CY1122409T1 - Σχεδιασμος σταθερου ετεροδιμερικου αντισωματος με μεταλαξεις στην επικρατεια fc - Google Patents

Σχεδιασμος σταθερου ετεροδιμερικου αντισωματος με μεταλαξεις στην επικρατεια fc

Info

Publication number
CY1122409T1
CY1122409T1 CY20191101259T CY191101259T CY1122409T1 CY 1122409 T1 CY1122409 T1 CY 1122409T1 CY 20191101259 T CY20191101259 T CY 20191101259T CY 191101259 T CY191101259 T CY 191101259T CY 1122409 T1 CY1122409 T1 CY 1122409T1
Authority
CY
Cyprus
Prior art keywords
mutations
region
design
heterodimer antibody
stable heterodimer
Prior art date
Application number
CY20191101259T
Other languages
Greek (el)
English (en)
Inventor
Eric Escobar Cabrera
Thomas Spreter Von Kreudenstein
Surjit Bhimarao Dixit
Paula Irene Lario
David Kai Yuen Poon
Igor Edmondo Paolo D'angelo
Original Assignee
Zymeworks Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymeworks Inc. filed Critical Zymeworks Inc.
Publication of CY1122409T1 publication Critical patent/CY1122409T1/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/524CH2 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/526CH3 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CY20191101259T 2010-11-05 2019-12-02 Σχεδιασμος σταθερου ετεροδιμερικου αντισωματος με μεταλαξεις στην επικρατεια fc CY1122409T1 (el)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US41074610P 2010-11-05 2010-11-05
US201061425375P 2010-12-21 2010-12-21
US201161439341P 2011-02-03 2011-02-03
US201161475614P 2011-04-14 2011-04-14
US201161491846P 2011-05-31 2011-05-31
US201161497861P 2011-06-16 2011-06-16
PCT/CA2011/001238 WO2012058768A1 (en) 2010-11-05 2011-11-04 Stable heterodimeric antibody design with mutations in the fc domain

Publications (1)

Publication Number Publication Date
CY1122409T1 true CY1122409T1 (el) 2021-01-27

Family

ID=46023901

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191101259T CY1122409T1 (el) 2010-11-05 2019-12-02 Σχεδιασμος σταθερου ετεροδιμερικου αντισωματος με μεταλαξεις στην επικρατεια fc

Country Status (19)

Country Link
US (4) US9562109B2 (enExample)
EP (1) EP2635607B1 (enExample)
JP (1) JP6167040B2 (enExample)
KR (2) KR20130135866A (enExample)
CN (2) CN103429620B (enExample)
AU (1) AU2011325833C1 (enExample)
BR (1) BR112013011811A2 (enExample)
CA (1) CA2815266C (enExample)
CY (1) CY1122409T1 (enExample)
DK (1) DK2635607T3 (enExample)
ES (1) ES2758994T3 (enExample)
HR (1) HRP20192045T1 (enExample)
HU (1) HUE047228T2 (enExample)
MX (1) MX352929B (enExample)
PL (1) PL2635607T3 (enExample)
PT (1) PT2635607T (enExample)
RS (1) RS59589B1 (enExample)
RU (1) RU2604490C2 (enExample)
WO (1) WO2012058768A1 (enExample)

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