AR095530A1 - Moduladores de p2x7 - Google Patents
Moduladores de p2x7Info
- Publication number
- AR095530A1 AR095530A1 ARP140101138A ARP140101138A AR095530A1 AR 095530 A1 AR095530 A1 AR 095530A1 AR P140101138 A ARP140101138 A AR P140101138A AR P140101138 A ARP140101138 A AR P140101138A AR 095530 A1 AR095530 A1 AR 095530A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- independently selected
- perhaloalkyl
- halo
- Prior art date
Links
- 102100037602 P2X purinoceptor 7 Human genes 0.000 title 1
- 101710189965 P2X purinoceptor 7 Proteins 0.000 title 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 9
- 125000001475 halogen functional group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
La presente se refiere, además, a las composiciones farmacéuticas que comprenden los compuestos de las fórmulas (1, 1a, 2a y 2b). Los métodos para preparar y para usar los compuestos de las fórmulas (1, 1a, 2a y 2b) se encuentran, además, dentro del alcance de la presente. Enfermedades autoinmunes. Reivindicación 1: Un compuesto de la fórmula (1), en donde R¹ es (a) fenilo, opcionalmente sustituido con cero a cuatro grupos independientemente seleccionados del grupo que consiste en halo, alquilo C₁₋₄, alcoxi, perhaloalquilo y perhaloalcoxi; o (b) heteroarilo, independientemente seleccionado del grupo que consiste en los restos del grupo de fórmulas (3); en donde Rᵏ se selecciona, independientemente, del grupo que consiste en H, halo, alquilo C₁₋₃, hidroxilo, perhaloalquilo y alcoxi; Rʲ se selecciona, independientemente, de H o alquilo C₁₋₃, en donde el alquilo C₁₋₃ está opcionalmente sustituido con uno a tres sustituyentes halo, uno sustituyente OH o uno sustituyente alcoxi; y n es un entero de 0 - 3; X es N o CR²; R² es H, perhaloalquilo o alquilo inferior C₁₋₃; R³ es H, perhaloalquilo, alquilo C₁₋₄, alcalcoxi, CH₂Rⁱ, -C(O)Rᵉ o fenilo, en donde el fenilo está opcionalmente sustituido con cero a dos grupos independientemente seleccionados del grupo que consiste en halo, alquilo C₁₋₃, alcoxi, perhaloalquilo y perhaloalcoxi; Rⁱ es OH, NC₃H₆, N(alquilo C₁₋₃)₂ o halo; Rᵉ es OH, O-alquilo C₁₋₃, N(alquilo C₁₋₃)₂, o NC₃H₆; R⁴ y R⁵ son independientemente H o alquilo C₁₋₃; R⁸ es fenilo o piridilo, opcionalmente sustituido con cero a cuatro sustituyentes Rᵐ en donde Rᵐ se selecciona, independientemente, del grupo que consiste en halo, alquilo C₁₋₃, hidroxi, alcoxi, perhaloalquilo y perhaloalcoxi; o R⁸ se selecciona, independientemente, del grupo que consiste en los restos del grupo de fórmulas (4); y sales aceptables farmacéuticamente de compuestos de la fórmula (1).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361786260P | 2013-03-14 | 2013-03-14 |
Publications (1)
Publication Number | Publication Date |
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AR095530A1 true AR095530A1 (es) | 2015-10-21 |
Family
ID=50543353
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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ARP140101138A AR095530A1 (es) | 2013-03-14 | 2014-03-14 | Moduladores de p2x7 |
ARP210102071A AR123048A2 (es) | 2013-03-14 | 2021-07-23 | Moduladores de p2x7 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP210102071A AR123048A2 (es) | 2013-03-14 | 2021-07-23 | Moduladores de p2x7 |
Country Status (33)
Country | Link |
---|---|
US (8) | US10112937B2 (es) |
EP (3) | EP3495365A1 (es) |
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