ME02802B - P2x7 modulatori - Google Patents

P2x7 modulatori

Info

Publication number
ME02802B
ME02802B MEP-2017-160A MEP2017160A ME02802B ME 02802 B ME02802 B ME 02802B ME P2017160 A MEP2017160 A ME P2017160A ME 02802 B ME02802 B ME 02802B
Authority
ME
Montenegro
Prior art keywords
phenyl
methyl
trifluoromethyl
pyridin
dihydro
Prior art date
Application number
MEP-2017-160A
Other languages
German (de)
English (en)
French (fr)
Inventor
Vaca Manuel Jesus Alcazar
Brett D Allison
Gil Jose Ignacio Andres
Christa C Chrovian
Heather R Coate
Angelis Meri De
Xiaohu Deng
Curt A Dvorak
Christine F Gelin
Michael A Letavic
Jimmy T Liang
Neelakandha S Mani
Jason C Rech
Brad M Savall
Akinola Soyode-Johnson
Brice M Stenne
Devin M Swanson
Jessica L Wall
Original Assignee
Lutovac Vuk
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lutovac Vuk, Janssen Pharmaceutica Nv filed Critical Lutovac Vuk
Publication of ME02802B publication Critical patent/ME02802B/me

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Claims (16)

1. Jedinjenje formule (I): gde je R1 (a) fenil, opciono supstituisan sa nula do četiri grupe nezavisno izabrane iz grupe koju čine halo, C1-C4alkil, alkoksi, perhaloalkil i perhaloalkoksi; ili (b) heteroaril, nezavisno izabran iz grupe koju čine: igde Rk je nezavisno izabran iz grupe koju čine H, halo, C1-C3alkil, hidroksil, perhaloalkil i alkoksi; Rj je nezavisno izabran između H ili C1-C3alkil gde C1-C3alkil je opciono supstituisan sa od jedan do tri halo susptituenta, jednim OH supstituentom ili alkoksi supstituentom; i n je ceo broj od 0-3; X je N ili CR2; R2 je H, perhaloalkil ili C1-C3 niži alkil; R3 je H, perhaloalkil, C1-C4 alkil, alkalkoksi, CH2Ri, -C(O)Re ili fenil, gde pomenuti fenil je opciono supstituisan sa nula do dve grupe nezavisno izabrane iz grupe koju čine halo, C1-C3alkil, alkoksi, perhaloalkil i perhaloalkoksi; Ri je OH, NC3H6, N(C1-C3alkil)2 ili halo; Re je OH, OC1-C3 alkil, N(C1-C3alkil)2, ili NC3H6; R4 i R5 su nezavisno H ili C1-C3 alkil; R8 je fenil ili piridil, opciono supstituisan sa nula do četiri Rm supstituenta gde Rm je nezavisno izabran iz grupe koju čine halo, C1-C3alkil, hidroksi, alkoksi, perhaloalkil i perhaloalkoksi; ili R8 je nezavisno izabran iz grupe koju čine: ii farmaceutski prihvatljive soli jedinjenja formule (I).
2. Jedinjenje prema zahtevu 1 gde, je R1 heteroaril, nezavisno izabran iz grupe koju čine: i ili gde, R1 je heteroaril, nezavisno izabran iz grupe koju čine: i ili, gde, R1 je heteroaril, nezavisno izabran iz grupe koju čine: i ili gde, R1 je ili gde, R1 je
3. Jedinjenje prema zahtevu 1 gde, R8 je fenil, ili gde, R8 je fenil, Rm je Cl u orto položaju, i Rm je CF3 u meta položaju, ili gde, R8 je piridil, opciono supstituisan sa nula do četiri Rm supstituenta gde Rm je nezavisno izabran iz grupe koju čine halo, C1-C3alkil, hidroksi, alkoksi, perhaloalkil i perhaloalkoksi, ili gde, R8 je 2-piridil, 3-piridil ili 4-piridil opciono supstituisan sa jedan do tri Rm supstituenta gde Rm je nezavisno izabran iz grupe koju čine halo, C1-C3alkil, perhaloalkil i perhaloalkoksi, ili gde, R8 je 4-piridil opciono supstituisan sa jedan do tri Rm supstituenta gde Rm je nezavisno izabran iz grupe koju čine: halo, perhaloalkil i perhaloalkoksi.
4. Jedinjenje prema zahtevu 1 gde, X je N, ili gde, X je CR2 i R2 je H.
5. Jedinjenje prema zahtevu 1 gde, R3 je CH3.
6. Jedinjenje prema zahtevu 1 gde, R4 i R5 su CH3 ili, gde, R4 je H i R5 je CH3 ili, gde, R4 je CH3 i R5 je H.
7. Jedinjenje prema zahtevu 1 gde, X je N, R3 je CH3, R4 i R5 su H, R8 je fenil, Rm je Cl u orto položaju, Rm je CF3 u meta položaju i R1 je: ili gde, X je N, R3 je CH3, R4 i R5 su H, R8 je fenil, Rm je Cl u orto položaju, Rm je CF3 u meta položaju i R1 je: ili gde, X je N, R3 je CH3, R4 i R5 su H, R8 je fenil, Rm je Cl u orto položaju, Rm je CF3 u meta položaju i R1 je: ili gde, X je N, R3 je CH3, R4 i R5 su H, R8 je fenil, Rm je Cl u orto položaju, Rm je CF3 u meta položaju i R1 je: ili gde, X je CR2, R3 je CH3, R4 i R5 su H, R8 je fenil, Rm je Cl u orto položaju, Rm je CF3 u meta položaju i R1 je: ili gde, X je N, R3 i R5 su H, R4 je CH3, R8 je fenil, Rm je F u orto položaju, Rm je CF3 u meta položaju i R1 je: ili gde, X je N, R3 i R5 su H, R4 je CH3, R8 je 4-piridil, Rm je F u orto položaju, Rm je CF3 u meta položaju i R1 je:
8. Jedinjenje formule IIa i IIb: gde: R3, R4 i R6 su nezavisno H ili C1-C3 alkil; R8 je fenil ili piridil, opciono supstituisan sa nula do tri Rm supstituenta gde Rm je nezavisno izabran iz grupe koju čine: halo, C1-C3alkil i perhaloalkil; R7 je (a) fenil, opciono supstituisan sa nula do dve grope nezavisno izabrane iz grupe koju čine halo i C1-C3alkil; ili (b) heteroaril, nezavisno izabran iz grupe koju čine: i gde Rk je halo ili C1-C3alkil; Rj je H ili C1-C3alkil; gde C1-C3alkil je opciono supstituisan sa jednim halo supstituentom ili jednim alkoksi supstituentom; i n je ceo broj od 0-3; i farmaceutski prihvatljive soli jedinjenja formule (IIa i IIb).
9. Jedinjenje kao u zahtevu 8 gde, R8 je fenil opciono supstituisan sa dva do tri Rm supstituenta nezavisno izabrana iz grupe koju čine halo, C1-C3alkil i perhaloalkil, ili gde, R8 je fenil opciono supstituisan sa dva do tri Rm supstituenta nezavisno izabrana iz grupe koju čine halo i perhaloalkil, ili gde, R8 je fenil, supstituisan sa dve Rm grupe, gde Rm je halo u orto položaju i Rm je perhaloalkil u meta položaju, ili gde, R8 je fenil, supstituisan sa dve Rm grupe, gde Rm je Cl u orto položaju i Rm je CF3 u meta položaju.
10. Jedinjenje prema zahtevu 8 gde, R3 je H i R4 je CH3, ili gde, R3 je CH3 i R4 je H.
11. Jedinjenje kao u zahtevu 8 gde, R7 je fenil, opciono supstituisan sa nula do dve grupe nezavisno izabrane iz grupe koju čine halo i C1-C3alkil ili, gde, R7 je heteroaril, nezavisno izabran iz grupe koju čine: i
12. Jedinjenje nezavisno izabrano iz grupe koju čine: (2-Hloro-3-(trifluorometil)fenil)(1-(piridin-2-il)-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-fenil-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (2,3-Dihlorofenil)(1-fenil-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (2,3-Dihlorofenil)(1-(piridin-2-il)-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (1-(1H-Pirazol-5-il)-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)(2-hloro-3-(trifluorometil)fenil)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(pirazin-2-il)-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(3,5-difluorofenil)-6,7-dihidro-1H-imidazo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(3-(piridin-2-il)-6,7-dihidro-3H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (2,3-Dihlorofenil)(3-(piridin-2-il)-6,7-dihidro-3H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(3-(pirazin-2-il)-6,7-dihidro-3H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(5-fluoropiridin-2-il)-4-metil-6,7-dihidro-1H-imidazo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(4-metil-1-fenil-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(4-metil-1-fenil-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (2-Fluoro-3-(trifluorometil)fenil)(4-metil-1-(pirazin-2-il)-6,7-dihidro-1H-imidazo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(4-etil-1-(pirazin-2-il)-6,7-dihidro-1H-imidazo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(4-izopropil-1-(pirazin-2-il)-6,7-dihidro-1H-imidazo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(4-metil-1-(piridin-2-il)-6,7-dihidro-1H-imidazo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(4-fluorofenil)-4-metil-6,7-dihidro-1H-imidazo[4,5-c]piridin5(4H)-il)metanon; (2-Fluoro-3-(trifluorometil)fenil)(4-metil-1-(piridin-2-il)-6,7-dihidro-1H-imidazo[4,5-c]piridin5(4H)-il)metanon; (2-Fluoro-3-(trifluorometil)fenil)(1-(4-fluorofenil)-4-metil-6,7-dihidro-1H-imidazo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(3-fluoropiridin-2-il)-4-metil-6,7-dihidro-1H-imidazo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-imidazo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(4-metil-1-(pirimidin-2-il)-6,7-dihidro-1H-imidazo[4,5-c]piridin5(4H)-il)metanon; Etil 5-(2-hloro-3-(trifluorometil)benzoil-1-(piridin-2-il)-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin-4karboksilat; Etil 5-(2,3-dihlorobenzoil-1-(piridin-2-il)-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin-4-karboksilat; Etil 5-(2-hloro-3-(trifluorometil)benzoil-1-fenil-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin-4-karboksilat; Etil 5-(2,3-dihlorobenzoil-1-fenil-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin-4-karboksilat; Etil 5-{[2-hloro-3-(trifluorometil)fenil]karbonil}-1-pirazin-2-il-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin-4-karboksilat; Etil 5-[(2,3-dihlorofenil)karbonil]-1-pirazin-2-il-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin-4-karboksilat; (5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-fenil-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin-4il)metanol; 1-(5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-piridin-2-il-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin4-il)-N,N-dimetilmetanamin; (2-Hloro-3-(trifluorometil)fenil)(4-(fluorometil)-1-(piridin-2-il)-6,7-dihidro-1H-imidazo[4,5-c]piridin5(4H)-il)metanon; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-piridin-2-il-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin-4karboksilna kiselina; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-N,N-dimetil-1-piridin-2-il-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin-4-karboksamid; 4-(Azetidin-1-ilkarbonil)-5-{[2-hloro-3-(trifluorometil)fenil]karbonil}-1-piridin-2-il-4,5,6,7-tetrahidro-1Himidazo[4,5-c]piridin; (5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-fenil-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin-4il)metil2-hloro-3-(trifluorometil)beonzat; (2-Hloro-3-(trifluorometil)fenil)(2-metil-1-fenil-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-fenil-2-(trifluorometil)-6,7-dihidro-1H-imidazo[4,5-c]piridin5(4H)-il)metanon; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4-(trifluorometil)-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin; (R*)-(2-hloro-3-(trifluorometil)fenil)(1-(5-fluoropiridin-2-il)-4-metil-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (4S*)-5-{[2-Fluoro-3-(trifluorometil)fenil]karbonil}-4-metil-1-piridin-2-il-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin; (4R*)-5-{[2-Fluoro-3-(trifluorometil)fenil]karbonil}-4-metil-1-piridin-2-il-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin; (4S*)-5-{[2-Fluoro-3-(trifluorometil)fenil]karbonil}-4-metil-1-piridin-2-il-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin; (4R*)-5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4-metil-1-piridin-2-il-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin; (4S*)-5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4-metil-1-piridin-2-il-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin; (4R*)-5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-(4-fluorofenil)-4-metil-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin; (4S*)-5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-(4-fluorofenil)-4-metil-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4,5,6,7-tetrahidro-3H-imidazo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-fenil-4,5-dihidro-1H-imidazo[4,5-c]piridin; 5-[(2,2-Difluoro-1,3-benzodioksol-4-il)karbonil]-1-fenil-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin; 5-(2,3-Dihidro-1-benzofuran-7-ilkarbonil)-1-fenil-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin; 5-[(2,2-Dimetil-2,3-dihidro-1-benzofuran-7-il)karbonil]-1-fenil-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4,4-dimetil-1-fenil-4,5,6,7-tetrahidro-1H-imidazo[4,5c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-pirazin-2-il-4,5-dihidro-1H-imidazo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4-etil-1-pirazin-2-il-4,5-dihidro-1H-imidazo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4-metil-1-pirazin-2-il-4,5-dihidro-1H-imidazo[4,5-c]piridin; 5-{[2-Fluoro-3-(trifluorometil)fenil]karbonil}-1-fenil-2-(trifluorometil)-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin; 5-[(2,3-Dihlorofenil)karbonil]-1-fenil-2-(trifluorometil)-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin; 5-{[2-Fluoro-3-(trifluorometil)fenil]karbonil}-1-(1H-pirazol-5-il)-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin; 5-[(2,3-Dihlorofenil)karbonil]-1-(1H-pirazol-5-il)-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-fenil-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-[(2,3-Dihlorofenil)karbonil]-1-fenil-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-piridin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-(5-fluoropirimidin-2-il)-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-pirimidin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5c]piridin; {[2-Fluoro-3-(trifluorometil)fenil]karbonil}-1-pirimidin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-[(2,3-Dihlorofenil)karbonil]-1-pirimidin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-(1H-pirazol-5-il)-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5c]piridin; 5-{[2-Fluoro-3-(trifluorometil)fenil]karbonil}-1-pirazin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-[(2,3-Dihlorofenil)karbonil]-1-pirazin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-(5-fluoropiridin-2-il)-4-metil-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4-metil-1-pirazin-2-il-4,5-dihidro-1H-[1,2,3]triazolo[4,5c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4-metil-1-pirazin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; (4R*)-5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4-metil-1-pirazin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; (4S*)-5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4-metil-1-pirazin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4-fenil-1-pirazin-2-il-4,5-dihidro-1H-[1,2,3]triazolo[4,5c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4-fenil-1-pirazin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4-fenil-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4-metil-1-pirimidin-2-il-4,5-dihidro-1H-[1,2,3]triazolo[4,5c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4-metil-1-pirimidin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-(4-fluorofenil)-4-metil-4,5-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-(3-fluoropiridin-2-il)-4-metil-4,5-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-(4-fluorofenil)-4-metil-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-(3-fluoropiridin-2-il)-4-metil-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4-metil-1-(1H-pirazol-3-il)-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4-metil-1-(1H-pirazol-3-il)-4,5-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin; (4S*)-5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4-metil-1-pirimidin-2-il-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; (4R*)-5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-4-metil-1-pirimidin-2-il-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-pirazin-2-il-4,5-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-piridin-2-il-4,5-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-pirazin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 6-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-2-metil-3-piridin-2-il-4,5,6,7-tetrahidro-2H-pirazolo[3,4c]piridin; TFA so 6-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-3-piridin-2-il-4,5,6,7-tetrahidro-2H-pirazolo[3,4-c]piridina; 6-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-3-(5-fluoropiridin-2-il)-4,5,6,7-tetrahidro-2H-pirazolo[3,4c]piridin; 6-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-3-(5-fluoropiridin-3-il)-4,5,6,7-tetrahidro-2H-pirazolo[3,4c]piridin; 6-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-3-piridin-3-il-4,5,6,7-tetrahidro-2H-pirazolo[3,4-c]piridin; 6-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-3-pirazin-2-il-4,5,6,7-tetrahidro-2H-pirazolo[3,4-c]piridin; 6-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-3-pirimidin-2-il-4,5,6,7-tetrahidro-2H-pirazolo[3,4-c]piridin; (2-Hloro-3-(trifluorometil)fenil)(3-fenil-4,5-dihidro-1H-pirazolo[3,4-c]piridin-6(7H)-il)metanon; 6-[(2,3-Dihlorofenil)karbonil]-3-fenil-4,5,6,7-tetrahidro-1H-pirazolo[3,4-c]piridin; 6-[(2,3-Dihlorofenil)karbonil]-1-metil-3-fenil-4,5,6,7-tetrahidro-1H-pirazolo[3,4-c]piridin i 6-[(2,3dihlorofenil)karbonil]-2-metil-3-fenil-4,5,6,7-tetrahidro-2H-pirazolo[3,4-c]piridin (1:1); 6-[(2,3-Dihlorofenil)karbonil]-2-metil-3-fenil-4,5,6,7-tetrahidro-2H-pirazolo[3,4-c]piridin; 6-[(2,3-Dihlorofenil)karbonil]-1-metil-3-fenil-4,5,6,7-tetrahidro-1H-pirazolo[3,4-c]piridin; 6-[(2,3-Dihloropiridin-4-il)karbonil]-3-fenil-4,5,6,7-tetrahidro-1H-pirazolo[3,4-c]piridin; 6-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-3-(4-fluorofenil)-2-metil-4,5,6,7-tetrahidro-2H-pirazolo[3,4-c]piridin; 6-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-3-(4-fluorofenil)-1-metil-4,5,6,7-tetrahidro-1H-pirazolo[3,4-c]piridin; 6-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-2-metil-3-piridin-3-il-4,5,6,7-tetrahidro-2H-pirazolo[3,4c]piridin; 6-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-metil-3-piridin-3-il-4,5,6,7-tetrahidro-1H-pirazolo[3,4c]piridin; 6-[(2,3-Dihlorofenil)karbonil]-3-(4-fluorofenil)-1-metil-4,5,6,7-tetrahidro-1H-pirazolo[3,4-c]piridin; 6-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-3-(4-fluorofenil)-4,5,6,7-tetrahidro-2H-pirazolo[3,4-c]piridin; 6-[(2,3-Dihlorofenil)karbonil]-2-metil-3-piridin-3-il-4,5,6,7-tetrahidro-2H-pirazolo[3,4-c]piridin; 6-[(2,3-Dihlorofenil)karbonil]-2-metil-3-piridin-3-il-4,5,6,7-tetrahidro-2H-pirazolo[3,4-c]piridin; 6-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-2-metil-3-pirimidin-5-il-4,5,6,7-tetrahidro-2H-pirazolo[3,4c]piridin; 6-[(2,3-Dihlorofenil)karbonil]-3-(4-fluorofenil)-4,5,6,7-tetrahidro-2H-pirazolo[3,4-c]piridin; 6-[(2,3-Dihlorofenil)karbonil]-3-piridin-4-il-4,5,6,7-tetrahidro-2H-pirazolo[3,4-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-6-metil-1-piridin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; (2-Hloro-4-fluorofenil)(1-(piridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-(S*)-6-metil-1-piridin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-(R*)-6-metil-1-piridin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-[(2,3-Dihlorofenil)karbonil]-6-metil-1-piridin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-[(2,3-Dihloro-4-fluorofenil)karbonil]-6-metil-1-piridin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-(3-fluoropiridin-2-il)-6-metil-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; (2-Fluoro-3-(trifluorometil)fenil)(1-(piridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-Fluoro-3-(trifluorometil)fenil)(1-(2-metoksifenil)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(2-metoksifenil)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(2-(2-fluoroetoksi)fenil)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(1-metil-1H-pirazol-3-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(1-metil-1H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (4-Hloro-2-fluorofenil)(1-(piridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2,3-Dihloro-4-fluorofenil)(1-(piridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(4-fluoropiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (3,4-Difluoro-2-metilfenil)(1-(piridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo-[4,5-c]piridin-5(4H)-il)metanon; (R*)-(2-Hloro-3-(trifluorometil)fenil)(4-metil-1-(1H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(2-Hloro-3-(trifluorometil)fenil)(4-metil-1-(1H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(6-fluoropiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; 2-Hloro-3-(trifluorometil)fenil)(1-(4-metoksipiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(6-fluoropiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(4-fluoropiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2,3-dihloro-4-fluorofenil)(4-metil-1-(piridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2,3-dihloro-4-fluorofenil)(4-metil-1-(pirazin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (R*)-(2,3-Dihloro-4-fluorofenil)(4-metil-1-(piridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (S*)-(2,3-Dihloro-4-fluorofenil)(4-metil-1-(piridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (R*)-(2,3-Dihloro-4-fluorofenil)(4-metil-1-(pirazin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (S*)-(2,3-Dihloro-4-fluorofenil)(4-metil-1-(pirazin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(5-metoksipiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (R*)-(2-hloro-3-(trifluorometil)fenil)(1-(6-fluoropiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (S*)-(2-Hloro-3-(trifluorometil)fenil)(1-(6-fluoropiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (R*)-(2-Hloro-3-(trifluorometil)fenil)(1-(4-fluoropiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (S*)-(2-Hloro-3-(trifluorometil)fenil)(1-(4-fluoropiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(4-metoksipiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (R*)-(2-Hloro-3-(trifluorometil)fenil)(1-(4-metoksipiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(2-Hloro-3-(trifluorometil)fenil)(1-(4-metoksipiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (6-metil-1-(1H-pirazol-3-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)(2-metil-3-(trifluorometil)fenil)metanon; (S*)-(4-hloro-2-fluorofenil)(1-(5-fluoropirimidin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (S)-(4-hloro-2-fluorofenil)(1-(5-fluoropirimidin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (S*)-(2-Hloro-3-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R)-(2-Hloro-3-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(1-(3,5-dimetilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (2,3-dihlorofenil)(1-(3,5-dimetilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2,3-Dihlorofenil)(1-(3-fluoropiridin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(1-(2-fluoroetil)-1H-pirazol-3-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(4-metil-1-(1-metil-1H-pirazol-3-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (S*)-(3-hloro-2-(trifluorometil)piridin-4-il)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (6R*)-5-[(2,3-Dihlorofenil)karbonil]-1-(3-fluoropiridin-2-il)-6-metil-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; (6S*)-5-[(2,3-Dihlorofenil)karbonil]-1-(3-fluoropiridin-2-il)-6-metil-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; (6R*)-5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-(3-fluoropiridin-2-il)-6-metil-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; (6S*)-5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-(3-fluoropiridin-2-il)-6-metil-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; (R*)-(2-Hloro-3-(trifluorometil)fenil)(4-metil-1-(1-metil-1H-pirazol-3-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(2-Hloro-3-(trifluorometil)fenil)(4-metil-1-(1-metil-1H-pirazol-3-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(2-Hloro-3-(trifluorometil)fenil)(1-(1-(2-fluoroetil)-1H-pirazol-3-il)-4-metil-6,7-dihidro1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(2-Hloro-3-(trifluorometil)fenil)(1-(1-(2-fluoroetil)-1H-pirazol-3-il)-4-metil-6,7-dihidro1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; 5-[(2,3-Dihlorofenil)karbonil]-1-(4-fluoropiridin-2-il)-6-metil-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5c]piridin; (2,3-Dihlorofenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2-fluoro-3-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(4-fluoropiridin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(4-metil-1-(pirimidin-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (S*)-(2-fluoro-3-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (2,3-dihlorofenil)(1-(4,6-dimetilpirimidin-2-il)-4-metil-6,7-dihidro-1 H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2,3-dihlorofenil)(4-metil-1-(6-metilpirazin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (R*)-(2-hloro-3-(trifluorometil)fenil)(1-(4,6-dimetilpirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(2-hloro-3-(trifluorometil)fenil)(1-(4,6-dimetilpirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(3-hloro-2-(trifluorometil)piridin-4-il)(1-(5-fluoropirimidin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(2-etil-4-metil-1-fenil-6,7-dihidro-1H-imidazo[4,5-c]piridin5(4H)-il)metanon; (R*)-(2-hloro-3-(trifluorometil)fenil)(4-metil-1-(4-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (S*)-(2-hloro-3-(trifluorometil)fenil)(4-metil-1-(4-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (S*)-(1-(5-fluoropirimidin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)(3-metil-2-(trifluorometil)piridin-4-il)metanon; (R*)-(4-metil-1-(pirimidin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)(2-metil-3-(trifluorometil)fenil)metanon; (2-fluoro-3-(trifluorometil)fenil)(6-metil-1-(1H-pirazol-3-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (R*)-(2-fluoro-3-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (S*)-(2,3-Dihlorofenil)(4-metil-1-(piridin-2-il)-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(2,3-Dihlorofenil)(4-metil-1-(piridin-2-il)-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(2-Hloro-3-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(2-Hloro-3-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (6R*)-5-[(2,3-Dihlorofenil)karbonil]-1-(4-fluoropiridin-2-il)-6-metil-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; (6S*)-5-[(2,3-Dihlorofenil)karbonil]-1-(4-fluoropiridin-2-il)-6-metil-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; (S*)-(4-metil-1-(pirimidin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)(2-metil-3-(trifluorometil)fenil)metanon; (6R*)-5-{[2-Hloro-3-(thifluorometil)fenil]karbonil}-1-(4-fluoropiridin-2-il)-6-metil-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; (6S*)-5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-(4-fluoropiridin-2-il)-6-metil-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-(5-fluoropirimidin-2-il)-6-metil-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; (6R*)-5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-(5-fluoropirimidin-2-il)-6-metil-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; (6S*)-5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-1-(5-fluoropirimidin-2-il)-6-metil-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; 5-[(2,3-Dihlorofenil)karbonil]-1-(5-fluoropirimidin-2-il)-6-metil-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5c]piridin; (6R*)-5-[(2,3-Dihlorofenil)karbonil]-1-(5-fluoropirimidin-2-il)-6-metil-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; (6S*)-5-[(2,3-Dihlorofenil)karbonil]-1-(5-fluoropihmidin-2-il)-6-metil-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 1-(5-Fluoropirimidin-2-il)-6-metil-5-{[2-metil-3-(trifluorometil)fenil]karbonil}-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; (6R*)-1-(5-Fluoropirimidin-2-il)-6-metil-5-{[2-metil-3-(trifluorometil)fenil]karbonil}-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; (6S*)-1-(5-Fluoropirimidin-2-il)-6-metil-5-{[2-metil-3-(trifluorometil)fenil]karbonil}-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; 5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-6-metil-1-pirazin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; (2-hloro-3-(trifluorometil)fenil)(6-metil-1-(1 H-pirazol-3-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (6R*)-5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-6-metil-1-pirazin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; (6S*)-5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-6-metil-1-pirazin-2-il-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; 5-[(2,3-Dihloro-4-fluorofenil)karbonil]-1-(5-fluoropirimidin-2-il)-6-metil-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; (6R*)-5-[(2,3-Dihloro-4-fluorofenil)karbonil]-1-(5-fluoropirimidin-2-il)-6-metil-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; (6S*)-5-[(2,3-Dihloro-4-fluorofenil)karbonil]-1-(5-fluoropirimidin-2-il)-6-metil-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; 5-[(2,4-Dihloro-3-fluorofenil)karbonil]-1-(5-fluoropirimidin-2-il)-6-metil-4,5,6,7-tetrahidro-1H-[1,2,3]triazolo[4,5-c]piridin; (6R*)-5-[(2,4-Dihloro-3-fluorofenil)karbonil]-1-(5-fluoropirimidin-2-il)-6-metil-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; (6S*)-5-[(2,4-Dihloro-3-fluorofenil)karbonil]-1-(5-fluoropirimidin-2-il)-6-metil-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; (6R)-1-(5-Fluoropirimidin-2-il)-5-{[2-fluoro-3-(trifluorometil)fenil]karbonil}-6-metil-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; (6S)-1-(5-Fluoropirimidin-2-il)-5-{[2-fluoro-3-(trifluorometil)fenil]karbonil}-6-metil-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; (6R*)-5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-6-metil-1-pirimidin-2-il-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; (6S*)-5-{[2-Hloro-3-(trifluorometil)fenil]karbonil}-6-metil-1-pirimidin-2-il-4,5,6,7-tetrahidro1H-[1,2,3]triazolo[4,5-c]piridin; (R*)-(2-hloro-3-(trifluorometil)fenil)(3-(5-fluoropirimidin-2-il)-7-metil-4,5-dihidro-2H-pirazolo[3,4-c]piridin-6(7H)-il)metanon; (S*)-(2-hloro-3-(trifluorometil)fenil)(3-(5-fluoropirimidin-2-il)-7-metil-4,5-dihidro-2H-pirazolo[3,4-c]piridin-6(7H)-il)metanon; (2,3-dihlorofenil)(4-metil-1-(4-metilpirimidin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (R*)-(2-hloro-3-(trifluorometil)fenil)(4-metil-1-(6-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (S*)-(2-hloro-3-(trifluorometil)fenil)(4-metil-1-(6-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (S)-(3-fluoro-2-(trifluorometil)piridin-4-il)(1-(5-fluoropirimidin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(3-fluoro-2-(trifluorometil)piridin-4-il)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(1-(5-fluoro-4-metilpirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2,3-dihlorofenil)(1-(4,6-dimetilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (S*)-(2-fluoro-5-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (2,3-dihlorofenil)(4-metil-1-(6-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (4R*)-(2-Hloro-3-(trifluorometil)fenil)((4R)-4-metil-1-(6-metil-1,6-dihidropirimidin-2-il)-6,7-dihidro1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (4R)-(2-Hloro-3-(trifluorometil)fenil)(4-metil-1-(4-metilpirimidin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(4-metil-1-(pirimidin-5-il)-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2,3-dihlorofenil)(4-metil-1-(4-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(4-fluorofenil)-4,7-dimetil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(2-hloro-3-(trifluorometil)fenil)(4-metil-1-(5-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5 c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(4,6-dimetil-1-fenil-6,7-dihidro-1 H-[1,2,3]triazolo[4,5-c]piridin¬5(4H)-il)metanon; (2-Hloro-3-(trifluoromethyl)fenil)(4,7-dimetil-1-fenil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin¬5(4H)-il)metanon; (2,3-Dihlorofenil)(1-(4-fluorofenil)-4,6-dimetil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(4-fluorofenil)-4,6-dimetil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2,3-Dihlorofenil)(7-metil-1-fenil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(7-metil-1-fenil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(4-fluorofenil)-7-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2,3-Dihlorofenil)(1-(4-fluorofenil)-7-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(2-Hloro-3-(trifluorometil)fenil)(1-(1-(2-metoksietil)-1H-pirazol-3-il)-4-metil-6,7-dihidro1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(2-Hloro-3-(trifluorometil)fenil)(1-(1-(2-metoksietil)-1H-pirazol-3-il)-4-metil-6,7-dihidro1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(4-metil-1-(oksazol-2-il)-6,7-dihidro-1 H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(4-metil-1-(6-metilpirazin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(4-metil-1-(4-metilpirimidin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(4,6-dimetilpirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(3-etilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(2-hloro-3-(trifluorometil)fenil)(4-metil-1-(5-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (2-hloro-4-fluorofenil)(1-(5-fluoropiridin-2-il)-4-metil-6,7-dihidro-1H-imidazo[4,5-c]piridin5(4H)-il)metanon; (2,4-dihlorofenil)(1-(pirimidin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(3-etoksipiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(4-metil-1-(3-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(3-metoksipiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (2,3-dihloro-4-fluorofenil)(1-(5-fluoropiridin-2-il)-4-metil-6,7-dihidro-1H-imidazo[4,5-c]piridin5(4H)-il)metanon; (2-fluoro-3-(trifluorometil)fenil)(1-(5-fluoropiridin-2-il)-4-metil-6,7-dihidro-1H-imidazo[4,5-c]piridin5(4H)-il)metanon; ( 1-(5-fluoropiridin-2-il)-4-metil-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)(2-metil-3-(trifluorometil)fenil)metanon; (2-fluorofenil)(1-(5-fluoropiridin-2-il)-4-metil-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (4-(terc-butil)fenil)(1-(5-fluoropiridin-2-il)-4-metil-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(1,5-dimetil-3-(1-metil-1H-pirazol-5-il)-4,5-dihidro-1H-pirazolo[3,4c]piridin-6(7H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(5-metil-3-(1H-pirazol-5-il)-4,5-dihidro-1H-pirazolo[3,4-c]piridin6(7H)-il)metanon; (2,4-dihlorofenil)(5-metil-3-(1H-pirazol-5-il)-4,5-dihidro-1H-pirazolo[3,4-c]piridin-6(7H)-il)metanon; (2-fluoro-3-(trifluorometil)fenil)(4-metil-1-(4-metilpirimidin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (S*)-(2-fluoro-3-(trifluorometil)fenil)(4-metil-1-(pirimidin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(2-fluoro-3-(trifluorometil)fenil)(4-metil-1-(pirimidin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (4-hloro-2-fluorofenil)(1-(pirazin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-fluoro-3-(trifluorometil)fenil)(4-metil-1-(pirazin-2-il)-6,7-dihidro-1 H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (4-hloro-2-fluorofenil)(4-metil-1-(pirazin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (4-hloro-2-fluorofenil)(4-metil-1-(pirimidin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2-metil-3-(trifluorometil)fenil)(1-(pirazin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2,4-dihlorofenil)(1-(pirazin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (4-metil-1-(pirazin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)(2-metil-3-(trifluorometil)fenil)metanon; (2,4-dihlorofenil)(4-metil-1-(pirazin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (4-hloro-2-fluorofenil)(1-(pirimidin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-metil-3-(trifluorometil)fenil)(1-(pirimidin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (4-metil-1-(pirimidin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)(2-metil-3-(trifluorometil)fenil)metanon; (2,4-dihlorofenil)(4-metil-1-(pirimidin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)((4R,6R)-1-(4-fluorofenil)-4,6-dimetil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)((4S,6S)-1-(4-fluorofenil)-4,6-dimetil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; 2-hloro-3-(trifluorometil)fenil)((4S,6R)-1-(4-fluorofenil)-4,6-dimetil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)((4R,6S)-1-(4-fluorofenil)-4,6-dimetil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(2-hloro-3-(trifluorometil)fenil)(6-metil-1-fenil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(4-metil-3-fenil-6,7-dihidro-3H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(6-metil-1-fenil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (R*)-(2-hloro-3-(trifluorometil)fenil)(4-metil-1-(3-metilpiridin-2-il)-6,7-dihidro-1 H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (S*)-(2-hloro-3-(trifluorometil)fenil)(4-metil-1-(3-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(4-metil-1-(3-propoksipiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(2-hloro-3-(trifluorometil)fenil)(1-(4-etilpirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (1-(3-etilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)(3-(trifluorometil)fenil)metanon; (2-hloro-3-(trifluorometil)fenil)((4R,6R)-4,6-dimetil-1-(1H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)((4S,6R)-4,6-dimetil-1-(1H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; 2-hloro-3-(trifluorometil)fenil)(4,6-dimetil-1-(1H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(4-metil-1-(4-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(1-(4,6-dimetilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(4-metil-1-(5-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(4-metil-1-(6-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(3-(5-fluoropirimidin-2-il)-7-metil-2-((2-(trimetilsilil)etoksi)metil)4,5-dihidro-2H-pirazolo[3,4-c]piridin-6(7H)-il)metanon; (S)-(1-(5-fluoropirimidin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)(3-(trifluorometil)fenil)metanon; (R*)-(2-hloro-3-(trifluorometil)fenil)(1-(5-fluoro-4-metilpirimidin-2-il)-4-metil-6,7-dihidro1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(2-hloro-3-(trifluorometil)fenil)(1-(5-fluoro-4-metilpirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(3-fluoro-5-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(7-metil-3-(trifluorometil)-4,5-dihidro-1H-pirazolo[3,4-c]piridin6(7H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)((4S,6R)-4,6-dimetil-1-(1H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)((4R,6S)-4,6-dimetil-1-(1H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-fluoro-3-(trifluorometil)fenil)(1-(5-fluoropirimidin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (1-(5-fluoropiridin-2-il)-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)(2-metil-3-(trifluorometil)fenil)metanon; (2,4-dihlorofenil)(1-(5-fluoropiridin-2-il)-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (2-fluoro-3-(trifluorometil)fenil)(1(5-fluoropiridin-2-il)-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(1-(5-fluoropiridin-2-il)-6,7-dihidro-1 H-imidazo[4,5-c]piridin5(4H)-il)metanon; (R*)-(2-hloro-3-(trifluorometil)fenil)(1-(3-etoksipiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (S*)-(2-hloro-3-(trifluorometil)fenil)(1-(3-etoksipiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (S*)-(2-hloro-3-(trifluorometil)fenil)(1-(1-(2-hidroksietil)-1H-pirazol-3-il)-4-metil-6,7-dihidro1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)((4S,6S)-4,6-dimetil-1-(1H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)((4R,6R)-4,6-dimetil-1-(1H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(1-(5-fluoropiridin-2-il)-4-metil-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (3-fenil-4,5-dihidro-1H-pirazolo[3,4-c]piridin-6(7H)-il)(2-(trifluorometil)piridin-3-il)metanon; (2-hloro-4-fluorofenil)(3-fenil-4,5-dihidro-1H-pirazolo[3,4-c]piridin-6(7H)-il)metanon; (2,6-dihlorofenil)(3-fenil-4,5-dihidro-1H-pirazolo[3,4-c]piridin-6(7H)-il)metanon; (2-hloro-6-fluorofenil)(3-fenil-4,5-dihidro-1H-pirazolo[3,4-c]piridin-6(7H)-il)metanon; (2,3-dihlorofenil)(3-(4-fluorofenil)-2-metil-4,5-dihidro-2H-pirazolo[3,4-c]piridin-6(7H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(2-metil-3-(piridin-4-il)-4,5-dihidro-2H-pirazolo[3,4-c]piridin6(7H)-il)metanon; (2,3-dihlorofenil)(2-metil-3-(piridin-4-il)-4,5-dihidro-2H-pirazolo[3,4-c]piridin-6(7H)-il)metanon; (2,3-dihlorofenil)(2-metil-3-(pirimidin-5-il)-4,5-dihidro-2H-pirazolo[3,4-c]piridin-6(7H)-il)metanon; (2,3-dihlorofenil)(3-(pirimidin-5-il)-4,5-dihidro-2H-pirazolo[3,4-c]piridin-6(7H)-il)metanon; (2,3-dihlorofenil)(2-metil-1-fenil-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (2,3-dihlorofenil)(2-etil-1-fenil-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(2-hloro-3-(trifluorometil)fenil)(4-metil-1-(pirimidin-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(2-hloro-3-(trifluorometil)fenil)(4-metil-1-(pirimidin-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2,3-dihlorofenil)(4-metil-1-(5-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (R*)-(3-hloro-4-(trifluorometil)piridin-2-il)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(4-hloro-5-(trifluorometil)piridin-3-il)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(3-hloro-2-(trifluorometil)piridin-4-il)(1-(5-fluoropirimidin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(3-hloro-4-(trifluorometil)piridin-2-il)(4-metil-1-(pirazin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(4-hloro-5-(trifluorometil)piridin-3-il)(4-metil-1-(pirazin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(3-hloro-2-(trifluorometil)piridin-4-il)(4-metil-1-(pirazin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-Hloro-3-(trifluorometil)fenil)(1-(piridin-2-il)-6,7-dihidro-1H-imidazo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(6-methy-1-(1H-pirazol-3-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)(2-metil-3-(trifluorometil)fenil)metanon; (S*)-(6-metil-1-(1H-pirazol-3-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)(2-metil-3-(trifluorometil)fenil)metanon; (R*)-(2-fluoro-3-(trifluorometil)fenil)(6-metil-1-(1H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(2-fluoro-3-(trifluorometil)fenil)(6-metil-1-(1H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(2-hloro-3-(trifluorometil)fenil)(6-metil-1-(1H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(2-hloro-3-(trifluorometil)fenil)(6-metil-1-(H-pirazol-5-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-hloro-5-(trifluorometil)fenil)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(2-hloro-5-(trifluorometil)fenil)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(2-hloro-5-(trifluorometil)fenil)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (3-fluoro-2-(trifluorometil)piridin-4-il)(4-metil-1-(4-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (R*)-(3-fluoro-2-(trifluorometil)piridin-4-il)(4-metil-1-(4-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(3-fluoro-2-(trifluorometil)piridin-4-il)(4-metil-1-(4-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (3-hloro-2-(trifluorometil)piridin-4-il)(4-metil-1-(4-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (R*)-(3-hloro-2-(trifluorometil)piridin-4-il)(4-metil-1-(4-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(3-hloro-2-(trifluorometil)piridin-4-il)(4-metil-1-(4-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (3-hloro-5-(trifluorometil)fenil)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(3-hloro-5-(trifluorometil)fenil)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(3-hloro-5-(trifluorometil)fenil)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (4-hloro-3-(trifluorometil)fenil)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(4-hloro-3-(trifluorometil)fenil)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(4-hloro-3-(trifluorometil)fenil)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (3-fluoro-2-(trifluorometil)piridin-4-il)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(3-fluoro-2-(trifluorometil)piridin-4-il)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(3-fluoro-2-(trifluorometil)piridin-4-il)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (3-hloro-2-(trifluorometil)piridin-4-il)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(3-hloro-2-(trifluorometil)piridin-4-il)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(3-hloro-2-(trifluorometil)piridin-4-il)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-fluoro-3-(trifluorometoksi)fenil)(4-metil-1-(4-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-fluoro-3-(trifluorometoksi)fenil)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (4-metil-1-(4-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)(3-(trifluorometoksi)fenil)metanon; (R*)-(4-metil-1-(4-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)(3-(trifluorometoksi)fenil)metanon; (S*)-(4-metil-1-(4-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)(3-(trifluorometoksi)fenil)metanon; (2-hloro-3-(trifluorometil)fenil)(4-metil-1-(6-(trifluorometil)piridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(2-hloro-3-(trifluorometil)fenil)(4-metil-1-(6-(trifluorometil)piridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(2-hloro-3-(trifluorometil)fenil)(4-metil-1-(6-(trifluorometil)piridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; R*)-(2-hloro-3-(trifluorometil)fenil)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S*)-(2-hloro-3-(trifluorometil)fenil)(1-(5-fluoro-4-metilpiridin-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (1-(1H-imidazol-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)(2,3-dihlorofenil)metanon; (2-fluoro-3-(trifluorometil)fenil)(4-metil-1-(6-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (R*)-(2-fluoro-3-(trifluorometil)fenil)(4-metil-1-(6-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (S*)-(2-fluoro-3-(trifluorometil)fenil)(4-metil-1-(6-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5 c]pyridin-5(4H)-il)metanon; (3-Hloro-2-metilfenil)(4-methyl-1-(4-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin¬5(4H)-il)metanon; (R*)-(2,3-dihlorofenil)(4-metil-1-(6-metilpiridin-2-il)-6,7-dihidro-1 H-[1,2,3]triazolo[4,5-c]piridin¬ 5(4H)-il)metanon; (S*)-(2,3-dihlorofenil)(4-metil-1-(6-metilpiridin-2-il)-6,7-dihidro-1 H-[1,2,3]triazolo[4,5-c]pyridin¬ 5(4H)-il)metanon; (R*)-(2,3-dihlorofenil)(4-metil-1 -(4-metilpirimidin-2-il)-6,7-dihidro-1 H-[1,2,3]triazolo[4,5-c]piridin¬5(4H)-il)metanon; (S*)-(2,3-dihlorofenil)(4-metil-1-(4-metilpirimidin-2-il)-6,7-dihidro-1 H-[1,2,3]triazolo[4,5-c]piridin¬5(4H)-il)metanon; (1-(1H-imidazol-2-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)(2-hloro-3-(trifluorometil)fenil)metanon; (R*)-(2,3-dihlorofenil)(4-metil-1-(4-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (S*)-(2,3-dihlorofenil)(4-metil-1-(4-metilpiridin-2-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (2-fluoro-3-(trifluorometil)fenil)(4-metil-1-(6-metilpirimidin-4-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (3-fluoro-2-(trifluorometil)piridin-4-il)(4-metil-1-(6-metilpirimidin-4-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(4-metil-1-(2-metilpirimidin-4-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (3-hloro-2-(trifluorometil)piridin-4-il)(4-metil-1-(2-metilpirimidin-4-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-fluoro-3-(trifluorometil)fenil)(4-metil-1-(2-metilpirimidin-4-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (3-fluoro-2-(trifluorometil)piridin-4-il)(4-metil-1-(2-metilpirimidin-4-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(4-metil-1-(6-metilpirimidin-4-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (3-hloro-2-(trifluorometil)piridin-4-il)(4-metil-1-(6-metilpirimidin-4-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(2-hloro-3-(trifluorometil)fenil)(1-(1-etil-1H-pirazol-3-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(2-hloro-3-(trifluorometil)fenil)(1-(1-etil-1H-pirazol-3-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(2-hloro-3-(trifluorometil)fenil)(1-(1-etil-1H-pirazol-5-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(2-hloro-3-(trifluorometil)fenil)(1-(1-etil-1H-pirazol-5-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(1-(1-etil-1H-pirazol-3-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)(3-fluoro-2-(trifluorometil)piridin-4-il)metanon; (S)-(1-(1-etil-1H-pirazol-3-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)(3-fluoro-2-(trifluorometil)piridin-4-il)metanon; (S)-(3-hloro-2-(trifluorometil)piridin-4-il)(1-(1-etil-1H-pirazol-3-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(3-hloro-2-(trifluorometil)piridin-4-il)(1-(1-etil-1H-pirazol-3-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(2-hloro-3-(trifluorometil)fenil)(1-(1-izopropil-1H-pirazol-3-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(2-hloro-3-(trifluorometil)fenil)(1-(1-izopropil-1H-pirazol-3-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(2-fluoro-3-(trifluorometil)fenil)(1-(1-izopropil-1H-pirazol-3-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(2-fluoro-3-(trifluorometil)fenil)(1-(1-izopropil-1H-pirazol-3-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(3-hloro-2-(trifluorometil)piridin-4-il)(1-(1-izopropil-1H-pirazol-3-il)-6-metil-6,7-dihidro1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(3-hloro-2-(trifluorometil)piridin-4-il)(1-(1-izopropil-1H-pirazol-3-il)-4-metil-6,7-dihidro1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(3-fluoro-2-(trifluorometil)piridin-4-il)(1-(1-izopropil-1H-pirazol-3-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(3-fluoro-2-(trifluorometil)piridin-4-il)(1-(1-izopropil-1H-pirazol-3-il)-4-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(2-hloro-3-(trifluorometil)fenil)(6-metil-1-(tiofen-3-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (S)-(2-hloro-3-(trifluorometil)fenil)(4-metil-1-(tiofen-3-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin5(4H)-il)metanon; (S*)-(3-hloro-2-(trifluorometil)piridin-4-il)(6-metil-1-(1H-pirazol-3-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (S*)-(3-hloro-2-(trifluorometil)piridin-4-il)(4-metil-1-(1H-pirazol-3-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (S*)-(3-fluoro-2-(trifluorometil)piridin-4-il)(6-metil-1-(1H-pirazol-3-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (S*)-(3-fluoro-2-(trifluorometil)piridin-4-il)(4-metil-1-(1H-pirazol-3-il)-6,7-dihidro-1H-[1,2,3]triazolo[4,5c]piridin-5(4H)-il)metanon; (S)-(1-(5-fluoropirimidin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)(2-hidroksi-3-(trifluorometil)fenil)metanon; (S)-(2-fluoro-3-(trifluorometoksi)fenil)(1-(5-fluoropirimidin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(2-fluoro-3-(trifluorometil)fenil)(1-(5-hidroksipirimidin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (S)-(3-fluoro-2-(trifluorometil)piridin-4-il)(1-(5-hidroksipirimidin-2-il)-6-metil-6,7-dihidro-1H-[1,2,3]triazolo[4,5-c]piridin-5(4H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(3-(5-fluoropiridin-2-il)-7-metil-4,5-dihidro-2H-pirazolo[3,4-c]piridin6(7H)-il)metanon; (2,3-dihlorofenil)(7-metil-3-(pirimidin-2-il)-4,5-dihidro-2H-pirazolo[3,4-c]piridin-6(7H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(7-metil-3-(piridin-2-il)-4,5-dihidro-2H-pirazolo[3,4-c]piridin6(7H)-il)metanon; (2,3-dihlorofenil)(7-metil-3-(pirazin-2-il)-4,5-dihidro-2H-pirazolo[3,4-c]piridin-6(7H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(3-(4-fluorofenil)-7-metil-4,5-dihidro-2H-pirazolo[3,4-c]piridin6(7H)-il)metanon; (2,3-dihlorofenil)(3-(4-fluorofenil)-7-metil-4,5-dihidro-2H-pirazolo[3,4-c]piridin-6(7H)-il)metanon; (2,3-dihlorofenil)(7-metil-3-(1-metil-1H-pirazol-5-il)-4,5-dihidro-2H-pirazolo[3,4-c]piridin6(7H)-il)metanon; (2-hloro-3-(trifluorometil)fenil)(7-metil-3-(1-metil-1H-pirazol-5-il)-4,5-dihidro-2H-pirazolo[3,4-c]piridin-6(7H)-il)metanon; i (2-hloro-3-(trifluorometil)fenil)(7-metil-3-(pirazin-2-il)-4,5-dihidro-2H-pirazolo[3,4-c]piridin6(7H)-il)metanon.
13. Farmaceutska kompozicija, koja sadrži: (a) terapeutski efikasna količina bar jednog jedinjenja nezavisno izabranog između jedinjenja iz zahteva 1, jedinjenja iz zahteva 8, i jedinjenja iz zahteva 12; (b) bar jednog farmaceutski prihvatljivog ekscipijenta.
14. Jedinjenje prema 1 ili zahtevu 8 za upotrebu u postupku lečenja subjekta koji ima ili kod koga je dijagnozirana bolest, poremećaj ili medicinsko stanje koje je posredovano aktivnošću receptora P2X7, koje obuhvata davanje subjektu kome je potreban taj tretman efikasne količine bar jednog jedinjenja izabranog između jedinejnja prema zahtevu 1 ili zahtevu 8.
15. Jedinjenje prema zathevu 1 ili zahtevu 8 za upotrebu u zahtevu 14, gde bolest poremećaj ili medicinsko stanje je izabrano iz grupe koju čine: reumatoidni artritis, osteoartritis, psorijaza, septički šok, alergijski dermatitis, astma, alergijska astma, blaga do ozbiljna astma, astma rezistentna na stereoide, idiopatska plućna fibroza, alergijski rinitis, hronična obstruktivna bolest pluća; povećana osetljivost disajnih puteva, bolesti nervnog i neuroimunog sistema, akutna i hronična stanja neuropastkog bola, zapaljenski bol, spontani bol, bol izazvan opijatima, dijabetična neuropatija, postherpesna neuralgija, neuropatski bol izazvan hemoterapijom, fibromijalgija, bolesti koje obuhvataju ili ne neuroinflamacije centralnog nervnog sistema, poremećaje raspoloženja, depresiju major, poremećaj depresije major, terapijski rezistentna depresija, bipolarni poremećaj, anksiozna depresija, anksioznost, spoznaja, poremećaji spavanja, multiple sklerozu, epileptične napade, Parkisonova bolest, šizofrenija, Alchajmerova bolest, Hantignotonova bolest, autizam povreda kičmene moždine i cerebralna ishemija/traumatske povrede mozga, poremećaji u vezi sa stresom, kardiovaskularne bolesti, metaboličke, gastrointestinalne bolesti i bolesti urogenitalnog sistema kao što su diabetes, diabetes mellitus, tromboza, sindrom nervoznih creva, bolest nervnoznih creva, Kronova bolest, ishemijska bolest srca, ishemija, hipertenzija, kardiovaskularna bolest, infarkt miokarda, i disfunkcija donjeg urinarnog trakta kao što su inkontinenca, sindrom donjeg urinarnog trakta, bolest policističnih bubrega, glomerulonefritis, poremećaji skeleta, osteoporoza, osteopetroza, i glaukom, intersticijalnil cistitis, kašalj, ureteričma opstrukcija, sepsa, amiotrofna lateralna skleroza, Šagasova bolest, klamidija, neuroblastom, tuberkuloza, i migrena, ili gde je bolest, poremećaj ili medicinsko stanje terapijski rezistentna depresija.
16. Postupak za dobijanje jedinjenja formule Formula (I) gde je R1 (a) fenil, opciono supstituisan sa nula do četiri grupe nezavisno izabrane iz grupe koju čine halo, C1-C4alkil, alkoksi, perhaloalkil i perhaloalkoksi; ili (b) heteroaril, nezavisno izabran iz grupe koju čine: i gde Rk je nezavisno izabran iz grupe koju čine H, halo, C1-C3alkil, hidroksil, perhaloalkil i alkoksi; Rj je nezavisno izabran između H ili C1-C3alkil gde C1-C3alkil je opciono supstituisan sa jedan do tri halo supstituenta, jednim OH supstituentom ili jednim alkoksi supstituentom; i n je ceo broj od 0-3; X je N ili CR2; R2 je H, perhaloalkil ili C1-C3 niži alkil; R3 je H, perhaloalkil, C1-C4 alkil, alkalkoksi, CH2Ri, -C(O)Re ili fenil, gde pomenuti fenil je opciono supstituisan sa nula do dve nezavisno izabran iz grupe koju čine halo, C1-C3alkil, alkoksi, perhaloalkil i perhaloalkoksi; Ri je OH, NC3H6, N(C1-C3alkil)2 ili halo; Re je OH, OC1-C3 alkil, N(C1-C3alkil)2, ili NC3H6; R4 i R5 su nezavisno H ili C1-C3 alkil; R8 je fenil ili piridil, opciono supstituisan sa nula do četiri Rm supstituenta gde Rm je nezavisno izabran iz grupe koju čine halo, C1-C3alkil, hidroksi, alkoksi, perhaloalkil i perhaloalkoksi; ili R8 je nezavisno izabran iz grupe koju čine: i i farmaceutski prihvatljivih soli jedinjenja formule (I) obuhvata korake: (a) reagovanje jedinjenja XXIVA sa izvorom azida, alkilacionim sredstvom, prvom bazom i soli bakra (I) u prvom organskom rastvaraču na temperaturi od oko -78 °C, da bi se obrazovalo jedinjenje XXVA; (b) reagovanje jedinjenja XXVA sa ozonom u drugom organskom rastvaraču izabranom iz grupe koju čine : metanol, dihlorometan i tetrahidrofuran, na temperaturi od oko -78 °C, i zatim tretiranje reakcione smeše sa NaBH4 da bi se obrazovalo jedinjenje XXVIA; (c) reagovanje jedinjenja XXVIA sa sulfonil hloridom u trećem organskom rastvaraču, drugoj bazi, i alkilacionim katalizatorom, da bi se obrazovalo jedinjenje XXVIIA; i (d) reagovanje jedinejnja XXVIIA u četvrtom rastvaraču, sa trećom bazom na temperaturi od oko 60 °C u toku približno 3 sata da bi se obrazovalo jedinjenje formule (I). Položaj [°2 teta ] (bakar (Cu)) Signali SLIKA 1 Položaj [°2 teta ] (bakar (Cu)) SLIKA 2 Signali
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WO2014152604A1 (en) 2014-09-25
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AU2017206153B2 (en) 2019-02-14
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US10703749B2 (en) 2020-07-07
AU2019203186B2 (en) 2021-06-24
BR112015023142B1 (pt) 2023-05-02
AR123048A2 (es) 2022-10-26
EP2970267A1 (en) 2016-01-20
US20200325138A1 (en) 2020-10-15
US20160039809A1 (en) 2016-02-11
CN105209464A (zh) 2015-12-30
ES2635318T3 (es) 2017-10-03
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AU2021236451A1 (en) 2021-10-14
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US20240116930A1 (en) 2024-04-11
JP6293861B2 (ja) 2018-03-14
KR20250004140A (ko) 2025-01-07
TW201740940A (zh) 2017-12-01
BR112015023142A2 (pt) 2017-07-18
CN110003200B (zh) 2021-11-26
AU2019203186A1 (en) 2019-05-30
US11225478B2 (en) 2022-01-18
US10112937B2 (en) 2018-10-30
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US20190092770A1 (en) 2019-03-28
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