CY1119110T1 - Ρυθμιστες ρ2χ7 - Google Patents

Ρυθμιστες ρ2χ7

Info

Publication number
CY1119110T1
CY1119110T1 CY20171100794T CY171100794T CY1119110T1 CY 1119110 T1 CY1119110 T1 CY 1119110T1 CY 20171100794 T CY20171100794 T CY 20171100794T CY 171100794 T CY171100794 T CY 171100794T CY 1119110 T1 CY1119110 T1 CY 1119110T1
Authority
CY
Cyprus
Prior art keywords
llb
lla
formulas
compounds
regulators
Prior art date
Application number
CY20171100794T
Other languages
English (en)
Inventor
Manuel Jesus Alcazar-Vaca
Brett D Allison
Gil Jose Ignacio Andres
Christa C Chrovian
Heather R Coate
Angelis Meri De
Xiaohu Deng
Curt A Dvorak
Christine F Gelin
Michael A Letavic
Jimmy T Liang
Neelakandha S Mani
Jason C Rech
Brad M Savall
Akinola Soyode-Johnson
Brice M Stenne
Devin M Swanson
Jessica L Wall
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CY1119110T1 publication Critical patent/CY1119110T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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    • A61K9/0012—Galenical forms characterised by the site of application
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    • C—CHEMISTRY; METALLURGY
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

Η παρούσα εφεύρεση κατευθύνεται σε ενώσεις των τύπων (I, la, lla και llb): Η εφεύρεση επίσης αφορά σε φαρμακευτικές συνθέσεις που περιλαμβάνουν ενώσεις των τύπων (I, la, lla και llb). Μέθοδοι κατασκευής και χρήσης των ενώσεων των τύπων (I, la, lla και llb) επίσης ευρίσκονται εντός του σκοπού της εφεύρεσης.
CY20171100794T 2013-03-14 2017-07-25 Ρυθμιστες ρ2χ7 CY1119110T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361786260P 2013-03-14 2013-03-14
PCT/US2014/027522 WO2014152604A1 (en) 2013-03-14 2014-03-14 P2x7 modulators

Publications (1)

Publication Number Publication Date
CY1119110T1 true CY1119110T1 (el) 2018-02-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100794T CY1119110T1 (el) 2013-03-14 2017-07-25 Ρυθμιστες ρ2χ7

Country Status (33)

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US (8) US9066946B2 (el)
EP (3) EP3495365A1 (el)
JP (1) JP6293861B2 (el)
KR (4) KR102319857B1 (el)
CN (2) CN110003200B (el)
AR (2) AR095530A1 (el)
AU (5) AU2014239291B2 (el)
BR (1) BR112015023142B1 (el)
CA (1) CA2906085C (el)
CL (3) CL2015002655A1 (el)
CY (1) CY1119110T1 (el)
DK (2) DK3239151T3 (el)
EA (1) EA028816B1 (el)
ES (2) ES2704024T3 (el)
HK (1) HK1218541A1 (el)
HR (1) HRP20171168T4 (el)
HU (1) HUE032877T2 (el)
IL (1) IL240880B (el)
JO (1) JO3773B1 (el)
LT (1) LT2970267T (el)
ME (1) ME02802B (el)
MX (2) MX364796B (el)
PH (1) PH12015501930A1 (el)
PL (1) PL2970267T6 (el)
PT (2) PT2970267T (el)
RS (1) RS56315B2 (el)
SG (2) SG11201507259UA (el)
SI (1) SI2970267T1 (el)
TW (2) TWI644671B (el)
UA (1) UA116467C2 (el)
UY (3) UY39887A (el)
WO (1) WO2014152604A1 (el)
ZA (1) ZA201507627B (el)

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TWI627174B (zh) 2013-03-14 2018-06-21 比利時商健生藥品公司 Ｐ２ｘ７調控劑
NZ710034A (en) 2013-03-14 2020-06-26 Boehringer Ingelheim Int Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c
EP2970271B1 (en) 2013-03-14 2017-11-08 Janssen Pharmaceutica NV P2x7 modulators
JO3773B1 (ar) 2013-03-14 2021-01-31 Janssen Pharmaceutica Nv معدلات p2x7
WO2014152537A1 (en) 2013-03-14 2014-09-25 Janssen Pharmaceutica Nv P2x7 modulators
GB201321748D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
WO2015172196A1 (en) * 2014-05-13 2015-11-19 Monash University Heterocyclic compounds and use of same
KR102510588B1 (ko) 2014-09-12 2023-03-17 베링거 인겔하임 인터내셔날 게엠베하 카텝신 c의 스피로사이클릭 억제제
ES2714048T3 (es) 2014-09-12 2019-05-24 Janssen Pharmaceutica Nv Moduladores de P2X7
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