MX2021013197A - Cicloalquilos sustituidos como moduladores de la vía integrada del estrés. - Google Patents

Cicloalquilos sustituidos como moduladores de la vía integrada del estrés.

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Publication number
MX2021013197A
MX2021013197A MX2021013197A MX2021013197A MX2021013197A MX 2021013197 A MX2021013197 A MX 2021013197A MX 2021013197 A MX2021013197 A MX 2021013197A MX 2021013197 A MX2021013197 A MX 2021013197A MX 2021013197 A MX2021013197 A MX 2021013197A
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MX
Mexico
Prior art keywords
modulators
integrated stress
substituted cycloalkyls
stress pathway
pathway
Prior art date
Application number
MX2021013197A
Other languages
English (en)
Inventor
John T Randolph
Lei Shi
Michael J Dart
Yunsong Tong
Xiangdong Xu
Carmela Sidrauski
Hanae Benelkebir
Kathleen Ann Martin
Kathleen J Murauski
Steven Edeson
Kathryn Starbuck
Original Assignee
Calico Life Sciences Llc
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Publication date
Application filed by Calico Life Sciences Llc filed Critical Calico Life Sciences Llc
Publication of MX2021013197A publication Critical patent/MX2021013197A/es

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    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/44—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing eight carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Biomedical Technology (AREA)
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  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se proporcionan en la presente compuestos, composiciones y métodos útiles para modular la respuesta integrada al estrés (ISR) y para tratar enfermedades, trastornos y afecciones relacionadas. (Ver Fórmula I).
MX2021013197A 2019-04-30 2020-04-30 Cicloalquilos sustituidos como moduladores de la vía integrada del estrés. MX2021013197A (es)

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PCT/US2020/030819 WO2020223538A1 (en) 2019-04-30 2020-04-30 Substituted cycloalkyls as modulators of the integrated stress pathway

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JP2021508336A (ja) 2017-12-13 2021-03-04 プラクシス バイオテック エルエルシー 統合的ストレス応答経路の阻害剤
EP3801522A4 (en) 2018-06-05 2022-06-01 Praxis Biotech LLC INTEGRATED STRESS RESPONSE PATHWAY INHIBITORS
TWI832295B (zh) 2018-10-11 2024-02-11 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
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CR20210592A (es) 2022-04-01
AU2020264485A1 (en) 2021-12-02
CO2021015668A2 (es) 2022-04-08
AR118837A1 (es) 2021-11-03
US20200347043A1 (en) 2020-11-05
DOP2021000222A (es) 2022-03-31
UY38686A (es) 2020-11-30
CA3138182A1 (en) 2020-11-05
EP3962906A1 (en) 2022-03-09
BR112021021703A2 (pt) 2022-04-19
WO2020223538A8 (en) 2021-11-18
TW202106679A (zh) 2021-02-16
KR20220016468A (ko) 2022-02-09
CN114206848A (zh) 2022-03-18
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IL287661A (en) 2021-12-01

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