BR112015023142A2 - moduladores de p2x7 - Google Patents

moduladores de p2x7

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Publication number
BR112015023142A2
BR112015023142A2 BR112015023142A BR112015023142A BR112015023142A2 BR 112015023142 A2 BR112015023142 A2 BR 112015023142A2 BR 112015023142 A BR112015023142 A BR 112015023142A BR 112015023142 A BR112015023142 A BR 112015023142A BR 112015023142 A2 BR112015023142 A2 BR 112015023142A2
Authority
BR
Brazil
Prior art keywords
formulas
compounds
iia
iib
relates
Prior art date
Application number
BR112015023142A
Other languages
English (en)
Other versions
BR112015023142B1 (pt
BR112015023142A8 (pt
Inventor
Soyode-Johnson Akinola
M Savall Brad
D Allison Brett
M Stenne Brice
C Chrovian Christa
F Gelin Christine
A Dvorak Curt
M Swanson Devin
R Coate Heather
C Rech Jason
L Wall Jessica
T Liang Jimmy
Ignacio Andres Gil Jose
Jesus Alcazar Vaca Manuel
De Angelis Meri
A Letavic Michael
S Mani Neelakandha
Deng Xiaohu
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR112015023142A2 publication Critical patent/BR112015023142A2/pt
Publication of BR112015023142A8 publication Critical patent/BR112015023142A8/pt
Publication of BR112015023142B1 publication Critical patent/BR112015023142B1/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
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    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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  • Health & Medical Sciences (AREA)
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Abstract

abstract the present invention is directed to compounds of formulas (i, ia, iia and iib): the invention also relates to pharmaceutical compositions comprising compounds of formulas (i, ia, iia and iib). methods of making and using the compounds of formulas (i, ia, iia and iib) are also within the scope of the invention. ----------------------------------------------------------------------------------------------------tradução do resumo resumo patente de invenção: "moduladores de p2x7". a presente invenção refere-se aos compostos de fórmulas (i, ia, iia e iib): a invenção refere-se também às composições farmacêuticas que compreendem os compostos de fórmulas (i, ia, iia e iib). os métodos para fazer e usar os compostos das fórmulas (i, ia, iia e iib) também estão dentro do escopo da invenção.
BR112015023142-0A 2013-03-14 2014-03-14 Moduladores do p2x7, seu uso, processo de preparação e composição farmacêutica que os compreende BR112015023142B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361786260P 2013-03-14 2013-03-14
US61/786,260 2013-03-14
PCT/US2014/027522 WO2014152604A1 (en) 2013-03-14 2014-03-14 P2x7 modulators

Publications (3)

Publication Number Publication Date
BR112015023142A2 true BR112015023142A2 (pt) 2017-07-18
BR112015023142A8 BR112015023142A8 (pt) 2019-12-03
BR112015023142B1 BR112015023142B1 (pt) 2023-05-02

Family

ID=50543353

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015023142-0A BR112015023142B1 (pt) 2013-03-14 2014-03-14 Moduladores do p2x7, seu uso, processo de preparação e composição farmacêutica que os compreende

Country Status (33)

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US (8) US10112937B2 (pt)
EP (3) EP2970267B3 (pt)
JP (1) JP6293861B2 (pt)
KR (4) KR102500076B1 (pt)
CN (2) CN105209464B (pt)
AR (2) AR095530A1 (pt)
AU (5) AU2014239291B2 (pt)
BR (1) BR112015023142B1 (pt)
CA (1) CA2906085C (pt)
CL (3) CL2015002655A1 (pt)
CY (1) CY1119110T1 (pt)
DK (2) DK3239151T3 (pt)
EA (1) EA028816B1 (pt)
ES (2) ES2704024T3 (pt)
HK (1) HK1218541A1 (pt)
HR (1) HRP20171168T4 (pt)
HU (1) HUE032877T2 (pt)
IL (1) IL240880B (pt)
JO (1) JO3773B1 (pt)
LT (1) LT2970267T (pt)
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