JP2015504352A - マイクロ流体チップ及びその関連方法 - Google Patents
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Abstract
Description
11 マクロ室の入力端
12 マクロ室
13 マクロ室の出力端
14 混合装置
16 流体室
18 マイクロ流体反応装置
20、22 試薬
24 試薬混合物
26 押出し流体
28 流体供給源
30 反応内容物
32 マイクロ流体チップ
34、36、38、40、42 試薬供給源
44 マクロ室
46 混合装置
48 流体室
50 マイクロ流体反応装置
52、58、60、62、64 流路
66、68、70、72、74 チップ−外部供給源間接続部
76 流体供給源
78、84、94、100、102、110 流路
80、82、96 制御弁
86、106、112、114、116 流れ制御弁
92 生成物室
98、108 流れ制御装置
104 廃棄物室
118 マイクロ流体チップ
120 流体室
122、123、125 マイクロ流体反応装置
124、134 チャンネル
126 制御弁
127 スイッチング装置
128 流れチャンネル
130、136 流れ制御弁
132 廃棄チャンネル
138 センサ
140 チャンネルの一部分
142、144 光線
Claims (29)
- 複数の試薬を供給するための複数の試薬供給源であって、各試薬供給源が複数の試薬の内の対応する試薬を供給する複数の試薬供給源と、
前記複数の試薬供給源からの前記複数の試薬の内の1つ以上の試薬を受け取るためのマクロ室と、
前記マクロ室及び前記複数の試薬供給源に結合されたマイクロ流体反応装置であって、前記マクロ室及び前記複数の試薬供給源の内の少なくとも1つから前記複数の試薬の内の2つ以上の試薬を受け取って、該2つ以上の試薬を反応させて反応内容物を生成するように構成されたマイクロ流体反応装置と、
を有するマイクロ流体チップ。 - 更に、前記複数の試薬供給源、前記マクロ室及び前記マイクロ流体反応装置の内の少なくとも1つに結合された混合装置であって、前記複数の試薬の内の2つ以上の試薬を混合して該2つ以上の試薬の混合物を生成するように構成された混合装置を有している請求項1記載のマイクロ流体チップ。
- 前記マイクロ流体反応装置は前記混合装置を介して前記マクロ室及び前記複数の試薬供給源に結合されている、請求項2記載のマイクロ流体チップ。
- 前記混合装置は、前記複数の試薬供給源から2つ以上の試薬を受け取り、該2つ以上の試薬を混合して、該2つ以上の試薬の混合物を前記マクロ室及び前記マイクロ流体反応装置の内の少なくとも1つへ供給するように構成されている、請求項2記載のマイクロ流体チップ。
- 前記混合装置は、前記マクロ室から前記複数の試薬の内の2つ以上の試薬を受け取り、該2つ以上の試薬を混合して、該2つ以上の試薬の混合物を前記マイクロ流体反応装置へ供給するように構成されている、請求項2記載のマイクロ流体チップ。
- 前記マイクロ流体反応装置は、前記混合装置を介して前記マクロ室へ前記反応内容物を供給する、請求項2記載のマイクロ流体チップ。
- 前記混合装置は前記マクロ室に統合されていて、前記マクロ室内で前記複数の試薬の内の2つ以上の試薬を混合するように構成されている、請求項2記載のマイクロ流体チップ。
- 前記混合装置は前記マイクロ流体反応装置に統合されていて、前記マイクロ流体反応装置内で前記複数の試薬の内の2つ以上の試薬を混合するように構成されている、請求項2記載のマイクロ流体チップ。
- 前記混合装置は、前記マクロ室内で前記複数の試薬の内の2つ以上の試薬の混合を可能にするようにガス・バブルを前記マクロ室へ供給するためのガス・バブル供給源を有している、請求項2記載のマイクロ流体チップ。
- 前記マイクロ流体チップは更に、マーカー流体を貯蔵するための流体室を有し、前記マイクロ流体反応装置が前記流体室を介して前記マクロ室に結合されている、請求項1記載のマイクロ流体チップ。
- 前記マーカーは、異なる属性を持つ蛍光液体及びガスの内の少なくとも1つを有している、請求項10記載のマイクロ流体チップ。
- 更に、前記マクロ室から2つ以上の試薬の混合物又は前記反応内容物を押し出すように前記マクロ室へ押出し流体を供給して、前記2つ以上の試薬の混合物又は前記反応内容物が前記マーカー流体と前記押出し流体との間に配置されたスラグとして前記マイクロ流体反応装置へ輸送されるようにする流体供給源を有する請求項10記載のマイクロ流体チップ。
- 更に、前記チップの少なくとも1つの位置で前記押出し流体と前記2つ以上の試薬の混合物又は前記反応内容物との間の界面を検知するために、前記チップの少なくとも1つの位置に配置された少なくとも1つのセンサを有している請求項12記載のマイクロ流体チップ。
- 更に、前記少なくとも1つのセンサからの出力に基づいて前記複数の試薬供給源と前記マクロ室と前記マイクロ流体反応装置との間の前記試薬及び前記反応内容物の流れを制御するための閉ループ制御システムを有している、請求項13記載のマイクロ流体チップ。
- 更に、前記複数の試薬供給源と前記マクロ室と前記マイクロ流体反応装置との間の前記試薬及び前記反応内容物の流れを制御するための開ループ制御システムを有している請求項1記載のマイクロ流体チップ。
- 前記マイクロ流体反応装置は第1の温度に維持され、また前記マクロ室は前記第1の温度とは異なる第2の温度に維持される、請求項1記載のマイクロ流体チップ。
- 前記マイクロ流体反応装置及び前記マクロ室は予め規定された温度に維持される、請求項1記載のマイクロ流体チップ。
- 更に、前記複数の試薬供給源と前記マクロ室と前記マイクロ流体反応装置との間の前記試薬及び前記反応内容物の流れを制御するための複数のオン・チップ弁を有している、請求項1記載のマイクロ流体チップ。
- 前記マイクロ流体反応装置は複数の反応装置を有しており、この場合、前記マクロ室は、前記マクロ室と前記複数の反応装置との間の前記複数の試薬又は前記反応内容物の流れを制御するように構成されたスイッチング装置を介して、前記複数の反応装置に結合される、請求項1記載のマイクロ流体チップ。
- 前記マイクロ流体反応装置は前記マクロ室に統合されている、請求項1記載のマイクロ流体チップ。
- 複数の試薬供給源からの複数の試薬の内の2つ以上の試薬をマクロ室へ供給する段階と、
前記マクロ室及び前記複数の試薬供給源の内の少なくとも1つから前記複数の試薬の内の2つ以上の試薬をマイクロ流体反応装置へ供給する段階と、
前記マイクロ流体反応装置内で前記複数の試薬の内の前記2つ以上の試薬を反応させて反応内容物を生成する段階と、を有する方法であって、
前記マクロ室及び前記マイクロ流体反応装置がマイクロ流体チップ内に配置されている、方法。 - 前記複数の試薬供給源から2つ以上の試薬を混合装置へ供給し、該混合装置により前記2つ以上の試薬を混合して、前記マクロ室及び前記マイクロ流体反応装置の内の少なくとも1つへ2つ以上の試薬の混合物を供給する段階を有している請求項21載の方法。
- 前記マクロ室から前記複数の試薬の内の2つ以上の試薬を混合装置へ供給し、該混合装置により前記2つ以上の試薬を混合して、2つ以上の試薬の混合物を前記マイクロ流体反応装置へ供給する段階を有している請求項21載の方法。
- 前記マイクロ流体反応装置から混合装置を介して前記マクロ室へ前記反応内容物を供給する段階を有している請求項21載の方法。
- 前記マイクロ流体反応装置内で前記2つ以上の試薬を混合する段階を有している請求項21載の方法。
- 前記マクロ室で前記2つ以上の試薬を混合する段階を有している請求項21載の方法。
- 更に、前記マクロ室から2つ以上の試薬の混合物又は前記反応内容物を押し出すように流体供給源から前記マクロ室へ押出し流体を供給して、前記2つ以上の試薬の混合物又は前記反応内容物が、流体室に貯蔵されているマーカー流体と前記押出し流体との間に配置されたスラグとして前記マイクロ流体反応装置へ輸送されるようにする段階を有している請求項21載の方法。
- 更に、前記マクロ室の入力端から正の圧力又は負の圧力を用いて前記マクロ室から2つ以上の試薬の混合物又は前記反応内容物を押し出して、前記2つ以上の試薬の混合物又は前記反応内容物が、流体室に貯蔵されているマーカー流体と前記押出し流体との間に配置されたスラグとして前記マイクロ流体反応装置へ輸送されるようにする段階を有している請求項21載の方法。
- 更に、前記マクロ室の出力端から正の圧力又は負の圧力を用いて前記マクロ室から2つ以上の試薬の混合物又は前記反応内容物を押し出して、前記2つ以上の試薬の混合物又は前記反応内容物が、前記押出し流体と前記マーカー流体との間に配置されたスラグとして前記マイクロ流体反応装置へ輸送されるようにする段階を有している請求項28載の方法。
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US9399216B2 (en) * | 2013-12-30 | 2016-07-26 | General Electric Company | Fluid transport in microfluidic applications with sensors for detecting fluid presence and pressure |
US10473668B2 (en) * | 2014-06-06 | 2019-11-12 | The Regents Of The University Of California | Self-shielded, benchtop radio chemistry system with a plurality shielded carriers containing a disposable chip cassette |
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