US20140277427A1 - Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery - Google Patents

Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery Download PDF

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Publication number
US20140277427A1
US20140277427A1 US14/197,690 US201414197690A US2014277427A1 US 20140277427 A1 US20140277427 A1 US 20140277427A1 US 201414197690 A US201414197690 A US 201414197690A US 2014277427 A1 US2014277427 A1 US 2014277427A1
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United States
Prior art keywords
frame
distal
anchors
prosthesis
proximal
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Abandoned
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US14/197,690
Inventor
J. Brent Ratz
Arshad Quadri
Luca Pesce
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Edwards Lifesciences Cardiaq LLC
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Cardiaq Valve Technologies Inc
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Priority to US14/197,690 priority Critical patent/US20140277427A1/en
Assigned to CARDIAQ VALVE TECHNOLOGIES, INC. reassignment CARDIAQ VALVE TECHNOLOGIES, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: QUADRI, ARSHAD, PESCE, LUCA, RATZ, J. BRENT
Publication of US20140277427A1 publication Critical patent/US20140277427A1/en
Assigned to EDWARDS LIFESCIENCES CARDIAQ, INC. reassignment EDWARDS LIFESCIENCES CARDIAQ, INC. MERGER AND CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: CARDIAQ VALVE TECHNOLOGIES, INC., CARDIAQ VALVE TECHNOLOGIES, INC.,, IMPALA, INC.
Assigned to EDWARDS LIFESCIENCES CARDIAQ LLC reassignment EDWARDS LIFESCIENCES CARDIAQ LLC CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: EDWARDS LIFESCIENCES CARDIAQ, INC.
Priority to US15/947,168 priority patent/US10583000B2/en
Priority to US16/783,868 priority patent/US11324591B2/en
Priority to US17/733,914 priority patent/US20220249225A1/en
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2409Support rings therefor, e.g. for connecting valves to tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418Scaffolds therefor, e.g. support stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2454Means for preventing inversion of the valve leaflets, e.g. chordae tendineae prostheses
    • A61F2/2457Chordae tendineae prostheses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008Fixation appliances for connecting prostheses to the body

Definitions

  • Certain embodiments disclosed herein relate generally to prostheses for implantation within a lumen or body cavity.
  • certain embodiments relate to expandable prostheses such as replacement heart valves, such as for the mitral valve, that are configured to atraumatically grasp intralumenal tissue.
  • Human heart valves which include the aortic, pulmonary, mitral and tricuspid valves, function essentially as one-way valves operating in synchronization with the pumping heart.
  • the valves allow blood to flow downstream, but block blood from flowing upstream.
  • Diseased heart valves exhibit impairments such as narrowing of the valve or regurgitation, which inhibit the valves' ability to control blood flow.
  • Such impairments reduce the heart's blood-pumping efficiency and can be a debilitating and life threatening condition.
  • valve insufficiency can lead to conditions such as heart hypertrophy and dilation of the ventricle.
  • extensive efforts have been made to develop methods and apparatuses to repair or replace impaired heart valves.
  • Prostheses exist to correct problems associated with impaired heart valves.
  • mechanical and tissue-based heart valve prostheses can be used to replace impaired native heart valves.
  • substantial effort has been dedicated to developing replacement heart valves, particularly tissue-based replacement heart valves that can be delivered with less trauma to the patient than through open heart surgery.
  • Replacement valves are being designed to be delivered through minimally invasive procedures and even percutaneous procedures.
  • Such replacement valves often include a tissue-based valve body that is connected to an expandable frame that is then delivered to the native valve's annulus.
  • prostheses including but not limited to replacement heart valves that can be compacted for delivery and then controllably expanded for controlled placement has proven to be particularly challenging.
  • An additional challenge relates to the ability of such prostheses to be secured relative to intralumenal tissue, e.g., tissue within any body lumen or cavity, in an atraumatic manner. Further challenges arise when trying to controllably deliver and secure such prostheses in a location such as at a native mitral valve.
  • Embodiments of the present disclosure are directed to a prosthesis, such as but not limited to a replacement heart valve. Further embodiments are directed to methods of delivering a prosthesis into a body cavity and/or securing a prosthesis to intralumenal tissue. In some embodiments, a replacement heart valve and methods for delivering a replacement heart valve to a native heart valve, such as a mitral valve, are provided.
  • a prosthesis can comprise an expandable frame, a plurality of distal anchors and a plurality of proximal anchors.
  • the anchors can extend outwardly from the frame.
  • the frame can be configured to radially expand and contract for deployment within the body cavity.
  • the frame when the frame is in an expanded configuration, can have a larger cross-sectional dimension in a middle portion of the frame and a smaller cross-sectional dimension in a proximal portion and a distal portion of the frame, wherein the middle portion is between the proximal and distal portions.
  • at least some of the anchors comprise a loop that forms an atraumatic end of a corresponding anchor.
  • a prosthesis can be configured to atraumatically grasp intralumenal tissue when deployed within a body cavity.
  • the prosthesis can comprise an expandable frame comprising a proximal end and a distal end and having a longitudinal axis extending between the proximal end and the distal end.
  • the frame can be configured to radially expand and contract for deployment within the body cavity, wherein when the frame is in an expanded configuration, the frame has a larger cross-sectional dimension in a middle portion of the frame and a smaller cross-sectional dimension in a proximal portion and a distal portion of the frame, wherein the middle portion is between the proximal and distal portions.
  • the prosthesis can also include a plurality of generally distally extending anchors extending from the proximal portion of the frame and configured so that when the frame is in an expanded configuration each distally extending anchor has an end positioned radially outward from the middle portion of the frame, and a plurality of generally proximally extending anchors extending from the distal portion of the frame and configured so that when the frame is in an expanded configuration each proximally extending anchor has an end positioned radially outward form the middle portion of the frame and axially spaced from the ends of the distally extending anchors.
  • At least some of the anchors can comprise a loop that forms an atraumatic end of the anchor
  • the frame can be configured such that radial expansion of the frame causes the ends of the plurality of distally extending anchors and the ends of the plurality of proximally extending anchors to draw closer together.
  • a prosthesis can be configured to atraumatically grasp intralumenal tissue when deployed within a body cavity.
  • the prosthesis can comprise an expandable frame, a plurality of proximal anchors each connected to the frame so that when the frame is in an expanded configuration an end of each proximal anchor is positioned radially outward from the frame and extends generally distally, and a plurality of distal anchors each connected to the frame so that when the frame is in an expanded configuration an end of each distal anchor is positioned radially outward from the frame and extends generally proximally, wherein the ends of the distal anchors are axially spaced from the ends of the proximal anchors when the frame is in an expanded configuration.
  • at least some of the anchors can comprise a looped end.
  • the anchors can comprise a loop.
  • Each loop of these later embodiments can comprise first through fourth segments and an arcuate segment.
  • the first and second segments can both extend in a first generally axial direction away from the frame.
  • the third and fourth segments can extend radially outward from the frame in a second direction generally opposite the first direction, the third segment connected to the first segment and the fourth segment connected to the second segment.
  • the arcuate segment can connect the third segment and the fourth segment that forms an atraumatic end of a corresponding anchor.
  • the frame is configured such that radial expansion of the frame causes the ends of the plurality of proximal anchors and the ends of the plurality of distal anchors to draw closer together.
  • a prosthesis can be configured to atraumatically grasp intralumenal tissue when deployed within a body cavity.
  • the prosthesis can comprise an expandable frame, a plurality of proximal anchors, and a plurality of distal anchors.
  • the expandable frame can comprise a proximal end and a distal end and having a longitudinal axis extending between the proximal end and the distal end, the frame configured to radially expand and contract for deployment within the body cavity.
  • the plurality of proximal anchors can each connect to the frame so that when the frame is in an expanded configuration an end of each proximal anchor is positioned radially outward from the frame and extends generally distally.
  • the plurality of distal anchors can each connect to the frame so that when the frame is in an expanded configuration an end of each distal anchor is positioned radially outward from the frame and extends generally proximally, wherein the ends of the distal anchors are axially spaced from the ends of the proximal anchors when the frame is in an expanded configuration.
  • At least some of the anchors can comprise a loop.
  • Each of the anchors that comprises a loop can comprise at least a first segment extending in a first generally axial direction away from the frame, and a second segment and a third segment extending radially outward from the frame in a second direction generally opposite the first direction and coming together in an atraumatic end.
  • the frame can be configured such that radial expansion of the frame causes the ends of the plurality of proximal anchors and the ends of the plurality of distal anchors to draw closer together.
  • a prosthesis can be configured to atraumatically grasp intralumenal tissue when deployed within a body cavity.
  • the prosthesis can comprise an expandable frame comprising a proximal end and a distal end and having a longitudinal axis extending between the proximal end and the distal end, the frame configured to radially expand and contract for deployment within the body cavity, a plurality of proximal anchors each connected to the frame so that when the frame is in an expanded configuration an end of each proximal anchor is positioned radially outward from the frame and extends generally distally, and a plurality of distal anchors each connected to the frame so that when the frame is in an expanded configuration an end of each distal anchor is positioned radially outward from the frame and extends generally proximally, wherein the ends of the distal anchors are axially spaced from the ends of the proximal anchors when the frame is in an expanded configuration.
  • each loop can comprise first through fourth segments and an arcuate segment.
  • the first and second segments can both extend in a first generally axial direction away from the frame.
  • the third and fourth segments can extend radially outward from the frame in a second direction generally opposite the first direction, the third segment connected to the first segment and the fourth segment connected to the second segment.
  • the arcuate segment can connect the third segment and the fourth segment that forms an atraumatic end of a corresponding anchor.
  • the frame can be configured such that radial expansion of the frame causes the ends of the plurality of proximal anchors and the ends of the plurality of distal anchors to draw closer together.
  • a method of delivering a replacement valve to a native mitral valve can comprise one or more of the following steps. Delivering a replacement valve mounted on a delivery device to the native mitral valve annulus while the replacement valve is in a radially compacted state, the replacement valve comprising a radially expandable frame comprising a proximal end, a distal end, a plurality of distal anchors extending generally proximally from the frame, and a plurality of proximal anchors extending generally distally from the frame.
  • proximal anchors upon further release of the replacement valve from the delivery device move into engagement with tissue on an atrial side of the native valve annulus while the distal anchors provide tension on the chordae tendineae.
  • FIG. 1A is a side view of an embodiment of a prosthesis.
  • FIG. 1B is a flat pattern view of the prosthesis of FIG. 1A .
  • FIG. 2A is a side view of an embodiment of a prosthesis.
  • FIG. 2B is a flat pattern view of the prosthesis of FIG. 2A .
  • FIG. 3A is a side view of an embodiment of a prosthesis.
  • FIG. 3B is a flat pattern view of the prosthesis of FIG. 3A .
  • FIG. 4 is a side view of an embodiment of a prosthesis.
  • FIG. 5 is a side view of an embodiment of a prosthesis.
  • FIG. 6A is a side view of an embodiment of a prosthesis configured as a replacement heart valve.
  • FIG. 6B is a bottom view of the prosthesis similar of FIG. 6A .
  • FIG. 7 is a side view of an embodiment of a prosthesis configured as a replacement heart valve.
  • FIG. 8A is a side view of an embodiment of a prosthesis.
  • FIG. 8B is a detail view of a portion of the prosthesis of FIG. 8A .
  • FIG. 9A is a side view of an embodiment of a prosthesis.
  • FIG. 9B is a bottom view of the prosthesis of FIG. 9A , configured as a replacement heart valve.
  • FIG. 10 is a schematic representation of a prosthesis positioned within the heart.
  • FIG. 10A is a detail schematic representation of the prosthesis positioned within the heart of FIG. 10 .
  • the illustrated prosthesis 10 includes a frame 20 that may be self-expanding or balloon expandable.
  • the prosthesis may further include a replacement valve that can be designed to replace a damaged or diseased native heart valve such as a mitral valve.
  • the replacement valve is not shown in this embodiment as to more clearly illustrate features of the frame 20 , though it will be understood that a replacement valve is not required as part of the prosthesis.
  • only a front portion of the frame 20 is shown for further ease of illustration.
  • the frame 20 can be made of many different materials, but is preferably made from metal.
  • the frame 20 can be made from a shape memory material, such as nitinol.
  • a wire frame or a metal tube can be used to make the frame.
  • the wire frame of a metal tube can be cut or etched to remove all but the desired metal skeleton.
  • a metal tube is laser cut in a repeating pattern to form the frame.
  • FIG. 1B illustrates the flat cut pattern of the frame shown in FIG. 1A .
  • the flat pattern can be cut from a metal tube and then the tube can be bent and expanded to the shape shown in FIG. 1A .
  • the frame 20 can further be expanded and/or compressed and/or otherwise worked to have the desired shape or shapes, such as for introduction and implantation.
  • the frame when in an expanded configuration, such as in a fully expanded configuration, has a bulbous or slightly bulbous shape, with a middle portion being larger than the proximal 32 and distal 34 ends.
  • the inside diameter of the both ends can be the same, or it can be bigger on one end than the other, while still having a middle portion larger than both the proximal and distal ends.
  • the effective diameter of the distal frame end is smaller than the effective diameter of the middle portion.
  • the bulbous shape of the frame can advantageously allow the frame to engage a native valve annulus or other body cavity, while spacing the inlet and outlet from the heart or vessel wall.
  • the frame may not have a bulbous portion, and can have substantially the same outer dimension along its entire length, or it may have one end larger than the other end.
  • the prosthesis 10 and frame 20 may be similar to the replacement heart valves and associated frames disclosed in U.S. Pat. No. 8,403,983 and U.S. Publication Nos. 2010/0298931, 2011/0313515 and 2012/0078353 the entireties of each of which are hereby incorporated by reference and made a part of this specification. This is inclusive of the entire disclosure and is not in any way limited to the disclosure of the replacement heart valves and associated frames.
  • FIG. 1 illustrates the frame in an expanded configuration with a number of longitudinal struts 12 and undulating struts 14 , with cells defined by the open spaces between the struts.
  • the longitudinal struts may be arranged so that they are parallel or generally or substantially parallel to a longitudinal axis of the frame.
  • the longitudinal axis of the frame may be defined as the central axis that extends through the center of the frame between the proximal 32 and distal 34 ends.
  • Any number of configurations of struts can be used, such as the rings of undulating struts shown forming chevrons and diamonds, but also ovals, curves, and various other shapes.
  • the illustrated embodiment includes two rings, or rows of chevrons shown in portion 16 and two rows of diamond-shaped cells shown in portion 18 .
  • the frame 20 has a non-foreshortening portion 16 and a foreshortening portion 18 . These portions can be defined by the frame 20 and the positioning of various types of struts along the frame 20 .
  • FIG. 1 it can be seen that the longitudinal struts 12 span the length of the non-foreshortening portion 16 , while undulating struts 14 form the foreshortening portion 18 .
  • the struts 14 become more parallel with respect to the longitudinal axis of the frame, causing an outer diameter of the frame to decrease and the longitudinal length of the frame to increase in the foreshortening portion 18 .
  • the longitudinal length of the frame can decrease in the foreshortening portion 18 . But, the frame length does not substantially change length in the non-foreshortening portion 16 .
  • Foreshortening of the frame 20 can be used to engage and secure the prosthesis to intralumenal tissue in a body cavity, for example tissue at or adjacent a native valve, such as a native valve annulus and/or leaflets.
  • Opposing anchors 22 , 24 can be constructed on the frame 20 so that portions of the anchors, such as tips or ends 26 , 28 , move closer together as the frame foreshortens. As one example, this can allow the anchors 22 , 24 to grasp tissue on opposite sides of the native mitral annulus to thereby secure the prosthesis at the mitral valve.
  • the anchors 22 , 24 and anchor tips 26 , 28 can be located anywhere along the frame 20 just so long as at least one of the anchors is either connected to the foreshortening portion 18 or the foreshortening portion is positioned between the anchors so that a portion of the anchors will be move closer together with expansion of the frame.
  • the anchors 24 are connected to the foreshortening portion 18 .
  • the foreshortening portion can also be positioned anywhere along the frame, though it is shown towards the distal end 34 .
  • both of the anchor tips 26 , 28 are located in the foreshortening portion 18 .
  • the foreshortening portion 18 may extend the entire length of the frame, such that there is no non-foreshortening portion 16 .
  • each of the anchors 22 , 24 is positioned or extends generally radially outwardly from the frame 20 so that the anchor tips 26 , 28 are generally spaced away or radially outward from the rest of the frame 20 .
  • the anchor tips may be located radially outward from the middle portion of the frame, with the tips 26 and 28 being axially spaced from one another.
  • all or part of the structure connected to the anchor tip and extending radially from the frame, including one or more rings and/or struts can be considered part of the anchor.
  • the anchors can include a base located on the anchor on a side opposite the tip. The base can be for example where the anchor begins to extend from or away from the frame 20 .
  • proximal anchors 22 are shown having first 36 and second 38 struts forming a chevron and connected to longitudinal struts 12 at a base of the anchor.
  • the first and second struts of the anchor 22 are bent at the base so that the anchor 22 extends radially outwardly from the frame as it extends generally distally towards the tip 26 .
  • the first and second struts can be connected to each other at a radially outward location to form an outwardly extending loop, and in some embodiments, the first and second struts can be joined at a third strut 40 that continues to extend outwardly and/or generally distally.
  • the third strut 40 is a short strut.
  • the anchor also includes an eyelet 46 .
  • the eyelet is located at the distal end 26 , though the eyelet can be positioned in other locations along the anchor 22 .
  • the tips 26 of the proximal anchors may extend distally and be parallel or substantially parallel with the longitudinal axis of the frame, or as illustrated in FIG. 1A , the tips 26 may extend generally distally but still radially outwardly inclined or at an acute angle relative to the longitudinal axis of the frame.
  • the distal anchors 24 are shown having looped ends 48 .
  • the looped ends can be larger near the tip to form a type of elongated teardrop.
  • the tips 28 may be substantially flat.
  • the looped end may assist the frame in not getting caught up on structures at or near the treatment location.
  • each loop can be configured so that when the frame is deployed in-situ and expands, the movement of each loop from a delivered position to a deployed position can avoids getting caught on the papillary muscles.
  • Each distal anchor 24 is connected to the frame at a base 42 .
  • the base of the distal anchor may be at a location where the corners of adjacent cells meet, such that the base is proximal to the distal end 34 of the frame.
  • the base of the distal anchor may be at a distal most corner of a cell, which corresponds to a distal most point on the frame
  • the distal anchors as illustrated extend from the base 42 generally distally before bending back around in an arcuate segment where the distal anchor extends generally proximally and radially outwardly from the frame.
  • the anchors 24 may also generally distally and radially inwardly with respect to the frame such that the distal most point on the prosthesis has a smaller inside diameter than where the base 42 connects to the frame.
  • the inside diameter at the distal most can be the same or substantially the same as the inside diameter of the proximal end, or may be smaller.
  • the anchor as illustrated is bent around about 180 degrees so that the tip 28 extends in the opposite, proximal direction, which may be parallel or substantially parallel to the longitudinal axis of the frame.
  • the distal anchors 24 are bent further inward such that the ends of the anchors point proximally and are generally parallel with the longitudinal axis of the frame.
  • the tip 28 may extend generally proximally but still extend radially outwardly inclined or at an acute angle relative to the longitudinal axis of the frame
  • each of the anchors can extend radially outwardly from the frame at an anchor base and terminate at an anchor tip.
  • the anchors can be connected to the frame at one of many different locations including apices, junctions, other parts of struts, etc.
  • the anchors can comprise first, second, third, or more spaced apart bending stages along the length of each anchor.
  • the anchors can also extend either distally or proximally before and/or after one or more of the bending stages. A portion of the anchor may extend with the frame before or after any bending stages.
  • FIG. 1A-B there are twelve distal anchors and twelve proximal anchors. In some embodiments there may be 6 anchors on one side and 12 on the other. Some embodiments may include different numbers of anchors. In addition, the distal and proximal anchors may be aligned so the tips point generally towards each other, or they may be spaced so that the tips point between two tips on the opposite side, as is illustrated in FIGS. 1A-B .
  • the anchor tips 26 and 28 as described above advantageously provide atraumatic surfaces that may be used to grasp intralumenal tissue without causing unnecessary or undesired trauma to tissue.
  • the proximal anchors tips 26 and distal anchor tips 28 may form flat, substantially flat, curved or other non-sharp surfaces to allow the tips to engage and/or grasp tissue, without necessarily piercing or puncturing through tissue.
  • FIGS. 2A-3B show prostheses similar to that of FIGS. 1A-B with two different styles of distal anchors 24 .
  • the looped end 48 ′ of the distal anchor is generally more elliptical with a curved tip as compared to the elongated teardrop shape of looped end 48 of FIGS. 1A-B . Otherwise the shape is substantially the same.
  • the distal anchors 24 are looped anchors rather than having looped ends.
  • the looped anchor has a first base 42 and a second base 44 connected to the frame, wherein the first and second bases are at opposite corners of the same cell. Alternatively, the first and second bases may be located at the distal most corners of adjacent cells.
  • the distal anchors 24 extends generally distally from the frame at the first base 42 but then is bent back around and begins to extend outwardly from the frame in a generally proximal direction. The distal anchor 24 then repeats this configuration in reverse towards the second base 44 such that the two sides of the looped anchor are mirror images of one another. It will be understood that the looped anchor can have other configurations and that it may not be symmetrical.
  • the tips 28 of the distal anchors are circumferentially aligned with the tips 26 of the proximal anchors, though in other embodiments, the tips 28 of the distal anchors may be circumferentially staggered between the tips 26 of the proximal anchors.
  • adjacent distal anchors 26 are spaced apart by one cell, though in other embodiments, adjacent distal anchors may be provided on adjacent cells.
  • the illustrated looped distal anchor of FIGS. 3A-B is made up of the following segments.
  • the first segment 50 extends generally longitudinally with the frame, extending distally or generally distally (e.g., slightly radially inward) with the frame.
  • the strut is then bent so that a second segment 52 extends generally parallel with an adjacent undulating strut 14 .
  • the strut is then bent so that a third segment 54 begins to extend generally longitudinally and distally or generally distally, and then is bent back around to point in generally the opposite direction (e.g., in a proximal direction parallel or generally parallel with the longitudinal axis of the frame).
  • the third segment 54 ends in the rounded tip 28 and then the anchor strut repeats to form the mirror image.
  • the third segment 54 may first extend radially outward at an acute angle relative to the longitudinal axis before bending into a portion that extends parallel or substantially parallel to the longitudinal axis.
  • the paired third segments 54 extend parallel or generally parallel with one another from the second segment to the tip, though they may also move slightly towards or away from each other in some embodiments.
  • FIG. 4 shows a prosthesis similar to FIGS. 3A-B that also has looped distal anchors.
  • the first segment 50 extends longitudinally in a distal direction from the frame and the strut is bent back on itself to point generally in the opposite (e.g., proximal) direction.
  • the second segment is bent inward before extending parallel or generally parallel with its mirror image on the other side forming a nose and wing configuration similar to the shape of certain bicycle seats.
  • the proximal anchors 22 also have an elongated third strut 40 .
  • the proximal anchor 22 is shown having first 36 and second 38 struts forming a chevron and connected to longitudinal struts 12 at a base of the anchor.
  • the first and second struts of the anchor 22 are bent at the base so that the anchor 22 extends radially outwardly from the frame as it extends towards the tip 26 .
  • the first and second struts join at a third strut 40 that continues to extend outwardly and is then bent such that the tip points distally and extends in a manner parallel or generally parallel with the longitudinal axis of the frame.
  • the proximal anchor may or may not include an eyelet 46 along its length.
  • the distal tip of the proximal anchors may have an atraumatic surface, such as an enlarged circular or curved end as illustrated.
  • the distal anchors 24 may have tips 28 that are positioned radially outward of the tips 26 of the proximal anchors 22 .
  • Other embodiments may have the tips 26 being positioned outward of the tips 28 .
  • Such configurations are also possible with the other frames and prostheses described elsewhere herein.
  • FIG. 5 illustrated an embodiment similar to the prosthesis of FIG. 4 with twelve distal anchors instead of six. Because of this change, in one embodiment two anchors share the first segment 50 where the anchor base 42 , 44 is connected to the frame. As illustrated, each of the proximal and distal anchors may be circumferentially aligned with each other, and each of the distal anchors corresponds to one of the cells
  • a prosthesis can include one or more of a valve 60 , a skirt 70 and a support band 80 .
  • the prosthesis can be a replacement heart valve similar to that and including features similar to those disclosed in U.S. patent application Ser. Nos. 13/165,721, filed Jun. 21, 2011, published as U.S. 2011/0313515; and 13/244,080, filed Sep. 23, 2011, published as 2012/0078353.
  • the entire contents of both applications are hereby incorporated by reference herein and made a part of this specification. This is inclusive of the entire disclosure and is not in any way limited to the disclosure of the replacement heart valve.
  • the valve 60 can be a replacement heart valve which includes a plurality of valve leaflets 62 .
  • the plurality of valve leaflets 62 can function in a manner similar to the natural mitral valve, or to other valves in the vascular system.
  • the plurality of valve leaflets 62 can open in a first position and then engage one another to close the valve in a second position.
  • the plurality of valve leaflets 62 can be made to function as a one way valve such that flow in one direction opens the valve and flow in a second direction opposite the first direction closes the valve.
  • the replacement heart valve 60 can be constructed so as to open naturally with the beating of the heart. For example, the plurality of valve leaflets 62 can open during diastole and close during systole.
  • the leaflets 62 can be coupled to a skirt 70 .
  • the proximal ends of the leaflets 62 can be connected to a proximal end of the skirt 70 .
  • the skirt 70 can be used to at least partially control how fluid flows through and/or around the valve 60 .
  • the skirt 70 can surround at least a portion of the valve and be connected to the valve leaflets 62 .
  • the skirt 70 can form an inner wall connected to and positioned within the frame 20 .
  • the skirt 70 can also be made to move with the foreshortening portion 18 of the frame 20 .
  • the skirt 70 can extend the length of the frame 20 or it can extend along only part of the length of the frame 20 .
  • the ends of the heart valve 60 can coincide with ends of the skirt 70 .
  • one or more of the ends of the frame 20 can coincide with the ends of the skirt 70 .
  • the proximal end of the skirt 70 and heart valve 60 are sewn together.
  • the skirt 70 can not only extend to the distal end of the frame 20 but can also extend to the outside of the frame and is shown wrapped around each of the distal anchors 24 .
  • the skirt 70 may extend along the length of the leaflets 62 , but is not connected to them. In the illustrated embodiments, the skirt 70 is attached to the frame 20 and the leaflets 62 are attached to the skirt 70 .
  • the skirt 70 can be constructed in multiple different ways.
  • the skirt 70 can be made of knit polyester or another stretchable or flexible fabric.
  • the skirt 70 is made from a material that is more flexible than the valve leaflet material.
  • the distal and/or proximal end of the skirt 70 can be straight, curved, or have any other desired configuration.
  • the skirt 70 is shown with undulations patterned to generally correspond to the undulations at the distal end 34 of the frame 20 . It can be seen that the skirt 70 wraps around the struts at the distal end.
  • the skirt 70 can be formed of one piece or multiple pieces.
  • the skirt 70 attached to the valve 60 can be one piece and then each distal anchor can be covered by a separate piece of material of the skirt 70 .
  • the anchors may remain uncovered, or only a portion may be covered.
  • skirt 70 another embodiment of the skirt 70 is shown.
  • the skirt extends past the frame and is then wrapped around it.
  • the skirt 70 extends from the inside of the frame 20 to the outside of the frame.
  • the skirt can extend completely around the frame for 1 ⁇ 4, 1 ⁇ 3, 1 ⁇ 2, or more of the length of the distal anchors.
  • the skirt can also cover the distal anchors 24 .
  • the skirt is a one piece skirt, but it will be understood that the skirt can be made of multiple pieces.
  • the skirt 70 and particularly portions that cover the distal anchors 24 , can beneficially be used to help prevent leakage of blood flow around the heart valve.
  • the skirt can encourage tissue in-growth between the skirt and the natural tissue. This may further help to prevent leakage of blood flow around the heart valve.
  • the prosthesis 10 can also include a support band 80 as is shown in FIGS. 6A-7 .
  • the support band 80 may be placed or positioned around or within the frame 20 at the proximal end 32 .
  • the support band 80 can be used to reinforce and/or constrain the frame 20 .
  • the support band 80 can help to control the expansion of the frame 20 from the compacted to the expanded state.
  • the support band 80 can also be used to reduce the amount of motion that occurs at the proximal end 32 after the prosthesis 10 has been implanted at the mitral heart valve or other location.
  • the support band 80 may comprise a polyester fabric band.
  • the support band 80 may comprise a no-stretch or limited stretch material.
  • the support band 80 is not made of an elastic material or a material known to have high elasticity.
  • the support band 80 is made from a material that is less flexible than the valve skirt material and/or the valve leaflet material.
  • the distal and proximal ends of the support band 80 can be straight, curved, undulating with the undulations of frame, or any other desired configuration.
  • the support band 80 can be connected to the valve frame with a plurality of stitches, loops, knots, staples, or other types of connections.
  • the frame 20 can be sandwiched between two sides or layers of the support band 80 .
  • the support band 80 is a single layer positioned within and attached to the frame 20 with a plurality of stitches around one or more of the longitudinal and/or undulating struts.
  • the support band 80 can be attached to the proximal end of the valve skirt 40 .
  • FIGS. 8A-B show a prosthesis similar to that of FIG. 4 with a different style and configuration of distal anchor 24 .
  • the distal anchors are shorter than and spaced radially inward from the distal anchors of FIG. 4 .
  • the distal anchors 24 are not positioned as far radially outward as the proximal anchors, and the tips 28 may be positioned radially inward of the tips 26 .
  • such a configuration may be advantageous in positioning and securing the prosthesis in a mitral valve or other body location.
  • the distal anchors 24 may comprise loops as described above, having a curved or arcuate atraumatic tip to minimize damage to body tissue.
  • FIGS. 9A-B show an embodiment of a prosthesis where the distal anchors do not comprise loops, but instead comprise single struts each extending distally from the corners where adjacent cells meet.
  • these anchors may first extend distally or generally distally, and may further extend radially inward, before bending around to extend proximally or generally proximally, such as at an acute angle relative to the longitudinal axis of the frame.
  • the tips 28 of the anchors may comprise an atraumatic surface, such as a flattened or curved enlarged tip. As illustrated, the tips 28 may be circumferentially staggered between tips 26 of the proximal anchors 22 , as best shown in FIG. 9B .
  • FIG. 9B also shows the frame 20 having a valve 60 and skirt 70 attached as described above.
  • any of the prostheses 10 described above may be deployed into a heart valve annulus, and positioned when compacted so that the anchor tips 26 , 28 of the opposing anchors 22 , 24 are disposed on opposite sides of the native annulus 88 as shown in FIGS. 10 and 10A .
  • the opposing anchors are drawn closer together so as to grasp tissue on opposite sides of the native annulus 88 and securely hold the replacement heart valve 10 in position.
  • the replacement heart valve 10 can be held securely in position without requiring a substantial radial force against the native annulus. Because the anchor tips are preferably atraumatic, the grasping or engaging of tissue by the prosthesis minimizes damage to the native tissue.
  • the foreshortening portion 18 can be used to move the anchor tips 26 , 28 closer together as the replacement heart valve 10 moves to the expanded position to thereby engage the native valve annulus.
  • the prosthesis can be deployed into a heart valve or otherwise deployed in manners similar to those described with respect to a replacement heart valve in U.S. Publication No. 2010/0298931 and 2012/0078353 the entireties of each of which are hereby incorporated by reference and made a part of this specification. This is inclusive of the entire disclosure and is not in any way limited to the disclosure related to deployment of a replacement heart valve.
  • FIGS. 10 and 10A show a schematic representation of the replacement heart valve 10 installed in a human heart 84 .
  • the heart is shown in cross-section, and represents typical anatomy, including a left atrium 78 and left ventricle 86 .
  • the left atrium 78 and left ventricle 86 communicate with one another through a mitral annulus 88 .
  • Also shown schematically is a native anterior mitral leaflet 90 having chordae tendineae 92 that connect a downstream end of the anterior mitral leaflet 90 and to the left ventricle 86 .
  • a method is provided of delivering a replacement valve to a native mitral valve and atraumatically securing the replacement valve relative to the native mitral valve annulus 88 .
  • the replacement valve can be mounted on a delivery device and delivered to the native mitral valve annulus while the replacement valve is in a radially compacted state.
  • the replacement valve may be positioned so that the ends or tips of the distal anchors are on a ventricular side of the native leaflets 90 beyond a location where chordae tendineae 92 connect to free ends of the native leaflets. At least a portion of the replacement valve can be released from the delivery device to thereby expand the distal anchors radially outwardly.
  • the distal anchors may extend between at least some of the chordae.
  • the distal anchors (along with the frame) can be moved toward the ventricular side of the native valve annulus with the distal anchors extending between at least some of the chordae tendineae to provide tension on the chordae tendineae.
  • the replacement valve With tension provided on the chordae tendineae, the replacement valve can be further released from the delivery device to thereby expand the proximal anchors radially outwardly.
  • the proximal anchors upon further release of the replacement valve from the delivery device can move into engagement with tissue on an atrial side of the native valve annulus, such as with the atrial side of the native valve annulus.
  • the method just described may utilize any of the prostheses herein described, but may be particularly suitable for the prosthesis of FIGS. 8A-8B where the ends of the distal anchors are not positioned as far out radially as the ends of the proximal anchors when the frame is expanded.
  • the distal anchors may have a suitable length for extending between and providing tension on the chordae tendineae, but need not and may not in some embodiments engage tissue with the tips 28 .
  • the some or all of the distal anchors remain spaced from tissue on the ventricular side of the native valve annulus after delivery and expansion.
  • the interaction between the distal anchors and the chordae tendineae may therefore be sufficient to secure the distal end of the prosthesis, while the engagement of the proximal anchors with tissue on the atrial side of the native valve annulus will help further secure and orient the prosthesis
  • the distal anchors may comprise loops, such as any of the looped structures previously described.
  • the distal anchors may also be covered with a resilient material such as described above for the skirt 70 that promotes tissue growth with adjacent body tissue. Such material may also be useful to prevent paravalvular leakage.
  • the atraumatic distal anchors may advantageously prevent snagging of the prosthesis on internal structures, such as the papillary muscles.

Abstract

A prosthesis can comprise an expandable frame, a plurality of distal anchors and a plurality of proximal anchors. The anchors can extend outwardly from the frame. The frame can be configured to radially expand and contract for deployment within a body cavity. The frame and anchors can have one of many different shapes and configurations. For example, when the frame is in an expanded configuration, the frame can have a larger cross-sectional dimension in a middle portion of the frame and a smaller cross-sectional dimension in a proximal portion and a distal portion of the frame, wherein the middle portion is between the proximal and distal portions. As another example, the anchors can have looped ends, the entire anchor may loop out from the frame.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • This application claims the benefit of priority to U.S. Provisional Appl. Nos. 61/782,707, filed Mar. 14, 2013. The entire contents of the above application(s) is/are hereby incorporated by reference and made a part of this specification. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57.
  • BACKGROUND OF THE INVENTION
  • 1. Field of the Invention
  • Certain embodiments disclosed herein relate generally to prostheses for implantation within a lumen or body cavity. In particular, certain embodiments relate to expandable prostheses such as replacement heart valves, such as for the mitral valve, that are configured to atraumatically grasp intralumenal tissue.
  • 2. Description of the Related Art
  • Human heart valves, which include the aortic, pulmonary, mitral and tricuspid valves, function essentially as one-way valves operating in synchronization with the pumping heart. The valves allow blood to flow downstream, but block blood from flowing upstream. Diseased heart valves exhibit impairments such as narrowing of the valve or regurgitation, which inhibit the valves' ability to control blood flow. Such impairments reduce the heart's blood-pumping efficiency and can be a debilitating and life threatening condition. For example, valve insufficiency can lead to conditions such as heart hypertrophy and dilation of the ventricle. Thus, extensive efforts have been made to develop methods and apparatuses to repair or replace impaired heart valves.
  • Prostheses exist to correct problems associated with impaired heart valves. For example, mechanical and tissue-based heart valve prostheses can be used to replace impaired native heart valves. More recently, substantial effort has been dedicated to developing replacement heart valves, particularly tissue-based replacement heart valves that can be delivered with less trauma to the patient than through open heart surgery. Replacement valves are being designed to be delivered through minimally invasive procedures and even percutaneous procedures. Such replacement valves often include a tissue-based valve body that is connected to an expandable frame that is then delivered to the native valve's annulus.
  • Development of prostheses including but not limited to replacement heart valves that can be compacted for delivery and then controllably expanded for controlled placement has proven to be particularly challenging. An additional challenge relates to the ability of such prostheses to be secured relative to intralumenal tissue, e.g., tissue within any body lumen or cavity, in an atraumatic manner. Further challenges arise when trying to controllably deliver and secure such prostheses in a location such as at a native mitral valve.
  • SUMMARY OF THE INVENTION
  • Embodiments of the present disclosure are directed to a prosthesis, such as but not limited to a replacement heart valve. Further embodiments are directed to methods of delivering a prosthesis into a body cavity and/or securing a prosthesis to intralumenal tissue. In some embodiments, a replacement heart valve and methods for delivering a replacement heart valve to a native heart valve, such as a mitral valve, are provided.
  • In some embodiments a prosthesis can comprise an expandable frame, a plurality of distal anchors and a plurality of proximal anchors. The anchors can extend outwardly from the frame. The frame can be configured to radially expand and contract for deployment within the body cavity. In some embodiments, when the frame is in an expanded configuration, the frame can have a larger cross-sectional dimension in a middle portion of the frame and a smaller cross-sectional dimension in a proximal portion and a distal portion of the frame, wherein the middle portion is between the proximal and distal portions. In some embodiments, at least some of the anchors comprise a loop that forms an atraumatic end of a corresponding anchor.
  • In some embodiments, a prosthesis can be configured to atraumatically grasp intralumenal tissue when deployed within a body cavity. The prosthesis can comprise an expandable frame comprising a proximal end and a distal end and having a longitudinal axis extending between the proximal end and the distal end. The frame can be configured to radially expand and contract for deployment within the body cavity, wherein when the frame is in an expanded configuration, the frame has a larger cross-sectional dimension in a middle portion of the frame and a smaller cross-sectional dimension in a proximal portion and a distal portion of the frame, wherein the middle portion is between the proximal and distal portions. The prosthesis can also include a plurality of generally distally extending anchors extending from the proximal portion of the frame and configured so that when the frame is in an expanded configuration each distally extending anchor has an end positioned radially outward from the middle portion of the frame, and a plurality of generally proximally extending anchors extending from the distal portion of the frame and configured so that when the frame is in an expanded configuration each proximally extending anchor has an end positioned radially outward form the middle portion of the frame and axially spaced from the ends of the distally extending anchors. At least some of the anchors can comprise a loop that forms an atraumatic end of the anchor The frame can be configured such that radial expansion of the frame causes the ends of the plurality of distally extending anchors and the ends of the plurality of proximally extending anchors to draw closer together.
  • A prosthesis according to certain embodiments can be configured to atraumatically grasp intralumenal tissue when deployed within a body cavity. The prosthesis can comprise an expandable frame, a plurality of proximal anchors each connected to the frame so that when the frame is in an expanded configuration an end of each proximal anchor is positioned radially outward from the frame and extends generally distally, and a plurality of distal anchors each connected to the frame so that when the frame is in an expanded configuration an end of each distal anchor is positioned radially outward from the frame and extends generally proximally, wherein the ends of the distal anchors are axially spaced from the ends of the proximal anchors when the frame is in an expanded configuration. In some embodiments, at least some of the anchors can comprise a looped end.
  • Alternatively, or in addition, in some embodiments, at least some of the anchors can comprise a loop. Each loop of these later embodiments can comprise first through fourth segments and an arcuate segment. The first and second segments can both extend in a first generally axial direction away from the frame. The third and fourth segments can extend radially outward from the frame in a second direction generally opposite the first direction, the third segment connected to the first segment and the fourth segment connected to the second segment. The arcuate segment can connect the third segment and the fourth segment that forms an atraumatic end of a corresponding anchor. In some embodiments, the frame is configured such that radial expansion of the frame causes the ends of the plurality of proximal anchors and the ends of the plurality of distal anchors to draw closer together.
  • In some embodiments, a prosthesis can be configured to atraumatically grasp intralumenal tissue when deployed within a body cavity. The prosthesis can comprise an expandable frame, a plurality of proximal anchors, and a plurality of distal anchors. The expandable frame can comprise a proximal end and a distal end and having a longitudinal axis extending between the proximal end and the distal end, the frame configured to radially expand and contract for deployment within the body cavity. The plurality of proximal anchors can each connect to the frame so that when the frame is in an expanded configuration an end of each proximal anchor is positioned radially outward from the frame and extends generally distally. The plurality of distal anchors can each connect to the frame so that when the frame is in an expanded configuration an end of each distal anchor is positioned radially outward from the frame and extends generally proximally, wherein the ends of the distal anchors are axially spaced from the ends of the proximal anchors when the frame is in an expanded configuration. At least some of the anchors can comprise a loop. Each of the anchors that comprises a loop can comprise at least a first segment extending in a first generally axial direction away from the frame, and a second segment and a third segment extending radially outward from the frame in a second direction generally opposite the first direction and coming together in an atraumatic end. The frame can be configured such that radial expansion of the frame causes the ends of the plurality of proximal anchors and the ends of the plurality of distal anchors to draw closer together.
  • According to some embodiments a prosthesis can be configured to atraumatically grasp intralumenal tissue when deployed within a body cavity. The prosthesis can comprise an expandable frame comprising a proximal end and a distal end and having a longitudinal axis extending between the proximal end and the distal end, the frame configured to radially expand and contract for deployment within the body cavity, a plurality of proximal anchors each connected to the frame so that when the frame is in an expanded configuration an end of each proximal anchor is positioned radially outward from the frame and extends generally distally, and a plurality of distal anchors each connected to the frame so that when the frame is in an expanded configuration an end of each distal anchor is positioned radially outward from the frame and extends generally proximally, wherein the ends of the distal anchors are axially spaced from the ends of the proximal anchors when the frame is in an expanded configuration. At least some of the anchors can comprise a loop and each loop can comprise first through fourth segments and an arcuate segment. The first and second segments can both extend in a first generally axial direction away from the frame. The third and fourth segments can extend radially outward from the frame in a second direction generally opposite the first direction, the third segment connected to the first segment and the fourth segment connected to the second segment. The arcuate segment can connect the third segment and the fourth segment that forms an atraumatic end of a corresponding anchor. The frame can be configured such that radial expansion of the frame causes the ends of the plurality of proximal anchors and the ends of the plurality of distal anchors to draw closer together.
  • Methods of delivering a prosthesis and/or securing the prosthesis to intralumenal tissue are also provided. In one embodiment, a method of delivering a replacement valve to a native mitral valve can comprise one or more of the following steps. Delivering a replacement valve mounted on a delivery device to the native mitral valve annulus while the replacement valve is in a radially compacted state, the replacement valve comprising a radially expandable frame comprising a proximal end, a distal end, a plurality of distal anchors extending generally proximally from the frame, and a plurality of proximal anchors extending generally distally from the frame. Positioning the replacement valve so that ends of the distal anchors are on a ventricular side of the native leaflets beyond a location where chordae tendineae connect to free ends of the native leaflets. Releasing at least a portion of the replacement valve from the delivery device to thereby expand the distal anchors radially outwardly to a first radial dimension. Moving the ends of the distal anchors toward the ventricular side of the native valve annulus with the distal anchors extending between at least some of the chordae tendineae to provide tension on the chordae tendineae. Further releasing the replacement valve from the delivery device to thereby expand the proximal anchors radially outwardly to a second radial dimension greater than the first radial dimension, wherein the proximal anchors upon further release of the replacement valve from the delivery device move into engagement with tissue on an atrial side of the native valve annulus while the distal anchors provide tension on the chordae tendineae.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • These and other features, aspects and advantages are described below with reference to the drawings, which are intended to illustrate but not to limit the invention. In the drawings, like reference characters denote corresponding features consistently throughout similar embodiments.
  • FIG. 1A is a side view of an embodiment of a prosthesis.
  • FIG. 1B is a flat pattern view of the prosthesis of FIG. 1A.
  • FIG. 2A is a side view of an embodiment of a prosthesis.
  • FIG. 2B is a flat pattern view of the prosthesis of FIG. 2A.
  • FIG. 3A is a side view of an embodiment of a prosthesis.
  • FIG. 3B is a flat pattern view of the prosthesis of FIG. 3A.
  • FIG. 4 is a side view of an embodiment of a prosthesis.
  • FIG. 5 is a side view of an embodiment of a prosthesis.
  • FIG. 6A is a side view of an embodiment of a prosthesis configured as a replacement heart valve.
  • FIG. 6B is a bottom view of the prosthesis similar of FIG. 6A.
  • FIG. 7 is a side view of an embodiment of a prosthesis configured as a replacement heart valve.
  • FIG. 8A is a side view of an embodiment of a prosthesis.
  • FIG. 8B is a detail view of a portion of the prosthesis of FIG. 8A.
  • FIG. 9A is a side view of an embodiment of a prosthesis.
  • FIG. 9B is a bottom view of the prosthesis of FIG. 9A, configured as a replacement heart valve.
  • FIG. 10 is a schematic representation of a prosthesis positioned within the heart.
  • FIG. 10A is a detail schematic representation of the prosthesis positioned within the heart of FIG. 10.
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • The present specification and drawings provide aspects and features of the disclosure in the context of several embodiments of prostheses, replacement heart valves, delivery devices and methods that are configured for use in the vasculature of a patient, such as for replacement of natural heart valves in a patient. These embodiments may be discussed in connection with replacing specific valves such as the patient's aortic or mitral valve. However, it is to be understood that the features and concepts discussed herein can be applied to products other than heart valve implants. For example, the controlled positioning, deployment, and securing features described herein can be applied to medical implants, for example other types of expandable prostheses, for use elsewhere in the body, such as within a vein, or the like. In addition, particular features of a valve, delivery device, etc. should not be taken as limiting, and features of any one embodiment discussed herein can be combined with features of other embodiments as desired and when appropriate.
  • With initial reference to FIG. 1A, an embodiment of a prosthesis 10 is shown. The illustrated prosthesis 10 includes a frame 20 that may be self-expanding or balloon expandable. The prosthesis may further include a replacement valve that can be designed to replace a damaged or diseased native heart valve such as a mitral valve. The replacement valve is not shown in this embodiment as to more clearly illustrate features of the frame 20, though it will be understood that a replacement valve is not required as part of the prosthesis. In addition, it will be understood that only a front portion of the frame 20 is shown for further ease of illustration.
  • The frame 20 can be made of many different materials, but is preferably made from metal. In some embodiments, the frame 20 can be made from a shape memory material, such as nitinol. A wire frame or a metal tube can be used to make the frame. The wire frame of a metal tube can be cut or etched to remove all but the desired metal skeleton. In some embodiments a metal tube is laser cut in a repeating pattern to form the frame. FIG. 1B illustrates the flat cut pattern of the frame shown in FIG. 1A. The flat pattern can be cut from a metal tube and then the tube can be bent and expanded to the shape shown in FIG. 1A. The frame 20 can further be expanded and/or compressed and/or otherwise worked to have the desired shape or shapes, such as for introduction and implantation.
  • As shown, the frame when in an expanded configuration, such as in a fully expanded configuration, has a bulbous or slightly bulbous shape, with a middle portion being larger than the proximal 32 and distal 34 ends. In some embodiments, the inside diameter of the both ends can be the same, or it can be bigger on one end than the other, while still having a middle portion larger than both the proximal and distal ends. In some embodiments, the effective diameter of the distal frame end is smaller than the effective diameter of the middle portion. The bulbous shape of the frame can advantageously allow the frame to engage a native valve annulus or other body cavity, while spacing the inlet and outlet from the heart or vessel wall. This can help reduce undesired contact between the prosthesis and the heart or vessel, such as the ventricular wall of the heart. In other embodiments, the frame may not have a bulbous portion, and can have substantially the same outer dimension along its entire length, or it may have one end larger than the other end. The prosthesis 10 and frame 20 may be similar to the replacement heart valves and associated frames disclosed in U.S. Pat. No. 8,403,983 and U.S. Publication Nos. 2010/0298931, 2011/0313515 and 2012/0078353 the entireties of each of which are hereby incorporated by reference and made a part of this specification. This is inclusive of the entire disclosure and is not in any way limited to the disclosure of the replacement heart valves and associated frames.
  • A number of struts collectively make up the frame 20. FIG. 1 illustrates the frame in an expanded configuration with a number of longitudinal struts 12 and undulating struts 14, with cells defined by the open spaces between the struts. The longitudinal struts may be arranged so that they are parallel or generally or substantially parallel to a longitudinal axis of the frame. The longitudinal axis of the frame may be defined as the central axis that extends through the center of the frame between the proximal 32 and distal 34 ends. Any number of configurations of struts can be used, such as the rings of undulating struts shown forming chevrons and diamonds, but also ovals, curves, and various other shapes. The illustrated embodiment includes two rings, or rows of chevrons shown in portion 16 and two rows of diamond-shaped cells shown in portion 18.
  • The frame 20 has a non-foreshortening portion 16 and a foreshortening portion 18. These portions can be defined by the frame 20 and the positioning of various types of struts along the frame 20. In FIG. 1 it can be seen that the longitudinal struts 12 span the length of the non-foreshortening portion 16, while undulating struts 14 form the foreshortening portion 18. When the frame is radially collapsed or compacted, the struts 14 become more parallel with respect to the longitudinal axis of the frame, causing an outer diameter of the frame to decrease and the longitudinal length of the frame to increase in the foreshortening portion 18. As the frame moves from a compacted position to an expanded position, the longitudinal length of the frame can decrease in the foreshortening portion 18. But, the frame length does not substantially change length in the non-foreshortening portion 16.
  • Foreshortening of the frame 20 can be used to engage and secure the prosthesis to intralumenal tissue in a body cavity, for example tissue at or adjacent a native valve, such as a native valve annulus and/or leaflets. Opposing anchors 22, 24 can be constructed on the frame 20 so that portions of the anchors, such as tips or ends 26, 28, move closer together as the frame foreshortens. As one example, this can allow the anchors 22, 24 to grasp tissue on opposite sides of the native mitral annulus to thereby secure the prosthesis at the mitral valve.
  • The anchors 22, 24 and anchor tips 26, 28 can be located anywhere along the frame 20 just so long as at least one of the anchors is either connected to the foreshortening portion 18 or the foreshortening portion is positioned between the anchors so that a portion of the anchors will be move closer together with expansion of the frame. As shown, the anchors 24 are connected to the foreshortening portion 18. The foreshortening portion can also be positioned anywhere along the frame, though it is shown towards the distal end 34. In some embodiments, both of the anchor tips 26, 28 are located in the foreshortening portion 18. In some embodiments, the foreshortening portion 18 may extend the entire length of the frame, such that there is no non-foreshortening portion 16.
  • Preferably, each of the anchors 22, 24 is positioned or extends generally radially outwardly from the frame 20 so that the anchor tips 26, 28 are generally spaced away or radially outward from the rest of the frame 20. For example, the anchor tips may be located radially outward from the middle portion of the frame, with the tips 26 and 28 being axially spaced from one another. In some embodiments, all or part of the structure connected to the anchor tip and extending radially from the frame, including one or more rings and/or struts, can be considered part of the anchor. The anchors can include a base located on the anchor on a side opposite the tip. The base can be for example where the anchor begins to extend from or away from the frame 20.
  • For example, proximal anchors 22 are shown having first 36 and second 38 struts forming a chevron and connected to longitudinal struts 12 at a base of the anchor. The first and second struts of the anchor 22 are bent at the base so that the anchor 22 extends radially outwardly from the frame as it extends generally distally towards the tip 26. The first and second struts can be connected to each other at a radially outward location to form an outwardly extending loop, and in some embodiments, the first and second struts can be joined at a third strut 40 that continues to extend outwardly and/or generally distally. Here the third strut 40 is a short strut. The anchor also includes an eyelet 46. As illustrated, the eyelet is located at the distal end 26, though the eyelet can be positioned in other locations along the anchor 22. The tips 26 of the proximal anchors may extend distally and be parallel or substantially parallel with the longitudinal axis of the frame, or as illustrated in FIG. 1A, the tips 26 may extend generally distally but still radially outwardly inclined or at an acute angle relative to the longitudinal axis of the frame.
  • As another example, the distal anchors 24 are shown having looped ends 48. The looped ends can be larger near the tip to form a type of elongated teardrop. In addition, the tips 28 may be substantially flat. The looped end may assist the frame in not getting caught up on structures at or near the treatment location. For example, each loop can be configured so that when the frame is deployed in-situ and expands, the movement of each loop from a delivered position to a deployed position can avoids getting caught on the papillary muscles.
  • Each distal anchor 24 is connected to the frame at a base 42. As illustrated in FIG. 1A, the base of the distal anchor may be at a location where the corners of adjacent cells meet, such that the base is proximal to the distal end 34 of the frame. In other embodiments, the base of the distal anchor may be at a distal most corner of a cell, which corresponds to a distal most point on the frame The distal anchors as illustrated extend from the base 42 generally distally before bending back around in an arcuate segment where the distal anchor extends generally proximally and radially outwardly from the frame. As shown, the anchors 24 may also generally distally and radially inwardly with respect to the frame such that the distal most point on the prosthesis has a smaller inside diameter than where the base 42 connects to the frame. The inside diameter at the distal most can be the same or substantially the same as the inside diameter of the proximal end, or may be smaller. The anchor as illustrated is bent around about 180 degrees so that the tip 28 extends in the opposite, proximal direction, which may be parallel or substantially parallel to the longitudinal axis of the frame. For example, in FIG. 1A it can be seen that the distal anchors 24 are bent further inward such that the ends of the anchors point proximally and are generally parallel with the longitudinal axis of the frame. Alternatively, the tip 28 may extend generally proximally but still extend radially outwardly inclined or at an acute angle relative to the longitudinal axis of the frame
  • It will be understood that the anchors can have various other configurations, including the various embodiments that follow. In some embodiments, each of the anchors can extend radially outwardly from the frame at an anchor base and terminate at an anchor tip. The anchors can be connected to the frame at one of many different locations including apices, junctions, other parts of struts, etc. The anchors can comprise first, second, third, or more spaced apart bending stages along the length of each anchor. The anchors can also extend either distally or proximally before and/or after one or more of the bending stages. A portion of the anchor may extend with the frame before or after any bending stages.
  • In the illustrated embodiment of FIG. 1A-B there are twelve distal anchors and twelve proximal anchors. In some embodiments there may be 6 anchors on one side and 12 on the other. Some embodiments may include different numbers of anchors. In addition, the distal and proximal anchors may be aligned so the tips point generally towards each other, or they may be spaced so that the tips point between two tips on the opposite side, as is illustrated in FIGS. 1A-B.
  • The anchor tips 26 and 28 as described above advantageously provide atraumatic surfaces that may be used to grasp intralumenal tissue without causing unnecessary or undesired trauma to tissue. For example, the proximal anchors tips 26 and distal anchor tips 28 may form flat, substantially flat, curved or other non-sharp surfaces to allow the tips to engage and/or grasp tissue, without necessarily piercing or puncturing through tissue.
  • FIGS. 2A-3B show prostheses similar to that of FIGS. 1A-B with two different styles of distal anchors 24. In FIGS. 2A-B, the looped end 48′ of the distal anchor is generally more elliptical with a curved tip as compared to the elongated teardrop shape of looped end 48 of FIGS. 1A-B. Otherwise the shape is substantially the same.
  • In FIGS. 3A-B, the distal anchors 24 are looped anchors rather than having looped ends. The looped anchor has a first base 42 and a second base 44 connected to the frame, wherein the first and second bases are at opposite corners of the same cell. Alternatively, the first and second bases may be located at the distal most corners of adjacent cells. The distal anchors 24 extends generally distally from the frame at the first base 42 but then is bent back around and begins to extend outwardly from the frame in a generally proximal direction. The distal anchor 24 then repeats this configuration in reverse towards the second base 44 such that the two sides of the looped anchor are mirror images of one another. It will be understood that the looped anchor can have other configurations and that it may not be symmetrical.
  • As illustrated in FIG. 3A, the tips 28 of the distal anchors are circumferentially aligned with the tips 26 of the proximal anchors, though in other embodiments, the tips 28 of the distal anchors may be circumferentially staggered between the tips 26 of the proximal anchors. In the embodiment of FIG. 3A, adjacent distal anchors 26 are spaced apart by one cell, though in other embodiments, adjacent distal anchors may be provided on adjacent cells. Thus, for example, instead of having six distal anchors and twelve proximal anchors as shown in FIG. 3A, there may be a 1:1 correspondence between proximal and distal anchors.
  • The illustrated looped distal anchor of FIGS. 3A-B is made up of the following segments. The first segment 50 extends generally longitudinally with the frame, extending distally or generally distally (e.g., slightly radially inward) with the frame. The strut is then bent so that a second segment 52 extends generally parallel with an adjacent undulating strut 14. The strut is then bent so that a third segment 54 begins to extend generally longitudinally and distally or generally distally, and then is bent back around to point in generally the opposite direction (e.g., in a proximal direction parallel or generally parallel with the longitudinal axis of the frame). The third segment 54 ends in the rounded tip 28 and then the anchor strut repeats to form the mirror image. After the third segment 54 bends back around to point in generally the opposite direction, in the embodiment illustrated the third segment may first extend radially outward at an acute angle relative to the longitudinal axis before bending into a portion that extends parallel or substantially parallel to the longitudinal axis. The paired third segments 54 extend parallel or generally parallel with one another from the second segment to the tip, though they may also move slightly towards or away from each other in some embodiments.
  • FIG. 4 shows a prosthesis similar to FIGS. 3A-B that also has looped distal anchors. In this embodiment the first segment 50 extends longitudinally in a distal direction from the frame and the strut is bent back on itself to point generally in the opposite (e.g., proximal) direction. The second segment is bent inward before extending parallel or generally parallel with its mirror image on the other side forming a nose and wing configuration similar to the shape of certain bicycle seats.
  • The proximal anchors 22 also have an elongated third strut 40. The proximal anchor 22 is shown having first 36 and second 38 struts forming a chevron and connected to longitudinal struts 12 at a base of the anchor. The first and second struts of the anchor 22 are bent at the base so that the anchor 22 extends radially outwardly from the frame as it extends towards the tip 26. The first and second struts join at a third strut 40 that continues to extend outwardly and is then bent such that the tip points distally and extends in a manner parallel or generally parallel with the longitudinal axis of the frame. The proximal anchor may or may not include an eyelet 46 along its length. The distal tip of the proximal anchors may have an atraumatic surface, such as an enlarged circular or curved end as illustrated. When the frame is in an expanded configuration, the distal anchors 24 may have tips 28 that are positioned radially outward of the tips 26 of the proximal anchors 22. Other embodiments may have the tips 26 being positioned outward of the tips 28. Such configurations are also possible with the other frames and prostheses described elsewhere herein.
  • FIG. 5 illustrated an embodiment similar to the prosthesis of FIG. 4 with twelve distal anchors instead of six. Because of this change, in one embodiment two anchors share the first segment 50 where the anchor base 42, 44 is connected to the frame. As illustrated, each of the proximal and distal anchors may be circumferentially aligned with each other, and each of the distal anchors corresponds to one of the cells
  • Turning now to FIGS. 6A-B, prosthesis and frame embodiments are shown similar to that of FIG. 4, including various other components of the prosthesis. A prosthesis can include one or more of a valve 60, a skirt 70 and a support band 80. The prosthesis can be a replacement heart valve similar to that and including features similar to those disclosed in U.S. patent application Ser. Nos. 13/165,721, filed Jun. 21, 2011, published as U.S. 2011/0313515; and 13/244,080, filed Sep. 23, 2011, published as 2012/0078353. The entire contents of both applications are hereby incorporated by reference herein and made a part of this specification. This is inclusive of the entire disclosure and is not in any way limited to the disclosure of the replacement heart valve.
  • The valve 60 can be a replacement heart valve which includes a plurality of valve leaflets 62. The plurality of valve leaflets 62 can function in a manner similar to the natural mitral valve, or to other valves in the vascular system. The plurality of valve leaflets 62 can open in a first position and then engage one another to close the valve in a second position. The plurality of valve leaflets 62 can be made to function as a one way valve such that flow in one direction opens the valve and flow in a second direction opposite the first direction closes the valve. The replacement heart valve 60 can be constructed so as to open naturally with the beating of the heart. For example, the plurality of valve leaflets 62 can open during diastole and close during systole.
  • In some embodiments, the leaflets 62 can be coupled to a skirt 70. For example, the proximal ends of the leaflets 62 can be connected to a proximal end of the skirt 70.
  • The skirt 70 can be used to at least partially control how fluid flows through and/or around the valve 60. The skirt 70 can surround at least a portion of the valve and be connected to the valve leaflets 62. In some embodiments, the skirt 70 can form an inner wall connected to and positioned within the frame 20. The skirt 70 can also be made to move with the foreshortening portion 18 of the frame 20.
  • The skirt 70 can extend the length of the frame 20 or it can extend along only part of the length of the frame 20. In some embodiments, the ends of the heart valve 60 can coincide with ends of the skirt 70. In addition, one or more of the ends of the frame 20 can coincide with the ends of the skirt 70. In the illustrated embodiment of FIGS. 6A-B, the proximal end of the skirt 70 and heart valve 60 are sewn together. The skirt 70 can not only extend to the distal end of the frame 20 but can also extend to the outside of the frame and is shown wrapped around each of the distal anchors 24.
  • Other shapes and configurations can also be used for the valve 60 and skirt 70. In some embodiments, the skirt 70 may extend along the length of the leaflets 62, but is not connected to them. In the illustrated embodiments, the skirt 70 is attached to the frame 20 and the leaflets 62 are attached to the skirt 70.
  • The skirt 70 can be constructed in multiple different ways. The skirt 70 can be made of knit polyester or another stretchable or flexible fabric. In some embodiments, the skirt 70 is made from a material that is more flexible than the valve leaflet material. The distal and/or proximal end of the skirt 70 can be straight, curved, or have any other desired configuration. For example, the skirt 70 is shown with undulations patterned to generally correspond to the undulations at the distal end 34 of the frame 20. It can be seen that the skirt 70 wraps around the struts at the distal end. The skirt 70 can be formed of one piece or multiple pieces. For example, the skirt 70 attached to the valve 60 can be one piece and then each distal anchor can be covered by a separate piece of material of the skirt 70. It is to be understood that other configurations of the skirt 70 can also be employed. For example, the anchors may remain uncovered, or only a portion may be covered.
  • Turning now to FIG. 7, another embodiment of the skirt 70 is shown. Here rather than the skirt 70 corresponding to the undulations at the distal end 34 of the frame 20, the skirt extends past the frame and is then wrapped around it. Thus, the skirt 70 extends from the inside of the frame 20 to the outside of the frame. The skirt can extend completely around the frame for ¼, ⅓, ½, or more of the length of the distal anchors. The skirt can also cover the distal anchors 24. In the illustrated embodiment, the skirt is a one piece skirt, but it will be understood that the skirt can be made of multiple pieces.
  • The skirt 70, and particularly portions that cover the distal anchors 24, can beneficially be used to help prevent leakage of blood flow around the heart valve. In addition, the skirt can encourage tissue in-growth between the skirt and the natural tissue. This may further help to prevent leakage of blood flow around the heart valve.
  • The prosthesis 10 can also include a support band 80 as is shown in FIGS. 6A-7. The support band 80 may be placed or positioned around or within the frame 20 at the proximal end 32. The support band 80 can be used to reinforce and/or constrain the frame 20. The support band 80 can help to control the expansion of the frame 20 from the compacted to the expanded state. The support band 80 can also be used to reduce the amount of motion that occurs at the proximal end 32 after the prosthesis 10 has been implanted at the mitral heart valve or other location.
  • In some embodiments, the support band 80 may comprise a polyester fabric band. The support band 80 may comprise a no-stretch or limited stretch material. Preferably the support band 80 is not made of an elastic material or a material known to have high elasticity. In some embodiments, the support band 80 is made from a material that is less flexible than the valve skirt material and/or the valve leaflet material. The distal and proximal ends of the support band 80 can be straight, curved, undulating with the undulations of frame, or any other desired configuration.
  • The support band 80 can be connected to the valve frame with a plurality of stitches, loops, knots, staples, or other types of connections. In some embodiments, the frame 20 can be sandwiched between two sides or layers of the support band 80. Preferably, the support band 80 is a single layer positioned within and attached to the frame 20 with a plurality of stitches around one or more of the longitudinal and/or undulating struts. In some embodiments, the support band 80 can be attached to the proximal end of the valve skirt 40.
  • Looking now at FIGS. 8A-B another embodiment of a prosthesis 10 is shown. FIGS. 8A-B show a prosthesis similar to that of FIG. 4 with a different style and configuration of distal anchor 24. In FIGS. 8A-B, the distal anchors are shorter than and spaced radially inward from the distal anchors of FIG. 4. Thus, as illustrated, the distal anchors 24 are not positioned as far radially outward as the proximal anchors, and the tips 28 may be positioned radially inward of the tips 26. As described further below, such a configuration may be advantageous in positioning and securing the prosthesis in a mitral valve or other body location. As shown particularly in FIG. 8B, the distal anchors 24 may comprise loops as described above, having a curved or arcuate atraumatic tip to minimize damage to body tissue.
  • FIGS. 9A-B show an embodiment of a prosthesis where the distal anchors do not comprise loops, but instead comprise single struts each extending distally from the corners where adjacent cells meet. As described with respect to embodiments above, these anchors may first extend distally or generally distally, and may further extend radially inward, before bending around to extend proximally or generally proximally, such as at an acute angle relative to the longitudinal axis of the frame. The tips 28 of the anchors may comprise an atraumatic surface, such as a flattened or curved enlarged tip. As illustrated, the tips 28 may be circumferentially staggered between tips 26 of the proximal anchors 22, as best shown in FIG. 9B. FIG. 9B also shows the frame 20 having a valve 60 and skirt 70 attached as described above.
  • In preferred embodiments, any of the prostheses 10 described above may be deployed into a heart valve annulus, and positioned when compacted so that the anchor tips 26, 28 of the opposing anchors 22, 24 are disposed on opposite sides of the native annulus 88 as shown in FIGS. 10 and 10A. As the replacement heart valve 10 is expanded, the opposing anchors are drawn closer together so as to grasp tissue on opposite sides of the native annulus 88 and securely hold the replacement heart valve 10 in position. As such, the replacement heart valve 10 can be held securely in position without requiring a substantial radial force against the native annulus. Because the anchor tips are preferably atraumatic, the grasping or engaging of tissue by the prosthesis minimizes damage to the native tissue. The foreshortening portion 18 can be used to move the anchor tips 26, 28 closer together as the replacement heart valve 10 moves to the expanded position to thereby engage the native valve annulus. The prosthesis can be deployed into a heart valve or otherwise deployed in manners similar to those described with respect to a replacement heart valve in U.S. Publication No. 2010/0298931 and 2012/0078353 the entireties of each of which are hereby incorporated by reference and made a part of this specification. This is inclusive of the entire disclosure and is not in any way limited to the disclosure related to deployment of a replacement heart valve.
  • FIGS. 10 and 10A show a schematic representation of the replacement heart valve 10 installed in a human heart 84. The heart is shown in cross-section, and represents typical anatomy, including a left atrium 78 and left ventricle 86. The left atrium 78 and left ventricle 86 communicate with one another through a mitral annulus 88. Also shown schematically is a native anterior mitral leaflet 90 having chordae tendineae 92 that connect a downstream end of the anterior mitral leaflet 90 and to the left ventricle 86.
  • In one preferred embodiment, a method is provided of delivering a replacement valve to a native mitral valve and atraumatically securing the replacement valve relative to the native mitral valve annulus 88. The replacement valve can be mounted on a delivery device and delivered to the native mitral valve annulus while the replacement valve is in a radially compacted state. The replacement valve may be positioned so that the ends or tips of the distal anchors are on a ventricular side of the native leaflets 90 beyond a location where chordae tendineae 92 connect to free ends of the native leaflets. At least a portion of the replacement valve can be released from the delivery device to thereby expand the distal anchors radially outwardly. At this time the distal anchors may extend between at least some of the chordae. The distal anchors (along with the frame) can be moved toward the ventricular side of the native valve annulus with the distal anchors extending between at least some of the chordae tendineae to provide tension on the chordae tendineae. With tension provided on the chordae tendineae, the replacement valve can be further released from the delivery device to thereby expand the proximal anchors radially outwardly. The proximal anchors upon further release of the replacement valve from the delivery device can move into engagement with tissue on an atrial side of the native valve annulus, such as with the atrial side of the native valve annulus.
  • The method just described may utilize any of the prostheses herein described, but may be particularly suitable for the prosthesis of FIGS. 8A-8B where the ends of the distal anchors are not positioned as far out radially as the ends of the proximal anchors when the frame is expanded. Thus, the distal anchors may have a suitable length for extending between and providing tension on the chordae tendineae, but need not and may not in some embodiments engage tissue with the tips 28. Thus, in some embodiments the some or all of the distal anchors remain spaced from tissue on the ventricular side of the native valve annulus after delivery and expansion. The interaction between the distal anchors and the chordae tendineae may therefore be sufficient to secure the distal end of the prosthesis, while the engagement of the proximal anchors with tissue on the atrial side of the native valve annulus will help further secure and orient the prosthesis
  • As illustrated in FIGS. 10 and 10A, the distal anchors may comprise loops, such as any of the looped structures previously described. The distal anchors may also be covered with a resilient material such as described above for the skirt 70 that promotes tissue growth with adjacent body tissue. Such material may also be useful to prevent paravalvular leakage. The atraumatic distal anchors may advantageously prevent snagging of the prosthesis on internal structures, such as the papillary muscles.
  • Although this invention has been disclosed in the context of certain preferred embodiments and examples, it will be understood by those skilled in the art that the present invention extends beyond the specifically disclosed embodiments to other alternative embodiments and/or uses of the invention and obvious modifications and equivalents thereof. In addition, while a number of variations of the invention have been shown and described in detail, other modifications, which are within the scope of this invention, will be readily apparent to those of skill in the art based upon this disclosure. It is also contemplated that various combinations or sub-combinations of the specific features and aspects of the embodiments may be made and still fall within the scope of the invention. Accordingly, it should be understood that various features and aspects of the disclosed embodiments can be combined with or substituted for one another in order to form varying modes of the disclosed invention. Thus, it is intended that the scope of the present invention herein disclosed should not be limited by the particular disclosed embodiments described above, but should be determined only by a fair reading of the claims that follow.
  • Similarly, this method of disclosure, is not to be interpreted as reflecting an intention that any claim require more features than are expressly recited in that claim. Rather, as the following claims reflect, inventive aspects lie in a combination of fewer than all features of any single foregoing disclosed embodiment. Thus, the claims following the Detailed Description are hereby expressly incorporated into this Detailed Description, with each claim standing on its own as a separate embodiment.

Claims (21)

1-31. (canceled)
32. A prosthesis configured to atraumatically engage intralumenal tissue when deployed within a body cavity, the prosthesis comprising:
an expandable frame comprising a proximal end and a distal end and having a longitudinal axis extending between the proximal end and the distal end, the frame configured to radially expand and contract for deployment within the body cavity; and
a plurality of distal anchors each connected to the frame at a base and having a looped atraumatic end;
wherein when the frame is in an expanded configuration:
each of the plurality of distal anchors extends from the base generally distally before extending generally proximally and radially outwardly from the frame; and
the looped atraumatic end of each distal anchor is circumferentially aligned with the base where the distal anchor connects to the frame so that the looped atraumatic end and the base are both located within a common plane that is parallel to and intersects the longitudinal axis.
33. The prosthesis of claim 32, wherein the frame comprises a plurality of cells formed by interconnected struts.
34. The prosthesis of claim 33, wherein when the frame is in an expanded configuration, a width of each of the plurality of distal anchors as defined circumferentially around the longitudinal axis over the entire length of the distal anchor from the base to the looped atraumatic end is less than the width of one cell.
35. The prosthesis of claim 33, wherein the base of each of the plurality of distal anchors is at a location where corners of two adjacent cells meet.
36. The prosthesis of claim 33, wherein the base of each of the plurality of distal anchors is at a distalmost corner of a cell.
37. The prosthesis of claim 33, wherein adjacent looped ends of the plurality of distal anchors are spaced apart by at least one cell.
38. The prosthesis of claim 32, further comprising a plurality of proximal anchors each connected to the frame, wherein when the frame is in an expanded configuration an end of each of the plurality of proximal anchors is positioned radially outward from the frame and extends generally distally so that the ends of the plurality of distal anchors are axially spaced from the ends of the proximal anchors, and wherein the frame is configured such that radial expansion of the frame causes ends of the plurality of proximal anchors and the ends of the plurality of distal anchors to draw closer together.
39. The prosthesis of claim 38, wherein the ends of the plurality of distal anchors are positioned radially outward from the ends of the plurality proximal anchors when the frame is in an expanded configuration.
40. The prosthesis of claim 38, wherein the ends of the plurality of distal anchors are not circumferentially aligned with the ends of the plurality proximal anchors when the frame is in an expanded configuration.
41. The prosthesis of claim 38, wherein the plurality of proximal anchors each comprises a single arm that terminates in an atraumatic tip.
42. The prosthesis of claim 32, further comprising a valve body attached to the frame.
43. The prosthesis of claim 32, further comprising a layer of resilient material covering each of the looped ends to facilitate in-growth of adjacent tissue when the prosthesis is deployed within a body cavity.
44. The prosthesis of claim 32, wherein when the frame is in an expanded configuration, the frame has a larger cross-sectional dimension in a middle portion of the frame and a smaller cross-sectional dimension in a proximal portion and a distal portion of the frame, wherein the middle portion is between the proximal and distal portions.
45. The prosthesis of claim 44, wherein the plurality of distal anchors extend from the distal portion of the frame and are configured so that when the frame is in an expanded configuration, each distal anchor of the plurality of distal anchors has an end positioned radially outward from the middle portion of the frame.
46. The prosthesis of claim 44, wherein the proximal end and the distal end have substantially the same cross-sectional dimension.
47. A prosthesis configured to atraumatically engage intralumenal tissue when deployed within a body cavity, the prosthesis comprising:
an expandable frame comprising a proximal end and a distal end and having a longitudinal axis extending between the proximal end and the distal end, the frame configured to radially expand and contract for deployment within the body cavity; and
a plurality of distal anchors each connected to the frame at a base and having a looped atraumatic end, wherein each of the plurality of distal anchors is connected to the frame with a single strut;
wherein when the frame is in an expanded configuration each of the plurality of distal anchors extends from the base generally distally before extending generally proximally and radially outwardly from the frame.
48. The prosthesis of claim 47, wherein the frame comprises a plurality of foreshortening cells, and each of the plurality of distal anchors is connected to the frame with a single strut extending from one of the cells.
49. The prosthesis of claim 48, wherein the frame comprises a foreshortening portion and a non-foreshortening portion, wherein the foreshortening portion comprises the plurality of foreshortening cells and is distal to the non-foreshortening portion.
50. The prosthesis of claim 49, further comprising a plurality of proximal anchors extending radially outward from the non-foreshortening portion of the frame when the frame is in an expanded configuration.
51. The prosthesis of claim 47, wherein when the frame is in an expanded configuration, the frame has a larger cross-sectional dimension in a middle portion of the frame and a smaller cross-sectional dimension in a proximal portion and a distal portion of the frame, wherein the middle portion is between the proximal and distal portions.
US14/197,690 2013-03-14 2014-03-05 Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery Abandoned US20140277427A1 (en)

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US15/947,168 US10583000B2 (en) 2013-03-14 2018-04-06 Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US16/783,868 US11324591B2 (en) 2013-03-14 2020-02-06 Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US17/733,914 US20220249225A1 (en) 2013-03-14 2022-04-29 Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery

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US16/783,868 Active 2034-12-17 US11324591B2 (en) 2013-03-14 2020-02-06 Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
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Cited By (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130131793A1 (en) * 2008-09-29 2013-05-23 Cardiaq Valve Technologies, Inc. Replacement heart valve and method
US20140088696A1 (en) * 2011-01-11 2014-03-27 Hans Reiner Figulla Prosthetic valve for replacing an atrioventricular heart valve
US9072603B2 (en) * 2010-02-24 2015-07-07 Medtronic Ventor Technologies, Ltd. Mitral prosthesis and methods for implantation
WO2015127283A1 (en) 2014-02-21 2015-08-27 Cardiaq Valve Technologies, Inc. Delivery device for controlled deployement of a replacement valve
US20150257882A1 (en) * 2014-03-11 2015-09-17 Highlife Sas Transcatheter valve prosthesis
US9180005B1 (en) 2014-07-17 2015-11-10 Millipede, Inc. Adjustable endolumenal mitral valve ring
US9192471B2 (en) 2007-01-08 2015-11-24 Millipede, Inc. Device for translumenal reshaping of a mitral valve annulus
WO2015179423A1 (en) 2014-05-19 2015-11-26 Cardiaq Valve Technologies, Inc. Replacement mitral valve with annular flap
US9241790B2 (en) 2010-05-05 2016-01-26 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9333073B2 (en) 2009-04-15 2016-05-10 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery method
US9345573B2 (en) * 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9433514B2 (en) 2005-11-10 2016-09-06 Edwards Lifesciences Cardiaq Llc Method of securing a prosthesis
WO2016176610A1 (en) 2015-04-30 2016-11-03 Edwards Lifesciences Cardiaq Llc Replacement mitral valve, delivery system for replacement mitral valve and methods of use
US20160361160A1 (en) * 2014-02-18 2016-12-15 St. Jude Medical, Cardiology Division, Inc. Bowed runners and corresponding valve assemblies for paravalvular leak protection
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US9597183B2 (en) 2008-10-01 2017-03-21 Edwards Lifesciences Cardiaq Llc Delivery system for vascular implant
US20170086973A1 (en) * 2015-05-25 2017-03-30 Horizon Scientific Corp. Transcatheter Pulmonary Ball Valve Assembly
US20170095328A1 (en) * 2014-06-06 2017-04-06 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US9681952B2 (en) 2013-01-24 2017-06-20 Mitraltech Ltd. Anchoring of prosthetic valve supports
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US9693865B2 (en) 2013-01-09 2017-07-04 4 Tech Inc. Soft tissue depth-finding tool
US9724083B2 (en) 2013-07-26 2017-08-08 Edwards Lifesciences Cardiaq Llc Systems and methods for sealing openings in an anatomical wall
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9730790B2 (en) 2009-09-29 2017-08-15 Edwards Lifesciences Cardiaq Llc Replacement valve and method
US9763657B2 (en) 2010-07-21 2017-09-19 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9788941B2 (en) 2010-03-10 2017-10-17 Mitraltech Ltd. Axially-shortening prosthetic valve
US9795480B2 (en) 2010-08-24 2017-10-24 Millipede, Inc. Reconfiguring tissue features of a heart annulus
US9801720B2 (en) 2014-06-19 2017-10-31 4Tech Inc. Cardiac tissue cinching
US9848983B2 (en) 2015-02-13 2017-12-26 Millipede, Inc. Valve replacement using rotational anchors
WO2018017886A1 (en) 2016-07-21 2018-01-25 Edwards Lifesciences Corporation Replacement heart valve prosthesis
WO2018035375A1 (en) 2016-08-19 2018-02-22 Edwards Lifesciences Corporation Steerable delivery system for replacement mitral valve and methods of use
WO2018039631A1 (en) 2016-08-26 2018-03-01 Edwards Lifesciences Corporation Multi-portion replacement heat valve prosthesis
US9907681B2 (en) 2013-03-14 2018-03-06 4Tech Inc. Stent with tether interface
US9907547B2 (en) 2014-12-02 2018-03-06 4Tech Inc. Off-center tissue anchors
USD815744S1 (en) 2016-04-28 2018-04-17 Edwards Lifesciences Cardiaq Llc Valve frame for a delivery system
US20180125647A1 (en) * 2016-11-04 2018-05-10 Highlife Sas Transcatheter valve prosthesis
US20180133011A1 (en) * 2016-11-14 2018-05-17 Laboratoires Invalv Implant for treating a biological valve
US9974651B2 (en) 2015-02-05 2018-05-22 Mitral Tech Ltd. Prosthetic valve with axially-sliding frames
US9999502B2 (en) 2016-11-04 2018-06-19 Highlife Sas Transcather valve prosthesis
US10022114B2 (en) 2013-10-30 2018-07-17 4Tech Inc. Percutaneous tether locking
JP2018519138A (en) * 2015-05-25 2018-07-19 ヴィーナス メドテック (ハンゾウ)インコーポレーテッドVenus Medtech (Hangzhou), Inc. Transcatheter pulmonary valve assembly
US10045845B2 (en) 2012-11-13 2018-08-14 Mitraltech Ltd. Percutaneously-deliverable mechanical valve
US10052095B2 (en) 2013-10-30 2018-08-21 4Tech Inc. Multiple anchoring-point tension system
US10058323B2 (en) 2010-01-22 2018-08-28 4 Tech Inc. Tricuspid valve repair using tension
US10092400B2 (en) 2015-06-23 2018-10-09 Edwards Lifesciences Cardiaq Llc Systems and methods for anchoring and sealing a prosthetic heart valve
US10117744B2 (en) 2015-08-26 2018-11-06 Edwards Lifesciences Cardiaq Llc Replacement heart valves and methods of delivery
US10195027B2 (en) 2016-11-04 2019-02-05 Highlife Sas Transcatheter valve prosthesis
US20190053894A1 (en) * 2017-08-17 2019-02-21 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
USD841813S1 (en) 2017-08-03 2019-02-26 Cardiovalve Ltd. Prosthetic heart valve element
US10226335B2 (en) 2015-06-22 2019-03-12 Edwards Lifesciences Cardiaq Llc Actively controllable heart valve implant and method of controlling same
US10226341B2 (en) 2011-08-05 2019-03-12 Cardiovalve Ltd. Implant for heart valve
US10231831B2 (en) 2009-12-08 2019-03-19 Cardiovalve Ltd. Folding ring implant for heart valve
US20190083249A1 (en) * 2017-09-19 2019-03-21 Cardiovalve Ltd. Prosthetic valve with inflatable cuff configured to fill a volume between atrial and ventricular tissue anchors
US10238491B2 (en) 2010-01-22 2019-03-26 4Tech Inc. Tricuspid valve repair using tension
US10245143B2 (en) 2011-08-05 2019-04-02 Cardiovalve Ltd. Techniques for percutaneous mitral valve replacement and sealing
US10335275B2 (en) 2015-09-29 2019-07-02 Millipede, Inc. Methods for delivery of heart valve devices using intravascular ultrasound imaging
US10350065B2 (en) 2006-07-28 2019-07-16 Edwards Lifesciences Cardiaq Llc Percutaneous valve prosthesis and system and method for implanting the same
US10350066B2 (en) 2015-08-28 2019-07-16 Edwards Lifesciences Cardiaq Llc Steerable delivery system for replacement mitral valve and methods of use
WO2019144121A1 (en) 2018-01-22 2019-07-25 Edwards Lifesciences Corporation Heart shape preserving anchor
WO2019147846A2 (en) 2018-01-25 2019-08-01 Edwards Lifesciences Corporation Delivery system for aided replacement valve recapture and repositioning post- deployment
US10376361B2 (en) 2011-08-05 2019-08-13 Cardiovalve Ltd. Techniques for percutaneous mitral valve replacement and sealing
US10390952B2 (en) 2015-02-05 2019-08-27 Cardiovalve Ltd. Prosthetic valve with flexible tissue anchor portions
WO2019169087A1 (en) 2018-02-28 2019-09-06 Edwards Lifesciences Corporation Prosthetic mitral valve with improved anchors and seal
US10405978B2 (en) 2010-01-22 2019-09-10 4Tech Inc. Tricuspid valve repair using tension
US10441416B2 (en) 2015-04-21 2019-10-15 Edwards Lifesciences Corporation Percutaneous mitral valve replacement device
US10456247B2 (en) 2016-11-04 2019-10-29 Highlife Sas Transcatheter valve prosthesis
US10463483B2 (en) * 2014-12-19 2019-11-05 Venus Medtech (Hangzhou) Inc. Minimally invasive mitral valve replacement with brim
US10485660B2 (en) 2010-06-21 2019-11-26 Edwards Lifesciences Cardiaq Llc Replacement heart valve
US10492908B2 (en) 2014-07-30 2019-12-03 Cardiovalve Ltd. Anchoring of a prosthetic valve
US10543088B2 (en) 2012-09-14 2020-01-28 Boston Scientific Scimed, Inc. Mitral valve inversion prostheses
US10548731B2 (en) 2017-02-10 2020-02-04 Boston Scientific Scimed, Inc. Implantable device and delivery system for reshaping a heart valve annulus
US10555813B2 (en) 2015-11-17 2020-02-11 Boston Scientific Scimed, Inc. Implantable device and delivery system for reshaping a heart valve annulus
US10575951B2 (en) 2015-08-26 2020-03-03 Edwards Lifesciences Cardiaq Llc Delivery device and methods of use for transapical delivery of replacement mitral valve
US10575948B2 (en) 2017-08-03 2020-03-03 Cardiovalve Ltd. Prosthetic heart valve
US10583000B2 (en) 2013-03-14 2020-03-10 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US10583002B2 (en) 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
US10736739B2 (en) 2016-11-04 2020-08-11 Highlife Sas Transcatheter valve prosthesis
US10743992B2 (en) * 2015-03-24 2020-08-18 St. Jude Medical, Cardiology Division, Inc. Prosthetic mitral valve
US10758348B2 (en) 2016-11-02 2020-09-01 Edwards Lifesciences Corporation Supra and sub-annular mitral valve delivery system
WO2020198389A1 (en) * 2019-03-25 2020-10-01 Inqb8 Medical Technologies Llc Prosthetic heart valve
US10813757B2 (en) 2017-07-06 2020-10-27 Edwards Lifesciences Corporation Steerable rail delivery system
US10849755B2 (en) 2012-09-14 2020-12-01 Boston Scientific Scimed, Inc. Mitral valve inversion prostheses
US10856975B2 (en) 2016-08-10 2020-12-08 Cardiovalve Ltd. Prosthetic valve with concentric frames
US10888421B2 (en) 2017-09-19 2021-01-12 Cardiovalve Ltd. Prosthetic heart valve with pouch
US10905550B2 (en) 2017-02-01 2021-02-02 Medtronic Vascular, Inc. Heart valve prostheses including torque anchoring mechanisms and delivery devices for the heart valve prostheses
WO2021025979A1 (en) 2019-08-02 2021-02-11 Edwards Lifesciences Corporation Rotary application of fibrous material to medical devices
WO2021080782A1 (en) 2019-10-23 2021-04-29 Edwards Lifesciences Corporation Systems and methods for tricuspid valve treatment
US11000373B2 (en) * 2017-04-18 2021-05-11 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11013598B2 (en) 2018-01-09 2021-05-25 Edwards Lifesciences Corporation Native valve repair devices and procedures
US11058539B2 (en) 2017-04-18 2021-07-13 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
WO2021154493A1 (en) 2020-01-28 2021-08-05 Edwards Lifesciences Corporation Apparatus and methods for loading and deploying implants from delivery apparatuses
US11083582B2 (en) 2018-10-10 2021-08-10 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11110251B2 (en) 2017-09-19 2021-09-07 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
WO2021188405A1 (en) 2020-03-18 2021-09-23 Edwards Lifesciences Corporation Textiles, implantable medical devices using such textiles, and processes for making the same
WO2021194899A1 (en) 2020-03-24 2021-09-30 Edwards Lifesciences Corporation Delivery system configurations
WO2021221748A1 (en) 2020-04-28 2021-11-04 Edwards Lifesciences Corporation Silk-based electrospun materials for implant systems and devices
US11166778B2 (en) 2017-04-28 2021-11-09 Edwards Lifesciences Corporation Medical device stabilizing apparatus and method of use
CN113768660A (en) * 2020-06-10 2021-12-10 先健科技(深圳)有限公司 Prosthetic heart valve and prosthetic heart valve system
US11207181B2 (en) 2018-04-18 2021-12-28 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11219746B2 (en) 2016-03-21 2022-01-11 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
US11224509B2 (en) * 2017-06-30 2022-01-18 Ohio State Innovation Foundation Prosthetic heart valve with tri-leaflet design for use in percutaneous valve replacement procedures
US11246704B2 (en) 2017-08-03 2022-02-15 Cardiovalve Ltd. Prosthetic heart valve
US11259927B2 (en) 2018-01-09 2022-03-01 Edwards Lifesciences Corporation Native valve repair devices and procedures
US20220087814A1 (en) * 2020-09-24 2022-03-24 Cephea Valve Technologies, Inc. Controlled Expression of Expandable Heart Valve
US11291547B2 (en) 2011-08-05 2022-04-05 Cardiovalve Ltd. Leaflet clip with collars
US11298228B2 (en) 2018-01-09 2022-04-12 Edwards Lifesciences Corporation Native valve repair devices and procedures
US11382746B2 (en) 2017-12-13 2022-07-12 Cardiovalve Ltd. Prosthetic valve and delivery tool therefor
US20220218468A1 (en) * 2017-05-31 2022-07-14 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
US11389297B2 (en) 2018-04-12 2022-07-19 Edwards Lifesciences Corporation Mitral valve spacer device
WO2022155336A1 (en) 2021-01-14 2022-07-21 Edwards Lifesciences Corporation Implantable medical devices
WO2022174047A1 (en) 2021-02-11 2022-08-18 Edwards Lifesciences Corporation Dual-frame replacement heart valves
WO2022216793A1 (en) 2021-04-07 2022-10-13 Edwards Lifesciences Corporation Implantable medical devices
WO2022226090A1 (en) 2021-04-21 2022-10-27 Edwards Lifesciences Corporation Textiles for implantation
WO2022242093A1 (en) * 2021-05-17 2022-11-24 金仕生物科技(常熟)有限公司 Tricuspid valve frame and valve prosthesis thereof
US11517718B2 (en) 2016-11-07 2022-12-06 Edwards Lifesciences Corporation Apparatus for the introduction and manipulation of multiple telescoping catheters
US11547564B2 (en) 2018-01-09 2023-01-10 Edwards Lifesciences Corporation Native valve repair devices and procedures
US11612485B2 (en) 2018-01-09 2023-03-28 Edwards Lifesciences Corporation Native valve repair devices and procedures
US11633277B2 (en) 2018-01-10 2023-04-25 Cardiovalve Ltd. Temperature-control during crimping of an implant
US11653910B2 (en) 2010-07-21 2023-05-23 Cardiovalve Ltd. Helical anchor implantation
WO2023091769A1 (en) 2021-11-22 2023-05-25 Edwards Lifesciences Corporation Systems and methods for implant deployment
WO2023091520A1 (en) 2021-11-19 2023-05-25 Edwards Lifesciences Corporation Heart valve repair devices
US11660185B2 (en) 2009-12-04 2023-05-30 Edwards Lifesciences Corporation Ventricular anchors for valve repair and replacement devices
CN116250971A (en) * 2023-05-09 2023-06-13 杭州启明医疗器械股份有限公司 Expandable sheath for transcatheter delivery system and delivery system
US11690621B2 (en) 2014-12-04 2023-07-04 Edwards Lifesciences Corporation Percutaneous clip for repairing a heart valve
WO2023154250A1 (en) 2022-02-09 2023-08-17 Edwards Lifesciences Corporation Systems and methods for force reduction in delivery systems
US11730598B2 (en) 2017-09-07 2023-08-22 Edwards Lifesciences Corporation Prosthetic device for heart valve
US11779742B2 (en) 2019-05-20 2023-10-10 Neovasc Tiara Inc. Introducer with hemostasis mechanism
WO2023200706A1 (en) 2022-04-15 2023-10-19 Edwards Lifesciences Corporation Methods and apparatus for removal of valve repair devices
US11793642B2 (en) 2015-05-14 2023-10-24 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11793633B2 (en) 2017-08-03 2023-10-24 Cardiovalve Ltd. Prosthetic heart valve
US11839544B2 (en) 2019-02-14 2023-12-12 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11918469B2 (en) 2021-02-05 2024-03-05 Edwards Lifesciences Corporation Native valve repair devices and procedures

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10456243B2 (en) * 2015-10-09 2019-10-29 Medtronic Vascular, Inc. Heart valves prostheses and methods for percutaneous heart valve replacement
JP7006940B2 (en) 2016-01-29 2022-01-24 ニオバスク ティアラ インコーポレイテッド Artificial valve to avoid blockage of outflow
WO2018090148A1 (en) 2016-11-21 2018-05-24 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
EP3672530A4 (en) 2017-08-25 2021-04-14 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
CN210301306U (en) * 2018-01-07 2020-04-14 苏州杰成医疗科技有限公司 Heart valve prosthesis delivery system
EP3796876B1 (en) 2018-05-22 2022-07-27 Boston Scientific Scimed, Inc. Percutaneous papillary muscle relocation
JP7260930B2 (en) 2018-11-08 2023-04-19 ニオバスク ティアラ インコーポレイテッド Ventricular deployment of a transcatheter mitral valve prosthesis
EP3946163A4 (en) 2019-04-01 2022-12-21 Neovasc Tiara Inc. Controllably deployable prosthetic valve
WO2020210652A1 (en) 2019-04-10 2020-10-15 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
WO2020257643A1 (en) 2019-06-20 2020-12-24 Neovasc Tiara Inc. Low profile prosthetic mitral valve
US11109965B2 (en) 2020-02-06 2021-09-07 Laplace Interventional Inc. Transcatheter heart valve prosthesis assembled inside heart chambers or blood vessels
US11510777B1 (en) 2022-02-10 2022-11-29 Laplace Interventional Inc. Prosthetic heart valves
US11638643B1 (en) 2022-07-20 2023-05-02 Laplace Interventional Inc. Prosthetic heart valves

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090287299A1 (en) * 2008-01-24 2009-11-19 Charles Tabor Stents for prosthetic heart valves
US20100249923A1 (en) * 2007-09-28 2010-09-30 St Jude Medical Inc. Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features
US20110313515A1 (en) * 2010-06-21 2011-12-22 Arshad Quadri Replacement heart valve
US20120022640A1 (en) * 2010-07-21 2012-01-26 Yossi Gross Techniques for percutaneous mitral valve replacement and sealing
US20120215303A1 (en) * 2009-09-29 2012-08-23 Cardiaq Valve Technologies, Inc. Replacement heart valve and method
WO2012177942A2 (en) * 2011-06-21 2012-12-27 Hanson Gifford, Iii Prosthetic heart valve devices and associated systems and methods

Family Cites Families (438)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1264471A (en) 1968-01-12 1972-02-23
US3671979A (en) 1969-09-23 1972-06-27 Univ Utah Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve
US3657744A (en) 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
GB1315844A (en) 1970-05-12 1973-05-02 Nat Res Dev Prosthetic cardiac valve
US3739402A (en) 1970-10-15 1973-06-19 Cutter Lab Bicuspid fascia lata valve
AR206762A1 (en) 1976-01-01 1976-08-13 Pisanu A LOW PROFILE BIOPROTHESIS DERIVED FROM PORCINE HETEROLOGICAL AORTIC VALVE
US4056854A (en) 1976-09-28 1977-11-08 The United States Of America As Represented By The Department Of Health, Education And Welfare Aortic heart valve catheter
GB1603634A (en) 1977-05-05 1981-11-25 Nat Res Dev Prosthetic valves
US4265694A (en) 1978-12-14 1981-05-05 The United States Of America As Represented By The Department Of Health, Education And Welfare Method of making unitized three leaflet heart valve
US4222126A (en) 1978-12-14 1980-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health, Education & Welfare Unitized three leaflet heart valve
US4340977A (en) 1980-09-19 1982-07-27 Brownlee Richard T Catenary mitral valve replacement
US4339831A (en) 1981-03-27 1982-07-20 Medtronic, Inc. Dynamic annulus heart valve and reconstruction ring
US4470157A (en) 1981-04-27 1984-09-11 Love Jack W Tricuspid prosthetic tissue heart valve
US4865600A (en) 1981-08-25 1989-09-12 Baxter International Inc. Mitral valve holder
US4553545A (en) 1981-09-16 1985-11-19 Medinvent S.A. Device for application in blood vessels or other difficultly accessible locations and its use
ATE21330T1 (en) 1982-01-20 1986-08-15 Martin Morris Black ARTIFICIAL HEART VALVES.
US4477930A (en) 1982-09-28 1984-10-23 Mitral Medical International, Inc. Natural tissue heat valve and method of making same
US4777951A (en) 1986-09-19 1988-10-18 Mansfield Scientific, Inc. Procedure and catheter instrument for treating patients for aortic stenosis
US4994077A (en) 1989-04-21 1991-02-19 Dobben Richard L Artificial heart valve for implantation in a blood vessel
US5411552A (en) 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis
DK124690D0 (en) 1990-05-18 1990-05-18 Henning Rud Andersen FAT PROTECTION FOR IMPLEMENTATION IN THE BODY FOR REPLACEMENT OF NATURAL FLEET AND CATS FOR USE IN IMPLEMENTING A SUCH FAT PROTECTION
GB9012716D0 (en) 1990-06-07 1990-08-01 Frater Robert W M Mitral heart valve replacements
US5163955A (en) 1991-01-24 1992-11-17 Autogenics Rapid assembly, concentric mating stent, tissue heart valve with enhanced clamping and tissue alignment
US5370685A (en) 1991-07-16 1994-12-06 Stanford Surgical Technologies, Inc. Endovascular aortic valve replacement
US5795325A (en) 1991-07-16 1998-08-18 Heartport, Inc. Methods and apparatus for anchoring an occluding member
US5332402A (en) 1992-05-12 1994-07-26 Teitelbaum George P Percutaneously-inserted cardiac valve
US5522885A (en) 1994-05-05 1996-06-04 Autogenics Assembly tooling for an autologous tissue heart valve
US5554185A (en) 1994-07-18 1996-09-10 Block; Peter C. Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same
US6428489B1 (en) 1995-12-07 2002-08-06 Precision Vascular Systems, Inc. Guidewire system
EP1477133B9 (en) 1996-03-05 2007-11-21 Evysio Medical Devices Ulc Expandable stent
US5855601A (en) 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
DE19624948A1 (en) 1996-06-24 1998-01-02 Adiam Medizintechnik Gmbh & Co Prosthetic heart valve
DE19625202A1 (en) 1996-06-24 1998-01-02 Adiam Medizintechnik Gmbh & Co Prosthetic mitral heart valve
EP0850607A1 (en) 1996-12-31 1998-07-01 Cordis Corporation Valve prosthesis for implantation in body channels
US5957949A (en) 1997-05-01 1999-09-28 World Medical Manufacturing Corp. Percutaneous placement valve stent
US6746422B1 (en) 2000-08-23 2004-06-08 Norborn Medical, Inc. Steerable support system with external ribs/slots that taper
US20040254635A1 (en) 1998-03-30 2004-12-16 Shanley John F. Expandable medical device for delivery of beneficial agent
US6322585B1 (en) 1998-11-16 2001-11-27 Endotex Interventional Systems, Inc. Coiled-sheet stent-graft with slidable exo-skeleton
US6733523B2 (en) 1998-12-11 2004-05-11 Endologix, Inc. Implantable vascular graft
US6896690B1 (en) 2000-01-27 2005-05-24 Viacor, Inc. Cardiac valve procedure methods and devices
US6325825B1 (en) 1999-04-08 2001-12-04 Cordis Corporation Stent with variable wall thickness
JP4657456B2 (en) 1999-04-09 2011-03-23 イバルブ・インコーポレーテッド Method and apparatus for heart valve repair
AU4242800A (en) 1999-04-23 2000-11-10 St. Jude Medical Cardiovascular Group, Inc. Artificial heart valve attachment apparatus
US6712836B1 (en) 1999-05-13 2004-03-30 St. Jude Medical Atg, Inc. Apparatus and methods for closing septal defects and occluding blood flow
US6790229B1 (en) 1999-05-25 2004-09-14 Eric Berreklouw Fixing device, in particular for fixing to vascular wall tissue
US6312465B1 (en) 1999-07-23 2001-11-06 Sulzer Carbomedics Inc. Heart valve prosthesis with a resiliently deformable retaining member
US6440164B1 (en) 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
US6749560B1 (en) 1999-10-26 2004-06-15 Circon Corporation Endoscope shaft with slotted tube
US8579966B2 (en) 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US20070043435A1 (en) 1999-11-17 2007-02-22 Jacques Seguin Non-cylindrical prosthetic valve system for transluminal delivery
US7018406B2 (en) 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
US8016877B2 (en) 1999-11-17 2011-09-13 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US6458153B1 (en) 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
ES2286097T7 (en) 2000-01-31 2009-11-05 Cook Biotech, Inc ENDOPROTESIS VALVES.
DE10010074B4 (en) 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device for fastening and anchoring heart valve prostheses
DE60108847T2 (en) 2000-03-03 2006-03-23 Cook Inc., Bloomington TUBULAR FLAP AND STENT FOR THE TREATMENT OF VASCULAR FLUID
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
US6729356B1 (en) 2000-04-27 2004-05-04 Endovascular Technologies, Inc. Endovascular graft for providing a seal with vasculature
US6610088B1 (en) 2000-05-03 2003-08-26 Shlomo Gabbay Biologically covered heart valve prosthesis
US6358277B1 (en) 2000-06-21 2002-03-19 The International Heart Institute Of Montana Foundation Atrio-ventricular valvular device
US6527800B1 (en) 2000-06-26 2003-03-04 Rex Medical, L.P. Vascular device and method for valve leaflet apposition
US6695878B2 (en) 2000-06-26 2004-02-24 Rex Medical, L.P. Vascular device for valve leaflet apposition
US6676698B2 (en) 2000-06-26 2004-01-13 Rex Medicol, L.P. Vascular device with valve for approximating vessel wall
US7510572B2 (en) 2000-09-12 2009-03-31 Shlomo Gabbay Implantation system for delivery of a heart valve prosthesis
DE10046550A1 (en) 2000-09-19 2002-03-28 Adiam Life Science Ag Prosthetic mitral heart valve consists of support housing with base ring and two stanchions
US6893459B1 (en) 2000-09-20 2005-05-17 Ample Medical, Inc. Heart valve annulus device and method of using same
EP1208816B1 (en) 2000-10-13 2005-12-14 Medtronic AVE Inc. Hydraulic stent delivery system
US6482228B1 (en) 2000-11-14 2002-11-19 Troy R. Norred Percutaneous aortic valve replacement
US6974476B2 (en) 2003-05-05 2005-12-13 Rex Medical, L.P. Percutaneous aortic valve
US6733525B2 (en) 2001-03-23 2004-05-11 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of use
DE10121210B4 (en) 2001-04-30 2005-11-17 Universitätsklinikum Freiburg Anchoring element for the intraluminal anchoring of a heart valve replacement and method for its production
US6716207B2 (en) 2001-05-22 2004-04-06 Scimed Life Systems, Inc. Torqueable and deflectable medical device shaft
US7547322B2 (en) 2001-07-19 2009-06-16 The Cleveland Clinic Foundation Prosthetic valve and method for making same
FR2828091B1 (en) 2001-07-31 2003-11-21 Seguin Jacques ASSEMBLY ALLOWING THE PLACEMENT OF A PROTHETIC VALVE IN A BODY DUCT
FR2828263B1 (en) 2001-08-03 2007-05-11 Philipp Bonhoeffer DEVICE FOR IMPLANTATION OF AN IMPLANT AND METHOD FOR IMPLANTATION OF THE DEVICE
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
GB0125925D0 (en) 2001-10-29 2001-12-19 Univ Glasgow Mitral valve prosthesis
US20030176914A1 (en) 2003-01-21 2003-09-18 Rabkin Dmitry J. Multi-segment modular stent and methods for manufacturing stents
US20030105517A1 (en) 2001-12-05 2003-06-05 White Geoffrey Hamilton Non-foreshortening stent
US7014653B2 (en) 2001-12-20 2006-03-21 Cleveland Clinic Foundation Furcated endovascular prosthesis
US7201771B2 (en) 2001-12-27 2007-04-10 Arbor Surgical Technologies, Inc. Bioprosthetic heart valve
US20030130729A1 (en) 2002-01-04 2003-07-10 David Paniagua Percutaneously implantable replacement heart valve device and method of making same
US20030199971A1 (en) 2002-04-23 2003-10-23 Numed, Inc. Biological replacement valve assembly
WO2003092554A1 (en) 2002-05-03 2003-11-13 The General Hospital Corporation Involuted endovascular valve and method of construction
US20030220683A1 (en) 2002-05-22 2003-11-27 Zarouhi Minasian Endoluminal device having barb assembly and method of using same
US7264632B2 (en) 2002-06-07 2007-09-04 Medtronic Vascular, Inc. Controlled deployment delivery system
US8518096B2 (en) 2002-09-03 2013-08-27 Lifeshield Sciences Llc Elephant trunk thoracic endograft and delivery system
US6875231B2 (en) 2002-09-11 2005-04-05 3F Therapeutics, Inc. Percutaneously deliverable heart valve
CO5500017A1 (en) 2002-09-23 2005-03-31 3F Therapeutics Inc MITRAL PROTESTIC VALVE
DE60325634D1 (en) 2002-10-01 2009-02-12 Ample Medical Inc DEVICES AND SYSTEMS FOR FORMING A HEADLAP ANNULUS
US7485143B2 (en) 2002-11-15 2009-02-03 Abbott Cardiovascular Systems Inc. Apparatuses and methods for heart valve repair
GB2398245B (en) 2003-02-06 2007-03-28 Great Ormond Street Hospital F Valve prosthesis
US7025779B2 (en) * 2003-02-26 2006-04-11 Scimed Life Systems, Inc. Endoluminal device having enhanced affixation characteristics
JP4624984B2 (en) 2003-03-12 2011-02-02 クック インコーポレイテッド Artificial valve that allows backflow
WO2004082528A2 (en) 2003-03-17 2004-09-30 Cook Incorporated Vascular valve with removable support component
US7175656B2 (en) 2003-04-18 2007-02-13 Alexander Khairkhahan Percutaneous transcatheter heart valve replacement
EP1472996B1 (en) 2003-04-30 2009-09-30 Medtronic Vascular, Inc. Percutaneously delivered temporary valve
EP1648339B2 (en) 2003-07-08 2020-06-17 Ventor Technologies Ltd. Implantable prosthetic devices particularly for transarterial delivery in the treatment of aortic stenosis, and methods of implanting such devices
US7201772B2 (en) 2003-07-08 2007-04-10 Ventor Technologies, Ltd. Fluid flow prosthetic device
US7621948B2 (en) 2003-07-21 2009-11-24 The Trustees Of The University Of Pennsylvania Percutaneous heart valve
EP1659992B1 (en) 2003-07-31 2013-03-27 Cook Medical Technologies LLC Prosthetic valve devices and methods of making such devices
US20050075725A1 (en) 2003-10-02 2005-04-07 Rowe Stanton J. Implantable prosthetic valve with non-laminar flow
US7101396B2 (en) 2003-10-06 2006-09-05 3F Therapeutics, Inc. Minimally invasive valve replacement system
US7553324B2 (en) 2003-10-14 2009-06-30 Xtent, Inc. Fixed stent delivery devices and methods
US7192440B2 (en) 2003-10-15 2007-03-20 Xtent, Inc. Implantable stent delivery devices and methods
US7635382B2 (en) 2003-10-22 2009-12-22 Medtronic Vascular, Inc. Delivery system for long self-expanding stents
US7740656B2 (en) 2003-11-17 2010-06-22 Medtronic, Inc. Implantable heart valve prosthetic devices having intrinsically conductive polymers
US7186265B2 (en) 2003-12-10 2007-03-06 Medtronic, Inc. Prosthetic cardiac valves and systems and methods for implanting thereof
US7261732B2 (en) 2003-12-22 2007-08-28 Henri Justino Stent mounted valve
US20120041550A1 (en) 2003-12-23 2012-02-16 Sadra Medical, Inc. Methods and Apparatus for Endovascular Heart Valve Replacement Comprising Tissue Grasping Elements
US7780725B2 (en) 2004-06-16 2010-08-24 Sadra Medical, Inc. Everting heart valve
US20050137694A1 (en) 2003-12-23 2005-06-23 Haug Ulrich R. Methods and apparatus for endovascularly replacing a patient's heart valve
US20050137686A1 (en) 2003-12-23 2005-06-23 Sadra Medical, A Delaware Corporation Externally expandable heart valve anchor and method
US7824443B2 (en) 2003-12-23 2010-11-02 Sadra Medical, Inc. Medical implant delivery and deployment tool
EP2926767B2 (en) 2003-12-23 2023-03-08 Boston Scientific Scimed, Inc. Repositionable heart valve
US9005273B2 (en) 2003-12-23 2015-04-14 Sadra Medical, Inc. Assessing the location and performance of replacement heart valves
DE10394350B4 (en) 2003-12-23 2018-05-17 Cormove To be implanted in a lumen to be implanted parts set and prosthesis the same
EP3492042A1 (en) 2003-12-23 2019-06-05 Boston Scientific Scimed, Inc. Repositionable heart valve
US8287584B2 (en) 2005-11-14 2012-10-16 Sadra Medical, Inc. Medical implant deployment tool
US7381219B2 (en) 2003-12-23 2008-06-03 Sadra Medical, Inc. Low profile heart valve and delivery system
US20050137691A1 (en) 2003-12-23 2005-06-23 Sadra Medical Two piece heart valve and anchor
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US7329279B2 (en) 2003-12-23 2008-02-12 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US7445631B2 (en) 2003-12-23 2008-11-04 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
WO2005062980A2 (en) 2003-12-23 2005-07-14 Sadra Medical, Inc. Repositionable heart valve
US7748389B2 (en) 2003-12-23 2010-07-06 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US8182528B2 (en) 2003-12-23 2012-05-22 Sadra Medical, Inc. Locking heart valve anchor
US8343213B2 (en) 2003-12-23 2013-01-01 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US8828078B2 (en) 2003-12-23 2014-09-09 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US20050137687A1 (en) 2003-12-23 2005-06-23 Sadra Medical Heart valve anchor and method
US7871435B2 (en) 2004-01-23 2011-01-18 Edwards Lifesciences Corporation Anatomically approximate prosthetic mitral heart valve
CA2556077C (en) 2004-02-05 2012-05-01 Children's Medical Center Corporation Transcatheter delivery of a replacement heart valve
US7311730B2 (en) 2004-02-13 2007-12-25 Shlomo Gabbay Support apparatus and heart valve prosthesis for sutureless implantation
ITTO20040135A1 (en) 2004-03-03 2004-06-03 Sorin Biomedica Cardio Spa CARDIAC VALVE PROSTHESIS
EP2308425B2 (en) 2004-03-11 2023-10-18 Percutaneous Cardiovascular Solutions Pty Limited Percutaneous Heart Valve Prosthesis
EP2422751A3 (en) 2004-05-05 2013-01-02 Direct Flow Medical, Inc. Unstented heart valve with formed in place support structure
US20060095115A1 (en) 2004-05-10 2006-05-04 Youssef Bladillah Stent and method of manufacturing same
US7276078B2 (en) 2004-06-30 2007-10-02 Edwards Lifesciences Pvt Paravalvular leak detection, sealing, and prevention
US7462191B2 (en) 2004-06-30 2008-12-09 Edwards Lifesciences Pvt, Inc. Device and method for assisting in the implantation of a prosthetic valve
US20060052867A1 (en) 2004-09-07 2006-03-09 Medtronic, Inc Replacement prosthetic heart valve, system and method of implant
JP2008514345A (en) 2004-10-02 2008-05-08 クリストフ・ハンス・フーバー Device for treating or replacing a heart valve or surrounding tissue without requiring full cardiopulmonary support
US7402151B2 (en) 2004-12-17 2008-07-22 Biocardia, Inc. Steerable guide catheters and methods for their use
DE102005003632A1 (en) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Catheter for the transvascular implantation of heart valve prostheses
ITTO20050074A1 (en) 2005-02-10 2006-08-11 Sorin Biomedica Cardio Srl CARDIAC VALVE PROSTHESIS
DK1850796T3 (en) 2005-02-18 2016-01-18 Cleveland Clinic Foundation DEVICE FOR REPLACEMENT OF A HEART VALVE
US7722666B2 (en) 2005-04-15 2010-05-25 Boston Scientific Scimed, Inc. Valve apparatus, system and method
EP1893131A1 (en) 2005-04-20 2008-03-05 The Cleveland Clinic Foundation Apparatus and method for replacing a cardiac valve
SE531468C2 (en) 2005-04-21 2009-04-14 Edwards Lifesciences Ag An apparatus for controlling blood flow
US7914569B2 (en) 2005-05-13 2011-03-29 Medtronics Corevalve Llc Heart valve prosthesis and methods of manufacture and use
EP1883375B1 (en) 2005-05-24 2016-12-07 Edwards Lifesciences Corporation Rapid deployment prosthetic heart valve
US7780723B2 (en) 2005-06-13 2010-08-24 Edwards Lifesciences Corporation Heart valve delivery system
US8790396B2 (en) 2005-07-27 2014-07-29 Medtronic 3F Therapeutics, Inc. Methods and systems for cardiac valve delivery
US7455689B2 (en) 2005-08-25 2008-11-25 Edwards Lifesciences Corporation Four-leaflet stented mitral heart valve
WO2007025028A1 (en) 2005-08-25 2007-03-01 The Cleveland Clinic Foundation Percutaneous atrioventricular valve and method of use
US20070129794A1 (en) 2005-10-05 2007-06-07 Fidel Realyvasquez Method and apparatus for prosthesis attachment using discrete elements
US7563277B2 (en) 2005-10-24 2009-07-21 Cook Incorporated Removable covering for implantable frame projections
DE102005052628B4 (en) 2005-11-04 2014-06-05 Jenavalve Technology Inc. Self-expanding, flexible wire mesh with integrated valvular prosthesis for the transvascular heart valve replacement and a system with such a device and a delivery catheter
WO2007058857A2 (en) 2005-11-10 2007-05-24 Arshad Quadri Balloon-expandable, self-expanding, vascular prosthesis connecting stent
US8764820B2 (en) 2005-11-16 2014-07-01 Edwards Lifesciences Corporation Transapical heart valve delivery system and method
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US8777975B2 (en) 2005-12-30 2014-07-15 C.R. Bard, Inc. Embolus blood clot filter with bio-resorbable coated filter members
EP2583640B1 (en) 2006-02-16 2022-06-22 Venus MedTech (HangZhou), Inc. Minimally invasive replacement heart valve
US8591516B2 (en) 2006-02-27 2013-11-26 Biomet Manufacturing, Llc Patient-specific orthopedic instruments
US8219229B2 (en) 2006-03-02 2012-07-10 Edwards Lifesciences Corporation Virtual heart valve
WO2007123658A1 (en) 2006-03-28 2007-11-01 Medtronic, Inc. Prosthetic cardiac valve formed from pericardium material and methods of making same
US8652201B2 (en) 2006-04-26 2014-02-18 The Cleveland Clinic Foundation Apparatus and method for treating cardiovascular diseases
CN101442958B (en) 2006-04-28 2012-09-05 麦德托尼克公司 Apparatus for cardiac valve replacement
EP2012712B1 (en) 2006-04-29 2016-02-10 Medtronic, Inc. Guide shields for multiple component prosthetic heart valve assemblies
JP2009536074A (en) 2006-05-05 2009-10-08 チルドレンズ・メディカル・センター・コーポレイション Transcatheter heart valve
WO2007134358A1 (en) 2006-05-23 2007-11-29 Allvascular Pty Ltd Endovenous valve transfer stent
US20090188964A1 (en) 2006-06-01 2009-07-30 Boris Orlov Membrane augmentation, such as of for treatment of cardiac valves, and fastening devices for membrane augmentation
US20080021546A1 (en) 2006-07-18 2008-01-24 Tim Patz System for deploying balloon-expandable heart valves
US20090306768A1 (en) 2006-07-28 2009-12-10 Cardiaq Valve Technologies, Inc. Percutaneous valve prosthesis and system and method for implanting same
US8834564B2 (en) 2006-09-19 2014-09-16 Medtronic, Inc. Sinus-engaging valve fixation member
US8414643B2 (en) 2006-09-19 2013-04-09 Medtronic Ventor Technologies Ltd. Sinus-engaging valve fixation member
FR2906454B1 (en) 2006-09-28 2009-04-10 Perouse Soc Par Actions Simpli IMPLANT INTENDED TO BE PLACED IN A BLOOD CIRCULATION CONDUIT.
AU2007299934B2 (en) 2006-09-28 2013-09-12 Hlt, Inc. Delivery tool for percutaneous delivery of a prosthesis
US7534261B2 (en) 2006-10-02 2009-05-19 Edwards Lifesciences Corporation Sutureless heart valve attachment
US8784478B2 (en) 2006-10-16 2014-07-22 Medtronic Corevalve, Inc. Transapical delivery system with ventruculo-arterial overlfow bypass
DE102006052564B3 (en) 2006-11-06 2007-12-13 Georg Lutter Mitral valve stent for surgical implantation and fixation of heart valve prosthesis to heart, has stent clips arranged distally, where one of stent clips forms section that is externally rolled in unfolded condition of stent
EP2097012A4 (en) 2006-11-07 2012-08-15 David Stephen Celermajer Devices and methods for the treatment of heart failure
US8715270B2 (en) 2006-12-01 2014-05-06 Boston Scientific Scimed, Inc. Multi-part instrument systems and methods
JP5593545B2 (en) 2006-12-06 2014-09-24 メドトロニック シーブイ ルクセンブルク エス.アー.エール.エル. System and method for transapical delivery of a self-expanding valve secured to an annulus
FR2909857B1 (en) 2006-12-14 2009-03-06 Perouse Soc Par Actions Simpli Endovalve.
US8070799B2 (en) 2006-12-19 2011-12-06 Sorin Biomedica Cardio S.R.L. Instrument and method for in situ deployment of cardiac valve prostheses
EP2094194B1 (en) 2006-12-19 2015-09-02 St. Jude Medical, Inc. Prosthetic heart valve including stent structure and tissue leaflets, and related methods
DE602006013167D1 (en) 2006-12-19 2010-05-06 Sorin Biomedica Cardio Srl Instrument for in situ insertion of heart valve prostheses
US8236045B2 (en) 2006-12-22 2012-08-07 Edwards Lifesciences Corporation Implantable prosthetic valve assembly and method of making the same
US8105375B2 (en) 2007-01-19 2012-01-31 The Cleveland Clinic Foundation Method for implanting a cardiovascular valve
EP2111190B1 (en) 2007-01-19 2013-10-09 Medtronic, Inc. Stented heart valve devices for atrioventricular valve replacement
US7967853B2 (en) 2007-02-05 2011-06-28 Boston Scientific Scimed, Inc. Percutaneous valve, system and method
EP2124826B2 (en) 2007-02-15 2020-09-23 Medtronic, Inc. Multi-layered stents
EP2129332B1 (en) 2007-02-16 2019-01-23 Medtronic, Inc. Replacement prosthetic heart valves
US8070802B2 (en) 2007-02-23 2011-12-06 The Trustees Of The University Of Pennsylvania Mitral valve system
US20080208328A1 (en) 2007-02-23 2008-08-28 Endovalve, Inc. Systems and Methods For Placement of Valve Prosthesis System
JP5114548B2 (en) 2007-04-13 2013-01-09 イエナバルブ テクノロジー インク Medical device for treating heart valve dysfunction or stenosis
EP2150210B1 (en) 2007-05-15 2016-10-12 JenaValve Technology, Inc. Handle for manipulating a catheter tip, catheter system and medical insertion system for inserting a self-expandable heart valve stent
ES2788453T3 (en) 2007-06-04 2020-10-21 St Jude Medical Llc Prosthetic heart valves
BRPI0813773A2 (en) 2007-06-26 2017-05-16 St Jude Medical apparatus for providing a protein heart valve in a patient.
US8006535B2 (en) 2007-07-12 2011-08-30 Sorin Biomedica Cardio S.R.L. Expandable prosthetic valve crimping device
US8828079B2 (en) 2007-07-26 2014-09-09 Boston Scientific Scimed, Inc. Circulatory valve, system and method
US8747458B2 (en) 2007-08-20 2014-06-10 Medtronic Ventor Technologies Ltd. Stent loading tool and method for use thereof
EP3075355A1 (en) 2007-08-23 2016-10-05 Direct Flow Medical, Inc. Translumenally implantable heart valve with formed in place support
WO2009029199A1 (en) 2007-08-24 2009-03-05 St. Jude Medical, Inc. Prosthetic aortic heart valves
US8114154B2 (en) 2007-09-07 2012-02-14 Sorin Biomedica Cardio S.R.L. Fluid-filled delivery system for in situ deployment of cardiac valve prostheses
DE102007043830A1 (en) 2007-09-13 2009-04-02 Lozonschi, Lucian, Madison Heart valve stent
US8220121B2 (en) 2007-09-14 2012-07-17 Cook Medical Technologies Llc Device for loading a self-expandable prosthesis into a sheath
WO2009045331A1 (en) 2007-09-28 2009-04-09 St. Jude Medical, Inc. Two-stage collapsible/expandable prosthetic heart valves and anchoring systems
US20090138079A1 (en) 2007-10-10 2009-05-28 Vector Technologies Ltd. Prosthetic heart valve for transfemoral delivery
EP2211779B1 (en) 2007-10-15 2014-08-20 Edwards Lifesciences Corporation Transcatheter heart valve with micro-anchors
JP5603776B2 (en) 2007-10-25 2014-10-08 サイメティス エスアー Stent, valved stent and method, and delivery system thereof
WO2009061389A2 (en) 2007-11-05 2009-05-14 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with non-expanding stent posts and retrieval features
US20090171456A1 (en) 2007-12-28 2009-07-02 Kveen Graig L Percutaneous heart valve, system, and method
US8926688B2 (en) 2008-01-11 2015-01-06 W. L. Gore & Assoc. Inc. Stent having adjacent elements connected by flexible webs
WO2009091509A1 (en) 2008-01-16 2009-07-23 St. Jude Medical, Inc. Delivery and retrieval systems for collapsible/expandable prosthetic heart valves
WO2009094197A1 (en) 2008-01-24 2009-07-30 Medtronic, Inc. Stents for prosthetic heart valves
ATE518502T1 (en) 2008-01-24 2011-08-15 Medtronic Vascular Inc INFUNDIBULUM REDUCING DEVICE DEPLOYMENT SYSTEM AND RELATED METHODS
US8157853B2 (en) 2008-01-24 2012-04-17 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
AU2009219415B2 (en) * 2008-02-25 2013-01-17 Medtronic Vascular Inc. Infundibular reducer devices
US8465540B2 (en) 2008-02-26 2013-06-18 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis
WO2009108355A1 (en) 2008-02-28 2009-09-03 Medtronic, Inc. Prosthetic heart valve systems
EP2594230B1 (en) 2008-02-29 2021-04-28 Edwards Lifesciences Corporation Expandable member for deploying a prosthetic device
DE102008012113A1 (en) 2008-03-02 2009-09-03 Transcatheter Technologies Gmbh Implant e.g. heart-valve-carrying stent, for e.g. arresting blood vessel, has fiber by which section of implant is reducible according to increasing of implant at extended diameter by unfolding or expansion of diameter with expansion unit
US8313525B2 (en) 2008-03-18 2012-11-20 Medtronic Ventor Technologies, Ltd. Valve suturing and implantation procedures
US7815673B2 (en) 2008-04-01 2010-10-19 Medtronic Vascular, Inc. Double-walled stent system
CA2722366C (en) 2008-04-23 2016-08-30 Medtronic, Inc. Stented heart valve devices
EP3141219A1 (en) 2008-04-23 2017-03-15 Medtronic, Inc. Stented heart valve devices
US8312825B2 (en) 2008-04-23 2012-11-20 Medtronic, Inc. Methods and apparatuses for assembly of a pericardial prosthetic heart valve
US8136218B2 (en) 2008-04-29 2012-03-20 Medtronic, Inc. Prosthetic heart valve, prosthetic heart valve assembly and method for making same
US20090276027A1 (en) 2008-05-01 2009-11-05 Medtronic Vasscular, Inc. Stent Graft Delivery System and Method of Use
US20090276040A1 (en) 2008-05-01 2009-11-05 Edwards Lifesciences Corporation Device and method for replacing mitral valve
ATE554731T1 (en) 2008-05-16 2012-05-15 Sorin Biomedica Cardio Srl ATRAAUMATIC PROSTHETIC HEART VALVE PROSTHESIS
CA3201875A1 (en) 2008-06-06 2009-12-10 Edwards Lifesciences Corporation Low profile transcatheter heart valve
US20110160836A1 (en) 2008-06-20 2011-06-30 Vysera Biomedical Limited Valve device
US8323335B2 (en) 2008-06-20 2012-12-04 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves and methods for using
WO2010005524A2 (en) 2008-06-30 2010-01-14 Bolton Medical, Inc. Abdominal aortic aneurysms: systems and methods of use
ES2616743T3 (en) 2008-07-15 2017-06-14 St. Jude Medical, Llc Collapsible and re-expandable prosthetic heart valve sleeve designs and complementary technological applications
WO2010008549A1 (en) 2008-07-15 2010-01-21 St. Jude Medical, Inc. Axially anchoring collapsible and re-expandable prosthetic heart valves for various disease states
US8652202B2 (en) * 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
US8721714B2 (en) 2008-09-17 2014-05-13 Medtronic Corevalve Llc Delivery system for deployment of medical devices
CA2749026C (en) 2008-09-29 2018-01-09 Impala, Inc. Heart valve
EP2341871B1 (en) 2008-10-01 2017-03-22 Edwards Lifesciences CardiAQ LLC Delivery system for vascular implant
US8790387B2 (en) 2008-10-10 2014-07-29 Edwards Lifesciences Corporation Expandable sheath for introducing an endovascular delivery device into a body
ES2627860T3 (en) 2008-10-10 2017-07-31 Boston Scientific Scimed, Inc. Medical devices and placement systems for placing medical devices
US8690936B2 (en) 2008-10-10 2014-04-08 Edwards Lifesciences Corporation Expandable sheath for introducing an endovascular delivery device into a body
US8137398B2 (en) 2008-10-13 2012-03-20 Medtronic Ventor Technologies Ltd Prosthetic valve having tapered tip when compressed for delivery
US20100114305A1 (en) * 2008-10-30 2010-05-06 Wei-Chang Kang Implantable Valvular Prosthesis
EP2358297B1 (en) 2008-11-21 2019-09-11 Percutaneous Cardiovascular Solutions Pty Limited Heart valve prosthesis
EP2201911B1 (en) 2008-12-23 2015-09-30 Sorin Group Italia S.r.l. Expandable prosthetic valve having anchoring appendages
US8500733B2 (en) 2009-02-20 2013-08-06 Boston Scientific Scimed, Inc. Asymmetric dual directional steerable catheter sheath
US20100217382A1 (en) 2009-02-25 2010-08-26 Edwards Lifesciences Mitral valve replacement with atrial anchoring
EP2408399B1 (en) 2009-03-17 2023-11-01 Mitrassist Medical Ltd. Heart valve prosthesis with collapsible valve
US8366767B2 (en) 2009-03-30 2013-02-05 Causper Medical Inc. Methods and devices for transapical delivery of a sutureless valve prosthesis
US9980818B2 (en) 2009-03-31 2018-05-29 Edwards Lifesciences Corporation Prosthetic heart valve system with positioning markers
US20100256723A1 (en) 2009-04-03 2010-10-07 Medtronic Vascular, Inc. Prosthetic Valve With Device for Restricting Expansion
JP2012523894A (en) 2009-04-15 2012-10-11 カルディアック バルブ テクノロジーズ,インコーポレーテッド Vascular implant and its placement system
US9011524B2 (en) 2009-04-24 2015-04-21 Medtronic, Inc. Prosthetic heart valves and methods of attaching same
US8353953B2 (en) 2009-05-13 2013-01-15 Sorin Biomedica Cardio, S.R.L. Device for the in situ delivery of heart valves
US8075611B2 (en) 2009-06-02 2011-12-13 Medtronic, Inc. Stented prosthetic heart valves
EP2448522A4 (en) 2009-07-02 2018-01-31 The Cleveland Clinic Foundation Apparatus and method for replacing a diseased cardiac valve
CN102573703B (en) 2009-08-27 2014-12-10 麦德托尼克公司 Transcatheter valve delivery systems and methods
EP2470122B1 (en) 2009-08-28 2019-10-09 Medtronic 3F Therapeutics, Inc. Crimping device and method of use
US9757107B2 (en) 2009-09-04 2017-09-12 Corvia Medical, Inc. Methods and devices for intra-atrial shunts having adjustable sizes
US8562673B2 (en) 2009-09-21 2013-10-22 Medtronic, Inc. Stented transcatheter prosthetic heart valve delivery system and method
AU2010311811B2 (en) 2009-11-02 2015-09-17 Symetis Sa Aortic bioprosthesis and systems for delivery thereof
CA2779393C (en) 2009-11-05 2020-06-09 The Trustees Of The University Of Pennsylvania Valve prosthesis
US8449599B2 (en) 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US8870950B2 (en) 2009-12-08 2014-10-28 Mitral Tech Ltd. Rotation-based anchoring of an implant
EP2512375B1 (en) 2009-12-15 2016-12-07 Edwards Lifesciences Corporation Expansion device for treatment of vascular passageways
US8518106B2 (en) 2010-02-17 2013-08-27 Medtronic, Inc. Catheter assembly with valve crimping accessories
US8475523B2 (en) 2010-02-17 2013-07-02 Medtronic, Inc. Distal tip assembly for a heart valve delivery catheter
US8926693B2 (en) 2010-02-17 2015-01-06 Medtronic, Inc. Heart valve delivery catheter with safety button
US10433956B2 (en) 2010-02-24 2019-10-08 Medtronic Ventor Technologies Ltd. Mitral prosthesis and methods for implantation
US8795354B2 (en) 2010-03-05 2014-08-05 Edwards Lifesciences Corporation Low-profile heart valve and delivery system
US8679404B2 (en) 2010-03-05 2014-03-25 Edwards Lifesciences Corporation Dry prosthetic heart valve packaging system
US20110224785A1 (en) 2010-03-10 2011-09-15 Hacohen Gil Prosthetic mitral valve with tissue anchors
US8551021B2 (en) 2010-03-31 2013-10-08 Boston Scientific Scimed, Inc. Guidewire with an improved flexural rigidity profile
US8491650B2 (en) 2010-04-08 2013-07-23 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system and method with stretchable stability tube
US8512400B2 (en) 2010-04-09 2013-08-20 Medtronic, Inc. Transcatheter heart valve delivery system with reduced area moment of inertia
US8998980B2 (en) 2010-04-09 2015-04-07 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with recapturing feature and method
US8512401B2 (en) 2010-04-12 2013-08-20 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with funnel recapturing feature and method
US8579963B2 (en) 2010-04-13 2013-11-12 Medtronic, Inc. Transcatheter prosthetic heart valve delivery device with stability tube and method
US8740976B2 (en) 2010-04-21 2014-06-03 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with flush report
US8623079B2 (en) 2010-04-23 2014-01-07 Medtronic, Inc. Stents for prosthetic heart valves
CN102917668B (en) 2010-04-27 2015-01-28 美敦力公司 Transcatheter prosthetic heart valve delivery device with biased release features
JP5688865B2 (en) 2010-04-27 2015-03-25 メドトロニック,インコーポレイテッド Transcatheter prosthetic heart valve delivery device with passive trigger release
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
US9387077B2 (en) 2010-05-27 2016-07-12 Medtronic Vascular Galway Catheter assembly with prosthesis crimping and prosthesis retaining accessories
US9132009B2 (en) * 2010-07-21 2015-09-15 Mitraltech Ltd. Guide wires with commissural anchors to advance a prosthetic valve
BR112013003601A2 (en) 2010-08-17 2016-08-16 St Jude Medical placement system for placing a flexible prosthetic heart valve, and method for producing a delivery system
US20120078360A1 (en) 2010-09-23 2012-03-29 Nasser Rafiee Prosthetic devices, systems and methods for replacing heart valves
EP2618784B1 (en) 2010-09-23 2016-05-25 Edwards Lifesciences CardiAQ LLC Replacement heart valves and delivery devices
US10321998B2 (en) 2010-09-23 2019-06-18 Transmural Systems Llc Methods and systems for delivering prostheses using rail techniques
US8845720B2 (en) 2010-09-27 2014-09-30 Edwards Lifesciences Corporation Prosthetic heart valve frame with flexible commissures
ES2875847T3 (en) 2010-10-05 2021-11-11 Edwards Lifesciences Corp Prosthetic heart valve with delivery catheter
EP2629699B1 (en) 2010-10-21 2017-01-04 Medtronic, Inc. Mitral bioprosthesis with low ventricular profile
US8562663B2 (en) 2010-10-26 2013-10-22 Medtronic Ventor Technologies Ltd. Devices and methods for loading a prosthesis onto a delivery system
US9072872B2 (en) 2010-10-29 2015-07-07 Medtronic, Inc. Telescoping catheter delivery system for left heart endocardial device placement
GB2485338B (en) 2010-11-02 2012-12-05 Cook Medical Technologies Llc Introducer assembly and dilator tip therefor
WO2012068175A2 (en) * 2010-11-16 2012-05-24 Trivascular, Inc. Advanced endovascular graft and delivery system
ES2710002T3 (en) * 2011-01-11 2019-04-22 Hans Reiner Figulla Valvular prosthesis to replace an atrioventricular valve of the heart
JP6002150B2 (en) 2011-01-11 2016-10-05 シメティス・ソシエテ・アノニムSymetis Sa Guide catheter and combination including the same
US20140025163A1 (en) 2011-01-25 2014-01-23 Emory University Systems, devices and methods for surgical and precutaneous replacement of a valve
EP2688516B1 (en) 2011-03-21 2022-08-17 Cephea Valve Technologies, Inc. Disk-based valve apparatus
US9055937B2 (en) 2011-04-01 2015-06-16 Edwards Lifesciences Corporation Apical puncture access and closure system
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US8945209B2 (en) 2011-05-20 2015-02-03 Edwards Lifesciences Corporation Encapsulated heart valve
US9289282B2 (en) 2011-05-31 2016-03-22 Edwards Lifesciences Corporation System and method for treating valve insufficiency or vessel dilatation
WO2012175483A1 (en) 2011-06-20 2012-12-27 Jacques Seguin Prosthetic leaflet assembly for repairing a defective cardiac valve and methods of using the same
EP2723272A4 (en) 2011-06-24 2015-01-28 Inceptus Medical LLC Percutaneously implantable artificial heart valve system and associated methods and devices
US8795357B2 (en) 2011-07-15 2014-08-05 Edwards Lifesciences Corporation Perivalvular sealing for transcatheter heart valve
CA2841952C (en) 2011-07-20 2018-07-03 Boston Scientific Scimed, Inc. Heart valve replacement
US20140324164A1 (en) 2011-08-05 2014-10-30 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US8852272B2 (en) 2011-08-05 2014-10-07 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
WO2013021374A2 (en) * 2011-08-05 2013-02-14 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9480559B2 (en) 2011-08-11 2016-11-01 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US20130331929A1 (en) 2011-09-09 2013-12-12 Endoluminal Sciences Pty Ltd. Means for Controlled Sealing of Endovascular Devices
US8956404B2 (en) * 2011-09-12 2015-02-17 Highlife Sas Transcatheter valve prosthesis
US9549817B2 (en) 2011-09-22 2017-01-24 Transmural Systems Llc Devices, systems and methods for repairing lumenal systems
WO2013131069A1 (en) 2012-03-02 2013-09-06 Mehr Medical Llc Prostheses
US9763780B2 (en) 2011-10-19 2017-09-19 Twelve, Inc. Devices, systems and methods for heart valve replacement
US9655722B2 (en) 2011-10-19 2017-05-23 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
EP4252714A3 (en) 2011-10-19 2023-12-20 Twelve, Inc. Device for heart valve replacement
CN103974674B (en) 2011-10-19 2016-11-09 托尔福公司 Artificial heart valve film device, artificial mitral valve and related system and method
US9039757B2 (en) 2011-10-19 2015-05-26 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
WO2013070896A1 (en) 2011-11-08 2013-05-16 Boston Scientific Scimed Inc. Replacement heart valve leaflet stitching method and device
FR2982763B1 (en) * 2011-11-17 2015-07-17 Ct Hospitalier Regional Universitaire D Amiens IMPLANT FOR PLACEMENT IN BLOOD CIRCULATION PASSAGE AND TREATMENT DEVICE THEREFOR
EP2785282A4 (en) * 2011-12-01 2016-01-13 Univ Pennsylvania Percutaneous valve replacement devices
US8652145B2 (en) 2011-12-14 2014-02-18 Edwards Lifesciences Corporation System and method for crimping a prosthetic valve
US9277993B2 (en) 2011-12-20 2016-03-08 Boston Scientific Scimed, Inc. Medical device delivery systems
US20140100651A1 (en) 2012-02-21 2014-04-10 California Institute Of Technology Medical Device Fastener Mechanisms
US20130274873A1 (en) 2012-03-22 2013-10-17 Symetis Sa Transcatheter Stent-Valves and Methods, Systems and Devices for Addressing Para-Valve Leakage
GB2500432A (en) 2012-03-22 2013-09-25 Stephen Brecker Replacement heart valve with resiliently deformable securing means
ES2535295T3 (en) 2012-03-23 2015-05-08 Sorin Group Italia S.R.L. Folding valve prosthesis
US8926694B2 (en) 2012-03-28 2015-01-06 Medtronic Vascular Galway Limited Dual valve prosthesis for transcatheter valve implantation
US9445897B2 (en) 2012-05-01 2016-09-20 Direct Flow Medical, Inc. Prosthetic implant delivery device with introducer catheter
US9277990B2 (en) 2012-05-04 2016-03-08 St. Jude Medical, Cardiology Division, Inc. Hypotube shaft with articulation mechanism
ES2807506T3 (en) 2012-05-20 2021-02-23 Tel Hashomer Medical Res Infrastructure & Services Ltd Prosthetic mitral valve
US9883941B2 (en) 2012-06-19 2018-02-06 Boston Scientific Scimed, Inc. Replacement heart valve
US10376360B2 (en) 2012-07-27 2019-08-13 W. L. Gore & Associates, Inc. Multi-frame prosthetic valve apparatus and methods
WO2014022124A1 (en) 2012-07-28 2014-02-06 Tendyne Holdings, Inc. Improved multi-component designs for heart valve retrieval device, sealing structures and stent assembly
EP2695586B1 (en) 2012-08-10 2019-05-08 Sorin Group Italia S.r.l. A valve prosthesis and kit
US10206775B2 (en) * 2012-08-13 2019-02-19 Medtronic, Inc. Heart valve prosthesis
US9232995B2 (en) 2013-01-08 2016-01-12 Medtronic, Inc. Valve prosthesis and method for delivery
CN105078615B (en) 2012-09-21 2018-10-09 上海微创心通医疗科技有限公司 Interior tube assembly for implant delivery system
US8628571B1 (en) 2012-11-13 2014-01-14 Mitraltech Ltd. Percutaneously-deliverable mechanical valve
US10321986B2 (en) 2012-12-19 2019-06-18 W. L. Gore & Associates, Inc. Multi-frame prosthetic heart valve
US10039638B2 (en) 2012-12-19 2018-08-07 W. L. Gore & Associates, Inc. Geometric prosthetic heart valves
EP2938291B2 (en) 2012-12-27 2023-01-11 Venus MedTech (HangZhou), Inc. Apparatus and set for folding or unfolding a medical implant comprising a clamping mechanism
US8986371B2 (en) * 2013-01-08 2015-03-24 Medtronic CV Luxembourg S.a.r.l. Method of treating paravalvular leakage after prosthetic valve implantation
US9066801B2 (en) 2013-01-08 2015-06-30 Medtronic, Inc. Valve prosthesis and method for delivery
US9132007B2 (en) 2013-01-10 2015-09-15 Medtronic CV Luxembourg S.a.r.l. Anti-paravalvular leakage components for a transcatheter valve prosthesis
WO2014115149A2 (en) 2013-01-24 2014-07-31 Mitraltech Ltd. Ventricularly-anchored prosthetic valves
US10413401B2 (en) 2013-02-01 2019-09-17 Medtronic CV Luxembourg S.a.r.l. Anti-paravalvular leakage component for a transcatheter valve prosthesis
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US9844435B2 (en) 2013-03-01 2017-12-19 St. Jude Medical, Cardiology Division, Inc. Transapical mitral valve replacement
US9119713B2 (en) 2013-03-11 2015-09-01 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve replacement
US10583002B2 (en) 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
EP2967849A4 (en) 2013-03-12 2017-01-18 St. Jude Medical, Cardiology Division, Inc. Self-actuating sealing portions for paravalvular leak protection
US8986375B2 (en) 2013-03-12 2015-03-24 Medtronic, Inc. Anti-paravalvular leakage component for a transcatheter valve prosthesis
US9636222B2 (en) 2013-03-12 2017-05-02 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak protection
WO2014164364A1 (en) 2013-03-13 2014-10-09 Aortic Innovations, Llc Dual frame stent and valve devices and implantation
US20140350668A1 (en) 2013-03-13 2014-11-27 Symetis Sa Prosthesis Seals and Methods for Sealing an Expandable Prosthesis
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US20140277427A1 (en) 2013-03-14 2014-09-18 Cardiaq Valve Technologies, Inc. Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US9232994B2 (en) 2013-03-15 2016-01-12 Medtronic Vascular Galway Limited Stented prosthetic heart valve and methods for making
KR20220104302A (en) 2013-03-15 2022-07-26 네비게이트 카디악 스트럭쳐스, 인크. Catheter-guided replacement valves apparatus and methods
EP4183373A1 (en) 2013-03-15 2023-05-24 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems
EP2777617B1 (en) 2013-03-15 2022-09-14 Edwards Lifesciences CardiAQ LLC Prosthesis with outer skirt
CN103190968B (en) 2013-03-18 2015-06-17 杭州启明医疗器械有限公司 Bracket and stably-mounted artificial valve displacement device with same
US9486306B2 (en) 2013-04-02 2016-11-08 Tendyne Holdings, Inc. Inflatable annular sealing device for prosthetic mitral valve
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US20140330372A1 (en) 2013-05-03 2014-11-06 Medtronic, Inc. Medical Devices for Implanting in a Valve and Associated Methods
EP2991586A1 (en) 2013-05-03 2016-03-09 Medtronic Inc. Valve delivery tool
US9375311B2 (en) 2013-05-03 2016-06-28 Medtronic, Inc. Prosthetic valves and associated appartuses, systems and methods
US9877738B2 (en) 2013-05-09 2018-01-30 Gyrus Acmi, Inc. Oscillating lithotripter
JP6515088B2 (en) 2013-05-20 2019-05-15 エドワーズ ライフサイエンシーズ コーポレイションEdwards Lifesciences Corporation Prosthetic heart valve delivery device
US20140358224A1 (en) 2013-05-30 2014-12-04 Tendyne Holdlings, Inc. Six cell inner stent device for prosthetic mitral valves
US9610159B2 (en) 2013-05-30 2017-04-04 Tendyne Holdings, Inc. Structural members for prosthetic mitral valves
US9788943B2 (en) 2013-06-11 2017-10-17 Medtronic, Inc. Delivery system with inline sheath
US9468527B2 (en) 2013-06-12 2016-10-18 Edwards Lifesciences Corporation Cardiac implant with integrated suture fasteners
US20140371844A1 (en) 2013-06-18 2014-12-18 St. Jude Medical, Cardiology Division, Inc. Transcatheter mitral valve and delivery system
WO2014204807A1 (en) 2013-06-19 2014-12-24 Aga Medical Corporation Collapsible valve having paravalvular leak protection
JP6461122B2 (en) 2013-06-25 2019-01-30 テンダイン ホールディングス,インコーポレイテッド Thrombus management and structural compliance features of prosthetic heart valves
US9668856B2 (en) 2013-06-26 2017-06-06 St. Jude Medical, Cardiology Division, Inc. Puckering seal for reduced paravalvular leakage
US10524904B2 (en) 2013-07-11 2020-01-07 Medtronic, Inc. Valve positioning device
EP2826443B1 (en) 2013-07-16 2017-06-28 Venus MedTech (HangZhou), Inc. Set comprising an apparatus and a medical implant
US8870948B1 (en) 2013-07-17 2014-10-28 Cephea Valve Technologies, Inc. System and method for cardiac valve repair and replacement
EP2832318B1 (en) 2013-07-31 2017-04-05 Venus MedTech (HangZhou), Inc. Handle assembly for implant delivery apparatus comprising a force limiter, a displacement limiter and/or a brake frame assembly
EP2918246B1 (en) 2014-03-14 2018-08-08 Venus MedTech (HangZhou), Inc. Heart valve assembly comprising twofold sealing
EP2832315B1 (en) 2013-07-31 2017-11-22 Venus MedTech (HangZhou), Inc. Handle assembly for implant delivery apparatus comprising a brake frame assembly, a force limiter and/or a displacement limiter
EP2832316B1 (en) 2013-07-31 2017-03-29 Venus MedTech (HangZhou), Inc. Handle assembly for implant delivery apparatus comprising a displacement limiter, a force limiter and/or a brake frame assembly
US10195028B2 (en) * 2013-09-10 2019-02-05 Edwards Lifesciences Corporation Magnetic retaining mechanisms for prosthetic valves
EP3046511B1 (en) 2013-09-16 2018-03-28 Symetis SA Method and apparatus for compressing/loading stent-valves
US9393111B2 (en) 2014-01-15 2016-07-19 Sino Medical Sciences Technology Inc. Device and method for mitral valve regurgitation treatment
US9839511B2 (en) 2013-10-05 2017-12-12 Sino Medical Sciences Technology Inc. Device and method for mitral valve regurgitation treatment
KR101814945B1 (en) 2013-10-15 2018-01-04 보스톤 싸이엔티픽 싸이메드 인코포레이티드 Methods and systems for loading and delivering a stent
US9925045B2 (en) 2013-10-21 2018-03-27 Medtronic Vascular Galway Systems, devices and methods for transcatheter valve delivery
US9839765B2 (en) 2013-11-12 2017-12-12 St. Jude Medical, Cardiology Division, Inc. Transfemoral mitral valve repair delivery device
US9889004B2 (en) 2013-11-19 2018-02-13 St. Jude Medical, Cardiology Division, Inc. Sealing structures for paravalvular leak protection
EP2896387A1 (en) * 2014-01-20 2015-07-22 Mitricares Heart valve anchoring device
US20150209141A1 (en) 2014-01-24 2015-07-30 St. Jude Medical, Cardiology Division, Inc. Stationary intra-annular halo designs for paravalvular leak (pvl) reduction-passive channel filling cuff designs
US9687343B2 (en) * 2014-03-11 2017-06-27 Highlife Sas Transcatheter valve prosthesis
US20150272737A1 (en) 2014-03-26 2015-10-01 St. Jude Medical, Cardiology Division, Inc. Transcatheter mitral valve stent frames
WO2015160598A1 (en) 2014-04-17 2015-10-22 Medtronic Vascular Galway Hinged transcatheter prosthetic heart valve delivery system
USRE49792E1 (en) 2014-05-14 2024-01-09 Corcym S.R.L. Implant device and implantation kit
US9532870B2 (en) * 2014-06-06 2017-01-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US9974647B2 (en) 2014-06-12 2018-05-22 Caisson Interventional, LLC Two stage anchor and mitral valve assembly
US10524910B2 (en) 2014-07-30 2020-01-07 Mitraltech Ltd. 3 Ariel Sharon Avenue Articulatable prosthetic valve
US9750605B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
US9750607B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
EP3037064B1 (en) 2014-12-23 2018-03-14 Venus MedTech (HangZhou), Inc. Minimally invasive mitral valve replacement with brim
US9861477B2 (en) 2015-01-26 2018-01-09 Boston Scientific Scimed Inc. Prosthetic heart valve square leaflet-leaflet stitch
CA3162308A1 (en) 2015-02-05 2016-08-11 Cardiovalve Ltd. Prosthetic valve with axially-sliding frames
EP3273910A2 (en) * 2015-03-24 2018-01-31 St. Jude Medical, Cardiology Division, Inc. Mitral heart valve replacement
US9782256B2 (en) * 2015-04-27 2017-10-10 Venus Medtech (Hangzhou) Inc Heart valve assembly
US10849746B2 (en) 2015-05-14 2020-12-01 Cephea Valve Technologies, Inc. Cardiac valve delivery devices and systems
WO2016201024A1 (en) * 2015-06-12 2016-12-15 St. Jude Medical, Cardiology Division, Inc. Heart valve repair and replacement
US10575951B2 (en) * 2015-08-26 2020-03-03 Edwards Lifesciences Cardiaq Llc Delivery device and methods of use for transapical delivery of replacement mitral valve
US10117744B2 (en) * 2015-08-26 2018-11-06 Edwards Lifesciences Cardiaq Llc Replacement heart valves and methods of delivery
US10470876B2 (en) * 2015-11-10 2019-11-12 Edwards Lifesciences Corporation Transcatheter heart valve for replacing natural mitral valve
JP7006940B2 (en) 2016-01-29 2022-01-24 ニオバスク ティアラ インコーポレイテッド Artificial valve to avoid blockage of outflow
US10321992B2 (en) * 2016-02-01 2019-06-18 Medtronic, Inc. Heart valve prostheses having multiple support arms and methods for percutaneous heart valve replacement
US20210212825A1 (en) * 2016-03-08 2021-07-15 Dura Llc Transcatheter valve leaflet replacement device, delivery, guiding and fixation system and method for same
US10278852B2 (en) 2016-03-10 2019-05-07 Medtronic Vascular, Inc. Steerable catheter with multiple bending radii via a steering mechanism with telescoping tubular components
US10624740B2 (en) 2016-05-13 2020-04-21 St. Jude Medical, Cardiology Division, Inc. Mitral valve delivery device
US10449044B2 (en) 2016-06-02 2019-10-22 Medtronic Vascular, Inc. Transcatheter valve delivery system with septum hole closure tip assembly
US10350062B2 (en) * 2016-07-21 2019-07-16 Edwards Lifesciences Corporation Replacement heart valve prosthesis
US11045315B2 (en) 2016-08-29 2021-06-29 Cephea Valve Technologies, Inc. Methods of steering and delivery of intravascular devices
US10905550B2 (en) * 2017-02-01 2021-02-02 Medtronic Vascular, Inc. Heart valve prostheses including torque anchoring mechanisms and delivery devices for the heart valve prostheses
US10888421B2 (en) * 2017-09-19 2021-01-12 Cardiovalve Ltd. Prosthetic heart valve with pouch
US10575948B2 (en) * 2017-08-03 2020-03-03 Cardiovalve Ltd. Prosthetic heart valve
US11337802B2 (en) * 2017-09-19 2022-05-24 Cardiovalve Ltd. Heart valve delivery systems and methods
US11051934B2 (en) * 2018-02-28 2021-07-06 Edwards Lifesciences Corporation Prosthetic mitral valve with improved anchors and seal
JP7260930B2 (en) * 2018-11-08 2023-04-19 ニオバスク ティアラ インコーポレイテッド Ventricular deployment of a transcatheter mitral valve prosthesis
EP3893804A1 (en) * 2018-12-10 2021-10-20 St. Jude Medical, Cardiology Division, Inc. Prosthetic tricuspid valve replacement design

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100249923A1 (en) * 2007-09-28 2010-09-30 St Jude Medical Inc. Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features
US20090287299A1 (en) * 2008-01-24 2009-11-19 Charles Tabor Stents for prosthetic heart valves
US20120215303A1 (en) * 2009-09-29 2012-08-23 Cardiaq Valve Technologies, Inc. Replacement heart valve and method
US20110313515A1 (en) * 2010-06-21 2011-12-22 Arshad Quadri Replacement heart valve
US20120022640A1 (en) * 2010-07-21 2012-01-26 Yossi Gross Techniques for percutaneous mitral valve replacement and sealing
WO2012177942A2 (en) * 2011-06-21 2012-12-27 Hanson Gifford, Iii Prosthetic heart valve devices and associated systems and methods

Cited By (338)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9974669B2 (en) 2005-11-10 2018-05-22 Edwards Lifesciences Cardiaq Llc Percutaneous heart valve
US9486336B2 (en) 2005-11-10 2016-11-08 Edwards Lifesciences Cardiaq Llc Prosthesis having a plurality of distal and proximal prongs
US9433514B2 (en) 2005-11-10 2016-09-06 Edwards Lifesciences Cardiaq Llc Method of securing a prosthesis
US10456277B2 (en) 2005-11-10 2019-10-29 Edwards Lifesciences Cardiaq Llc Percutaneous heart valve
US10350065B2 (en) 2006-07-28 2019-07-16 Edwards Lifesciences Cardiaq Llc Percutaneous valve prosthesis and system and method for implanting the same
US11141265B2 (en) 2006-07-28 2021-10-12 Edwards Lifesciences Cardiaq Llc Percutaneous valve prosthesis and system and method for implanting the same
US9192471B2 (en) 2007-01-08 2015-11-24 Millipede, Inc. Device for translumenal reshaping of a mitral valve annulus
US9456896B2 (en) * 2008-09-29 2016-10-04 Edwards Lifesciences Cardiaq Llc Body cavity prosthesis
US11819404B2 (en) 2008-09-29 2023-11-21 Edwards Lifesciences Cardiaq Llc Heart valve
US20130131793A1 (en) * 2008-09-29 2013-05-23 Cardiaq Valve Technologies, Inc. Replacement heart valve and method
US20130131788A1 (en) * 2008-09-29 2013-05-23 Cardiaq Valve Technologies, Inc. Body cavity prosthesis
US8894702B2 (en) * 2008-09-29 2014-11-25 Cardiaq Valve Technologies, Inc. Replacement heart valve and method
US10646334B2 (en) 2008-09-29 2020-05-12 Edwards Lifesciences Cardiaq Llc Heart valve
US10149756B2 (en) 2008-09-29 2018-12-11 Edwards Lifesciences Cardiaq Llc Heart valve
US11589983B2 (en) 2008-09-29 2023-02-28 Edwards Lifesciences Cardiaq Llc Heart valve
US20130184813A1 (en) * 2008-09-29 2013-07-18 Cardiaq Valve Technologies, Inc. Body cavity prosthesis
US9339377B2 (en) * 2008-09-29 2016-05-17 Edwards Lifesciences Cardiaq Llc Body cavity prosthesis
US9597183B2 (en) 2008-10-01 2017-03-21 Edwards Lifesciences Cardiaq Llc Delivery system for vascular implant
US9333073B2 (en) 2009-04-15 2016-05-10 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery method
US9339379B2 (en) 2009-04-15 2016-05-17 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9339378B2 (en) 2009-04-15 2016-05-17 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9339380B2 (en) 2009-04-15 2016-05-17 Edwards Lifesciences Cardiaq Llc Vascular implant
US9333074B2 (en) 2009-04-15 2016-05-10 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US10441412B2 (en) 2009-04-15 2019-10-15 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US11376119B2 (en) 2009-04-15 2022-07-05 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9585747B2 (en) 2009-04-15 2017-03-07 Edwards Lifesciences Cardiaq Llc Vascular implant
US9730790B2 (en) 2009-09-29 2017-08-15 Edwards Lifesciences Cardiaq Llc Replacement valve and method
US10524901B2 (en) 2009-09-29 2020-01-07 Edwards Lifesciences Cardiaq Llc Replacement heart valve
US10166097B2 (en) 2009-09-29 2019-01-01 Edwards Lifesciences Cardiaq Llc Replacement heart valve and method
US11911264B2 (en) 2009-12-04 2024-02-27 Edwards Lifesciences Corporation Valve repair and replacement devices
US11660185B2 (en) 2009-12-04 2023-05-30 Edwards Lifesciences Corporation Ventricular anchors for valve repair and replacement devices
US10231831B2 (en) 2009-12-08 2019-03-19 Cardiovalve Ltd. Folding ring implant for heart valve
US10548726B2 (en) 2009-12-08 2020-02-04 Cardiovalve Ltd. Rotation-based anchoring of an implant
US11351026B2 (en) 2009-12-08 2022-06-07 Cardiovalve Ltd. Rotation-based anchoring of an implant
US11839541B2 (en) 2009-12-08 2023-12-12 Cardiovalve Ltd. Prosthetic heart valve with upper skirt
US11141268B2 (en) 2009-12-08 2021-10-12 Cardiovalve Ltd. Prosthetic heart valve with upper and lower skirts
US10660751B2 (en) 2009-12-08 2020-05-26 Cardiovalve Ltd. Prosthetic heart valve with upper skirt
US10405978B2 (en) 2010-01-22 2019-09-10 4Tech Inc. Tricuspid valve repair using tension
US10433963B2 (en) 2010-01-22 2019-10-08 4Tech Inc. Tissue anchor and delivery tool
US10058323B2 (en) 2010-01-22 2018-08-28 4 Tech Inc. Tricuspid valve repair using tension
US10238491B2 (en) 2010-01-22 2019-03-26 4Tech Inc. Tricuspid valve repair using tension
US9072603B2 (en) * 2010-02-24 2015-07-07 Medtronic Ventor Technologies, Ltd. Mitral prosthesis and methods for implantation
US9788941B2 (en) 2010-03-10 2017-10-17 Mitraltech Ltd. Axially-shortening prosthetic valve
US11109964B2 (en) 2010-03-10 2021-09-07 Cardiovalve Ltd. Axially-shortening prosthetic valve
US9248014B2 (en) 2010-05-05 2016-02-02 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US11419720B2 (en) 2010-05-05 2022-08-23 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US9241790B2 (en) 2010-05-05 2016-01-26 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US10449042B2 (en) 2010-05-05 2019-10-22 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US9770329B2 (en) 2010-05-05 2017-09-26 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US11432924B2 (en) 2010-05-05 2022-09-06 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US11452597B2 (en) 2010-06-21 2022-09-27 Edwards Lifesciences Cardiaq Llc Replacement heart valve
US10485660B2 (en) 2010-06-21 2019-11-26 Edwards Lifesciences Cardiaq Llc Replacement heart valve
US10639146B2 (en) 2010-06-21 2020-05-05 Edwards Lifesciences Cardiaq Llc Replacement heart valve
US10512456B2 (en) 2010-07-21 2019-12-24 Cardiovalve Ltd. Techniques for percutaneous mitral valve replacement and sealing
US11426155B2 (en) 2010-07-21 2022-08-30 Cardiovalve Ltd. Helical anchor implantation
US11653910B2 (en) 2010-07-21 2023-05-23 Cardiovalve Ltd. Helical anchor implantation
US10925595B2 (en) 2010-07-21 2021-02-23 Cardiovalve Ltd. Valve prosthesis configured for deployment in annular spacer
US9763657B2 (en) 2010-07-21 2017-09-19 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US10531872B2 (en) 2010-07-21 2020-01-14 Cardiovalve Ltd. Valve prosthesis configured for deployment in annular spacer
US9795480B2 (en) 2010-08-24 2017-10-24 Millipede, Inc. Reconfiguring tissue features of a heart annulus
US20140088696A1 (en) * 2011-01-11 2014-03-27 Hans Reiner Figulla Prosthetic valve for replacing an atrioventricular heart valve
US9125738B2 (en) * 2011-01-11 2015-09-08 Hans Reiner Figulla Prosthetic valve for replacing an atrioventricular heart valve
US9713529B2 (en) 2011-04-28 2017-07-25 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US10376361B2 (en) 2011-08-05 2019-08-13 Cardiovalve Ltd. Techniques for percutaneous mitral valve replacement and sealing
US10245143B2 (en) 2011-08-05 2019-04-02 Cardiovalve Ltd. Techniques for percutaneous mitral valve replacement and sealing
US10702385B2 (en) 2011-08-05 2020-07-07 Cardiovalve Ltd. Implant for heart valve
US11517429B2 (en) 2011-08-05 2022-12-06 Cardiovalve Ltd. Apparatus for use at a heart valve
US11517436B2 (en) 2011-08-05 2022-12-06 Cardiovalve Ltd. Implant for heart valve
US10226341B2 (en) 2011-08-05 2019-03-12 Cardiovalve Ltd. Implant for heart valve
US11344410B2 (en) 2011-08-05 2022-05-31 Cardiovalve Ltd. Implant for heart valve
US11690712B2 (en) 2011-08-05 2023-07-04 Cardiovalve Ltd. Clip-secured implant for heart valve
US11291547B2 (en) 2011-08-05 2022-04-05 Cardiovalve Ltd. Leaflet clip with collars
US11864995B2 (en) 2011-08-05 2024-01-09 Cardiovalve Ltd. Implant for heart valve
US10695173B2 (en) 2011-08-05 2020-06-30 Cardiovalve Ltd. Techniques for percutaneous mitral valve replacement and sealing
US11291545B2 (en) 2011-08-05 2022-04-05 Cardiovalve Ltd. Implant for heart valve
US11291546B2 (en) 2011-08-05 2022-04-05 Cardiovalve Ltd. Leaflet clip with collars
US11369469B2 (en) 2011-08-05 2022-06-28 Cardiovalve Ltd. Method for use at a heart valve
US11413139B2 (en) 2011-11-23 2022-08-16 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US10537422B2 (en) 2011-11-23 2020-01-21 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US11497602B2 (en) 2012-02-14 2022-11-15 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US10363133B2 (en) 2012-02-14 2019-07-30 Neovac Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US10016275B2 (en) 2012-05-30 2018-07-10 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US11389294B2 (en) 2012-05-30 2022-07-19 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9345573B2 (en) * 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US10314705B2 (en) 2012-05-30 2019-06-11 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US11617650B2 (en) 2012-05-30 2023-04-04 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US10940001B2 (en) 2012-05-30 2021-03-09 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US10849755B2 (en) 2012-09-14 2020-12-01 Boston Scientific Scimed, Inc. Mitral valve inversion prostheses
US10543088B2 (en) 2012-09-14 2020-01-28 Boston Scientific Scimed, Inc. Mitral valve inversion prostheses
US10500040B2 (en) 2012-11-13 2019-12-10 Cardiovalve Ltd. Percutaneously-deliverable dual-frame valve
US10045845B2 (en) 2012-11-13 2018-08-14 Mitraltech Ltd. Percutaneously-deliverable mechanical valve
US10449050B2 (en) 2013-01-09 2019-10-22 4 Tech Inc. Soft tissue depth-finding tool
US9788948B2 (en) 2013-01-09 2017-10-17 4 Tech Inc. Soft tissue anchors and implantation techniques
US9693865B2 (en) 2013-01-09 2017-07-04 4 Tech Inc. Soft tissue depth-finding tool
US10835377B2 (en) 2013-01-24 2020-11-17 Cardiovalve Ltd. Rolled prosthetic valve support
US9681952B2 (en) 2013-01-24 2017-06-20 Mitraltech Ltd. Anchoring of prosthetic valve supports
US10631982B2 (en) 2013-01-24 2020-04-28 Cardiovale Ltd. Prosthetic valve and upstream support therefor
US11844691B2 (en) 2013-01-24 2023-12-19 Cardiovalve Ltd. Partially-covered prosthetic valves
US10583002B2 (en) 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
US10583000B2 (en) 2013-03-14 2020-03-10 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US11324591B2 (en) 2013-03-14 2022-05-10 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9907681B2 (en) 2013-03-14 2018-03-06 4Tech Inc. Stent with tether interface
US10716664B2 (en) 2013-03-14 2020-07-21 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US10383728B2 (en) 2013-04-04 2019-08-20 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US11389291B2 (en) 2013-04-04 2022-07-19 Neovase Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US9724083B2 (en) 2013-07-26 2017-08-08 Edwards Lifesciences Cardiaq Llc Systems and methods for sealing openings in an anatomical wall
US10022114B2 (en) 2013-10-30 2018-07-17 4Tech Inc. Percutaneous tether locking
US10052095B2 (en) 2013-10-30 2018-08-21 4Tech Inc. Multiple anchoring-point tension system
US10271946B2 (en) 2014-02-18 2019-04-30 St. Jude Medical, Cardiology Division, Inc. Bowed runners and corresponding valve assemblies for paravalvular leak protection
US20190209303A1 (en) * 2014-02-18 2019-07-11 St. Jude Medical, Cardiology Division, Inc. Bowed Runners and Corresponding Valve Assemblies for Paravalvular Leak Protection
US9949825B2 (en) * 2014-02-18 2018-04-24 St. Jude Medical, Cardiology Division, Inc. Bowed runners and corresponding valve assemblies for paravalvular leak protection
US20160361160A1 (en) * 2014-02-18 2016-12-15 St. Jude Medical, Cardiology Division, Inc. Bowed runners and corresponding valve assemblies for paravalvular leak protection
US10952847B2 (en) * 2014-02-18 2021-03-23 St. Jude Medical, Cardiology Division, Inc. Bowed runners and corresponding valve assemblies for paravalvular leak protection
US10952849B2 (en) 2014-02-21 2021-03-23 Edwards Lifesciences Cardiaq Llc Prosthesis, delivery device and methods of use
US10004599B2 (en) 2014-02-21 2018-06-26 Edwards Lifesciences Cardiaq Llc Prosthesis, delivery device and methods of use
US11633279B2 (en) 2014-02-21 2023-04-25 Edwards Lifesciences Cardiaq Llc Prosthesis, delivery device and methods of use
WO2015127283A1 (en) 2014-02-21 2015-08-27 Cardiaq Valve Technologies, Inc. Delivery device for controlled deployement of a replacement valve
US10064719B2 (en) * 2014-03-11 2018-09-04 Highlife Sas Transcatheter valve prosthesis
US20150257882A1 (en) * 2014-03-11 2015-09-17 Highlife Sas Transcatheter valve prosthesis
US20210315692A1 (en) * 2014-05-19 2021-10-14 Edwards Lifesciences Cardiaq Llc Replacement heart valve
US11045313B2 (en) 2014-05-19 2021-06-29 Edwards Lifesciences Cardiaq Llc Replacement mitral valve
WO2015179423A1 (en) 2014-05-19 2015-11-26 Cardiaq Valve Technologies, Inc. Replacement mitral valve with annular flap
US10179044B2 (en) 2014-05-19 2019-01-15 Edwards Lifesciences Cardiaq Llc Replacement mitral valve
US10010414B2 (en) * 2014-06-06 2018-07-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US11684471B2 (en) 2014-06-06 2023-06-27 Edwards Lifesciences Corporation Prosthetic valve for replacing a native mitral or tricuspid valve
US20170095328A1 (en) * 2014-06-06 2017-04-06 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US10687939B2 (en) 2014-06-06 2020-06-23 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US9801720B2 (en) 2014-06-19 2017-10-31 4Tech Inc. Cardiac tissue cinching
US9615926B2 (en) 2014-07-17 2017-04-11 Millipede, Inc. Adjustable endolumenal implant for reshaping the mitral valve annulus
US9913706B2 (en) 2014-07-17 2018-03-13 Millipede, Inc. Adjustable endolumenal implant for reshaping the mitral valve annulus
US9622862B2 (en) 2014-07-17 2017-04-18 Millipede, Inc. Prosthetic mitral valve with adjustable support
US10136985B2 (en) 2014-07-17 2018-11-27 Millipede, Inc. Method of reconfiguring a mitral valve annulus
US9180005B1 (en) 2014-07-17 2015-11-10 Millipede, Inc. Adjustable endolumenal mitral valve ring
US10695160B2 (en) 2014-07-17 2020-06-30 Boston Scientific Scimed, Inc. Adjustable endolumenal implant for reshaping the mitral valve annulus
US10492908B2 (en) 2014-07-30 2019-12-03 Cardiovalve Ltd. Anchoring of a prosthetic valve
US10524910B2 (en) 2014-07-30 2020-01-07 Mitraltech Ltd. 3 Ariel Sharon Avenue Articulatable prosthetic valve
US11872130B2 (en) 2014-07-30 2024-01-16 Cardiovalve Ltd. Prosthetic heart valve implant
US11701225B2 (en) 2014-07-30 2023-07-18 Cardiovalve Ltd. Delivery of a prosthetic valve
US9907547B2 (en) 2014-12-02 2018-03-06 4Tech Inc. Off-center tissue anchors
US11690621B2 (en) 2014-12-04 2023-07-04 Edwards Lifesciences Corporation Percutaneous clip for repairing a heart valve
US10463483B2 (en) * 2014-12-19 2019-11-05 Venus Medtech (Hangzhou) Inc. Minimally invasive mitral valve replacement with brim
US10918481B2 (en) 2015-02-05 2021-02-16 Cardiovalve Ltd. Techniques for deployment of a prosthetic valve
US11672658B2 (en) 2015-02-05 2023-06-13 Cardiovalve Ltd. Prosthetic valve with aligned inner and outer frames
US10507105B2 (en) 2015-02-05 2019-12-17 Cardiovalve Ltd. Prosthetic valve with tissue anchors free from lateral interconnections
US10667908B2 (en) 2015-02-05 2020-06-02 Cardiovalve Ltd. Prosthetic valve with S-shaped tissue anchors
US10682227B2 (en) 2015-02-05 2020-06-16 Cardiovalve Ltd. Prosthetic valve with pivoting tissue anchor portions
US10463488B2 (en) 2015-02-05 2019-11-05 Cardiovalve Ltd. Prosthetic valve with separably-deployable valve body and tissue anchors
US10695177B2 (en) 2015-02-05 2020-06-30 Cardiovalve Ltd. Prosthetic valve with aligned inner and outer frames
US10864078B2 (en) 2015-02-05 2020-12-15 Cardiovalve Ltd. Prosthetic valve with separably-deployable valve body and tissue anchors
US10463487B2 (en) 2015-02-05 2019-11-05 Cardiovalve Ltd. Prosthetic valve delivery system with independently-movable capsule portions
US10390952B2 (en) 2015-02-05 2019-08-27 Cardiovalve Ltd. Prosthetic valve with flexible tissue anchor portions
US10357360B2 (en) 2015-02-05 2019-07-23 Cardiovalve Ltd. Prosthetic valve with aligned inner and outer frames
US10722360B2 (en) 2015-02-05 2020-07-28 Cardiovalve Ltd. Prosthetic valve with radially-deflectable tissue anchors
US11534298B2 (en) 2015-02-05 2022-12-27 Cardiovalve Ltd. Prosthetic valve with s-shaped tissue anchors
US10736742B2 (en) 2015-02-05 2020-08-11 Cardiovalve Ltd. Prosthetic valve with atrial arms
US9974651B2 (en) 2015-02-05 2018-05-22 Mitral Tech Ltd. Prosthetic valve with axially-sliding frames
US10888422B2 (en) 2015-02-05 2021-01-12 Cardiovalve Ltd. Prosthetic valve with flexible tissue anchor portions
US11793635B2 (en) 2015-02-05 2023-10-24 Cardiovalve Ltd. Prosthetic valve with angularly offset frames
US10758344B2 (en) 2015-02-05 2020-09-01 Cardiovalve Ltd. Prosthetic valve with angularly offset frames
US10449047B2 (en) 2015-02-05 2019-10-22 Cardiovalve Ltd. Prosthetic heart valve with compressible frames
US10524903B2 (en) 2015-02-05 2020-01-07 Cardiovalve Ltd. Prosthetic valve with aligned inner and outer frames
US10973636B2 (en) 2015-02-05 2021-04-13 Cardiovalve Ltd. Prosthetic valve with tissue anchors free from lateral interconnections
US11801135B2 (en) 2015-02-05 2023-10-31 Cardiovalve Ltd. Techniques for deployment of a prosthetic valve
US11793638B2 (en) 2015-02-05 2023-10-24 Cardiovalve Ltd. Prosthetic valve with pivoting tissue anchor portions
US10849748B2 (en) 2015-02-05 2020-12-01 Cardiovalve Ltd. Prosthetic valve delivery system with independently-movable capsule portions
US10426610B2 (en) 2015-02-05 2019-10-01 Cardiovalve Ltd. Prosthetic valve with radially-deflectable tissue anchors
US10258466B2 (en) 2015-02-13 2019-04-16 Millipede, Inc. Valve replacement using moveable restrains and angled struts
US9848983B2 (en) 2015-02-13 2017-12-26 Millipede, Inc. Valve replacement using rotational anchors
US10743992B2 (en) * 2015-03-24 2020-08-18 St. Jude Medical, Cardiology Division, Inc. Prosthetic mitral valve
US11850147B2 (en) 2015-04-21 2023-12-26 Edwards Lifesciences Corporation Percutaneous mitral valve replacement device
US10441416B2 (en) 2015-04-21 2019-10-15 Edwards Lifesciences Corporation Percutaneous mitral valve replacement device
US11389292B2 (en) 2015-04-30 2022-07-19 Edwards Lifesciences Cardiaq Llc Replacement mitral valve, delivery system for replacement mitral valve and methods of use
US10376363B2 (en) 2015-04-30 2019-08-13 Edwards Lifesciences Cardiaq Llc Replacement mitral valve, delivery system for replacement mitral valve and methods of use
WO2016176610A1 (en) 2015-04-30 2016-11-03 Edwards Lifesciences Cardiaq Llc Replacement mitral valve, delivery system for replacement mitral valve and methods of use
EP3967272A1 (en) 2015-04-30 2022-03-16 Edwards Lifesciences CardiAQ LLC Replacement mitral valve and delivery system for replacement mitral valve
US11793642B2 (en) 2015-05-14 2023-10-24 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US10736740B2 (en) * 2015-05-25 2020-08-11 Venus Medtech (Hangzhou) Inc. Transcatheter pulmonary ball valve assembly
JP2021104347A (en) * 2015-05-25 2021-07-26 ヴィーナス メドテック (ハンゾウ)インコーポレーテッドVenus Medtech (Hangzhou), Inc. Transcatheter pulmonary artery ball valve assembly
US20170086973A1 (en) * 2015-05-25 2017-03-30 Horizon Scientific Corp. Transcatheter Pulmonary Ball Valve Assembly
JP7150924B2 (en) 2015-05-25 2022-10-11 杭州啓明医療器械股▲ふん▼有限公司 Transcatheter Pulmonary Ball Valve Assembly
US20190000616A1 (en) * 2015-05-25 2019-01-03 Venus Medtech (Hangzhou), Inc. Transcatheter Pulmonary Ball Valve Assembly
US10052202B2 (en) * 2015-05-25 2018-08-21 Venus Medtech (Hangzhou) Inc Transcatheter pulmonary ball valve assembly
JP2018519138A (en) * 2015-05-25 2018-07-19 ヴィーナス メドテック (ハンゾウ)インコーポレーテッドVenus Medtech (Hangzhou), Inc. Transcatheter pulmonary valve assembly
US10226335B2 (en) 2015-06-22 2019-03-12 Edwards Lifesciences Cardiaq Llc Actively controllable heart valve implant and method of controlling same
US11083576B2 (en) 2015-06-22 2021-08-10 Edwards Lifesciences Cardiaq Llc Actively controllable heart valve implant and method of controlling same
US10092400B2 (en) 2015-06-23 2018-10-09 Edwards Lifesciences Cardiaq Llc Systems and methods for anchoring and sealing a prosthetic heart valve
US10842620B2 (en) 2015-06-23 2020-11-24 Edwards Lifesciences Cardiaq Llc Systems and methods for anchoring and sealing a prosthetic heart valve
US11844690B2 (en) 2015-06-23 2023-12-19 Edwards Lifesciences Cardiaq Llc Systems and methods for anchoring and sealing a prosthetic heart valve
EP4032504A1 (en) 2015-08-26 2022-07-27 Edwards Lifesciences CardiAQ LLC Replacement heart valves
US10758345B2 (en) 2015-08-26 2020-09-01 Edwards Lifesciences Cardiaq Llc Replacement heart valves and methods of delivery
US10117744B2 (en) 2015-08-26 2018-11-06 Edwards Lifesciences Cardiaq Llc Replacement heart valves and methods of delivery
EP4074286A1 (en) 2015-08-26 2022-10-19 Edwards Lifesciences CardiAQ LLC Replacement heart valves
US11278405B2 (en) 2015-08-26 2022-03-22 Edwards Lifesciences Cardiaq Llc Delivery device and methods of use for transapical delivery of replacement valve
EP3692950A1 (en) 2015-08-26 2020-08-12 Edwards Lifesciences CardiAQ LLC Replacement heart valves
US10575951B2 (en) 2015-08-26 2020-03-03 Edwards Lifesciences Cardiaq Llc Delivery device and methods of use for transapical delivery of replacement mitral valve
EP3834777A1 (en) 2015-08-28 2021-06-16 Edwards Lifesciences CardiAQ LLC Steerable delivery system for replacement mitral valve
US10350066B2 (en) 2015-08-28 2019-07-16 Edwards Lifesciences Cardiaq Llc Steerable delivery system for replacement mitral valve and methods of use
US11253364B2 (en) 2015-08-28 2022-02-22 Edwards Lifesciences Cardiaq Llc Steerable delivery system for replacement mitral valve and methods of use
US10335275B2 (en) 2015-09-29 2019-07-02 Millipede, Inc. Methods for delivery of heart valve devices using intravascular ultrasound imaging
US10555813B2 (en) 2015-11-17 2020-02-11 Boston Scientific Scimed, Inc. Implantable device and delivery system for reshaping a heart valve annulus
US11219746B2 (en) 2016-03-21 2022-01-11 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
USD815744S1 (en) 2016-04-28 2018-04-17 Edwards Lifesciences Cardiaq Llc Valve frame for a delivery system
US11224507B2 (en) 2016-07-21 2022-01-18 Edwards Lifesciences Corporation Replacement heart valve prosthesis
US20180021129A1 (en) * 2016-07-21 2018-01-25 Edwards Lifesciences Corporation Replacement heart valve prosthesis
WO2018017886A1 (en) 2016-07-21 2018-01-25 Edwards Lifesciences Corporation Replacement heart valve prosthesis
EP4212130A1 (en) 2016-07-21 2023-07-19 Edwards Lifesciences Corporation Replacement heart valve prosthesis
US10350062B2 (en) * 2016-07-21 2019-07-16 Edwards Lifesciences Corporation Replacement heart valve prosthesis
US11779458B2 (en) 2016-08-10 2023-10-10 Cardiovalve Ltd. Prosthetic valve with leaflet connectors
US10856975B2 (en) 2016-08-10 2020-12-08 Cardiovalve Ltd. Prosthetic valve with concentric frames
US10646340B2 (en) 2016-08-19 2020-05-12 Edwards Lifesciences Corporation Steerable delivery system for replacement mitral valve
WO2018035375A1 (en) 2016-08-19 2018-02-22 Edwards Lifesciences Corporation Steerable delivery system for replacement mitral valve and methods of use
EP3964173A1 (en) 2016-08-26 2022-03-09 Edwards Lifesciences Corporation Multi-portion replacement heart valve prosthesis
CN109843219A (en) * 2016-08-26 2019-06-04 爱德华兹生命科学公司 Multi-section, which is split, changes heart valve prosthesis
US11504229B2 (en) 2016-08-26 2022-11-22 Edwards Lifesciences Corporation Multi-portion replacement heart valve prosthesis
EP3503848A4 (en) * 2016-08-26 2019-07-31 Edwards Lifesciences Corporation Multi-portion replacement heart valve prosthesis
US10639143B2 (en) 2016-08-26 2020-05-05 Edwards Lifesciences Corporation Multi-portion replacement heart valve prosthesis
WO2018039631A1 (en) 2016-08-26 2018-03-01 Edwards Lifesciences Corporation Multi-portion replacement heat valve prosthesis
US11510778B2 (en) 2016-11-02 2022-11-29 Edwards Lifesciences Corporation Supra and sub-annular mitral valve delivery system
US10758348B2 (en) 2016-11-02 2020-09-01 Edwards Lifesciences Corporation Supra and sub-annular mitral valve delivery system
US11141266B2 (en) 2016-11-04 2021-10-12 Highlife Sas Transcatheter valve prosthesis
US10456247B2 (en) 2016-11-04 2019-10-29 Highlife Sas Transcatheter valve prosthesis
US10736739B2 (en) 2016-11-04 2020-08-11 Highlife Sas Transcatheter valve prosthesis
US10188514B2 (en) * 2016-11-04 2019-01-29 Highlife Sas Transcatheter valve prosthesis
US9999502B2 (en) 2016-11-04 2018-06-19 Highlife Sas Transcather valve prosthesis
US11376121B2 (en) 2016-11-04 2022-07-05 Highlife Sas Transcatheter valve prosthesis
US20180125647A1 (en) * 2016-11-04 2018-05-10 Highlife Sas Transcatheter valve prosthesis
US10195027B2 (en) 2016-11-04 2019-02-05 Highlife Sas Transcatheter valve prosthesis
US11517718B2 (en) 2016-11-07 2022-12-06 Edwards Lifesciences Corporation Apparatus for the introduction and manipulation of multiple telescoping catheters
US20180133011A1 (en) * 2016-11-14 2018-05-17 Laboratoires Invalv Implant for treating a biological valve
US10905550B2 (en) 2017-02-01 2021-02-02 Medtronic Vascular, Inc. Heart valve prostheses including torque anchoring mechanisms and delivery devices for the heart valve prostheses
US11833043B2 (en) 2017-02-01 2023-12-05 Medtronic Vascular, Inc. Heart valve prostheses including torque anchoring mechanisms and delivery devices for the heart valve prostheses
US10548731B2 (en) 2017-02-10 2020-02-04 Boston Scientific Scimed, Inc. Implantable device and delivery system for reshaping a heart valve annulus
US11000373B2 (en) * 2017-04-18 2021-05-11 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11096784B2 (en) 2017-04-18 2021-08-24 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11234822B2 (en) 2017-04-18 2022-02-01 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11224511B2 (en) 2017-04-18 2022-01-18 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11850153B2 (en) 2017-04-18 2023-12-26 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11723772B2 (en) 2017-04-18 2023-08-15 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11179240B2 (en) 2017-04-18 2021-11-23 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11058539B2 (en) 2017-04-18 2021-07-13 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11160657B2 (en) 2017-04-18 2021-11-02 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11602431B2 (en) 2017-04-18 2023-03-14 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11166778B2 (en) 2017-04-28 2021-11-09 Edwards Lifesciences Corporation Medical device stabilizing apparatus and method of use
US11406468B2 (en) 2017-04-28 2022-08-09 Edwards Lifesciences Corporation Medical device stabilizing apparatus and method of use
US20220218468A1 (en) * 2017-05-31 2022-07-14 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
US11883281B2 (en) * 2017-05-31 2024-01-30 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
US20220087817A1 (en) * 2017-06-30 2022-03-24 Ohio State Innovation Foundation Prosthetic Heart Valve with Tri-Leaflet Design for Use in Percutaneous Valve Replacement Procedures
US11224509B2 (en) * 2017-06-30 2022-01-18 Ohio State Innovation Foundation Prosthetic heart valve with tri-leaflet design for use in percutaneous valve replacement procedures
US10813757B2 (en) 2017-07-06 2020-10-27 Edwards Lifesciences Corporation Steerable rail delivery system
US11883287B2 (en) 2017-07-06 2024-01-30 Edwards Lifesciences Corporation Steerable rail delivery system
US11123186B2 (en) 2017-07-06 2021-09-21 Edwards Lifesciences Corporation Steerable delivery system and components
EP4112009A1 (en) 2017-07-06 2023-01-04 Edwards Lifesciences Corporation Steerable rail delivery system
US11793633B2 (en) 2017-08-03 2023-10-24 Cardiovalve Ltd. Prosthetic heart valve
US11571298B2 (en) 2017-08-03 2023-02-07 Cardiovalve Ltd. Prosthetic valve with appendages
USD841813S1 (en) 2017-08-03 2019-02-26 Cardiovalve Ltd. Prosthetic heart valve element
US11246704B2 (en) 2017-08-03 2022-02-15 Cardiovalve Ltd. Prosthetic heart valve
US10575948B2 (en) 2017-08-03 2020-03-03 Cardiovalve Ltd. Prosthetic heart valve
US10537426B2 (en) 2017-08-03 2020-01-21 Cardiovalve Ltd. Prosthetic heart valve
USD841812S1 (en) 2017-08-03 2019-02-26 Cardiovalve Ltd. Prosthetic heart valve element
US10898319B2 (en) * 2017-08-17 2021-01-26 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
US20190053894A1 (en) * 2017-08-17 2019-02-21 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
US11730598B2 (en) 2017-09-07 2023-08-22 Edwards Lifesciences Corporation Prosthetic device for heart valve
US11304804B2 (en) 2017-09-19 2022-04-19 Cardiovalve, Ltd. Prosthetic valve with connecting struts of variable size and tissue anchoring legs of variable size that extend from junctions
US10856972B2 (en) 2017-09-19 2020-12-08 Cardiovalve Ltd. Prosthetic valve with angularly offset atrial anchoring arms and ventricular anchoring legs
US10905548B2 (en) * 2017-09-19 2021-02-02 Cardio Valve Ltd. Prosthetic valve with protective sleeve around an outlet rim
US11110251B2 (en) 2017-09-19 2021-09-07 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
US20190083249A1 (en) * 2017-09-19 2019-03-21 Cardiovalve Ltd. Prosthetic valve with inflatable cuff configured to fill a volume between atrial and ventricular tissue anchors
US11864996B2 (en) 2017-09-19 2024-01-09 Cardiovalve Ltd. Prosthetic valve with protective sleeve around an outlet rim
US10905549B2 (en) 2017-09-19 2021-02-02 Cardiovalve Ltd. Prosthetic valve with overlapping atrial tissue anchors and ventricular tissue anchors
US11337802B2 (en) 2017-09-19 2022-05-24 Cardiovalve Ltd. Heart valve delivery systems and methods
US20190083246A1 (en) * 2017-09-19 2019-03-21 Cardiovalve Ltd. Prosthetic valve with protective sleeve around an outlet rim
US11304805B2 (en) * 2017-09-19 2022-04-19 Cardiovalve Ltd. Prosthetic valve with inflatable cuff configured to fill a volume between atrial and ventricular tissue anchors
US11337803B2 (en) 2017-09-19 2022-05-24 Cardiovalve Ltd. Prosthetic valve with inner and outer frames connected at a location of tissue anchor portion
US10888421B2 (en) 2017-09-19 2021-01-12 Cardiovalve Ltd. Prosthetic heart valve with pouch
US11819405B2 (en) 2017-09-19 2023-11-21 Cardiovalve Ltd. Prosthetic valve with inflatable cuff configured for radial extension
US10799345B2 (en) 2017-09-19 2020-10-13 Cardiovalve Ltd. Prosthetic valve with protective fabric covering around tissue anchor bases
US11318015B2 (en) 2017-09-19 2022-05-03 Cardiovalve Ltd. Prosthetic valve configured to fill a volume between tissue anchors with native valve tissue
US11304806B2 (en) 2017-09-19 2022-04-19 Cardiovalve Ltd. Prosthetic valve with atrial tissue anchors having variable flexibility and ventricular tissue anchors having constant flexibility
US10881511B2 (en) 2017-09-19 2021-01-05 Cardiovalve Ltd. Prosthetic valve with tissue anchors configured to exert opposing clamping forces on native valve tissue
US11318014B2 (en) 2017-09-19 2022-05-03 Cardiovalve Ltd. Prosthetic valve delivery system with multi-planar steering
US11337804B2 (en) 2017-09-19 2022-05-24 Cardiovalve Ltd. Prosthetic valve with radially-deformable tissue anchors configured to restrict axial valve migration
US11382746B2 (en) 2017-12-13 2022-07-12 Cardiovalve Ltd. Prosthetic valve and delivery tool therefor
US11872131B2 (en) 2017-12-13 2024-01-16 Cardiovalve Ltd. Prosthetic valve and delivery tool therefor
US11547564B2 (en) 2018-01-09 2023-01-10 Edwards Lifesciences Corporation Native valve repair devices and procedures
US11013598B2 (en) 2018-01-09 2021-05-25 Edwards Lifesciences Corporation Native valve repair devices and procedures
US11850154B2 (en) 2018-01-09 2023-12-26 Edwards Lifesciences Corporation Native valve repair devices and procedures
US11612485B2 (en) 2018-01-09 2023-03-28 Edwards Lifesciences Corporation Native valve repair devices and procedures
US11259927B2 (en) 2018-01-09 2022-03-01 Edwards Lifesciences Corporation Native valve repair devices and procedures
US11298228B2 (en) 2018-01-09 2022-04-12 Edwards Lifesciences Corporation Native valve repair devices and procedures
US11872124B2 (en) 2018-01-10 2024-01-16 Cardiovalve Ltd. Temperature-control during crimping of an implant
US11633277B2 (en) 2018-01-10 2023-04-25 Cardiovalve Ltd. Temperature-control during crimping of an implant
US11478351B2 (en) 2018-01-22 2022-10-25 Edwards Lifesciences Corporation Heart shape preserving anchor
WO2019144121A1 (en) 2018-01-22 2019-07-25 Edwards Lifesciences Corporation Heart shape preserving anchor
US11684474B2 (en) 2018-01-25 2023-06-27 Edwards Lifesciences Corporation Delivery system for aided replacement valve recapture and repositioning post-deployment
WO2019147846A2 (en) 2018-01-25 2019-08-01 Edwards Lifesciences Corporation Delivery system for aided replacement valve recapture and repositioning post- deployment
US11051934B2 (en) 2018-02-28 2021-07-06 Edwards Lifesciences Corporation Prosthetic mitral valve with improved anchors and seal
WO2019169087A1 (en) 2018-02-28 2019-09-06 Edwards Lifesciences Corporation Prosthetic mitral valve with improved anchors and seal
US11389297B2 (en) 2018-04-12 2022-07-19 Edwards Lifesciences Corporation Mitral valve spacer device
US11207181B2 (en) 2018-04-18 2021-12-28 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11344415B2 (en) 2018-10-10 2022-05-31 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11278409B2 (en) 2018-10-10 2022-03-22 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11083582B2 (en) 2018-10-10 2021-08-10 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11234823B2 (en) 2018-10-10 2022-02-01 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11129717B2 (en) 2018-10-10 2021-09-28 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11766330B2 (en) 2018-10-10 2023-09-26 Edwards Lifesciences Corporation Valve repair devices for repairing a native valve of a patient
US11202710B2 (en) 2018-10-10 2021-12-21 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11147672B2 (en) 2018-10-10 2021-10-19 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11839544B2 (en) 2019-02-14 2023-12-12 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11602433B2 (en) 2019-03-25 2023-03-14 inQB8 Medical Technologies, LLC Prosthetic heart valve
WO2020198389A1 (en) * 2019-03-25 2020-10-01 Inqb8 Medical Technologies Llc Prosthetic heart valve
US11324594B2 (en) 2019-03-25 2022-05-10 inQB8 Medical Technologies, LLC Prosthetic heart valve
US11779742B2 (en) 2019-05-20 2023-10-10 Neovasc Tiara Inc. Introducer with hemostasis mechanism
WO2021025979A1 (en) 2019-08-02 2021-02-11 Edwards Lifesciences Corporation Rotary application of fibrous material to medical devices
WO2021080782A1 (en) 2019-10-23 2021-04-29 Edwards Lifesciences Corporation Systems and methods for tricuspid valve treatment
WO2021154493A1 (en) 2020-01-28 2021-08-05 Edwards Lifesciences Corporation Apparatus and methods for loading and deploying implants from delivery apparatuses
WO2021188405A1 (en) 2020-03-18 2021-09-23 Edwards Lifesciences Corporation Textiles, implantable medical devices using such textiles, and processes for making the same
WO2021194899A1 (en) 2020-03-24 2021-09-30 Edwards Lifesciences Corporation Delivery system configurations
WO2021221748A1 (en) 2020-04-28 2021-11-04 Edwards Lifesciences Corporation Silk-based electrospun materials for implant systems and devices
CN113768660A (en) * 2020-06-10 2021-12-10 先健科技(深圳)有限公司 Prosthetic heart valve and prosthetic heart valve system
US20220087814A1 (en) * 2020-09-24 2022-03-24 Cephea Valve Technologies, Inc. Controlled Expression of Expandable Heart Valve
WO2022155336A1 (en) 2021-01-14 2022-07-21 Edwards Lifesciences Corporation Implantable medical devices
US11918462B2 (en) 2021-01-25 2024-03-05 Boston Scientific Scimed, Inc. Valve replacement using moveable restraints and angled struts
US11918469B2 (en) 2021-02-05 2024-03-05 Edwards Lifesciences Corporation Native valve repair devices and procedures
WO2022174057A1 (en) 2021-02-11 2022-08-18 Edwards Lifesciences Corporation Delivery systems for replacement heart valves
WO2022174047A1 (en) 2021-02-11 2022-08-18 Edwards Lifesciences Corporation Dual-frame replacement heart valves
WO2022216793A1 (en) 2021-04-07 2022-10-13 Edwards Lifesciences Corporation Implantable medical devices
WO2022226090A1 (en) 2021-04-21 2022-10-27 Edwards Lifesciences Corporation Textiles for implantation
WO2022242093A1 (en) * 2021-05-17 2022-11-24 金仕生物科技(常熟)有限公司 Tricuspid valve frame and valve prosthesis thereof
WO2023091520A1 (en) 2021-11-19 2023-05-25 Edwards Lifesciences Corporation Heart valve repair devices
WO2023091769A1 (en) 2021-11-22 2023-05-25 Edwards Lifesciences Corporation Systems and methods for implant deployment
WO2023154250A1 (en) 2022-02-09 2023-08-17 Edwards Lifesciences Corporation Systems and methods for force reduction in delivery systems
WO2023200706A1 (en) 2022-04-15 2023-10-19 Edwards Lifesciences Corporation Methods and apparatus for removal of valve repair devices
CN116250971A (en) * 2023-05-09 2023-06-13 杭州启明医疗器械股份有限公司 Expandable sheath for transcatheter delivery system and delivery system

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US20220249225A1 (en) 2022-08-11
EP2777615A1 (en) 2014-09-17
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US20200170788A1 (en) 2020-06-04
US10583000B2 (en) 2020-03-10
US11324591B2 (en) 2022-05-10
US20180221143A1 (en) 2018-08-09

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