal capsule portion thereby unconstraining the ventricular portion.
  • Example 12 is the method of any of Examples 9-11, wherein the distal capsule portion further comprises a straight edge along a proximal edge of the distal capsule portion, and wherein moving the distal portion of the capsule deploys the anterior anchoring tab and posterior anchoring tab simultaneously.
  • Example 13 is the method of any of Examples 9-12, wherein the distal capsule portion further comprises an elongate shaft, wherein the elongate shaft has a longitudinal axis, and wherein a proximal edge of the distal capsule portion is transverse to the longitudinal axis, wherein moving the distal portion of the capsule deploys the anterior anchoring tab before the posterior anchoring tab, or wherein moving the distal potion of the capsule deploys the posterior anchoring tab before the anterior anchoring tab.
  • Example 14 is the method of any of Examples 9-13, wherein the distal capsule portion further comprises an undulating or corrugated edge along a proximal edge of the distal capsule portion, wherein moving the distal portion of the capsule deploys the anterior anchoring tab before the ventricular skirt and the posterior anchoring tab, or wherein moving the distal portion of the capsule deploys the posterior anchoring tab before the ventricular skirt and the anterior anchoring tab.
  • Example 15 is the method of any of Examples 9-14, wherein the distal portion of the delivery system further comprises a slot, wherein the slot is axially oriented, and wherein actuating the distal portion of the delivery system disposes a portion of the ventricular portion into the slot thereby removing a constraint therefrom and allowing radial expansion thereof.
  • Example 16 is the method of any of Examples 9-15, wherein the anterior anchoring tab and posterior anchoring tab each comprise at least one elbow, wherein the prosthetic valve further comprises at least one commissure tab, and wherein the distal portion of the delivery system further comprises a capsule and an elongate shaft, the capsule comprising a distal capsule portion and a proximal capsule portion and, the elongate shaft comprising a commissure control element and an elbow control element, wherein the commissure control element and elbow control element are disposed inside the capsule, wherein the at least one elbow is coupled to the elbow control element, and the at least one commissure tab is coupled to the commissure control element, and wherein actuating the distal portion of the delivery system comprises moving the proximal portion of the capsule away from the distal portion of the capsule, thereby unconstraining the commissure control element and the elbow control element.
  • Example 17 is the method of any of Examples 9-16, wherein actuating the distal portion of the delivery system comprises deploying the at least one commissure tab, wherein separating the commissure tab from the commissure control element allows radial expansion thereof.
  • Example 18 is the method of any of Examples 9-17, wherein actuating the distal portion of the delivery system comprises releasing the at least one elbow from the elbow control element and releasing the at least one commissure tab from the commissure control element simultaneously.
  • Example 19 is the method of any of Examples 9-18, wherein actuating the distal portion of the delivery system comprises releasing the at least one elbow from the elbow control element before releasing the at least one commissure tab from the commissure control element, or releasing the at least one commissure tab from the commissure control element before releasing the at least one elbow from the elbow control element.
  • Example 20 is the method of any of Examples 9-19, wherein the commissure control element further comprises slots, or wherein the elbow control element further comprises slots, and wherein the distal portion of the ventricular portion comprises protrusions disposed in the slots, wherein actuating the distal portion of the delivery system comprises separating the protrusions from the commissure control element or the elbow control element, and wherein the separation allows the ventricular portion to expand.
  • Example 21 is a system for delivering a prosthetic valve to a native mitral valve of patient’s heart, the native mitral valve having a native anterior leaflet and a native posterior leaflet, the system comprising: a prosthetic valve comprising a ventricular portion and an atrial portion, wherein the ventricular portion comprises a ventricular skirt, an anterior anchoring tab disposed on the ventricular skirt, a posterior anchoring tab disposed on the ventricular skirt, and wherein the atrial portion comprises an atrial flange; and a delivery system wherein the prosthetic valve is coupled to a distal portion of the delivery system, wherein actuation of the distal portion of the delivery system unconstrains the prosthetic valve, to allow radial expansion of the ventricular portion first, and radial expansion of the atrial portion after the ventricular portion.
  • Example 22 is the system of Example 21, wherein the distal portion of the delivery system further comprises a capsule comprising a distal capsule portion and a proximal capsule portion, and wherein actuation of the distal portion of the delivery system is configured to move the proximal capsule portion away from the distal capsule portion.
  • Example 23 is the system of any of Examples 21-22, wherein the delivery system further comprises an elongate shaft coupled to the distal capsule portion, and wherein the distal movement of the elongate shaft moves the distal capsule portion relative to the proximal capsule portion, and wherein the distal movement of the distal capsule portion is configured to unconstrain the ventricular portion.
  • Example 24 is the system of any of Examples 21-23, wherein the distal capsule portion further comprises a straight edge along a proximal edge of the distal capsule portion, wherein movement of the distal portion of the capsule is configured to deploy the anterior anchoring tab and posterior anchoring tab simultaneously.
  • Example 25 is the system of any of Examples 21-24, wherein the distal portion of the capsule further comprises an elongate shaft, wherein the elongate shaft has a longitudinal axis, wherein movement of the distal portion of the capsule is configured to deploy the anterior anchoring tab before the posterior anchoring tab, or wherein the movement of the distal portion of the capsule is configured to deploy the posterior anchoring tab before the anterior anchoring tab.
  • Example 26 is the system of any of Examples 21-25, wherein the distal capsule portion further comprises an undulating or corrugated edge along the proximal edge of the distal capsule portion, wherein the movement of the distal portion of the capsule is configured to deploy the anterior anchoring tab before the ventricular skirt and the posterior anchoring tab, or wherein the movement of the distal capsule portion is configured to deploy the posterior anchoring tab before the ventricular skirt and the posterior anchoring tab.
  • Example 27 is the system of any of Examples 21-26, wherein the distal portion of the delivery system further comprises a slot, wherein the slot is axially oriented, and wherein the actuation of the distal portion of the delivery system is configured to dispose a portion of the ventricular portion into the slot thereby removing a constraint therefrom and allowing radial expansion thereof.
  • Example 28 is the system of any of Examples 21-27, wherein the anterior anchoring tab and posterior anchoring tab each comprise at least one elbow, wherein the prosthetic valve further comprises at least one commissure tab, the distal portion of the delivery system further comprises a capsule and an elongate shaft, the capsule comprising a distal portion and a proximal portion and, the elongate shaft comprising a commissure control element and an elbow control element, wherein the commissure control element and elbow control element are disposed inside the capsule, wherein the at least one elbow is coupled to the elbow control element, and the at least one commissure tab is coupled to the commissure control element, and wherein actuation of the distal portion of the delivery system is configured to separate the proximal portion of the capsule away from the distal portion of the capsule, thereby removing a constraint therefrom.
  • Example 29 is the system of any of Examples 21-28, wherein the actuation of the distal portion of the delivery system is configured to deploy the at least one commissure tab and separate the at least one commissure tab from the commissure control element, and wherein the separation is configured to allow the distal portion of the delivery system to expand.
  • Example 30 is the system of any of Examples 21-29, wherein actuation of the distal portion of the delivery system is configured to deploy the at least one elbow from the elbow control element and wherein the deployment of the at least one commissure tab from the commissure control element occurs simultaneously.
  • Example 31 is the system of any of Examples 21-30, wherein actuation of the distal portion of the delivery system is configured to deploy the at least one elbow from the elbow control element before the deployment of the at least one commissure tab from the commissure control element, or wherein the deployment of the at least one commissure tab from the commissure control element occurs before the deployment of the at least one elbow from the elbow control element.
  • Example 32 is the system of any of Examples 21-31, wherein the commissure control element further comprises slots, or wherein the elbow control element further comprises slots, and wherein the distal portion of the ventricular portion comprises protrusions disposed in the slots, wherein actuation of the distal portion of the delivery system is configured to separate the protrusions from the commissure control element or the elbow control element, and wherein the separation is configured to allow the ventricular portion to expand.
  • the apparatuses or method of any one or any combination of Examples 1 - 32 can optionally be configured such that all elements or options recited are available to use or select from.
  • the terms“a” or“an” are used, as is common in patent documents, to include one or more than one, independent of any other instances or usages of“at least one” or“one or more.”
  • the term“or” is used to refer to a nonexclusive or, such that“A or B” includes“A but not B,”“B but not A,” and“A and B,” unless otherwise indicated.

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  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Prostheses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
PCT/CA2019/051598 2018-11-08 2019-11-08 Ventricular deployment of a transcatheter mitral valve prosthesis Ceased WO2020093172A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2021524365A JP7260930B2 (ja) 2018-11-08 2019-11-08 経カテーテル僧帽弁人工補綴物の心室展開
EP19883080.4A EP3876870B1 (en) 2018-11-08 2019-11-08 Ventricular deployment of a transcatheter mitral valve prosthesis
AU2019374743A AU2019374743B2 (en) 2018-11-08 2019-11-08 Ventricular deployment of a transcatheter mitral valve prosthesis
CA3118599A CA3118599C (en) 2018-11-08 2019-11-08 VENTRICULAR DEPLOYMENT OF A TRANSCATHETER MITRAL VALVE PROSTHESIS
CN201980088422.XA CN113271890B (zh) 2018-11-08 2019-11-08 经导管二尖瓣假体的心室展开
AU2022203596A AU2022203596B2 (en) 2018-11-08 2022-05-27 Ventricular deployment of a transcatheter mitral valve prosthesis
JP2023057807A JP7507281B2 (ja) 2018-11-08 2023-03-31 経カテーテル僧帽弁人工補綴物の心室展開

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US62/757,462 2018-11-08

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AU (2) AU2019374743B2 (https=)
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11419720B2 (en) 2010-05-05 2022-08-23 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US11737872B2 (en) 2018-11-08 2023-08-29 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
US12611303B2 (en) 2022-07-21 2026-04-28 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140277427A1 (en) * 2013-03-14 2014-09-18 Cardiaq Valve Technologies, Inc. Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
WO2023062551A1 (en) 2021-10-12 2023-04-20 Laguna Tech Usa, Inc. Prosthesis heart valve device, delivery system, interventional system and relate method
CN113796936A (zh) * 2021-10-26 2021-12-17 广东脉搏医疗科技有限公司 心房分流器植入装置及植入方法
US20230149164A1 (en) * 2021-11-17 2023-05-18 Neovasc Tiara Inc. Systems and methods for deploying and retrieving a prosthesis

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6629534B1 (en) 1999-04-09 2003-10-07 Evalve, Inc. Methods and apparatus for cardiac valve repair
US20060241745A1 (en) 2005-04-21 2006-10-26 Solem Jan O Blood flow controlling apparatus
US20070016286A1 (en) 2003-07-21 2007-01-18 Herrmann Howard C Percutaneous heart valve
WO2008103722A2 (en) 2007-02-23 2008-08-28 Endovalve, Inc. Mitral valve system
WO2009134701A2 (en) 2008-05-01 2009-11-05 Edwards Lifesciences Corporation Device and method for replacing mitral valve
US20110015731A1 (en) 2004-01-23 2011-01-20 Edwards Lifesciences Corporation Anatomically Approximate Prosthetic Mitral Valve
WO2011137531A1 (en) 2010-05-05 2011-11-10 Neovasc Inc. Transcatheter mitral valve prosthesis
US20130075215A1 (en) 2011-09-28 2013-03-28 Mitutoyo Corporation Constant-force device and micrometer
WO2013075215A1 (en) * 2011-11-23 2013-05-30 Neovasc Inc. Sequentially deployed transcatheter mitral valve prosthesis
US20130231735A1 (en) 2012-03-01 2013-09-05 Foundry Newco Xii, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US9125738B2 (en) 2011-01-11 2015-09-08 Hans Reiner Figulla Prosthetic valve for replacing an atrioventricular heart valve
WO2015188066A1 (en) 2014-06-06 2015-12-10 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US20170165064A1 (en) * 2015-12-15 2017-06-15 Neovasc Tiara Inc. Transseptal delivery system
US20180116790A1 (en) 2016-11-02 2018-05-03 Edwards Lifesciences Corporation Supra and sub-annular mitral valve delivery system

Family Cites Families (1668)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB243370A (en) 1924-11-20 1926-08-26 Charles Choffel Improvements in or relating to carburettors for internal combustion engines
FR1171437A (fr) 1958-01-27 1959-01-26 Eastman Kodak Co Procédé de fabrication de polyoléfines, produits obtenus et catalyseurs pour la mise en oeuvre de ce procédé
US6203542B1 (en) 1995-06-07 2001-03-20 Arthrocare Corporation Method for electrosurgical treatment of submucosal tissue
US6149620A (en) 1995-11-22 2000-11-21 Arthrocare Corporation System and methods for electrosurgical tissue treatment in the presence of electrically conductive fluid
US6231608B1 (en) 1995-06-07 2001-05-15 Crosscart, Inc. Aldehyde and glycosidase-treated soft and bone tissue xenografts
US6837887B2 (en) 1995-06-07 2005-01-04 Arthrocare Corporation Articulated electrosurgical probe and methods
SE510577C2 (sv) 1996-05-08 1999-06-07 Carag Ag Anordning vid implantat
US6315791B1 (en) 1996-12-03 2001-11-13 Atrium Medical Corporation Self-expanding prothesis
US6045497A (en) 1997-01-02 2000-04-04 Myocor, Inc. Heart wall tension reduction apparatus and method
US6183411B1 (en) 1998-09-21 2001-02-06 Myocor, Inc. External stress reduction device and method
US6395024B1 (en) 1997-05-20 2002-05-28 Triflo Medical, Inc. Mechanical heart valve
US6613278B1 (en) 1998-11-13 2003-09-02 Regeneration Technologies, Inc. Tissue pooling process
US6530952B2 (en) 1997-12-29 2003-03-11 The Cleveland Clinic Foundation Bioprosthetic cardiovascular valve system
US7208011B2 (en) 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US7658727B1 (en) 1998-04-20 2010-02-09 Medtronic, Inc Implantable medical device with enhanced biocompatibility and biostability
US6221104B1 (en) 1998-05-01 2001-04-24 Cor Restore, Inc. Anterior and interior segment cardiac restoration apparatus and method
US6250308B1 (en) 1998-06-16 2001-06-26 Cardiac Concepts, Inc. Mitral valve annuloplasty ring and method of implanting
CA2337164A1 (en) 1998-07-13 2000-01-20 Acorn Cardiovascular, Inc. Cardiac disease treatment device and method
US7569062B1 (en) 1998-07-15 2009-08-04 St. Jude Medical, Inc. Mitral and tricuspid valve repair
EP2111800B1 (en) 1998-07-29 2016-06-15 Edwards Lifesciences AG Transventricular implant tools and devices
US6260552B1 (en) 1998-07-29 2001-07-17 Myocor, Inc. Transventricular implant tools and devices
US6406488B1 (en) 1998-08-27 2002-06-18 Heartstent Corporation Healing transmyocardial implant
US7118600B2 (en) 1998-08-31 2006-10-10 Wilson-Cook Medical, Inc. Prosthesis having a sleeve valve
US6641610B2 (en) 1998-09-10 2003-11-04 Percardia, Inc. Valve designs for left ventricular conduits
ATE322230T1 (de) 1998-09-10 2006-04-15 Percardia Inc Tmr vorrichtung
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
US6200341B1 (en) 1998-09-25 2001-03-13 Sulzer Carbomedics Inc. Mechanical heart valve assembly with super-elastic lock wire
US6432126B1 (en) 1998-09-30 2002-08-13 C.R. Bard, Inc. Flexible vascular inducing implants
US6458092B1 (en) 1998-09-30 2002-10-01 C. R. Bard, Inc. Vascular inducing implants
US6248112B1 (en) 1998-09-30 2001-06-19 C. R. Bard, Inc. Implant delivery system
ES2234311T3 (es) 1998-09-30 2005-06-16 Medtronic, Inc. Procedimiento que permite reducir la mineralizacion de un tejido utilizado para un transplante.
US6475239B1 (en) 1998-10-13 2002-11-05 Sulzer Carbomedics Inc. Method for making polymer heart valves with leaflets having uncut free edges
US6102945A (en) 1998-10-16 2000-08-15 Sulzer Carbomedics, Inc. Separable annuloplasty ring
ATE328618T1 (de) 1998-10-28 2006-06-15 Cellon S A Strukturierter und poröser silikonkautschuk
BE1012536A3 (fr) 1998-11-04 2000-12-05 Baxter Int Element muni d'une couche de fibrine sa preparation et son utilisation.
US6001056A (en) 1998-11-13 1999-12-14 Baxter International Inc. Smooth ventricular assist device conduit
US6540780B1 (en) 1998-11-23 2003-04-01 Medtronic, Inc. Porous synthetic vascular grafts with oriented ingrowth channels
US6692520B1 (en) 1998-12-15 2004-02-17 C. R. Bard, Inc. Systems and methods for imbedded intramuscular implants
WO2000038595A1 (fr) 1998-12-28 2000-07-06 Alexandr Vasilievich Samkov Prothese de valvule du coeur
WO2000042950A2 (en) 1999-01-26 2000-07-27 Edwards Lifesciences Corporation Flexible heart valve
US6383147B1 (en) 1999-01-26 2002-05-07 Edwards Lifesciences Corporation Anatomical orifice sizers and methods of orifice sizing
CA2361670C (en) 1999-01-27 2010-03-30 Viacor Incorporated Cardiac valve procedure methods and devices
DE19904975A1 (de) 1999-02-06 2000-09-14 Impella Cardiotech Ag Vorrichtung zur intravasalen Herzklappenoperation
US20030068815A1 (en) 1999-02-11 2003-04-10 Stone Kevin R. Sterilized xenograft tissue
NO308575B1 (no) 1999-02-17 2000-10-02 Sumit Roy Flerbruksventil
DE19910233A1 (de) 1999-03-09 2000-09-21 Jostra Medizintechnik Ag Anuloplastieprothese
US20040044350A1 (en) 1999-04-09 2004-03-04 Evalve, Inc. Steerable access sheath and methods of use
US7666204B2 (en) 1999-04-09 2010-02-23 Evalve, Inc. Multi-catheter steerable guiding system and methods of use
US8216256B2 (en) 1999-04-09 2012-07-10 Evalve, Inc. Detachment mechanism for implantable fixation devices
US6752813B2 (en) 1999-04-09 2004-06-22 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US6231602B1 (en) 1999-04-16 2001-05-15 Edwards Lifesciences Corporation Aortic annuloplasty ring
EP1584307A3 (en) 1999-04-23 2005-10-19 St.Jude Medical ATG, Inc. Artificial heart valve with attachment fingers
US6620170B1 (en) 1999-04-26 2003-09-16 C. R. Bard, Inc. Devices and methods for treating ischemia by creating a fibrin plug
DE60035495T2 (de) 1999-04-28 2008-03-20 St. Jude Medical, Inc., St. Paul Aortenherzklappenprothesenmess- und -markierungsvorrichtung
DE19919625C2 (de) 1999-04-29 2002-10-31 Symetis Ag Zuerich In-vitro-Verfahren zum Herstellen einer homologen Herzklappe und durch dieses Verfahren herstellbare Klappe
DE60029404T2 (de) 1999-05-14 2007-02-22 C.R. Bard, Inc. Wirkstoffabgabesysteme
US6790229B1 (en) 1999-05-25 2004-09-14 Eric Berreklouw Fixing device, in particular for fixing to vascular wall tissue
SE514718C2 (sv) 1999-06-29 2001-04-09 Jan Otto Solem Anordning för behandling av bristande tillslutningsförmåga hos mitralisklaffapparaten
US7192442B2 (en) 1999-06-30 2007-03-20 Edwards Lifesciences Ag Method and device for treatment of mitral insufficiency
US6610071B1 (en) 1999-07-26 2003-08-26 Beth Israel Deaconess Medical Center Suture system
ATE258768T1 (de) 1999-08-05 2004-02-15 Broncus Tech Inc Verfahren und vorrichtungen zur herstellung von kollateralen kanälen in den lungen
US7022088B2 (en) 1999-08-05 2006-04-04 Broncus Technologies, Inc. Devices for applying energy to tissue
US6293951B1 (en) 1999-08-24 2001-09-25 Spiration, Inc. Lung reduction device, system, and method
US6350281B1 (en) 1999-09-14 2002-02-26 Edwards Lifesciences Corp. Methods and apparatus for measuring valve annuluses during heart valve-replacement surgery
CN1236733C (zh) 1999-09-20 2006-01-18 Ev3阳光谷股份有限公司 一种用来关闭身体孔洞的闭合导管
AU5843099A (en) 1999-09-22 2001-04-24 Baxter International Inc. Cardiac valve and method for preparing a biological tissue
US6358278B1 (en) 1999-09-24 2002-03-19 St. Jude Medical, Inc. Heart valve prosthesis with rotatable cuff
IT1307268B1 (it) 1999-09-30 2001-10-30 Sorin Biomedica Cardio Spa Dispositivo per interventi di riparazione o sostituzione valvolarecardiaca.
US6371983B1 (en) 1999-10-04 2002-04-16 Ernest Lane Bioprosthetic heart valve
US6416547B1 (en) 1999-10-06 2002-07-09 Edwards Lifesciences Corporation Heart valve carrier and rinse cage
FR2799364B1 (fr) 1999-10-12 2001-11-23 Jacques Seguin Dispositif d'annuloplastie utilisable par voie mini-invasive
CA2286929A1 (en) 1999-10-18 2001-04-18 Anthony Paolitto Valve surgery apparatus
US6440164B1 (en) 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
JP2001120582A (ja) 1999-10-22 2001-05-08 Gunze Ltd 人工心臓弁およびその作製方法
FR2815844B1 (fr) 2000-10-31 2003-01-17 Jacques Seguin Support tubulaire de mise en place, par voie percutanee, d'une valve cardiaque de remplacement
FR2800984B1 (fr) 1999-11-17 2001-12-14 Jacques Seguin Dispositif de remplacement d'une valve cardiaque par voie percutanee
US20070043435A1 (en) 1999-11-17 2007-02-22 Jacques Seguin Non-cylindrical prosthetic valve system for transluminal delivery
US7195641B2 (en) 1999-11-19 2007-03-27 Advanced Bio Prosthetic Surfaces, Ltd. Valvular prostheses having metal or pseudometallic construction and methods of manufacture
US6458153B1 (en) 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
GB0114345D0 (en) 2001-06-13 2001-08-08 Aortech Europ Ltd Heart valve prosthesis and method of manufacture
GB9928905D0 (en) 1999-12-08 2000-02-02 Aortech Europ Ltd Prosthesis
US7632309B1 (en) 1999-12-13 2009-12-15 St. Jude Medical, Inc. Pyrolytic carbon and metal/metalloid carbide composites
SE514886C2 (sv) 1999-12-14 2001-05-14 Jcl Technic Ab Kärlventil, såsom hjärtklaff,samt förfarande för dess framställning
AU2435801A (en) 1999-12-23 2001-07-09 Edwards Lifesciences Corporation Enhanced visualization of medical implants
NL1014095C2 (nl) 2000-01-17 2001-07-18 Cornelis Hendrikus Anna Witten Implantaatklep voor implantatie in een bloedvat.
DE60138683D1 (de) 2000-01-25 2009-06-25 Edwards Lifesciences Corp Bioaktive beschichtungen zur vermeidung von gewebewachstum auf künstlichen herzklappen
HUP0204398A2 (en) 2000-01-27 2003-03-28 3F Therapeutics Prosthetic heart valve
MXPA02007426A (es) 2000-01-31 2003-10-14 Cook Biotech Inc Valvulas restringidas y uso de las mismas.
US6402781B1 (en) 2000-01-31 2002-06-11 Mitralife Percutaneous mitral annuloplasty and cardiac reinforcement
US7507252B2 (en) 2000-01-31 2009-03-24 Edwards Lifesciences Ag Adjustable transluminal annuloplasty system
EP1900343B1 (en) 2000-01-31 2015-10-21 Cook Biotech Incorporated Stent valves
EP1251803B1 (en) 2000-02-02 2005-06-01 Robert V. Snyders Artificial heart valve
KR100786028B1 (ko) 2000-02-03 2007-12-17 쿡 인코포레이티드 이식가능한 혈관장치
DE10010073B4 (de) 2000-02-28 2005-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verankerung für implantierbare Herzklappenprothesen
DE10010074B4 (de) 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Befestigung und Verankerung von Herzklappenprothesen
US6378221B1 (en) 2000-02-29 2002-04-30 Edwards Lifesciences Corporation Systems and methods for mapping and marking the thickness of bioprosthetic sheet
WO2001066043A1 (en) 2000-03-03 2001-09-13 Thorpe Patricia E Bulbous valve and stent for treating vascular reflux
US6679264B1 (en) 2000-03-04 2004-01-20 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
ATE346563T1 (de) 2000-03-10 2006-12-15 Paracor Medical Inc Expandierbarer herzbeutel zur behandlung von kongestiven herzversagens
ATE362382T1 (de) 2000-03-15 2007-06-15 Orbusneich Medical Inc Beschichtung welche ein anhaften von endothelzellen stimuliert
US6537198B1 (en) 2000-03-21 2003-03-25 Myocor, Inc. Splint assembly for improving cardiac function in hearts, and method for implanting the splint assembly
US6953476B1 (en) 2000-03-27 2005-10-11 Neovasc Medical Ltd. Device and method for treating ischemic heart disease
US6478776B1 (en) 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
ITPC20000013A1 (it) 2000-04-13 2000-07-13 Paolo Ferrazzi Dispositivo endoventricolare e metodo relativo per il trattamento e la correzione di miocardiopatie.
WO2001080782A1 (de) 2000-04-27 2001-11-01 Axel Haverich Individuelle venenklappenprothese
US8632583B2 (en) 2011-05-09 2014-01-21 Palmaz Scientific, Inc. Implantable medical device having enhanced endothelial migration features and methods of making the same
US8252044B1 (en) 2000-11-17 2012-08-28 Advanced Bio Prosthestic Surfaces, Ltd. Device for in vivo delivery of bioactive agents and method of manufacture thereof
US6419695B1 (en) 2000-05-22 2002-07-16 Shlomo Gabbay Cardiac prosthesis for helping improve operation of a heart valve
NZ522752A (en) 2000-05-25 2004-08-27 Bioring S Device for shrinking or reinforcing the heart valvular orifices
US6902522B1 (en) 2000-06-12 2005-06-07 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
EP1330189B1 (en) 2000-06-23 2007-12-19 Viacor Incorporated Automated annular plication for mitral valve repair
EP1512383B1 (en) 2000-06-26 2013-02-20 Rex Medical, L.P. A vascular system for valve leaflet apposition
US6695878B2 (en) 2000-06-26 2004-02-24 Rex Medical, L.P. Vascular device for valve leaflet apposition
WO2002001999A2 (en) 2000-06-30 2002-01-10 Viacor, Incorporated Method and apparatus for performing a procedure on a cardiac valve
US6419696B1 (en) 2000-07-06 2002-07-16 Paul A. Spence Annuloplasty devices and related heart valve repair methods
US7077861B2 (en) 2000-07-06 2006-07-18 Medtentia Ab Annuloplasty instrument
US7323010B2 (en) 2000-07-11 2008-01-29 Alessandro Verona Biomaterial including animal corneal tissue
DE10033858B4 (de) 2000-07-12 2006-01-26 Max Hauser Süddeutsche Chirurgiemechanik GmbH Vorrichtung zum Spreizen von Gewebe, Gewebeteilen, Organen, Knochen oder anderen Körperteilen bei chirurgischen Eingriffen in menschlichen oder tierischen Körpern
JP4911742B2 (ja) 2000-07-12 2012-04-04 エドワーズ ライフサイエンシーズ コーポレイション 心臓弁ワイヤフォームを形成するための方法および装置
US6409758B2 (en) 2000-07-27 2002-06-25 Edwards Lifesciences Corporation Heart valve holder for constricting the valve commissures and methods of use
US7862500B2 (en) 2002-08-01 2011-01-04 Cardiokinetix, Inc. Multiple partitioning devices for heart treatment
US7399271B2 (en) 2004-01-09 2008-07-15 Cardiokinetix, Inc. Ventricular partitioning device
EP1179353A1 (de) 2000-08-11 2002-02-13 B. Braun Melsungen Ag Antithrombogene Implantate mit Beschichtung aus Polyphosphazenen und einem pharmakologisch aktiven Wirkstoff
MXPA03001406A (es) 2000-08-15 2004-05-04 Surmodics Inc Matriz de incorporacion de medicamento.
US6572652B2 (en) 2000-08-29 2003-06-03 Venpro Corporation Method and devices for decreasing elevated pulmonary venous pressure
US6458155B1 (en) 2000-09-01 2002-10-01 Edwards Lifesciences Corporation Fresh donor heart valve sizer and method of use
DE10046550A1 (de) 2000-09-19 2002-03-28 Adiam Life Science Ag Prothetische Mitral-Herzklappe
US8956407B2 (en) 2000-09-20 2015-02-17 Mvrx, Inc. Methods for reshaping a heart valve annulus using a tensioning implant
US8784482B2 (en) 2000-09-20 2014-07-22 Mvrx, Inc. Method of reshaping a heart valve annulus using an intravascular device
ATE346571T1 (de) 2000-09-21 2006-12-15 St Jude Medical Ventilprothesen mit blattelementen aus verstärktem kunststoff
US6461382B1 (en) 2000-09-22 2002-10-08 Edwards Lifesciences Corporation Flexible heart valve having moveable commissures
EP1193213A1 (en) 2000-09-28 2002-04-03 Le Creuset S.A. Cutting device
US6602288B1 (en) 2000-10-05 2003-08-05 Edwards Lifesciences Corporation Minimally-invasive annuloplasty repair segment delivery template, system and method of use
US6616684B1 (en) 2000-10-06 2003-09-09 Myocor, Inc. Endovascular splinting devices and methods
US6602286B1 (en) 2000-10-26 2003-08-05 Ernst Peter Strecker Implantable valve system
WO2002035992A2 (en) 2000-10-30 2002-05-10 Children's Medical Center Corporation Tissue-engineered vascular structures
CA2396170A1 (en) 2000-11-08 2002-05-16 Julie K. Buffenbarger Self-indicating neutralizing compositions
EP1337188B1 (en) 2000-11-16 2012-03-07 Donald J. Hill Automatic suture fixation apparatus and method
US6953332B1 (en) 2000-11-28 2005-10-11 St. Jude Medical, Inc. Mandrel for use in forming valved prostheses having polymer leaflets by dip coating
DE10060660A1 (de) 2000-12-06 2002-06-20 Frey Rainer Verfahren zur Konservierung von biologischen Prothesen, konservierte biologische Prothese und Konservierungslösung
ATE310470T1 (de) 2000-12-15 2005-12-15 Angiomed Ag Stent mit herzklappe
DE10064948C1 (de) 2000-12-20 2002-07-11 Auto Tissue Gmbh Verfahren zur Dezellularisierung von Fremdmaterial zur Herstellung von Bioprothesen und Vorrichtung zur Durchführung des Verfahrens
US6964682B2 (en) 2000-12-21 2005-11-15 Edwards Lifesciences Corporation Heart valve holder that resist suture looping
US7591826B2 (en) 2000-12-28 2009-09-22 Cardiac Dimensions, Inc. Device implantable in the coronary sinus to provide mitral valve therapy
DE10065824B4 (de) 2000-12-28 2018-10-31 Jotec Gmbh Endovaskulärer Stent zur Implantation in den aufsteigenden Ast der Aorta
CA2433881C (en) 2001-01-30 2009-08-18 Edwards Lifesciences Ag Medical system and method for remodeling an extravascular tissue structure
US6955689B2 (en) 2001-03-15 2005-10-18 Medtronic, Inc. Annuloplasty band and method
US6503272B2 (en) 2001-03-21 2003-01-07 Cordis Corporation Stent-based venous valves
EP1245202B1 (en) 2001-03-27 2004-08-04 William Cook Europe ApS An aortic graft device
WO2002078576A2 (en) 2001-03-29 2002-10-10 Viacor, Inc. Method and apparatus for improving mitral valve function
WO2002087481A1 (en) 2001-04-27 2002-11-07 Myomend, Inc. Prevention of myocardial infarction induced ventricular expansion and remodeling
CA2446064A1 (en) 2001-05-02 2002-11-07 Nitromed, Inc. Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use
US6676702B2 (en) 2001-05-14 2004-01-13 Cardiac Dimensions, Inc. Mitral valve therapy assembly and method
US6800090B2 (en) 2001-05-14 2004-10-05 Cardiac Dimensions, Inc. Mitral valve therapy device, system and method
US6858039B2 (en) 2002-07-08 2005-02-22 Edwards Lifesciences Corporation Mitral valve annuloplasty ring having a posterior bow
ITMI20011012A1 (it) 2001-05-17 2002-11-17 Ottavio Alfieri Protesi anulare per valvola mitrale
DE60224800D1 (de) 2001-05-24 2008-03-13 Chase Medical Lp Apparat und set zur verwendung bei der wiederherstellung des ventrikels
GB0113121D0 (en) 2001-05-30 2001-07-18 Univ Leeds Biologically active photosensitisers
JP4078298B2 (ja) 2001-06-08 2008-04-23 レックス メディカル リミテッド パートナーシップ 血管壁に近接する弁を備えた血管器具
ATE278367T1 (de) 2001-06-11 2004-10-15 Sorin Biomedica Cardio Spa Annuloplastieprothese und herstellungsverfahren dafür
NL1018302C1 (nl) 2001-06-15 2002-07-17 Eric Berreklouw Applicator voor een prothese, samenstel omvattende een dergelijke applicator alsmede spanstelsel voor het laden van een dergelijke applicator.
FR2826863B1 (fr) 2001-07-04 2003-09-26 Jacques Seguin Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
ES2321590T3 (es) 2001-07-26 2009-06-09 3F Therapeutics, Inc Metodo de corte de material para utilizar en un dispositivo medico implantable.
FR2828091B1 (fr) 2001-07-31 2003-11-21 Seguin Jacques Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
FR2828263B1 (fr) 2001-08-03 2007-05-11 Philipp Bonhoeffer Dispositif d'implantation d'un implant et procede d'implantation du dispositif
US20040249443A1 (en) 2001-08-20 2004-12-09 Shanley John F. Expandable medical device for treating cardiac arrhythmias
US20030083210A1 (en) 2001-08-24 2003-05-01 Unilever Home And Personal Care Usa, Division Of Conopco, Inc. Lamellar post foaming cleansing composition and dispensing system
US6675809B2 (en) 2001-08-27 2004-01-13 Richard S. Stack Satiation devices and methods
US6845776B2 (en) 2001-08-27 2005-01-25 Richard S. Stack Satiation devices and methods
US6908482B2 (en) 2001-08-28 2005-06-21 Edwards Lifesciences Corporation Three-dimensional annuloplasty ring and template
EP1423066B1 (en) 2001-09-07 2008-07-16 Mardil, Inc. Method and apparatus for external heart stabilization
US6562069B2 (en) 2001-09-19 2003-05-13 St. Jude Medical, Inc. Polymer leaflet designs for medical devices
US7060023B2 (en) 2001-09-25 2006-06-13 The Foundry Inc. Pericardium reinforcing devices and methods of using them
US6695769B2 (en) 2001-09-25 2004-02-24 The Foundry, Inc. Passive ventricular support devices and methods of using them
EP1429690B1 (en) 2001-09-26 2006-11-29 Edwards Lifesciences Corporation Low-profile heart valve sewing ring
US6790237B2 (en) 2001-10-09 2004-09-14 Scimed Life Systems, Inc. Medical stent with a valve and related methods of manufacturing
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
AU2002347900B8 (en) 2001-10-11 2006-01-12 Emphasys Medical, Inc. Bronchial flow control devices and methods of use
US6893431B2 (en) 2001-10-15 2005-05-17 Scimed Life Systems, Inc. Medical device for delivering patches
US6923936B2 (en) 2001-10-23 2005-08-02 Medtronic Minimed, Inc. Sterile device and method for producing same
EP1478364B1 (en) 2001-11-07 2009-09-16 Quonova, LLC Selective antibacterial agents
US6805710B2 (en) 2001-11-13 2004-10-19 Edwards Lifesciences Corporation Mitral valve annuloplasty ring for molding left ventricle geometry
US20050177180A1 (en) 2001-11-28 2005-08-11 Aptus Endosystems, Inc. Devices, systems, and methods for supporting tissue and/or structures within a hollow body organ
CA2466270C (en) 2001-11-29 2010-09-14 Cook Incorporated Medical device delivery system
US6976995B2 (en) 2002-01-30 2005-12-20 Cardiac Dimensions, Inc. Fixed length anchor and pull mitral valve device and method
US6908478B2 (en) 2001-12-05 2005-06-21 Cardiac Dimensions, Inc. Anchor and pull mitral valve device and method
WO2003053289A1 (en) 2001-12-21 2003-07-03 Simcha Milo Implantation system for annuloplasty rings
EP2181668A1 (en) 2001-12-28 2010-05-05 Edwards Lifesciences AG Device for treating mitral annulus dilatation comprising a balloon catheter and a stent
US7189258B2 (en) 2002-01-02 2007-03-13 Medtronic, Inc. Heart valve system
WO2003105670A2 (en) 2002-01-10 2003-12-24 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US6756449B2 (en) 2002-02-27 2004-06-29 Medtronic, Inc. AnB block copolymers containing poly (vinyl pyrrolidone) units, medical devices, and methods
US7048754B2 (en) 2002-03-01 2006-05-23 Evalve, Inc. Suture fasteners and methods of use
US6797001B2 (en) 2002-03-11 2004-09-28 Cardiac Dimensions, Inc. Device, assembly and method for mitral valve repair
ITPD20020064A1 (it) 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
US6719786B2 (en) 2002-03-18 2004-04-13 Medtronic, Inc. Flexible annuloplasty prosthesis and holder
EP2153799B1 (en) 2002-03-27 2011-08-03 Sorin Biomedica Cardio S.r.l. A prosthesis for annuloplasty comprising a perforated element
NL1020288C1 (nl) 2002-04-02 2003-05-07 Eric Berreklouw Samenstel omvattende een stabilisator en een in of rondom een door lichaamsweefsel, omgeven doorgang te positioneren instrument.
US6752828B2 (en) 2002-04-03 2004-06-22 Scimed Life Systems, Inc. Artificial valve
WO2003086495A1 (en) 2002-04-09 2003-10-23 Astra Tech Ab Medical prosthetic devices having improved biocompatibility
US7108685B2 (en) 2002-04-15 2006-09-19 Boston Scientific Scimed, Inc. Patch stabilization of rods for treatment of cardiac muscle
US7160320B2 (en) 2002-04-16 2007-01-09 The International Heart Institute Of Montana Foundation Reed valve for implantation into mammalian blood vessels and heart with optional temporary or permanent support
FR2838631B1 (fr) 2002-04-23 2004-12-24 Engeneering And Technological Procede de realisation d'une prothese de valve cardiaque aortique ou mitrale et prothese de valve cardiaque aortique ou mitrale ainsi obtenue
US6761735B2 (en) 2002-04-25 2004-07-13 Medtronic, Inc. Heart valve fixation process and apparatus
CA2950492C (en) 2002-05-08 2018-12-04 Cardiac Dimensions Pty. Ltd. Device and method for modifying the shape of a body organ
US7485141B2 (en) 2002-05-10 2009-02-03 Cordis Corporation Method of placing a tubular membrane on a structural frame
AU2003225291A1 (en) 2002-05-10 2003-11-11 Cordis Corporation Method of making a medical device having a thin wall tubular membrane over a structural frame
US7351256B2 (en) 2002-05-10 2008-04-01 Cordis Corporation Frame based unidirectional flow prosthetic implant
DE10221076A1 (de) 2002-05-11 2003-11-27 Ruesch Willy Gmbh Stent
EP2075014B9 (en) 2002-05-24 2012-02-01 Angiotech International Ag Compositions and methods for coating medical implants
US7753924B2 (en) 2003-09-04 2010-07-13 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US20060122633A1 (en) 2002-06-13 2006-06-08 John To Methods and devices for termination
US7172625B2 (en) 2002-07-16 2007-02-06 Medtronic, Inc. Suturing rings for implantable heart valve prostheses
US7578843B2 (en) 2002-07-16 2009-08-25 Medtronic, Inc. Heart valve prosthesis
DE60323502D1 (de) 2002-07-26 2008-10-23 Emphasys Medical Inc Bronchiale durchflussvorrichtung mit einer membranabdichtung
DE10235237A1 (de) 2002-08-01 2004-02-12 Symetis Ag In-vitro-Verfahren zum Herstellen einer homologen "gestenteten" Tissue eingineerten Herzklappe
US8292884B2 (en) 2002-08-01 2012-10-23 Levine Robert A Cardiac devices and methods for minimally invasive repair of ischemic mitral regurgitation
DE10301026B4 (de) 2002-08-13 2014-10-30 Jenavalve Technology Inc. Vorrichtung zur Verankerung und Ausrichtung von Herzklappenprothesen
DE20321838U1 (de) 2002-08-13 2011-02-10 JenaValve Technology Inc., Wilmington Vorrichtung zur Verankerung und Ausrichtung von Herzklappenprothesen
EP1545392B1 (en) 2002-08-15 2013-10-02 Cook Medical Technologies LLC Implantable vascular device
CA2494970C (en) 2002-08-15 2009-12-29 Cook Incorporated Stent and method of forming a stent with integral barbs
CA2503258C (en) 2002-08-28 2011-08-16 Heart Leaflet Technologies, Inc. Method and device for treating diseased valve
ATE464028T1 (de) 2002-08-29 2010-04-15 St Jude Medical Cardiology Div Implantierbare vorrichtungen zur kontrolle des inneren durchmessers einer öffnung im körper
KR100442330B1 (ko) 2002-09-03 2004-07-30 주식회사 엠아이텍 스텐트 및 이 스텐트의 제조방법
DE10242154A1 (de) 2002-09-05 2004-03-18 Sievers, Hans-Heinrich, Prof.Dr. Gefäßprothese, insbesondere zum Ersatz der Aorta ascendens
US7137184B2 (en) 2002-09-20 2006-11-21 Edwards Lifesciences Corporation Continuous heart valve support frame and method of manufacture
CO5500017A1 (es) 2002-09-23 2005-03-31 3F Therapeutics Inc Valvula mitral protesica
ATE418938T1 (de) 2002-10-01 2009-01-15 Ample Medical Inc Vorrichtungen und systeme zur umformung eines herzklappen-annulus
WO2004032796A2 (en) 2002-10-10 2004-04-22 The Cleveland Clinic Foundation Method and apparatus for replacing a mitral valve with a stentless bioprosthetic valve
ATE516756T1 (de) 2002-11-12 2011-08-15 Edwards Lifesciences Ag Vorrichtungen zur behandlung der herzklappe
EP1583581A4 (en) 2002-11-13 2008-09-10 Medtronic Inc HEADLAPPING METHOD AND DEVICES
EP1581120B1 (en) 2002-11-27 2009-08-19 Carag AG An implant for occluding a passage
FR2847800B1 (fr) 2002-11-28 2005-10-14 Perouse Laboratoires Valve prothetique interchangeable
GB0229274D0 (en) 2002-12-16 2003-01-22 Anson Medical Ltd Instrument for testing pulsatile endurance of vascular implants
US8551162B2 (en) 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis
US6945957B2 (en) 2002-12-30 2005-09-20 Scimed Life Systems, Inc. Valve treatment catheter and methods
CA2513726C (en) 2003-01-27 2014-08-12 Corassist Cardiovascular Ltd. In vivo device for improving diastolic ventricular function
JP4684991B2 (ja) 2003-01-31 2011-05-18 ボストン サイエンティフィック リミテッド 薬物添加ナノカプセルを用いる局所的薬物デリバリー
GB2398245B (en) 2003-02-06 2007-03-28 Great Ormond Street Hospital F Valve prosthesis
ATE343403T1 (de) 2003-02-10 2006-11-15 Heraeus Gmbh W C Verbesserte metalllegierung für medizinische geräte und implantate
US7077801B2 (en) 2003-02-19 2006-07-18 Corlife Gbr Methods and devices for improving cardiac output
US20040254600A1 (en) 2003-02-26 2004-12-16 David Zarbatany Methods and devices for endovascular mitral valve correction from the left coronary sinus
NZ542645A (en) 2003-02-28 2008-01-31 Edward G Shifrin Extravenous corrector for repair of incompetent venous valves
WO2004078065A2 (en) 2003-03-03 2004-09-16 Sinus Rhythm Technologies, Inc. Electrical conduction block implant device
DE602004024766D1 (https=) 2003-03-12 2010-02-04 Cook Inc
US7381210B2 (en) 2003-03-14 2008-06-03 Edwards Lifesciences Corporation Mitral valve repair system and method for use
US7399315B2 (en) 2003-03-18 2008-07-15 Edwards Lifescience Corporation Minimally-invasive heart valve with cusp positioners
ES2311148T3 (es) 2003-03-20 2009-02-01 Aortech International Plc Valvula.
CH696185A5 (fr) 2003-03-21 2007-02-15 Afksendiyos Kalangos Dispositif de renfort intraparietal pour prothèse biologique et prothèse biologique renforcée.
KR100466839B1 (ko) 2003-03-28 2005-01-17 주식회사 사이언씨티 대동맥판막 성형기구 세트 및 이를 이용한 치료방법
WO2004089253A1 (en) 2003-04-01 2004-10-21 Cook Incorporated Percutaneously deployed vascular valves
EP2163224A1 (en) 2003-04-08 2010-03-17 Cook Incorporated Intraluminal support device with graft
US7530995B2 (en) 2003-04-17 2009-05-12 3F Therapeutics, Inc. Device for reduction of pressure effects of cardiac tricuspid valve regurgitation
US7159593B2 (en) 2003-04-17 2007-01-09 3F Therapeutics, Inc. Methods for reduction of pressure effects of cardiac tricuspid valve regurgitation
EP2133039B1 (en) 2003-04-24 2014-10-08 Cook Medical Technologies LLC Artificial valve prosthesis with improved flow dynamics
CA2523812C (en) 2003-04-28 2011-06-21 Medtronic, Inc. Compliant venous graft
GB0309616D0 (en) 2003-04-28 2003-06-04 Angiomed Gmbh & Co Loading and delivery of self-expanding stents
DE602004018059D1 (de) 2003-04-30 2009-01-15 Medtronic Vascular Inc Perivaskulares Reparatursystem für Leckagen
DE602004023350D1 (de) 2003-04-30 2009-11-12 Medtronic Vascular Inc Perkutaneingesetzte provisorische Klappe
AU2004238128B2 (en) 2003-05-15 2008-10-30 Coretissue Bioengineering Inc. Method of removing cell
DE10322024A1 (de) 2003-05-16 2004-12-02 Symetis Ag Bioreaktor zum Herstellen einer Gewebeprothese, insbesondere Herzklappe
JP4547381B2 (ja) 2003-05-19 2010-09-22 セプトアールエックス インコーポレイテッド 治療用組織拡張デバイスおよび関連方法
US7128759B2 (en) 2003-05-19 2006-10-31 Cook Incorporated Implantable medical device with constrained expansion
DE602004026858D1 (de) 2003-05-20 2010-06-10 Cleveland Clinic Foundation Vorrichtung zur reparatur von herzklappen
US7520947B2 (en) 2003-05-23 2009-04-21 Ati Properties, Inc. Cobalt alloys, methods of making cobalt alloys, and implants and articles of manufacture made therefrom
EP1631218B1 (en) 2003-05-28 2010-09-15 Cook Incorporated Prosthetic valve with vessel engaging member
US7445593B2 (en) 2003-06-18 2008-11-04 The Texas A&M University System Device for proactive modulation of cardiac strain patterns
US6974862B2 (en) 2003-06-20 2005-12-13 Kensey Nash Corporation High density fibrous polymers suitable for implant
RU2006103367A (ru) 2003-07-08 2006-06-27 Вентор Текнолоджиз Лтд. (Il) Имплантируемые протезные устройства, в частности, для трансартериальной доставки при лечении аортального стеноза и способы имплантации таких устройств
US7201772B2 (en) 2003-07-08 2007-04-10 Ventor Technologies, Ltd. Fluid flow prosthetic device
NZ527025A (en) 2003-07-16 2007-01-26 David Peter Shaw Prosthetic valves for medical application
IES20030531A2 (en) 2003-07-17 2005-09-21 Medtronic Vascular Connaught Methods and devices for placing a fistula device in fluid communication with a target vessel
CA2533020A1 (en) 2003-07-18 2005-03-03 Ev3 Santa Rosa, Inc. Remotely activated mitral annuloplasty system and methods
US9498366B2 (en) 2003-07-28 2016-11-22 Baronova, Inc. Devices and methods for pyloric anchoring
DE10334868B4 (de) 2003-07-29 2013-10-17 Pfm Medical Ag Implantierbare Einrichtung als Organklappenersatz, dessen Herstellungsverfahren sowie Grundkörper und Membranelement dafür
WO2005011534A1 (en) 2003-07-31 2005-02-10 Cook Incorporated Prosthetic valve devices and methods of making such devices
FR2858543B1 (fr) 2003-08-08 2006-02-03 Assist Publ Hopitaux De Paris Anneau aortique et ancillaire pour sa pose
CA2536961A1 (en) 2003-08-14 2005-02-24 Blue Medical Devices B.V. Endoluminal prosthesis comprising a therapeutic agent
US8021421B2 (en) 2003-08-22 2011-09-20 Medtronic, Inc. Prosthesis heart valve fixturing device
DE10340265A1 (de) 2003-08-29 2005-04-07 Sievers, Hans-Hinrich, Prof. Dr.med. Prothese zum Ersatz der Aorten- und/oder Mitralklappe des Herzens
US7785653B2 (en) 2003-09-22 2010-08-31 Innovational Holdings Llc Method and apparatus for loading a beneficial agent into an expandable medical device
US20050075725A1 (en) 2003-10-02 2005-04-07 Rowe Stanton J. Implantable prosthetic valve with non-laminar flow
AU2004279391A1 (en) 2003-10-03 2005-04-21 Edwards Lifesciences Corporation Annuloplasty rings for repair of abnormal mitral valves
US20060259137A1 (en) 2003-10-06 2006-11-16 Jason Artof Minimally invasive valve replacement system
CA2545874C (en) 2003-10-06 2012-02-21 3F Therapeutics, Inc. Minimally invasive valve replacement system
US7604650B2 (en) 2003-10-06 2009-10-20 3F Therapeutics, Inc. Method and assembly for distal embolic protection
US9579194B2 (en) 2003-10-06 2017-02-28 Medtronic ATS Medical, Inc. Anchoring structure with concave landing zone
US20050075720A1 (en) 2003-10-06 2005-04-07 Nguyen Tuoc Tan Minimally invasive valve replacement system
US10219899B2 (en) 2004-04-23 2019-03-05 Medtronic 3F Therapeutics, Inc. Cardiac valve replacement systems
US7842084B2 (en) 2005-06-21 2010-11-30 3F Therapeutics, Inc. Method and systems for sizing, folding, holding, and delivering a heart valve prosthesis
US7556647B2 (en) 2003-10-08 2009-07-07 Arbor Surgical Technologies, Inc. Attachment device and methods of using the same
WO2005039428A2 (en) 2003-10-17 2005-05-06 Edwards Lifesciences Ag Heart valve leaflet locator
ITBO20030631A1 (it) 2003-10-23 2005-04-24 Roberto Erminio Parravicini Apparecchiatura protesica valvolare, in particolare per applicazioni cardiache.
US7347869B2 (en) 2003-10-31 2008-03-25 Cordis Corporation Implantable valvular prosthesis
US7070616B2 (en) 2003-10-31 2006-07-04 Cordis Corporation Implantable valvular prosthesis
SE526861C2 (sv) 2003-11-17 2005-11-15 Syntach Ag Vävnadslesionsskapande anordning samt en uppsättning av anordningar för behandling av störningar i hjärtrytmregleringssystemet
ATE544477T1 (de) 2003-12-03 2012-02-15 Mayo Foundation Sets für die magnetische beschichtung von medizinprodukten mit lebenden zellen
EP1768604B1 (en) 2003-12-04 2018-01-24 Boston Scientific Scimed, Inc. System for delivering a left atrial appendage containment device
AU2004308348B2 (en) 2003-12-19 2010-12-23 Cardiac Dimensions Pty. Ltd. Device for modifying the shape of a body organ
WO2005058210A1 (en) 2003-12-19 2005-06-30 Patrick Leahy An anti-reflux system
AU2004308508B2 (en) 2003-12-23 2011-03-10 Sadra Medical, Inc. Repositionable heart valve
US20050137696A1 (en) 2003-12-23 2005-06-23 Sadra Medical Apparatus and methods for protecting against embolization during endovascular heart valve replacement
WO2005070343A1 (fr) 2003-12-23 2005-08-04 Laboratoires Perouse Necessaire destine a etre implante dans un conduit
EP2745805B2 (en) 2003-12-23 2022-05-18 Boston Scientific Scimed, Inc. Repositionable heart valve
US8287584B2 (en) 2005-11-14 2012-10-16 Sadra Medical, Inc. Medical implant deployment tool
EP2985006B1 (en) 2003-12-23 2019-06-19 Boston Scientific Scimed, Inc. Repositionable heart valve
US8828078B2 (en) 2003-12-23 2014-09-09 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US7780725B2 (en) 2004-06-16 2010-08-24 Sadra Medical, Inc. Everting heart valve
EP1557138B1 (de) 2004-01-21 2012-12-05 Admedes Schuessler GmbH Expandierbarer Stent mit Koppeleinrichtung
US7597711B2 (en) 2004-01-26 2009-10-06 Arbor Surgical Technologies, Inc. Heart valve assembly with slidable coupling connections
EP1771132B1 (en) 2004-02-03 2019-03-27 V-Wave Ltd. Device and method for controlling in-vivo pressure
EP1561437B1 (en) 2004-02-06 2009-10-28 Sangomed S.R.L. External support for restoring competence to venous valves by traction of their intercommissural walls
WO2005082289A1 (en) 2004-02-20 2005-09-09 Cook Incorporated Prosthetic valve with spacing member
US8206439B2 (en) 2004-02-23 2012-06-26 International Heart Institute Of Montana Foundation Internal prosthesis for reconstruction of cardiac geometry
ITTO20040135A1 (it) 2004-03-03 2004-06-03 Sorin Biomedica Cardio Spa Protesi valvolare cardiaca
WO2005087137A1 (en) 2004-03-08 2005-09-22 Emphasys Medical, Inc. Implanted bronchial isolation devices and methods
EP2308425B2 (en) 2004-03-11 2023-10-18 Percutaneous Cardiovascular Solutions Pty Limited Percutaneous Heart Valve Prosthesis
US8777974B2 (en) 2004-03-19 2014-07-15 Aga Medical Corporation Multi-layer braided structures for occluding vascular defects
NL1025830C2 (nl) 2004-03-26 2005-02-22 Eric Berreklouw Samenstel omvattende een ring voor bevestiging in een door lichaamsweefsel omgeven doorgang alsmede een applicator voor het in de doorgang plaatsen van de ring.
US20050228494A1 (en) 2004-03-29 2005-10-13 Salvador Marquez Controlled separation heart valve frame
KR20070116191A (ko) 2004-03-30 2007-12-06 토요 어드밴스드 테크놀로지스 컴퍼니 리미티드 기재의 표면처리방법, 의료용 재료, 의료용 기구
CA2561188A1 (en) 2004-03-31 2005-10-20 Med Institute, Inc. Endoluminal graft with a prosthetic valve
US7993397B2 (en) 2004-04-05 2011-08-09 Edwards Lifesciences Ag Remotely adjustable coronary sinus implant
US7294148B2 (en) 2004-04-29 2007-11-13 Edwards Lifesciences Corporation Annuloplasty ring for mitral valve prolapse
NL1026076C2 (nl) 2004-04-29 2005-11-01 Univ Eindhoven Tech Vormdeel vervaardigd door middel van elektro-spinnen en een werkwijze voor de vervaardiging daarvan evenals de toepassing van een dergelijk vormdeel.
US8545414B2 (en) 2004-04-30 2013-10-01 St. Jude Medical, Cardiology Division, Inc. Methods and devices for modulation of heart valve function
EP1750592B1 (en) 2004-05-14 2016-12-28 Evalve, Inc. Locking mechanisms for fixation devices
ES2436399T3 (es) 2004-05-14 2013-12-30 St. Jude Medical, Inc. Aparato para sostener y soportar un anillo de anuloplastia
US7785615B2 (en) 2004-05-28 2010-08-31 Cordis Corporation Biodegradable medical implant with encapsulated buffering agent
US7803182B2 (en) 2004-05-28 2010-09-28 Cordis Corporation Biodegradable vascular device with buffering agent
EP1768630B1 (en) 2004-06-16 2015-01-07 Machine Solutions, Inc. Stent crimping device
EP1629795B1 (de) 2004-06-29 2008-01-16 SIEVERS, Hans-Hinrich, Dr. Ringprothese für Anuloplastie
US7462191B2 (en) 2004-06-30 2008-12-09 Edwards Lifesciences Pvt, Inc. Device and method for assisting in the implantation of a prosthetic valve
US7276078B2 (en) 2004-06-30 2007-10-02 Edwards Lifesciences Pvt Paravalvular leak detection, sealing, and prevention
EP1768601A4 (en) 2004-07-15 2007-08-15 Micardia Corp MAGNETIC DEVICES AND METHOD FOR CIRCULATING THE HEART ANATOMY
US7389874B2 (en) 2004-07-19 2008-06-24 St. Jude Medical, Inc. Heart valve support and storing lid system and methods associated therewith
US7585369B2 (en) 2004-08-04 2009-09-08 Larson Marian L Apparatus for coating medical devices
EP1786367B1 (en) 2004-08-27 2013-04-03 Cook Medical Technologies LLC Placement of multiple intraluminal medical devices within a body vessel
CA2578706A1 (en) 2004-09-01 2006-03-16 Cook Incorporated Delivery system which facilitates hydration of an intraluminal medical device
US7566343B2 (en) 2004-09-02 2009-07-28 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
FR2874813B1 (fr) 2004-09-07 2007-06-22 Perouse Soc Par Actions Simpli Prothese valvulaire
US20060052867A1 (en) 2004-09-07 2006-03-09 Medtronic, Inc Replacement prosthetic heart valve, system and method of implant
FR2874812B1 (fr) 2004-09-07 2007-06-15 Perouse Soc Par Actions Simpli Valve protheique interchangeable
US20060135962A1 (en) 2004-09-09 2006-06-22 Kick George F Expandable trans-septal sheath
JP2008513060A (ja) 2004-09-14 2008-05-01 エドワーズ ライフサイエンシーズ アーゲー 心臓弁逆流の処置のためのデバイスおよび方法
CA2748617C (en) 2004-09-27 2014-09-23 Evalve, Inc. Methods and devices for tissue grasping and assessment
AU2004324043A1 (en) 2004-10-02 2006-04-20 Christoph Hans Huber Methods and devices for repair or replacement of heart valves or adjacent tissue without the need for full cardiopulmonary support
US20060079736A1 (en) 2004-10-13 2006-04-13 Sing-Fatt Chin Method and device for percutaneous left ventricular reconstruction
DE602005009974D1 (de) 2004-10-13 2008-11-06 Medtronic Inc Eichung von biologischen oder pharmazeutischen substanzen
EP1833425B1 (en) 2004-12-01 2011-02-23 Cook Incorporated Sensing delivery system for intraluminal medical devices
JP5219518B2 (ja) 2004-12-09 2013-06-26 ザ ファウンドリー， エルエルシー 大動脈弁修復
US7758640B2 (en) 2004-12-16 2010-07-20 Valvexchange Inc. Cardiovascular valve assembly
US7674238B2 (en) 2004-12-23 2010-03-09 Boston Scientific Scimed, Inc. Methods and apparatus for emboli removal
JP5208513B2 (ja) 2004-12-24 2013-06-12 セルクセル プロパティ リミテッド 移植可能なバイオマテリアルおよび同生成する方法
US8287583B2 (en) 2005-01-10 2012-10-16 Taheri Laduca Llc Apparatus and method for deploying an implantable device within the body
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US20060173490A1 (en) 2005-02-01 2006-08-03 Boston Scientific Scimed, Inc. Filter system and method
US7670368B2 (en) 2005-02-07 2010-03-02 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
AU2006212750B2 (en) 2005-02-07 2011-11-17 Evalve, Inc. Methods, systems and devices for cardiac valve repair
WO2011034973A2 (en) 2005-02-07 2011-03-24 Abbott Vascular Methods, systems and devices for cardiac valve repair
ITTO20050074A1 (it) 2005-02-10 2006-08-11 Sorin Biomedica Cardio Srl Protesi valvola cardiaca
EP1693025A1 (en) 2005-02-17 2006-08-23 Universität Zürich Method of manufacturing a tissue-engineered prosthesis
WO2006089236A1 (en) 2005-02-18 2006-08-24 The Cleveland Clinic Foundation Apparatus and methods for replacing a cardiac valve
US20100312333A1 (en) 2009-04-29 2010-12-09 The Cleveland Clinic Foundation Apparatus and method for replacing a diseased cardiac valve
US7867274B2 (en) 2005-02-23 2011-01-11 Boston Scientific Scimed, Inc. Valve apparatus, system and method
CN101340861B (zh) 2005-02-28 2011-08-10 梅德坦提亚国际有限公司 用于改善心脏瓣膜功能的装置和成套工具
US7955385B2 (en) 2005-02-28 2011-06-07 Medtronic Vascular, Inc. Device, system, and method for aiding valve annuloplasty
US7717955B2 (en) 2005-02-28 2010-05-18 Medtronic, Inc. Conformable prosthesis for implanting two-piece heart valves and methods for using them
US9248015B2 (en) 2005-03-11 2016-02-02 Wake Forest University Health Services Production of tissue engineered heart valves
FR2882916B1 (fr) 2005-03-14 2007-06-15 Assist Publ Hopitaux De Paris Dispositif de mesure du diametre d'un panneau aortique
US8454678B2 (en) 2005-03-19 2013-06-04 Cook Biotech Incorporated Prosthetic implants including ECM composite material
KR100691503B1 (ko) 2005-03-21 2007-03-09 (주) 태웅메디칼 식도용 스텐트
US7842085B2 (en) 2005-03-23 2010-11-30 Vaso Adzich Annuloplasty ring and holder combination
US7575595B2 (en) 2005-03-23 2009-08-18 Edwards Lifesciences Corporation Annuloplasty ring and holder combination
CA2602724A1 (en) 2005-03-24 2006-09-28 Cook Incorporated Exchangeable delivery system with distal protection
EP1861045B1 (en) 2005-03-25 2015-03-04 St. Jude Medical, Cardiology Division, Inc. Apparatus for controlling the internal circumference of an anatomic orifice or lumen
FR2883721B1 (fr) 2005-04-05 2007-06-22 Perouse Soc Par Actions Simpli Necessaire destine a etre implante dans un conduit de circulation du sang, et endoprothese tubulaire associee
US8062359B2 (en) 2005-04-06 2011-11-22 Edwards Lifesciences Corporation Highly flexible heart valve connecting band
US7722666B2 (en) 2005-04-15 2010-05-25 Boston Scientific Scimed, Inc. Valve apparatus, system and method
EP1874954B1 (en) 2005-04-27 2017-12-27 Stout Medical Group, L.P. Expandable support device
ATE534346T1 (de) 2005-05-06 2011-12-15 Sorin Biomedica Cardio Srl Annuloplastieprothese
AU2006247571A1 (en) 2005-05-13 2006-11-23 Cook Incorporated Medical device delivery systems that facilitate medical device placement in the presence of ultrasonic waves
US7914569B2 (en) 2005-05-13 2011-03-29 Medtronics Corevalve Llc Heart valve prosthesis and methods of manufacture and use
WO2006125055A2 (en) 2005-05-17 2006-11-23 Cook Incorporated Prosthetic valve devices and methods of making and using such devices
ATE442101T1 (de) 2005-05-17 2009-09-15 Syntach Ag Vorrichtung und kit zur behandlung von stírungen des herzrhythmus-regulierungssystems
EP3292838A1 (en) 2005-05-24 2018-03-14 Edwards Lifesciences Corporation Rapid deployment prosthetic heart valve
US8211169B2 (en) 2005-05-27 2012-07-03 Medtronic, Inc. Gasket with collar for prosthetic heart valves and methods for using them
EP3482717B1 (en) 2005-05-27 2023-09-06 Edwards Lifesciences Corporation Stentless support structure
US8663312B2 (en) 2005-05-27 2014-03-04 Hlt, Inc. Intravascular cuff
US7739971B2 (en) 2005-06-07 2010-06-22 Edwards Lifesciences Corporation Systems and methods for assembling components of a fabric-covered prosthetic heart valve
US8012198B2 (en) 2005-06-10 2011-09-06 Boston Scientific Scimed, Inc. Venous valve, system, and method
US7780723B2 (en) 2005-06-13 2010-08-24 Edwards Lifesciences Corporation Heart valve delivery system
US8685083B2 (en) 2005-06-27 2014-04-01 Edwards Lifesciences Corporation Apparatus, system, and method for treatment of posterior leaflet prolapse
US8663277B2 (en) 2005-06-29 2014-03-04 Ethicon, Inc. Braided barbed suture
JP4558075B2 (ja) 2005-07-08 2010-10-06 北京佰仁医療科技有限公司 心臓の流出路の修復に用いられる弁付きパッチおよび弁付きチューブ
US7776084B2 (en) 2005-07-13 2010-08-17 Edwards Lifesciences Corporation Prosthetic mitral heart valve having a contoured sewing ring
US20070016288A1 (en) 2005-07-13 2007-01-18 Gurskis Donnell W Two-piece percutaneous prosthetic heart valves and methods for making and using them
DE102005032974B4 (de) 2005-07-14 2013-11-07 Siemens Aktiengesellschaft Verfahren zur 3D-Visualisierung vaskulärer Einsatzstücke im menschlichen Körper mit dem C-Bogen
DE602006009113D1 (de) 2005-07-15 2009-10-22 Cleveland Clinic Foundation Vorrichtung zur Ummodellierung eines Herzklappenrings
US8790396B2 (en) 2005-07-27 2014-07-29 Medtronic 3F Therapeutics, Inc. Methods and systems for cardiac valve delivery
NZ565570A (en) 2005-07-29 2011-08-26 Cvdevices Llc Devices and methods for controlling blood perfusion pressure using a retrograde cannula with an inflatable balloon
US20070027528A1 (en) 2005-07-29 2007-02-01 Cook Incorporated Elliptical implantable device
WO2007022519A2 (en) 2005-08-19 2007-02-22 Chf Technologies, Inc. Steerable heart implants for congestive heart failure
US7455689B2 (en) 2005-08-25 2008-11-25 Edwards Lifesciences Corporation Four-leaflet stented mitral heart valve
US9492277B2 (en) 2005-08-30 2016-11-15 Mayo Foundation For Medical Education And Research Soft body tissue remodeling methods and apparatus
US20070061002A1 (en) 2005-09-01 2007-03-15 Cook Incorporated Attachment of material to an implantable frame by cross-linking
MX2008002552A (es) 2005-09-07 2008-04-21 Medtentia Ab Un dispositivo y un metodo para mejorar la funcion de una valvula cardiaca.
US7530253B2 (en) 2005-09-09 2009-05-12 Edwards Lifesciences Corporation Prosthetic valve crimping device
US7712606B2 (en) 2005-09-13 2010-05-11 Sadra Medical, Inc. Two-part package for medical implant
DE102005044009A1 (de) 2005-09-14 2007-03-22 Biophan Europe Gmbh Biologische oder künstliche Klappenprothese zur Verwendung im menschlichen und/oder tierischen Körper zum Einsatz einer Organklappe oder Gefäßklappe
US7972359B2 (en) 2005-09-16 2011-07-05 Atritech, Inc. Intracardiac cage and method of delivering same
US7569071B2 (en) 2005-09-21 2009-08-04 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
WO2007038089A2 (en) 2005-09-21 2007-04-05 Medtronic, Inc. Composite heart valve apparatus manufactured using techniques involving laser machining of tissue
WO2007038540A1 (en) 2005-09-26 2007-04-05 Medtronic, Inc. Prosthetic cardiac and venous valves
US20070073391A1 (en) 2005-09-28 2007-03-29 Henry Bourang System and method for delivering a mitral valve repair device
FR2891134B1 (fr) 2005-09-29 2008-08-22 Jean Noel Fabiani Prothese annulaire pour plastie valvulaire aortique, procede pour plastie valvulaire aortique et combinaison de la prothese annulaire et d'une prothese pour segment aortique
US8007530B2 (en) 2005-09-30 2011-08-30 Medtronic, Inc. Tool and method for implanting an annuloplasty prosthesis
US9265605B2 (en) 2005-10-14 2016-02-23 Boston Scientific Scimed, Inc. Bronchoscopic lung volume reduction valve
US8167932B2 (en) 2005-10-18 2012-05-01 Edwards Lifesciences Corporation Heart valve delivery system with valve catheter
US7503928B2 (en) 2005-10-21 2009-03-17 Cook Biotech Incorporated Artificial valve with center leaflet attachment
EP1951154B1 (en) 2005-10-26 2018-01-24 St. Jude Medical, Inc. Saddle-shaped mitral valve annuloplasty prostheses
US8449606B2 (en) 2005-10-26 2013-05-28 Cardiosolutions, Inc. Balloon mitral spacer
US8092525B2 (en) 2005-10-26 2012-01-10 Cardiosolutions, Inc. Heart valve implant
DE102005051849B4 (de) 2005-10-28 2010-01-21 JenaValve Technology Inc., Wilmington Vorrichtung zur Implantation und Befestigung von Herzklappenprothesen
EP1951155B1 (en) 2005-11-02 2021-05-12 MedicalTree Patents Ltd. Artificial valve for implantation
DE102005052628B4 (de) 2005-11-04 2014-06-05 Jenavalve Technology Inc. Selbstexpandierendes, flexibles Drahtgeflecht mit integrierter Klappenprothese für den transvaskulären Herzklappenersatz und ein System mit einer solchen Vorrichtung und einem Einführkatheter
EP3167847B1 (en) 2005-11-10 2020-10-14 Edwards Lifesciences CardiAQ LLC Heart valve prosthesis
FR2892939B1 (fr) 2005-11-10 2010-01-22 Groupement Coeur Artificiel Total Carpentier Matra Carmat Materiau hemocompatible composite et son procede d'obtention
CN100362971C (zh) 2005-11-16 2008-01-23 程英升 贲门支架
US8764820B2 (en) 2005-11-16 2014-07-01 Edwards Lifesciences Corporation Transapical heart valve delivery system and method
ATE429194T1 (de) 2005-11-16 2009-05-15 Micardia Corp Magnetische befestigung eines katheters an ein implantat
GB0524087D0 (en) 2005-11-25 2006-01-04 Symetis Ag Biodegradable scaffold
FR2894131B1 (fr) 2005-12-02 2008-12-05 Perouse Soc Par Actions Simpli Dispositif de traitement d'un vaisseau sanguin, et necessaire de traitement associe.
EP1959864B1 (en) 2005-12-07 2018-03-07 Medtronic, Inc. Connection systems for two piece prosthetic heart valve assemblies
CA2669188C (en) 2005-12-15 2014-08-05 Georgia Tech Research Corporation Papillary muscle position control devices, systems, & methods
WO2007078772A1 (en) 2005-12-15 2007-07-12 The Cleveland Clinic Foundation Apparatus and method for treating a regurgitant valve
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
EP3398560B8 (en) 2005-12-22 2024-01-10 Boston Scientific Medical Device Limited Systems for surgery and stent valves for replacement
EP1968487B1 (en) 2005-12-23 2019-06-26 Coloplast A/S Medical device
EP1803420B1 (en) 2005-12-28 2009-07-01 Sorin Biomedica Cardio S.R.L. Annuloplasty prosthesis with an auxetic structure
CA2635658A1 (en) 2006-01-04 2007-07-12 Nanopowers S.A. Artificial contractile tissue
US9717468B2 (en) 2006-01-10 2017-08-01 Mediguide Ltd. System and method for positioning an artificial heart valve at the position of a malfunctioning valve of a heart through a percutaneous route
US7799038B2 (en) 2006-01-20 2010-09-21 Boston Scientific Scimed, Inc. Translumenal apparatus, system, and method
EP2583640B1 (en) 2006-02-16 2022-06-22 Venus MedTech (HangZhou), Inc. Minimally invasive replacement heart valve
US8219229B2 (en) 2006-03-02 2012-07-10 Edwards Lifesciences Corporation Virtual heart valve
US7431692B2 (en) 2006-03-09 2008-10-07 Edwards Lifesciences Corporation Apparatus, system, and method for applying and adjusting a tensioning element to a hollow body organ
DE102006013113B4 (de) 2006-03-22 2008-12-11 Vielberg, Heinrich, Dr. med. Ventilgetriebe
US8075615B2 (en) 2006-03-28 2011-12-13 Medtronic, Inc. Prosthetic cardiac valve formed from pericardium material and methods of making same
US7691151B2 (en) 2006-03-31 2010-04-06 Spiration, Inc. Articulable Anchor
RU2325874C2 (ru) 2006-04-04 2008-06-10 Александр Васильевич Самков Протез клапана сердца
FR2899096B1 (fr) 2006-04-04 2008-12-05 Perouse Soc Par Actions Simpli Dispositif de traitement d'un conduit de circulation du sang et procede de preparation de ce dispositif
US20070244556A1 (en) 2006-04-12 2007-10-18 Medtronic Vascular, Inc. Annuloplasty Device Having a Helical Anchor and Methods for its Use
US7806926B2 (en) 2006-04-14 2010-10-05 Edwards Lifesciences Corporation Holders for prosthetic aortic heart valves
CA2649705C (en) 2006-04-19 2015-12-01 William A. Cook Australia Pty. Ltd Twin bifurcated stent graft
CN101442958B (zh) 2006-04-28 2012-09-05 麦德托尼克公司 心脏瓣膜替换设备
WO2007130880A1 (en) 2006-04-29 2007-11-15 Arbor Surgical Technologies, Inc Guide shields for multiple component prosthetic heart valve assemblies and apparatus and methods for using them
US8070800B2 (en) 2006-05-05 2011-12-06 Children's Medical Center Corporation Transcatheter heart valve prostheses
ATE499074T1 (de) 2006-05-15 2011-03-15 Edwards Lifesciences Ag System zur veränderung der geometrie des herzens
EP2018122B1 (en) 2006-05-17 2011-04-20 Syntach AG A controllable device and kit for treatment of disorders in the heart rhythm regulation system
US8932348B2 (en) 2006-05-18 2015-01-13 Edwards Lifesciences Corporation Device and method for improving heart valve function
CA2654359A1 (en) 2006-05-19 2007-11-29 Mitralsolutions, Inc. Implantable devices for controlling the size and shape of an anatomical structure or lumen
CA2653979A1 (en) 2006-05-25 2007-12-06 Interventional And Surgical Innovations, Llc Device for regulating blood flow
AU2007255072A1 (en) 2006-05-30 2007-12-13 Cook Incorporated Artificial valve prosthesis
EP2032080B1 (en) 2006-06-01 2017-05-03 Edwards Lifesciences Corporation Prosthetic insert for improving heart valve function
US8197538B2 (en) 2006-06-02 2012-06-12 Medtronic, Inc. Annuloplasty prosthesis with in vivo shape identification and related methods of use
JP2009539422A (ja) 2006-06-02 2009-11-19 メドトロニック・インコーポレーテッド 弁輪形成用リング及び形成術
ITTO20060413A1 (it) 2006-06-07 2007-12-08 Arrigo Lessana Dispositivo sostitutivo delle corde tendinee di una valvola atrioventricolare
EP1864687B1 (en) 2006-06-09 2013-07-31 Eidgenössische Technische Hochschule Zürich Scaffolds for artificial heart valves and vascular structures
US20080004696A1 (en) 2006-06-29 2008-01-03 Valvexchange Inc. Cardiovascular valve assembly with resizable docking station
JP4981374B2 (ja) 2006-07-10 2012-07-18 パーパス株式会社 細胞又は組織の培養装置及び培養方法
US20080021546A1 (en) 2006-07-18 2008-01-24 Tim Patz System for deploying balloon-expandable heart valves
RU2325873C2 (ru) 2006-07-20 2008-06-10 Александр Васильевич Самков Створка искусственного клапана сердца и способ ее изготовления
US8020503B2 (en) 2006-07-31 2011-09-20 Edwards Lifesciences Corporation Automated surgical implant sewing system and method
US7363821B2 (en) 2006-08-28 2008-04-29 Cordis Corporation Systems and methods for fatigue testing stents
US20080058924A1 (en) 2006-09-01 2008-03-06 Aaron Ingle Saddle-shaped annuloplasty ring
EP2063823B1 (en) 2006-09-01 2018-10-31 Carag AG Devices, system, kit and method for epicardial access
CA2976839C (en) 2006-09-08 2020-04-28 Edwards Lifesciences Corporation Integrated heart valve delivery system
US8834564B2 (en) 2006-09-19 2014-09-16 Medtronic, Inc. Sinus-engaging valve fixation member
US8876894B2 (en) 2006-09-19 2014-11-04 Medtronic Ventor Technologies Ltd. Leaflet-sensitive valve fixation member
US9211115B2 (en) 2006-09-28 2015-12-15 Bioventrix, Inc. Location, time, and/or pressure determining devices, systems, and methods for deployment of lesion-excluding heart implants for treatment of cardiac heart failure and other disease states
FR2906454B1 (fr) 2006-09-28 2009-04-10 Perouse Soc Par Actions Simpli Implant destine a etre place dans un conduit de circulation du sang.
US7534261B2 (en) 2006-10-02 2009-05-19 Edwards Lifesciences Corporation Sutureless heart valve attachment
US7575592B2 (en) 2006-10-03 2009-08-18 St. Jude Medical, Inc. Synthetic blood vessel grafts
US8029556B2 (en) 2006-10-04 2011-10-04 Edwards Lifesciences Corporation Method and apparatus for reshaping a ventricle
US8163011B2 (en) 2006-10-06 2012-04-24 BioStable Science & Engineering, Inc. Intra-annular mounting frame for aortic valve repair
FR2906998B1 (fr) 2006-10-16 2009-04-10 Perouse Soc Par Actions Simpli Implant destine a etre place dans un conduit de circulation du sang.
US8388680B2 (en) 2006-10-18 2013-03-05 Guided Delivery Systems, Inc. Methods and devices for catheter advancement and delivery of substances therethrough
WO2008073582A2 (en) 2006-10-27 2008-06-19 Edwards Lifesciences Corporation Biological tissue for surgical implantation
DE102006052564B3 (de) 2006-11-06 2007-12-13 Georg Lutter Mitralklappenstent
US8167926B2 (en) 2006-11-07 2012-05-01 Cook Medical Technologies Llc Fenestration for stent graft arrangements and stent graft including the same
EP1920789A1 (en) 2006-11-11 2008-05-14 Universitätsklinikum Hamburg-Eppendorf Pouch-like construct comprising mammalian tissue
SE530568C2 (sv) 2006-11-13 2008-07-08 Medtentia Ab Anordning och metod för förbättring av funktionen hos en hjärtklaff
US8211171B2 (en) 2006-11-14 2012-07-03 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Transcatheter coronary sinus mitral valve annuloplasty procedure and coronary artery and myocardial protection device
AU2007330338A1 (en) 2006-12-05 2008-06-12 Valtech Cardio, Ltd. Segmented ring placement
JP5593545B2 (ja) 2006-12-06 2014-09-24 メドトロニック シーブイ ルクセンブルク エス．アー．エール．エル． 弁輪に固定された自己拡張型弁の経心尖的送達のためのシステムおよび方法
FR2909857B1 (fr) 2006-12-14 2009-03-06 Perouse Soc Par Actions Simpli Endovalve.
US8353954B2 (en) 2006-12-19 2013-01-15 St. Jude Medical, Inc. Prosthetic heart valve including stent structure and tissue leaflets, and related methods
EP1935378B1 (en) 2006-12-19 2014-09-17 Sorin Group Italia S.r.l. Instrument for in situ positioning of cardiac valve prostheses
DE602006013167D1 (de) 2006-12-19 2010-05-06 Sorin Biomedica Cardio Srl Instrument zum in-situ-Einsetzen von Herzklappenprothesen
FR2910269B1 (fr) 2006-12-22 2009-02-27 Corevalve Inc Materiel de traitement d'une valve cardiaque,en particulier d'une valve mitrale
US8236045B2 (en) 2006-12-22 2012-08-07 Edwards Lifesciences Corporation Implantable prosthetic valve assembly and method of making the same
JP5443169B2 (ja) 2007-01-03 2014-03-19 ミトラル・ソリューションズ・インコーポレイテッド 解剖学的構造又は内腔のサイズ及び形状を制御するための移植可能な装置
DE602007004180D1 (de) 2007-01-15 2010-02-25 Chang Jen Ping Vorrichtung zur Prüfung der Tüchtigkeit einer Aortenklappe und einer Pulmonalklappe
EP2444031B1 (en) 2007-01-19 2015-07-15 Medtronic, Inc. Stent delivery device
EP2124825B1 (en) 2007-01-26 2018-10-24 Medtronic, Inc. Annuloplasty device for tricuspid valve repair
DE102007005900A1 (de) 2007-02-01 2008-08-07 Endosmart Gesellschaft für innovative Medizintechnik mbH Instrument zum operativen Entfernen einer defekten Herzklappe
CA2670589A1 (en) 2007-02-05 2008-08-14 Boston Scientific Limited Percutaneous valve, system and method
US9415567B2 (en) 2007-02-05 2016-08-16 Boston Scientific Scimed, Inc. Synthetic composite structures
ES2441801T3 (es) 2007-02-05 2014-02-06 Boston Scientific Limited Válvula percutánea y sistema de suministro
JP2010517625A (ja) 2007-02-05 2010-05-27 ボストン サイエンティフィック リミテッド 合成複合材料構造
US20090157176A1 (en) 2007-02-09 2009-06-18 Alain Carpentier Annuloplasty rings for correcting degenerative valvular diseases
EP2114304B1 (en) 2007-02-14 2017-09-06 Edwards Lifesciences Corporation implantable medical device for repairing heart
CA2677633C (en) 2007-02-15 2015-09-08 Medtronic, Inc. Multi-layered stents and methods of implanting
ATE515244T1 (de) 2007-02-15 2011-07-15 Cook Inc Künstliche klappenprothese mit freiem blattabschnitt
EP2117476B1 (de) 2007-02-16 2014-01-22 Universität Zürich Rohrförmige stützprothese mit herzklappe insbesondere für aortenklappenersatz
CA2677648C (en) 2007-02-16 2015-10-27 Medtronic, Inc. Replacement prosthetic heart valves and methods of implantation
EP1958598A1 (de) 2007-02-16 2008-08-20 Universität Zürich Wachstumsfähige, rohrförmige Stützprothese
DE102007010305A1 (de) 2007-02-22 2008-08-28 Jotec Gmbh Vorrichtung zum Freisetzen eines selbstexpandierenden Stents in ein Körpergefäß
US8221505B2 (en) 2007-02-22 2012-07-17 Cook Medical Technologies Llc Prosthesis having a sleeve valve
US20080208328A1 (en) 2007-02-23 2008-08-28 Endovalve, Inc. Systems and Methods For Placement of Valve Prosthesis System
US20080208327A1 (en) 2007-02-27 2008-08-28 Rowe Stanton J Method and apparatus for replacing a prosthetic valve
US8100959B2 (en) 2007-03-09 2012-01-24 Pulmonx Corporation Loading device for a pulmonary implant
US8303622B2 (en) 2007-03-14 2012-11-06 St. Jude Medical, Inc. Heart valve chordae replacement methods and apparatus
FR2913879B1 (fr) 2007-03-21 2009-06-12 Perouse Soc Par Actions Simpli Dispositif de largage d'un implant expansible radialement, necessaire de traitement et procede de largage associe
JP5114548B2 (ja) 2007-04-13 2013-01-09 イエナバルブ テクノロジー インク 心臓弁の機能不全または狭窄症を治療するための医療用デバイス
US9138315B2 (en) 2007-04-13 2015-09-22 Jenavalve Technology Gmbh Medical device for treating a heart valve insufficiency or stenosis
US8409274B2 (en) 2007-04-26 2013-04-02 St. Jude Medical, Inc. Techniques for attaching flexible leaflets of prosthetic heart valves to supporting structures
US8529620B2 (en) 2007-05-01 2013-09-10 Ottavio Alfieri Inwardly-bowed tricuspid annuloplasty ring
FR2915678B1 (fr) 2007-05-02 2010-04-16 Lapeyre Ind Llc Valve cardiaque prothetique mecanique
US8147504B2 (en) 2007-05-05 2012-04-03 Medtronic, Inc. Apparatus and methods for delivering fasteners during valve replacement
FR2915903B1 (fr) 2007-05-10 2010-06-04 Carpentier Matra Carmat Procede pour la realisation d'un objet hemocompatible de configuration complexe et objet ainsi obtenu.
EP2659861B1 (en) 2007-05-15 2019-03-13 JenaValve Technology, Inc. Handle for manipulating a catheter tip, catheter system and medical insertion system for inserting a self-expandable heart valve stent
US8403979B2 (en) 2007-05-17 2013-03-26 Cook Medical Technologies Llc Monocuspid prosthetic valve having a partial sinus
ATE459307T1 (de) 2007-05-21 2010-03-15 Sala Berardino Della ELEKTROMAGNETISCH SCHLIEßBARES RÜCKSCHLAGVENTIL FÜR BIOLOGISCHE FLÜSSIGKEITPUMPEN
FR2916627B1 (fr) 2007-05-30 2010-09-17 Perouse Lab Necessaire de traitement d'un conduit de circulation du sang
JP5367700B2 (ja) 2007-06-04 2013-12-11 セント ジュード メディカル インコーポレイテッド 人工心臓弁
FR2916959B1 (fr) 2007-06-08 2009-09-04 Perouse Soc Par Actions Simpli Necessaire destine a etre implante dans un conduit de circulation de sang
US9101691B2 (en) 2007-06-11 2015-08-11 Edwards Lifesciences Corporation Methods for pre-stressing and capping bioprosthetic tissue
ES2475144T3 (es) 2007-06-26 2014-07-10 St. Jude Medical, Inc. Aparato para la implantación de válvulas prot�sicas de corazón replegables / expansibles
DE102007031146A1 (de) 2007-06-27 2009-01-08 Aesculap Ag Sinusflicken zum Ersatz von defekten Sinus an der Aortenwurzel
DE102007031148A1 (de) 2007-06-27 2009-01-08 Aesculap Ag Aortensinusprothese
EP2014257B1 (en) 2007-07-12 2010-09-08 Sorin Biomedica Cardio S.R.L. Expandable prosthetic valve crimping device
US9308086B2 (en) 2010-09-21 2016-04-12 Hocor Cardiovascular Technologies Llc Method and system for balloon counterpulsation during aortic valve replacement
US8663319B2 (en) 2007-07-23 2014-03-04 Hocor Cardiovascular Technologies Llc Methods and apparatus for percutaneous aortic valve replacement
US8828079B2 (en) 2007-07-26 2014-09-09 Boston Scientific Scimed, Inc. Circulatory valve, system and method
US9566178B2 (en) 2010-06-24 2017-02-14 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
EP2219558B8 (en) 2007-08-21 2015-09-23 Symetis SA Stent-valves for valve replacement and associated systems for surgery
AU2008288796B2 (en) 2007-08-23 2014-03-20 Dfm, Llc Cardiovascular prosthetic valve
EP2484311B1 (en) 2007-08-24 2015-05-06 St. Jude Medical, Inc. Prosthetic aortic heart valve
US8834551B2 (en) 2007-08-31 2014-09-16 Rex Medical, L.P. Vascular device with valve for approximating vessel wall
US8092363B2 (en) 2007-09-05 2012-01-10 Mardil, Inc. Heart band with fillable chambers to modify heart valve function
EP2033593B1 (en) 2007-09-07 2012-10-31 Sorin Biomedica Cardio S.R.L. "Microprocessor controlled delivery system for cardiac valve prosthesis"
CA2698388C (en) 2007-09-07 2015-11-24 Edwards Lifesciences Corporation Active holder for annuloplasty ring delivery
FR2920664B1 (fr) 2007-09-11 2010-09-10 Perouse Lab Dispositif de traitement d'un conduit de circulation du sang
FR2932376B1 (fr) 2008-06-11 2011-04-01 Perouse Lab Dispositif de traitement d'un conduit de circulation du sang
DE102007043830A1 (de) 2007-09-13 2009-04-02 Lozonschi, Lucian, Madison Herzklappenstent
BRPI0817708A2 (pt) 2007-09-26 2017-05-16 St Jude Medical válvula cardíaca protética, e, estrutura de lamela para a mesma.
US8043301B2 (en) 2007-10-12 2011-10-25 Spiration, Inc. Valve loader method, system, and apparatus
US8136230B2 (en) 2007-10-12 2012-03-20 Spiration, Inc. Valve loader method, system, and apparatus
CA2702672C (en) 2007-10-15 2016-03-15 Edwards Lifesciences Corporation Transcatheter heart valve with micro-anchors
US20090105813A1 (en) 2007-10-17 2009-04-23 Sean Chambers Implantable valve device
EP2205183B1 (en) 2007-10-25 2018-11-28 Symetis SA A system for replacing a cardiac valve
WO2009061389A2 (en) 2007-11-05 2009-05-14 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with non-expanding stent posts and retrieval features
US8715337B2 (en) 2007-11-09 2014-05-06 Cook Medical Technologies Llc Aortic valve stent graft
US8313526B2 (en) 2007-11-19 2012-11-20 Cook Medical Technologies Llc Valve frame
DE102007061301A1 (de) 2007-12-10 2009-06-18 Aesculap Ag Ummantelung zur Wiederherstellung der Klappenfunktion variköser Venen und Verwendung der Ummantelung in der Chirurgie
EP2231070B1 (en) 2007-12-14 2013-05-22 Edwards Lifesciences Corporation Leaflet attachment frame for a prosthetic valve
US7892276B2 (en) 2007-12-21 2011-02-22 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
US8357387B2 (en) 2007-12-21 2013-01-22 Edwards Lifesciences Corporation Capping bioprosthetic tissue to reduce calcification
EP2072027B1 (en) 2007-12-21 2020-06-17 Medtentia International Ltd Oy pre-annuloplasty device and method
US20090171456A1 (en) 2007-12-28 2009-07-02 Kveen Graig L Percutaneous heart valve, system, and method
CA2711245C (en) 2008-01-04 2018-05-01 Interventional And Surgical Innovations, Llc Device for regulating blood flow
US9180004B2 (en) 2008-01-16 2015-11-10 St. Jude Medical, Inc. Delivery and retrieval systems for collapsible/expandable prosthetic heart valves
EP3449875B1 (en) 2008-01-24 2025-10-15 Medtronic, Inc. Stents for prosthetic heart valves
EP2254513B1 (en) 2008-01-24 2015-10-28 Medtronic, Inc. Stents for prosthetic heart valves
EP2254512B1 (en) 2008-01-24 2016-01-06 Medtronic, Inc. Markers for prosthetic heart valves
US8157853B2 (en) 2008-01-24 2012-04-17 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
AU2009206340B2 (en) 2008-01-24 2012-06-14 Medtronic Vascular Inc. Infundibular reducer device delivery system and related methods
EP2082690B1 (en) 2008-01-24 2012-06-20 Kardium, Inc. Medical device to assist diastolic function and prevent ventricular enlargement
US7993395B2 (en) 2008-01-25 2011-08-09 Medtronic, Inc. Set of annuloplasty devices with varying anterior-posterior ratios and related methods
AU2009212393B2 (en) 2008-02-06 2014-07-24 Ancora Heart, Inc. Multi-window guide tunnel
WO2009099644A1 (en) 2008-02-08 2009-08-13 Heartware, Inc. Ventricular assist device for intraventricular placement
ATE551016T1 (de) 2008-02-11 2012-04-15 Corassist Cardiovascular Ltd Hilfsvorrichtungen für ventrikuläre funktion
CA2715448C (en) 2008-02-25 2017-06-13 Medtronic Vascular Inc. Infundibular reducer devices
ES2488119T3 (es) 2008-02-26 2014-08-26 Jenavalve Technology Gmbh Estent para la colocación y el anclaje de una prótesis valvular en un sitio de implantación en el corazón de un paciente
WO2009108355A1 (en) 2008-02-28 2009-09-03 Medtronic, Inc. Prosthetic heart valve systems
EP2594230B1 (en) 2008-02-29 2021-04-28 Edwards Lifesciences Corporation Expandable member for deploying a prosthetic device
DE102008012438B4 (de) 2008-02-29 2014-12-24 Nvt Ag Mechanische Aortenklappe für die endovaskuläre Implantation
DE102008012113A1 (de) 2008-03-02 2009-09-03 Transcatheter Technologies Gmbh Stent, welcher vom expandierten Zustand erneut im Durchmesser kontrolliert verringerbar ist
US8313525B2 (en) 2008-03-18 2012-11-20 Medtronic Ventor Technologies, Ltd. Valve suturing and implantation procedures
DE102008015781B4 (de) 2008-03-26 2011-09-29 Malte Neuss Vorrichtung zum Verschluss von Defekten im Gefäßsystem
EP2105110B2 (en) 2008-03-27 2018-03-21 Genomnia S.r.l. Valve prosthesis for implantation in body channels
US7815673B2 (en) 2008-04-01 2010-10-19 Medtronic Vascular, Inc. Double-walled stent system
US8430927B2 (en) 2008-04-08 2013-04-30 Medtronic, Inc. Multiple orifice implantable heart valve and methods of implantation
JP5734178B2 (ja) 2008-04-09 2015-06-10 ジョージア テック リサーチ コーポレイション 心臓弁を修復するための弁形成リングおよび方法
US8262725B2 (en) 2008-04-16 2012-09-11 Cardiovascular Technologies, Llc Transvalvular intraannular band for valve repair
FR2930137B1 (fr) 2008-04-18 2010-04-23 Corevalve Inc Materiel de traitement d'une valve cardiaque, en particulier d'une valve mitrale.
WO2009130631A2 (en) 2008-04-21 2009-10-29 Simcha Milo Surgical stapling systems
BRPI0911351B8 (pt) 2008-04-23 2021-06-22 Medtronic Inc estrutura de stent para uma válvula cardíaca protética, e, prótese de válvula cardíaca
US9061119B2 (en) 2008-05-09 2015-06-23 Edwards Lifesciences Corporation Low profile delivery system for transcatheter heart valve
US8152844B2 (en) 2008-05-09 2012-04-10 Edwards Lifesciences Corporation Quick-release annuloplasty ring holder
CA2964035C (en) 2008-05-09 2018-09-04 Edwards Lifesciences Corporation Degenerative valvular disease specific annuloplasty rings
US20090287303A1 (en) 2008-05-13 2009-11-19 Edwards Lifesciences Corporation Physiologically harmonized tricuspid annuloplasty ring
US8668668B2 (en) 2008-05-14 2014-03-11 Onset Medical Corporation Expandable iliac sheath and method of use
US8840661B2 (en) 2008-05-16 2014-09-23 Sorin Group Italia S.R.L. Atraumatic prosthetic heart valve prosthesis
GB0809357D0 (en) 2008-05-22 2008-07-02 Punjabi Prakash Heart valve repair device
CA2726807C (en) 2008-06-05 2016-05-31 Medtronic, Inc. Connection systems for two piece prosthetic heart valve assemblies and methods for making and using them
CA3272264A1 (en) 2008-06-06 2025-10-30 Edwards Lifesciences Corporation Low profile transcatheter heart valve
CA2728078A1 (en) 2008-06-16 2010-01-14 Valtech Cardio, Ltd. Annuloplasty devices and methods of delivery therefor
US8323335B2 (en) 2008-06-20 2012-12-04 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves and methods for using
DK2296581T3 (en) 2008-06-20 2018-02-26 Coloplast As biomaterial
US8206635B2 (en) 2008-06-20 2012-06-26 Amaranth Medical Pte. Stent fabrication via tubular casting processes
WO2009153771A1 (en) 2008-06-20 2009-12-23 Vysera Biomedical Limited Esophageal valve
EP2303384B1 (en) 2008-06-23 2015-08-12 Lumen Biomedical, Inc. Embolic protection during percutaneous heart valve replacement and similar procedures
JP5379853B2 (ja) 2008-07-15 2013-12-25 セント ジュード メディカル インコーポレイテッド 軸線方向に固定する、潰れ可能かつ再膨張可能な多種症状用人工心臓弁
EP2815724B2 (en) 2008-07-15 2024-03-13 St. Jude Medical, Inc. Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications
BRPI0822756B8 (pt) 2008-07-17 2021-06-22 Nvt Ag sistema de prótese de válvula cardíaca e processo para produzir prótese de válvula cardíaca
AU2009274131B2 (en) 2008-07-21 2015-06-04 Jennifer K. White Repositionable endoluminal support structure and its applications
WO2010011674A1 (en) 2008-07-21 2010-01-28 Bioventrix Cardiac anchor structures
RU2373900C1 (ru) 2008-07-23 2009-11-27 Закрытое Акционерное Общество Научно-Производственное Предприятие "Мединж" Протез клапана сердца
US9232992B2 (en) 2008-07-24 2016-01-12 Aga Medical Corporation Multi-layered medical device for treating a target site and associated method
ES2659322T3 (es) 2008-07-27 2018-03-14 Pi-R-Squared Ltd. Fracturación de calcificaciones en válvulas cardíacas
BRPI0916696A2 (pt) 2008-07-29 2015-11-17 St Jude Medical Cardiology Div método e sistema para ajuste a longo prazo de um dispositivo de implante
US8337390B2 (en) 2008-07-30 2012-12-25 Cube S.R.L. Intracardiac device for restoring the functional elasticity of the cardiac structures, holding tool for the intracardiac device, and method for implantation of the intracardiac device in the heart
EP2340055B1 (en) 2008-08-19 2017-01-25 DSM IP Assets B.V. Implantable valve prosthesis and method for manufacturing such a valve
US8652202B2 (en) 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
JP5611948B2 (ja) 2008-08-25 2014-10-22 カーディオキネティックス・インコーポレイテッドＣａｒｄｉｏｋｉｎｅｔｉｘ， Ｉｎｃ． 回収可能心臓用装置
US8998981B2 (en) 2008-09-15 2015-04-07 Medtronic, Inc. Prosthetic heart valve having identifiers for aiding in radiographic positioning
US20100100174A1 (en) 2008-09-15 2010-04-22 Gurskis Donnell W Tools, systems, and methods for remodeling tissue
US8721714B2 (en) 2008-09-17 2014-05-13 Medtronic Corevalve Llc Delivery system for deployment of medical devices
WO2010033931A2 (en) 2008-09-19 2010-03-25 Edwards Lifesciences Corporation Prosthetic heart valve configured to receive a percutaneous prosthetic heart valve implantation
WO2010033936A2 (en) 2008-09-19 2010-03-25 Edwards Lifesciences Corporation Annuloplasty ring configured to receive a percutaneous prosthetic heart valve implantation
US9375310B2 (en) 2012-12-31 2016-06-28 Edwards Lifesciences Corporation Surgical heart valves adapted for post-implant expansion
CN102292053A (zh) 2008-09-29 2011-12-21 卡迪尔克阀门技术公司 心脏瓣膜
CA2739275C (en) 2008-10-01 2017-01-17 Impala, Inc. Delivery system for vascular implant
WO2010041125A1 (en) 2008-10-09 2010-04-15 Peter Paul Zilla A stent deployment device
NL1036038C (en) 2008-10-09 2010-04-14 Univ Eindhoven Tech Multilayer preform obtained by electro-spinning, method for producing a preform as well as use thereof.
EP2349097B1 (en) 2008-10-10 2024-07-03 MedicalTree Patent Ltd. An improved artificial valve
JP5607639B2 (ja) 2008-10-10 2014-10-15 サドラ メディカル インコーポレイテッド 医療用デバイス・システム
CN102281834B (zh) 2008-10-10 2017-08-22 卡斯滕·尼尔斯·古特 用于植入的装置和用于植入的方法
EP2349096B1 (en) 2008-10-10 2021-01-27 MedicalTree Patent Ltd. An improved artificial valve
US10226329B2 (en) 2008-10-10 2019-03-12 Peter Forsell Artificial valve
US8137398B2 (en) 2008-10-13 2012-03-20 Medtronic Ventor Technologies Ltd Prosthetic valve having tapered tip when compressed for delivery
US8449625B2 (en) 2009-10-27 2013-05-28 Edwards Lifesciences Corporation Methods of measuring heart valve annuluses for valve replacement
US8986361B2 (en) 2008-10-17 2015-03-24 Medtronic Corevalve, Inc. Delivery system for deployment of medical devices
CA2740443C (en) 2008-10-20 2016-06-21 Corassist Cardiovascular Ltd. Ventricular function assisting device and a method and apparatus for implanting it
US9119715B2 (en) 2008-10-30 2015-09-01 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valve delivery system and methods
US9682242B2 (en) 2008-11-14 2017-06-20 Bal Seal Engineering, Inc. Connector with low lead insertion force and method of reducing same
WO2010057262A1 (en) 2008-11-21 2010-05-27 Percutaneous Cardiovascular Solutions Pty Limited Heart valve prosthesis and method
US8591567B2 (en) 2008-11-25 2013-11-26 Edwards Lifesciences Corporation Apparatus and method for in situ expansion of prosthetic device
JP5530455B2 (ja) 2008-12-04 2014-06-25 ジョージア テック リサーチ コーポレーション 低侵襲心臓弁処置のための装置
US8591573B2 (en) 2008-12-08 2013-11-26 Hector Daniel Barone Prosthetic valve for intraluminal implantation
WO2010067300A1 (en) 2008-12-12 2010-06-17 Koninklijke Philips Electronics N. V. Automatic road mapping for heart valve replacement
US8177802B2 (en) 2008-12-16 2012-05-15 Medtronic Vascular, Inc. Apparatus for percutaneously creating native tissue venous valves
JP5797115B2 (ja) 2008-12-19 2015-10-21 ケイエル メディカル エルエルシー 心臓への内視鏡によるアクセスのための装置とシステム
US8308798B2 (en) 2008-12-19 2012-11-13 Edwards Lifesciences Corporation Quick-connect prosthetic heart valve and methods
US8808368B2 (en) 2008-12-22 2014-08-19 Valtech Cardio, Ltd. Implantation of repair chords in the heart
EP3848002A1 (en) 2008-12-22 2021-07-14 Valtech Cardio, Ltd. Adjustable annuloplasty devices and adjustment mechanisms therefor
US8545553B2 (en) 2009-05-04 2013-10-01 Valtech Cardio, Ltd. Over-wire rotation tool
EP2201911B1 (en) 2008-12-23 2015-09-30 Sorin Group Italia S.r.l. Expandable prosthetic valve having anchoring appendages
EP2381895B1 (en) 2008-12-31 2021-07-07 Medtronic, Inc. Semi-rigid annuloplasty ring and band and method of making an annuloplasty ring
WO2010080884A1 (en) 2009-01-07 2010-07-15 Cook Incorporated Implantable valve prosthesis with independent frame elements
US9402720B2 (en) 2009-01-12 2016-08-02 Valve Medical Ltd. Modular percutaneous valve structure and delivery method
US9681950B2 (en) 2009-01-12 2017-06-20 Valve Medical Ltd. System and method for placing a percutaneous valve device
US8998982B2 (en) 2009-01-12 2015-04-07 Valve Medical Ltd. Method and apparatus for fine adjustment of a percutaneous valve structure
US9204965B2 (en) 2009-01-14 2015-12-08 Lc Therapeutics, Inc. Synthetic chord
EP2389121B1 (en) 2009-01-22 2020-10-07 St. Jude Medical, Cardiology Division, Inc. Post-operative adjustment tool, minimally invasive attachment apparatus, and adjustable tricuspid ring
AU2010206658A1 (en) 2009-01-22 2011-08-25 St. Jude Medical, Cardiology Division, Inc. Magnetic docking system and method for the long term adjustment of an implantable device
EP2384185A2 (en) 2009-01-28 2011-11-09 The Procter & Gamble Company Methods for improving skin quality using rinse-off personal care compositions with variable amounts of hydrophobic benefit agents
JP5662353B2 (ja) 2009-02-06 2015-01-28 セント・ジュード・メディカル，インコーポレイテッド 心臓弁輪サイザー
EP2393449B1 (en) 2009-02-06 2016-09-07 St. Jude Medical, Inc. Support for adjustable annuloplasty ring
AU2010210404A1 (en) 2009-02-09 2011-08-25 St. Jude Medical, Cardiology Division, Inc. Inflatable minimally invasive system for delivering and securing an annular implant
US20120010636A1 (en) 2009-02-11 2012-01-12 Nanyang Technological University Multi-layered surgical prosthesis
WO2010091653A1 (de) 2009-02-11 2010-08-19 Georg Lutter Katheter
DE102009009158B4 (de) 2009-02-16 2010-11-04 Siemens Aktiengesellschaft Lokalisierung eines medizinischen Instruments in einem präinvasiv aufgenommenen Tomographie-Bilddatensatz
EP2398421B1 (en) 2009-02-20 2017-09-27 St. Jude Medical, Inc. Devices and methods for collapsing prosthetic heart valves
EP3610833B1 (en) 2009-02-24 2024-05-29 Cook Medical Technologies LLC Low profile support frame
US8348997B2 (en) 2009-02-24 2013-01-08 Medtronic Vascular, Inc. One-way replacement valve
EP3181096B1 (en) 2009-02-25 2025-10-08 JenaValve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US20100217382A1 (en) 2009-02-25 2010-08-26 Edwards Lifesciences Mitral valve replacement with atrial anchoring
WO2010098857A1 (en) 2009-02-27 2010-09-02 St. Jude Medical, Inc. Stent features for collapsible prosthetic heart valves
US8021420B2 (en) 2009-03-12 2011-09-20 Medtronic Vascular, Inc. Prosthetic valve delivery system
RU2393818C1 (ru) 2009-03-19 2010-07-10 Закрытое Акционерное Общество Научно-Производственное Предприятие "Мединж" Реимплантируемый протез клапана сердца и инструмент для его установки
EP2410947B1 (en) 2009-03-26 2015-05-20 Sorin Group USA, Inc. Annuloplasty sizers for minimally invasive procedures
CN101919753A (zh) 2009-03-30 2010-12-22 卡迪万蒂奇医药公司 人工主动脉瓣膜或二尖瓣膜的无缝合移植方法和装置
GB0905444D0 (en) 2009-03-30 2009-05-13 Ucl Business Plc Heart valve prosthesis
EP3081195B1 (en) 2009-04-10 2018-10-03 Lon Sutherland Annest An implantable scaffolding containing an orifice for use with a prosthetic or bio-prosthetic valve
AU2009344181A1 (en) 2009-04-10 2011-10-13 Cardiokinetix, Inc. Sealing and filling ventricular partitioning devices to improve cardiac function
AU2010236288A1 (en) 2009-04-15 2011-10-20 Cardiaq Valve Technologies, Inc. Vascular implant and delivery system
BRPI1014971A2 (pt) 2009-04-15 2016-04-26 Microvention Inc sistema de distribuição de implantes.
ES2523218T3 (es) 2009-04-27 2014-11-24 Sorin Group Italia S.R.L. Conducto vascular protésico
CA2778129C (en) 2009-04-28 2014-09-02 Dc Devices, Inc. Devices, systems and methods to treat heart failure
US9034034B2 (en) 2010-12-22 2015-05-19 V-Wave Ltd. Devices for reducing left atrial pressure, and methods of making and using same
EP2427143B1 (en) 2009-05-04 2017-08-02 V-Wave Ltd. Device for regulating pressure in a heart chamber
US8523881B2 (en) 2010-07-26 2013-09-03 Valtech Cardio, Ltd. Multiple anchor delivery tool
CN102438551A (zh) 2009-05-08 2012-05-02 皇家飞利浦电子股份有限公司 可植入医疗装置的超声规划和引导
US8403982B2 (en) 2009-05-13 2013-03-26 Sorin Group Italia S.R.L. Device for the in situ delivery of heart valves
ES2549429T3 (es) 2009-05-13 2015-10-28 Sorin Group Italia S.R.L. Dispositivo de suministro in situ de válvulas cardiacas
US9168105B2 (en) 2009-05-13 2015-10-27 Sorin Group Italia S.R.L. Device for surgical interventions
FR2945440B1 (fr) 2009-05-14 2012-12-07 Perouse Lab Dispositif de traitement et necessaire de traitement d'un conduit de circulation du sang
US8075611B2 (en) 2009-06-02 2011-12-13 Medtronic, Inc. Stented prosthetic heart valves
DE102009024648B4 (de) 2009-06-03 2018-05-09 Aesculap Ag Markierte Venen-Ummantelung, insbesondere zur Wiederherstellung der Venenklappenfunktion variköser Venen
US8348998B2 (en) 2009-06-26 2013-01-08 Edwards Lifesciences Corporation Unitary quick connect prosthetic heart valve and deployment system and methods
FR2947716B1 (fr) 2009-07-10 2011-09-02 Cormove Implant prothetique ameliore
US8475522B2 (en) 2009-07-14 2013-07-02 Edwards Lifesciences Corporation Transapical delivery system for heart valves
SG177591A1 (en) 2009-07-14 2012-03-29 Edwards Lifesciences Corp Transapical delivery system for heart valves
US9346971B2 (en) 2009-07-15 2016-05-24 Technical University Of Denmark Polymer coating comprising 2-methoxyethyl acrylate units synthesized by surface-initiated atom transfer radical polymerization
US9028546B2 (en) 2009-07-17 2015-05-12 Peter Forsell Artificial valve for implantation
CN102781520B (zh) 2009-07-17 2016-06-08 帕夫泰克技术私人有限公司 呼吸器
JP5716024B2 (ja) 2009-07-22 2015-05-13 ザ テキサス エー アンド エム ユニヴァーシティー システムＴｈｅ Ｔｅｘａｓ Ａ＆Ｍ Ｕｎｉｖｅｒｓｉｔｙ Ｓｙｓｔｅｍ 心臓病態を治療するための補助及びリコイル機能を備える二相性及び動的調整可能サポートデバイス及び方法
US20110022165A1 (en) 2009-07-23 2011-01-27 Edwards Lifesciences Corporation Introducer for prosthetic heart valve
ES2549000T3 (es) 2009-07-27 2015-10-22 Endologix, Inc. Endoprótesis
US8500757B2 (en) 2009-07-28 2013-08-06 Edwards Lifesciences Corporation Surgical puncture cinch and closure system
US8456926B2 (en) 2010-11-18 2013-06-04 Grandis, Inc. Memory write error correction circuit
EP2467104B1 (en) 2009-08-20 2016-11-02 Cook Medical Technologies LLC Loading apparatus and system for expandable intraluminal medical devices
JP5744028B2 (ja) 2009-08-27 2015-07-01 メドトロニック，インコーポレイテッド 経カテーテル弁搬送システムおよび方法
CA2772358C (en) 2009-08-28 2018-05-22 3F Therapeutics, Inc. Transapical delivery device and method of use
CN102762170B (zh) 2009-08-28 2016-02-10 美敦力3F医疗有限公司 皱缩装置
AU2010286524B2 (en) 2009-08-28 2014-09-04 Medtronic 3F Therapeutics, Inc. Surgical delivery device and method of use
CN102647957B (zh) 2009-09-11 2015-04-29 Gi动力公司 具有张开头部的锚固器
EP2633821B1 (en) 2009-09-15 2016-04-06 Evalve, Inc. Device for cardiac valve repair
CN102548508B (zh) 2009-09-21 2015-06-03 麦德托尼克公司 带支架的经导管假体心脏瓣膜输送系统及方法
US8652203B2 (en) 2010-09-23 2014-02-18 Cardiaq Valve Technologies, Inc. Replacement heart valves, delivery devices and methods
WO2011041571A2 (en) 2009-10-01 2011-04-07 Kardium Inc. Medical device, kit and method for constricting tissue or a bodily orifice, for example, a mitral valve
EP2488126B1 (en) 2009-10-14 2022-04-13 Cardiovascular Technologies, Llc Percutaneous transvalvular intraannular band for mitral valve repair
FR2951549B1 (fr) 2009-10-15 2013-08-23 Olivier Schussler Procede d'obtention de bioprotheses medicales implantables
AU2010315535A1 (en) 2009-10-26 2012-05-03 Cardiokinetix, Inc. Ventricular volume reduction
WO2011154942A2 (en) 2010-06-07 2011-12-15 Valtech Cardio, Ltd. Apparatus and method for guide-wire based advancement of a rotation assembly
US8277502B2 (en) 2009-10-29 2012-10-02 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
AU2010311811B2 (en) 2009-11-02 2015-09-17 Symetis Sa Aortic bioprosthesis and systems for delivery thereof
GR1007028B (el) 2009-11-11 2010-10-22 Ευσταθιος-Ανδρεας Αγαθος Υποστηρικτης βιοπροσθετικων βαλβιδων με διαγλωχινικο συνδεσμο σχηματος καρδιας
DE102009055969A1 (de) 2009-11-27 2011-06-01 Transcatheter Technologies Gmbh Vorrichtung und Set zum Falten oder Entfalten eines medizinischen Implantats und Verfahren
US8734467B2 (en) 2009-12-02 2014-05-27 Valtech Cardio, Ltd. Delivery tool for implantation of spool assembly coupled to a helical anchor
US8449599B2 (en) 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
EP3300695B1 (en) 2009-12-08 2023-05-24 Avalon Medical Ltd. Device and system for transcatheter mitral valve replacement
WO2011084500A2 (en) 2009-12-15 2011-07-14 Edwards Lifesciences Corporation Expansion device for treatment of vascular passageways
CA2784126C (en) 2009-12-18 2018-11-06 Vysera Biomedical Limited Biomaterials comprising polybutadiene-polyalkyletherpolysiloxane tri-block copolymers
US8869982B2 (en) 2009-12-18 2014-10-28 Edwards Lifesciences Corporation Prosthetic heart valve packaging and deployment system
US20110146361A1 (en) 2009-12-22 2011-06-23 Edwards Lifesciences Corporation Method of Peening Metal Heart Valve Stents
CN102113921A (zh) 2009-12-30 2011-07-06 微创医疗器械(上海)有限公司 一种介入式心脏瓣膜
US20110160838A1 (en) 2009-12-31 2011-06-30 Blanzy Jeffrey S Endoprosthesis containing multi-phase ferrous steel
US9504562B2 (en) 2010-01-12 2016-11-29 Valve Medical Ltd. Self-assembling modular percutaneous valve and methods of folding, assembly and delivery
US8449608B2 (en) 2010-01-22 2013-05-28 Edwards Lifesciences Corporation Tricuspid ring
EP2351540A1 (en) 2010-01-27 2011-08-03 Jönsson, Anders Device and method for reducing cardiac valve regurgitation
US9107749B2 (en) 2010-02-03 2015-08-18 Edwards Lifesciences Corporation Methods for treating a heart
EP2531143B1 (en) 2010-02-03 2018-01-17 Medtronic GBI, Inc. Semi-flexible annuloplasty ring
US20110190697A1 (en) 2010-02-03 2011-08-04 Circulite, Inc. Vascular introducers having an expandable section
US8839957B2 (en) 2010-02-15 2014-09-23 Michael C. Murad Prosthetic heart valve packaging system
US8926693B2 (en) 2010-02-17 2015-01-06 Medtronic, Inc. Heart valve delivery catheter with safety button
US8292948B2 (en) 2010-02-17 2012-10-23 Medtronic Vascular, Inc. Apparatus and methods for creating a venous valve from autologous tissue
DE102010008362A1 (de) 2010-02-17 2011-08-18 Transcatheter Technologies GmbH, 93053 Medizinisches Implantat, welches aus einem nicht expandierten Zustand expandierbar ist
DE102010008360A1 (de) 2010-02-17 2011-09-29 Transcatheter Technologies Gmbh Medizinisches Implantat, in welchem beim Crimpen bzw. Falten Lücken verbleiben, Verfahren und Einrichtung zum Verbringen
US8518106B2 (en) 2010-02-17 2013-08-27 Medtronic, Inc. Catheter assembly with valve crimping accessories
DE102010008382A1 (de) 2010-02-17 2011-08-18 Transcatheter Technologies GmbH, 93053 Verfahren zum Crimpen bzw. Falten eines medizinischen Implantats an einer Einrichtung zum Verbringen oder Einführen desselben unter Einsatz von Zero-Pressure-Crimping sowie Einrichtungen
US8475523B2 (en) 2010-02-17 2013-07-02 Medtronic, Inc. Distal tip assembly for a heart valve delivery catheter
DE102010008338A1 (de) 2010-02-17 2011-08-18 Transcatheter Technologies GmbH, 93053 Einrichtung, vorgesehen, um an einem Katheter befestigt oder mit diesem verbunden zu werden, Katheter und Verfahren
US20110208293A1 (en) 2010-02-23 2011-08-25 Medtronic, Inc. Catheter-Based Heart Valve Therapy System with Sizing Balloon
US9072603B2 (en) 2010-02-24 2015-07-07 Medtronic Ventor Technologies, Ltd. Mitral prosthesis and methods for implantation
US9414914B2 (en) 2010-02-24 2016-08-16 Medtronic Ventor Technologies Ltd. Catheter assembly with valve crimping accessories
US9522062B2 (en) 2010-02-24 2016-12-20 Medtronic Ventor Technologies, Ltd. Mitral prosthesis and methods for implantation
US9226826B2 (en) 2010-02-24 2016-01-05 Medtronic, Inc. Transcatheter valve structure and methods for valve delivery
EP2538878B1 (en) 2010-02-25 2021-11-24 JenaValve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
WO2011109450A2 (en) 2010-03-01 2011-09-09 Colibri Heart Valve Llc Percutaneously deliverable heart valve and methods associated therewith
US8795354B2 (en) 2010-03-05 2014-08-05 Edwards Lifesciences Corporation Low-profile heart valve and delivery system
US8679404B2 (en) 2010-03-05 2014-03-25 Edwards Lifesciences Corporation Dry prosthetic heart valve packaging system
CN102869321B (zh) 2010-03-05 2015-05-06 爱德华兹生命科学公司 人工瓣膜锁紧机构
ES2365317B1 (es) 2010-03-19 2012-08-03 Xavier Ruyra Baliarda Banda protésica, en particular para la reparación de una válvula mitral.
EP3636293A1 (en) 2010-03-23 2020-04-15 Edwards Lifesciences Corporation Methods of conditioning sheet bioprosthetic tissue
JP2013521977A (ja) 2010-03-23 2013-06-13 ボストン サイエンティフィック サイムド，インコーポレイテッド 弁輪形成装置
DE102010012677B4 (de) 2010-03-24 2017-08-10 Fehling Instruments Gmbh & Co. Kg Spreizer für die Aortenklappenrekonstruktion
US9480557B2 (en) 2010-03-25 2016-11-01 Medtronic, Inc. Stents for prosthetic heart valves
SE535140C2 (sv) 2010-03-25 2012-04-24 Jan Otto Solem En implanterbar anordning, kit och system för förbättring av hjärtfunktionen, innefattande medel för generering av longitudinell rörelse av mitralisklaffen
SE535690C2 (sv) 2010-03-25 2012-11-13 Jan Otto Solem En implanterbar anordning och kit för hjärtunderstöd, innefattande medel för generering av longitudinell rörelse av mitralisklaffen
EP2552356B1 (en) 2010-03-26 2019-03-13 Thubrikar Aortic Valve Inc. Valve component, frame component and prosthetic valve device including the same for implantation in a body lumen
US9320597B2 (en) 2010-03-30 2016-04-26 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with recapturing feature and method
US8512400B2 (en) 2010-04-09 2013-08-20 Medtronic, Inc. Transcatheter heart valve delivery system with reduced area moment of inertia
US8998980B2 (en) 2010-04-09 2015-04-07 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with recapturing feature and method
US8512401B2 (en) 2010-04-12 2013-08-20 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with funnel recapturing feature and method
US8579963B2 (en) 2010-04-13 2013-11-12 Medtronic, Inc. Transcatheter prosthetic heart valve delivery device with stability tube and method
US8357195B2 (en) 2010-04-15 2013-01-22 Medtronic, Inc. Catheter based annuloplasty system and method
US10512537B2 (en) 2010-04-16 2019-12-24 Abiomed, Inc. Flow optimized polymeric heart valve
US9833314B2 (en) 2010-04-16 2017-12-05 Abiomed, Inc. Percutaneous valve deployment
US8465541B2 (en) 2010-04-19 2013-06-18 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system and method with expandable stability tube
US8764811B2 (en) 2010-04-20 2014-07-01 Medtronic Vascular, Inc. Controlled tip release stent graft delivery system and method
US8876892B2 (en) 2010-04-21 2014-11-04 Medtronic, Inc. Prosthetic heart valve delivery system with spacing
US8740976B2 (en) 2010-04-21 2014-06-03 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with flush report
US8623075B2 (en) 2010-04-21 2014-01-07 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system and method with controlled expansion of prosthetic heart valve
EP4494608A3 (en) 2010-04-21 2025-04-02 Medtronic, Inc. Prosthetic valve with sealing members
US9629719B2 (en) 2010-04-23 2017-04-25 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
US8568474B2 (en) 2010-04-26 2013-10-29 Medtronic, Inc. Transcatheter prosthetic heart valve post-dilatation remodeling devices and methods
AU2011248658B2 (en) 2010-04-27 2014-09-11 Medtronic Inc. Transcatheter prosthetic heart valve delivery device with biased release features
WO2011139746A1 (en) 2010-04-27 2011-11-10 Medtronic Inc. Transcatheter prosthetic heart valve delivery device with passive trigger release
CA2991641C (en) 2010-04-29 2020-12-15 Vinay Badhwar Automatic suturing apparatus and methods of use
US8974475B2 (en) 2010-04-30 2015-03-10 Medtronic, Inc. Methods and devices for cardiac valve repair or replacement
US8986374B2 (en) 2010-05-10 2015-03-24 Edwards Lifesciences Corporation Prosthetic heart valve
US9554901B2 (en) 2010-05-12 2017-01-31 Edwards Lifesciences Corporation Low gradient prosthetic heart valve
US9433501B2 (en) 2010-05-19 2016-09-06 Direct Flow Medical, Inc. Inflation media for implants
SI2387977T1 (sl) 2010-05-20 2014-03-31 Jenavalve Technology Inc. Regus Business Centre Wilmington Downtown Katetrski sistem za vstavljanje razteznega stenta srčne zaklopke v telo pacienta
US10856978B2 (en) 2010-05-20 2020-12-08 Jenavalve Technology, Inc. Catheter system
IT1400327B1 (it) 2010-05-21 2013-05-24 Sorin Biomedica Cardio Srl Dispositivo di supporto per protesi valvolari e corrispondente corredo.
US8790394B2 (en) 2010-05-24 2014-07-29 Valtech Cardio, Ltd. Adjustable artificial chordeae tendineae with suture loops
CN103002833B (zh) 2010-05-25 2016-05-11 耶拿阀门科技公司 人工心脏瓣及包括人工心脏瓣和支架的经导管输送的内假体
WO2011148299A1 (en) 2010-05-27 2011-12-01 Koninklijke Philips Electronics N.V. Determining the specific orientation of an object
US9387077B2 (en) 2010-05-27 2016-07-12 Medtronic Vascular Galway Catheter assembly with prosthesis crimping and prosthesis retaining accessories
US9561102B2 (en) 2010-06-02 2017-02-07 Medtronic, Inc. Transcatheter delivery system and method with controlled expansion and contraction of prosthetic heart valve
EP3061422B1 (en) 2010-06-21 2021-11-03 Edwards Lifesciences CardiAQ LLC Replacement heart valve
JP5833832B2 (ja) 2010-06-30 2015-12-16 テルモ株式会社 生体移植片移送器具及び生体移植片の移送方法
EP2962664B1 (en) 2010-07-09 2022-05-11 Highlife SAS Transcatheter atrio-ventricular valve prosthesis
US9592119B2 (en) 2010-07-13 2017-03-14 C.R. Bard, Inc. Inflatable medical devices
US9119717B2 (en) 2010-07-15 2015-09-01 St. Jude Medical, Inc. Retainers for transcatheter heart valve delivery systems
US8992604B2 (en) 2010-07-21 2015-03-31 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
EP2598044B1 (en) 2010-07-27 2019-03-13 Incept, LLC Apparatus for treating neurovascular venous outflow obstruction
ES2471367T3 (es) 2010-07-30 2014-06-26 Institut Quimic De Sarria Implante bioactivo
EP2600798B1 (en) 2010-08-03 2015-10-28 Cook Medical Technologies LLC Two valve caval stent for functional replacement of incompetent tricuspid valve
US8518107B2 (en) 2010-08-04 2013-08-27 Valcare, Inc. Percutaneous transcatheter repair of heart valves
WO2012023978A2 (en) 2010-08-17 2012-02-23 St. Jude Medical, Inc. Delivery system for collapsible heart valve
WO2012023981A2 (en) 2010-08-17 2012-02-23 St. Jude Medical, Inc. Tip for medical implant delivery system
CA2808830A1 (en) 2010-08-23 2012-03-01 Edwards Lifesciences Corporation Color-coded prosthetic valve system and methods for using the same
WO2012027515A2 (en) 2010-08-24 2012-03-01 Southern Lights Ventures 2002 Limited Biomaterials with enhanced properties and devices made therefrom
JP5891228B2 (ja) 2010-08-24 2016-03-22 セント・ジュード・メディカル，インコーポレイテッド 経カテーテル心臓弁送達システム用の段階的展開装置および方法
CA2808885C (en) 2010-08-24 2017-01-10 John F. Migliazza Flexible annuloplasty ring with select control points
US9039759B2 (en) 2010-08-24 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Repositioning of prosthetic heart valve and deployment
WO2012030370A1 (en) 2010-08-31 2012-03-08 Edwards Lifesciences Corporation Physiologic tricuspid annuloplasty ring
EP2422748B1 (de) 2010-08-31 2016-01-27 Biotronik AG Medizinisches Implantat, insbesondere Klappenimplantat, zur Implantation in einen tierischen und/oder menschlichen Körper sowie Verfahren, insbesondere Herstellungsverfahren, zur Herstellung einer Implantationsvorrichtung für das medizinische Implantat
EP2611391B1 (en) 2010-09-01 2017-11-22 Mvalve Technologies Ltd. Cardiac valve support structure
WO2012030598A2 (en) 2010-09-01 2012-03-08 Medtronic Vascular Galway Limited Prosthetic valve support structure
AU2011300644B2 (en) 2010-09-10 2015-08-20 Symetis Sa Valve replacement devices and a system comprising the valve replacement device and a delivery device therefor
US8641757B2 (en) 2010-09-10 2014-02-04 Edwards Lifesciences Corporation Systems for rapidly deploying surgical heart valves
US10076327B2 (en) 2010-09-14 2018-09-18 Evalve, Inc. Flexible actuator mandrel for tissue apposition systems
DE102010037529A1 (de) 2010-09-14 2012-03-15 Transcatheter Technologies Gmbh Einrichtung, vorgesehen, um an einem Katheter befestigt oder mit diesem verbunden zu werden, Katheter und Verfahren
FR2964855B1 (fr) 2010-09-17 2013-10-18 Ct Hospitalier Regional Universitaire D Amiens Implant destine a etre place dans un passage sanguin auriculo-ventriculaire
WO2012036742A2 (en) 2010-09-17 2012-03-22 St. Jude Medical, Cardiology Division, Inc. Assembly and method for loading a self-expanding collapsible heart valve
WO2012036741A2 (en) 2010-09-17 2012-03-22 St. Jude Medical, Cardiology Division, Inc. Staged deployment devices and methods for transcatheter heart valve delivery
WO2012036740A2 (en) 2010-09-17 2012-03-22 St. Jude Medical, Cardiology Division, Inc. Retainers for transcatheter heart valve delivery systems
US10603166B2 (en) 2010-09-20 2020-03-31 St. Jude Medical, Cardiology Division, Inc. Delivery device having a curved shaft and a straightening member for transcatheter aortic valve implantation
US9011527B2 (en) 2010-09-20 2015-04-21 St. Jude Medical, Cardiology Division, Inc. Valve leaflet attachment in collapsible prosthetic valves
CN103118630B (zh) 2010-09-24 2016-05-04 西美蒂斯股份公司 支架瓣膜、输送设备和输送方法
US8845720B2 (en) 2010-09-27 2014-09-30 Edwards Lifesciences Corporation Prosthetic heart valve frame with flexible commissures
JP5592016B2 (ja) 2010-09-29 2014-09-17 タウピーエヌユーメディカル シーオー．，エルティーディー． 冠状静脈洞及び三尖弁膜の組織保護器具
ES2583629T3 (es) 2010-09-30 2016-09-21 Biostable Science&Engineering Inc. Dispositivos de válvula aórtica
EP2621407B1 (en) 2010-09-30 2018-01-17 Biostable Science & Engineering, Inc. Intra-annular mounting frame for aortic valve repair
PL3593762T3 (pl) 2010-10-05 2021-05-04 Edwards Lifesciences Corporation Zastawka protetyczna serca i urządzenie do wprowadzania
EP2629699B1 (en) 2010-10-21 2017-01-04 Medtronic, Inc. Mitral bioprosthesis with low ventricular profile
GB201017921D0 (en) 2010-10-22 2010-12-01 Ucl Business Plc Prothesis delivery system
US8562663B2 (en) 2010-10-26 2013-10-22 Medtronic Ventor Technologies Ltd. Devices and methods for loading a prosthesis onto a delivery system
US20120116496A1 (en) 2010-11-05 2012-05-10 Chuter Timothy A Stent structures for use with valve replacements
US20120116498A1 (en) 2010-11-05 2012-05-10 Chuter Timothy A Aortic valve prostheses
IT1402571B1 (it) 2010-11-12 2013-09-13 Ht Consultant Di Giovanni Righini Sistema protesico per valvola cardio-vascolare con struttura di ancoraggio separata
US9351829B2 (en) 2010-11-17 2016-05-31 Edwards Lifesciences Corporation Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability
DE102010051632B4 (de) 2010-11-17 2013-09-12 Hans-Hinrich Sievers Gestentete biologische Herzklappe
EP2640316B1 (en) 2010-11-18 2017-03-15 Pavilion Medical Innovations, LLC Tissue restraining devices and methods of use
US9078750B2 (en) 2010-11-30 2015-07-14 Edwards Lifesciences Corporation Ergonomic mitral heart valve holders
US8932350B2 (en) 2010-11-30 2015-01-13 Edwards Lifesciences Corporation Reduced dehiscence annuloplasty ring
WO2012079736A1 (en) 2010-12-14 2012-06-21 Wolfgang Goetz Apparatus comprising an aligning device, set and method
US9579197B2 (en) 2010-12-15 2017-02-28 Medtronic Vascular, Inc. Systems and methods for positioning a heart valve using visual markers
DE102010061371A1 (de) 2010-12-20 2012-06-21 Transcatheter Technologies Gmbh Vorrichtung mit individuellen Schaftfasern und Set zum Falten oder Entfalten eines medizinischen Implantats und Verfahren
EP2468215A1 (en) 2010-12-22 2012-06-27 Centre Hospitaller Universitaire Vaudois (CHUV) Annuloplasty ring
US9044221B2 (en) 2010-12-29 2015-06-02 Neochord, Inc. Exchangeable system for minimally invasive beating heart repair of heart valve leaflets
AU2012204392B2 (en) 2011-01-04 2015-06-11 The Cleveland Clinic Foundation Apparatus and method for treating a regurgitant heart valve
US8948848B2 (en) 2011-01-07 2015-02-03 Innovative Cardiovascular Solutions, Llc Angiography catheter
EP2663355B1 (en) 2011-01-11 2019-08-28 Symetis SA Apparatus useful for transcatheter aortic valve implantation
WO2012095116A1 (de) 2011-01-11 2012-07-19 Hans Reiner Figulla Klappenprothese zum ersatz einer atrioventricularklappe des herzens
EP2474287A1 (en) 2011-01-11 2012-07-11 Symetis Sa Delivery catheter for stent-valve, and sub-assembly therefor
AU2012207362B2 (en) 2011-01-18 2016-07-14 Loma Vista Medical, Inc. Inflatable medical devices
DE102011009555A1 (de) 2011-01-21 2012-07-26 Aesculap Ag Gefäßprothese mit integrierter Aortenklappe
US8845717B2 (en) 2011-01-28 2014-09-30 Middle Park Medical, Inc. Coaptation enhancement implant, system, and method
EP2670356B1 (en) 2011-01-31 2016-09-28 St. Jude Medical, Inc. Adjustable prosthetic anatomical device holder and handle for the implantation of an annuloplasty ring
EP2670354B1 (en) 2011-01-31 2016-04-27 St. Jude Medical, Inc. Adjustable annuloplasty ring sizing indicator
US9622860B2 (en) 2011-01-31 2017-04-18 St. Jude Medical, Inc. Anti-rotation locking feature
WO2012106351A1 (en) 2011-01-31 2012-08-09 St. Jude Medical, Inc. Tool for the adjustment of a prosthetic anatomical device
US9314336B2 (en) 2011-01-31 2016-04-19 St. Jude Medical, Inc. Adjustment assembly for an adjustable prosthetic valve device
US9717593B2 (en) 2011-02-01 2017-08-01 St. Jude Medical, Cardiology Division, Inc. Leaflet suturing to commissure points for prosthetic heart valve
EP2484309B1 (en) 2011-02-02 2019-04-10 Shlomo Gabbay Heart valve prosthesis
US9021674B2 (en) 2011-02-02 2015-05-05 St. Jude Medical, Inc. System for loading a collapsible heart valve
AU2012214279A1 (en) 2011-02-10 2013-08-22 Corvia Medical, Inc. Apparatus and methods to create and maintain an intra-atrial pressure relief opening
US20120209375A1 (en) 2011-02-11 2012-08-16 Gilbert Madrid Stability device for use with percutaneous delivery systems
EP2486894B1 (en) 2011-02-14 2021-06-09 Sorin Group Italia S.r.l. Sutureless anchoring device for cardiac valve prostheses
EP2486893B1 (en) 2011-02-14 2017-07-05 Sorin Group Italia S.r.l. Sutureless anchoring device for cardiac valve prostheses
CN103429193B (zh) 2011-02-15 2015-09-16 梅迪瓦尔夫有限公司 经皮定位装置
GB2488530A (en) 2011-02-18 2012-09-05 David J Wheatley Heart valve
JP5575277B2 (ja) 2011-02-18 2014-08-20 株式会社パイオラックスメディカルデバイス 腹腔−静脈シャント用ステント
US9155619B2 (en) 2011-02-25 2015-10-13 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
US9232996B2 (en) 2011-02-25 2016-01-12 University Of Connecticut Prosthetic heart valve
PL218575B1 (pl) 2011-02-28 2014-12-31 Fundacja Rozwoju Kardiochirurgii Im Prof Zbigniewa Religi Sposób wytwarzania warstw powierzchniowych na implantach medycznych
US9445898B2 (en) 2011-03-01 2016-09-20 Medtronic Ventor Technologies Ltd. Mitral valve repair
US20120226340A1 (en) 2011-03-03 2012-09-06 Empire Technology Development, Llc Temporary perfusion channel for percutaneous delivery of balloon-expandable stents
EP4119095A1 (en) 2011-03-21 2023-01-18 Cephea Valve Technologies, Inc. Disk-based valve apparatus
EP3536282A1 (en) 2011-03-23 2019-09-11 Daidalos Solutions B.V. Medical instrument, ring prosthesis, stent and stented valve
US10016461B2 (en) 2012-12-03 2018-07-10 The Regents Of The University Of California Apparatus and process for growing a heart valve in three-dimensions
WO2012127475A1 (en) 2011-03-24 2012-09-27 Neurim Pharmaceuticals (1991) Ltd. Neuroprotective peptides
US11213393B2 (en) 2011-04-01 2022-01-04 Edwards Lifesciences Corporation Compressible heart valve annulus sizing templates
US8961599B2 (en) 2011-04-01 2015-02-24 W. L. Gore & Associates, Inc. Durable high strength polymer composite suitable for implant and articles produced therefrom
US8945212B2 (en) 2011-04-01 2015-02-03 W. L. Gore & Associates, Inc. Durable multi-layer high strength polymer composite suitable for implant and articles produced therefrom
EP2693985B1 (en) 2011-04-04 2020-07-29 The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center Device for heart valve repair
EP2699169B1 (en) 2011-04-20 2018-02-14 The Board of Trustees of The Leland Stanford Junior University Systems for endoluminal valve creation
US9381082B2 (en) 2011-04-22 2016-07-05 Edwards Lifesciences Corporation Devices, systems and methods for accurate positioning of a prosthetic valve
EP2520250B1 (en) 2011-05-04 2014-02-19 Medtentia International Ltd Oy Medical device for a cardiac valve implant
EP2520251A1 (en) 2011-05-05 2012-11-07 Symetis SA Method and Apparatus for Compressing Stent-Valves
EP2522307B1 (en) 2011-05-08 2020-09-30 ITSO Medical AB Device for delivery of medical devices to a cardiac valve
EP2522308B1 (de) 2011-05-10 2015-02-25 Biotronik AG Mechanische Transkatheter-Herzklappenprothese
US9144494B2 (en) 2011-05-12 2015-09-29 Medtronic, Inc. Delivery catheter system with micro and macro movement control
US9486604B2 (en) 2011-05-12 2016-11-08 Medtronic, Inc. Packaging and preparation tray for a delivery system
US9492600B2 (en) 2011-05-13 2016-11-15 Heartware, Inc. Intravascular blood pump and method of implantation
EP2709561B1 (en) 2011-05-16 2018-04-25 Hlt, Inc. Inversion delivery device and method for a prosthesis
US8814932B2 (en) 2011-05-17 2014-08-26 Boston Scientific Scimed, Inc. Annuloplasty ring with piercing wire and segmented wire lumen
WO2012158189A1 (en) 2011-05-17 2012-11-22 Boston Scientific Scimed, Inc. Annuloplasty ring with anchors fixed by curing polymer
US8945209B2 (en) 2011-05-20 2015-02-03 Edwards Lifesciences Corporation Encapsulated heart valve
ES2841108T3 (es) 2011-05-26 2021-07-07 On X Life Tech Inc Manguito de costura de válvula cardíaca
US8696744B2 (en) 2011-05-27 2014-04-15 Cormatrix Cardiovascular, Inc. Extracellular matrix material valve conduit and methods of making thereof
WO2012167120A2 (en) 2011-06-01 2012-12-06 Neochord, Inc. Minimally invasive repair of heart valve leaflets
ES2586532T3 (es) 2011-06-01 2016-10-17 Nvt Ag Sistema de despliegue de prótesis de válvula cardiaca
US9402721B2 (en) 2011-06-01 2016-08-02 Valcare, Inc. Percutaneous transcatheter repair of heart valves via trans-apical access
US20120315260A1 (en) 2011-06-13 2012-12-13 Svetlana A. Ivanova Compositions and Methods to Prevent and Treat Biofilms
US9101471B2 (en) 2011-06-13 2015-08-11 Edwards Lifesciences Corporation Systems and delivery handles for delivering prosthetic heart valves disposed on valve holders
US8840664B2 (en) 2011-06-15 2014-09-23 Edwards Lifesciences Corporation Heart valve prosthesis anchoring device and methods
US20140220280A1 (en) 2011-06-20 2014-08-07 Essel Propack Ltd. Process of recycling plastics, products and applications thereof
CA2840084C (en) 2011-06-21 2019-11-05 Foundry Newco Xii, Inc. Prosthetic heart valve devices and associated systems and methods
EP2723274B1 (en) 2011-06-23 2017-12-27 Valtech Cardio, Ltd. Closure element for use with annuloplasty structure
EP3395298B1 (en) 2011-06-27 2024-12-18 University of Maryland, Baltimore Transapical mitral valve repair device
US9364326B2 (en) 2011-06-29 2016-06-14 Mitralix Ltd. Heart valve repair devices and methods
US9358107B2 (en) 2011-06-30 2016-06-07 Edwards Lifesciences Corporation Systems, dies, and methods for processing pericardial tissue
US8926588B2 (en) 2011-07-05 2015-01-06 Medtronic Vascular, Inc. Steerable delivery catheter
DE102011106928B4 (de) 2011-07-08 2019-02-07 Admedes Schuessler Gmbh Verfahren, Vorrichtung und Verwendung eines Verfahrens zum elektrochemischen Abtragen eines Werkstoffs
DE102011107551B4 (de) 2011-07-11 2015-05-28 Universitätsklinikum Schleswig-Holstein Anuloplastiering
JP2014527425A (ja) 2011-07-12 2014-10-16 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 医療機器用の連結システム
US8795357B2 (en) 2011-07-15 2014-08-05 Edwards Lifesciences Corporation Perivalvular sealing for transcatheter heart valve
EP3424468A1 (en) 2011-07-21 2019-01-09 4Tech Inc. Apparatus for tricuspid valve repair using tension
US9119716B2 (en) 2011-07-27 2015-09-01 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
US8931159B2 (en) 2011-07-28 2015-01-13 St. Jude Medical, Cardiology Division, Inc. System for loading a collapsible heart valve
US8893370B2 (en) 2011-07-28 2014-11-25 St. Jude Medical, Cardiology Division, Inc. System for loading a collapsible heart valve
GB201113060D0 (en) 2011-07-29 2011-09-14 Univ Ulster Tissue scaffold
WO2013019756A2 (en) 2011-07-29 2013-02-07 Carnegie Mellon University Artificial valved conduits for cardiac reconstructive procedures and methods for their production
WO2013021375A2 (en) 2011-08-05 2013-02-14 Mitraltech Ltd. Percutaneous mitral valve replacement and sealing
EP2554139A1 (en) 2011-08-05 2013-02-06 Centre Hospitalier Universitaire Vaudois Actuating device for a surgical implant
WO2013022798A1 (en) 2011-08-05 2013-02-14 California Institute Of Technology Percutaneous heart valve delivery systems
US9872770B2 (en) 2011-08-11 2018-01-23 St. Jude Medical, Inc. Apparatus and method for heart valve repair
EP2741711B1 (en) 2011-08-11 2018-05-30 Tendyne Holdings, Inc. Improvements for prosthetic valves and related inventions
US9060860B2 (en) 2011-08-18 2015-06-23 St. Jude Medical, Cardiology Division, Inc. Devices and methods for transcatheter heart valve delivery
EP2564811B1 (en) 2011-08-31 2021-03-10 The Cleveland Clinic Foundation Delivery system for an endoluminal device
EP2564812B1 (en) 2011-08-31 2018-12-19 Cook Medical Technologies LLC Delivery system for an endoluminal prosthesis
WO2013035864A1 (ja) 2011-09-09 2013-03-14 新幹工業株式会社 弁付きステント、弁付きステント形成用基材、及び弁付きステントの生産方法
DE102014102725A1 (de) 2014-02-28 2015-09-17 Highlife Sas Transkatheter-Klappenprothese
WO2013037805A1 (en) 2011-09-12 2013-03-21 Highlife Sas Treatment catheter system
DE102011054176B4 (de) 2011-09-12 2016-02-04 Highlife Sas Behandlungs-Katheter-System
EP2755602B1 (en) 2011-09-12 2017-08-09 Highlife SAS Transcatheter valve prosthesis
DE102014102653A1 (de) 2014-02-28 2015-09-03 Highlife Sas Transkatheter-Klappenprothese
US9011468B2 (en) 2011-09-13 2015-04-21 Abbott Cardiovascular Systems Inc. Independent gripper
US8945177B2 (en) 2011-09-13 2015-02-03 Abbott Cardiovascular Systems Inc. Gripper pusher mechanism for tissue apposition systems
US8920493B2 (en) 2011-09-16 2014-12-30 St. Jude Medical, Cardiology Division, Inc. Systems and methods for holding annuloplasty rings
US9422615B2 (en) 2011-09-16 2016-08-23 W. L. Gore & Associates, Inc. Single step shape memory alloy expansion
EP2572684B1 (de) 2011-09-23 2016-05-04 Biotronik AG Freigabevorrichtung zum Lösen eines medizinischen Implantats von einem Katheter sowie Katheter mit einer Freigabevorrichtung
US8900295B2 (en) 2011-09-26 2014-12-02 Edwards Lifesciences Corporation Prosthetic valve with ventricular tethers
US9554904B2 (en) 2011-09-28 2017-01-31 Medtronic CV Luxembourg S.a.r.l. Distal tip assembly for a heart valve delivery catheter
EP3175797B1 (en) 2011-09-30 2020-02-12 Bioventrix, Inc. Trans-catheter ventricular reconstruction structures and systems for treatment of congestive heart failure and other conditions
WO2013052757A2 (en) 2011-10-05 2013-04-11 Boston Scientific Scimed, Inc. Profile reduction seal
FR2980968B1 (fr) 2011-10-10 2013-12-27 Assist Publ Hopitaux De Paris Prothese cardiovasculaire en polymere biodegradable comprenant un element tubulaire logeant une valve et procede de fabrication de ladite prothese
US9655720B2 (en) 2011-10-13 2017-05-23 The Research Foundation For The State University Of New York Polymeric heart valve
ES2372949B1 (es) 2011-10-14 2012-10-04 Accesorios Y Elevadores Valencia, S.L. Sistema para unir un dispositivo elevador al soporte de suspensión de un vehículo.
JP6151705B2 (ja) 2011-10-19 2017-06-21 トゥエルヴ， インコーポレイテッド 心臓弁置換のためのデバイス、システムおよび方法
EA201400481A1 (ru) 2011-10-19 2014-10-30 Твелв, Инк. Искусственные сердечно-клапанные устройства, искусственные митральные клапаны и соответствующие системы и способы
US9827093B2 (en) 2011-10-21 2017-11-28 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
US8945146B2 (en) 2011-10-24 2015-02-03 Medtronic, Inc. Delivery system assemblies and associated methods for implantable medical devices
CN102423505B (zh) 2011-10-27 2014-12-10 上海微创医疗器械（集团）有限公司 膜式渗透汽化式固定人工生物瓣的方法及装置
US9192496B2 (en) 2011-10-31 2015-11-24 Merit Medical Systems, Inc. Systems and methods for sheathing an implantable device
US8986368B2 (en) 2011-10-31 2015-03-24 Merit Medical Systems, Inc. Esophageal stent with valve
CA3082091C (en) 2011-11-10 2023-01-31 Transaortic Medical, Inc. System for deploying a device to a distal location across a diseased vessel
US9131926B2 (en) 2011-11-10 2015-09-15 Boston Scientific Scimed, Inc. Direct connect flush system
EP2591754B1 (en) 2011-11-10 2015-02-25 Medtentia International Ltd Oy A device and a method for improving the function of a heart valve
EP2591755A1 (en) 2011-11-12 2013-05-15 Medtentia International Ltd Oy Device and method for improving fixation of a medical device
US8851286B2 (en) 2011-11-15 2014-10-07 Boston Scientific Scimed Inc. Dual sterilization containment vessel
EP2779945B1 (en) 2011-11-15 2021-07-14 Boston Scientific Scimed, Inc. Medical device with keyed locking structures
US8721587B2 (en) 2011-11-17 2014-05-13 Medtronic, Inc. Delivery system assemblies and associated methods for implantable medical devices
FR2982763B1 (fr) 2011-11-17 2015-07-17 Ct Hospitalier Regional Universitaire D Amiens Implant destine a etre place dans un passage de circulation du sang et dispositif de traitement associe
US8951243B2 (en) 2011-12-03 2015-02-10 Boston Scientific Scimed, Inc. Medical device handle
US9480558B2 (en) 2011-12-05 2016-11-01 Medtronic, Inc. Transcatheter valve having reduced seam exposure
WO2013086132A1 (en) 2011-12-06 2013-06-13 Aortic Innovations Llc Device for endovascular aortic repair and method of using the same
US9345574B2 (en) 2011-12-09 2016-05-24 Edwards Lifesciences Corporation Force-based heart valve sizer
PL2787926T3 (pl) 2011-12-09 2022-11-14 Edwards Lifesciences Corporation Usprawnione wsporniki spojeń zastawki protetycznej serca
CN104203157B (zh) 2011-12-12 2016-02-03 戴维·阿隆 心脏瓣膜修补器械
JP2015503948A (ja) 2011-12-13 2015-02-05 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 脱灰機能を備えた心臓弁
US9078645B2 (en) 2011-12-19 2015-07-14 Edwards Lifesciences Corporation Knotless suture anchoring devices and tools for implants
US9277993B2 (en) 2011-12-20 2016-03-08 Boston Scientific Scimed, Inc. Medical device delivery systems
CA2860225A1 (en) 2011-12-20 2013-06-27 Boston Scientific Scimed, Inc. Apparatus for endovascularly replacing a heart valve
US9510945B2 (en) 2011-12-20 2016-12-06 Boston Scientific Scimed Inc. Medical device handle
EP3581152B1 (en) 2011-12-21 2025-09-24 Majoro Cardiac Innovations, LLC Platforms for mitral valve replacement
US9078747B2 (en) 2011-12-21 2015-07-14 Edwards Lifesciences Corporation Anchoring device for replacing or repairing a heart valve
AU2012268911B2 (en) 2011-12-22 2014-04-24 Cook Medical Technologies Llc Endoluminal prosthesis comprising a valve replacement and at least one fenestration
EP2793743B1 (en) 2011-12-23 2020-11-04 MyoPowers Medical Technologies France SAS Medical device comprising an artificial contractile structure
EP2609893B1 (en) 2011-12-29 2014-09-03 Sorin Group Italia S.r.l. A kit for implanting prosthetic vascular conduits
EP2609894B1 (en) 2011-12-31 2015-04-01 Fundacja Rozwoju Kardiochirurgii Im. Prof. Zbigniewa Religi Heart valve
US9492265B2 (en) 2012-01-06 2016-11-15 Emboline, Inc. Integrated embolic protection devices
EP2802290B1 (en) 2012-01-10 2018-07-11 Jenesis Surgical, LLC Articulated support structure with secondary strut features
CN102556433B (zh) 2012-01-16 2014-06-11 石家庄成功机电有限公司 单缸单爪双卡打卡机
EP2620125B1 (en) 2012-01-24 2017-10-11 Medtentia International Ltd Oy An arrangement, a loop-shaped support, a prosthetic heart valve and a method of repairing or replacing a native heart valve
US9610082B2 (en) 2012-01-25 2017-04-04 St. Jude Medical, Inc. Apparatus and method for heart valve repair
FR2986149B1 (fr) 2012-01-26 2014-12-26 Ct Hospitalier Universitaire De Clermont Fd Dispositif de remplacement d'au moins un cordage de la valve mitrale et kit comprenant au moins deux dispositifs
US9226812B2 (en) 2012-01-30 2016-01-05 Kawasumi Laboratories, Inc. Biliary stent
EP2809263B1 (en) 2012-01-31 2017-08-23 Mitral Valve Technologies Sàrl Mitral valve docking devices, systems
ES2597754T3 (es) 2012-02-01 2017-01-20 St. Jude Medical, Inc. Sistema de administración de sujetador para reparación de válvula cardiaca y método de uso
EP2809272B1 (en) 2012-02-01 2017-01-04 Hlt, Inc. Invertible tissue valve
US10058348B2 (en) 2012-02-02 2018-08-28 St. Jude Medical, Cardiology Division, Inc. Apparatus and method for heart valve repair
WO2013119849A1 (en) 2012-02-07 2013-08-15 Intervene, Inc. Systems and methods for endoluminal valve creation
WO2013120082A1 (en) 2012-02-10 2013-08-15 Kassab Ghassan S Methods and uses of biological tissues for various stent and other medical applications
US10420645B2 (en) 2012-02-15 2019-09-24 Children's Medical Center Corporation Right ventricular papillary approximation
EP3424469A1 (en) 2012-02-22 2019-01-09 Syntheon TAVR, LLC Actively controllable stent, stent graft and heart valve
EP2819618B1 (en) 2012-02-28 2018-05-02 Mvalve Technologies Ltd. Single-ring cardiac valve support
WO2013130641A1 (en) 2012-02-29 2013-09-06 Valcare, Inc. Percutaneous annuloplasty system with anterior-posterior adjustment
BR112014022075B1 (pt) 2012-03-06 2021-05-25 Highlife Sas membro de cateter de tratamento com função envolvente
JP6001280B2 (ja) 2012-03-09 2016-10-05 学校法人金沢医科大学 心臓矯正ネットの製造方法
JP6084775B2 (ja) 2012-03-09 2017-02-22 学校法人金沢医科大学 心臓矯正ネット
US10071186B2 (en) 2012-03-12 2018-09-11 Colorado State University Research Foundation Glycosaminoglycan and synthetic polymer material for blood-contacting applications
US10292818B2 (en) 2012-03-14 2019-05-21 Universite Catholique De Louvain Device for excision of heart valve
ES2535295T3 (es) 2012-03-23 2015-05-08 Sorin Group Italia S.R.L. Prótesis de válvula plegable
US9023098B2 (en) 2012-03-28 2015-05-05 Medtronic, Inc. Dual valve prosthesis for transcatheter valve implantation
US9066800B2 (en) 2012-03-28 2015-06-30 Medtronic, Inc. Dual valve prosthesis for transcatheter valve implantation
US8926694B2 (en) 2012-03-28 2015-01-06 Medtronic Vascular Galway Limited Dual valve prosthesis for transcatheter valve implantation
US9101467B2 (en) 2012-03-30 2015-08-11 Medtronic CV Luxembourg S.a.r.l. Valve prosthesis
EP2647354B1 (en) 2012-04-04 2015-10-07 Sorin Group Italia S.r.l. A support device for heart valve prostheses
AU2013245201B2 (en) 2012-04-05 2017-10-05 Mvalve Technologies Ltd. Cardiac valve support structure
EP2836165B1 (en) 2012-04-12 2015-10-14 Medivalve Ltd. Intracorporeal imaging aid (ima)
US9999501B2 (en) 2012-04-18 2018-06-19 Medtronic CV Luxembourg S.a.r.l. Valve prosthesis
US9011515B2 (en) 2012-04-19 2015-04-21 Caisson Interventional, LLC Heart valve assembly systems and methods
CN102764169B (zh) 2012-04-19 2015-07-29 杭州启明医疗器械有限公司 人工心脏瓣膜及其瓣膜支架
US9168122B2 (en) 2012-04-26 2015-10-27 Rex Medical, L.P. Vascular device and method for valve leaflet apposition
WO2013163283A2 (en) 2012-04-27 2013-10-31 Cook Medical Technologies Llc Anti-aspiration prosthesis
EP3597741A1 (en) 2012-04-27 2020-01-22 Duke University Genetic correction of mutated genes
US9427303B2 (en) 2012-04-27 2016-08-30 Cook Medical Technologies Llc Anti-aspiration valve
US20130289699A1 (en) 2012-04-30 2013-10-31 St. Jude Medical, Cardiology Division, Inc. Aortic valve holder with stent protection and/or ability to decrease valve profile
CA2871153A1 (en) 2012-05-09 2013-11-14 Boston Scientific Scimed, Inc. Reduced profile valve with locking elements
CN104334120B (zh) 2012-05-15 2016-10-26 瓣膜医学有限公司 用于组装折叠的经皮瓣膜的系统和方法
CA2871156C (en) 2012-05-16 2020-06-30 Edwards Lifesciences Corporation Devices and methods for reducing cardiac valve regurgitation
US9878127B2 (en) 2012-05-16 2018-01-30 Jenavalve Technology, Inc. Catheter delivery system for heart valve prosthesis
CA2872611C (en) 2012-05-16 2020-09-15 Edwards Lifesciences Corporation Systems and methods for placing a coapting member between valvular leaflets
CN104684505B (zh) 2012-05-20 2017-07-07 戴尔马修墨医学研究内结构和服务有限公司 人造二尖瓣
WO2013173997A1 (zh) 2012-05-24 2013-11-28 上海欣吉特生物科技有限公司 人工心脏瓣膜
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9642700B2 (en) 2012-05-31 2017-05-09 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve having a polymeric stent
DE102012010798A1 (de) 2012-06-01 2013-12-05 Universität Duisburg-Essen Implantierbare Vorrichtung zur Verbesserung oder Behebung einer Herzklappeninsuffizienz
US9301835B2 (en) 2012-06-04 2016-04-05 Edwards Lifesciences Corporation Pre-assembled bioprosthetic valve and sealed conduit
WO2013182614A1 (en) 2012-06-05 2013-12-12 Kardiozis Endoprosthesis and delivery device for implanting such endoprosthesis
KR102313261B1 (ko) 2012-06-05 2021-10-14 메리트 메디컬 시스템즈, 인크. 식도 스텐트
FR2991162B1 (fr) 2012-06-05 2015-07-17 Ass Marie Lannelongue Endoprothese, notamment vasculaire ou cardiaque, avec elements thrombogenes
CN104470579B (zh) 2012-06-06 2018-06-01 洋红医疗有限公司 人工肾脏瓣膜
CA2874453C (en) 2012-06-06 2021-05-18 Loma Vista Medical, Inc. Inflatable medical devices
US20130331931A1 (en) 2012-06-07 2013-12-12 Boston Scientific Scimed Inc. Apparatus for Replacing a Native Heart Valve and Method of Making the Same
WO2013185073A1 (en) 2012-06-08 2013-12-12 Cameron International Corporation Artificial heart system
US9526610B2 (en) 2012-06-12 2016-12-27 Medtronic, Inc. Method and device for percutaneous valve annuloplasty
US9883941B2 (en) 2012-06-19 2018-02-06 Boston Scientific Scimed, Inc. Replacement heart valve
US10413402B2 (en) 2012-06-22 2019-09-17 Pierre Squara Heart valve prostheses
US9289292B2 (en) 2012-06-28 2016-03-22 St. Jude Medical, Cardiology Division, Inc. Valve cuff support
US9918837B2 (en) 2012-06-29 2018-03-20 St. Jude Medical, Cardiology Division, Inc. System to assist in the release of a collapsible stent from a delivery device
US20140005776A1 (en) 2012-06-29 2014-01-02 St. Jude Medical, Cardiology Division, Inc. Leaflet attachment for function in various shapes and sizes
US9615920B2 (en) 2012-06-29 2017-04-11 St. Jude Medical, Cardiology Divisions, Inc. Commissure attachment feature for prosthetic heart valve
US9241791B2 (en) 2012-06-29 2016-01-26 St. Jude Medical, Cardiology Division, Inc. Valve assembly for crimp profile
ES2690824T3 (es) 2012-07-02 2018-11-22 Boston Scientific Scimed, Inc. Formación de prótesis valvular cardiaca
US9498202B2 (en) 2012-07-10 2016-11-22 Edwards Lifesciences Corporation Suture securement devices
WO2014011888A1 (en) 2012-07-12 2014-01-16 Boston Scientific Scimed, Inc. Low profile heart valve delivery system and method
JP6463265B2 (ja) 2012-07-20 2019-01-30 クック・メディカル・テクノロジーズ・リミテッド・ライアビリティ・カンパニーＣｏｏｋ Ｍｅｄｉｃａｌ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｌｃ スリーブを有する植え込み型医療デバイス
US9283072B2 (en) 2012-07-25 2016-03-15 W. L. Gore & Associates, Inc. Everting transcatheter valve and methods
US9271856B2 (en) 2012-07-25 2016-03-01 Medtronic Vascular Galway Delivery catheter with distal moving capsule for transapical prosthetic heart valve delivery
US9364358B2 (en) 2012-07-27 2016-06-14 Medinol Ltd. Catheter with retractable cover and pressurized fluid
US10376360B2 (en) 2012-07-27 2019-08-13 W. L. Gore & Associates, Inc. Multi-frame prosthetic valve apparatus and methods
US9254141B2 (en) 2012-08-02 2016-02-09 St. Jude Medical, Inc. Apparatus and method for heart valve repair
EP2695586B1 (en) 2012-08-10 2019-05-08 Sorin Group Italia S.r.l. A valve prosthesis and kit
US9468525B2 (en) 2012-08-13 2016-10-18 Medtronic, Inc. Heart valve prosthesis
CN102805676B (zh) 2012-08-14 2015-06-17 杭州启明医疗器械有限公司 人造瓣膜置换装置的压缩装置
DE102012107465A1 (de) 2012-08-15 2014-05-22 Pfm Medical Ag Implantierbare Einrichtung zur Verwendung im menschlichen und/oder tierischen Körper zum Ersatz einer Organklappe
US10022224B2 (en) 2012-08-17 2018-07-17 On-X Life Technologies, Inc. Biological chord repair system and methods
US9649212B2 (en) 2012-08-30 2017-05-16 Biotronik Ag Release device for releasing a medical implant from a catheter and catheter comprising a release device
US9717595B2 (en) 2012-09-05 2017-08-01 Medtronic Vascular Galway Trans-aortic delivery system with containment capsule centering device
DE102012216742A1 (de) 2012-09-19 2014-03-20 Hans-Hinrich Sievers Herzklappenprothese
WO2014044789A1 (en) 2012-09-21 2014-03-27 Materialise N.V. Patient-specific intraluminal implants
CN103655004B (zh) 2012-09-21 2015-11-25 上海微创医疗器械（集团）有限公司 植入体输送系统
WO2014046065A1 (ja) 2012-09-21 2014-03-27 国立大学法人大阪大学 心筋・血管再生デバイスとしての重症心不全治療材
US9585748B2 (en) 2012-09-25 2017-03-07 Edwards Lifesciences Corporation Methods for replacing a native heart valve and aorta with a prosthetic heart valve and conduit
CA2885354A1 (en) 2012-09-29 2014-04-03 Mitralign, Inc. Plication lock delivery system and method of use thereof
EP2712633B1 (de) 2012-10-02 2015-04-29 Biotronik AG Bioprosthetische Komponenten für ein Implantat, insbesondere teilvernetzte biologische Herzklappen
WO2014056644A1 (en) 2012-10-09 2014-04-17 Biotronik Ag Crimping tool for a prosthetic device and method for crimping a prosthetic device with a crimping tool
FR2996747B1 (fr) 2012-10-11 2015-02-06 Cormove Implant destine a etre insere dans un conduit de circulation du sang
US9801721B2 (en) 2012-10-12 2017-10-31 St. Jude Medical, Cardiology Division, Inc. Sizing device and method of positioning a prosthetic heart valve
FR2996748B1 (fr) 2012-10-12 2015-02-06 Cormove Dispositif de traitement d'un conduit de circulation du sang
US9295549B2 (en) 2012-10-12 2016-03-29 St. Jude Medical, Cardiology Division, Inc. Valve holder and loading integration
EP3510974B1 (en) 2012-10-18 2023-11-29 Loma Vista Medical, Inc. Reinforced inflatable medical devices
WO2014062448A1 (en) 2012-10-19 2014-04-24 Boston Scientific Scimed, Inc. Anti-thrombus feature for implanted medical devices
WO2014064694A2 (en) 2012-10-23 2014-05-01 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
US10376266B2 (en) 2012-10-23 2019-08-13 Valtech Cardio, Ltd. Percutaneous tissue anchor techniques
WO2014066081A1 (en) 2012-10-24 2014-05-01 Cook Medical Technologies Llc Anti-reflux prosthesis
FR2997288B1 (fr) 2012-10-25 2015-01-23 Cormove Dispositif de mise en place d'une etancheite autour d'un implant dans un passage de circulation du sang, et necessaire de traitement associe
US9192751B2 (en) 2012-10-26 2015-11-24 Medtronic, Inc. Elastic introducer sheath
DE102012219752A1 (de) 2012-10-29 2014-04-30 Aesculap Ag Stabilisator für Operationen am schlagenden Herzen
US9636441B2 (en) 2012-11-05 2017-05-02 Robert Jarvik Support stent for transvalvular conduit
US20140128964A1 (en) 2012-11-08 2014-05-08 Symetis Sa Stent Seals and Methods for Sealing an Expandable Stent
US20140135907A1 (en) 2012-11-09 2014-05-15 Medtronic CV Luxembourg S.a.r.l. Medical Device Delivery System and Methods of Delivering Medical Devices
US9144493B2 (en) 2012-11-14 2015-09-29 Medtronic Vascular Galway Limited Valve prosthesis deployment assembly and method
FR2998166B1 (fr) 2012-11-16 2016-02-26 Engin Oder Prothese annulaire pour la therapie de la valve mitrale par annulo-plastie
ES2610992T3 (es) 2012-11-20 2017-05-04 Innovheart S.R.L. Dispositivo para desplegar un sistema de alambres guías dentro de una cámara cardíaca para implantar una válvula cardíaca protésica
DK3158975T3 (da) 2012-11-20 2023-03-13 Innovheart S R L Protesesystem til hjerteklaperstatning
US11400261B2 (en) 2012-11-21 2022-08-02 Concert Medical, Llc Preformed guidewire
EP4162902A1 (en) 2012-11-21 2023-04-12 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic heart valves
US20140142689A1 (en) 2012-11-21 2014-05-22 Didier De Canniere Device and method of treating heart valve malfunction
US9199348B2 (en) 2012-11-27 2015-12-01 Medtronic, Inc. Prosthetic valve crimping
EP2928538B1 (en) 2012-12-07 2018-11-21 Valcare, Inc. Devices for percutaneously anchoring annuloplasty rings
EP2742911A1 (de) 2012-12-17 2014-06-18 Hans Reiner Figulla Klappenprothese zum Ersatz einer Atrioventricularklappe
US10039638B2 (en) 2012-12-19 2018-08-07 W. L. Gore & Associates, Inc. Geometric prosthetic heart valves
US9737398B2 (en) 2012-12-19 2017-08-22 W. L. Gore & Associates, Inc. Prosthetic valves, frames and leaflets and methods thereof
US9968443B2 (en) 2012-12-19 2018-05-15 W. L. Gore & Associates, Inc. Vertical coaptation zone in a planar portion of prosthetic heart valve leaflet
US9398952B2 (en) 2012-12-19 2016-07-26 W. L. Gore & Associates, Inc. Planar zone in prosthetic heart valve leaflet
US9101469B2 (en) 2012-12-19 2015-08-11 W. L. Gore & Associates, Inc. Prosthetic heart valve with leaflet shelving
US9144492B2 (en) 2012-12-19 2015-09-29 W. L. Gore & Associates, Inc. Truncated leaflet for prosthetic heart valves, preformed valve
US10321986B2 (en) 2012-12-19 2019-06-18 W. L. Gore & Associates, Inc. Multi-frame prosthetic heart valve
US10966820B2 (en) 2012-12-19 2021-04-06 W. L. Gore & Associates, Inc. Geometric control of bending character in prosthetic heart valve leaflets
US9008769B2 (en) 2012-12-21 2015-04-14 Backbeat Medical, Inc. Methods and systems for lowering blood pressure through reduction of ventricle filling
WO2014102268A1 (en) 2012-12-27 2014-07-03 Transcatheter Technologies Gmbh Apparatus and set for folding or unfolding a medical implant comprising a clamping mechanism, implant and method
DE102013200152A1 (de) 2013-01-08 2014-07-10 AdjuCor GmbH Herzunterstützungsvorrichtung mit einer selbst-expandierenden Schale
EP2752170B1 (en) 2013-01-08 2017-02-22 Cook Medical Technologies LLC Multi valve anti-reflux prosthesis
US9066801B2 (en) 2013-01-08 2015-06-30 Medtronic, Inc. Valve prosthesis and method for delivery
EP2943132B1 (en) 2013-01-09 2018-03-28 4Tech Inc. Soft tissue anchors
US9955990B2 (en) 2013-01-10 2018-05-01 Intervene, Inc. Systems and methods for endoluminal valve creation
FR3001121B1 (fr) 2013-01-18 2016-01-15 Ladjali Mustapha Dr Pince de traitement d'un tissu corporel et necessaire de traitement associe
US20150351906A1 (en) 2013-01-24 2015-12-10 Mitraltech Ltd. Ventricularly-anchored prosthetic valves
KR20150140634A (ko) 2013-01-25 2015-12-16 메드텐티아 인터내셔날 엘티디 오와이 판륜성형술 임플란트의 선택을 용이하게 위한 의료 디바이스 및 방법
CN104994812B (zh) 2013-01-25 2017-05-17 梅德坦提亚国际有限公司 用于接管和/或临时或部分支撑心脏中的天然瓣膜的短时间置换的瓣膜及其递送方法
CA2897907A1 (en) 2013-01-25 2014-07-31 Medtentia International Ltd Oy Temporary atrium support device
US10856983B2 (en) 2013-01-25 2020-12-08 Medtentia International Ltd. Oy System for cardiac valve repair
JP6600558B2 (ja) 2013-01-25 2019-10-30 メドテンシア インターナショナル エルティーディー オーワイ 腱索及び／又は弁尖の収集のための装置、医療システム、及び方法
US10413401B2 (en) 2013-02-01 2019-09-17 Medtronic CV Luxembourg S.a.r.l. Anti-paravalvular leakage component for a transcatheter valve prosthesis
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
JP6280932B2 (ja) 2013-02-04 2018-02-14 トゥエルヴ， インコーポレイテッド 人工心臓弁デバイスのための液圧送達システムおよび関連方法
EP3231395B1 (en) 2013-02-06 2022-08-24 Boston Scientific Limited Prosthetic valve and delivery apparatus
EP2958520B1 (en) 2013-02-21 2018-12-19 St. Jude Medical, Cardiology Division, Inc. Transapical delivery system
EP2769681B1 (en) 2013-02-22 2019-08-21 Biotronik AG Release device for detaching a medical implant from an insertion device and an insertion device comprising a release device
EP2769742A1 (en) 2013-02-22 2014-08-27 Cardiatis S.A. MRI visible medical device.
CN104000672B (zh) 2013-02-25 2016-06-15 上海微创心通医疗科技有限公司 心脏瓣膜假体
EP2961358B1 (en) 2013-02-28 2019-06-26 Boston Scientific Scimed, Inc. Implantable medical devices for reduced tissue inflammation
US9155616B2 (en) 2013-02-28 2015-10-13 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve with expandable microspheres
WO2014133539A1 (en) 2013-03-01 2014-09-04 Cormatrix Cardiovascular, Inc. Anchored cardiovascular valve
ITPI20130015A1 (it) 2013-03-07 2014-09-08 S M Scienzia Machinale S R L Apparecchiatura e metodo per la produzione di un oggetto tridimensionale biocompatibile
EP2964152B1 (en) 2013-03-07 2021-04-28 Medtronic Vascular Galway Prosthesis for transcatheter valve implantation
CA2904715C (en) 2013-03-08 2022-07-26 Carnegie Mellon University Expandable implantable fluoropolymer conduit
EP2964277B1 (en) 2013-03-08 2018-10-24 St. Jude Medical, Cardiology Division, Inc. Method of preparing a tissue swatch for a bioprosthetic device
US9808364B2 (en) 2013-03-11 2017-11-07 Cook Medical Technologies Llc Systems and methods for maintaining perfusion of branch vessels
US10583002B2 (en) 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
US9744032B2 (en) 2013-03-11 2017-08-29 Cook Medical Technologies Llc Endoluminal prosthesis comprising a valve and an axially extendable segment
US9119713B2 (en) 2013-03-11 2015-09-01 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve replacement
WO2014164302A1 (en) 2013-03-12 2014-10-09 Edwards Lifesciences Corporation Systems and methods for ensuring safe and rapid deployment of prosthetic heart valves
US8986375B2 (en) 2013-03-12 2015-03-24 Medtronic, Inc. Anti-paravalvular leakage component for a transcatheter valve prosthesis
EP2967853B1 (en) 2013-03-12 2019-11-06 Medtronic Inc. Heart valve prosthesis
CN105073068B (zh) 2013-03-12 2017-03-15 爱德华兹生命科学公司 可快速部署的外科心脏瓣膜
CN105007955B (zh) 2013-03-13 2018-06-22 W.L.戈尔及同仁股份有限公司 适用于植入物的耐用高强度聚合物复合材料及其制品
CN105517509B (zh) 2013-03-13 2017-08-08 爱德华兹生命科学卡迪尔克有限责任公司 铰接式连合瓣膜支架和方法
JP2014176302A (ja) 2013-03-13 2014-09-25 Seiko Epson Corp 核酸増幅反応装置及び核酸増幅方法
US9326856B2 (en) 2013-03-14 2016-05-03 St. Jude Medical, Cardiology Division, Inc. Cuff configurations for prosthetic heart valve
CN105228558B (zh) 2013-03-14 2017-06-20 捷迈有限公司 假膝植入体
US20140277427A1 (en) 2013-03-14 2014-09-18 Cardiaq Valve Technologies, Inc. Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9687346B2 (en) 2013-03-14 2017-06-27 Edwards Lifesciences Corporation Multi-stranded heat set annuloplasty rings
EP2967810B1 (en) 2013-03-14 2020-04-22 Suzhou Jiecheng Medical Technology Co., Ltd. Embolic protection devices
EP2777616B1 (en) 2013-03-14 2020-08-19 Edwards Lifesciences CardiAQ LLC Prosthesis for atraumatically grasping intralumenal tissue
WO2014160330A1 (en) 2013-03-14 2014-10-02 Millepede, Llc. Systems and methods for reshaping a heart valve
ES2824628T3 (es) 2013-03-14 2021-05-12 Valve Medical Ltd Válvula temporal
JP6329570B2 (ja) 2013-03-14 2018-05-23 ４テック インコーポレイテッド テザーインターフェースを有するステント
JP6397887B2 (ja) 2013-03-15 2018-09-26 トゥエルヴ， インコーポレイテッド 人工心臓弁デバイス、人工僧帽弁、ならびに関連システム及び方法
US9232998B2 (en) 2013-03-15 2016-01-12 Cardiosolutions Inc. Trans-apical implant systems, implants and methods
CN107714240B (zh) 2013-03-15 2021-04-02 西美蒂斯股份公司 涉及经导管支架-瓣膜的改进
US9232994B2 (en) 2013-03-15 2016-01-12 Medtronic Vascular Galway Limited Stented prosthetic heart valve and methods for making
US20140276979A1 (en) 2013-03-15 2014-09-18 Lsi Solutions, Inc. Method and devices for securing bidirectional suture loops using coaxial mechanical fasteners
EP2777617B1 (en) 2013-03-15 2022-09-14 Edwards Lifesciences CardiAQ LLC Prosthesis with outer skirt
US9289297B2 (en) 2013-03-15 2016-03-22 Cardiosolutions, Inc. Mitral valve spacer and system and method for implanting the same
EP3804646B1 (en) 2013-03-15 2024-11-13 Valcare Medical, Inc. Systems for delivery of annuloplasty rings
US9486314B2 (en) 2013-03-15 2016-11-08 Hlt, Inc. Low-profile prosthetic valve structure
CN103190968B (zh) 2013-03-18 2015-06-17 杭州启明医疗器械有限公司 一种支架以及具有该支架的安装稳固的人造瓣膜置换装置
FR2998167B1 (fr) 2013-03-20 2015-01-09 Marco Vola Dispositif pour realiser une annuloplastie par voie transapicale de la valve mitrale
DE102013205519B4 (de) 2013-03-27 2019-05-23 Fehling Instruments Gmbh & Co. Kg Spreizer für den Vorhof des Herzens
EP2789312A1 (en) 2013-04-09 2014-10-15 Epygon Sasu Expandable stent-valve and method for manufacturing a stent
EP2986256B1 (en) 2013-04-19 2019-04-10 Strait Access Technologies Holdings (Pty) Ltd A prosthetic heart valve
FR3004638B1 (fr) 2013-04-19 2015-05-29 Invalv Lab Implant, notamment destine a etre place dans une valve auriculo-ventriculaire cardiaque, comportant un systeme d'ecartement des bras proximaux
FR3004917B1 (fr) 2013-04-25 2016-06-10 Bernard Pain Appareil de mesure du diametre d'une valve aortique
EP2991587A4 (en) 2013-05-01 2016-05-18 Aneumed Inc PERSONALIZED AORTIC FLUTE PROSTHESIS
DE102013208038B4 (de) 2013-05-02 2016-09-08 Michael Siegenthaler Katheterbasierendes Herzunterstützungssystem
US9375311B2 (en) 2013-05-03 2016-06-28 Medtronic, Inc. Prosthetic valves and associated appartuses, systems and methods
WO2014178971A1 (en) 2013-05-03 2014-11-06 Cormatrix Cardiovascular, Inc. Prosthetic tissue valves and methods for anchoring same to cardiovascular structures
KR101429005B1 (ko) 2013-05-06 2014-08-12 부산대학교 산학협력단 심장판막 고정장치
US9937330B2 (en) 2013-05-07 2018-04-10 Cook Medical Technologies Llc System, method, and kit for providing the diameter of a balloon during treatment
CN105377192A (zh) 2013-05-09 2016-03-02 米塔埃瑟斯医疗有限公司 心脏瓣膜辅助修复体
AU2014262488B2 (en) 2013-05-10 2018-08-30 Medtronic, Inc. System for deploying a device to a distal location across a diseased vessel
EP2803335B1 (en) 2013-05-14 2017-09-27 Venus MedTech (HangZhou), Inc. Apparatus for folding or unfolding a medical implant, and implant
EP3326583B1 (en) 2013-05-20 2018-12-12 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
CN105246431B (zh) 2013-05-20 2018-04-06 托尔福公司 可植入心脏瓣膜装置、二尖瓣修复装置以及相关系统和方法
EP2805695A1 (en) 2013-05-21 2014-11-26 Medtentia International Ltd Oy Medical system for annuloplasty
ES2800029T3 (es) 2013-05-21 2020-12-23 V Wave Ltd Aparato para aplicar dispositivos para reducir la presión atrial izquierda
US20160089235A1 (en) 2013-05-22 2016-03-31 Valcare, Inc. Transcatheter prosthetic valve for mitral or tricuspid valve replacement
EP2805678B1 (en) 2013-05-22 2017-05-17 Medtentia International Ltd Oy Stitching device
EP3003452B1 (en) 2013-05-24 2019-09-11 Bioventrix, Inc. Cardiac tissue penetrating devices
CN104173121B (zh) 2013-05-27 2016-05-25 上海微创心通医疗科技有限公司 用于输送植入体的电动手柄及输送系统
US20140358224A1 (en) 2013-05-30 2014-12-04 Tendyne Holdlings, Inc. Six cell inner stent device for prosthetic mitral valves
FR3006582B1 (fr) 2013-06-05 2015-07-17 Mustapha Ladjali Dispositif de traitement d'un tissu corporel et necessaire de traitement associe
CN106618802B (zh) 2013-06-06 2018-02-06 戴维·阿隆 心脏瓣膜修复和更换
WO2014201452A1 (en) 2013-06-14 2014-12-18 Cardiosolutions, Inc. Mitral valve spacer and system and method for implanting the same
US20160151145A1 (en) 2013-06-16 2016-06-02 Pi-Cardia Ltd. Percutaneous emboli protection sleeve
DE102013106352A1 (de) 2013-06-18 2014-12-18 Universität Zu Lübeck Herzunterstützungssystem sowie Herzunterstützungsverfahren
FR3006884B1 (fr) 2013-06-18 2016-06-24 Laboratoires Invalv Dispositif atraumatique d'introduction d'un element tubulaire creux dans un organe biologique
WO2014204840A1 (en) 2013-06-18 2014-12-24 St. Jude Medical, Cardiology Division, Inc. Transapical introducer
WO2014204807A1 (en) 2013-06-19 2014-12-24 Aga Medical Corporation Collapsible valve having paravalvular leak protection
US9320841B2 (en) 2013-06-21 2016-04-26 Corvivo, Inc. Ventricular assist device
CN108814772B (zh) 2013-06-25 2020-09-08 坦迪尼控股股份有限公司 用于假体心脏瓣膜的血栓管理和结构顺应特征
US9895228B2 (en) * 2013-06-28 2018-02-20 Edwards Lifesciences Corporation Covered heart valve sizer
US10028832B2 (en) 2013-07-10 2018-07-24 Medtronic, Inc. Helical coil mitral valve annuloplasty systems and methods
DE102013107369A1 (de) 2013-07-11 2015-01-15 Rational Aktiengesellschaft Verfahren zum Erstellen sowie zur Verwendung eines Anwenderprofils eines Gargerätes und ein Gargerät
US9237948B2 (en) 2013-07-11 2016-01-19 Medtronic, Inc. Delivery system with projections
CN105073026B (zh) 2013-07-11 2018-02-02 爱德华兹生命科学公司 无结缝合线固定器安装系统
EP2826443B1 (en) 2013-07-16 2017-06-28 Venus MedTech (HangZhou), Inc. Set comprising an apparatus and a medical implant
US8870948B1 (en) 2013-07-17 2014-10-28 Cephea Valve Technologies, Inc. System and method for cardiac valve repair and replacement
CN105517616B (zh) 2013-07-22 2019-04-09 梅约医学教育与研究基金会 用于使引导导管自对中的装置
FR3008885B1 (fr) 2013-07-26 2016-12-30 Landanger Dispositif chirurgical notamment pour la pose de prothese de cordage mitrale
EP2832316B1 (en) 2013-07-31 2017-03-29 Venus MedTech (HangZhou), Inc. Handle assembly for implant delivery apparatus comprising a displacement limiter, a force limiter and/or a brake frame assembly
EP2832317B1 (en) 2013-07-31 2017-02-15 Venus MedTech (HangZhou), Inc. Implant delivery device for folding or unfolding a medical implant based on a knot
EP2832315B1 (en) 2013-07-31 2017-11-22 Venus MedTech (HangZhou), Inc. Handle assembly for implant delivery apparatus comprising a brake frame assembly, a force limiter and/or a displacement limiter
EP2918246B1 (en) 2014-03-14 2018-08-08 Venus MedTech (HangZhou), Inc. Heart valve assembly comprising twofold sealing
WO2015017714A2 (en) 2013-07-31 2015-02-05 Cvdevices, Llc Unitary body systems and devices and methods to use the same for retroperfusion
EP2918245B1 (en) 2014-03-14 2017-05-03 Venus MedTech (HangZhou), Inc. Heart valve comprising a crown piece interconnected to leaflets, a top cuff and a bottom cuff; and a medical implant
EP2832318B1 (en) 2013-07-31 2017-04-05 Venus MedTech (HangZhou), Inc. Handle assembly for implant delivery apparatus comprising a force limiter, a displacement limiter and/or a brake frame assembly
CN105555231B (zh) 2013-08-01 2018-02-09 坦迪尼控股股份有限公司 心外膜锚固装置和方法
EP2835112B1 (en) 2013-08-08 2021-01-27 Sorin Group Italia S.r.l. Heart valve prosthesis
US20150051696A1 (en) 2013-08-14 2015-02-19 Boston Scientific Scimed, Inc. Medical guidewire
CA2920865C (en) * 2013-08-14 2023-06-06 Mitral Valve Technologies Sarl Replacement heart valve apparatus and methods
ES2660196T3 (es) 2013-08-14 2018-03-21 Sorin Group Italia S.R.L. Aparato para el reemplazo de cuerdas
WO2015031124A1 (en) 2013-08-29 2015-03-05 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve with lyophilized tissue
DK2842581T3 (en) 2013-08-30 2019-02-18 Georg August Univ Goettingen Stiftung Oeffentlichen Rechts Univsmedizin Bag-like structure with paracrine activity and process for its preparation
EP3038539B1 (en) 2013-08-30 2021-08-18 Bioventrix, Inc. Heart anchor positioning devices for treatment of congestive heart failure and other conditions
WO2015028209A1 (en) 2013-08-30 2015-03-05 Jenavalve Technology Gmbh Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
WO2015038615A1 (en) 2013-09-12 2015-03-19 St. Jude Medical, Cardiology Division, Inc. Atraumatic interface in an implant delivery device
WO2015038458A1 (en) 2013-09-12 2015-03-19 St. Jude Medical, Cardiology Division, Inc. Stent designs for prosthetic heart valves
US10123870B2 (en) 2013-09-12 2018-11-13 St. Jude Medical, Cardiology Division, Inc. Alignment of an implantable medical device
GB201316349D0 (en) 2013-09-13 2013-10-30 Ucl Business Plc Vascular implant
EP4473947A3 (en) 2013-09-16 2025-02-19 Boston Scientific Medical Device Ltd. A loading tube apparatus for compressing/loading stent-valves
EP2853237A1 (en) 2013-09-25 2015-04-01 Universität Zürich Biological heart valve replacement, particularly for pediatric patients, and manufacturing method
JP6505674B2 (ja) 2013-09-27 2019-04-24 テヘニース ウニフェルシテイト アイントホーフェン 培養中に予め画定されたインサートを用いることによる組織工学心臓弁の形状の制御
US9615922B2 (en) 2013-09-30 2017-04-11 Edwards Lifesciences Corporation Method and apparatus for preparing a contoured biological tissue
US20150094803A1 (en) 2013-09-30 2015-04-02 The Cleveland Clinic Foundation Apparatus and method for treating a regurgitant heart valve
EP3052053B1 (en) 2013-10-05 2020-08-12 Sino Medical Sciences Technology, Inc. Device for mitral valve regurgitation method
WO2015058001A1 (en) 2013-10-17 2015-04-23 Cedars-Sinai Medical Center Device to percutaneously treat heart valve embolization
US9788944B2 (en) 2013-10-21 2017-10-17 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve implantation access sheaths
EP3060174B1 (en) 2013-10-22 2020-05-27 Concievalve LLC Methods for inhibiting stenosis, obstruction, or calcification of a stented heart valve or bioprosthesis
US10182910B2 (en) 2013-10-23 2019-01-22 Biotronik Ag Method for fitting an implant to a catheter
US10646333B2 (en) 2013-10-24 2020-05-12 Medtronic, Inc. Two-piece valve prosthesis with anchor stent and valve component
US9662202B2 (en) 2013-10-24 2017-05-30 Medtronic, Inc. Heart valve prosthesis
US9414913B2 (en) 2013-10-25 2016-08-16 Medtronic, Inc. Stented prosthetic heart valve
US10531953B2 (en) 2013-10-28 2020-01-14 Symetis Sa Stent-valve, delivery apparatus and method of use
CN104586542B (zh) 2013-10-31 2017-01-04 上海微创心通医疗科技有限公司 一种将植入体装载到输送系统中的装置和方法
EP2870946B1 (en) 2013-11-06 2018-10-31 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak sealing mechanism
EP2870945B1 (en) 2013-11-08 2016-07-06 Nvt Ag Deployment system for vascular implants
CA2934975A1 (en) 2013-11-11 2015-05-14 Edwards Lifesciences Cardiaq Llc Systems and methods for manufacturing a stent frame
US9839765B2 (en) 2013-11-12 2017-12-12 St. Jude Medical, Cardiology Division, Inc. Transfemoral mitral valve repair delivery device
WO2015073815A1 (en) 2013-11-15 2015-05-21 Guy's And St. Thomas' Nhs Foundation Trust Information markers for heart prostheses and methods of using same
US9889004B2 (en) 2013-11-19 2018-02-13 St. Jude Medical, Cardiology Division, Inc. Sealing structures for paravalvular leak protection
US9848880B2 (en) 2013-11-20 2017-12-26 James E. Coleman Adjustable heart valve implant
US9603600B2 (en) 2013-11-20 2017-03-28 James E. Coleman Actuator for deployable implant
US9622863B2 (en) 2013-11-22 2017-04-18 Edwards Lifesciences Corporation Aortic insufficiency repair device and method
US10098734B2 (en) 2013-12-05 2018-10-16 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
US9504565B2 (en) 2013-12-06 2016-11-29 W. L. Gore & Associates, Inc. Asymmetric opening and closing prosthetic valve leaflet
CN111991117B (zh) 2013-12-11 2023-10-24 雪松-西奈医学中心 用于在双孔二尖瓣中经导管二尖瓣置换的装置
KR102471841B1 (ko) 2013-12-19 2022-11-29 백비트 메디컬 엘엘씨 심방 압력을 조절하여 혈압을 조절하는 방법 및 시스템
US9610162B2 (en) 2013-12-26 2017-04-04 Valtech Cardio, Ltd. Implantation of flexible implant
CN103750922B (zh) 2013-12-31 2016-07-13 金仕生物科技（常熟）有限公司 制备人工心脏瓣膜瓣叶的方法
CN103735337B (zh) 2013-12-31 2016-08-17 金仕生物科技（常熟）有限公司 人工心脏瓣膜成形环
US9943408B2 (en) 2014-01-08 2018-04-17 St. Jude Medical, Cardiology Division, Inc. Basket delivery system
US9539090B2 (en) 2014-01-16 2017-01-10 Cook Medical Technologies Llc Transaortic valve access device
EP2896387A1 (en) 2014-01-20 2015-07-22 Mitricares Heart valve anchoring device
US10327890B2 (en) 2014-01-22 2019-06-25 Biotronik Ag Thermochemically treated miniature tubes as semifinished products for vascular stents
EP3096713B1 (en) 2014-01-23 2022-09-21 President and Fellows of Harvard College Engineered polymeric valves, tubular structures and sheets
US9820852B2 (en) 2014-01-24 2017-11-21 St. Jude Medical, Cardiology Division, Inc. Stationary intra-annular halo designs for paravalvular leak (PVL) reduction—active channel filling cuff designs
US9750603B2 (en) 2014-01-27 2017-09-05 Medtronic Vascular Galway Stented prosthetic heart valve with variable stiffness and methods of use
AU2015211083B2 (en) 2014-01-28 2019-11-07 Sanford Health Pararenal and thoracic arch stent graft and methods for use
CN105744969B (zh) 2014-01-31 2019-12-31 雪松-西奈医学中心 用于最优主动脉瓣膜复合体成像和对准的猪尾装置
KR102432831B1 (ko) 2014-02-04 2022-08-12 이노브하르트 에세.에레.엘레. 심장 판막용 인공 디바이스
EP3102150B1 (en) 2014-02-07 2023-08-09 C. R. Bard, Inc. Polymer composite-covered stents
EP2904989A1 (en) 2014-02-11 2015-08-12 Kephalios S.A.S. Adjustable annuloplasty device
US9913717B2 (en) 2014-02-14 2018-03-13 Edwards Lifesciences Corporation Percutaneous leaflet augmentation
HRP20211867T1 (hr) 2014-02-18 2022-03-04 Edwards Lifesciences Corporation Fleksibilni okvir spojišta
EP2907479A1 (en) 2014-02-18 2015-08-19 Medtentia International Ltd Oy A system and a method for delivery of an annuloplasty implant
EP3107495B2 (en) 2014-02-18 2025-05-14 St. Jude Medical, Cardiology Division, Inc. Bowed runners and corresponding valve assemblies for paravalvular leak protection
US11672652B2 (en) 2014-02-18 2023-06-13 St. Jude Medical, Cardiology Division, Inc. Bowed runners for paravalvular leak protection
CA2938614C (en) * 2014-02-21 2024-01-23 Edwards Lifesciences Cardiaq Llc Delivery device for controlled deployement of a replacement valve
CA3189691A1 (en) 2014-02-21 2015-08-27 Mitral Valve Technologies Sarl Devices, systems and methods for delivering a prosthetic mitral valve and anchoring device
US10426880B2 (en) 2014-02-25 2019-10-01 MI-VAD, Inc. Ventricular assist device and method
CA2940415C (en) 2014-02-28 2022-11-01 Highlife Sas Transcatheter valve prosthesis
CN106456325B (zh) 2014-02-28 2020-03-03 高品质生活简化股份公司 经导管瓣膜假体
EP2918248A1 (en) 2014-03-11 2015-09-16 Epygon Sasu An expandable stent-valve and a delivery device
EP2918247A1 (en) 2014-03-11 2015-09-16 Epygon Sasu A prosthetic valve and a delivery device
EP2918249B1 (de) 2014-03-14 2020-04-29 Venus MedTech (HangZhou), Inc. Supraclaviculäres kathetersystem für einen transseptalen zugang zum linken vorhof und linken ventrikel
US9668861B2 (en) 2014-03-15 2017-06-06 Rex Medical, L.P. Vascular device for treating venous valve insufficiency
GB2527075A (en) 2014-03-17 2015-12-16 Daassist As Percutaneous system, devices and methods
US10390943B2 (en) 2014-03-17 2019-08-27 Evalve, Inc. Double orifice device for transcatheter mitral valve replacement
ES2618355T3 (es) 2014-03-18 2017-06-21 Nvt Ag Sistema de manipulación de la válvula cardíaca protésica
EP2921139B1 (en) 2014-03-18 2018-11-21 Nvt Ag Heartvalve implant
EP3119351B1 (en) 2014-03-18 2021-10-20 St. Jude Medical, Cardiology Division, Inc. Mitral valve replacement toggle cell securement
JP6411043B2 (ja) 2014-03-20 2018-10-24 学校法人東邦大学 弁尖形成用テンプレート
EP2923665B1 (de) 2014-03-26 2018-10-17 Biotronik AG Kathetervorrichtung zur minimalinvasiven Implantation eines Gefäßimplantats, insbesondere für die interventionelle, kathetergestützte Aortenklappenimplantation
WO2015152980A1 (en) 2014-03-31 2015-10-08 St. Jude Medical, Cardiology Division, Inc. Paravalvular sealing via extended cuff mechanisms
WO2015153755A2 (en) 2014-04-01 2015-10-08 Medtronic Inc. Anti-paravalvular leakage component for a transcatheter valve prosthesis
EP2926840B1 (de) 2014-04-02 2018-05-09 Biotronik AG Verfahren zur Aufbereitung von biologischem Gewebe zur trockenen Verwendung in einem Implantat
PL2929860T3 (pl) 2014-04-07 2018-01-31 Nvt Ag Urządzenie do wszczepiania w serce ssaka
US11116496B2 (en) 2014-04-08 2021-09-14 Lsi Solutions, Inc. Surgical suturing device for a replacement anatomical structure and methods thereof
WO2015158789A1 (en) 2014-04-16 2015-10-22 Alma Mater Studiorum - Università di Bologna Heart valve prosthesis with integrated electronic circuit for measuring intravalvular electrical impedance, and system for monitoring functionality of the prosthesis
EP3131503B1 (en) 2014-04-17 2019-06-12 Medtronic Vascular Galway Hinged transcatheter prosthetic heart valve delivery system
US10321987B2 (en) 2014-04-23 2019-06-18 Medtronic, Inc. Paravalvular leak resistant prosthetic heart valve system
FR3020265B1 (fr) 2014-04-24 2019-09-06 Cormove Dispositif de mise en place d'une etancheite autour d'un implant dans un passage de circulation du sang, et necessaire de traitement associe
US10154904B2 (en) 2014-04-28 2018-12-18 Edwards Lifesciences Corporation Intravascular introducer devices
JP6566445B2 (ja) 2014-05-06 2019-08-28 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． 人工弁の製造方法およびそれにより得られる弁
WO2015169866A1 (en) 2014-05-06 2015-11-12 Dsm Ip Assets B.V. Prosthetic valve and method of making a prosthetic valve
WO2015169870A1 (en) 2014-05-06 2015-11-12 Dsm Ip Assets B.V. Method of making a prosthetic valve and valve obtained therewith
US10195025B2 (en) 2014-05-12 2019-02-05 Edwards Lifesciences Corporation Prosthetic heart valve
USRE49792E1 (en) 2014-05-14 2024-01-09 Corcym S.R.L. Implant device and implantation kit
WO2015175524A1 (en) 2014-05-16 2015-11-19 St. Jude Medical, Cardiology Division, Inc. Subannular sealing for paravalvular leak protection
EP3145445B1 (en) 2014-05-21 2019-03-20 SWAT Medical AB Improved embolic protection device
JP6755858B2 (ja) 2014-05-21 2020-09-16 マレティ, オスカーMALETI, Oscar 下肢に逆流を生じる疾患を治療するための人工弁
EP3145449B2 (en) 2014-05-21 2023-12-13 St. Jude Medical, Cardiology Division, Inc. Self-expanding heart valves for coronary perfusion and sealing
EP3145450B1 (en) 2014-05-22 2019-07-17 St. Jude Medical, Cardiology Division, Inc. Stents with anchoring sections
US9757232B2 (en) 2014-05-22 2017-09-12 Edwards Lifesciences Corporation Crimping apparatus for crimping prosthetic valve with protruding anchors
FR3021208B1 (fr) 2014-05-23 2021-03-12 Thomas Modine Prothese de valve cardiaque mitrale ou tricuspide
EP3134033B1 (en) 2014-05-29 2018-04-04 Edwards Lifesciences CardiAQ LLC Prosthesis and delivery device
FR3021863A1 (fr) 2014-06-05 2015-12-11 Bernard Pain Dispositif d'introduction transcatheter dans la racine aortique au niveau de la jonction sino tubulaire
FR3021860A1 (fr) 2014-06-05 2015-12-11 Bernard Pain Dispositif transcatheter pour l'ablation de tissus calcifies au niveau des volets d'une valve aortique
FR3021862B1 (fr) 2014-06-10 2016-05-20 Vygon Kit d'operation pour mise en place de valve aortique
EP2954875B1 (en) 2014-06-10 2017-11-15 St. Jude Medical, Cardiology Division, Inc. Stent cell bridge for cuff attachment
ES2693507T3 (es) 2014-06-17 2018-12-12 Consiglio Nazionale Delle Ricerche Un procedimiento de fabricación de una válvula cardíaca hecha de un material de polímero y válvula cardíaca obtenida de este modo
EP3157469B2 (en) 2014-06-18 2024-10-02 Polares Medical Inc. Mitral valve implants for the treatment of valvular regurgitation
WO2015193728A2 (en) 2014-06-19 2015-12-23 4Tech Inc. Cardiac tissue cinching
ES2914153T3 (es) 2014-06-24 2022-06-07 Polares Medical Inc Sistemas para anclar un implante
US9700412B2 (en) 2014-06-26 2017-07-11 Mitralix Ltd. Heart valve repair devices for placement in ventricle and delivery systems for implanting heart valve repair devices
WO2016001382A2 (en) 2014-07-02 2016-01-07 Medtentia International Ltd Oy Clip for a medical implant
CN106470642B (zh) 2014-07-03 2019-01-22 梅德坦提亚国际有限公司 一种瓣膜成形术系统
CN104055604B (zh) 2014-07-07 2016-06-01 宁波健世生物科技有限公司 一种带锚定装置的心脏瓣膜植入器械
FR3023704B1 (fr) 2014-07-15 2016-08-26 Mustapha Ladjali Dispositif de traitement endovasculaire d'une valve cardiaque en vue d'un remplacement valvulaire percutane
EP3169276B1 (de) 2014-07-16 2020-10-14 Medira Ag Herzklappenprothese zum perkutanen ersatz einer trikuspidalklappe und system mit einer derartigen herzklappenprothese
EP3154474B1 (de) 2014-07-16 2021-11-10 P+F Products + Features GmbH Herzklappenprothese zum perkutanen ersatz einer trikuspidalklappe, set und system mit einer derartigen herzklappenprothese
CN106999174B (zh) 2014-07-17 2019-08-23 核心医疗股份公司 用于心瓣修复的医疗设备及方法
US9180005B1 (en) 2014-07-17 2015-11-10 Millipede, Inc. Adjustable endolumenal mitral valve ring
EP2979685B1 (en) 2014-07-29 2017-07-12 Coty Germany Gmbh Film forming complex, cosmetic composition comprising it and their use as peel-off film mask
EP2979667B2 (de) 2014-07-30 2020-10-28 Biotronik AG Einführvorrichtung für ein medizinisches implantat in einen menschlichen und/oder tierischen körper
EP3174502B1 (en) 2014-07-30 2022-04-06 Cardiovalve Ltd Apparatus for implantation of an articulatable prosthetic valve
EP2979664B1 (en) 2014-08-01 2019-01-09 Alvimedica Tibbi Ürünler Sanayi Ve Dis Ticaret A.S Aortic valve prosthesis, particularly suitable for transcatheter implantation
US9801719B2 (en) 2014-08-15 2017-10-31 Edwards Lifesciences Corporation Annulus rings with suture clips
EP3182930B1 (en) 2014-08-18 2020-09-23 St. Jude Medical, Cardiology Division, Inc. Sensors for prosthetic heart devices
EP3182932B1 (en) 2014-08-18 2019-05-15 St. Jude Medical, Cardiology Division, Inc. Annuloplasty ring with sensor
US10058424B2 (en) * 2014-08-21 2018-08-28 Edwards Lifesciences Corporation Dual-flange prosthetic valve frame
JP2017527373A (ja) 2014-09-08 2017-09-21 メドテンティア・インターナショナル・リミテッド・オサケユキチュアＭｅｄｔｅｎｔｉａ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｔｄ Ｏｙ 弁輪形成インプラント
JP5738461B1 (ja) 2014-09-08 2015-06-24 重之 尾崎 弁尖サイザー
EP3922218A1 (en) 2014-09-09 2021-12-15 Occlutech Holding AG A flow regulating device in the heart
US9827094B2 (en) 2014-09-15 2017-11-28 W. L. Gore & Associates, Inc. Prosthetic heart valve with retention elements
GB2536538B (en) 2014-09-17 2018-07-18 Cardiomech As Anchor for implantation in body tissue
EP3000436B1 (de) 2014-09-24 2017-04-05 Alexander Lauten System zum Ersatz einer an einer Entzündung oder einer Infektion erkrankten Klappe des Herzens
WO2016046599A1 (en) 2014-09-24 2016-03-31 Sorin Group Italia S.R.L. A holder for heart valve prostheses, corresponding storage arrangement, delivery instrument and kit
ES2676060T3 (es) 2014-09-26 2018-07-16 Nvt Ag Dispositivo implantable para el tratamiento de la regurgitación de la válvula mitral
RU2017114607A (ru) 2014-09-28 2018-10-29 Кардиокинетикс, Инк. Устройства для терапии нарушений функции сердца
US10390950B2 (en) 2014-10-03 2019-08-27 St. Jude Medical, Cardiology Division, Inc. Flexible catheters and methods of forming same
DE102014114762B3 (de) 2014-10-10 2016-03-03 Asanus Medizintechnik Gmbh Aortenklappenklemme und Instrumentensatz zur Aortenklappenrekonstruktion
EP3206631B1 (en) 2014-10-13 2022-07-06 Boston Scientific Limited Catheter delivery system for stent valve
EP3009104B1 (en) 2014-10-14 2019-11-20 St. Jude Medical, Cardiology Division, Inc. Flexible catheter and methods of forming same
EP3206629B1 (en) 2014-10-14 2021-07-14 Valtech Cardio, Ltd. Apparatus for heart valve leaflet restraining
FR3027212A1 (fr) 2014-10-16 2016-04-22 Seguin Jacques Implant intervalvulaire pour valve mitrale
US10105225B2 (en) 2014-10-22 2018-10-23 Medtronic, Inc. Devices, systems and methods for tissue approximation, including approximating mitral valve leaflets
WO2016066180A1 (en) 2014-10-30 2016-05-06 Osypka Stiftung Peter Transmyocardial insertion unit and its use
US10213307B2 (en) 2014-11-05 2019-02-26 Medtronic Vascular, Inc. Transcatheter valve prosthesis having an external skirt for sealing and preventing paravalvular leakage
WO2016079737A2 (en) 2014-11-17 2016-05-26 Mitrassist Medical Ltd. Heart valve prosthesis
DE102014223522A1 (de) 2014-11-18 2016-05-19 Hans-Hinrich Sievers Biologische Herzklappenprothese
US10709821B2 (en) 2014-11-24 2020-07-14 Biotronik Ag Sealing structure for heart valve implants
CN106999178B (zh) 2014-12-02 2019-12-24 4科技有限公司 偏心组织锚定器
CR20170245A (es) 2014-12-05 2017-09-14 Edwards Lifesciences Corp Cateter dirigible con cable de tracción
EP3718510A1 (en) 2014-12-18 2020-10-07 W. L. Gore & Associates, Inc. Prosthetic valves with mechanically coupled leaflets
EP3037064B1 (en) 2014-12-23 2018-03-14 Venus MedTech (HangZhou), Inc. Minimally invasive mitral valve replacement with brim
JPWO2016098877A1 (ja) 2014-12-19 2017-11-02 国立研究開発法人国立循環器病研究センター 人工弁形成基材及び人工弁
EP3237033B1 (en) 2014-12-22 2020-08-05 Syntach AG An implantable hydraulic displacement actuator and system.
US10092428B2 (en) 2014-12-30 2018-10-09 Cook Medical Technologies Llc Low profile prosthesis delivery device
EP3242629B1 (en) 2015-01-05 2018-12-12 David Alon Heart ventricle remodeling
US9579195B2 (en) 2015-01-13 2017-02-28 Horizon Scientific Corp. Mitral bileaflet valve
EP3247312B1 (en) 2015-01-21 2021-06-16 Medtronic Inc. Prosthetic valve sizer and assembly including same
EP3253332B2 (en) 2015-02-02 2024-09-04 Boston Scientific Medical Device Limited Stent seals and method of production
EP3220971B1 (en) 2015-02-03 2019-09-04 Boston Scientific Scimed Inc. Methods and devices for treating pericardial tissue
CA2975294A1 (en) 2015-02-05 2016-08-11 Tendyne Holdings, Inc. Expandable epicardial pads and devices and methods for delivery of same
US10231834B2 (en) 2015-02-09 2019-03-19 Edwards Lifesciences Corporation Low profile transseptal catheter and implant system for minimally invasive valve procedure
US10039637B2 (en) 2015-02-11 2018-08-07 Edwards Lifesciences Corporation Heart valve docking devices and implanting methods
US20160235525A1 (en) 2015-02-12 2016-08-18 Medtronic, Inc. Integrated valve assembly and method of delivering and deploying an integrated valve assembly
AU2015382370A1 (en) 2015-02-13 2017-08-17 W.L. Gore & Associates, Inc. Coherent single layer high strength synthetic polymer composites for prosthetic valves
US10413400B2 (en) 2015-02-24 2019-09-17 Rijksuniversiteit Groningen Mechanical heart valve prosthesis for the right ventricle
FR3033494B1 (fr) 2015-03-10 2017-03-24 Carmat Endoprothese tissulaire et procede pour sa realisation
US10758349B2 (en) 2015-03-13 2020-09-01 Medtronic Vascular, Inc. Delivery device for prosthetic heart valve with capsule adjustment device
WO2016150806A1 (en) 2015-03-20 2016-09-29 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath
US9962260B2 (en) 2015-03-24 2018-05-08 St. Jude Medical, Cardiology Division, Inc. Prosthetic mitral valve
CN107157622B (zh) 2015-03-26 2019-12-17 杭州启明医疗器械股份有限公司 使用安全的瓣膜支架以及具有该瓣膜支架的瓣膜置换装置
DE102015206099A1 (de) 2015-04-02 2016-10-06 Hans-Hinrich Sievers Herzklappenprothese
DE102015206098B4 (de) 2015-04-02 2018-09-27 Hans-Hinrich Sievers Implantationshilfe für eine biologische Herzklappenprothese sowie Herzklappenprothesensystem
DE102015206097A1 (de) 2015-04-02 2016-10-06 Hans-Hinrich Sievers Herzklappenprothese
FR3034642B1 (fr) 2015-04-07 2021-01-15 Benjamin Faurie Introducteur pour ensemble de remplacement d'une valve cardiaque ou pour ensemble d'angioplastie coronaire
US10314696B2 (en) 2015-04-09 2019-06-11 Boston Scientific Scimed, Inc. Prosthetic heart valves having fiber reinforced leaflets
EP3078350B1 (en) 2015-04-09 2018-01-31 Frid Mind Technologies 3d filter for prevention of stroke
US10792471B2 (en) 2015-04-10 2020-10-06 Edwards Lifesciences Corporation Expandable sheath
US10327896B2 (en) 2015-04-10 2019-06-25 Edwards Lifesciences Corporation Expandable sheath with elastomeric cross sectional portions
US10368986B2 (en) 2015-04-15 2019-08-06 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system and method
EP3695810B1 (en) 2015-04-16 2022-05-18 Tendyne Holdings, Inc. Apparatus for retrieval of transcatheter prosthetic valves
US9931790B2 (en) 2015-04-16 2018-04-03 Siemens Healthcare Gmbh Method and system for advanced transcatheter aortic valve implantation planning
US10064718B2 (en) 2015-04-16 2018-09-04 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
US10441416B2 (en) 2015-04-21 2019-10-15 Edwards Lifesciences Corporation Percutaneous mitral valve replacement device
KR101588310B1 (ko) 2015-04-22 2016-01-25 (주)태웅메디칼 심낭막을 이용한 인공심장판막 및 그 제조방법
US9782256B2 (en) 2015-04-27 2017-10-10 Venus Medtech (Hangzhou) Inc Heart valve assembly
CN106175985B (zh) 2015-04-29 2018-08-24 上海微创心通医疗科技有限公司 用于输送植入体的驱动手柄及输送系统
US10232564B2 (en) 2015-04-29 2019-03-19 Edwards Lifesciences Corporation Laminated sealing member for prosthetic heart valve
EP3087952A1 (en) 2015-04-29 2016-11-02 Kephalios S.A.S. An annuloplasty system and a method for monitoring the effectiveness of an annuloplasty treatment
US10376363B2 (en) 2015-04-30 2019-08-13 Edwards Lifesciences Cardiaq Llc Replacement mitral valve, delivery system for replacement mitral valve and methods of use
CA2984325C (en) 2015-04-30 2024-01-02 Silk Road Medical, Inc. Systems and methods for transcatheter aortic valve treatment
CN107530168B (zh) 2015-05-01 2020-06-09 耶拿阀门科技股份有限公司 在心脏瓣膜替换中具有降低的起搏器比例的装置和方法
US11141220B2 (en) 2015-05-01 2021-10-12 Feops Nv Method and system for determining a risk of cardiac conduction abnormalities
US9629720B2 (en) 2015-05-04 2017-04-25 Jacques Seguin Apparatus and methods for treating cardiac valve regurgitation
GB2538072B (en) 2015-05-05 2017-11-15 Strait Access Tech Holdings (Pty) Ltd A non-occlusive dilation and deployment catheter device
JP6595210B2 (ja) 2015-05-08 2019-10-23 株式会社日本医療機器開発機構 大動脈弁再建術トレーニングキット
DE102015107242B4 (de) 2015-05-08 2022-11-03 Highlife Sas System zum Implantieren eines Implantats um eine umfängliche Gewebestruktur in einem Herz und Verfahren zum Anordnen und Vorbringen eines Implantats auf einem Führungsdraht eines solchen Systems
US10980973B2 (en) 2015-05-12 2021-04-20 Ancora Heart, Inc. Device and method for releasing catheters from cardiac structures
ES3001450T3 (en) 2015-05-14 2025-03-05 Edwards Lifesciences Corp Heart valve sealing devices and delivery devices therefor
GB2538749B (en) 2015-05-27 2017-08-02 Univ Dublin City Inflatable balloon
EP3302362B1 (en) 2015-05-28 2020-11-11 St. Jude Medical, Cardiology Division, Inc. System for loading a collapsible heart valve having a leaflet restraining member
WO2016189391A2 (en) 2015-05-28 2016-12-01 4Tech Inc. Off-center tissue anchors with tension members
EP3539509B1 (en) 2015-06-01 2021-07-07 Edwards Lifesciences Corporation Cardiac valve repair devices configured for percutaneous delivery
JP6760971B2 (ja) 2015-06-04 2020-09-23 エピゴン 天然弁葉を把持および保持する機構を含む房室弁ステント
CA2988949C (en) 2015-06-08 2023-10-03 Northwestern University Annuloplasty ring for receiving a replacement valve
US10314707B2 (en) 2015-06-09 2019-06-11 Edwards Lifesciences, Llc Asymmetric mitral annuloplasty band
GB2539444A (en) 2015-06-16 2016-12-21 Ucl Business Plc Prosthetic heart valve
EP3316821B1 (en) 2015-06-30 2021-01-20 Robert V. Snyders Lifetime regenerative heart valve
CR20170577A (es) 2015-07-02 2019-05-03 Edwards Lifesciences Corp Válvulas cardíacas híbridas adaptadas para expansión post implante
US10716671B2 (en) 2015-07-02 2020-07-21 Boston Scientific Scimed, Inc. Prosthetic heart valve composed of composite fibers
CN107920894B (zh) 2015-07-02 2020-04-28 爱德华兹生命科学公司 整合的混合心脏瓣膜
CN108348332A (zh) 2015-07-03 2018-07-31 赛姆斯股份公司 用于人工瓣膜的球囊导管
DE102015212699A1 (de) 2015-07-07 2017-01-12 AdjuCor GmbH Implantierbare Vorrichtung zur ortsgenauen Zuführung und Applikation von Substanzen in das Perikard oder auf die Herzoberfläche
US9974650B2 (en) 2015-07-14 2018-05-22 Edwards Lifesciences Corporation Prosthetic heart valve
WO2017011199A1 (en) 2015-07-16 2017-01-19 St. Jude Medical, Cardiology Division, Inc. Sutureless prosthetic heart valve
ITUB20152409A1 (it) 2015-07-22 2017-01-22 Sorin Group Italia Srl Manicotto valvolare per protesi valvolari e corrispondente dispositivo
EP3328318B1 (en) 2015-07-28 2019-08-21 Boston Scientific Scimed, Inc. Valve delivery system with pinless release mechanism
JP6735814B2 (ja) 2015-08-11 2020-08-05 テルモ株式会社 インプラント配送のためのシステムおよび方法
US10368983B2 (en) 2015-08-12 2019-08-06 St. Jude Medical, Cardiology Division, Inc. Collapsible heart valve including stents with tapered struts
US10709553B2 (en) 2015-08-12 2020-07-14 Boston Scientific Scimed, Inc. V-Clip post with pivoting
US10925726B2 (en) 2015-08-12 2021-02-23 Boston Scientific Scimed, Inc. Everting leaflet delivery system with pivoting
US10179041B2 (en) 2015-08-12 2019-01-15 Boston Scientific Scimed Icn. Pinless release mechanism
AU2016308017B2 (en) 2015-08-14 2020-10-29 Caisson Interventional Llc Systems and methods for heart valve therapy
US10179046B2 (en) 2015-08-14 2019-01-15 Edwards Lifesciences Corporation Gripping and pushing device for medical instrument
US9895222B2 (en) 2015-08-17 2018-02-20 Venus Medtech (Hangzhou) Inc. Aortic replacement valve
US11357499B2 (en) 2015-08-18 2022-06-14 Lsi Solutions, Inc. Apparatus for mitral valve repair and methods thereof
EP3365349B1 (en) 2015-08-18 2022-06-15 University of Pittsburgh- Of the Commonwealth System of Higher Education Viologen-functionalized porphyrins for reducing biofouling on surfaces
US11026788B2 (en) 2015-08-20 2021-06-08 Edwards Lifesciences Corporation Loader and retriever for transcatheter heart valve, and methods of crimping transcatheter heart valve
US10631977B2 (en) 2015-08-24 2020-04-28 Edwards Lifesciences Corporation Covering and assembly method for transcatheter valve
CN108348315B (zh) 2015-08-25 2020-03-10 尹诺文有限责任公司 静脉瓣膜假体
US10575951B2 (en) 2015-08-26 2020-03-03 Edwards Lifesciences Cardiaq Llc Delivery device and methods of use for transapical delivery of replacement mitral valve
CN112043463B (zh) 2015-08-26 2024-03-08 爱德华兹生命科学公司 受控气囊部署
US10350066B2 (en) 2015-08-28 2019-07-16 Edwards Lifesciences Cardiaq Llc Steerable delivery system for replacement mitral valve and methods of use
CA2995855C (en) 2015-09-02 2024-01-30 Edwards Lifesciences Corporation Spacer for securing a transcatheter valve to a bioprosthetic cardiac structure
US10850064B2 (en) 2015-09-03 2020-12-01 St. Jude Medical, Cardiology Division, Inc. Introducer sheath having expandable portions
WO2017040926A1 (en) 2015-09-04 2017-03-09 The Trustees Of The University Of Pennsylvania Systems and methods for percutaneous removal of objects from an internal body space
US10080653B2 (en) 2015-09-10 2018-09-25 Edwards Lifesciences Corporation Limited expansion heart valve
EP3347182B1 (en) 2015-09-11 2022-07-13 S.M. Scienzia Machinale S.r.l Apparatus and method for producing a biocompatible three-dimensional object
US10195023B2 (en) 2015-09-15 2019-02-05 Boston Scientific Scimed, Inc. Prosthetic heart valves including pre-stressed fibers
US10478288B2 (en) 2015-09-30 2019-11-19 Clover Life Sciences Inc. Trileaflet mechanical prosthetic heart valve
ES2554296B1 (es) 2015-10-02 2017-01-18 Jose Ignacio ARAMENDI GALLARDO Anillo subaórtico reabsorbible
US10195024B2 (en) 2015-10-07 2019-02-05 Boston Scientific Scimed, Inc. Porcine small intestine submucosa leaflet material
US9872765B2 (en) 2015-10-12 2018-01-23 Venus Medtech (Hangzhou) Inc Mitral valve assembly
AU2016339984A1 (en) 2015-10-14 2018-04-26 Heart Repair Technologies, Inc. Transvalvular intraannular band for mitral valve repair
US10350067B2 (en) 2015-10-26 2019-07-16 Edwards Lifesciences Corporation Implant delivery capsule
CN108471974B (zh) 2015-10-28 2022-02-18 皇家飞利浦有限公司 主动脉瓣状态的发信号示意
US10266657B2 (en) 2015-10-29 2019-04-23 Commonwealth Scientific And Industrial Research Organisation Polyurethane/urea compositions
US20170143478A1 (en) 2015-11-02 2017-05-25 Robert S. Schwartz Devices and methods for reducing cardiac valve regurgitation
US9592121B1 (en) 2015-11-06 2017-03-14 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
US10321996B2 (en) 2015-11-11 2019-06-18 Edwards Lifesciences Corporation Prosthetic valve delivery apparatus having clutch mechanism
WO2017087424A1 (en) 2015-11-17 2017-05-26 Millipede, Inc. Implantable device and delivery system for reshaping a heart valve annulus
US10143554B2 (en) 2015-12-03 2018-12-04 Medtronic Vascular, Inc. Venous valve prostheses
DE102015121501A1 (de) 2015-12-10 2017-06-14 Biotronik Ag Einführkatheter und Katheteranordnung
US11008676B2 (en) 2015-12-16 2021-05-18 Edwards Lifesciences Corporation Textured woven fabric for use in implantable bioprostheses
PL3184081T3 (pl) 2015-12-22 2021-10-04 Medira Ag Urządzenie protetyczne do wspomagania koaptacji zastawki mitralnej
EP3184082B1 (en) 2015-12-23 2022-08-17 P+F Products + Features Vertriebs GmbH Stent for a surgical valve
CA3006010C (en) 2015-12-28 2023-09-26 Tendyne Holdings, Inc. Atrial pocket closures for prosthetic heart valves
US10426619B2 (en) 2015-12-30 2019-10-01 Avvie Gmbh Implant and method for improving coaptation of an atrioventricular valve
EP3818963B1 (en) 2015-12-30 2025-08-27 Caisson Interventional, LLC Systems for heart valve therapy
JP2019501729A (ja) 2016-01-14 2019-01-24 カーディアティス・エス・ア 大動脈弁不全を含む胸部大動脈疾患用の植込み型プロテーゼ
CN108882978B (zh) 2016-01-22 2020-11-06 梅德坦提亚国际有限公司 瓣膜成形术植入物
JP6658773B2 (ja) 2016-01-25 2020-03-04 株式会社リコー 立体造形物、立体造形物の製造方法、立体造形物の製造装置、立体造形用材料セット、及びハイドロゲル前駆体液
US20170209268A1 (en) 2016-01-27 2017-07-27 Medtronic, Inc. Systems and methods for repositioning a fully deployed valve assembly
US10342660B2 (en) 2016-02-02 2019-07-09 Boston Scientific Inc. Tensioned sheathing aids
EP3410984B1 (en) 2016-02-04 2023-03-29 Boston Scientific Scimed, Inc. Mitral valve inversion prostheses
US10363130B2 (en) 2016-02-05 2019-07-30 Edwards Lifesciences Corporation Devices and systems for docking a heart valve
AU2017218708B2 (en) 2016-02-08 2022-02-03 Innoventric Ltd. Treatment of tricuspid insufficiency
US10376681B2 (en) 2016-02-29 2019-08-13 Edwards Lifesciences Corporation Vacuum-based compliance restoration
DE102016103843A1 (de) 2016-03-03 2017-09-07 Biotronik Ag Reduktion von paravalvulärer Leckage durch kontrollierten Thrombusaufbau
EP3213714A1 (de) 2016-03-03 2017-09-06 Biotronik AG Einführkatheter und katheteranordnung
US10779941B2 (en) 2016-03-08 2020-09-22 Edwards Lifesciences Corporation Delivery cylinder for prosthetic implant
US10398549B2 (en) 2016-03-15 2019-09-03 Abbott Cardiovascular Systems Inc. System and method for transcatheter heart valve platform
EP3578138A1 (en) 2016-03-22 2019-12-11 Assistance Publique, Hopitaux De Paris Vascular valved prosthesis and manufacturing method
US10512757B2 (en) 2016-03-25 2019-12-24 Project Moray, Inc. Fluid-actuated sheath displacement and articulation behavior improving systems, devices, and methods for catheters, continuum manipulators, and other uses
GB2548891B (en) 2016-03-31 2018-07-04 I Birdi Ltd A prosthetic device for mitral valve repair
DE102016106575A1 (de) 2016-04-11 2017-10-12 Biotronik Ag Herzklappenprothese
US10159569B2 (en) 2016-04-12 2018-12-25 Lars Erickson Minimally invasive atrio-ventricular valve treatment by chordae adjustment
CN105852916B (zh) 2016-04-14 2018-02-06 上海甲悦医疗器械有限公司 一种经心尖植入的二尖瓣柔性闭合板阻塞体及植入方法
US10485658B2 (en) 2016-04-22 2019-11-26 Backbeat Medical, Inc. Methods and systems for controlling blood pressure
US10624743B2 (en) 2016-04-22 2020-04-21 Edwards Lifesciences Corporation Beating-heart mitral valve chordae replacement
US10405974B2 (en) 2016-04-26 2019-09-10 Boston Scientific Scimed, Inc. Replacement heart valve with improved stitching
US10792149B2 (en) 2016-04-27 2020-10-06 Strait Access Technologies Holdings (Pty) Ltd Expandable stent and methods of crimping and expanding such stent
US10406011B2 (en) 2016-04-28 2019-09-10 Medtronic Vascular, Inc. Implantable medical device delivery system
US10231829B2 (en) 2016-05-04 2019-03-19 Boston Scientific Scimed Inc. Leaflet stitching backer
US10172710B2 (en) 2016-05-10 2019-01-08 William Joseph Drasler Two component mitral valve
WO2017197065A1 (en) 2016-05-13 2017-11-16 St. Jude Medical, Cardiology Division, Inc. Systems for device implantation
CN109475419B (zh) 2016-05-13 2021-11-09 耶拿阀门科技股份有限公司 用于通过引导鞘和装载系统来递送心脏瓣膜假体的心脏瓣膜假体递送系统和方法
US20170325952A1 (en) 2016-05-13 2017-11-16 Boston Scientific Scimed, Inc. Implant release system
US10583005B2 (en) 2016-05-13 2020-03-10 Boston Scientific Scimed, Inc. Medical device handle
US10321994B2 (en) 2016-05-13 2019-06-18 St. Jude Medical, Cardiology Division, Inc. Heart valve with stent having varying cell densities
US11116630B2 (en) 2016-05-16 2021-09-14 Boston Scientific Scimed, Inc. Sheathing aid
ES2986575T3 (es) 2016-05-16 2024-11-12 Valve Medical Ltd Vaina de válvula temporal inversora
US10201416B2 (en) 2016-05-16 2019-02-12 Boston Scientific Scimed, Inc. Replacement heart valve implant with invertible leaflets
CN109561955B (zh) 2016-05-16 2021-04-16 万能医药公司 撑开支架
EP3457990B1 (en) 2016-05-17 2022-11-30 Boston Scientific Scimed, Inc. Replacement heart valve implant with inflow stitching
US10368982B2 (en) 2016-05-19 2019-08-06 Boston Scientific Scimed, Inc. Prosthetic valves, valve leaflets and related methods
CN109152641B (zh) 2016-06-02 2020-08-21 美敦力瓦斯科尔勒公司 具有隔膜孔闭合末端组件的经导管瓣膜递送系统
US20200337726A1 (en) 2016-06-03 2020-10-29 Intervene, Inc. Devices for manipulating blood vessel walls and associated systems and methods of use
WO2017216607A1 (en) 2016-06-15 2017-12-21 Sorin Group Italia S.R.L Two-part mitral valve and implant method
DE102016111323A1 (de) 2016-06-21 2017-12-21 Biotronik Ag Einführkatheter und Katheteranordnung
US10639147B2 (en) 2016-06-24 2020-05-05 Edwards Lifesciences Corporation System and method for crimping a prosthetic valve
US11090157B2 (en) 2016-06-30 2021-08-17 Tendyne Holdings, Inc. Prosthetic heart valves and apparatus and methods for delivery of same
CN107550524B (zh) 2016-07-01 2020-01-03 先健科技(深圳)有限公司 输送装置
KR20190037233A (ko) 2016-07-06 2019-04-05 더 메서디스트 하스피틀 애뉼러-심실 커플링 메커니즘을 포함하는 인공 승모판막
US10736632B2 (en) 2016-07-06 2020-08-11 Evalve, Inc. Methods and devices for valve clip excision
US10973638B2 (en) 2016-07-07 2021-04-13 Edwards Lifesciences Corporation Device and method for treating vascular insufficiency
GB201611910D0 (en) 2016-07-08 2016-08-24 Valtech Cardio Ltd Adjustable annuloplasty device with alternating peaks and troughs
US10828150B2 (en) 2016-07-08 2020-11-10 Edwards Lifesciences Corporation Docking station for heart valve prosthesis
EP3484413B1 (en) 2016-07-12 2020-05-13 Medtronic Inc. Prosthetic valve for regulating fluid flow
GB201612180D0 (en) 2016-07-13 2016-08-24 Ucl Business Plc Bioprosthetic heart valve
US10478304B2 (en) 2016-07-20 2019-11-19 Abbott Cardiovascular Systems Inc. Independent system for tricuspid valve repair
US10058426B2 (en) 2016-07-20 2018-08-28 Abbott Cardiovascular Systems Inc. System for tricuspid valve repair
US10350062B2 (en) 2016-07-21 2019-07-16 Edwards Lifesciences Corporation Replacement heart valve prosthesis
CN106175986B (zh) 2016-07-26 2017-12-01 复旦大学附属中山医院 一种瓣膜夹合器
US10758382B2 (en) 2016-07-27 2020-09-01 Sainath Intellectual Property, LLC Stent with one-way sock valve
US10646689B2 (en) 2016-07-29 2020-05-12 Cephea Valve Technologies, Inc. Mechanical interlock for catheters
US10974027B2 (en) 2016-07-29 2021-04-13 Cephea Valve Technologies, Inc. Combination steerable catheter and systems
US11324495B2 (en) 2016-07-29 2022-05-10 Cephea Valve Technologies, Inc. Systems and methods for delivering an intravascular device to the mitral annulus
US11096781B2 (en) 2016-08-01 2021-08-24 Edwards Lifesciences Corporation Prosthetic heart valve
ES3018641T3 (es) 2016-08-10 2025-05-16 Cardiovalve Ltd Válvula protésica con marcos concéntricos
US10828152B2 (en) 2016-08-11 2020-11-10 4C Medical Technologies, Inc. Heart chamber prosthetic valve implant with base, spring and dome sections with single chamber anchoring for preservation, supplementation and/or replacement of native valve function
JP6632047B2 (ja) 2016-08-18 2020-01-15 ４テック インコーポレイテッド 囲心腔への挿入のための可撓性先端部を有する組織アンカー
CR20190069A (es) 2016-08-26 2019-05-14 Edwards Lifesciences Corp Valvulas y sistemas de acoplamiento de valvulas corazon
CN114569289A (zh) 2016-08-26 2022-06-03 爱德华兹生命科学公司 多部分置换心脏瓣膜假体
WO2018039543A1 (en) 2016-08-26 2018-03-01 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve with paravalvular leak mitigation features
US10751485B2 (en) 2016-08-29 2020-08-25 Cephea Valve Technologies, Inc. Methods, systems, and devices for sealing and flushing a delivery system
US10575946B2 (en) 2016-09-01 2020-03-03 Medtronic Vascular, Inc. Heart valve prosthesis and separate support flange for attachment thereto
WO2018052927A1 (en) 2016-09-15 2018-03-22 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve with paravalvular leak mitigation features
EP3512465B1 (en) 2016-09-15 2021-09-01 Cardiac Implants LLC An apparatus for delivering a cardiac annulus ring
US10052201B2 (en) 2016-09-21 2018-08-21 Peijia Medical Co., Ltd. Valved stent for mitral and tricuspid heart valve replacement
US10575944B2 (en) 2016-09-22 2020-03-03 Edwards Lifesciences Corporation Prosthetic heart valve with reduced stitching
US10874512B2 (en) 2016-10-05 2020-12-29 Cephea Valve Technologies, Inc. System and methods for delivering and deploying an artificial heart valve within the mitral annulus
FR3057154B1 (fr) 2016-10-07 2018-10-19 Electroducer Electrode transcutanee pour ensemble de remplacement d'une valve cardiaque ou ensemble d'angioplastie coronaire comprenant un catheter de delivrance ou un introducteur
ES2892273T3 (es) 2016-10-07 2022-02-03 Electroducer Conjunto de sustitución de una válvula cardíaca o de un conjunto de angioplastia coronaria
EP3311774B1 (en) 2016-10-19 2022-05-11 P+F Products + Features Vertriebs GmbH Self-expandable atrioventricular valve and system of cardiac valves
CN107374782B (zh) 2016-10-20 2023-04-18 上海微创心通医疗科技有限公司 植入体输送装置
DE202016105963U1 (de) 2016-10-24 2018-01-25 Nvt Ag Intraluminale Gefäßprothese zur Implantation in das Herz oder Herzgefäße eines Patienten
CN110072491B (zh) 2016-10-31 2020-06-26 心脏植入物有限公司 用于在安装到心脏瓣膜环上之前揭示收缩绳索或环圈的位置的不透射线的柔性突起
US10722356B2 (en) 2016-11-03 2020-07-28 Edwards Lifesciences Corporation Prosthetic mitral valve holders
US11376121B2 (en) 2016-11-04 2022-07-05 Highlife Sas Transcatheter valve prosthesis
US9999502B2 (en) 2016-11-04 2018-06-19 Highlife Sas Transcather valve prosthesis
US10653862B2 (en) 2016-11-07 2020-05-19 Edwards Lifesciences Corporation Apparatus for the introduction and manipulation of multiple telescoping catheters
US10869991B2 (en) 2016-11-09 2020-12-22 Medtronic Vascular, Inc. Telescoping catheter
US10363138B2 (en) 2016-11-09 2019-07-30 Evalve, Inc. Devices for adjusting the curvature of cardiac valve structures
DE102016013480A1 (de) 2016-11-11 2018-05-17 Peter Osypka Stiftung Vorrichtung zur Ballondilatation einer verengten Herzklappe
US10398553B2 (en) 2016-11-11 2019-09-03 Evalve, Inc. Opposing disk device for grasping cardiac valve tissue
FR3058631B1 (fr) 2016-11-14 2019-01-25 Laboratoires Invalv Implant de traitement d'une valve biologique
FR3058632B1 (fr) 2016-11-14 2019-01-25 Laboratoires Invalv Dispositif de traitement d'une valve biologique avec organe de poussee de la valve
US20180133006A1 (en) 2016-11-15 2018-05-17 Medtronic Vascular, Inc. Stabilization and advancement system for direct aortic transcatheter aortic valve implantation
US10959841B2 (en) 2016-11-15 2021-03-30 Hancock Jaffe Laboratories, Inc. Implantable vein frame
US10426616B2 (en) 2016-11-17 2019-10-01 Evalve, Inc. Cardiac implant delivery system
CN110177594B (zh) 2016-11-22 2022-07-29 波士顿科学国际有限公司 抗压缩和/或拉伸的医疗装置轴
US11013588B2 (en) 2016-11-23 2021-05-25 St. Jude Medical, Cardiology Division, Inc. Tissue heart valve (THV) humidor packaging system
US10548614B2 (en) 2016-11-29 2020-02-04 Evalve, Inc. Tricuspid valve repair system
US10702381B2 (en) 2016-12-01 2020-07-07 Boston Scientific Scimed, Inc. Heart valve remodeling device
FR3060292B1 (fr) 2016-12-15 2019-01-25 Cmi'nov Dispositif pour realiser ou preparer une annuloplastie mitrale par voie transfemorale
JP7440263B2 (ja) 2016-12-16 2024-02-28 エドワーズ ライフサイエンシーズ コーポレイション 人工弁用のアンカリングデバイスを送達するための展開システム、ツール、および方法
SG10202109534TA (en) 2016-12-20 2021-10-28 Edwards Lifesciences Corp Systems and mechanisms for deploying a docking device for a replacement heart valve
EP3342355B1 (en) 2016-12-29 2020-04-22 Medtentia International Ltd Oy Medical securing device for securing an object with a securing member
EP3568089B1 (en) 2017-01-11 2021-09-15 Virender K. Sharma Cardiac shunt device and delivery system
US10463517B2 (en) 2017-01-16 2019-11-05 Cook Medical Technologies Llc Controlled expansion stent graft delivery system
CA3051272C (en) 2017-01-23 2023-08-22 Cephea Valve Technologies, Inc. Replacement mitral valves
US11185406B2 (en) 2017-01-23 2021-11-30 Edwards Lifesciences Corporation Covered prosthetic heart valve
ES2886225T3 (es) 2017-02-02 2021-12-16 Valfix Medical Ltd Reparación y sustitución de válvulas percutáneas
EP3579761A2 (en) 2017-02-08 2019-12-18 4Tech Inc. Post-implantation tensioning in cardiac implants
DE102017202159A1 (de) 2017-02-10 2018-08-16 Tribio Gmbh Biologische Transkatheterklappe
US10492779B2 (en) 2017-02-20 2019-12-03 Edwards Lifesciences Corporation Suturing devices for heart valve surgery
US10631968B2 (en) 2017-03-06 2020-04-28 Edwards Lifesciences Corporation Humidity-management packaging systems and methods
EP3372198B1 (en) 2017-03-06 2019-06-19 AVVie GmbH Implant for improving coaptation of an atrioventricular valve
EP3592289B1 (en) 2017-03-09 2021-07-07 Medtronic Vascular Inc. Tension management devices for stented prosthesis delivery device
US10799685B2 (en) 2017-03-09 2020-10-13 Edwards Lifesciences Corporation Expandable sheath with longitudinally extending reinforcing members
FR3063631B1 (fr) 2017-03-13 2019-03-22 Cmi'nov Dispositif de reparation des cordages de la valve mitrale d'un cœur par voie transfemorale
WO2018170149A1 (en) 2017-03-14 2018-09-20 Shape Memory Medical, Inc. Shape memory polymer foams to seal space around valves
CN113081391A (zh) 2017-03-22 2021-07-09 爱德华兹生命科学公司 用于将生物假体装置植入和固定到湿组织的系统和方法
WO2018178966A1 (en) 2017-03-27 2018-10-04 Truleaf Medical Ltd. Docking elements
DE102017002974B4 (de) 2017-03-28 2024-08-08 Immanuel Albertinen Diakonie Ggmbh Herzklappen-Implantat, geeignet für den Einsatz in der minimal-invasiven Chirurgie zur Reparatur einer Herzklappe und/oder eines Herzklappensegels am schlagenden Herzen und Herzklappen-lmplantat-System
CA3178029A1 (en) 2017-04-05 2018-10-11 Opus Medical Therapies, LLC Transcatheter atrial sealing skirt, anchor, and tether and methods of implantation
EP3606472B1 (en) 2017-04-06 2021-09-15 Harpoon Medical, Inc. Distal anchor apparatus and method of manufacturing a distal anchor
PL3558169T3 (pl) 2017-04-18 2022-04-04 Edwards Lifesciences Corporation Urządzenia do uszczelniania zastawki serca i urządzenia do ich doprowadzania
US11224511B2 (en) 2017-04-18 2022-01-18 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
EP3619136B1 (en) 2017-05-02 2021-04-21 Medtronic Vascular Inc. Packaging for dry tissue prosthetic heart valve
US10959846B2 (en) 2017-05-10 2021-03-30 Edwards Lifesciences Corporation Mitral valve spacer device
IT201700052909A1 (it) 2017-05-16 2018-11-16 Star Tric S R L Protesi articolata per valvola tricuspide o mitrale e relativo dispositivo di afferraggio
IL309520B2 (en) 2017-05-31 2026-02-01 Edwards Lifesciences Corp Sealing component for heart valve bushing
JP6736193B2 (ja) 2017-06-08 2020-08-05 ４テック インコーポレイテッド テザー停止部を有する組織アンカー
EP3417831B2 (en) 2017-06-19 2023-05-24 HVR Cardio Oy Delivery device for an annuloplasty implant
EP4122507B1 (en) 2017-06-29 2024-04-17 St. Jude Medical, Cardiology Division, Inc. Method of preparing calcification-resistant bioprosthetic heart valve
JP7143340B2 (ja) 2017-06-30 2022-09-28 ギオラ ウェイズ， 体内空間内での多次元ナビゲーション
US10786352B2 (en) 2017-07-06 2020-09-29 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
EP3648708A4 (en) 2017-07-06 2021-03-31 Edwards Lifesciences Corporation CONTROLLED DISPENSING SYSTEM AND COMPONENTS
EP3661436B1 (en) 2017-07-31 2022-06-29 Boston Scientific Scimed, Inc. Introducer system with expandable capabilities
DE202017104793U1 (de) 2017-08-09 2018-11-14 Nvt Ag Ladesystem für Herzklappenprothesen
US10973628B2 (en) 2017-08-18 2021-04-13 Edwards Lifesciences Corporation Pericardial sealing member for prosthetic heart valve
US10722353B2 (en) 2017-08-21 2020-07-28 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
IL254099B (en) 2017-08-22 2021-02-28 Geonovation Medical Tech Ltd Collapsible one-way valve bushing
EP3672532B1 (en) 2017-08-26 2022-08-03 Transmural Systems LLC Implantable cardiac pacing system
US10799356B2 (en) 2017-09-12 2020-10-13 Boston Scientific Scimed, Inc. Percutaneous papillary muscle relocation
WO2019055527A1 (en) 2017-09-13 2019-03-21 Mayo Foundation For Medical Education And Research METHODS AND DEVICES FOR ATTACHING EPICARDIC DEVICES
US10856982B2 (en) 2017-09-19 2020-12-08 St. Jude Medical, Cardiology Division, Inc. Transapical mitral valve delivery system
EP3668450B1 (en) 2017-09-22 2021-07-14 Boston Scientific Scimed, Inc. Dome structure for improved left ventricle function
US20190091013A1 (en) 2017-09-22 2019-03-28 St. Jude Medical, Cardiology Division, Inc. Prosthetic Heart Valve with Atraumatic Aortic Portion
FR3071716B1 (fr) 2017-10-04 2023-02-24 Mdb Texinov Insert textile a finalite medicale et son procede de fabrication
FR3072013B1 (fr) 2017-10-09 2019-09-27 Cmi'nov Dispositif de suture d'une prothese valvulaire cardiaque
EP3470105B1 (de) 2017-10-13 2020-04-22 BIOTRONIK SE & Co. KG Einführelement für eine medizinische einführeinrichtung
US9895226B1 (en) 2017-10-19 2018-02-20 Mitral Tech Ltd. Techniques for use with prosthetic valve leaflets
US10426473B2 (en) 2017-10-19 2019-10-01 Abbott Cardiovascular Systems Inc. System and method for plicating a heart valve
KR102367877B1 (ko) 2017-10-19 2022-02-28 상하이 한위 메디컬 테크놀로지 컴퍼니 리미티드 판막 클램핑 장치
WO2019079788A1 (en) 2017-10-20 2019-04-25 Boston Scientific Scimed, Inc. CARDIAC VALVE REPAIR IMPLANT FOR THE TREATMENT OF TRICUSPID REGURGITATION
EP3476366B1 (en) 2017-10-27 2020-12-16 Medtentia International Ltd Oy Annuloplasty implant
US10912664B2 (en) 2017-11-21 2021-02-09 Cook Medical Technologies, LLC Stent with induction responsive muscles that facilitate implantation adjustments
KR102053451B1 (ko) 2017-11-24 2020-01-08 (주) 타우피엔유메디칼 서클라지 심방 제세동장치
EP3498223A1 (en) 2017-12-13 2019-06-19 Epygon Crimping device for collapsible valves
CN108065970B (zh) 2017-12-14 2019-06-25 谭雄进 一种可多次调节的人工腱索固定组件
US11547563B2 (en) 2018-01-08 2023-01-10 Medtentia International Ltd. Oy Annuloplasty device
IT201800000671A1 (it) 2018-01-10 2019-07-10 Matteo Montorfano Dispositivo di inserimento di un filo di guida in un vaso sanguigno
IL276116B2 (en) 2018-01-19 2025-03-01 Edwards Lifesciences Corp Wrapped artificial heart valve
EP4238507A3 (en) 2018-01-27 2023-11-29 LSI Solutions, Inc. Prosthetic suturing device
DE102018102940B4 (de) 2018-02-09 2019-10-31 Francisco Javier Carrero Gomez Vorrichtung zur Prüfung der Funktion einer Aortenklappe
EP3527170B1 (en) 2018-02-20 2020-11-18 Institut National des Sciences Appliquées de Lyon Device for assisting a practitioner in adjusting the length of an artificial chordae implanted in an atrio-ventricular heart valve
WO2019165394A1 (en) 2018-02-26 2019-08-29 Boston Scientific Scimed, Inc. Embedded radiopaque marker in adaptive seal
CN112423703A (zh) 2018-03-27 2021-02-26 马杜罗探索有限责任公司 在介入治疗手术期间提供神经保护的辅助器械
FR3079404B1 (fr) 2018-03-29 2020-03-06 Electroducer Ensemble de remplacement d’une valve cardiaque avec assistance de stimulation par voie arterielle ou veineuse peripherique
US11234812B2 (en) 2018-04-18 2022-02-01 St. Jude Medical, Cardiology Division, Inc. Methods for surgical valve expansion
US11026787B2 (en) 2018-04-30 2021-06-08 St. Jude Medical, Cardiology Division, Inc. Heart valve holder
KR102771352B1 (ko) 2018-04-30 2025-02-24 에드워즈 라이프사이언시스 코포레이션 인공 이식물을 크림핑하기 위한 디바이스 및 방법
EP3790501B1 (en) 2018-05-07 2022-06-29 Medtronic Vascular, Inc. Assemblies and methods of sterilizing a wet stored implant
WO2019223975A1 (en) 2018-05-21 2019-11-28 Medtentia International Ltd Oy Annuloplasty device
WO2019226803A1 (en) 2018-05-22 2019-11-28 Boston Scientific Scimed, Inc. Percutaneous papillary muscle relocation
EP3796872B1 (en) 2018-05-23 2022-07-20 Corcym S.r.l. A device for the in-situ delivery of heart valve prostheses
CN112437649B (zh) 2018-05-23 2024-10-11 恪心有限责任公司 心脏瓣膜假体
EP3581232B1 (en) 2018-06-11 2021-02-17 Dentsply IH AB Urethral stent and bladder control assembly comprising such a urethral stent
US11357628B2 (en) 2018-08-06 2022-06-14 Thubrikar Aortic Valve, Inc. Apparatus and method for delivery of a prosthetic valve device
US20210145580A1 (en) 2018-08-07 2021-05-20 4Tech Inc. Post-implantation tensioning in cardiac implants
EP3620133A1 (en) 2018-09-07 2020-03-11 AVVie GmbH Implant for improving coaptation of an artrioventricular valve
FR3085835B1 (fr) 2018-09-13 2020-08-28 Univ Compiegne Tech Implant pour valve cardiaque
US11395738B2 (en) 2018-09-25 2022-07-26 Truleaf Medical Ltd. Docking elements
CN112888407B (zh) 2018-10-04 2024-02-23 史赛克公司 医用植入物递送系统
ES2983342T3 (es) 2018-10-10 2024-10-22 Devie Medical Gmbh Implante para el tratamiento y/o la sustitución de una válvula cardíaca inflamada, trombosada o degenerada
DE102018126828A1 (de) 2018-10-26 2020-04-30 Nvt Ag Herzklappenprothese
EP3876870B1 (en) 2018-11-08 2023-12-20 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
US20220117734A1 (en) 2018-11-29 2022-04-21 Cardiomech As Device for Heart Repair
WO2020126001A1 (de) 2018-12-20 2020-06-25 Medizinische Universität Wien Stentgraft und vorrichtung zum zuführen und setzen eines solchen stentgrafts in die aorta ascendens
CN111437065A (zh) 2019-01-17 2020-07-24 TauPNU医疗有限公司 位置可调节的三尖瓣返流手术用器械
US10898329B2 (en) 2019-01-25 2021-01-26 Edwards Lifesciences Corporation Testing apparatus for prosthetic device
CN112236189B (zh) 2019-02-26 2024-11-22 株式会社艾科纳研究所 心脏支撑网以及植入型除颤器
US11452599B2 (en) 2019-05-02 2022-09-27 Twelve, Inc. Fluid diversion devices for hydraulic delivery systems and associated methods
EP3908228B1 (en) 2020-03-17 2022-08-24 Cardiovalve Ltd. Leaflet-grouping system
WO2021195823A1 (zh) 2020-03-30 2021-10-07 乐普（北京）医疗器械股份有限公司 心脏瓣膜夹合器
US11318013B2 (en) 2020-04-21 2022-05-03 Medtronic, Inc. Compact prosthetic heart valve device
EP3912595B1 (en) 2020-05-19 2023-01-04 AVVie GmbH Implant for improving coaptation of an atrioventricular valve

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6629534B1 (en) 1999-04-09 2003-10-07 Evalve, Inc. Methods and apparatus for cardiac valve repair
US20070016286A1 (en) 2003-07-21 2007-01-18 Herrmann Howard C Percutaneous heart valve
US20110015731A1 (en) 2004-01-23 2011-01-20 Edwards Lifesciences Corporation Anatomically Approximate Prosthetic Mitral Valve
US20060241745A1 (en) 2005-04-21 2006-10-26 Solem Jan O Blood flow controlling apparatus
WO2008103722A2 (en) 2007-02-23 2008-08-28 Endovalve, Inc. Mitral valve system
WO2009134701A2 (en) 2008-05-01 2009-11-05 Edwards Lifesciences Corporation Device and method for replacing mitral valve
WO2011137531A1 (en) 2010-05-05 2011-11-10 Neovasc Inc. Transcatheter mitral valve prosthesis
US20110319989A1 (en) * 2010-05-05 2011-12-29 Neovasc, Inc. Transcatheter mitral valve prosthesis
US9125738B2 (en) 2011-01-11 2015-09-08 Hans Reiner Figulla Prosthetic valve for replacing an atrioventricular heart valve
US20130075215A1 (en) 2011-09-28 2013-03-28 Mitutoyo Corporation Constant-force device and micrometer
WO2013075215A1 (en) * 2011-11-23 2013-05-30 Neovasc Inc. Sequentially deployed transcatheter mitral valve prosthesis
US20130231735A1 (en) 2012-03-01 2013-09-05 Foundry Newco Xii, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
WO2015188066A1 (en) 2014-06-06 2015-12-10 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US20170165064A1 (en) * 2015-12-15 2017-06-15 Neovasc Tiara Inc. Transseptal delivery system
US20180116790A1 (en) 2016-11-02 2018-05-03 Edwards Lifesciences Corporation Supra and sub-annular mitral valve delivery system

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11419720B2 (en) 2010-05-05 2022-08-23 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US11737872B2 (en) 2018-11-08 2023-08-29 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
US12611303B2 (en) 2022-07-21 2026-04-28 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis

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