CO2017012545A2 - Sulfonas tricíclicas como moduladores del receptor huérfano relacionado con retinoide gamma (rorγ) - Google Patents

Sulfonas tricíclicas como moduladores del receptor huérfano relacionado con retinoide gamma (rorγ)

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Publication number
CO2017012545A2
CO2017012545A2 CONC2017/0012545A CO2017012545A CO2017012545A2 CO 2017012545 A2 CO2017012545 A2 CO 2017012545A2 CO 2017012545 A CO2017012545 A CO 2017012545A CO 2017012545 A2 CO2017012545 A2 CO 2017012545A2
Authority
CO
Colombia
Prior art keywords
rorγ
modulators
retinoid
receptor gamma
orphan receptor
Prior art date
Application number
CONC2017/0012545A
Other languages
English (en)
Inventor
Lyndon A M Cornelius
T G Murali Dhar
David Marcoux
Qingjie Liu
Douglas G Batt
Jingwu Duan
Qing Shi
Robert J Cherney
Anurag S Srivastava
Bertrand Myra Beaudoin
Carolyn A Weigelt
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CO2017012545A2 publication Critical patent/CO2017012545A2/es

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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

La presente invención se refiere a moduladores de RORγ de la Fórmula (I), ,I y la Fórmula (II) (II) o estereoisómeros, tautómeros, sales de estos farmacéuticamente aceptable, solvatos o profármacos de aquellos, en donde todos los sustituyentes se definen en la presente. También se proporcionan composiciones farmacéuticas que los comprenden. Tales compuestos y composiciones son útiles en los métodos para modular la actividad de RORγ en una célula y en métodos para tratar a un sujeto que tiene una enfermedad o un trastorno en los que el sujeto se beneficiaría terapéuticamente de la modulación de la actividad de RORγ, por ejemplo, trastornos autoinmunitarios y/o inflamatorios.
CONC2017/0012545A 2015-05-07 2017-12-05 Sulfonas tricíclicas como moduladores del receptor huérfano relacionado con retinoide gamma (rorγ) CO2017012545A2 (es)

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PCT/US2016/031118 WO2016179460A1 (en) 2015-05-07 2016-05-06 Tricyclic sulfones as rorϒ modulators

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MX2017014189A (es) 2018-04-13
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EA033345B1 (ru) 2019-09-30
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US9815859B2 (en) 2017-11-14
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