JP6167040B2 - Ｆｃドメイン中に突然変異を有する、安定したヘテロ二量体抗体の設計 - Google Patents

Ｆｃドメイン中に突然変異を有する、安定したヘテロ二量体抗体の設計 Download PDF

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JP6167040B2
JP6167040B2 JP2013536966A JP2013536966A JP6167040B2 JP 6167040 B2 JP6167040 B2 JP 6167040B2 JP 2013536966 A JP2013536966 A JP 2013536966A JP 2013536966 A JP2013536966 A JP 2013536966A JP 6167040 B2 JP6167040 B2 JP 6167040B2
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amino acid
domain polypeptide
polypeptide comprises
comprises amino
acid modifications
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JP2014504265A5 (enExample
JP2014504265A (ja
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エスコバル カブレラ、エリック
エスコバル カブレラ、エリック
クロイデンシュタイン、トーマス スプレター フォン
クロイデンシュタイン、トーマス スプレター フォン
ビーマラオ ディキシット、スルジット
ビーマラオ ディキシット、スルジット
イレーネ ラリオ、ポーラ
イレーネ ラリオ、ポーラ
カイ ユエン プーン、デイヴィッド
カイ ユエン プーン、デイヴィッド
エドモンド パオロ ダンジェロ、イゴール
エドモンド パオロ ダンジェロ、イゴール
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ザイムワークス，インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2013536966A 2010-11-05 2011-11-04 Ｆｃドメイン中に突然変異を有する、安定したヘテロ二量体抗体の設計 Active JP6167040B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US41074610P 2010-11-05 2010-11-05
US61/410,746 2010-11-05
US201061425375P 2010-12-21 2010-12-21
US61/425,375 2010-12-21
US201161439341P 2011-02-03 2011-02-03
US61/439,341 2011-02-03
US201161475614P 2011-04-14 2011-04-14
US61/475,614 2011-04-14
US201161491846P 2011-05-31 2011-05-31
US61/491,846 2011-05-31
US201161497861P 2011-06-16 2011-06-16
US61/497,861 2011-06-16
PCT/CA2011/001238 WO2012058768A1 (en) 2010-11-05 2011-11-04 Stable heterodimeric antibody design with mutations in the fc domain

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Publication Number Publication Date
JP2014504265A JP2014504265A (ja) 2014-02-20
JP2014504265A5 JP2014504265A5 (enExample) 2014-12-25
JP6167040B2 true JP6167040B2 (ja) 2017-07-19

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US (4) US9562109B2 (enExample)
EP (1) EP2635607B1 (enExample)
JP (1) JP6167040B2 (enExample)
KR (2) KR20130135866A (enExample)
CN (2) CN103429620B (enExample)
AU (1) AU2011325833C1 (enExample)
CA (1) CA2815266C (enExample)
CY (1) CY1122409T1 (enExample)
DK (1) DK2635607T3 (enExample)
ES (1) ES2758994T3 (enExample)
HR (1) HRP20192045T1 (enExample)
HU (1) HUE047228T2 (enExample)
MX (1) MX352929B (enExample)
PL (1) PL2635607T3 (enExample)
PT (1) PT2635607T (enExample)
RS (1) RS59589B1 (enExample)
RU (1) RU2604490C2 (enExample)
WO (1) WO2012058768A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12415857B2 (en) 2021-06-25 2025-09-16 Chugai Seiyaku Kabushiki Kaisha Anti-CTLA-4 antibody and use thereof

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US12448451B2 (en) 2021-06-25 2025-10-21 Chugai Seiyaku Kabushiki Kaisha Anti-CTLA-4 antibody and use thereof

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