BR112014010257A2 - molécula de ligação ao antígeno tendo conjugação regulada entre cadeias pesadas e cadeias leves - Google Patents

molécula de ligação ao antígeno tendo conjugação regulada entre cadeias pesadas e cadeias leves

Info

Publication number
BR112014010257A2
BR112014010257A2 BR112014010257A BR112014010257A BR112014010257A2 BR 112014010257 A2 BR112014010257 A2 BR 112014010257A2 BR 112014010257 A BR112014010257 A BR 112014010257A BR 112014010257 A BR112014010257 A BR 112014010257A BR 112014010257 A2 BR112014010257 A2 BR 112014010257A2
Authority
BR
Brazil
Prior art keywords
conjugation
regulated
heavy
antigen binding
binding molecule
Prior art date
Application number
BR112014010257A
Other languages
English (en)
Inventor
Kawazoe Meiri
Hironiwa Naoka
Kuramochi Taichi
Igawa Tomoyuki
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48192053&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014010257(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of BR112014010257A2 publication Critical patent/BR112014010257A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

resumo patente de invenção: "molécula de ligação ao antígeno tendo conjugação regulada entre cadeias pesadas e cadeias leves". constatou-se que a associação entre ch1 e cl pode ser suprimida substituindo-se os aminoácidos presentes na interface entre ch1 e cl por aminoácidos eletricamente carregados, e que a formação de moléculas heterogêneas é capacitada de modo mais eficiente do que introduzindo-se mutações knobs into holes no domínio ch3.
BR112014010257A 2011-10-31 2012-10-31 molécula de ligação ao antígeno tendo conjugação regulada entre cadeias pesadas e cadeias leves BR112014010257A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011238873 2011-10-31
PCT/JP2012/078103 WO2013065708A1 (ja) 2011-10-31 2012-10-31 重鎖と軽鎖の会合が制御された抗原結合分子

Publications (1)

Publication Number Publication Date
BR112014010257A2 true BR112014010257A2 (pt) 2017-04-18

Family

ID=48192053

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014010257A BR112014010257A2 (pt) 2011-10-31 2012-10-31 molécula de ligação ao antígeno tendo conjugação regulada entre cadeias pesadas e cadeias leves

Country Status (12)

Country Link
US (2) US11851476B2 (pt)
EP (1) EP2787078B1 (pt)
JP (2) JP6371059B2 (pt)
KR (2) KR102168733B1 (pt)
CN (3) CN109134658B (pt)
BR (1) BR112014010257A2 (pt)
CA (1) CA2853230C (pt)
ES (1) ES2732712T3 (pt)
HK (2) HK1259058A1 (pt)
MX (1) MX359775B (pt)
RU (1) RU2681885C2 (pt)
WO (1) WO2013065708A1 (pt)

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