JPH11509094A - 統合された核酸診断装置 - Google Patents

統合された核酸診断装置

Info

Publication number
JPH11509094A
JPH11509094A JP9505261A JP50526197A JPH11509094A JP H11509094 A JPH11509094 A JP H11509094A JP 9505261 A JP9505261 A JP 9505261A JP 50526197 A JP50526197 A JP 50526197A JP H11509094 A JPH11509094 A JP H11509094A
Authority
JP
Japan
Prior art keywords
chamber
fluid
chambers
pressure
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP9505261A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11509094A5 (enExample
Inventor
シー． アンダーソン，ロルフ
ジェイ． リップシャッツ，ロバート
ピー． ラバ，リチャード
ピー．エー． フォーダー，スティーブン
Original Assignee
アフィメトリックス，インコーポレイティド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アフィメトリックス，インコーポレイティド filed Critical アフィメトリックス，インコーポレイティド
Publication of JPH11509094A publication Critical patent/JPH11509094A/ja
Publication of JPH11509094A5 publication Critical patent/JPH11509094A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/65—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being directly submitted to a pulsating movement, e.g. by means of an oscillating piston or air column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B01F31/86—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations with vibration of the receptacle or part of it
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71745—Feed mechanisms characterised by the means for feeding the components to the mixer using pneumatic pressure, overpressure, gas or air pressure in a closed receptacle or circuit system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7176—Feed mechanisms characterised by the means for feeding the components to the mixer using pumps
    • B01F35/71761—Membrane pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/718—Feed mechanisms characterised by the means for feeding the components to the mixer using vacuum, under pressure in a closed receptacle or circuit system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/44—Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/25—Mixers with loose mixing elements, e.g. loose balls in a receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP9505261A 1995-06-29 1996-06-27 統合された核酸診断装置 Ceased JPH11509094A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US70395P 1995-06-29 1995-06-29
US85995P 1995-07-03 1995-07-03
US60/000,859 1995-07-03
US60/000,703 1995-07-29
US08/589,027 US5856174A (en) 1995-06-29 1996-01-19 Integrated nucleic acid diagnostic device
US08/589,027 1996-01-19
PCT/US1996/011147 WO1997002357A1 (en) 1995-06-29 1996-06-27 Integrated nucleic acid diagnostic device

Publications (2)

Publication Number Publication Date
JPH11509094A true JPH11509094A (ja) 1999-08-17
JPH11509094A5 JPH11509094A5 (enExample) 2004-08-05

Family

ID=27356719

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9505261A Ceased JPH11509094A (ja) 1995-06-29 1996-06-27 統合された核酸診断装置

Country Status (7)

Country Link
US (7) US5856174A (enExample)
EP (2) EP0843734B1 (enExample)
JP (1) JPH11509094A (enExample)
AT (2) ATE386590T1 (enExample)
AU (1) AU6404996A (enExample)
DE (2) DE69626988T2 (enExample)
WO (1) WO1997002357A1 (enExample)

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003516762A (ja) * 1999-12-17 2003-05-20 ベーイーオー・メリュー リボ核酸を標識する方法、及びそれにより得られた標識化ｒｎａ断片
WO2003052427A1 (en) * 2001-12-14 2003-06-26 Arkray, Inc. Sample measuring device
WO2006092959A1 (ja) * 2005-03-01 2006-09-08 Rohm Co., Ltd マイクロ流路及びマイクロ流体チップ
JP2006239538A (ja) * 2005-03-02 2006-09-14 Rohm Co Ltd マイクロ流路及びマイクロチップ
JP2007171172A (ja) * 2005-12-21 2007-07-05 Samsung Electronics Co Ltd 流体のｐＨを電気化学的に調節するための微細流動装置、及び該装置の内部の流体のｐＨを電気化学的に調節する方法
JP2009139381A (ja) * 2007-12-04 2009-06-25 Headway Technologies Inc 被標識物質の捕捉・搬送装置並びに同定・計数方法および計数・選別方法
US7598064B2 (en) 2004-12-17 2009-10-06 Samsung Electronics Co., Ltd. Microfluidic device comprising electrolysis device for cell lysis and method for electrochemically lysing cells using the same
JPWO2007142061A1 (ja) * 2006-06-06 2009-10-22 コニカミノルタエムジー株式会社 マイクロチップ検査装置
US7754476B2 (en) 2004-02-13 2010-07-13 Canon Kabushiki Kaisha Biochemical reaction cartridge
JP2011516034A (ja) * 2008-02-29 2011-05-26 ノースウエスタン ユニバーシティ 生物反応促進用バリア
US7988913B2 (en) 2003-03-31 2011-08-02 Canon Kabushiki Kaisha Biochemical reaction cartridge
US8025853B2 (en) 2004-12-13 2011-09-27 Canon Kabushiki Kaisha Biochemical processing apparatus
JP2012504952A (ja) * 2008-10-10 2012-03-01 ユニバーシティー オブ ハル Ｄｎａの抽出、増幅、及び分析のためのマイクロ流体装置及び方法
US8178056B2 (en) 2004-11-02 2012-05-15 Canon Kabushiki Kaisha Biochemical reaction cartridge and biochemical treatment equipment system
US8249681B2 (en) 2005-01-31 2012-08-21 Given Imaging Ltd. Device, system and method for in vivo analysis
US8318109B2 (en) 2003-01-14 2012-11-27 Micronics, Inc. Microfluidic devices for fluid manipulation and analysis
JP2013527769A (ja) * 2010-05-06 2013-07-04 アイビス バイオサイエンシズ インコーポレイティッド 統合された試料調製システムおよび安定化酵素混合物
JP2015504352A (ja) * 2011-10-31 2015-02-12 ゼネラル・エレクトリック・カンパニイ マイクロ流体チップ及びその関連方法
JP2016518922A (ja) * 2013-04-15 2016-06-30 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 生物学的流体採取デバイスならびに生物学的流体分離および検査システム
JP2017526352A (ja) * 2014-08-05 2017-09-14 ザ チャールズ スターク ドレイパー ラボラトリー インク 流体レベリング装置を組み込む流体循環システム
US10107797B2 (en) 2008-10-03 2018-10-23 Micronics, Inc. Microfluidic apparatus and methods for performing blood typing and crossmatching
US10386377B2 (en) 2013-05-07 2019-08-20 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
JP2021502546A (ja) * 2017-11-09 2021-01-28 インターナショナル・ビジネス・マシーンズ・コーポレーションＩｎｔｅｒｎａｔｉｏｎａｌ Ｂｕｓｉｎｅｓｓ Ｍａｃｈｉｎｅｓ Ｃｏｒｐｏｒａｔｉｏｎ 検体検出のためのｐＨ制御デバイス、センサデバイス及びｐＨを制御するための方法
JP2021531975A (ja) * 2018-07-26 2021-11-25 レックス ダイアグノスティックス リミテッド 可変温度反応器、可変温度反応器のためのヒータおよび制御回路
WO2022070669A1 (ja) * 2020-09-29 2022-04-07 Nok株式会社 粒子解析装置およびその製造方法
JP2024506655A (ja) * 2021-02-13 2024-02-14 アプティテュード メディカル システムズ、インコーポレイテッド サンプルを分析するためのシステム及び方法

Families Citing this family (1614)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7040653B1 (en) * 2004-10-27 2006-05-09 Automotive Technologies International, Inc. Steering wheel assemblies for vehicles
US6905882B2 (en) 1992-05-21 2005-06-14 Biosite, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6767510B1 (en) 1992-05-21 2004-07-27 Biosite, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6156270A (en) 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US7524456B1 (en) 1992-05-21 2009-04-28 Biosite Incorporated Diagnostic devices for the controlled movement of reagents without membranes
US6309602B1 (en) 1993-11-01 2001-10-30 Nanogen, Inc. Stacked, reconfigurable system for electrophoretic transport of charged materials
US20040077074A1 (en) * 1993-11-01 2004-04-22 Nanogen, Inc. Multi-chambered analysis device
US6319472B1 (en) * 1993-11-01 2001-11-20 Nanogen, Inc. System including functionally separated regions in electrophoretic system
US6375899B1 (en) * 1993-11-01 2002-04-23 Nanogen, Inc. Electrophoretic buss for transport of charged materials in a multi-chamber system
US6129828A (en) * 1996-09-06 2000-10-10 Nanogen, Inc. Apparatus and methods for active biological sample preparation
US6638482B1 (en) * 1993-11-01 2003-10-28 Nanogen, Inc. Reconfigurable detection and analysis apparatus and method
US6287517B1 (en) * 1993-11-01 2001-09-11 Nanogen, Inc. Laminated assembly for active bioelectronic devices
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
EP0695941B1 (en) * 1994-06-08 2002-07-31 Affymetrix, Inc. Method and apparatus for packaging a chip
US6403367B1 (en) * 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
US7857957B2 (en) * 1994-07-07 2010-12-28 Gamida For Life B.V. Integrated portable biological detection system
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6654505B2 (en) 1994-10-13 2003-11-25 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
US6406848B1 (en) * 1997-05-23 2002-06-18 Lynx Therapeutics, Inc. Planar arrays of microparticle-bound polynucleotides
US5959098A (en) 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
US6454945B1 (en) 1995-06-16 2002-09-24 University Of Washington Microfabricated devices and methods
US5716852A (en) * 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US20050100946A1 (en) * 1995-06-29 2005-05-12 Affymetrix, Inc. Integrated nucleic acid diagnostic device and method for in-situ confocal microscopy
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6057149A (en) * 1995-09-15 2000-05-02 The University Of Michigan Microscale devices and reactions in microscale devices
US6911183B1 (en) * 1995-09-15 2005-06-28 The Regents Of The University Of Michigan Moving microdroplets
US5888830A (en) 1995-09-22 1999-03-30 Berlex Laboratories, Inc. Apparatus and process for multiple chemical reactions
US20020068357A1 (en) * 1995-09-28 2002-06-06 Mathies Richard A. Miniaturized integrated nucleic acid processing and analysis device and method
US5948684A (en) 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
US6541213B1 (en) 1996-03-29 2003-04-01 University Of Washington Microscale diffusion immunoassay
US7244622B2 (en) * 1996-04-03 2007-07-17 Applera Corporation Device and method for multiple analyte detection
US6825047B1 (en) * 1996-04-03 2004-11-30 Applera Corporation Device and method for multiple analyte detection
US7235406B1 (en) 1996-04-03 2007-06-26 Applera Corporation Nucleic acid analysis device
US5885470A (en) * 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US6706875B1 (en) * 1996-04-17 2004-03-16 Affyemtrix, Inc. Substrate preparation process
US6232124B1 (en) 1996-05-06 2001-05-15 Verification Technologies, Inc. Automated fingerprint methods and chemistry for product authentication and monitoring
US6054277A (en) * 1996-05-08 2000-04-25 Regents Of The University Of Minnesota Integrated microchip genetic testing system
AU754363B2 (en) * 1996-06-28 2002-11-14 Caliper Life Sciences, Inc. Microfluidic device and method
US5779868A (en) * 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
NZ333346A (en) 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
EP0909385B1 (en) * 1996-06-28 2008-09-10 Caliper Life Sciences, Inc. Method of transporting fluid samples within a microfluidic channel
US5800690A (en) * 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US6074827A (en) * 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
CA2301230A1 (en) 1996-09-20 1998-03-26 Digital Drives, Inc. Spatially addressable combinatorial chemical arrays in cd-rom format
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US6447727B1 (en) 1996-11-19 2002-09-10 Caliper Technologies Corp. Microfluidic systems
US6465257B1 (en) 1996-11-19 2002-10-15 Caliper Technologies Corp. Microfluidic systems
DE19648458C1 (de) * 1996-11-22 1998-07-09 Evotec Biosystems Gmbh Mikromechanische Ejektionspumpe zum Heraustrennen kleinster Fluidvolumina aus einem strömenden Probenfluid
DE19648695C2 (de) * 1996-11-25 1999-07-22 Abb Patent Gmbh Vorrichtung zur automatischen und kontinuierlichen Analyse von Flüssigkeitsproben
EP0956449B1 (de) * 1996-12-11 2002-05-29 Gesim Gesellschaft für Silizium-Mikrosysteme mbH Mikroejektionspumpe
ATE273381T1 (de) 1997-02-12 2004-08-15 Eugene Y Chan Verfahren zur analyse von polymeren
DE19708472C2 (de) * 1997-02-20 1999-02-18 Atotech Deutschland Gmbh Herstellverfahren für chemische Mikroreaktoren
JP2001521379A (ja) * 1997-03-28 2001-11-06 ザ パーキン−エルマー コーポレーション Ｐｃｒのための熱サイクラの改良
US5964995A (en) * 1997-04-04 1999-10-12 Caliper Technologies Corp. Methods and systems for enhanced fluid transport
US6235471B1 (en) 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
US6391622B1 (en) 1997-04-04 2002-05-21 Caliper Technologies Corp. Closed-loop biochemical analyzers
US6872527B2 (en) * 1997-04-16 2005-03-29 Xtrana, Inc. Nucleic acid archiving
AU745126B2 (en) * 1997-04-16 2002-03-14 Applied Biosystems, Llc Nucleic acid archiving
US6143496A (en) * 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US7033474B1 (en) 1997-04-25 2006-04-25 Caliper Life Sciences, Inc. Microfluidic devices incorporating improved channel geometries
KR100351531B1 (ko) * 1997-04-25 2002-09-11 캘리퍼 테크놀로지스 코포레이션 기하형상이 개선된 채널을 채용하는 미소 유체 장치
US5976336A (en) * 1997-04-25 1999-11-02 Caliper Technologies Corp. Microfluidic devices incorporating improved channel geometries
WO1998049344A1 (en) * 1997-04-28 1998-11-05 Lockheed Martin Energy Research Corporation Method and apparatus for analyzing nucleic acids
US6410275B1 (en) 1997-05-02 2002-06-25 Biomerieux, Inc. Disposable test devices for performing nucleic acid amplification reactions
IL124275A (en) * 1997-05-02 2002-03-10 Bio Merieux Vitek Inc A method to produce sequences of nucleic acids
US6429007B1 (en) 1997-05-02 2002-08-06 BIOMéRIEUX, INC. Nucleic acid amplification reaction station for disposable test devices
US6558901B1 (en) * 1997-05-02 2003-05-06 Biomerieux Vitek Nucleic acid assays
US5989499A (en) * 1997-05-02 1999-11-23 Biomerieux, Inc. Dual chamber disposable reaction vessel for amplification reactions
DE19719862A1 (de) * 1997-05-12 1998-11-19 Fraunhofer Ges Forschung Mikromembranpumpe
US6969488B2 (en) 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
US6090251A (en) 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
US5869004A (en) * 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
WO1998056956A1 (en) 1997-06-09 1998-12-17 Caliper Technologies Corporation Apparatus and methods for correcting for variable velocity in microfluidic systems
US20030013115A1 (en) * 1997-06-16 2003-01-16 Diversa Corporation, A Delaware Corporation Capillary array-based sample screening
US5882465A (en) 1997-06-18 1999-03-16 Caliper Technologies Corp. Method of manufacturing microfluidic devices
US6425972B1 (en) 1997-06-18 2002-07-30 Calipher Technologies Corp. Methods of manufacturing microfabricated substrates
GB9715101D0 (en) * 1997-07-18 1997-09-24 Environmental Sensors Ltd The production of microstructures for analysis of fluids
US6293012B1 (en) 1997-07-21 2001-09-25 Ysi Incorporated Method of making a fluid flow module
US6073482A (en) * 1997-07-21 2000-06-13 Ysi Incorporated Fluid flow module
US5932799A (en) * 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
US6431695B1 (en) 1998-06-18 2002-08-13 3M Innovative Properties Company Microstructure liquid dispenser
US6907921B2 (en) 1998-06-18 2005-06-21 3M Innovative Properties Company Microchanneled active fluid heat exchanger
US6514412B1 (en) 1998-06-18 2003-02-04 3M Innovative Properties Company Microstructured separation device
US6375871B1 (en) 1998-06-18 2002-04-23 3M Innovative Properties Company Methods of manufacturing microfluidic articles
US5876675A (en) * 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US5989402A (en) * 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
US5965410A (en) * 1997-09-02 1999-10-12 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US6016712A (en) * 1997-09-18 2000-01-25 Accumetrics Device for receiving and processing a sample
US6540895B1 (en) 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
US6833242B2 (en) * 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US6126804A (en) * 1997-09-23 2000-10-03 The Regents Of The University Of California Integrated polymerase chain reaction/electrophoresis instrument
US7214298B2 (en) * 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
US5993611A (en) * 1997-09-24 1999-11-30 Sarnoff Corporation Capacitive denaturation of nucleic acid
US6012902A (en) 1997-09-25 2000-01-11 Caliper Technologies Corp. Micropump
US5842787A (en) * 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US5958694A (en) * 1997-10-16 1999-09-28 Caliper Technologies Corp. Apparatus and methods for sequencing nucleic acids in microfluidic systems
US6111096A (en) * 1997-10-31 2000-08-29 Bbi Bioseq, Inc. Nucleic acid isolation and purification
US6174675B1 (en) 1997-11-25 2001-01-16 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US7473401B1 (en) * 1997-12-04 2009-01-06 Mds Analytical Technologies (Us) Inc. Fluidic extraction of microdissected samples
US5948227A (en) * 1997-12-17 1999-09-07 Caliper Technologies Corp. Methods and systems for performing electrophoretic molecular separations
US8071384B2 (en) 1997-12-22 2011-12-06 Roche Diagnostics Operations, Inc. Control and calibration solutions and methods for their use
US7407811B2 (en) 1997-12-22 2008-08-05 Roche Diagnostics Operations, Inc. System and method for analyte measurement using AC excitation
US7494816B2 (en) 1997-12-22 2009-02-24 Roche Diagnostic Operations, Inc. System and method for determining a temperature during analyte measurement
US7390667B2 (en) 1997-12-22 2008-06-24 Roche Diagnostics Operations, Inc. System and method for analyte measurement using AC phase angle measurements
EP1179585B1 (en) 1997-12-24 2008-07-09 Cepheid Device and method for lysis
US6857449B1 (en) 1998-01-20 2005-02-22 Caliper Life Sciences, Inc. Multi-layer microfluidic devices
US6167910B1 (en) 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
WO1999039120A1 (en) * 1998-01-29 1999-08-05 University Of Pittsburgh Thermal expansion-induced fluid control for microfluidic devices
US6210882B1 (en) 1998-01-29 2001-04-03 Mayo Foundation For Medical Education And Reseach Rapid thermocycling for sample analysis
CN1187445C (zh) * 1998-02-10 2005-02-02 东洋钢钣株式会社 用于制备固定化的dna文库或用于基因扩增的装置
US6420143B1 (en) 1998-02-13 2002-07-16 Caliper Technologies Corp. Methods and systems for performing superheated reactions in microscale fluidic systems
US6251343B1 (en) 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6100541A (en) 1998-02-24 2000-08-08 Caliper Technologies Corporation Microfluidic devices and systems incorporating integrated optical elements
US6756019B1 (en) 1998-02-24 2004-06-29 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US7497994B2 (en) 1998-02-24 2009-03-03 Khushroo Gandhi Microfluidic devices and systems incorporating cover layers
US6979424B2 (en) 1998-03-17 2005-12-27 Cepheid Integrated sample analysis device
US7188001B2 (en) * 1998-03-23 2007-03-06 Cepheid System and method for temperature control
US6391005B1 (en) * 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
WO1999052633A1 (en) * 1998-04-14 1999-10-21 Ivd Systems Test cartridge with a single inlet port
EP2316571A3 (en) 1998-05-01 2011-07-27 Gen-Probe Incorporated Automated diagnostic analyzer and method
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6979728B2 (en) * 1998-05-04 2005-12-27 Baylor College Of Medicine Articles of manufacture and methods for array based analysis of biological molecules
US6123798A (en) 1998-05-06 2000-09-26 Caliper Technologies Corp. Methods of fabricating polymeric structures incorporating microscale fluidic elements
CA2320296A1 (en) 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
WO1999064836A1 (en) 1998-06-08 1999-12-16 Caliper Technologies Corp. Microfluidic devices, systems and methods for performing integrated reactions and separations
US6274089B1 (en) 1998-06-08 2001-08-14 Caliper Technologies Corp. Microfluidic devices, systems and methods for performing integrated reactions and separations
US6761816B1 (en) * 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6540896B1 (en) 1998-08-05 2003-04-01 Caliper Technologies Corp. Open-Field serial to parallel converter
DE19836109A1 (de) * 1998-08-10 2000-03-02 Biotul Bio Instr Gmbh Vorrichtung und Verfahren zur grenzflächennahen Mischung von Proben in Biosensorsystemen
US6132685A (en) 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6107038A (en) * 1998-08-14 2000-08-22 Agilent Technologies Inc. Method of binding a plurality of chemicals on a substrate by electrophoretic self-assembly
US6186659B1 (en) * 1998-08-21 2001-02-13 Agilent Technologies Inc. Apparatus and method for mixing a film of fluid
US6572830B1 (en) 1998-10-09 2003-06-03 Motorola, Inc. Integrated multilayered microfludic devices and methods for making the same
US6591852B1 (en) 1998-10-13 2003-07-15 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
US6601613B2 (en) 1998-10-13 2003-08-05 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
US6637463B1 (en) 1998-10-13 2003-10-28 Biomicro Systems, Inc. Multi-channel microfluidic system design with balanced fluid flow distribution
KR20010089295A (ko) 1998-10-13 2001-09-29 마이클 알. 맥닐리 수동 유체 동역학에 의한 유체회로 및 유체회로내에서의방법
US6149787A (en) * 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
ATE256501T1 (de) 1998-10-16 2004-01-15 Commissariat Energie Atomique Testträger zur chemischen und/oder biochemischen analyse
US7115422B1 (en) * 1998-10-23 2006-10-03 Micron Technology, Inc. Separation apparatus including porous silicon column
US6762057B1 (en) * 1998-10-23 2004-07-13 Micron Technology, Inc. Separation apparatus including porous silicon column
US6086740A (en) 1998-10-29 2000-07-11 Caliper Technologies Corp. Multiplexed microfluidic devices and systems
US6273687B1 (en) * 1998-11-26 2001-08-14 Aisin Seiki Kabushiki Kaisha Micromachined pump apparatus
EP1144092A4 (en) * 1998-12-23 2002-10-29 Nanogen Inc Integrated portable biological detection system
US7914994B2 (en) 1998-12-24 2011-03-29 Cepheid Method for separating an analyte from a sample
US6431476B1 (en) 1999-12-21 2002-08-13 Cepheid Apparatus and method for rapid ultrasonic disruption of cells or viruses
US6261431B1 (en) * 1998-12-28 2001-07-17 Affymetrix, Inc. Process for microfabrication of an integrated PCR-CE device and products produced by the same
US6087112A (en) * 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US20030180789A1 (en) * 1998-12-30 2003-09-25 Dale Roderic M.K. Arrays with modified oligonucleotide and polynucleotide compositions
US6056269A (en) * 1999-01-15 2000-05-02 Hewlett-Packard Company Microminiature valve having silicon diaphragm
US6490030B1 (en) 1999-01-18 2002-12-03 Verification Technologies, Inc. Portable product authentication device
US6150119A (en) 1999-01-19 2000-11-21 Caliper Technologies Corp. Optimized high-throughput analytical system
US6284195B1 (en) * 1999-01-25 2001-09-04 Industrial Technology Research Institute Disposable reaction module
US20020019059A1 (en) * 1999-01-28 2002-02-14 Calvin Y.H. Chow Devices, systems and methods for time domain multiplexing of reagents
WO2000046594A1 (en) 1999-02-02 2000-08-10 Caliper Technologies Corp. Methods, devices and systems for characterizing proteins
ATE334197T1 (de) * 1999-02-19 2006-08-15 Febit Biotech Gmbh Verfahren zur herstellung von polymeren
US6632655B1 (en) * 1999-02-23 2003-10-14 Caliper Technologies Corp. Manipulation of microparticles in microfluidic systems
US7150994B2 (en) * 1999-03-03 2006-12-19 Symyx Technologies, Inc. Parallel flow process optimization reactor
US20020042140A1 (en) * 1999-03-03 2002-04-11 Alfred Hagemeyer Methods for analysis of heterogeneous catalysts in a multi-variable screening reactor
US6171850B1 (en) 1999-03-08 2001-01-09 Caliper Technologies Corp. Integrated devices and systems for performing temperature controlled reactions and analyses
AU3174600A (en) 1999-03-10 2000-09-28 Asm Scientific, Inc. A method for direct nucleic acid sequencing
AU6048199A (en) 1999-03-11 2000-09-28 Whatman, Inc. Solid medium and process for the storage and rapid purification of nucleic acid
US6148508A (en) 1999-03-12 2000-11-21 Caliper Technologies Corp. Method of making a capillary for electrokinetic transport of materials
TW496775B (en) 1999-03-15 2002-08-01 Aviva Bioscience Corp Individually addressable micro-electromagnetic unit array chips
CN1185492C (zh) 1999-03-15 2005-01-19 清华大学 可单点选通式微电磁单元阵列芯片、电磁生物芯片及应用
FR2791067B1 (fr) 1999-03-16 2003-01-31 Pasteur Institut Sequence deletees chez m.bovis bcg/m.ou m.tuberculosis, procede de detection des mycobacteries utilisant ces sequences et vaccins
DE19913451C2 (de) * 1999-03-25 2001-11-22 Gsf Forschungszentrum Umwelt Gaseinlaß zur Erzeugung eines gerichteten und gekühlten Gasstrahls
US6500323B1 (en) 1999-03-26 2002-12-31 Caliper Technologies Corp. Methods and software for designing microfluidic devices
US7244396B2 (en) * 1999-04-06 2007-07-17 Uab Research Foundation Method for preparation of microarrays for screening of crystal growth conditions
US20030022383A1 (en) * 1999-04-06 2003-01-30 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US7250305B2 (en) * 2001-07-30 2007-07-31 Uab Research Foundation Use of dye to distinguish salt and protein crystals under microcrystallization conditions
US7247490B2 (en) * 1999-04-06 2007-07-24 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US7214540B2 (en) * 1999-04-06 2007-05-08 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US6303343B1 (en) 1999-04-06 2001-10-16 Caliper Technologies Corp. Inefficient fast PCR
DE60034033T2 (de) * 1999-04-06 2007-12-06 University of Alabama, Birmingham Research Foundation, Birmingham Vorrichtung zum screening von kristallisierungsbedingungen in lösungen zur kristallzüchtung
JP4555484B2 (ja) * 1999-04-07 2010-09-29 デニス マイケル コノリー 高解像度のｄｎａ検出の方法および装置
US6322683B1 (en) 1999-04-14 2001-11-27 Caliper Technologies Corp. Alignment of multicomponent microfabricated structures
US6284465B1 (en) 1999-04-15 2001-09-04 Agilent Technologies, Inc. Apparatus, systems and method for locating nucleic acids bound to surfaces
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US7312087B2 (en) * 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6942771B1 (en) * 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US20040053290A1 (en) * 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
EP1177043A2 (en) * 1999-04-29 2002-02-06 Genome Therapeutics Corporation Device for rapid dna sample processing with integrated liquid handling, thermocycling, and purification
AU770678B2 (en) 1999-05-17 2004-02-26 Caliper Life Sciences, Inc. Focusing of microparticles in microfluidic systems
US6592821B1 (en) 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
US7056661B2 (en) * 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US8815521B2 (en) 2000-05-30 2014-08-26 Cepheid Apparatus and method for cell disruption
US6818185B1 (en) 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
US9073053B2 (en) 1999-05-28 2015-07-07 Cepheid Apparatus and method for cell disruption
EP1208189B1 (en) 1999-05-28 2004-10-06 Cepheid Device and method for analysing liquid samples
US20040200909A1 (en) * 1999-05-28 2004-10-14 Cepheid Apparatus and method for cell disruption
US6635163B1 (en) * 1999-06-01 2003-10-21 Cornell Research Foundation, Inc. Entropic trapping and sieving of molecules
AU5291600A (en) 1999-06-01 2000-12-18 Caliper Technologies Corporation Microscale assays and microfluidic devices for transporter, gradient induced, and binding activities
AU5870200A (en) * 1999-06-03 2000-12-28 Jonathan Hibbs Non-cognate hybridization system (nchs)
CN1362903A (zh) * 1999-06-08 2002-08-07 微生物系统公司 经掺杂的碳氟化合物材料的激光烧蚀及其应用
FR2795426A1 (fr) * 1999-06-22 2000-12-29 Commissariat Energie Atomique Support d'analyse biologique a amplification
FR2795518B1 (fr) * 1999-06-22 2001-12-21 Biomerieux Sa Dispositif de mise en oeuvre d'une carte d'analyse, carte d'analyse et procede les mettant en oeuvre
US6664104B2 (en) 1999-06-25 2003-12-16 Cepheid Device incorporating a microfluidic chip for separating analyte from a sample
US6200781B1 (en) * 1999-06-25 2001-03-13 Integrated Genetic Devices, Ltd. Apparatus, system and method for automated execution and analysis of biological and chemical reactions
US7144616B1 (en) * 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6899137B2 (en) * 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US8709153B2 (en) 1999-06-28 2014-04-29 California Institute Of Technology Microfludic protein crystallography techniques
US6929030B2 (en) * 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7244402B2 (en) * 2001-04-06 2007-07-17 California Institute Of Technology Microfluidic protein crystallography
US7501245B2 (en) * 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US20080277007A1 (en) * 1999-06-28 2008-11-13 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6818395B1 (en) * 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US7052545B2 (en) * 2001-04-06 2006-05-30 California Institute Of Technology High throughput screening of crystallization of materials
US8052792B2 (en) * 2001-04-06 2011-11-08 California Institute Of Technology Microfluidic protein crystallography techniques
EP1065378B1 (en) 1999-06-28 2002-04-03 California Institute of Technology Microfabricated elastomeric valve and pump systems
US8550119B2 (en) * 1999-06-28 2013-10-08 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7217321B2 (en) * 2001-04-06 2007-05-15 California Institute Of Technology Microfluidic protein crystallography techniques
US7459022B2 (en) * 2001-04-06 2008-12-02 California Institute Of Technology Microfluidic protein crystallography
US7306672B2 (en) * 2001-04-06 2007-12-11 California Institute Of Technology Microfluidic free interface diffusion techniques
US7195670B2 (en) * 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US6258593B1 (en) * 1999-06-30 2001-07-10 Agilent Technologies Inc. Apparatus for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber
US6692914B1 (en) 1999-07-02 2004-02-17 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto
HK1046381A1 (zh) * 1999-07-02 2003-01-10 Clondiag Chip Technologies Gmbh 用於复制和描述核酸的芯片矩阵装置
US6771376B2 (en) 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
PT1192448E (pt) 1999-07-05 2007-01-31 Novartis Ag Processo para a utilização de uma plataforma de sensor
DE60011429T3 (de) † 1999-07-07 2010-07-08 3M Innovative Properties Co., Saint Paul Nachweisgerät mit einer fluid-kontroll-filmschicht mit kapillarkanälen
US7223364B1 (en) 1999-07-07 2007-05-29 3M Innovative Properties Company Detection article having fluid control film
US6533914B1 (en) 1999-07-08 2003-03-18 Shaorong Liu Microfabricated injector and capillary array assembly for high-resolution and high throughput separation
US6395232B1 (en) * 1999-07-09 2002-05-28 Orchid Biosciences, Inc. Fluid delivery system for a microfluidic device using a pressure pulse
EP1813683A1 (en) * 1999-07-16 2007-08-01 Applera Corporation Method for polymerase chain reaction in a microfluidic device
US7022517B1 (en) 1999-07-16 2006-04-04 Board Of Regents, The University Of Texas System Method and apparatus for the delivery of samples to a chemical sensor array
US7079230B1 (en) 1999-07-16 2006-07-18 Sun Chemical B.V. Portable authentication device and method of authenticating products or product packaging
EP1204859B1 (en) 1999-07-16 2006-11-22 The Board Of Regents, The University Of Texas System Method and apparatus for the delivery of samples to a chemical sensor array
US6864050B2 (en) 1999-07-30 2005-03-08 Affymetrix, Inc. Single-phase amplification of nucleic acids
US7179638B2 (en) 1999-07-30 2007-02-20 Large Scale Biology Corporation Microarrays and their manufacture by slicing
US6713309B1 (en) 1999-07-30 2004-03-30 Large Scale Proteomics Corporation Microarrays and their manufacture
TW517154B (en) * 1999-08-11 2003-01-11 Asahi Chemical Ind Analyzing cartridge and liquid feed control device
US6495104B1 (en) 1999-08-19 2002-12-17 Caliper Technologies Corp. Indicator components for microfluidic systems
US6858185B1 (en) 1999-08-25 2005-02-22 Caliper Life Sciences, Inc. Dilutions in high throughput systems with a single vacuum source
US6613581B1 (en) 1999-08-26 2003-09-02 Caliper Technologies Corp. Microfluidic analytic detection assays, devices, and integrated systems
US20050118618A1 (en) * 1999-08-30 2005-06-02 Dale Roderic M. Method for detecting nucleic acid sequences
EP1080785A1 (en) * 1999-09-04 2001-03-07 F. Hoffmann-La Roche Ag System for thermocycling of fluids in cartridges
WO2001017797A1 (en) * 1999-09-10 2001-03-15 Caliper Technologies Corp. Microfabrication methods and devices
US6623945B1 (en) 1999-09-16 2003-09-23 Motorola, Inc. System and method for microwave cell lysing of small samples
US6291180B1 (en) * 1999-09-29 2001-09-18 American Registry Of Pathology Ultrasound-mediated high-speed biological reaction and tissue processing
GB9922971D0 (en) * 1999-09-29 1999-12-01 Secr Defence Reaction system
US6844151B1 (en) 1999-09-29 2005-01-18 Oligos Etc. Inc. Methods for production of arrays with modified oligonucleotide and polynucleotide compositions
AU783191B2 (en) 1999-10-08 2005-10-06 Caliper Life Sciences, Inc. Use of nernstein voltage sensitive dyes in measuring transmembrane voltage
US6743399B1 (en) * 1999-10-08 2004-06-01 Micronics, Inc. Pumpless microfluidics
EP1287162A2 (en) 1999-10-21 2003-03-05 Case Western Reserve University Gene expression profiling of inflammatory bowel disease
US7115423B1 (en) 1999-10-22 2006-10-03 Agilent Technologies, Inc. Fluidic structures within an array package
DE19952723C2 (de) * 1999-10-26 2002-10-31 Epigenomics Ag Vorrichtung und Verfahren zur Hybridisierung doppelsträngiger DNA-Proben an Oligomer-Arrays
AU1438701A (en) * 1999-10-27 2001-05-08 Caliper Technologies Corporation Pressure induced reagent introduction and electrophoretic separation
US6512580B1 (en) 1999-10-27 2003-01-28 Verification Technologies, Inc. Method and apparatus for portable product authentication
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
US6867851B2 (en) * 1999-11-04 2005-03-15 Regents Of The University Of Minnesota Scanning of biological samples
US6784982B1 (en) 1999-11-04 2004-08-31 Regents Of The University Of Minnesota Direct mapping of DNA chips to detector arrays
US6406604B1 (en) * 1999-11-08 2002-06-18 Norberto A. Guzman Multi-dimensional electrophoresis apparatus
US7329388B2 (en) * 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
US6692952B1 (en) * 1999-11-10 2004-02-17 Massachusetts Institute Of Technology Cell analysis and sorting apparatus for manipulation of cells
US6875619B2 (en) * 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US6589778B1 (en) 1999-12-15 2003-07-08 Amersham Biosciences Ab Method and apparatus for performing biological reactions on a substrate surface
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US6569674B1 (en) * 1999-12-15 2003-05-27 Amersham Biosciences Ab Method and apparatus for performing biological reactions on a substrate surface
US6642046B1 (en) 1999-12-09 2003-11-04 Motorola, Inc. Method and apparatus for performing biological reactions on a substrate surface
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
CA2290731A1 (en) * 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
CA2392753A1 (en) 1999-12-10 2001-06-14 Invitrogen Corporation Use of multiple recombination sites with unique specificity in recombinational cloning
US20020119079A1 (en) * 1999-12-10 2002-08-29 Norbert Breuer Chemical microreactor and microreactor made by process
EP1242819A2 (en) * 1999-12-15 2002-09-25 Motorola, Inc. Apparatus for performing biological reactions
US6878517B1 (en) * 1999-12-15 2005-04-12 Congra Grocery Products Company Multispecies food testing and characterization organoleptic properties
US20030091477A1 (en) * 1999-12-22 2003-05-15 Paul Eric A. Flow-thru chip cartridge, chip holder, system & method thereof
US6612737B1 (en) * 1999-12-29 2003-09-02 Affymetrix, Inc. System and method for self-calibrating measurement
AU2282801A (en) 1999-12-29 2001-07-09 Mergen Ltd. Methods for amplifying and detecting multiple polynucleotides on a solid phase support
FR2803225B1 (fr) * 1999-12-29 2002-06-14 Biomerieux Sa Appareil d'analyse a compartiment reactionnel a geometrie variable, procede de mixage et de guidage de liquides
DE60038127T2 (de) 2000-01-06 2009-03-05 Caliper Life Sciences, Inc., Mountain View Methoden und syteme zur überwachung intrazellulärer bindereaktionen
US6468761B2 (en) 2000-01-07 2002-10-22 Caliper Technologies, Corp. Microfluidic in-line labeling method for continuous-flow protease inhibition analysis
EP1276900A2 (en) * 2000-01-11 2003-01-22 Maxygen, Inc. Integrated systems and methods for diversity generation and screening
US7037416B2 (en) 2000-01-14 2006-05-02 Caliper Life Sciences, Inc. Method for monitoring flow rate using fluorescent markers
US6587579B1 (en) * 2000-01-26 2003-07-01 Agilent Technologies Inc. Feature quality in array fabrication
US6458526B1 (en) 2000-01-28 2002-10-01 Agilent Technologies, Inc. Method and apparatus to inhibit bubble formation in a fluid
WO2001055454A1 (en) * 2000-01-28 2001-08-02 Althea Technologies, Inc. Methods for analysis of gene expression
CA2401782A1 (en) * 2000-01-31 2001-08-02 John T. Mcdevitt Portable sensor array system
EP1289646A2 (de) * 2000-02-03 2003-03-12 Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts Verfahren und vorrichtung zur synthese und analyse von trägergebundenen arrays von oligomeren, insbesondere von primerpaaren für die pcr, sowie träger mit oligomeren
DE60032113T2 (de) * 2000-02-11 2007-06-28 Stmicroelectronics S.R.L., Agrate Brianza Integrierte Vorrichtung zur mikrofluidischen Temperaturregelung und dessen Herstellungsverfahren
DE10006214A1 (de) * 2000-02-11 2001-08-16 Roche Diagnostics Gmbh System zur einfachen Nukleinsäureanalytik
US20030017467A1 (en) * 2000-02-18 2003-01-23 Aclara Biosciences, Inc. Multiple-site sample-handling apparatus and method
AU2001249071B2 (en) 2000-02-23 2005-09-08 Caliper Life Sciences, Inc. Multi-reservoir pressure control system
EP1898210A3 (en) * 2000-02-23 2008-06-25 Caliper Life Sciences, Inc. Multi-reservoir pressure control system
US7040144B2 (en) 2000-02-23 2006-05-09 Caliper Life Sciences, Inc. Microfluidic viscometer
US6681616B2 (en) 2000-02-23 2004-01-27 Caliper Technologies Corp. Microfluidic viscometer
US7452713B2 (en) * 2000-02-29 2008-11-18 Stmicroelectronics S.R.L. Process for manufacturing a microfluidic device with buried channels
US7230315B2 (en) * 2000-02-29 2007-06-12 Stmicroelectronics S.R.L. Integrated chemical microreactor with large area channels and manufacturing process thereof
US7732192B2 (en) * 2000-02-29 2010-06-08 Stmicroelectronics S.R.L. Integrated chemical microreactor with large area channels and manufacturing process thereof
WO2001067369A2 (en) * 2000-03-03 2001-09-13 California Institute Of Technology Combinatorial array for nucleic acid analysis
FR2806009B1 (fr) * 2000-03-07 2002-05-31 Bio Merieux Procede de mise en oeuvre d'une carte d'analyse
DE60108482T2 (de) 2000-03-07 2006-02-16 Symyx Technologies, Inc., Santa Clara Prozessoptimierungsreaktor mit parallelem durchfluss
US20010035351A1 (en) * 2000-03-10 2001-11-01 Simpson Peter C. Cross channel device for serial sample injection
US7485454B1 (en) * 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
JP3871846B2 (ja) * 2000-03-10 2007-01-24 日立ソフトウエアエンジニアリング株式会社 ハイブリダイゼーション反応検出方法及び検出装置
US20010031495A1 (en) * 2000-03-13 2001-10-18 Hideji Tajima Integrated support, integrated minute vessels and permeable membrane and method of making and using same
US20020012971A1 (en) * 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
US6376191B1 (en) 2000-03-22 2002-04-23 Mergen, Ltd. Microarray-based analysis of polynucleotide sequence variations
US6358387B1 (en) * 2000-03-27 2002-03-19 Caliper Technologies Corporation Ultra high throughput microfluidic analytical systems and methods
US6884578B2 (en) 2000-03-31 2005-04-26 Affymetrix, Inc. Genes differentially expressed in secretory versus proliferative endometrium
US7867763B2 (en) * 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US20050118073A1 (en) * 2003-11-26 2005-06-02 Fluidigm Corporation Devices and methods for holding microfluidic devices
WO2001077641A1 (en) * 2000-04-06 2001-10-18 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6290909B1 (en) * 2000-04-13 2001-09-18 Sandia Corporation Sample injector for high pressure liquid chromatography
US6561208B1 (en) 2000-04-14 2003-05-13 Nanostream, Inc. Fluidic impedances in microfluidic system
US6481453B1 (en) 2000-04-14 2002-11-19 Nanostream, Inc. Microfluidic branch metering systems and methods
US6733645B1 (en) 2000-04-18 2004-05-11 Caliper Technologies Corp. Total analyte quantitation
US20030112423A1 (en) * 2000-04-24 2003-06-19 Rakesh Vig On-line verification of an authentication mark applied to products or product packaging
US20040000787A1 (en) * 2000-04-24 2004-01-01 Rakesh Vig Authentication mark for a product or product package
JP2003530894A (ja) * 2000-04-25 2003-10-21 アフィメトリックス インコーポレイテッド 選択的にスプライシングされた遺伝子の発現をモニターするための方法
EP1279020B1 (en) * 2000-04-26 2016-03-16 Life Technologies Corporation Laser capture microdissection (lcm) extraction device and device carrier and method for post-lcm fluid processing
EP1283909A4 (en) * 2000-05-04 2006-06-07 Univ Yale HIGH DENSITY PROTEIN ARRAYS FOR SCREENING PROTEIN ACTIVITY
CA2406718A1 (en) 2000-05-11 2001-11-15 Caliper Technologies Corp. Microfluidic devices and methods to regulate hydrodynamic and electrical resistance utilizing bulk viscosity enhancers
WO2001088195A1 (en) 2000-05-12 2001-11-22 Caliper Technologies Corp. Detection of nucleic acid hybridization by fluorescence polarization
AU2001259770A1 (en) 2000-05-15 2001-11-26 Biomicro Systems, Inc. Air flow regulation in microfluidic circuits for pressure control and gaseous exchange
WO2001089696A2 (en) * 2000-05-24 2001-11-29 Micronics, Inc. Microfluidic concentration gradient loop
US7700359B2 (en) 2000-06-02 2010-04-20 Novartis Vaccines And Diagnostics, Inc. Gene products differentially expressed in cancerous cells
WO2003057926A1 (en) 2002-01-08 2003-07-17 Chiron Corporation Gene products differentially expressed in cancerous breast cells and their methods of use
US7351376B1 (en) * 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
EP1161985B1 (en) * 2000-06-05 2005-10-26 STMicroelectronics S.r.l. Process for manufacturing integrated chemical microreactors of semiconductor material, and integrated microreactor
US6875247B2 (en) * 2000-06-06 2005-04-05 Battelle Memorial Institute Conditions for fluid separations in microchannels, capillary-driven fluid separations, and laminated devices capable of separating fluids
US6455007B1 (en) * 2000-06-13 2002-09-24 Symyx Technologies, Inc. Apparatus and method for testing compositions in contact with a porous medium
EP1164201A1 (en) * 2000-06-14 2001-12-19 Facultés Universitaires Notre-Dame de la Paix Reverse detection for identification and/or quantification of nucleotide target sequences on biochips
ES2305087T3 (es) 2000-06-15 2008-11-01 Novartis Vaccines And Diagnostics, Inc. Polinucleotidos relacionados con el cancer de colon.
AU2001269929B2 (en) * 2000-06-19 2005-11-03 Caliper Life Sciences, Inc. Methods and devices for enhancing bonded substrate yields and regulating temperature
WO2002000343A2 (en) * 2000-06-27 2002-01-03 Fluidigm Corporation A microfluidic design automation method and system
AU2001259033A1 (en) 2000-06-30 2002-01-14 Verification Technologies, Inc. Copy-protected optical media and method of manufacture thereof
US7486790B1 (en) 2000-06-30 2009-02-03 Verification Technologies, Inc. Method and apparatus for controlling access to storage media
US6638593B2 (en) 2000-06-30 2003-10-28 Verification Technologies, Inc. Copy-protected optical media and method of manufacture thereof
US7124944B2 (en) * 2000-06-30 2006-10-24 Verification Technologies, Inc. Product packaging including digital data
JP2004513619A (ja) * 2000-07-07 2004-05-13 ヴィジゲン　バイオテクノロジーズ　インコーポレイテッド リアルタイム配列決定
US20070172866A1 (en) * 2000-07-07 2007-07-26 Susan Hardin Methods for sequence determination using depolymerizing agent
EP1573416A4 (en) * 2000-07-07 2010-01-27 Fenwal Inc MEDICAL SYSTEM, METHOD AND DEVICE USING MEMS
US7193711B2 (en) * 2000-07-11 2007-03-20 Maven Technologies, Llc Imaging method and apparatus
US7023547B2 (en) 2000-07-11 2006-04-04 Maven Technologies, Llc Apparatus including a biochip for imaging of biological samples and method
US7518724B2 (en) * 2000-07-11 2009-04-14 Maven Technologies Image acquisition, processing, and display
US7126688B2 (en) * 2000-07-11 2006-10-24 Maven Technologies, Llc Microarray scanning
US6833920B2 (en) 2000-07-11 2004-12-21 Maven Technologies Llc Apparatus and method for imaging
US6594011B1 (en) 2000-07-11 2003-07-15 Maven Technologies, Llc Imaging apparatus and method
US20070119711A1 (en) * 2000-08-02 2007-05-31 Caliper Life Sciences, Inc. High throughput separations based analysis systems and methods
JP2004505275A (ja) * 2000-08-02 2004-02-19 カリパー・テクノロジーズ・コープ． 高スループット分離に基づく分析システム
US7660415B2 (en) * 2000-08-03 2010-02-09 Selinfreund Richard H Method and apparatus for controlling access to storage media
CA2415055A1 (en) 2000-08-03 2002-02-14 Caliper Technologies Corporation Methods and devices for high throughput fluid delivery
AU8306901A (en) * 2000-08-04 2002-02-18 Caliper Techn Corp Control of operation conditions within fluidic systems
US20020142618A1 (en) * 2000-08-04 2002-10-03 Caliper Technologies Corp. Control of operation conditions within fluidic systems
US6615856B2 (en) 2000-08-04 2003-09-09 Biomicro Systems, Inc. Remote valving for microfluidic flow control
US6890093B2 (en) * 2000-08-07 2005-05-10 Nanostream, Inc. Multi-stream microfludic mixers
AU2001281076A1 (en) * 2000-08-07 2002-02-18 Nanostream, Inc. Fluidic mixer in microfluidic system
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
EP2157183A1 (en) 2000-08-25 2010-02-24 BASF Plant Science GmbH Plant polynucleotides encoding prenyl proteases
US6374684B1 (en) 2000-08-25 2002-04-23 Cepheid Fluid control and processing system
US8048386B2 (en) * 2002-02-25 2011-11-01 Cepheid Fluid processing and control
FR2813207B1 (fr) * 2000-08-28 2002-10-11 Bio Merieux Carte reactionnelle et utilisation d'une telle carte
US7108969B1 (en) 2000-09-08 2006-09-19 Affymetrix, Inc. Methods for detecting and diagnosing oral cancer
WO2002023167A1 (en) * 2000-09-11 2002-03-21 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Fluidics system
JP4949600B2 (ja) 2000-09-14 2012-06-13 カリパー・ライフ・サイエンシズ・インク． 温度介在反応を行うためのマイクロ流体装置及び方法
GB2368809B (en) * 2000-09-15 2004-09-29 Norchip As Microfabricated reaction chamber system
AU2001290879A1 (en) 2000-09-15 2002-03-26 California Institute Of Technology Microfabricated crossflow devices and methods
EP1350100A2 (en) 2000-09-26 2003-10-08 Health Research, Incorporated Analysis of hiv-1 coreceptor use in the clinical care of hiv-1-infected patients
EP1193214B1 (en) * 2000-09-27 2007-01-03 STMicroelectronics S.r.l. Integrated chemical microreactor, thermally insulated from detection electrodes, and manufacturing method therefor
CN100495030C (zh) * 2000-09-30 2009-06-03 清华大学 多力操纵装置及其应用
US7097809B2 (en) * 2000-10-03 2006-08-29 California Institute Of Technology Combinatorial synthesis system
US7678547B2 (en) * 2000-10-03 2010-03-16 California Institute Of Technology Velocity independent analyte characterization
EP1322936A2 (en) * 2000-10-03 2003-07-02 California Institute Of Technology Microfluidic devices and methods of use
US6623860B2 (en) 2000-10-10 2003-09-23 Aclara Biosciences, Inc. Multilevel flow structures
EP1336097A4 (en) * 2000-10-13 2006-02-01 Fluidigm Corp SAMPLE INJECTION SYSTEM BASED ON A MICROFLUIDIC EQUIPMENT FOR ANALYTICAL EQUIPMENT
EP1203945B1 (en) * 2000-10-26 2006-12-20 Agilent Technologies, Inc. (a Delaware corporation) Microarray
US6644944B2 (en) 2000-11-06 2003-11-11 Nanostream, Inc. Uni-directional flow microfluidic components
US7232109B2 (en) * 2000-11-06 2007-06-19 California Institute Of Technology Electrostatic valves for microfluidic devices
US20090118139A1 (en) 2000-11-07 2009-05-07 Caliper Life Sciences, Inc. Microfluidic method and system for enzyme inhibition activity screening
GB0027300D0 (en) * 2000-11-08 2000-12-27 Hybaid Ltd Chip hybridisation unit
US6937323B2 (en) * 2000-11-08 2005-08-30 Burstein Technologies, Inc. Interactive system for analyzing biological samples and processing related information and the use thereof
US20020150887A1 (en) * 2000-11-09 2002-10-17 National Institute Of Advanced Industrial Science And Technology Methods and nucleic acid probes for molecular genetic analysis of polluted environments and environmental samples
ATE441110T1 (de) * 2000-11-09 2009-09-15 Sicel Technologies Inc In-vivo detektion von biomolekülekonzentrationen mittels fluoreszenzmarker
US6653124B1 (en) * 2000-11-10 2003-11-25 Cytoplex Biosciences Inc. Array-based microenvironment for cell culturing, cell monitoring and drug-target validation
US8900811B2 (en) 2000-11-16 2014-12-02 Caliper Life Sciences, Inc. Method and apparatus for generating thermal melting curves in a microfluidic device
AU2002230524A1 (en) 2000-11-16 2002-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
EP1345698A4 (en) * 2000-11-16 2006-05-17 Fluidigm Corp MICROFLUID DEVICES FOR THE INTRODUCTION AND DISPOSAL OF FLUIDS FROM MICROFLUID SYSTEMS
US7087203B2 (en) * 2000-11-17 2006-08-08 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-disc
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US6521188B1 (en) * 2000-11-22 2003-02-18 Industrial Technology Research Institute Microfluidic actuator
GB0028647D0 (en) * 2000-11-24 2001-01-10 Nextgen Sciences Ltd Apparatus for chemical assays
WO2002044425A2 (en) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
JP2004535765A (ja) 2000-12-07 2004-12-02 カイロン コーポレイション 前立腺癌においてアップレギュレートされた内因性レトロウイルス
US6995845B2 (en) * 2000-12-08 2006-02-07 Burstein Technologies, Inc. Methods for detecting analytes using optical discs and optical disc readers
JP2002236131A (ja) * 2000-12-08 2002-08-23 Minolta Co Ltd マイクロチップ
US6760298B2 (en) * 2000-12-08 2004-07-06 Nagaoka & Co., Ltd. Multiple data layer optical discs for detecting analytes
US20020072111A1 (en) * 2000-12-13 2002-06-13 Clarkin James P. Drawn microchannel array devices and method of analysis using same
US20020123134A1 (en) * 2000-12-26 2002-09-05 Mingxian Huang Active and biocompatible platforms prepared by polymerization of surface coating films
ES2232407T3 (es) * 2000-12-28 2005-06-01 F. Hoffmann-La Roche Ag Metodo para el procesado de una muestra de acido nucleico mediante la oscilacion de un segmento de una pared de un cartucho, un sistema y un cartucho para realizar dicho metodo.
AU2002246978A1 (en) * 2001-01-10 2002-07-24 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface
US20020108860A1 (en) * 2001-01-15 2002-08-15 Staats Sau Lan Tang Fabrication of polymeric microfluidic devices
JP4505776B2 (ja) * 2001-01-19 2010-07-21 凸版印刷株式会社 遺伝子検出システム、これを備えた遺伝子検出装置、検出方法、並びに遺伝子検出用チップ
US6878755B2 (en) * 2001-01-22 2005-04-12 Microgen Systems, Inc. Automated microfabrication-based biodetector
US20020098122A1 (en) * 2001-01-22 2002-07-25 Angad Singh Active disposable microfluidic system with externally actuated micropump
WO2002060754A1 (en) 2001-01-29 2002-08-08 Caliper Technologies Corp. Non-mechanical valves for fluidic systems
US20020197622A1 (en) * 2001-01-31 2002-12-26 Mcdevitt John T. Method and apparatus for the confinement of materials in a micromachined chemical sensor array
AU2002255515A1 (en) * 2001-02-05 2002-08-19 Board Of Regents, The University Of Texas System The use of mesoscale self-assembly and recognition to effect delivery of sensing reagent for arrayed sensors
AU2002250032B2 (en) 2001-02-09 2008-06-05 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
US7670559B2 (en) 2001-02-15 2010-03-02 Caliper Life Sciences, Inc. Microfluidic systems with enhanced detection systems
US6720148B1 (en) 2001-02-22 2004-04-13 Caliper Life Sciences, Inc. Methods and systems for identifying nucleotides by primer extension
US7666588B2 (en) * 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US20030027135A1 (en) * 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US7718354B2 (en) 2001-03-02 2010-05-18 Ibis Biosciences, Inc. Methods for rapid identification of pathogens in humans and animals
US7867776B2 (en) 2001-03-02 2011-01-11 Caliper Life Sciences, Inc. Priming module for microfluidic chips
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US20040121313A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in organs for transplantation
US20050196785A1 (en) * 2001-03-05 2005-09-08 California Institute Of Technology Combinational array for nucleic acid analysis
US7244232B2 (en) * 2001-03-07 2007-07-17 Biomed Solutions, Llc Process for identifying cancerous and/or metastatic cells of a living organism
US20030060695A1 (en) * 2001-03-07 2003-03-27 Connelly Patrick R. Implantable artificial organ devices
US7118917B2 (en) * 2001-03-07 2006-10-10 Symyx Technologies, Inc. Parallel flow reactor having improved thermal control
US7150999B1 (en) 2001-03-09 2006-12-19 Califer Life Sciences, Inc. Process for filling microfluidic channels
US7223363B2 (en) * 2001-03-09 2007-05-29 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
CA2440754A1 (en) * 2001-03-12 2002-09-19 Stephen Quake Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
US7316769B2 (en) * 2001-03-19 2008-01-08 Cornell Research Foundation, Inc. Length-dependent recoil separation of long molecules
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US7192557B2 (en) * 2001-03-28 2007-03-20 Handylab, Inc. Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
US7270786B2 (en) 2001-03-28 2007-09-18 Handylab, Inc. Methods and systems for processing microfluidic samples of particle containing fluids
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US6575188B2 (en) 2001-07-26 2003-06-10 Handylab, Inc. Methods and systems for fluid control in microfluidic devices
US7323140B2 (en) * 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
JP2004535273A (ja) * 2001-04-04 2004-11-25 アラダイアル， インコーポレイテッド 液体を分配するためのシステムおよび方法
US7670429B2 (en) 2001-04-05 2010-03-02 The California Institute Of Technology High throughput screening of crystallization of materials
WO2002081729A2 (en) * 2001-04-06 2002-10-17 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
ATE500051T1 (de) 2001-04-06 2011-03-15 Fluidigm Corp Polymeroberflächenmodifikation
US20020164816A1 (en) * 2001-04-06 2002-11-07 California Institute Of Technology Microfluidic sample separation device
US6752922B2 (en) * 2001-04-06 2004-06-22 Fluidigm Corporation Microfluidic chromatography
US20040132166A1 (en) * 2001-04-10 2004-07-08 Bioprocessors Corp. Determination and/or control of reactor environmental conditions
US20050032204A1 (en) * 2001-04-10 2005-02-10 Bioprocessors Corp. Microreactor architecture and methods
US20040058407A1 (en) * 2001-04-10 2004-03-25 Miller Scott E. Reactor systems having a light-interacting component
CA2440785A1 (en) * 2001-04-10 2002-10-24 Bioprocessors Corporation Microfermentor device and cell based screening method
US20040058437A1 (en) * 2001-04-10 2004-03-25 Rodgers Seth T. Materials and reactor systems having humidity and gas control
US6418968B1 (en) 2001-04-20 2002-07-16 Nanostream, Inc. Porous microfluidic valves
KR100438821B1 (ko) * 2001-04-23 2004-07-05 삼성전자주식회사 멀티채널 ｐｃｒ과 전기영동을 이용한 소형 유전자 분석장치
US6727479B2 (en) * 2001-04-23 2004-04-27 Stmicroelectronics S.R.L. Integrated device based upon semiconductor technology, in particular chemical microreactor
US6645737B2 (en) * 2001-04-24 2003-11-11 Dade Microscan Inc. Method for maintaining test accuracy within a microbiological test array
GB0110476D0 (en) 2001-04-30 2001-06-20 Secr Defence Reagent delivery system
WO2004010099A2 (en) * 2001-05-16 2004-01-29 Burstein Technologies, Inc. Variable sampling for rendering pixelization of analysis results in optical bio-disc assembly
US20050009101A1 (en) * 2001-05-17 2005-01-13 Motorola, Inc. Microfluidic devices comprising biochannels
WO2002095002A2 (en) 2001-05-22 2002-11-28 University Of Chicago N4 virion single-stranded dna dependent rna polymerase
US7723123B1 (en) 2001-06-05 2010-05-25 Caliper Life Sciences, Inc. Western blot by incorporating an affinity purification zone
US7294478B1 (en) 2001-06-06 2007-11-13 Rosetta Inpharmatics Llc Microarray reaction cartridge
US20030009294A1 (en) * 2001-06-07 2003-01-09 Jill Cheng Integrated system for gene expression analysis
US6919046B2 (en) * 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
US20020186263A1 (en) * 2001-06-07 2002-12-12 Nanostream, Inc. Microfluidic fraction collectors
US7318912B2 (en) * 2001-06-07 2008-01-15 Nanostream, Inc. Microfluidic systems and methods for combining discrete fluid volumes
US6729352B2 (en) 2001-06-07 2004-05-04 Nanostream, Inc. Microfluidic synthesis devices and methods
US6811695B2 (en) * 2001-06-07 2004-11-02 Nanostream, Inc. Microfluidic filter
US6880576B2 (en) * 2001-06-07 2005-04-19 Nanostream, Inc. Microfluidic devices for methods development
US20020187564A1 (en) * 2001-06-08 2002-12-12 Caliper Technologies Corp. Microfluidic library analysis
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7041068B2 (en) * 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
AU2002348683A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US20030165895A1 (en) * 2001-06-12 2003-09-04 Bogdan Czerniak Methods of detecting, diagnosing and treating cancer and identifying neoplastic progression
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
EP1404233B1 (en) * 2001-06-12 2009-12-02 Pelikan Technologies Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
CA2448790C (en) * 2001-06-12 2010-09-07 Pelikan Technologies, Inc. Electric lancet actuator
US9226699B2 (en) * 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US6977163B1 (en) 2001-06-13 2005-12-20 Caliper Life Sciences, Inc. Methods and systems for performing multiple reactions by interfacial mixing
US20030015425A1 (en) * 2001-06-20 2003-01-23 Coventor Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US7211442B2 (en) * 2001-06-20 2007-05-01 Cytonome, Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US7179423B2 (en) * 2001-06-20 2007-02-20 Cytonome, Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US7217510B2 (en) * 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US8073627B2 (en) * 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
US20050149304A1 (en) * 2001-06-27 2005-07-07 Fluidigm Corporation Object oriented microfluidic design method and system
US20030026705A1 (en) * 2001-06-27 2003-02-06 Tosoh Corporation Method for transporting liquid, and microreactor
US6662091B2 (en) * 2001-06-29 2003-12-09 Battelle Memorial Institute Diagnostics/prognostics using wireless links
WO2003004975A1 (en) 2001-07-02 2003-01-16 Battelle Memorial Institute Intelligent microsensor module
US6485918B1 (en) 2001-07-02 2002-11-26 Packard Bioscience Corporation Method and apparatus for incubation of a liquid reagent and target spots on a microarray substrate
US7077152B2 (en) * 2001-07-07 2006-07-18 Nanostream, Inc. Microfluidic metering systems and methods
US7668697B2 (en) * 2006-02-06 2010-02-23 Andrei Volkov Method for analyzing dynamic detectable events at the single molecule level
EP1277438A1 (en) * 2001-07-10 2003-01-22 Agilent Technologies, Inc. (a Delaware corporation) System for point of care diagnosis and/or analysis
US6825127B2 (en) 2001-07-24 2004-11-30 Zarlink Semiconductor Inc. Micro-fluidic devices
US20030064507A1 (en) * 2001-07-26 2003-04-03 Sean Gallagher System and methods for mixing within a microfluidic device
EP3427834A1 (en) * 2001-07-26 2019-01-16 Handylab, Inc. Methods and systems for microfluidic processing
US20060062696A1 (en) 2001-07-27 2006-03-23 Caliper Life Sciences, Inc. Optimized high throughput analytical systems
US7060171B1 (en) 2001-07-31 2006-06-13 Caliper Life Sciences, Inc. Methods and systems for reducing background signal in assays
CA2457391A1 (en) * 2001-08-06 2003-02-20 Vanderbilt University Device and methods for detecting the response of a plurality of cells to at least one analyte of interest
WO2003016547A2 (en) * 2001-08-13 2003-02-27 Vanderbilt University Distribution of solutions across a surface
AU2002335656A1 (en) * 2001-08-23 2003-03-10 Aclara Biosciences, Inc. Multiple-site sample-handling apparatus and method
US6995841B2 (en) 2001-08-28 2006-02-07 Rice University Pulsed-multiline excitation for color-blind fluorescence detection
US7075162B2 (en) * 2001-08-30 2006-07-11 Fluidigm Corporation Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes
US20050032060A1 (en) * 2001-08-31 2005-02-10 Shishir Shah Arrays comprising pre-labeled biological molecules and methods for making and using these arrays
FR2829948B1 (fr) * 2001-09-21 2004-07-09 Commissariat Energie Atomique Procede de deplacement d'un fluide d'interet dans un capillaire et microsysteme fluidique
US20030059823A1 (en) * 2001-09-21 2003-03-27 Juki Corporation Hybridization apparatus and method for detecting nucleic acid in sample using the same
US20030108664A1 (en) * 2001-10-05 2003-06-12 Kodas Toivo T. Methods and compositions for the formation of recessed electrical features on a substrate
DE10149684B4 (de) * 2001-10-09 2005-02-17 Clondiag Chip Technologies Gmbh Vorrichtung zur Halterung eines Substanzbibliothekenträgers
WO2003031066A1 (en) 2001-10-11 2003-04-17 California Institute Of Technology Devices utilizing self-assembled gel and method of manufacture
AU2002367886B8 (en) 2001-10-12 2008-08-14 Perkinelmer Las, Inc. Compilations of nucleic acids and arrays and methods of using them
US20030087289A1 (en) * 2001-10-12 2003-05-08 Harry Zuzan Image analysis of high-density synthetic DNA microarrays
AU2002334772A1 (en) * 2001-10-12 2003-04-28 Duke University Methods for image analysis of high-density synthetic dna microarrays
US7439346B2 (en) * 2001-10-12 2008-10-21 Perkinelmer Las Inc. Nucleic acids arrays and methods of use therefor
US20030073089A1 (en) * 2001-10-16 2003-04-17 Mauze Ganapati R. Companion cartridge for disposable diagnostic sensing platforms
US20060134683A1 (en) * 2001-10-23 2006-06-22 Michael Sogard Methods and devices for hybridization and binding assays using thermophoresis
US7244611B2 (en) * 2001-10-23 2007-07-17 Nikon Research Corporation Of America Methods and devices for hybridization and binding assays using thermophoresis
US20030138969A1 (en) * 2002-01-24 2003-07-24 Jakobsen Mogens Havsteen Closed substrate platforms suitable for analysis of biomolecules
US8440093B1 (en) 2001-10-26 2013-05-14 Fuidigm Corporation Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels
US20030086333A1 (en) * 2001-11-05 2003-05-08 Constantinos Tsouris Electrohydrodynamic mixing on microfabricated devices
US20030175947A1 (en) * 2001-11-05 2003-09-18 Liu Robin Hui Enhanced mixing in microfluidic devices
EP1451373A4 (en) * 2001-11-06 2005-01-19 Integrated Nano Tech Llc SYSTEM FOR THE DETECTION OF BIOLOGICAL MATERIALS IN A SAMPLE
US20040028559A1 (en) * 2001-11-06 2004-02-12 Peter Schuck Sample delivery system with laminar mixing for microvolume biosensing
KR100438828B1 (ko) * 2001-11-08 2004-07-05 삼성전자주식회사 칩 상의 전기적 미세 검출기
RU2316591C2 (ru) 2001-11-09 2008-02-10 Джорджтаун Юниверсити Новые изоформы ингибитора роста васкулярных эндотелиальных клеток
KR100442836B1 (ko) * 2001-11-10 2004-08-02 삼성전자주식회사 생화학 유체를 온도가 다른 폐쇄된 챔버 구간을 따라 회전이동시키는 폐쇄 유체 회로 시스템
US7247274B1 (en) 2001-11-13 2007-07-24 Caliper Technologies Corp. Prevention of precipitate blockage in microfluidic channels
US7069952B1 (en) 2001-11-14 2006-07-04 Caliper Life Sciences, Inc. Microfluidic devices and methods of their manufacture
US20030098271A1 (en) * 2001-11-26 2003-05-29 Ralph Somack Capsule and tray systems for combined sample collection, archiving, purification, and PCR
US7691333B2 (en) * 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
AU2002351187A1 (en) * 2001-11-30 2003-06-17 Fluidigm Corporation Microfluidic device and methods of using same
EP1317960A1 (en) * 2001-12-06 2003-06-11 PamGene B.V. System and method for analyzing a blood sample and disposable cartridge for use in this system or method
US6848462B2 (en) * 2001-12-06 2005-02-01 Nanostream, Inc. Adhesiveless microfluidic device fabrication
JP2003248008A (ja) * 2001-12-18 2003-09-05 Inst Of Physical & Chemical Res 反応液の攪拌方法
US7347976B2 (en) * 2001-12-20 2008-03-25 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using a hydrophilic solid support in a hydrophobic matrix
KR100408871B1 (ko) * 2001-12-20 2003-12-11 삼성전자주식회사 바이오칩 상에서 탄소나노튜브를 이용한 시료의 분리 또는여과 방법
US6739576B2 (en) 2001-12-20 2004-05-25 Nanostream, Inc. Microfluidic flow control device with floating element
US7192560B2 (en) * 2001-12-20 2007-03-20 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using anion exchange
US7258839B2 (en) * 2001-12-21 2007-08-21 Cytonome, Inc. Temperature controlled microfabricated two-pin liquid sample dispensing system
US6889468B2 (en) * 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
GB2383546B (en) * 2001-12-28 2006-03-01 Norchip As Fluid manipulation in a microfabricated reaction chamber system
WO2003060157A2 (en) * 2001-12-28 2003-07-24 Norchip As Fluid manipulation in a microfabricated reaction chamber system
US6877892B2 (en) * 2002-01-11 2005-04-12 Nanostream, Inc. Multi-stream microfluidic aperture mixers
DE10201463B4 (de) 2002-01-16 2005-07-21 Clondiag Chip Technologies Gmbh Reaktionsgefäß zur Durchführung von Array-Verfahren
FR2835058B1 (fr) * 2002-01-21 2004-03-12 Centre Nat Rech Scient Procede de detection d'au moins un parametre caracteristique de molecules sondes fixees sur au moins une zone active d'un capteur
WO2003066191A1 (en) * 2002-02-04 2003-08-14 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
US6864058B2 (en) * 2002-02-06 2005-03-08 Baylor College Of Medicine Vaccinia topoisomerases I-based assays for detection of specific DNA breaks
US20050084645A1 (en) * 2002-02-07 2005-04-21 Selinfreund Richard H. Method and system for optical disc copy-protection
US20040109793A1 (en) * 2002-02-07 2004-06-10 Mcneely Michael R Three-dimensional microfluidics incorporating passive fluid control structures
US20030152934A1 (en) * 2002-02-11 2003-08-14 Industrial Technology Research Institute High performance nucleic acid hybridization device and process
US8271202B1 (en) 2002-02-11 2012-09-18 Fernandez Dennis S Modified host bio-data management
US6814859B2 (en) * 2002-02-13 2004-11-09 Nanostream, Inc. Frit material and bonding method for microfluidic separation devices
JP3892743B2 (ja) * 2002-03-01 2007-03-14 日本碍子株式会社 反応セルおよびその使用方法
US6819027B2 (en) * 2002-03-04 2004-11-16 Cepheid Method and apparatus for controlling ultrasonic transducer
EP1485191B1 (en) 2002-03-05 2012-08-01 Caliper Life Sciences, Inc. Mixed mode microfluidic system and method
KR100459896B1 (ko) * 2002-03-06 2004-12-04 삼성전자주식회사 Ｐｃｒ 칩을 구동하기 위한 온도 제어 방법 및 그 장치
US20030170637A1 (en) * 2002-03-06 2003-09-11 Pirrung Michael C. Method of analyzing mRNA splice variants
US7303727B1 (en) 2002-03-06 2007-12-04 Caliper Life Sciences, Inc Microfluidic sample delivery devices, systems, and methods
US20030203384A1 (en) * 2002-03-08 2003-10-30 Chafin David R. Multiplex detection of biological materials in a sample
US6869462B2 (en) * 2002-03-11 2005-03-22 Battelle Memorial Institute Methods of contacting substances and microsystem contactors
US20030215941A1 (en) * 2002-03-12 2003-11-20 Stewart Campbell Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound
US6916621B2 (en) * 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
AU2003224817B2 (en) * 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
US7312085B2 (en) * 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
US7419784B2 (en) 2002-04-02 2008-09-02 Dubrow Robert S Methods, systems and apparatus for separation and isolation of one or more sample components of a sample biological material
US20050026134A1 (en) * 2002-04-10 2005-02-03 Bioprocessors Corp. Systems and methods for control of pH and other reactor environment conditions
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US6976590B2 (en) * 2002-06-24 2005-12-20 Cytonome, Inc. Method and apparatus for sorting particles
US6808075B2 (en) * 2002-04-17 2004-10-26 Cytonome, Inc. Method and apparatus for sorting particles
US20030198962A1 (en) * 2002-04-18 2003-10-23 Yung-Chiang Chung Method and apparatus for nucleic acid hybridization
US7648468B2 (en) * 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) * 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7901362B2 (en) * 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) * 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US8360992B2 (en) * 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
EA010903B1 (ru) 2002-04-19 2008-12-30 Дайверса Корпорейшн Фосфолипазы, нуклеиновые кислоты, кодирующие их, и способы их получения и применения
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) * 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US8267870B2 (en) * 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7331931B2 (en) * 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7297122B2 (en) * 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7226771B2 (en) 2002-04-19 2007-06-05 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
US7892185B2 (en) * 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US20070142748A1 (en) * 2002-04-19 2007-06-21 Ajay Deshmukh Tissue penetration device
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) * 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7547287B2 (en) * 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) * 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US9314194B2 (en) * 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8241883B2 (en) 2002-04-24 2012-08-14 Caliper Life Sciences, Inc. High throughput mobility shift
EP1502097A2 (en) 2002-04-26 2005-02-02 Board of Regents, The University of Texas System Method and system for the detection of cardiac risk factors
JPWO2003093835A1 (ja) * 2002-04-30 2005-09-08 アークレイ株式会社 分析用具の温調方法、および温調機能を備えた分析装置
US7399449B1 (en) * 2002-05-14 2008-07-15 Sandia Corporation Microfabricated diffusion source
EP1900827A3 (en) 2002-05-21 2008-04-16 Bayer HealthCare AG Methods and compositions for the prediction, diagnosis, prognosis, prevention and treatment of malignant neoplasia
US20030217923A1 (en) * 2002-05-24 2003-11-27 Harrison D. Jed Apparatus and method for trapping bead based reagents within microfluidic analysis systems
WO2003102142A2 (en) * 2002-05-29 2003-12-11 Henry M. Jackson Foundation For The Advancement Of Military Medicine Inc. Arrays identifying genomic and proteomic biomarkers for cystic fibrosis
US20070026528A1 (en) * 2002-05-30 2007-02-01 Delucas Lawrence J Method for screening crystallization conditions in solution crystal growth
US20030224371A1 (en) * 2002-06-04 2003-12-04 Thomas Bradley S. Integrated cartridge for sample manipulation
US7161356B1 (en) 2002-06-05 2007-01-09 Caliper Life Sciences, Inc. Voltage/current testing equipment for microfluidic devices
US20050106714A1 (en) * 2002-06-05 2005-05-19 Zarur Andrey J. Rotatable reactor systems and methods
JP2005535308A (ja) 2002-06-13 2005-11-24 カイロン コーポレイション Ｈｍｌ−２ポリペプチド発現用ベクター
US6780320B2 (en) * 2002-06-20 2004-08-24 The Regents Of The University Of California Magnetohydrodynamic fluidic system
AU2003243691A1 (en) * 2002-06-20 2004-01-06 Primera Biosystems, Inc. Apparatus for polynucleotide detection and quantitation
FR2841158B1 (fr) * 2002-06-24 2007-02-23 Bio Merieux Dispositif fluidique permettant de maniere thermo-pneumatique l'isolement et eventuellement l'agitation du contenu d'une cavite operatoire
AU2003277853A1 (en) * 2002-06-24 2004-01-06 Fluidigm Corporation Recirculating fluidic network and methods for using the same
US7517656B2 (en) * 2002-07-30 2009-04-14 Trex Enterprises Corp. Optical sensor and methods for measuring molecular binding interactions
US20040005247A1 (en) * 2002-07-03 2004-01-08 Nanostream, Inc. Microfluidic closed-end metering systems and methods
US20040007672A1 (en) * 2002-07-10 2004-01-15 Delucas Lawrence J. Method for distinguishing between biomolecule and non-biomolecule crystals
WO2004007078A1 (en) * 2002-07-12 2004-01-22 British Biocell International Limited Lateral flow assay device and method
WO2004009849A1 (en) * 2002-07-19 2004-01-29 Isis Pharmaceuticals, Inc. Methods for mass spectrometry analysis utilizing an integrated microfluidics sample platform
US20040011650A1 (en) * 2002-07-22 2004-01-22 Frederic Zenhausern Method and apparatus for manipulating polarizable analytes via dielectrophoresis
WO2004009840A1 (en) * 2002-07-24 2004-01-29 Board Of Regents, The University Of Texas System Capture and detection of microbes by membrane methods
US20040023397A1 (en) * 2002-08-05 2004-02-05 Rakesh Vig Tamper-resistant authentication mark for use in product or product packaging authentication
JP2004069498A (ja) * 2002-08-06 2004-03-04 Canon Inc 液体搬送装置及び液体搬送方法
DE10241093A1 (de) * 2002-09-02 2004-03-18 Siemens Ag Mikroreaktor
US7455770B2 (en) * 2002-09-09 2008-11-25 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
US6878271B2 (en) * 2002-09-09 2005-04-12 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
US7094345B2 (en) * 2002-09-09 2006-08-22 Cytonome, Inc. Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system
ITTO20020809A1 (it) * 2002-09-17 2004-03-18 St Microelectronics Srl Micropompa, in particolare per un dispositivo integrato di analisi del dna.
US7279134B2 (en) * 2002-09-17 2007-10-09 Intel Corporation Microfluidic devices with porous membranes for molecular sieving, metering, and separations
ITTO20020808A1 (it) * 2002-09-17 2004-03-18 St Microelectronics Srl Dispositivo integrato di analisi del dna.
US8220494B2 (en) * 2002-09-25 2012-07-17 California Institute Of Technology Microfluidic large scale integration
JP2006501056A (ja) * 2002-09-25 2006-01-12 カリフォルニア インスティテュート オブ テクノロジー ミクロ流体大規模集積
WO2004029914A1 (en) * 2002-09-26 2004-04-08 Verification Technologies, Inc. Authentication of items using transient optical state change materials
TW590982B (en) * 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
EP2359689B1 (en) 2002-09-27 2015-08-26 The General Hospital Corporation Microfluidic device for cell separation and use thereof
JP5695287B2 (ja) 2002-10-02 2015-04-01 カリフォルニア インスティテュート オブ テクノロジー 微小流体の核酸解析
US20050003369A1 (en) * 2002-10-10 2005-01-06 Affymetrix, Inc. Method for depleting specific nucleic acids from a mixture
US9740817B1 (en) 2002-10-18 2017-08-22 Dennis Sunga Fernandez Apparatus for biological sensing and alerting of pharmaco-genomic mutation
US7010964B2 (en) * 2002-10-31 2006-03-14 Nanostream, Inc. Pressurized microfluidic devices with optical detection regions
US20040086872A1 (en) * 2002-10-31 2004-05-06 Childers Winthrop D. Microfluidic system for analysis of nucleic acids
US7932098B2 (en) * 2002-10-31 2011-04-26 Hewlett-Packard Development Company, L.P. Microfluidic system utilizing thin-film layers to route fluid
JP2004184138A (ja) * 2002-11-29 2004-07-02 Nec Corp 分離装置、分離方法、および質量分析システム
JP2006516193A (ja) 2002-12-06 2006-06-29 アイシス・ファーマシューティカルス・インコーポレーテッド ヒトおよび動物における病原体の迅速な同定方法
US20040259111A1 (en) * 2002-12-10 2004-12-23 Rosetta Inpharmatics Llc Automated system and method for preparing an assay ready biological sample
WO2004057027A1 (fr) * 2002-12-11 2004-07-08 Centre National De La Recherche Scientifique Procede de detection electronique d'au moins une interaction specifique entre des molecules sondes et des biomolecules cibles.
EP1578286A4 (en) * 2002-12-13 2009-01-14 Pelikan Technologies Inc METHOD AND APPARATUS FOR MEASURING ANALYTES
US20050042639A1 (en) 2002-12-20 2005-02-24 Caliper Life Sciences, Inc. Single molecule amplification and detection of DNA length
US8275554B2 (en) 2002-12-20 2012-09-25 Caliper Life Sciences, Inc. System for differentiating the lengths of nucleic acids of interest in a sample
CA2510166A1 (en) 2002-12-20 2004-09-30 Caliper Life Sciences, Inc. Single molecule amplification and detection of dna
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
KR101216828B1 (ko) * 2002-12-30 2013-01-04 더 리전트 오브 더 유니버시티 오브 캘리포니아 병원균 검출과 분석을 위한 방법과 기구
WO2004067708A2 (en) * 2003-01-17 2004-08-12 Sri International Et Al. Device and method for fragmenting material by hydrodynamic shear
AU2004206250B8 (en) * 2003-01-21 2009-09-17 Bristol-Myers Squibb Company Polynucleotide encoding a novel acyl coenzyme a, monoacylglycerol acyltransferase-3 (MGAT3), and uses thereof
FR2850323A1 (fr) * 2003-01-23 2004-07-30 Neopost Ind Dispositif separateur pour alimenteur de machine d'affranchissement
US20090186343A1 (en) * 2003-01-28 2009-07-23 Visigen Biotechnologies, Inc. Methods for preparing modified biomolecules, modified biomolecules and methods for using same
US7147955B2 (en) * 2003-01-31 2006-12-12 Societe Bic Fuel cartridge for fuel cells
US20050048573A1 (en) * 2003-02-03 2005-03-03 Plexxikon, Inc. PDE5A crystal structure and uses
US20060203700A1 (en) * 2003-02-06 2006-09-14 Verification Technologies, Inc. Method and system for optical disk copy-protection
US20040157343A1 (en) * 2003-02-06 2004-08-12 Applera Corporation Devices and methods for biological sample preparation
WO2004077021A2 (en) * 2003-02-27 2004-09-10 Lesko Stephen A Standardized evaluation of therapeutic efficacy based on cellular biomarkers
US20050170431A1 (en) * 2003-02-28 2005-08-04 Plexxikon, Inc. PYK2 crystal structure and uses
ES2713024T3 (es) 2003-03-06 2019-05-17 Basf Enzymes Llc Amilasas, ácidos nucleicos que las codifican y métodos para su fabricación y uso
CA2515583C (en) 2003-03-07 2015-07-14 Diversa Corporation Hydrolases, nucleic acids encoding them and methods for making and using them
US20040179972A1 (en) * 2003-03-14 2004-09-16 Nanostream, Inc. Systems and methods for detecting manufacturing defects in microfluidic devices
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
EP1473085B1 (en) * 2003-03-31 2015-07-22 Canon Kabushiki Kaisha Biochemical reaction cartridge
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
AU2004228678A1 (en) * 2003-04-03 2004-10-21 Fluidigm Corp. Microfluidic devices and methods of using same
US7476363B2 (en) * 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US8828663B2 (en) * 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
US7604965B2 (en) * 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US20030157503A1 (en) * 2003-04-04 2003-08-21 Mcgarry Mark W Compositions and methods for performing biological reactions
WO2004090099A2 (en) 2003-04-04 2004-10-21 Diversa Corporation Pectate lyases, nucleic acids encoding them and methods for making and using them
US7178386B1 (en) 2003-04-10 2007-02-20 Nanostream, Inc. Parallel fluid processing systems and methods
US7981600B2 (en) * 2003-04-17 2011-07-19 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using an anion exchange material that includes a polyoxyalkylene
WO2004094020A2 (en) * 2003-04-17 2004-11-04 Fluidigm Corporation Crystal growth devices and systems, and methods for using same
US8046171B2 (en) * 2003-04-18 2011-10-25 Ibis Biosciences, Inc. Methods and apparatus for genetic evaluation
DE10318139B4 (de) * 2003-04-18 2005-02-17 PRO DESIGN Gesellschaft für Produktentwicklung mbH Selbstkonfigurerbarer Biochip
US20050064452A1 (en) * 2003-04-25 2005-03-24 Schmid Matthew J. System and method for the detection of analytes
DE10319045A1 (de) * 2003-04-25 2004-12-09 november Aktiengesellschaft Gesellschaft für Molekulare Medizin Vorrichtung und Verfahren zur Aufbereitung Biopolymerhaltiger Flüssigkeiten
US8057993B2 (en) 2003-04-26 2011-11-15 Ibis Biosciences, Inc. Methods for identification of coronaviruses
EP1620021A4 (en) * 2003-05-02 2008-06-18 Pelikan Technologies Inc METHOD AND DEVICE FOR A USER INTERFACE FOR A TISSUE PEGETRATION DEVICE
US7074327B2 (en) * 2003-05-08 2006-07-11 Nanostream, Inc. Sample preparation for parallel chromatography
US6948143B2 (en) * 2003-05-09 2005-09-20 Synopsys, Inc. Constrained optimization with linear constraints to remove overlap among cells of an integrated circuit
US8158354B2 (en) * 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7964343B2 (en) * 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US9317922B2 (en) 2003-05-16 2016-04-19 Board Of Regents The University Of Texas System Image and part recognition technology
WO2004104922A2 (en) * 2003-05-16 2004-12-02 Board Of Regents, The University Of Texas System Image and part recognition technology
US7695683B2 (en) * 2003-05-20 2010-04-13 Fluidigm Corporation Method and system for microfluidic device and imaging thereof
US7435391B2 (en) * 2003-05-23 2008-10-14 Lucent Technologies Inc. Light-mediated micro-chemical reactors
WO2004107975A2 (en) 2003-05-30 2004-12-16 Pelikan Technologies, Inc. Method and apparatus for fluid injection
KR100706464B1 (ko) * 2003-05-30 2007-04-10 애플라 코포레이션 혼성화 및 에스피알 검출을 위한 장치 및 방법
US20050026273A1 (en) * 2003-06-05 2005-02-03 Zarur Andrey J. Reactor with memory component
WO2004107964A2 (en) * 2003-06-06 2004-12-16 Pelikan Technologies, Inc. Blood harvesting device with electronic control
US20040248323A1 (en) 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
US20050170367A1 (en) * 2003-06-10 2005-08-04 Quake Stephen R. Fluorescently labeled nucleoside triphosphates and analogs thereof for sequencing nucleic acids
EP1635702A4 (en) * 2003-06-11 2009-01-21 Pelikan Technologies Inc METHOD AND APPARATUS FOR SAMPLING BODY LIQUID AND ANALYTE DETECTION
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
WO2004113877A1 (en) * 2003-06-13 2004-12-29 The General Hospital Corporation Microfluidic systems for size based removal of red blood cells and platelets from blood
US7597793B2 (en) 2003-06-20 2009-10-06 Roche Operations Ltd. System and method for analyte measurement employing maximum dosing time delay
US7604721B2 (en) 2003-06-20 2009-10-20 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US8206565B2 (en) 2003-06-20 2012-06-26 Roche Diagnostics Operation, Inc. System and method for coding information on a biosensor test strip
US7718439B2 (en) 2003-06-20 2010-05-18 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US7601545B2 (en) * 2003-06-20 2009-10-13 Groton Biosystems, Llc Automated macromolecule sample preparation system
US7488601B2 (en) 2003-06-20 2009-02-10 Roche Diagnostic Operations, Inc. System and method for determining an abused sensor during analyte measurement
US8058077B2 (en) 2003-06-20 2011-11-15 Roche Diagnostics Operations, Inc. Method for coding information on a biosensor test strip
US7452457B2 (en) 2003-06-20 2008-11-18 Roche Diagnostics Operations, Inc. System and method for analyte measurement using dose sufficiency electrodes
US8148164B2 (en) 2003-06-20 2012-04-03 Roche Diagnostics Operations, Inc. System and method for determining the concentration of an analyte in a sample fluid
US7645421B2 (en) 2003-06-20 2010-01-12 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US7645373B2 (en) 2003-06-20 2010-01-12 Roche Diagnostic Operations, Inc. System and method for coding information on a biosensor test strip
WO2005003395A1 (en) * 2003-07-02 2005-01-13 Caliper Life Sciences, Inc. Method for amplifying and detecting nucleic acids in microfluidic devices under continuous and non-continuous flow conditions
BRPI0412279A (pt) 2003-07-02 2006-09-19 Diversa Corp glucanases, ácidos nucléicos codificando as mesmas e métodos para preparar e aplicar os mesmos
US20050079548A1 (en) * 2003-07-07 2005-04-14 Plexxikon, Inc. Ligand development using PDE4B crystal structures
US7504070B2 (en) * 2003-07-11 2009-03-17 Ngk Insulators, Ltd. Micro reactor
EP1645329A4 (en) * 2003-07-11 2010-05-19 Ngk Insulators Ltd MICRO REACTOR
ATE531817T1 (de) * 2003-07-15 2011-11-15 Lukas Bestmann Probenzubereitungseinheit
JP4067463B2 (ja) * 2003-07-18 2008-03-26 トヨタ自動車株式会社 ハイブリッド車輌の制御装置
CA2532530A1 (en) * 2003-07-28 2005-02-10 Fluidigm Corporation Image processing method and system for microfluidic devices
JP4996248B2 (ja) 2003-07-31 2012-08-08 ハンディーラブ インコーポレイテッド 粒子含有サンプルの処理
US7335984B2 (en) * 2003-07-31 2008-02-26 Agency For Science, Technology And Research Microfluidics chips and methods of using same
US20050033133A1 (en) * 2003-08-06 2005-02-10 Clifford Kraft Implantable chip medical diagnostic device for bodily fluids
US20050032238A1 (en) * 2003-08-07 2005-02-10 Nanostream, Inc. Vented microfluidic separation devices and methods
US7413712B2 (en) * 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
EP1668113B1 (en) 2003-08-11 2013-06-19 Verenium Corporation Laccases, nucleic acids encoding them and methods for making and using them
US7111466B2 (en) * 2003-08-21 2006-09-26 Yamaha Corporation Microreactor and substance production method therewith
US8346482B2 (en) * 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
US7198900B2 (en) * 2003-08-29 2007-04-03 Applera Corporation Multiplex detection compositions, methods, and kits
US20050048498A1 (en) * 2003-08-29 2005-03-03 Applera Corporation Compositions, methods, and kits for assembling probes
US20050069895A1 (en) * 2003-08-29 2005-03-31 Applera Corporation Compositions, methods, and kits for fabricating coded molecular tags
US8131475B2 (en) 2003-09-03 2012-03-06 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Methods for identifying, diagnosing, and predicting survival of lymphomas
US7711492B2 (en) 2003-09-03 2010-05-04 The United States Of America As Represented By The Department Of Health And Human Services Methods for diagnosing lymphoma types
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8394945B2 (en) * 2003-09-11 2013-03-12 Ibis Biosciences, Inc. Compositions for use in identification of bacteria
US20060240412A1 (en) * 2003-09-11 2006-10-26 Hall Thomas A Compositions for use in identification of adenoviruses
US20080138808A1 (en) * 2003-09-11 2008-06-12 Hall Thomas A Methods for identification of sepsis-causing bacteria
US20100035239A1 (en) * 2003-09-11 2010-02-11 Isis Pharmaceuticals, Inc. Compositions for use in identification of bacteria
WO2005028624A2 (en) * 2003-09-15 2005-03-31 Plexxikon, Inc. Molecular scaffolds for kinase ligand development
US7407630B2 (en) 2003-09-19 2008-08-05 Applera Corporation High density plate filler
WO2005031163A1 (en) * 2003-09-25 2005-04-07 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
EP1522594A3 (en) 2003-10-06 2005-06-22 Bayer HealthCare AG Methods and kits for investigating cancer
US20050074784A1 (en) * 2003-10-07 2005-04-07 Tuan Vo-Dinh Integrated biochip with continuous sampling and processing (CSP) system
WO2005037095A1 (en) * 2003-10-14 2005-04-28 Pelikan Technologies, Inc. Method and apparatus for a variable user interface
US7032605B1 (en) 2003-10-15 2006-04-25 Douglas B. Dority Dual piston rotary valve
US20070212689A1 (en) * 2003-10-30 2007-09-13 Bianchi Diana W Prenatal Diagnosis Using Cell-Free Fetal DNA in Amniotic Fluid
US20050287668A1 (en) * 2003-11-04 2005-12-29 Cell Therapeutics, Inc. (Cti) RNA interference compositions and screening methods for the identification of novel genes and biological pathways
EP1685395A2 (en) * 2003-11-05 2006-08-02 EXACT Sciences Corporation Repetitive reversed-field affinity electrophoresis and uses therefor
US8007724B2 (en) * 2003-11-07 2011-08-30 Princeton Biochemicals, Inc. Electrophoresis apparatus having at least one auxiliary buffer passage
WO2005047882A2 (en) * 2003-11-07 2005-05-26 Princeton Biochemicals, Inc. Multi-dimensional electrophoresis apparatus
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
DE10353985A1 (de) * 2003-11-19 2005-06-23 Olympus Biosystems Gmbh Einrichtung und Verfahren zum Manipulieren und Analysieren von Mikroobjekten auf Grundlage eines zumindest bereichsweise als fluidisches Mikrosystem oder/und Chipsystem ausgeführten Mikrosystems
US7238521B2 (en) * 2003-11-24 2007-07-03 Biocept, Inc. Microarray hybridization device having bubble-fracturing elements
EP1535665A1 (en) * 2003-11-28 2005-06-01 STMicroelectronics S.r.l. Integrated chemical microreactor with separated channels for confining liquids inside the channels and manufacturing process thereof
WO2005054441A2 (en) * 2003-12-01 2005-06-16 California Institute Of Technology Device for immobilizing chemical and biomedical species and methods of using same
JP2007512838A (ja) 2003-12-01 2007-05-24 インヴィトロジェン コーポレーション 組換え部位を含む核酸分子およびその使用方法
CA2549190A1 (en) * 2003-12-11 2005-06-30 Board Of Regents, The University Of Texas System Method and system for the analysis of saliva using a sensor array
US7322254B2 (en) * 2003-12-12 2008-01-29 3M Innovative Properties Company Variable valve apparatus and methods
EP1541991A1 (en) * 2003-12-12 2005-06-15 STMicroelectronics S.r.l. Integrated semiconductor chemical microreactor for real-time monitoring of biological reactions
US20050130177A1 (en) * 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
DK1696920T3 (en) * 2003-12-19 2015-01-19 Plexxikon Inc RELATIONS AND PROCEDURES FOR THE DEVELOPMENT OF LAW MODULATORS
EP1547688A1 (en) * 2003-12-23 2005-06-29 STMicroelectronics S.r.l. Microfluidic device and method of locally concentrating electrically charged substances in a microfluidic device
US20050161327A1 (en) * 2003-12-23 2005-07-28 Michele Palmieri Microfluidic device and method for transporting electrically charged substances through a microchannel of a microfluidic device
US20050142570A1 (en) * 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and sedimenting reagent
US20050142571A1 (en) * 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using solid phase material
US7939249B2 (en) * 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
WO2005065414A2 (en) 2003-12-31 2005-07-21 Pelikan Technologies, Inc. Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) * 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
JP4246642B2 (ja) * 2004-01-15 2009-04-02 株式会社日立プラントテクノロジー マイクロ流体システム
US7407799B2 (en) 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat
US20050164373A1 (en) * 2004-01-22 2005-07-28 Oldham Mark F. Diffusion-aided loading system for microfluidic devices
WO2005072353A2 (en) * 2004-01-25 2005-08-11 Fluidigm Corporation Crystal forming devices and systems and methods for making and using the same
CN102357352B (zh) 2004-01-26 2015-08-12 哈佛大学 流体递送系统和方法
US8030057B2 (en) 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
US20050170401A1 (en) * 2004-01-29 2005-08-04 Canon Kabushiki Kaisha Hybridization apparatus and method
US20050176135A1 (en) * 2004-02-06 2005-08-11 Brian Jones Cassette for isolation, amplification and identification of DNA or protein and method of use
BRPI0507376A (pt) 2004-02-06 2007-07-10 Bayer Healthcare Llc espécie oxidável como uma referência interna para biossensores e método de uso
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
DE602005020421D1 (de) 2004-02-19 2010-05-20 Helicos Biosciences Corp Verfahren zur analyse von polynukleotidsequenzen
US8043849B2 (en) * 2004-02-24 2011-10-25 Thermal Gradient Thermal cycling device
EP2354256B1 (en) * 2004-02-24 2019-04-10 Thermal Gradient Thermal cycling device
US8105849B2 (en) * 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US20060257991A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements
US20060257854A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Membrane assay system including preloaded particles
US7781226B2 (en) * 2004-02-27 2010-08-24 The Board Of Regents Of The University Of Texas System Particle on membrane assay system
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US20060046258A1 (en) * 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
US20060257941A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle and membrane sensor elements
US8119336B2 (en) * 2004-03-03 2012-02-21 Ibis Biosciences, Inc. Compositions for use in identification of alphaviruses
US20060121624A1 (en) * 2004-03-03 2006-06-08 Huang Lotien R Methods and systems for fluid delivery
WO2005084380A2 (en) * 2004-03-03 2005-09-15 The General Hospital Corporation System for delivering a diluted solution
US7588724B2 (en) * 2004-03-05 2009-09-15 Bayer Healthcare Llc Mechanical device for mixing a fluid sample with a treatment solution
JP4127679B2 (ja) * 2004-03-18 2008-07-30 株式会社東芝 核酸検出カセット及び核酸検出装置
KR20080075045A (ko) 2004-03-24 2008-08-13 트리패스 이미징, 인코포레이티드 자궁경부 질환의 검사 방법 및 조성물
US7432106B2 (en) * 2004-03-24 2008-10-07 Applied Biosystems Inc. Liquid processing device including gas trap, and system and method
WO2005098048A1 (en) * 2004-03-25 2005-10-20 The Board Of Trustees Of The Leland Stanford Junior University Protein expression yield enhancement in cell-free protein synthesis systems by addition of antifoam agents
US20050220644A1 (en) * 2004-03-31 2005-10-06 Sebastian Bohm Pneumatic actuator for bolus generation in a fluid handling circuit
US20050220630A1 (en) * 2004-03-31 2005-10-06 Sebastian Bohm Method of using triggerable passive valves to control the flow of fluid
US7156117B2 (en) * 2004-03-31 2007-01-02 Lifescan Scotland Limited Method of controlling the movement of fluid through a microfluidic circuit using an array of triggerable passive valves
US7665303B2 (en) * 2004-03-31 2010-02-23 Lifescan Scotland, Ltd. Method of segregating a bolus of fluid using a pneumatic actuator in a fluid handling circuit
US7059352B2 (en) * 2004-03-31 2006-06-13 Lifescan Scotland Triggerable passive valve for use in controlling the flow of fluid
US20050217742A1 (en) * 2004-03-31 2005-10-06 Sebastian Bohm Microfluidic circuit including an array of triggerable passive valves
US7387877B2 (en) * 2004-04-06 2008-06-17 Oro Grande Technology Bio-sensor and bio-sensor reporting system
ATE491043T1 (de) 2004-04-09 2010-12-15 Us Gov Health & Human Serv Diagnosegerät zur diagnose gutartiger gegenüber bösartigen schilddrüsenläsionen
ATE497837T1 (de) * 2004-04-09 2011-02-15 Vivebio Llc Vorrichtungen und verfahren für abnahme, lagerung und transport von biologischen proben
US20050239085A1 (en) * 2004-04-23 2005-10-27 Buzby Philip R Methods for nucleic acid sequence determination
JP4592060B2 (ja) 2004-04-26 2010-12-01 キヤノン株式会社 Ｐｃｒ増幅反応装置、ならびに、該装置を利用するｐｃｒ増幅反応方法
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
CA2994321C (en) * 2004-05-03 2023-08-08 Handylab, Inc. A microfluidic device and methods for processing polynucleotide-containing samples
CN1981186B (zh) 2004-05-04 2012-06-20 拜耳医药保健有限公司 用于流体分析仪的具有测试带流体控制特征的机械卡盒
EP1742627A4 (en) 2004-05-06 2009-08-26 Plexxikon Inc PDE4B HEMMER AND ITS USE
CN100516212C (zh) * 2004-05-07 2009-07-22 柯尼卡美能达医疗印刷器材株式会社 检测用微型反应器、基因检测装置和基因检测方法
AU2016203092B2 (en) * 2004-05-13 2017-10-05 Nanobiosym, Inc. Nano-pcr: methods and devices for nucleic acid amplification and detection
CA2567627C (en) * 2004-05-20 2014-09-30 Quest Diagnostics Investments Incorporated Single label comparative hybridization
WO2006011062A2 (en) 2004-05-20 2006-02-02 Albatros Technologies Gmbh & Co. Kg Printable hydrogel for biosensors
ES2641832T3 (es) 2004-05-24 2017-11-14 Ibis Biosciences, Inc. Espectrometría de masas con filtración de iones selectiva por establecimiento de umbrales digitales
US20050260609A1 (en) * 2004-05-24 2005-11-24 Lapidus Stanley N Methods and devices for sequencing nucleic acids
US20070117103A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
DE602005027700D1 (de) 2004-05-25 2011-06-09 Helicos Biosciences Corp Verfahren zur nukleinsäureimmobilisierung
US20070117104A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
US7476734B2 (en) 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
US20050266411A1 (en) * 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7622296B2 (en) * 2004-05-28 2009-11-24 Wafergen, Inc. Apparatus and method for multiplex analysis
US7799553B2 (en) 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
US7338763B2 (en) * 2004-06-02 2008-03-04 Eppendorf Array Technologies S.A. Method and kit for the detection and/or quantification of homologous nucleotide sequences on arrays
US20060024751A1 (en) * 2004-06-03 2006-02-02 Fluidigm Corporation Scale-up methods and systems for performing the same
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
EP1761331A2 (en) * 2004-06-07 2007-03-14 Bioprocessors Corporation Control of reactor environmental conditions
WO2005121307A2 (en) * 2004-06-07 2005-12-22 Bioprocessor Corp. Gas control in a microreactor
US20050277187A1 (en) * 2004-06-07 2005-12-15 Bioprocessors Corp. Creation of shear in a reactor
EP1765487A1 (en) * 2004-06-07 2007-03-28 Bioprocessors Corporation Reactor mixing
ES2461857T3 (es) 2004-06-16 2014-05-21 Dsm Ip Assets B.V. Composiciones y métodos para la decoloración enzimática de clorofila
WO2006009797A1 (en) * 2004-06-17 2006-01-26 Plexxikon, Inc. Azaindoles modulating c-kit activity and uses therefor
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
US7556723B2 (en) 2004-06-18 2009-07-07 Roche Diagnostics Operations, Inc. Electrode design for biosensor
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip
US8536661B1 (en) 2004-06-25 2013-09-17 University Of Hawaii Biosensor chip sensor protection methods
US7776530B2 (en) * 2004-06-29 2010-08-17 Wallac Oy Integrated nucleic acid analysis
US8965710B2 (en) * 2004-07-02 2015-02-24 The United States Of America, As Represented By The Secretary Of The Navy Automated sample-to-microarray apparatus and method
ITBO20040420A1 (it) 2004-07-07 2004-10-07 Type S R L Macchina per taglio e formatura di piattine metalliche
US7615370B2 (en) * 2004-07-08 2009-11-10 Tecan Trading Ag System having device for preventing air bubbles in a hybridization chamber and corresponding method
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
JP4756835B2 (ja) * 2004-07-14 2011-08-24 キヤノン株式会社 生化学反応カートリッジ
US20060024678A1 (en) * 2004-07-28 2006-02-02 Helicos Biosciences Corporation Use of single-stranded nucleic acid binding proteins in sequencing
US20060024206A1 (en) * 2004-07-29 2006-02-02 Sinha Naveen N Non-invasive acoustic technique for mixing and segregation of fluid suspensions in microfluidic applications
US7611840B2 (en) * 2004-08-03 2009-11-03 Agency For Science, Technology And Research Method and device for the treatment of biological samples
WO2006135400A2 (en) 2004-08-24 2006-12-21 Isis Pharmaceuticals, Inc. Methods for rapid identification of recombinant organisms
CN101048407A (zh) * 2004-09-03 2007-10-03 普莱希科公司 双环杂芳基pde4b抑制剂
EP1794581A2 (en) 2004-09-15 2007-06-13 Microchip Biotechnologies, Inc. Microfluidic devices
WO2006044078A2 (en) * 2004-09-17 2006-04-27 Pacific Biosciences Of California, Inc. Apparatus and method for analysis of molecules
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
WO2006036592A1 (en) 2004-09-23 2006-04-06 University Of Washington Microscale diffusion immunoassay utilizing multivalent reactants
DE102004046618A1 (de) * 2004-09-25 2006-03-30 Robert Bosch Gmbh Schaltungsanordnung zum Analog/Digital-Wandeln
GB0421529D0 (en) 2004-09-28 2004-10-27 Landegren Gene Technology Ab Microfluidic structure
CN101031801B (zh) * 2004-09-30 2010-12-01 爱科来株式会社 薄膜加热器和分析用具
WO2006038643A1 (ja) * 2004-10-06 2006-04-13 Universal Bio Research Co., Ltd. 反応容器、および反応制御装置
US7832429B2 (en) 2004-10-13 2010-11-16 Rheonix, Inc. Microfluidic pump and valve structures and fabrication methods
US7608160B2 (en) 2004-10-13 2009-10-27 Rheonix, Inc. Laminated microfluidic structures and method for making
DE102004050139B4 (de) * 2004-10-14 2008-12-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Mikrofluidprozessor und Verfahren zur Durchführung einer Polymerasekettenreaktion
DE102004050510B4 (de) * 2004-10-15 2012-01-12 Siemens Ag Verfahren zur Ventilsteuerung bei der Thermozyklisierung einer Substanz zwecks PCR und zugehörige Anordnung
EP1650297B1 (en) * 2004-10-19 2011-04-13 Samsung Electronics Co., Ltd. Method and apparatus for the rapid disruption of cells or viruses using micro magnetic beads and laser
CA2585970A1 (en) 2004-10-27 2006-05-04 Vanderbilt University Mammalian genes involved in infection
EP1809765A2 (en) * 2004-11-04 2007-07-25 Roche Diagnostics GmbH Classification of acute myeloid leukemia
US20060094028A1 (en) * 2004-11-04 2006-05-04 Welch Allyn, Inc. Rapid diagnostic assay
DE102004056735A1 (de) 2004-11-09 2006-07-20 Clondiag Chip Technologies Gmbh Vorrichtung für die Durchführung und Analyse von Mikroarray-Experimenten
US20080009002A1 (en) * 2004-11-09 2008-01-10 The Regents Of The University Of California Analyte Identification Using Electronic Devices
US7785785B2 (en) 2004-11-12 2010-08-31 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for DNA and other molecules
EP1658898A1 (en) * 2004-11-20 2006-05-24 Roche Diagnostics GmbH Nucleic acid preparation
CN100388967C (zh) * 2004-12-02 2008-05-21 鸿富锦精密工业（深圳）有限公司 颗粒分散方法及其设备
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US20060118754A1 (en) * 2004-12-08 2006-06-08 Lapen Daniel C Stabilizing a polyelectrolyte multilayer
TWI243705B (en) * 2004-12-22 2005-11-21 Ind Tech Res Inst Fluid analytical device
EP1830961A2 (en) * 2004-12-23 2007-09-12 Koninklijke Philips Electronics N.V. Method for controlling the flow of liquids containing biological material by inducing electro- or magneto-rheological effect
CA2592204C (en) 2004-12-23 2013-03-12 I-Stat Corporation Nucleic acid diagnostics system and methods
US20080214917A1 (en) * 2004-12-30 2008-09-04 Dirk Boecker Method and apparatus for analyte measurement test time
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
US20060167382A1 (en) * 2004-12-30 2006-07-27 Ajay Deshmukh Method and apparatus for storing an analyte sampling and measurement device
US7220549B2 (en) * 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
EP1838875A4 (en) * 2004-12-30 2010-08-25 Todd M Hauser COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION USING SELF-PROTECTED OLIGONUCLEOTIDES
US20060172328A1 (en) * 2005-01-05 2006-08-03 Buzby Philip R Methods and compositions for correcting misincorporation in a nucleic acid synthesis reaction
US20060171846A1 (en) * 2005-01-10 2006-08-03 Marr David W M Microfluidic systems incorporating integrated optical waveguides
WO2006076567A2 (en) * 2005-01-13 2006-07-20 Micronics, Inc. Microfluidic rare cell detection device
US7391936B2 (en) * 2005-01-21 2008-06-24 Lucent Technologies, Inc. Microfluidic sensors and methods for making the same
DE602006018861D1 (de) * 2005-01-27 2011-01-27 Quest Diagnostics Invest Inc Schnelle komparative genomhybridisierung
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
US8738106B2 (en) * 2005-01-31 2014-05-27 Given Imaging, Ltd Device, system and method for in vivo analysis
US20060184065A1 (en) * 2005-02-10 2006-08-17 Ajay Deshmukh Method and apparatus for storing an analyte sampling and measurement device
EP1856282A4 (en) * 2005-02-15 2009-05-13 Univ Virginia Nucleic acid isolation methods and materials and devices thereof
JP2008529538A (ja) * 2005-02-16 2008-08-07 ジェネティック テクノロジーズ リミテッド 相補性デュプリコンの増幅を含む遺伝子分析方法
US20060199187A1 (en) * 2005-03-02 2006-09-07 Meyerhoff Mark E Enzyme amplified electrochemical DNA detection
US8084207B2 (en) * 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
US20060205040A1 (en) * 2005-03-03 2006-09-14 Rangarajan Sampath Compositions for use in identification of adventitious viruses
EP1869174B1 (en) 2005-03-10 2015-02-18 BASF Enzymes LLC Lyase enzymes, nucleic acids encoding them and methods for making and using them
US7964413B2 (en) * 2005-03-10 2011-06-21 Gen-Probe Incorporated Method for continuous mode processing of multiple reaction receptacles in a real-time amplification assay
CA2611859C (en) 2005-03-15 2015-03-31 Verenium Corporation Cellulases, nucleic acids encoding them and methods for making and using them
JP4548174B2 (ja) * 2005-03-24 2010-09-22 コニカミノルタエムジー株式会社 検査用マイクロチップおよびそれを用いた検査装置
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
WO2006113440A2 (en) * 2005-04-15 2006-10-26 Worcester Polytechnic Institute Multi-transduction mechanism based microfluidic analyte sensors
US20070014695A1 (en) * 2005-04-26 2007-01-18 Applera Corporation Systems and Methods for Multiple Analyte Detection
TWI274824B (en) * 2005-05-09 2007-03-01 Li Bing Huan Method of operating and viewing of liquid in a vacuum or low pressure environment and an apparatus for the same
ES2752000T3 (es) 2005-05-09 2020-04-02 Biofire Diagnostics Llc Análisis biológico autónomo
WO2006120221A1 (en) * 2005-05-12 2006-11-16 Stmicroelectronics S.R.L. Microfluidic device with integrated micropump, in particular biochemical microreactor, and manufacturing method thereof
MX2007014377A (es) 2005-05-17 2008-02-06 Plexxikon Inc Inhibidores de proteina cinasa de derivados de pirrol (2,3-b) piridina.
JP5421590B2 (ja) 2005-05-18 2014-02-19 ノバルティス アーゲー 自己免疫および／または炎症性成分を有する疾患の診断および治療のための方法
US20060263790A1 (en) * 2005-05-20 2006-11-23 Timothy Harris Methods for improving fidelity in a nucleic acid synthesis reaction
US8377398B2 (en) 2005-05-31 2013-02-19 The Board Of Regents Of The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
US20060280029A1 (en) * 2005-06-13 2006-12-14 President And Fellows Of Harvard College Microfluidic mixer
EP2255880B1 (de) 2005-06-21 2014-05-28 Tecan Trading AG Verfahren zum Verhindern von Luftblasen in Hybridisierkammern
WO2007002433A1 (en) * 2005-06-22 2007-01-04 Plexxikon, Inc. Pyrrolo [2, 3-b] pyridine derivatives as protein kinase inhibitors
WO2006136990A2 (en) * 2005-06-23 2006-12-28 Koninklijke Philips Electronics N.V. Cartridge, system and method for automated medical diagnostics
US20100291588A1 (en) * 2005-06-24 2010-11-18 The Board Of Regents Of The University Of Texas System Systems and methods including self-contained cartridges with detection systems and fluid delivery systems
WO2007005666A2 (en) * 2005-07-01 2007-01-11 Board Of Regents, The University Of Texas System System and method of analyte detection using differential receptors
US7754474B2 (en) * 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
US7763210B2 (en) * 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US9388374B2 (en) 2005-07-07 2016-07-12 Emd Millipore Corporation Microfluidic cell culture systems
US8257964B2 (en) 2006-01-04 2012-09-04 Cell ASIC Microwell cell-culture device and fabrication method
EP3029135B1 (en) 2005-07-07 2021-03-17 The Regents of the University of California Apparatus for cell culture array
US9637715B2 (en) 2005-07-07 2017-05-02 Emd Millipore Corporation Cell culture and invasion assay method and system
US9354156B2 (en) 2007-02-08 2016-05-31 Emd Millipore Corporation Microfluidic particle analysis method, device and system
EP1904652A2 (en) * 2005-07-08 2008-04-02 Brystol-Myers Squibb Company Single nucleotide polymorphisms associated with dose-dependent edema and methods of use thereof
US7754873B2 (en) * 2005-07-16 2010-07-13 Zymo Research Corporation Isolation of nucleic acid using colored buffers
ITBO20050481A1 (it) 2005-07-19 2007-01-20 Silicon Biosystems S R L Metodo ed apparato per la manipolazione e/o l'individuazione di particelle
BRPI0613592A2 (pt) 2005-07-20 2011-01-18 Bayer Healthcare Llc amperometria conectada por porta
WO2007014045A2 (en) * 2005-07-21 2007-02-01 Isis Pharmaceuticals, Inc. Methods for rapid identification and quantitation of nucleic acid variants
US8921102B2 (en) * 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
EP1920071B1 (en) 2005-07-29 2018-12-26 Siemens Healthcare Diagnostics Inc. Neoplastic disease-related methods, kits, systems and databases
US20070202512A1 (en) * 2005-08-19 2007-08-30 Bristol-Myers Squibb Company Human single nucleotide polymorphisms associated with dose-dependent weight gain and methods of use thereof
WO2007024914A2 (en) * 2005-08-22 2007-03-01 Applera Corporation Device and method for microfluidic control of a first fluid in contact with a second fluid, wherein the first and second fluids are immiscible
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US7425712B2 (en) * 2005-09-01 2008-09-16 Contrel Technology Co., Ltd. Method of operating liquid in the vacuum or low-pressure environment and observing the operation and device for the operation and observation
US7938573B2 (en) * 2005-09-02 2011-05-10 Genefluidics, Inc. Cartridge having variable volume reservoirs
WO2007040913A1 (en) 2005-09-30 2007-04-12 Bayer Healthcare Llc Gated voltammetry
US7962291B2 (en) 2005-09-30 2011-06-14 Affymetrix, Inc. Methods and computer software for detecting splice variants
US20070276290A1 (en) * 2005-10-04 2007-11-29 Dirk Boecker Tissue Penetrating Apparatus
US20070191736A1 (en) * 2005-10-04 2007-08-16 Don Alden Method for loading penetrating members in a collection device
CA2598597C (en) * 2005-10-06 2013-10-15 Technological Resources Pty Limited Gravity gradiometer
WO2007044599A2 (en) * 2005-10-06 2007-04-19 Hamilton Scott E Pod connected data monitoring system
JP2009511059A (ja) * 2005-10-11 2009-03-19 ハンディーラブ インコーポレイテッド ポリヌクレオチドサンプル調製装置
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US8372340B2 (en) * 2005-10-19 2013-02-12 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
ITBO20050646A1 (it) 2005-10-26 2007-04-27 Silicon Biosystem S R L Metodo ed apparato per la caratterizzazione ed il conteggio di particelle
US7947223B2 (en) * 2005-10-31 2011-05-24 Senzime Ab Biosensor apparatus for detection of thermal flow
US20080311585A1 (en) * 2005-11-02 2008-12-18 Affymetrix, Inc. System and method for multiplex liquid handling
US8075852B2 (en) * 2005-11-02 2011-12-13 Affymetrix, Inc. System and method for bubble removal
US8007267B2 (en) * 2005-11-02 2011-08-30 Affymetrix, Inc. System and method for making lab card by embossing
US20080038714A1 (en) * 2005-11-02 2008-02-14 Affymetrix, Inc. Instrument to Pneumatically Control Lab Cards and Method Thereof
US20080038713A1 (en) * 2005-11-02 2008-02-14 Affymetrix, Inc. System and Method for Biological Assay
US20070099288A1 (en) * 2005-11-02 2007-05-03 Affymetrix, Inc. Microfluidic Methods, Devices, and Systems for Fluid Handling
US8936590B2 (en) 2005-11-09 2015-01-20 The Invention Science Fund I, Llc Acoustically controlled reaction device
US20070106275A1 (en) 2005-11-09 2007-05-10 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Reaction device controlled by RF control signal
US8273071B2 (en) 2006-01-18 2012-09-25 The Invention Science Fund I, Llc Remote controller for substance delivery system
US7942867B2 (en) 2005-11-09 2011-05-17 The Invention Science Fund I, Llc Remotely controlled substance delivery device
US9028467B2 (en) 2005-11-09 2015-05-12 The Invention Science Fund I, Llc Osmotic pump with remotely controlled osmotic pressure generation
US8083710B2 (en) 2006-03-09 2011-12-27 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US8992511B2 (en) 2005-11-09 2015-03-31 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
WO2007142692A2 (en) * 2005-11-14 2007-12-13 The Government Of The Usa, As Represented By The Secretary Of The Navy Automated sample-to-microarray system
WO2007061943A2 (en) * 2005-11-21 2007-05-31 Applera Corporation Portable preparation, analysis, and detection apparatus for nucleic acid processing
US20070117102A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
US8076074B2 (en) 2005-11-29 2011-12-13 Quest Diagnostics Investments Incorporated Balanced translocation in comparative hybridization
US7763453B2 (en) 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
US9056291B2 (en) 2005-11-30 2015-06-16 Micronics, Inc. Microfluidic reactor system
US20070128610A1 (en) * 2005-12-02 2007-06-07 Buzby Philip R Sample preparation method and apparatus for nucleic acid sequencing
WO2007069882A1 (en) * 2005-12-13 2007-06-21 Erasmus University Medical Center Rotterdam Genetic brain tumor markers
US20070198653A1 (en) * 2005-12-30 2007-08-23 Kurt Jarnagin Systems and methods for remote computer-based analysis of user-provided chemogenomic data
US8119976B2 (en) * 2007-07-03 2012-02-21 Colorado School Of Mines Optical-based cell deformability
US9487812B2 (en) 2012-02-17 2016-11-08 Colorado School Of Mines Optical alignment deformation spectroscopy
US9878326B2 (en) * 2007-09-26 2018-01-30 Colorado School Of Mines Fiber-focused diode-bar optical trapping for microfluidic manipulation
US9885644B2 (en) 2006-01-10 2018-02-06 Colorado School Of Mines Dynamic viscoelasticity as a rapid single-cell biomarker
SG134186A1 (en) * 2006-01-12 2007-08-29 Nanyang Polytechnic Smart nano-integrated system assembly
EP1989326A4 (en) 2006-01-17 2009-09-30 Health Research Inc BIO-HETERODUPLEX TRACKING TEST
JP5000666B2 (ja) * 2006-01-25 2012-08-15 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 流体を分析する装置
AU2007211085A1 (en) 2006-01-27 2007-08-09 Tripath Imaging, Inc. Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor
US7749365B2 (en) 2006-02-01 2010-07-06 IntegenX, Inc. Optimized sample injection structures in microfluidic separations
US20090324574A1 (en) 2006-02-02 2009-12-31 Verenium Corporation Esterases and Related Nucleic Acids and Methods
EP1979079A4 (en) * 2006-02-03 2012-11-28 Integenx Inc MICROFLUIDIC DEVICES
EP2444487B1 (en) 2006-02-10 2018-04-18 BP Corporation North America Inc. Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them
CA2946924A1 (en) 2006-02-14 2007-08-23 Bp Corporation North America Inc. Xylanases, nucleic acids encoding them and methods for making and using them
JPWO2007097443A1 (ja) * 2006-02-20 2009-07-16 国立大学法人 北海道大学 Ｄｎａ塩基配列を決定する方法
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
CN102690833B (zh) 2006-03-07 2015-09-09 巴斯夫酶有限责任公司 醛缩酶、编码它们的核酸及制备和使用它们的方法
ES2416104T3 (es) 2006-03-07 2013-07-30 Cargill, Incorporated Aldolasas, ácidos nucleicos que las codifican y métodos para producir y usar las mismas
US7397546B2 (en) * 2006-03-08 2008-07-08 Helicos Biosciences Corporation Systems and methods for reducing detected intensity non-uniformity in a laser beam
US20080309926A1 (en) * 2006-03-08 2008-12-18 Aaron Weber Systems and methods for reducing detected intensity non uniformity in a laser beam
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US8288157B2 (en) 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US7951583B2 (en) * 2006-03-10 2011-05-31 Plc Diagnostics, Inc. Optical scanning system
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
WO2007106580A2 (en) * 2006-03-15 2007-09-20 Micronics, Inc. Rapid magnetic flow assays
US7766033B2 (en) * 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
MX2008012013A (es) 2006-03-23 2008-10-03 Novartis Ag Tratamiento con anticuerpo antigeno de celulas neoplasicas.
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
ES2692380T3 (es) 2006-03-24 2018-12-03 Handylab, Inc. Método para realizar PCR con un cartucho con varias pistas
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
EP1997888A4 (en) * 2006-03-24 2010-07-28 Toshiba Kk NUCLEIC ACID DETECTION CASSETTE AND NUCLEIC ACID DETERGENT
ITTO20060226A1 (it) 2006-03-27 2007-09-28 Silicon Biosystem S P A Metodo ed apparato per il processamento e o l'analisi e o la selezione di particelle, in particolare particelle biologiche
US20070232556A1 (en) * 2006-03-31 2007-10-04 Montine Thomas J Methods and compositions for the treatment of neurological diseases and disorders
WO2007113838A2 (en) * 2006-04-03 2007-10-11 Given Imaging Ltd. Device, system and method for in-vivo analysis
EP2007433B1 (en) * 2006-04-03 2011-10-26 Given Imaging Ltd. Device, system and method for in-vivo analysis
KR100754399B1 (ko) * 2006-04-05 2007-08-31 삼성전자주식회사 단일 챔버를 이용한 세포 파괴 및 핵산의 정제 방법 및장치
US9862984B2 (en) 2006-04-21 2018-01-09 Nanobiosym, Inc. Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents
US20070260174A1 (en) * 2006-05-05 2007-11-08 Searete Llc Detecting a failure to maintain a regimen
JP2007301534A (ja) * 2006-05-15 2007-11-22 Ebara Corp 微細化装置
US8137626B2 (en) 2006-05-19 2012-03-20 California Institute Of Technology Fluorescence detector, filter device and related methods
WO2008000060A1 (en) * 2006-05-19 2008-01-03 The Governors Of The University Of Alberta Microfluidic methods for nucleic acid monitoring
CA2653321A1 (en) 2006-05-26 2007-12-06 Althea Technologies, Inc. Biochemical analysis of partitioned cells
US7998418B1 (en) 2006-06-01 2011-08-16 Nanotek, Llc Evaporator and concentrator in reactor and loading system
US7641860B2 (en) 2006-06-01 2010-01-05 Nanotek, Llc Modular and reconfigurable multi-stage microreactor cartridge apparatus
GB0611041D0 (en) * 2006-06-05 2006-07-12 Univ Bristol Mixing apparatus and method of designing a mixing apparatus
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
EP2029779A4 (en) 2006-06-14 2010-01-20 Living Microsystems Inc HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
EP2041573B1 (en) * 2006-06-23 2019-09-04 PerkinElmer Health Sciences, Inc. Methods and devices for microfluidic point-of-care immunoassays
US7572618B2 (en) 2006-06-30 2009-08-11 Bristol-Myers Squibb Company Polynucleotides encoding novel PCSK9 variants
US7312029B1 (en) * 2006-06-30 2007-12-25 Searete Llc Method of combing an elongated molecule
US7851028B2 (en) * 2006-06-30 2010-12-14 The Invention Science Fund I, Llc Method of combing an elongated molecule
US7642049B2 (en) 2006-06-30 2010-01-05 Bristol-Myers Squibb Company Method for identifying HIV-1 protease inhibitors with reduced metabolic affects through detection of human resistin polymorphisms
US7618771B2 (en) * 2006-06-30 2009-11-17 Searete Llc Method of combing a nucleic acid
KR100790881B1 (ko) * 2006-07-06 2008-01-02 삼성전자주식회사 미세유체 반응칩 및 이의 제조방법
US7771655B2 (en) * 2006-07-12 2010-08-10 Bayer Healthcare Llc Mechanical device for mixing a fluid sample with a treatment solution
EP2041574B1 (en) 2006-07-14 2016-11-16 The Regents of The University of California Cancer biomarkers and methods of use threof
US20080241951A1 (en) * 2006-07-20 2008-10-02 Visigen Biotechnologies, Inc. Method and apparatus for moving stage detection of single molecular events
US20080241938A1 (en) * 2006-07-20 2008-10-02 Visigen Biotechnologies, Inc. Automated synthesis or sequencing apparatus and method for making and using same
US20080091005A1 (en) * 2006-07-20 2008-04-17 Visigen Biotechnologies, Inc. Modified nucleotides, methods for making and using same
US7858363B2 (en) * 2006-07-22 2010-12-28 Zymo Research Corporation Plasmid DNA isolation
WO2008012550A2 (en) 2006-07-28 2008-01-31 Diagnostics For The Real World, Ltd. Device, system and method for processing a sample
BRPI0714876B1 (pt) 2006-08-04 2022-04-19 Verenium Corporation Ácido nucleico isolado, sintético ou recombinante, cassete de expressão, vetor ou veículo de clonagem, célula bacteriana, fúngica ou de levedura transformada, polipeptídeo isolado, sintético ou recombinante, composição, bem como métodos de produção e de usos dos mesmos
US7854902B2 (en) * 2006-08-23 2010-12-21 Nanotek, Llc Modular and reconfigurable multi-stage high temperature microreactor cartridge apparatus and system for using same
EP2064332B1 (en) * 2006-09-14 2012-07-18 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
WO2008036614A1 (en) * 2006-09-18 2008-03-27 California Institute Of Technology Apparatus for detecting target molecules and related methods
JP2010510964A (ja) 2006-09-19 2010-04-08 アシュラジェン インコーポレイテッド 治療的介入の標的としての、ｍｉＲ−１５、ｍｉＲ−２６、ｍｉＲ−３１、ｍｉＲ−１４５、ｍｉＲ−１４７、ｍｉＲ−１８８、ｍｉＲ−２１５、ｍｉＲ−２１６、ｍｉＲ−３３１、ｍｍｕ−ｍｉＲ−２９２−３ｐによって調節される遺伝子および経路
AU2007299828C1 (en) 2006-09-19 2014-07-17 Interpace Diagnostics, Llc MicroRNAs differentially expressed in pancreatic diseases and uses thereof
EP2617823B1 (en) 2006-09-21 2015-07-01 BASF Enzymes LLC Phytases, nucleic acids encoding them and methods for making and using them
PL2057274T3 (pl) 2006-09-21 2014-05-30 Dsm Ip Assets Bv Fosfolipazy, kodujące je kwasy nukleinowe i sposoby ich wytwarzania i stosowania
US8841116B2 (en) * 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
US8618248B2 (en) 2006-10-31 2013-12-31 President And Fellows Of Harvard College Phosphopeptide compositions and anti-phosphopeptide antibody compositions and methods of detecting phosphorylated peptides
CA2668235A1 (en) 2006-11-02 2008-06-05 Yale University Assessment of oocyte competence
JP2008122234A (ja) * 2006-11-13 2008-05-29 Konica Minolta Medical & Graphic Inc マイクロ総合分析チップおよびマイクロ総合分析システム
US8765076B2 (en) * 2006-11-14 2014-07-01 Handylab, Inc. Microfluidic valve and method of making same
WO2008140568A2 (en) 2006-11-15 2008-11-20 Idaho Technology, Inc. High density self-contained biological analysis
US9102911B2 (en) 2009-05-15 2015-08-11 Biofire Diagnostics, Llc High density self-contained biological analysis
US20100173795A1 (en) * 2006-11-17 2010-07-08 Yale University HIV and Hepatitis C Microarray to Detect Drug Resistance
JP4852399B2 (ja) * 2006-11-22 2012-01-11 富士フイルム株式会社 二液合流装置
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
US20080152543A1 (en) * 2006-11-22 2008-06-26 Hideyuki Karaki Temperature regulation method of microfluidic chip, sample analysis system and microfluidic chip
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
AU2007334393A1 (en) 2006-12-14 2008-06-26 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US7932034B2 (en) 2006-12-20 2011-04-26 The Board Of Trustees Of The Leland Stanford Junior University Heat and pH measurement for sequencing of DNA
WO2008080093A2 (en) 2006-12-21 2008-07-03 Verenium Corporation Amylases and glucoamylases, nucleic acids encoding them and methods for making and using them
CA2673736A1 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
PE20121126A1 (es) * 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
EP1946841A1 (en) * 2006-12-22 2008-07-23 Eppendorf Array Technologies SA Device and/or method for the detection of amplified nucleotides sequences on micro-arrays
EP1935496A1 (en) * 2006-12-22 2008-06-25 Eppendorf Array Technologies SA Device and/or method for the detection of amplified nucleotides sequences on micro-arrays
KR20100019409A (ko) 2007-01-22 2010-02-18 웨이퍼젠, 인크. 고효율 화학 반응을 위한 장치 및 방법
US20090050569A1 (en) * 2007-01-29 2009-02-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
US20080245740A1 (en) * 2007-01-29 2008-10-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
US10001496B2 (en) 2007-01-29 2018-06-19 Gearbox, Llc Systems for allergen detection
CA2674721C (en) 2007-01-30 2018-04-03 Verenium Corporation Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them
CN101715483A (zh) * 2007-02-05 2010-05-26 微芯片生物工艺学股份有限公司 微流体和纳米流体装置、系统和应用
US20110020797A1 (en) * 2007-02-09 2011-01-27 Bristol-Myers Squibb Company Methods For Identifying Patients With An Increased Likelihood Of Responding To DPP-IV Inhibitors
WO2008101196A1 (en) * 2007-02-15 2008-08-21 Osmetech Molecular Diagnostics Fluidics devices
US7867783B2 (en) 2007-02-22 2011-01-11 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US8871471B2 (en) * 2007-02-23 2014-10-28 Ibis Biosciences, Inc. Methods for rapid forensic DNA analysis
US7799656B2 (en) 2007-03-15 2010-09-21 Dalsa Semiconductor Inc. Microchannels for BioMEMS devices
EP1974816A1 (en) * 2007-03-23 2008-10-01 Koninklijke Philips Electronics N.V. Integrated microfluidic device with integrated circuit
EP2129458A2 (en) * 2007-03-23 2009-12-09 Koninklijke Philips Electronics N.V. Integrated microfluidic device with reduced peak power consumption
JP4489088B2 (ja) * 2007-03-23 2010-06-23 株式会社東芝 核酸検出用デバイス
EP1974815A1 (en) * 2007-03-23 2008-10-01 Koninklijke Philips Electronics N.V. Integrated micofluidic device with sensing and control circuits
WO2008118808A1 (en) 2007-03-23 2008-10-02 Advion Bioscience, Inc. Liquid chromatography-mass spectrometry
US20100204266A1 (en) * 2007-03-23 2010-08-12 Ibis Biosciences, INC Compositions for use in identification of mixed populations of bioagents
JP4922808B2 (ja) * 2007-03-30 2012-04-25 富士フイルム株式会社 検体の検出方法及び検出装置
US7863037B1 (en) 2007-04-04 2011-01-04 Maven Technologies, Llc Ligand binding assays on microarrays in closed multiwell plates
US8425861B2 (en) * 2007-04-04 2013-04-23 Netbio, Inc. Methods for rapid multiplexed amplification of target nucleic acids
US20080300798A1 (en) * 2007-04-16 2008-12-04 Mcdevitt John T Cardibioindex/cardibioscore and utility of salivary proteome in cardiovascular diagnostics
US20100129878A1 (en) * 2007-04-25 2010-05-27 Parthasarathy Ranjani V Methods for nucleic acid amplification
US8916745B2 (en) 2007-04-27 2014-12-23 The Regents Of The University Of California Plant CO2 sensors, nucleic acids encoding them, and methods for making and using them
CN103495439B (zh) 2007-05-04 2015-09-16 欧普科诊断有限责任公司 流体连接器和微流体系统
US20090041633A1 (en) * 2007-05-14 2009-02-12 Dultz Shane C Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7799558B1 (en) 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
US20090047191A1 (en) * 2007-06-08 2009-02-19 Gafur Zainiev Closed space disposable micro-reactor and uses thereof
WO2008157480A1 (en) * 2007-06-14 2008-12-24 University Of Rochester Microfluidic device and method of manufacturing the microfluidic device
US9346197B2 (en) 2007-06-14 2016-05-24 University Of Rochester Microfluidic device and method of manufacturing the microfluidic device
US9457497B2 (en) 2007-06-14 2016-10-04 University Of Rochester Microfluidic device and method of manufacturing the microfluidic device
US20090011470A1 (en) * 2007-06-26 2009-01-08 Lakdawalla Abizar A Nucleic acid sample preparation by exclusion of DNA
EP2170922A4 (en) * 2007-06-26 2010-08-11 Life Technologies Corp PREPARATION OF A NUCLEIC ACID SAMPLE BY DNA EXCLUSION
US20090017528A1 (en) * 2007-07-12 2009-01-15 Pei-Tai Chen Nucleic Acid Hybridization Device
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US8133671B2 (en) * 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
ES2648798T3 (es) * 2007-07-13 2018-01-08 Handylab, Inc. Materiales de captura de polinucleótidos y métodos de utilización de los mismos
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8105783B2 (en) * 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US20090136385A1 (en) * 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
BRPI0814423B1 (pt) 2007-07-17 2022-04-19 Plexxikon, Inc Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos
CN105543084B (zh) * 2007-07-23 2019-09-06 美艾利尔技术公司 分析系统
WO2009015296A1 (en) * 2007-07-24 2009-01-29 The Regents Of The University Of California Microfabricated dropley generator
US7507539B2 (en) * 2007-07-30 2009-03-24 Quest Diagnostics Investments Incorporated Substractive single label comparative hybridization
EP2171420A1 (en) 2007-07-31 2010-04-07 Micronics, Inc. Sanitary swab collection system, microfluidic assay device, and methods for diagnostic assays
US20110212491A1 (en) * 2007-08-03 2011-09-01 Enigma Diagnostics Limited Reaction vessel
GB0715170D0 (en) * 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Reaction vessel
ITBO20070588A1 (it) 2007-08-13 2009-02-14 Silicon Biosystems Spa Metodo per legare uno strato di silicone ad un substrato di polimero metacrilico
WO2009024773A1 (en) 2007-08-17 2009-02-26 Diagnostics For The Real World, Ltd Device, system and method for processing a sample
US9234244B2 (en) 2007-08-27 2016-01-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Diagnostic tool for diagnosing benign versus malignant thyroid lesions
US9221056B2 (en) 2007-08-29 2015-12-29 Canon U.S. Life Sciences, Inc. Microfluidic devices with integrated resistive heater electrodes including systems and methods for controlling and measuring the temperatures of such heater electrodes
US10722250B2 (en) 2007-09-04 2020-07-28 Colorado School Of Mines Magnetic-field driven colloidal microbots, methods for forming and using the same
US20090062828A1 (en) * 2007-09-04 2009-03-05 Colorado School Of Mines Magnetic field-based colloidal atherectomy
US8778663B2 (en) * 2007-09-18 2014-07-15 Lawrence Livermore National Security, Llc. Thermal cycler
US8445217B2 (en) 2007-09-20 2013-05-21 Vanderbilt University Free solution measurement of molecular interactions by backscattering interferometry
CN101952437B (zh) 2007-10-03 2014-04-09 维莱尼姆公司 木聚糖酶、编码它们的核酸以及其制备和应用方法
JP5523327B2 (ja) * 2007-10-12 2014-06-18 レオニックス，インコーポレイテッド 統合型マイクロ流体デバイスおよび方法
US7767441B2 (en) * 2007-10-25 2010-08-03 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
US7811810B2 (en) 2007-10-25 2010-10-12 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
ITTO20070771A1 (it) 2007-10-29 2009-04-30 Silicon Biosystems Spa Metodo e apparato per la identificazione e manipolazione di particelle
US8381169B2 (en) * 2007-10-30 2013-02-19 International Business Machines Corporation Extending unified process and method content to include dynamic and collaborative content
EP2212437A4 (en) * 2007-11-07 2011-09-28 Univ British Columbia MICROFLUIDIC DEVICE AND METHOD OF USING THE DEVICE
WO2009076302A1 (en) 2007-12-10 2009-06-18 Bayer Healthcare Llc Control markers for auto-detection of control solution and methods of use
EP2072115A1 (en) * 2007-12-21 2009-06-24 Corning Incorporated Microreactor assembly incorporating an interconnecting element
WO2009088949A1 (en) 2008-01-03 2009-07-16 Verenium Corporation Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
WO2009089189A2 (en) 2008-01-03 2009-07-16 Cellasic Cell culture array system for automated assays and methods of operation and manufacture thereof
DE102008004139B3 (de) * 2008-01-14 2009-06-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung und Verfahren zum Hin- und Herbewegen einer Flüssigkeit über eine vorbestimmte Fläche
US20090209883A1 (en) * 2008-01-17 2009-08-20 Michael Higgins Tissue penetrating apparatus
WO2009092106A1 (en) * 2008-01-18 2009-07-23 The Regents Of The University Of California Accurate and rapid micromixer for integrated microfluidic devices
WO2009108260A2 (en) 2008-01-22 2009-09-03 Microchip Biotechnologies, Inc. Universal sample preparation system and use in an integrated analysis system
EP2245197B1 (en) * 2008-02-07 2016-10-12 Whitespace Enterprise Corporation Improvements in and relating to analysis
EP2255010B1 (en) * 2008-02-20 2018-05-30 Streck Inc. Thermocycler and sample vessel for rapid amplification of dna
CN102084001B (zh) 2008-03-28 2015-03-18 加利福尼亚太平洋生物科学股份有限公司 用于核酸测序的组合物和方法
US8192371B2 (en) * 2008-03-31 2012-06-05 The Invention Science Fund I, Llc Systems and methods for obtaining analytes from a body
EP2107125A1 (en) 2008-03-31 2009-10-07 Eppendorf Array Technologies SA (EAT) Real-time PCR of targets on a micro-array
WO2009126900A1 (en) * 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
WO2009128936A2 (en) 2008-04-16 2009-10-22 The Johns Hopkins University Compositions and methods for treating or preventing prostate cancer and for detecting androgen receptor variants
EP2283163B1 (en) 2008-04-18 2015-07-08 Tufts Medical Center Polymorphisms associated with age-related macular degeneration and methods for evaluating patient risk
EP2285491A1 (en) * 2008-04-25 2011-02-23 Claros Diagnostics, Inc. Flow control in microfluidic systems
US20090269800A1 (en) * 2008-04-29 2009-10-29 Todd Covey Device and method for processing cell samples
US20110118125A1 (en) * 2008-05-03 2011-05-19 Tufts Medical Center, Inc. Neonatal salivary genomics
EP2993239A1 (en) 2008-05-16 2016-03-09 AstraZeneca AB Methods for identifying subjects with an increased likelihood of responding to dpp-iv inhibitors
US8039270B2 (en) * 2008-05-22 2011-10-18 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7981664B1 (en) 2008-05-22 2011-07-19 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
PL2297359T4 (pl) 2008-05-30 2014-07-31 Univ North Carolina Chapel Hill Profile ekspresji genów do przewidywania skutków raka piersi
CA2726811C (en) 2008-06-06 2019-11-26 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Survival predictor for diffuse large b cell lymphoma
GB2461026B (en) 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
US8216526B2 (en) * 2008-06-17 2012-07-10 The United States of America, as represented by the Secretary of Commerce, The National Institute of Standards and Technology Method and device for generating diffusive gradients in a microfluidic chamber
EP2982437B1 (en) 2008-06-25 2017-12-06 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale fet arrays
US20110177976A1 (en) * 2008-06-30 2011-07-21 The Washington University Methods for promoting weight loss and associated arrays
US9183237B2 (en) 2008-07-10 2015-11-10 Nodality, Inc. Methods and apparatus related to gate boundaries within a data space
US20100030719A1 (en) * 2008-07-10 2010-02-04 Covey Todd M Methods and apparatus related to bioinformatics data analysis
GB2474613A (en) * 2008-07-10 2011-04-20 Nodality Inc Methods and apparatus related to management of experiments
US20100014741A1 (en) * 2008-07-10 2010-01-21 Banville Steven C Methods and apparatus related to gate boundaries within a data space
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
US20100009351A1 (en) * 2008-07-11 2010-01-14 Handylab, Inc. Polynucleotide Capture Materials, and Method of Using Same
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US7976789B2 (en) * 2008-07-22 2011-07-12 The Board Of Trustees Of The University Of Illinois Microfluidic device for preparing mixtures
US8357503B2 (en) 2008-08-29 2013-01-22 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
US8153391B2 (en) 2008-08-29 2012-04-10 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
CN102165315B (zh) 2008-08-29 2014-06-18 森托科尔奥索生物科技公司 用于使用20基因群组评估及治疗溃疡性结肠炎和相关疾病的标记物和方法
US8198062B2 (en) 2008-08-29 2012-06-12 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
JP5822726B2 (ja) * 2008-09-03 2015-11-24 クワンタムディーエックス・グループ・リミテッド 電荷量タグを含む合成ヌクレオチドのデザイン、合成及び使用
EP2321429B1 (en) 2008-09-03 2016-08-17 Quantumdx Group Limited Methods and kits for nucleic acid sequencing
US10759824B2 (en) 2008-09-03 2020-09-01 Quantumdx Group Limited Design, synthesis and use of synthetic nucleotides comprising charge mass tags
US8148163B2 (en) 2008-09-16 2012-04-03 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
WO2010033599A2 (en) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Mixing cartridges, mixing stations, and related kits, systems, and methods
EP2344893B1 (en) 2008-09-16 2014-10-15 Ibis Biosciences, Inc. Microplate handling systems and methods
HUE031848T2 (en) 2008-09-20 2017-08-28 Univ Leland Stanford Junior Non-invasive diagnosis of fetal aneuploidy by sequencing
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
WO2011120024A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet generation for droplet-based assays
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US9289765B2 (en) * 2008-09-23 2016-03-22 Samsung Electronics Co., Ltd. Micro-fluidic device and sample testing apparatus using the same
US12162008B2 (en) 2008-09-23 2024-12-10 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US8633015B2 (en) * 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
WO2011120006A1 (en) 2010-03-25 2011-09-29 Auantalife, Inc. A Delaware Corporation Detection system for droplet-based assays
US9598725B2 (en) * 2010-03-02 2017-03-21 Bio-Rad Laboratories, Inc. Emulsion chemistry for encapsulated droplets
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
CN102405402A (zh) 2008-09-23 2012-04-04 阔达生命有限公司 基于液滴的测定系统
US12090480B2 (en) 2008-09-23 2024-09-17 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US9089844B2 (en) 2010-11-01 2015-07-28 Bio-Rad Laboratories, Inc. System for forming emulsions
US9399215B2 (en) 2012-04-13 2016-07-26 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
EP2350673B1 (en) * 2008-10-24 2022-05-11 Leica Biosystems Richmond, Inc. Modular system for performing laboratory protocols and associated methods
US9034257B2 (en) 2008-10-27 2015-05-19 Nodality, Inc. High throughput flow cytometry system and method
JP5632382B2 (ja) * 2008-10-31 2014-11-26 アッヴィ・インコーポレイテッド 遺伝子コピー数変化のパターンに基づいた非小細胞肺癌のゲノム分類
CN102203788B (zh) * 2008-10-31 2015-05-20 Abbvie公司 用于装配成小组的癌细胞系以用于测试一种或多种药物组合物的功效的方法
CN102203787B (zh) * 2008-10-31 2015-08-26 Abbvie公司 基于基因拷贝数改变的模式的结肠直肠癌的基因组分类
EP2359284A2 (en) * 2008-10-31 2011-08-24 Abbott Laboratories Method for genomic classification of malignant melanoma based on patterns of gene copy number alterations
US10895575B2 (en) 2008-11-04 2021-01-19 Menarini Silicon Biosystems S.P.A. Method for identification, selection and analysis of tumour cells
IT1391619B1 (it) 2008-11-04 2012-01-11 Silicon Biosystems Spa Metodo per l'individuazione, selezione e analisi di cellule tumorali
US20120052066A1 (en) 2008-11-07 2012-03-01 Cesar Calderon Markers and methods for assessing and treating lupus patients susceptible to photoprovocation
US8309306B2 (en) * 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
CH699853A1 (de) * 2008-11-13 2010-05-14 Tecan Trading Ag Messgerät und Verfahren zum Bestimmen von durch ein Laborsystem bereitgestellten Fluidparametern.
US8703358B2 (en) * 2008-11-20 2014-04-22 Mti Microfuel Cells, Inc. Fuel cell feed systems
DK2376226T3 (en) 2008-12-18 2018-10-15 Opko Diagnostics Llc IMPROVED REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND PROCEDURES
US8448499B2 (en) 2008-12-23 2013-05-28 C A Casyso Ag Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method
US8672532B2 (en) 2008-12-31 2014-03-18 Integenx Inc. Microfluidic methods
US7927904B2 (en) 2009-01-05 2011-04-19 Dalsa Semiconductor Inc. Method of making BIOMEMS devices
US20100184623A1 (en) * 2009-01-22 2010-07-22 Suz-Kai Hsiung Gene-array operation chip device
US8100293B2 (en) * 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
US9375169B2 (en) * 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
GB0901593D0 (en) 2009-01-30 2009-03-11 Touchlight Genetics Ltd Production of closed linear DNA
DE202010018623U1 (de) 2009-02-02 2018-12-07 Opko Diagnostics, Llc Strukturen zur Steuerung der Lichtwechselwirkung mit mikrofluidischen Vorrichtungen
US8640555B2 (en) * 2009-02-09 2014-02-04 Bioaccel Performance
US8158936B2 (en) 2009-02-12 2012-04-17 Ibis Biosciences, Inc. Ionization probe assemblies
ES2661310T3 (es) * 2009-03-09 2018-03-28 Bioatla, Llc Proteínas mirac
ES2672366T3 (es) * 2009-03-17 2018-06-14 Menarini Silicon Biosystems S.P.A. Dispositivo microfluídico para el aislamiento de celdas
ITBO20090153A1 (it) * 2009-03-17 2010-09-18 Silicon Biosystems Spa Apparato per l'isolamento di particelle
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
WO2010111265A1 (en) 2009-03-24 2010-09-30 University Of Chicago Slip chip device and methods
WO2010111595A2 (en) 2009-03-27 2010-09-30 Tufts - New England Medical Center Markers related to age-related macular degeneration and uses therefor
MX2011008303A (es) 2009-04-03 2011-11-29 Plexxikon Inc Composiciones del acido propano-1-sulfonico {3-[5-(4-cloro-fenil)- 1h-pirrolo [2,3-b]-piridina-3-carbonil]-2,4-difluoro-fenil}-amida y el uso de las mismas.
EP2419204A2 (en) 2009-04-14 2012-02-22 Biocartis SA Hifu induced cavitation with reduced power threshold
EP2419220B1 (en) 2009-04-15 2018-06-06 Biocartis NV Protection of bioanalytical sample chambers
AU2010237532B2 (en) 2009-04-15 2014-11-20 Biocartis Nv Optical detection system for monitoring rtPCR reaction
CA2759396A1 (en) 2009-04-29 2010-11-04 Plc Diagnostics Inc. Waveguide-based detection system with scanning light source
JP5766180B2 (ja) 2009-05-06 2015-08-19 ビオカルティ ナームローゼ フェノーツハップＢｉｏｃａｒｔｉｓ ＮＶ 試料キャリヤを切断するための装置
EP2429704A2 (en) * 2009-05-14 2012-03-21 Streck Inc. Sample processing cassette, system, and method
AU2010249500B2 (en) 2009-05-21 2016-03-24 Basf Enzymes Llc Phytases, nucleic acids encoding them and methods for making and using them
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
US8673627B2 (en) * 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
WO2010141511A2 (en) 2009-06-01 2010-12-09 Halo-Bio Rnai Therapeutics, Inc. Polynucleotides for multivalent rna interference, compositions and methods of use thereof
CN102459565A (zh) 2009-06-02 2012-05-16 尹特根埃克斯有限公司 具有隔膜阀的流控设备
WO2010141131A1 (en) 2009-06-04 2010-12-09 Lockheed Martin Corporation Multiple-sample microfluidic chip for dna analysis
BRPI1010169A2 (pt) 2009-06-05 2016-03-29 Integenx Inc sistema que se ajusta dentro de um invólucro de não mais que 10 pés3, cartucho, artigo em forma legível por computador, método, sistema configurado para realizar um método, sistema óptico, instrumento e dispositivo.
WO2010147654A2 (en) 2009-06-15 2010-12-23 Netbio Inc. Improved methods for forensic dna quantitation
WO2011008971A1 (en) * 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Lift and mount apparatus
WO2011008972A1 (en) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Systems for bioagent identification
US8445201B2 (en) * 2009-07-31 2013-05-21 Affymetrix, Inc. Hybridization device, methods, and system using mixing beads
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
CA3021714C (en) 2009-09-02 2021-03-09 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
CN102906104B (zh) * 2009-09-10 2015-04-22 朗萨生物制剂有限公司 用于多肽纯化的方法和系统
KR20110027419A (ko) * 2009-09-10 2011-03-16 삼성전자주식회사 유체 수용 챔버, 유체 수용 챔버를 구비한 미세 유동 장치, 및 유체 혼합 방법
AU2010298000A1 (en) * 2009-09-25 2012-04-05 Signature Genomics Laboratories Llc Multiplex (+/-) stranded arrays and assays for detecting chromosomal abnormalities associated with cancer and other diseases
US20110091882A1 (en) * 2009-10-02 2011-04-21 Ibis Biosciences, Inc. Determination of methylation status of polynucleotides
WO2011044162A1 (en) 2009-10-06 2011-04-14 Shire Human Genetic Therapies Assays for agents affecting megakaryocyte development
US9890408B2 (en) * 2009-10-15 2018-02-13 Ibis Biosciences, Inc. Multiple displacement amplification
UA111708C2 (uk) 2009-10-16 2016-06-10 Бандж Ойлз, Інк. Спосіб рафінування олії
UA109884C2 (uk) 2009-10-16 2015-10-26 Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування
US20120316080A1 (en) 2009-10-19 2012-12-13 Stichting Het Nederlands Kanker Instiuut Differentiation between brca2-associated tumours and sporadic tumours via array comparative genomic hybridization
WO2011048495A1 (en) 2009-10-19 2011-04-28 Stichting Het Nederlands Kanker Instituut Predicting benefit of anti-cancer therapy via array comparative genomic hybridization
US20120277112A1 (en) 2009-10-19 2012-11-01 Stichting Het Nederlands Kanker Instituut Predicting response to anti-cancer therapy via array comparative genomic hybridization
KR20110046867A (ko) * 2009-10-29 2011-05-06 삼성전자주식회사 기체 제공부를 포함하는 미세 유동 장치, 및 이를 이용한 액체 혼합 방법 및 에멀젼 형성 방법
BR112012012156A2 (pt) 2009-11-06 2015-09-08 Plexxikon Inc compostos e métodos para modulação de cinase, e indicações para esta
USD638951S1 (en) 2009-11-13 2011-05-31 3M Innovative Properties Company Sample processing disk cover
USD667561S1 (en) 2009-11-13 2012-09-18 3M Innovative Properties Company Sample processing disk cover
US20110117607A1 (en) * 2009-11-13 2011-05-19 3M Innovative Properties Company Annular compression systems and methods for sample processing devices
USD638550S1 (en) 2009-11-13 2011-05-24 3M Innovative Properties Company Sample processing disk cover
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
US9229001B2 (en) 2009-11-23 2016-01-05 Cyvek, Inc. Method and apparatus for performing assays
WO2011062557A1 (en) * 2009-11-23 2011-05-26 Haiqing Gong Improved microfluidic device and method
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
WO2013134741A2 (en) 2012-03-08 2013-09-12 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9651568B2 (en) 2009-11-23 2017-05-16 Cyvek, Inc. Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
MX336714B (es) 2009-11-24 2016-01-28 Opko Diagnostics Llc Mezclado y entrega de fluidos en sistemas microfluidicos.
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US8187979B2 (en) * 2009-12-23 2012-05-29 Varian Semiconductor Equipment Associates, Inc. Workpiece patterning with plasma sheath modulation
US8355133B2 (en) 2009-12-30 2013-01-15 Maven Technologies, Llc Biological testing with sawtooth-shaped prisms
US9353342B2 (en) 2010-01-21 2016-05-31 Emd Millipore Corporation Cell culture and gradient migration assay methods and devices
CN102740976B (zh) 2010-01-29 2016-04-20 精密公司 取样-应答微流体盒
JP5691187B2 (ja) * 2010-02-10 2015-04-01 ソニー株式会社 核酸増幅反応用マイクロチップ及びその製造方法
AU2014224115B2 (en) * 2010-02-23 2015-07-09 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
WO2011106315A1 (en) 2010-02-23 2011-09-01 Rheonix, Inc. Self-contained biological assay apparatus, methods, and applications
TWI421340B (zh) * 2010-03-16 2014-01-01 Nat Univ Tsing Hua 微流道晶片及其使用方法
EP2556170A4 (en) 2010-03-25 2014-01-01 Quantalife Inc TRAPPING TRANSPORT AND DETECTION SYSTEM
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
BR112012026406B1 (pt) 2010-04-16 2020-06-09 Opko Diagnostics Llc método de conduzir controle de qualidade para determinar anormalidades na operação de um sistema microfluídico
ITTO20100068U1 (it) * 2010-04-20 2011-10-21 Eltek Spa Dispositivi microfluidici e/o attrezzature per dispositivi microfluidici
EP2564200B8 (en) 2010-04-27 2019-10-02 The Regents of The University of California Cancer biomarkers and methods of use thereof
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
WO2011146725A1 (en) 2010-05-19 2011-11-24 Bayer Healthcare Llc Biomarkers for a multikinase inhibitor
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
NZ604040A (en) 2010-06-03 2015-02-27 Pharmacyclics Inc The use of inhibitors of bruton’s tyrosine kinase (btk)
US9638632B2 (en) 2010-06-11 2017-05-02 Vanderbilt University Multiplexed interferometric detection system and method
US20110312759A1 (en) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Genetic analysis loc with reagent reservoir
TWI580955B (zh) 2010-06-30 2017-05-01 生命技術公司 離子感測電荷累積電路及方法
TW201716791A (zh) 2010-06-30 2017-05-16 生命技術公司 用於測試離子感測場效電晶體（ｉｓｆｅｔ）陣列之裝置及方法
US8415177B2 (en) 2010-06-30 2013-04-09 Life Technologies Corporation Two-transistor pixel array
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
JP5876044B2 (ja) 2010-07-03 2016-03-02 ライフ テクノロジーズ コーポレーション 低濃度ドープドレインを有する化学的感応性センサ
WO2012004723A1 (en) * 2010-07-05 2012-01-12 Koninklijke Philips Electronics N.V. Examination system with sample incubation
EP2409765A1 (en) * 2010-07-21 2012-01-25 F. Hoffmann-La Roche AG Microfluidic system and process for mixing liquid fluids
CN103153466B (zh) * 2010-07-22 2016-04-13 基因细胞生物系统有限公司 复合液体池
EP2754496A3 (en) 2010-07-23 2017-08-02 Beckman Coulter, Inc. System Or Method Of Including Analytical Units
ITBO20100502A1 (it) * 2010-08-04 2012-02-05 Silicon Biosystems Spa Sistema microfluidico
ITBO20100503A1 (it) * 2010-08-04 2012-02-05 Silicon Biosystems Spa Sistema microfluidico
ITBO20100505A1 (it) * 2010-08-04 2012-02-05 Silicon Biosystems Spa Sistema microfluidico
GB201013153D0 (en) 2010-08-04 2010-09-22 Touchlight Genetics Ltd Primer for production of closed linear DNA
ITBO20100504A1 (it) * 2010-08-04 2012-02-05 Silicon Biosystems Spa Sistema microfluidico
EP2606242A4 (en) 2010-08-20 2016-07-20 Integenx Inc MICROFLUIDIC DEVICES WITH MECHANICALLY SEALED MEMBRANE VALVES
WO2012024658A2 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Integrated analysis system
KR101228725B1 (ko) * 2010-09-03 2013-02-01 삼성전기주식회사 미세유체 토출장치 및 이의 제조방법
US9618475B2 (en) 2010-09-15 2017-04-11 Life Technologies Corporation Methods and apparatus for measuring analytes
EP2619326A2 (en) 2010-09-20 2013-07-31 Stichting Het Nederlands Kanker Instituut Methods for predicting response to anti-cancer therapy in cancer patients
EP2619564B1 (en) 2010-09-24 2016-03-16 Life Technologies Corporation Matched pair transistor circuits
US20120077184A1 (en) * 2010-09-28 2012-03-29 Starkdx Incorporated Electromagnetic multiplex assay biosensor
JP2014502144A (ja) 2010-10-06 2014-01-30 ビーピー・コーポレーション・ノース・アメリカ・インコーポレーテッド バリアントｃｂｈｉポリペプチド
WO2012051529A1 (en) 2010-10-15 2012-04-19 Lockheed Martin Corporation Micro fluidic optic design
US8460607B2 (en) 2010-10-22 2013-06-11 Abbott Laboratories Microfluidic device having a flow channel
EP2632494A4 (en) 2010-10-28 2016-04-20 Univ Yale Inc METHOD AND COMPOSITIONS FOR THE STUDY AND TREATMENT OF CANCER
EP2643470B1 (en) 2010-11-24 2016-02-03 Yale University Compositions and methods for treating ischemic injury with d-dt
US10202615B2 (en) 2010-12-10 2019-02-12 Vanderbilt University Mammalian genes involved in toxicity and infection
US9168530B2 (en) 2010-12-17 2015-10-27 Bjs Ip Ltd. Methods and systems for fast PCR heating
IT1403518B1 (it) 2010-12-22 2013-10-31 Silicon Biosystems Spa Dispositivo microfluidico per la manipolazione di particelle
EP2670863B1 (en) 2011-01-31 2018-06-27 H. Hoffnabb-La Roche Ag Methods of identifying multiple epitopes in cells
AU2012214762B2 (en) 2011-02-07 2015-08-13 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US12097495B2 (en) 2011-02-18 2024-09-24 Bio-Rad Laboratories, Inc. Methods and compositions for detecting genetic material
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
AU2012229123B2 (en) 2011-03-15 2017-02-02 British Columbia Cancer Agency Branch Methods of treating breast cancer with anthracycline therapy
CN103534360A (zh) 2011-03-18 2014-01-22 伯乐生命医学产品有限公司 借助对信号的组合使用进行的多重数字分析
CN103649759B (zh) 2011-03-22 2016-08-31 西维克公司 微流体装置以及制造方法和用途
US9051619B2 (en) 2011-03-25 2015-06-09 Florida Agricultural and Mechanical University (FAMU) Methods and compositions for prostate cancer metastasis
US9777332B2 (en) 2011-03-31 2017-10-03 St. Jude Children's Research Hospital Methods and compositions for identifying minimal residual disease in acute lymphoblastic leukemia
US10526572B2 (en) 2011-04-01 2020-01-07 EMD Millipore Corporaticn Cell culture and invasion assay method and system
CA3082652A1 (en) 2011-04-15 2012-10-18 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
AU2012249759A1 (en) 2011-04-25 2013-11-07 Bio-Rad Laboratories, Inc. Methods and compositions for nucleic acid analysis
EP2705130B1 (en) 2011-05-04 2016-07-06 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
US9267112B2 (en) 2011-05-10 2016-02-23 The Regents Of The University Of California Adenovirus isolated from Titi Monkeys
US10221218B2 (en) 2011-05-10 2019-03-05 The Regents Of The University Of California Adenovirus isolated from titi monkeys
EP2707396B1 (en) 2011-05-12 2018-11-14 Gnosis S.p.A. Biotechnological sulphated chondroitin sulphate at position 4 or 6 on the same polysaccharide chain, and process for the preparation thereof
CA2836474A1 (en) 2011-05-17 2012-11-22 Plexxikon Inc. Kinase modulation and indications therefor
BR112013027903B1 (pt) 2011-05-18 2021-01-12 Diasorin S.P.A. estrutura de medição em um dispositivo de processamento de amostras e método para a medição volumétrica de referido dispositivo
USD672467S1 (en) 2011-05-18 2012-12-11 3M Innovative Properties Company Rotatable sample processing disk
CN103501908B (zh) 2011-05-18 2016-03-16 3M创新有限公司 用于样品处理装置上阀调的系统和方法
WO2012158997A1 (en) 2011-05-18 2012-11-22 3M Innovative Properties Company Systems and methods for detecting the presence of a selected volume of material in a sample processing device
UA110717C2 (uk) 2011-05-20 2016-02-10 ГНОЗІС С.п.А. Аналог акулячого хондроїтинсульфату і спосіб його одержання
WO2012166913A1 (en) 2011-06-01 2012-12-06 Streck, Inc. Rapid thermocycler system for rapid amplification of nucleic acids and related methods
KR20120134461A (ko) * 2011-06-02 2012-12-12 삼성전자주식회사 기체 버블 트랩 기능을 갖는 미세 유체 공급소자
WO2013009705A2 (en) 2011-07-09 2013-01-17 The Trustees Of Columbia University In The City Of New York Biomarkers, methods, and compositions for inhibiting a multi-cancer mesenchymal transition mechanism
EP2737089B1 (en) 2011-07-29 2017-09-06 Bio-rad Laboratories, Inc. Library characterization by digital assay
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
CN103959070B (zh) 2011-09-30 2017-05-10 贝克顿·迪金森公司 组合试剂条
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
US20130157884A1 (en) 2011-10-26 2013-06-20 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
EP2771487A1 (en) 2011-10-27 2014-09-03 Asuragen, INC. Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors
ITTO20110990A1 (it) 2011-10-28 2013-04-29 Silicon Biosystems Spa Metodo ed apparato per l'analisi ottica di particelle a basse temperature
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
ES2729283T3 (es) 2011-11-07 2019-10-31 Beckman Coulter Inc Sistema de centrífuga y flujo de trabajo
BR112014011048A2 (pt) 2011-11-07 2017-05-02 Beckman Coulter Inc braço robótico
EP2776847A1 (en) 2011-11-07 2014-09-17 Beckman Coulter, Inc. Magnetic damping for specimen transport system
KR20140091033A (ko) 2011-11-07 2014-07-18 베크만 컬터, 인코포레이티드 검체 컨테이너 검출
BR112014010955A2 (pt) 2011-11-07 2017-06-06 Beckman Coulter Inc sistema e método para processar amostras
EP3373015A1 (en) 2011-11-07 2018-09-12 Beckman Coulter Inc. Aliquotter system and workflow
KR101481054B1 (ko) 2011-11-15 2015-01-14 한국기계연구원 핵산 자동 분석 장치
US8852919B2 (en) * 2011-11-17 2014-10-07 Rheonix, Inc. Microfluidic apparatus, method, and applications
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
EP2785825B1 (en) 2011-12-03 2021-04-21 EMD Millipore Corporation Microfluidic cell culture system
TW201326814A (zh) * 2011-12-21 2013-07-01 Nat Univ Tsing Hua 篩選細胞適合體之微流體晶片裝置及其方法
ITBO20110766A1 (it) 2011-12-28 2013-06-29 Silicon Biosystems Spa Dispositivi, apparato, kit e metodo per il trattamento di un campione biologico
EP2802417B1 (en) 2012-01-09 2019-05-15 Micronics, Inc. Microfluidic reactor system
US8821798B2 (en) 2012-01-19 2014-09-02 Life Technologies Corporation Titanium nitride as sensing layer for microwell structure
US8747748B2 (en) 2012-01-19 2014-06-10 Life Technologies Corporation Chemical sensor with conductive cup-shaped sensor surface
EP3418397B1 (en) 2012-01-24 2020-10-07 CD Diagnostics, Inc. System for detecting infection in synovial fluid
JP5912582B2 (ja) * 2012-01-27 2016-04-27 ローム株式会社 包材入り液体試薬内蔵型マイクロチップおよびその使用方法
ES2978107T3 (es) 2012-02-03 2024-09-05 Becton Dickinson Co Archivos externos para distribución de pruebas de diagnóstico molecular y determinación de compatibilidad entre pruebas
US9637775B2 (en) 2012-02-13 2017-05-02 Neumodx Molecular, Inc. System and method for processing biological samples
US11931740B2 (en) 2012-02-13 2024-03-19 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US9604213B2 (en) 2012-02-13 2017-03-28 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US11485968B2 (en) 2012-02-13 2022-11-01 Neumodx Molecular, Inc. Microfluidic cartridge for processing and detecting nucleic acids
US9101930B2 (en) 2012-02-13 2015-08-11 Neumodx Molecular, Inc. Microfluidic cartridge for processing and detecting nucleic acids
US9322054B2 (en) * 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
CA2863799C (en) 2012-02-22 2020-09-01 Matthew J. FRIGAULT Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer
EP3312749B1 (en) 2012-03-05 2024-05-01 OY Arctic Partners AB Methods and apparatuses for predicting risk of prostate cancer and prostate gland volume
CN104411406B (zh) 2012-03-16 2017-05-31 统计诊断与创新有限公司 具有集成传送模块的测试盒
WO2013154213A1 (en) * 2012-04-10 2013-10-17 Lg Electronics Inc. Diagnostic cartridge
US10132728B2 (en) 2012-04-27 2018-11-20 Cepheid Apparatus with heterogeneous processing modules
US9273949B2 (en) 2012-05-11 2016-03-01 Vanderbilt University Backscattering interferometric methods
IN2014MN02418A (enExample) 2012-05-22 2015-08-14 Nanostring Technologies Inc
WO2013175218A1 (en) 2012-05-24 2013-11-28 Bjs Ip Limited Clamp for fast pcr heating
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
US20130331298A1 (en) * 2012-06-06 2013-12-12 Great Basin Scientific Analyzer and disposable cartridge for molecular in vitro diagnostics
KR20150032340A (ko) 2012-07-24 2015-03-25 파마시클릭스, 인코포레이티드 브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이
JP6525872B2 (ja) 2012-08-08 2019-06-05 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 細胞中の複数のエピトープを同定するためのダイナミックレンジを高めること
WO2014025398A1 (en) 2012-08-10 2014-02-13 Streck, Inc. Real-time optical system for polymerase chain reaction
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
AU2013302756C1 (en) 2012-08-14 2018-05-17 10X Genomics, Inc. Microcapsule compositions and methods
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
WO2014047523A2 (en) 2012-09-21 2014-03-27 California Institute Of Technology Methods and devices for sample lysis
US20140100124A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
CN105008895B (zh) 2012-10-15 2019-02-15 纳诺赛莱克特生物医药股份有限公司 颗粒分选的系统、设备和方法
EP2912174B1 (en) 2012-10-25 2019-06-19 Neumodx Molecular, Inc. Method and materials for isolation of nucleic acid materials
AU2013350823B2 (en) 2012-11-27 2017-11-16 Gencell Biosystems Ltd. Handling liquid samples
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP3567116A1 (en) 2012-12-14 2019-11-13 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP2934751B1 (en) 2012-12-21 2019-05-29 Micronics, Inc. Low elasticity films for microfluidic use
EP2935559B1 (en) 2012-12-21 2020-09-16 PerkinElmer Health Sciences, Inc. Fluorescence detection system
KR102102123B1 (ko) 2012-12-21 2020-04-20 퍼킨엘머 헬스 사이언시즈, 아이엔씨. 유체 공학 회로 및 관련 제조 방법
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
US8962366B2 (en) 2013-01-28 2015-02-24 Life Technologies Corporation Self-aligned well structures for low-noise chemical sensors
BR112015019159A2 (pt) 2013-02-08 2017-07-18 10X Genomics Inc geração de código de barras de polinucleotídeos
US9267171B2 (en) 2013-02-28 2016-02-23 New York University DNA photolithography with cinnamate crosslinkers
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
EP2969156B1 (en) 2013-03-13 2019-04-10 Opko Diagnostics, LLC Mixing of fluids in fluidic systems
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
KR20150127720A (ko) 2013-03-14 2015-11-17 유니버시티 오브 매릴랜드, 발티모어 안드로겐 수용체 하향 조절제 및 그의 용도
JP6671274B2 (ja) 2013-03-15 2020-03-25 ライフ テクノロジーズ コーポレーション 薄伝導性素子を有する化学装置
US9116117B2 (en) 2013-03-15 2015-08-25 Life Technologies Corporation Chemical sensor with sidewall sensor surface
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
US9944992B2 (en) 2013-03-15 2018-04-17 The University Of Chicago Methods and compositions related to T-cell activity
WO2014144209A1 (en) 2013-03-15 2014-09-18 Abbott Molecular Inc. One-step procedure for the purification of nucleic acids
JP6581074B2 (ja) 2013-03-15 2019-09-25 ライフ テクノロジーズ コーポレーション 一貫性のあるセンサ表面積を有する化学センサ
US10234425B2 (en) 2013-03-15 2019-03-19 Qorvo Us, Inc. Thin film bulk acoustic resonator with signal enhancement
JP2016510895A (ja) 2013-03-15 2016-04-11 ライフ テクノロジーズ コーポレーション 一貫性のあるセンサ表面積を有する化学センサ
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
US20140295441A1 (en) * 2013-03-27 2014-10-02 Zygem Corporation Ltd. Cartridge interface module
ES2662110T3 (es) 2013-04-15 2018-04-05 Becton, Dickinson And Company Dispositivo de transferencia de muestras de fluidos biológicos y sistema de separación y de análisis de fluidos biológicos
ES2726188T3 (es) 2013-04-15 2019-10-02 Becton Dickinson Co Dispositivo de toma de muestra de fluido biológico
BR112015026248B1 (pt) 2013-04-15 2022-10-18 Becton, Dickinson And Company Dispositivo de coleta de fluido biológico e sistema de teste e separação de amostra de fluido biológico
JP6267319B2 (ja) 2013-04-15 2018-01-24 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 生物学的流体移送デバイスおよび生物学的流体サンプリングシステム
JP6247380B2 (ja) 2013-04-15 2017-12-13 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 血液採取搬送装置
CA3005826C (en) 2013-04-15 2021-11-23 Becton, Dickinson And Company Biological fluid collection device and biological fluid separation and testing system
JP6174785B2 (ja) 2013-04-15 2017-08-02 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 生物学的流体分離デバイスならびに生物学的流体分離および検査システム
US9517026B2 (en) 2013-04-15 2016-12-13 Becton, Dickinson And Company Biological fluid collection device and biological fluid separation and testing system
ES2958415T3 (es) 2013-04-15 2024-02-08 Becton Dickinson Co Dispositivo de separación de fluidos biológicos y sistema de separación y análisis de fluidos biológicos
ES2748062T3 (es) 2013-04-15 2020-03-12 Becton Dickinson Co Dispositivo de transferencia de muestreo de fluido biológico y sistema de separación y ensayo de fluido biológico
EP2986216B1 (en) 2013-04-15 2017-11-22 Becton, Dickinson and Company Medical device for collection of a biological sample
BR112015026252B1 (pt) 2013-04-15 2022-03-22 Becton, Dickinson And Company Dispositivo de coleta de fluido biológico e sistema de coleta e teste de fluido biológico
EP2986382B1 (en) 2013-04-15 2024-12-04 Becton, Dickinson and Company Blood sampling transfer and blood separation device
WO2014172661A1 (en) 2013-04-19 2014-10-23 The Regent Of The University Of California Lone star virus
CN105189750B (zh) 2013-05-07 2020-07-28 珀金埃尔默健康科学有限公司 使用粘土矿物和碱性溶液制备含核酸样品的方法
JP6484222B2 (ja) 2013-05-07 2019-03-13 マイクロニクス， インコーポレイテッド 核酸の調製および分析のためのデバイス
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
US20170153253A9 (en) 2013-05-23 2017-06-01 Qorvo Us, Inc. Two part assembly
WO2014190292A1 (en) 2013-05-23 2014-11-27 Rapid Diagnostek Sensors, methods of making and devices
US20160107159A1 (en) * 2013-05-27 2016-04-21 Star Array Pte Ltd Microfluidic device and method for controlling fluid flow thereinto
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
EP3014251A1 (en) 2013-06-28 2016-05-04 Streck Inc. Devices for real-time polymerase chain reaction
WO2014207258A1 (en) 2013-06-28 2014-12-31 Danmarks Tekniske Universitet A microfluidic device with a diffusion barrier
US20160136642A1 (en) 2013-06-28 2016-05-19 Danmarks Tekniske Universitet A Microfluidic Device with Pillars
WO2015023710A1 (en) 2013-08-12 2015-02-19 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
AU2014317843A1 (en) 2013-09-09 2016-03-24 British Columbia Cancer Agency Branch Methods and kits for predicting outcome and methods and kits for treating breast cancer with radiation therapy
ITMI20131541A1 (it) 2013-09-19 2015-03-20 Eugenio Iannone Dispositivo di diagnosi, particolarmente del tipo lab-on-chip.
WO2015066625A1 (en) 2013-11-01 2015-05-07 Washington University Methods to establish and restore normal gut microbiota function of subject in need thereof
ES2923942T3 (es) 2013-11-06 2022-10-03 Us Health Procedimiento para el subtipado de tipos de linfoma por medio de perfiles de expresión
WO2015073999A1 (en) 2013-11-18 2015-05-21 Integenx Inc. Cartridges and instruments for sample analysis
US9824068B2 (en) 2013-12-16 2017-11-21 10X Genomics, Inc. Methods and apparatus for sorting data
EP3105326A4 (en) 2014-02-10 2018-01-10 Gencell Biosystems Limited Composite liquid cell (clc) mediated nucleic acid library preparation device, and methods for using the same
KR20150101316A (ko) * 2014-02-26 2015-09-03 삼성전자주식회사 유체 분석 카트리지
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
US10195610B2 (en) 2014-03-10 2019-02-05 Click Diagnostics, Inc. Cartridge-based thermocycler
JP2017509336A (ja) 2014-03-20 2017-04-06 ファーマサイクリックス エルエルシー ホスホリパーゼｃガンマ２及び耐性に関連した変異
DE102014205728B3 (de) 2014-03-27 2015-03-05 Robert Bosch Gmbh Chiplabor-Kartusche für ein mikrofluidisches System zum Analysieren einer Probe biologischen Materials, mikrofluidisches System zum Analysieren einer Probe biologischen Materials sowie Verfahren und Vorrichtung zum Analysieren einer Probe biologischen Materials
JP2015188377A (ja) * 2014-03-28 2015-11-02 セイコーエプソン株式会社 核酸増幅反応用カートリッジ及び核酸増幅装置
CN106413896B (zh) 2014-04-10 2019-07-05 10X基因组学有限公司 用于封装和分割试剂的流体装置、系统和方法及其应用
DE102014221616A1 (de) * 2014-04-25 2015-10-29 Robert Bosch Gmbh Mikrofluidische Vorrichtung sowie Verfahren zum Analysieren einer Probe biologischen Materials
CA2947605A1 (en) 2014-05-13 2015-11-19 Bioatla, Llc Conditionally active biological proteins
US10774387B2 (en) 2014-05-19 2020-09-15 The Johns Hopkins University Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
EP3149209B1 (en) 2014-05-30 2021-02-17 Genecentric Therapeutics, Inc. Methods for typing of lung cancer
EP3151965B1 (en) 2014-06-04 2021-02-24 Edan Instruments, Inc. Sample collection and analysis devices
US10391425B2 (en) 2014-06-16 2019-08-27 Siemens Healthcare Diagnostics Inc. Fluidic device and degassing method
EP3825411A1 (en) 2014-06-18 2021-05-26 Clear Gene, Inc. Methods, compositions, and devices for rapid analysis of biological markers
CN113249435B (zh) 2014-06-26 2024-09-03 10X基因组学有限公司 分析来自单个细胞或细胞群体的核酸的方法
SG11201610691QA (en) 2014-06-26 2017-01-27 10X Genomics Inc Processes and systems for nucleic acid sequence assembly
JP2017522866A (ja) 2014-06-26 2017-08-17 １０エックス ジェノミクス， インコーポレイテッド 核酸配列の分析
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
CA2956723C (en) 2014-08-12 2023-04-11 Nextgen Jane, Inc. System and method for monitoring health based on collected bodily fluid
CA2959336A1 (en) 2014-08-25 2016-03-03 The Johns Hopkins University Methods and compositions related to prostate cancer therapeutics
EP3186284B1 (en) 2014-08-28 2022-04-06 BioAtla, Inc. Conditionally active chimeric antigen receptors for modified t-cells
US10513699B2 (en) 2014-09-03 2019-12-24 Bioatla, Llc Discovering and producing conditionally active biologic proteins in the same eukaryotic cell production hosts
GB201415789D0 (en) 2014-09-05 2014-10-22 Touchlight Genetics Ltd Synthesis of DNA
ES2860938T3 (es) * 2014-09-25 2021-10-05 European Molecular Biology Laboratory Dispositivo microfluídico para la generación de muestras combinatorias
US10539579B2 (en) 2014-09-29 2020-01-21 C A Casyso Gmbh Blood testing system and method
CN107106983B (zh) 2014-10-22 2021-04-16 尹特根埃克斯有限公司 用于样品制备、处理和分析的系统和方法
US20160122817A1 (en) 2014-10-29 2016-05-05 10X Genomics, Inc. Methods and compositions for targeted nucleic acid sequencing
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
EP3227687A4 (en) 2014-12-05 2018-10-24 Prelude, Inc. Dcis recurrence and invasive breast cancer
BR112017011395B1 (pt) * 2014-12-09 2020-12-08 Po-Kang Lin Dispositivo fotossintetico, e, metodo para provocar fotossintese
US10279345B2 (en) 2014-12-12 2019-05-07 Opko Diagnostics, Llc Fluidic systems comprising an incubation channel, including fluidic systems formed by molding
TWI794007B (zh) 2014-12-18 2023-02-21 美商生命技術公司 積體電路裝置、感測器裝置及積體電路
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
KR20170097712A (ko) 2014-12-18 2017-08-28 라이프 테크놀로지스 코포레이션 대형 fet 어레이를 사용한 분석물 측정을 위한 방법과 장치
AU2015373998A1 (en) 2014-12-31 2017-06-29 Visby Medical, Inc. Devices and methods for molecular diagnostic testing
SG11201705615UA (en) 2015-01-12 2017-08-30 10X Genomics Inc Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
MX2017008916A (es) 2015-01-13 2017-10-19 10X Genomics Inc Sistemas y metodos para visualizar informacion de fases y variaciones estructurales.
US10450594B2 (en) * 2015-01-22 2019-10-22 Po-Kang Lin Photosynthetic device with microfluid chamber for causing photosynthesis therein and method thereof
JP2018506715A (ja) 2015-01-23 2018-03-08 ヴァンダービルト ユニバーシティー 堅固なインターフェロメーター及びその使用方法
WO2016123185A2 (en) * 2015-01-28 2016-08-04 Opti Medicalsystems, Inc. Cartridges, analyzers, and systems for analyzing samples
WO2016122598A1 (en) * 2015-01-30 2016-08-04 Hewlett-Packard Development Company, L.P. Diagnostic chip
CN107208156B (zh) 2015-02-09 2021-10-08 10X基因组学有限公司 用于使用变异识别数据来确定结构变异和定相的系统和方法
WO2016134342A1 (en) 2015-02-20 2016-08-25 Wafergen, Inc. Method for rapid accurate dispensing, visualization and analysis of single cells
CN115651972A (zh) 2015-02-24 2023-01-31 10X 基因组学有限公司 用于靶向核酸序列覆盖的方法
US10697000B2 (en) 2015-02-24 2020-06-30 10X Genomics, Inc. Partition processing methods and systems
KR102790523B1 (ko) 2015-02-24 2025-04-02 바이오아트라, 인코퍼레이티드 조건부 활성 생체 단백질
US11181479B2 (en) 2015-02-27 2021-11-23 Ldip, Llc Waveguide-based detection system with scanning light source
US10160755B2 (en) 2015-04-08 2018-12-25 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
TWI582240B (zh) 2015-05-19 2017-05-11 鄭鴻鈞 以基因體預後評估試劑組預測乳癌患者局部區域復發風險及放射治療有效性的方法、用途及裝置
JPWO2016199437A1 (ja) * 2015-06-12 2018-03-29 株式会社ソシオネクスト 半導体装置
US10233491B2 (en) 2015-06-19 2019-03-19 IntegenX, Inc. Valved cartridge and system
US10775370B2 (en) * 2015-07-17 2020-09-15 Stat-Diagnostica & Innovation, S.L. Fluidic system for performing assays
US10894980B2 (en) 2015-07-17 2021-01-19 President And Fellows Of Harvard College Methods of amplifying nucleic acid sequences mediated by transposase/transposon DNA complexes
US10829484B2 (en) 2015-07-28 2020-11-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
WO2017023929A1 (en) 2015-08-04 2017-02-09 Cd Diagnostics, Inc. Methods for detecting adverse local tissue reaction (altr) necrosis
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
WO2017035278A1 (en) 2015-08-24 2017-03-02 Halo-Bio Rnai Therapeutics, Inc. Polynucleotide nanoparticles for the modulation of gene expression and uses thereof
EP4026616B1 (en) * 2015-08-26 2024-12-11 Emulate, Inc. Perfusion manifold assembly
US11740248B2 (en) 2015-09-23 2023-08-29 Oklahoma Medical Research Foundation Biomarkers for assessing subjects with multiple sclerosis
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
CN115369161A (zh) 2015-12-04 2022-11-22 10X 基因组学有限公司 用于核酸分析的方法和组合物
MX2018006856A (es) 2015-12-07 2018-08-01 Plexxikon Inc Compuestos y metodos para modulacion de la quinasa, e indicaciones de los mismos.
US10852310B2 (en) 2015-12-11 2020-12-01 Opko Diagnostics, Llc Fluidic systems involving incubation of samples and/or reagents
US11401558B2 (en) 2015-12-18 2022-08-02 Clear Gene, Inc. Methods, compositions, kits and devices for rapid analysis of biological markers
JP2019503174A (ja) 2016-01-04 2019-02-07 クァンタムディーエックス グループ リミテッドＱｕａｎｔｕｍｄｘ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ 電荷量タグを含む合成ヌクレオチドのデザイン、合成、および使用
EP3408649B1 (en) 2016-01-29 2023-06-14 Vanderbilt University Free-solution response function interferometry
US10876088B2 (en) 2016-02-04 2020-12-29 Massachusetts Institute Of Technology Modular organ microphysiological system with integrated pumping, leveling, and sensing
US11081208B2 (en) 2016-02-11 2021-08-03 10X Genomics, Inc. Systems, methods, and media for de novo assembly of whole genome sequence data
CN108431577A (zh) * 2016-02-27 2018-08-21 惠普发展公司，有限责任合伙企业 样品制备系统
US9659838B1 (en) * 2016-03-28 2017-05-23 Lockheed Martin Corporation Integration of chip level micro-fluidic cooling in chip packages for heat flux removal
EP3442706B1 (en) 2016-04-13 2025-07-23 NextGen Jane, Inc. Sample collection and preservation methods
WO2017184861A1 (en) 2016-04-20 2017-10-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Evaluation of mantle cell lymphoma and methods related thereto
US10987674B2 (en) 2016-04-22 2021-04-27 Visby Medical, Inc. Printed circuit board heater for an amplification module
WO2017197040A1 (en) 2016-05-11 2017-11-16 Click Diagnostics, Inc. Devices and methods for nucleic acid extraction
WO2017197343A2 (en) 2016-05-12 2017-11-16 10X Genomics, Inc. Microfluidic on-chip filters
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
CA3024744A1 (en) 2016-05-17 2017-11-23 Genecentric Therapeutics, Inc. Methods for subtyping of lung squamous cell carcinoma
US10934595B2 (en) 2016-05-17 2021-03-02 Genecentric Therapeutics, Inc. Methods for subtyping of lung adenocarcinoma
EP3260552A1 (en) 2016-06-20 2017-12-27 Istituto Europeo di Oncologia (IEO) Methods and kits comprising gene signatures for stratifying breast cancer patients
USD800331S1 (en) 2016-06-29 2017-10-17 Click Diagnostics, Inc. Molecular diagnostic device
EP3478857A1 (en) 2016-06-29 2019-05-08 Click Diagnostics, Inc. Devices and methods for the detection of molecules using a flow cell
USD800914S1 (en) 2016-06-30 2017-10-24 Click Diagnostics, Inc. Status indicator for molecular diagnostic device
USD800913S1 (en) 2016-06-30 2017-10-24 Click Diagnostics, Inc. Detection window for molecular diagnostic device
CN109070044B (zh) 2016-07-21 2021-07-30 宝生物工程（美国)有限公司 使用多孔装置进行的多z平面成像和分配
WO2018032043A1 (en) * 2016-08-15 2018-02-22 University Of Tasmania Inorganic ion detection system and methods
US11713486B2 (en) 2016-09-15 2023-08-01 The Regents Of The University Of California Biomarkers for bipolar disorder and schizophrenia
TW201815766A (zh) 2016-09-22 2018-05-01 美商普雷辛肯公司 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症
GB2555003B (en) 2016-09-23 2022-07-06 Blue White Ind Ltd Flow sensor devices and systems
CN109982778A (zh) * 2016-09-23 2019-07-05 阿谢尔德克斯有限公司 流体系统及相关方法
WO2018098241A1 (en) 2016-11-22 2018-05-31 University Of Rochester Methods of assessing risk of recurrent prostate cancer
EP3551047A1 (en) * 2016-12-07 2019-10-16 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
US10427162B2 (en) 2016-12-21 2019-10-01 Quandx Inc. Systems and methods for molecular diagnostics
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA3047580A1 (en) 2016-12-23 2018-07-26 Plexxikon Inc. Compounds and methods for cdk8 modulation and indications therefor
GB201700340D0 (en) 2017-01-09 2017-02-22 Gsg Tech Ltd fluid manipulation cartridge and controller mechanism
EP4029939B1 (en) 2017-01-30 2023-06-28 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
US12264411B2 (en) 2017-01-30 2025-04-01 10X Genomics, Inc. Methods and systems for analysis
US11982611B2 (en) 2017-03-20 2024-05-14 Nanocellect Biomedical, Inc. Systems, apparatuses, and methods for cell sorting and flow cytometry
EP3622291A4 (en) 2017-05-10 2021-04-21 Rowan University Diagnostic biomarkers for detecting, subtyping, and/or assessing progression of multiple sclerosis
US11484543B2 (en) 2017-05-18 2022-11-01 The Rockefeller University Compositions and methods for diagnosing and treating diseases and disorders associated with mutant KCNJ5
EP3625715A4 (en) 2017-05-19 2021-03-17 10X Genomics, Inc. DATA SET ANALYSIS SYSTEMS AND METHODS
SG11201901822QA (en) 2017-05-26 2019-03-28 10X Genomics Inc Single cell analysis of transposase accessible chromatin
US10844372B2 (en) 2017-05-26 2020-11-24 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
US11602750B2 (en) 2017-05-30 2023-03-14 Roche Molecular Systems, Inc. Customizable sample processing device
US10428067B2 (en) 2017-06-07 2019-10-01 Plexxikon Inc. Compounds and methods for kinase modulation
CA3066247A1 (en) 2017-06-07 2018-12-13 University Of Maryland, Baltimore County Factory-on-a-chip for production of biologically derived medicines/biopharmaceuticals/biologics/ biotherapeutics
EP3638814B8 (en) 2017-06-14 2023-06-21 The United States of America, as Represented by The Secretary, Department of Health and Human Services Method for determining lymphoma type
US12275994B2 (en) 2017-06-22 2025-04-15 Clear Gene, Inc. Methods and compositions for the analysis of cancer biomarkers
WO2019018764A1 (en) 2017-07-21 2019-01-24 Genecentric Therapeutics, Inc. METHODS OF DETERMINING RESPONSE TO PARP INHIBITORS
WO2019032525A1 (en) 2017-08-07 2019-02-14 Genecentric Therapeutics, Inc. PROCESS FOR SUBTYPING EPIDERMOID CARCINOMA OF HEAD AND NECK
DE102017218117A1 (de) * 2017-10-11 2019-04-11 Robert Bosch Gmbh Mikrofluidische Vorrichtung, Verfahren zu deren Herstellung und Spritzprägevorrichtung
WO2019084351A1 (en) 2017-10-27 2019-05-02 The Regents Of The University Of California SALIVARY EXTRACELLULAR RNA BIOMARKERS FOR GINGIVITIS
JP7239568B2 (ja) 2017-11-09 2023-03-14 ビスビュー メディカル，インコーポレイテッド 携帯型分子診断デバイスおよび標的ウイルスの検出方法
EP3954782A1 (en) 2017-11-15 2022-02-16 10X Genomics, Inc. Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
EP3727805B1 (en) 2017-12-19 2023-09-13 F. Hoffmann-La Roche AG Sealing press and method of making a frangible seal in a sample processing device
US12195805B2 (en) 2018-02-13 2025-01-14 Genecentric Therapeutics, Inc. Methods for subtyping of bladder cancer
US12065635B2 (en) 2018-03-19 2024-08-20 Massachusetts Institute Of Technology Organ-on-chip platforms with reduced fluid volume
US10046322B1 (en) * 2018-03-22 2018-08-14 Talis Biomedical Corporation Reaction well for assay device
EP3775271B1 (en) 2018-04-06 2025-03-12 10X Genomics, Inc. Systems and methods for quality control in single cell processing
US11752500B2 (en) 2018-04-27 2023-09-12 Corning Incorporated Microfluidic devices and methods for manufacturing microfluidic devices
DE102018210069A1 (de) * 2018-06-21 2019-12-24 Robert Bosch Gmbh Mikrofluidische Vorrichtung, Verfahren zu deren Herstellung und Verwendung
WO2020010293A1 (en) 2018-07-06 2020-01-09 Qorvo Us, Inc. Bulk acoustic wave resonator with increased dynamic range
WO2020032970A1 (en) * 2018-08-10 2020-02-13 Hewlett-Packard Development Company, L.P. Serial cellular analytics
WO2020036869A1 (en) 2018-08-16 2020-02-20 Emd Millipore Corporation Closed bioprocessing device
AU2019337088A1 (en) 2018-09-03 2021-05-06 Visby Medical, Inc. Devices and methods for antibiotic susceptibility testing
WO2020056338A1 (en) 2018-09-14 2020-03-19 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
CA3113526A1 (en) 2018-09-20 2020-03-26 Cepheid System, device and methods of sample processing using semiconductor detection chips
WO2020076897A1 (en) 2018-10-09 2020-04-16 Genecentric Therapeutics, Inc. Detecting cancer cell of origin
CN113166805B (zh) 2018-12-04 2024-07-16 加利福尼亚太平洋生物科学股份有限公司 用于核酸测序和其他分析测定的混合相流体
CA3123229A1 (en) 2018-12-14 2020-06-18 Cepheid Diagnostic detection chip devices and methods of manufacture and assembly
WO2020136602A1 (en) * 2018-12-27 2020-07-02 3M Innovative Properties Company A multilayer test pack for sterilization monitoring
JP2022530323A (ja) 2019-04-28 2022-06-29 ビスビュー メディカル，インコーポレイテッド デジタル検出能力および無線接続性を有する分子診断デバイス
US11639863B2 (en) * 2019-06-07 2023-05-02 Blue-White Industries, Ltd. Flow sensor devices and systems
CN114207448A (zh) 2019-06-07 2022-03-18 蜂巢生物技术公司 用于收集、储存和分析生物样品的细胞盒
WO2021030271A2 (en) 2019-08-09 2021-02-18 Nutcracker Therapeutics, Inc. Methods and apparatuses for manufacturing for removing material from a therapeutic composition
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
DE112020004718T5 (de) * 2019-10-01 2022-07-21 Elemental Scientific, Inc. Automatisierte Inline-Aufbereitung und Entgasung flüchtiger Proben zur Inline-Analyse
US11352675B2 (en) 2020-01-03 2022-06-07 Visby Medical, Inc. Devices and methods for antibiotic susceptability testing
WO2021163630A1 (en) 2020-02-13 2021-08-19 10X Genomics, Inc. Systems and methods for joint interactive visualization of gene expression and dna chromatin accessibility
WO2021222084A1 (en) 2020-04-28 2021-11-04 Siemens Healthcare Diagnostics Inc. Acoustophoretic lysis devices and methods
EP3907301A1 (en) 2020-05-08 2021-11-10 Istituto Europeo di Oncologia S.r.l. Methods and kits for determining the risk of breast cancer recurrence
US20240002957A1 (en) * 2020-05-14 2024-01-04 Technion Research And Development Foundation Ltd. Device, systems, kits and methods for rapid and simple detection of pathogens
US11964278B2 (en) * 2020-09-08 2024-04-23 Dartmouth Ocean Technologies Inc. Microfluidic chip, systems, and methods for capturing of environmental DNA
AU2021340897B2 (en) 2020-09-14 2023-05-25 Enquyst Technologies Inc. Process technology for biological product manufacturing and downstream purification
WO2022226599A1 (en) * 2021-04-30 2022-11-03 University Of Tasmania Sample transfer method and system
USD1064314S1 (en) 2021-08-13 2025-02-25 Visby Medical, Inc. Molecular diagnostic device
EP4453261A1 (en) 2021-12-22 2024-10-30 Cornell University Prognostic/predictive epigenetic breast cancer signature
DE102022208510A1 (de) * 2022-08-17 2024-02-22 Cellcentric Gmbh & Co. Kg Vorrichtung für die Herstellung einer kontaminationsfreien Dispersion

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3631654A (en) * 1968-10-03 1972-01-04 Pall Corp Gas purge device
US3614856A (en) * 1968-11-29 1971-10-26 Perkin Elmer Corp Gas transfer device
FR2106918A5 (enExample) * 1970-09-29 1972-05-05 Rhone Poulenc Sa
US4426451A (en) * 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
CA1238900A (en) * 1982-11-15 1988-07-05 Stephen Saros Single channel continuous slug flow mixing of discrete fluid components
US4490216A (en) 1983-02-03 1984-12-25 Molecular Devices Corporation Lipid membrane electroanalytical elements and method of analysis therewith
US5500188A (en) 1984-03-01 1996-03-19 Molecular Devices Corporation Device for photoresponsive detection and discrimination
US4591550A (en) 1984-03-01 1986-05-27 Molecular Devices Corporation Device having photoresponsive electrode for determining analytes including ligands and antibodies
US4849330A (en) 1984-04-27 1989-07-18 Molecular Devices Corporation Photoresponsive redox detection and discrimination
US4883579A (en) 1984-04-27 1989-11-28 Molecular Devices Corporation Photoresponsive redox detection and discrimination
US4704353A (en) 1984-04-27 1987-11-03 Molecular Devices Corporation Photoresponsive redox detection and discrimination
US4676274A (en) * 1985-02-28 1987-06-30 Brown James F Capillary flow control
EP0213825A3 (en) 1985-08-22 1989-04-26 Molecular Devices Corporation Multiple chemically modulated capacitance
US4790640A (en) 1985-10-11 1988-12-13 Nason Frederic L Laboratory slide
US4789628A (en) 1986-06-16 1988-12-06 Vxr, Inc. Devices for carrying out ligand/anti-ligand assays, methods of using such devices and diagnostic reagents and kits incorporating such devices
US4911794A (en) 1986-06-20 1990-03-27 Molecular Devices Corporation Measuring with zero volume cell
US4915812A (en) * 1986-06-20 1990-04-10 Molecular Devices Corporation Zero volume cell
US4758786A (en) 1986-08-06 1988-07-19 Molecular Devices Corporation Method of analyzing semiconductor systems
US4963815A (en) 1987-07-10 1990-10-16 Molecular Devices Corporation Photoresponsive electrode for determination of redox potential
US4946795A (en) * 1987-08-27 1990-08-07 Biotrack, Inc. Apparatus and method for dilution and mixing of liquid samples
US4858883A (en) * 1987-12-11 1989-08-22 Integrated Fluidics, Inc. Valve with flexible sheet member
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5252294A (en) * 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
US5281516A (en) * 1988-08-02 1994-01-25 Gene Tec Corporation Temperature control apparatus and method
US5188963A (en) * 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
US5382511A (en) * 1988-08-02 1995-01-17 Gene Tec Corporation Method for studying nucleic acids within immobilized specimens
EP0394406B1 (en) 1988-10-21 1995-04-26 Molecular Devices Corporation Methods and apparatus for detecting the effect of cell affecting agents on living cells
SE462408B (sv) * 1988-11-10 1990-06-18 Pharmacia Ab Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet
US5229297A (en) 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
US5871928A (en) * 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5424186A (en) * 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5346672A (en) * 1989-11-17 1994-09-13 Gene Tec Corporation Devices for containing biological specimens for thermal processing
US5171132A (en) * 1989-12-27 1992-12-15 Seiko Epson Corporation Two-valve thin plate micropump
US5126022A (en) * 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US5053060A (en) * 1990-06-29 1991-10-01 Molecular Devices Corporation Device and method for degassing, gassing and debubbling liquids
EP0491026B1 (en) * 1990-07-10 1995-03-01 Westonbridge International Limited Valve, method for producing said valve and micropump incorporating said valve
EP0498863B1 (en) * 1990-08-31 1995-07-26 Westonbridge International Limited A valve equipped with a position detector and a micropump incorporating said valve
AU667293B2 (en) * 1990-10-11 1996-03-21 Indiana University Research And Technology Corporation Process and apparatus for fragmenting biomaterials
DE69132531T2 (de) * 1990-12-06 2001-09-13 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Verbindungen und ihre Verwendung in einer binären Synthesestrategie
US5230866A (en) * 1991-03-01 1993-07-27 Biotrack, Inc. Capillary stop-flow junction having improved stability against accidental fluid flow
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5384261A (en) * 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
AU675054B2 (en) * 1991-11-22 1997-01-23 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US5486335A (en) * 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
AU677780B2 (en) * 1992-05-01 1997-05-08 Trustees Of The University Of Pennsylvania, The Microfabricated detection structures
US5296375A (en) * 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
DE4220077A1 (de) * 1992-06-19 1993-12-23 Bosch Gmbh Robert Mikropumpe
WO1994003791A1 (en) 1992-07-31 1994-02-17 Molecular Devices Corporation Metabolic monitoring of cells in a microplate reader
US5639423A (en) * 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
WO1994011489A1 (en) * 1992-11-06 1994-05-26 Biolog, Inc. Testing device for liquid and liquid suspended samples
US5503980A (en) * 1992-11-06 1996-04-02 Trustees Of Boston University Positional sequencing by hybridization
US5503985A (en) * 1993-02-18 1996-04-02 Cathey; Cheryl A. Disposable device for diagnostic assays
AU6360994A (en) 1993-03-08 1994-09-26 Steven H Boyd Aligned fiber diagnostic chromatography
SE501713C2 (sv) * 1993-09-06 1995-05-02 Pharmacia Biosensor Ab Ventil av membrantyp, speciellt för vätskehanteringsblock med mikroflödeskanaler
CA2174140C (en) 1993-10-28 2004-04-06 Kenneth L. Beattie Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
US5580523A (en) 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5707799A (en) 1994-09-30 1998-01-13 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6130098A (en) * 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US5863801A (en) 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
US5976336A (en) 1997-04-25 1999-11-02 Caliper Technologies Corp. Microfluidic devices incorporating improved channel geometries
AU734957B2 (en) 1997-05-16 2001-06-28 Alberta Research Council Inc. Microfluidic system and methods of use
US6001231A (en) 1997-07-15 1999-12-14 Caliper Technologies Corp. Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems
JPH11137907A (ja) * 1997-11-11 1999-05-25 Moore Kk 脱気装置

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003516762A (ja) * 1999-12-17 2003-05-20 ベーイーオー・メリュー リボ核酸を標識する方法、及びそれにより得られた標識化ｒｎａ断片
WO2003052427A1 (en) * 2001-12-14 2003-06-26 Arkray, Inc. Sample measuring device
US8318109B2 (en) 2003-01-14 2012-11-27 Micronics, Inc. Microfluidic devices for fluid manipulation and analysis
US8697009B2 (en) 2003-01-14 2014-04-15 Micronics, Inc. Microfluidic devices for fluid manipulation and analysis
US8557198B2 (en) 2003-01-14 2013-10-15 Micronics, Inc. Microfluidic devices for fluid manipulation and analysis
US7988913B2 (en) 2003-03-31 2011-08-02 Canon Kabushiki Kaisha Biochemical reaction cartridge
US7754476B2 (en) 2004-02-13 2010-07-13 Canon Kabushiki Kaisha Biochemical reaction cartridge
US8178056B2 (en) 2004-11-02 2012-05-15 Canon Kabushiki Kaisha Biochemical reaction cartridge and biochemical treatment equipment system
US8831783B2 (en) 2004-12-13 2014-09-09 Canon Kabushiki Kaisha Biochemical processing apparatus
US8025853B2 (en) 2004-12-13 2011-09-27 Canon Kabushiki Kaisha Biochemical processing apparatus
US7598064B2 (en) 2004-12-17 2009-10-06 Samsung Electronics Co., Ltd. Microfluidic device comprising electrolysis device for cell lysis and method for electrochemically lysing cells using the same
US8249681B2 (en) 2005-01-31 2012-08-21 Given Imaging Ltd. Device, system and method for in vivo analysis
WO2006092959A1 (ja) * 2005-03-01 2006-09-08 Rohm Co., Ltd マイクロ流路及びマイクロ流体チップ
JP2006239538A (ja) * 2005-03-02 2006-09-14 Rohm Co Ltd マイクロ流路及びマイクロチップ
JP2007171172A (ja) * 2005-12-21 2007-07-05 Samsung Electronics Co Ltd 流体のｐＨを電気化学的に調節するための微細流動装置、及び該装置の内部の流体のｐＨを電気化学的に調節する方法
JPWO2007142061A1 (ja) * 2006-06-06 2009-10-22 コニカミノルタエムジー株式会社 マイクロチップ検査装置
JP2009139381A (ja) * 2007-12-04 2009-06-25 Headway Technologies Inc 被標識物質の捕捉・搬送装置並びに同定・計数方法および計数・選別方法
JP2011516034A (ja) * 2008-02-29 2011-05-26 ノースウエスタン ユニバーシティ 生物反応促進用バリア
US10107797B2 (en) 2008-10-03 2018-10-23 Micronics, Inc. Microfluidic apparatus and methods for performing blood typing and crossmatching
JP2012504952A (ja) * 2008-10-10 2012-03-01 ユニバーシティー オブ ハル Ｄｎａの抽出、増幅、及び分析のためのマイクロ流体装置及び方法
US9101933B2 (en) 2008-10-10 2015-08-11 University Of Hull Microfluidic apparatus and method for DNA extraction, amplification and analysis
JP2013527769A (ja) * 2010-05-06 2013-07-04 アイビス バイオサイエンシズ インコーポレイティッド 統合された試料調製システムおよび安定化酵素混合物
JP2016182127A (ja) * 2010-05-06 2016-10-20 アイビス バイオサイエンシズ インコーポレイティッド 統合された試料調製システムおよび安定化酵素混合物
US9737887B2 (en) 2010-05-06 2017-08-22 Ibis Biosciences, Inc. Integrated sample preparation systems and stabilized enzyme mixtures
JP2015504352A (ja) * 2011-10-31 2015-02-12 ゼネラル・エレクトリック・カンパニイ マイクロ流体チップ及びその関連方法
JP2016518922A (ja) * 2013-04-15 2016-06-30 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 生物学的流体採取デバイスならびに生物学的流体分離および検査システム
US10386377B2 (en) 2013-05-07 2019-08-20 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
US11016108B2 (en) 2013-05-07 2021-05-25 Perkinelmer Health Sciences, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
JP2017526352A (ja) * 2014-08-05 2017-09-14 ザ チャールズ スターク ドレイパー ラボラトリー インク 流体レベリング装置を組み込む流体循環システム
JP2021502546A (ja) * 2017-11-09 2021-01-28 インターナショナル・ビジネス・マシーンズ・コーポレーションＩｎｔｅｒｎａｔｉｏｎａｌ Ｂｕｓｉｎｅｓｓ Ｍａｃｈｉｎｅｓ Ｃｏｒｐｏｒａｔｉｏｎ 検体検出のためのｐＨ制御デバイス、センサデバイス及びｐＨを制御するための方法
JP2021531975A (ja) * 2018-07-26 2021-11-25 レックス ダイアグノスティックス リミテッド 可変温度反応器、可変温度反応器のためのヒータおよび制御回路
WO2022070669A1 (ja) * 2020-09-29 2022-04-07 Nok株式会社 粒子解析装置およびその製造方法
JP2024506655A (ja) * 2021-02-13 2024-02-14 アプティテュード メディカル システムズ、インコーポレイテッド サンプルを分析するためのシステム及び方法

Also Published As

Publication number Publication date
DE69637443D1 (de) 2008-04-03
US5856174A (en) 1999-01-05
ATE235559T1 (de) 2003-04-15
US6197595B1 (en) 2001-03-06
EP1304388A3 (en) 2003-05-28
US20050250199A1 (en) 2005-11-10
EP1304388A2 (en) 2003-04-23
US6326211B1 (en) 2001-12-04
DE69626988T2 (de) 2004-03-04
ATE386590T1 (de) 2008-03-15
DE69637443T2 (de) 2008-06-12
EP0843734A1 (en) 1998-05-27
EP0843734B1 (en) 2003-03-26
AU6404996A (en) 1997-02-05
US6043080A (en) 2000-03-28
EP1304388B1 (en) 2008-02-20
US6830936B2 (en) 2004-12-14
US20010036672A1 (en) 2001-11-01
EP0843734A4 (en) 1999-10-06
DE69626988D1 (de) 2003-04-30
US5922591A (en) 1999-07-13
WO1997002357A1 (en) 1997-01-23

Similar Documents

Publication Publication Date Title
JPH11509094A (ja) 統合された核酸診断装置
US6168948B1 (en) Miniaturized genetic analysis systems and methods
US20020022261A1 (en) Miniaturized genetic analysis systems and methods
JP4176124B2 (ja) 中規模ポリヌクレオチド増幅方法
JP5523327B2 (ja) 統合型マイクロ流体デバイスおよび方法
US20050019902A1 (en) Miniaturized integrated nucleic acid processing and analysis device and method
US11203787B2 (en) Methods and systems for detecting biological components
JP3558294B2 (ja) 微細加工装置を用いたポリヌクレオチド増幅分析
US6660517B1 (en) Mesoscale polynucleotide amplification devices
CN100503838C (zh) 用于分析核酸的微流系统
US20050100946A1 (en) Integrated nucleic acid diagnostic device and method for in-situ confocal microscopy
JP4522480B2 (ja) 一体型流体操作カートリッジ
CN1732044A (zh) 用于核酸分析的显微流体系统
CN1732045A (zh) 使用薄膜层引导流体的微流体系统
EP1003759A2 (en) Microstructures for the manipulation of fluid samples
AU698213C (en) Mesoscale polynucleotide amplification devices

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20060606

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20060906

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20061023

A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20070129

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20070410