CA2815266C - Stable heterodimeric antibody design with mutations in the fc domain - Google Patents

Stable heterodimeric antibody design with mutations in the fc domain Download PDF

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Publication number
CA2815266C
CA2815266C CA2815266A CA2815266A CA2815266C CA 2815266 C CA2815266 C CA 2815266C CA 2815266 A CA2815266 A CA 2815266A CA 2815266 A CA2815266 A CA 2815266A CA 2815266 C CA2815266 C CA 2815266C
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amino acid
domain polypeptide
domain
region
heterodimer
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French (fr)
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CA2815266A1 (en
Inventor
Eric Escobar Cabrera
Thomas SPRETER VON KREUDENSTEIN
Surjit Bhimarao Dixit
Paula Irene Lario
David Kai Yuen Poon
Igor Edmondo Paolo D'angelo
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Zymeworks BC Inc
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Zymeworks BC Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2815266A 2010-11-05 2011-11-04 Stable heterodimeric antibody design with mutations in the fc domain Active CA2815266C (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US41074610P 2010-11-05 2010-11-05
US61/410,746 2010-11-05
US201061425375P 2010-12-21 2010-12-21
US61/425,375 2010-12-21
US201161439341P 2011-02-03 2011-02-03
US61/439,341 2011-02-03
US201161475614P 2011-04-14 2011-04-14
US61/475,614 2011-04-14
US201161491846P 2011-05-31 2011-05-31
US61/491,846 2011-05-31
US201161497861P 2011-06-16 2011-06-16
US61/497,861 2011-06-16
PCT/CA2011/001238 WO2012058768A1 (en) 2010-11-05 2011-11-04 Stable heterodimeric antibody design with mutations in the fc domain

Publications (2)

Publication Number Publication Date
CA2815266A1 CA2815266A1 (en) 2012-05-10
CA2815266C true CA2815266C (en) 2023-09-05

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ID=46023901

Family Applications (1)

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CA2815266A Active CA2815266C (en) 2010-11-05 2011-11-04 Stable heterodimeric antibody design with mutations in the fc domain

Country Status (19)

Country Link
US (4) US9562109B2 (enExample)
EP (1) EP2635607B1 (enExample)
JP (1) JP6167040B2 (enExample)
KR (2) KR20130135866A (enExample)
CN (2) CN103429620B (enExample)
AU (1) AU2011325833C1 (enExample)
BR (1) BR112013011811A2 (enExample)
CA (1) CA2815266C (enExample)
CY (1) CY1122409T1 (enExample)
DK (1) DK2635607T3 (enExample)
ES (1) ES2758994T3 (enExample)
HR (1) HRP20192045T1 (enExample)
HU (1) HUE047228T2 (enExample)
MX (1) MX352929B (enExample)
PL (1) PL2635607T3 (enExample)
PT (1) PT2635607T (enExample)
RS (1) RS59589B1 (enExample)
RU (1) RU2604490C2 (enExample)
WO (1) WO2012058768A1 (enExample)

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