PE20211773A1 - Moduladores de monoacilglicerol lipasa - Google Patents

Moduladores de monoacilglicerol lipasa

Info

Publication number
PE20211773A1
PE20211773A1 PE2021000405A PE2021000405A PE20211773A1 PE 20211773 A1 PE20211773 A1 PE 20211773A1 PE 2021000405 A PE2021000405 A PE 2021000405A PE 2021000405 A PE2021000405 A PE 2021000405A PE 20211773 A1 PE20211773 A1 PE 20211773A1
Authority
PE
Peru
Prior art keywords
monacilglycerol
disorders
lipase
modulators
lipase modulators
Prior art date
Application number
PE2021000405A
Other languages
English (en)
Inventor
Michael K Ameriks
Gang Chen
Chaofeng Huang
Brian Ngo Laforteza
Suchitra Ravula
Emma Helen Southgate
Wei Zhang
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PE20211773A1 publication Critical patent/PE20211773A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Un compuesto de formula (I) donde R2 es pirazol, R3 es fenilo, R4 es alquilo. Composiciones farmaceuticas que los contienen, metodos para fabricarlos. Asi mismo, son utiles para tratar estados de enfermedad, trastornos y afecciones asociados con la modulacion de la MGL, tales como aquellos asociados con dolor, trastornos psiquiatricos, trastornos neurologicos.
PE2021000405A 2018-09-28 2019-09-27 Moduladores de monoacilglicerol lipasa PE20211773A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862738600P 2018-09-28 2018-09-28
PCT/IB2019/058240 WO2020065613A1 (en) 2018-09-28 2019-09-27 Monoacylglycerol lipase modulators

Publications (1)

Publication Number Publication Date
PE20211773A1 true PE20211773A1 (es) 2021-09-08

Family

ID=68109428

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2021000405A PE20211773A1 (es) 2018-09-28 2019-09-27 Moduladores de monoacilglicerol lipasa

Country Status (22)

Country Link
US (3) US20200102303A1 (es)
EP (1) EP3856178A1 (es)
KR (1) KR20210069080A (es)
CN (1) CN113164459A (es)
AU (1) AU2019350624A1 (es)
BR (1) BR112021005896A2 (es)
CA (1) CA3111380A1 (es)
CL (1) CL2021000757A1 (es)
CO (1) CO2021003944A2 (es)
CR (1) CR20210153A (es)
EA (1) EA202190886A1 (es)
EC (1) ECSP21021381A (es)
IL (1) IL281812A (es)
JO (1) JOP20210058A1 (es)
MA (1) MA53721A (es)
MX (1) MX2021003737A (es)
NI (1) NI202100023A (es)
PE (1) PE20211773A1 (es)
PH (1) PH12021550659A1 (es)
SG (1) SG11202102281VA (es)
TW (1) TW202028198A (es)
WO (1) WO2020065613A1 (es)

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JO3773B1 (ar) 2013-03-14 2021-01-31 Janssen Pharmaceutica Nv معدلات p2x7
EP3856179A1 (en) 2018-09-28 2021-08-04 Janssen Pharmaceutica N.V. Monoacylglycerol lipase modulators
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US11839663B2 (en) 2019-09-30 2023-12-12 Janssen Pharmaceutica Nv Radiolabelled MGL pet ligands
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WO2022150962A1 (en) * 2021-01-12 2022-07-21 Westlake Pharmaceutical (Hangzhou) Co., Ltd. Protease inhibitors, preparation, and uses thereof
WO2023110958A1 (en) 2021-12-16 2023-06-22 F. Hoffmann-La Roche Ag Bicyclic heterocyclic compounds useful as monoacylglycerol lipase inhibitors

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Also Published As

Publication number Publication date
EA202190886A1 (ru) 2021-09-07
US20200102303A1 (en) 2020-04-02
BR112021005896A2 (pt) 2021-07-27
EP3856178A1 (en) 2021-08-04
JP2022502424A (ja) 2022-01-11
KR20210069080A (ko) 2021-06-10
US20220332713A1 (en) 2022-10-20
CL2021000757A1 (es) 2021-08-27
WO2020065613A1 (en) 2020-04-02
CA3111380A1 (en) 2020-04-02
MA53721A (fr) 2021-09-15
CN113164459A (zh) 2021-07-23
NI202100023A (es) 2021-09-07
AU2019350624A1 (en) 2021-03-18
MX2021003737A (es) 2021-05-14
JOP20210058A1 (ar) 2021-03-24
CR20210153A (es) 2021-05-11
US11820766B2 (en) 2023-11-21
CO2021003944A2 (es) 2021-04-19
ECSP21021381A (es) 2021-04-29
PH12021550659A1 (en) 2022-02-21
IL281812A (en) 2021-05-31
SG11202102281VA (en) 2021-04-29
US20230145249A1 (en) 2023-05-11
TW202028198A (zh) 2020-08-01

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