MA41389A1 - Utilisation de sulfones tricycliques en tant que modulateurs de rory - Google Patents

Utilisation de sulfones tricycliques en tant que modulateurs de rory

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Publication number
MA41389A1
MA41389A1 MA41389A MA41389A MA41389A1 MA 41389 A1 MA41389 A1 MA 41389A1 MA 41389 A MA41389 A MA 41389A MA 41389 A MA41389 A MA 41389A MA 41389 A1 MA41389 A1 MA 41389A1
Authority
MA
Morocco
Prior art keywords
modulators
rory
patient
formula
methods
Prior art date
Application number
MA41389A
Other languages
English (en)
Inventor
Jingwu Duan
T G Murali Dhar
David Marcoux
Qing Shi
Douglas G Batt
Qingjie Liu
Robert J Cherney
Lyndon A M Cornelius
Anurag S Srivastava
Bertrand Myra Beaudoin
Carolyn A Weigelt
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MA41389A1 publication Critical patent/MA41389A1/fr

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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
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    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08—Bridged systems

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Abstract

La présente invention concerne des modulateurs de ror? De formule (i) et de formule (ii) ou des stéréoisomères, des tautomères, ainsi que des sels, des solvates ou des promédicaments pharmaceutiquement acceptables correspondants, tous les substituants étant tels que définis dans la description. La présente invention concerne en outre des compositions pharmaceutiques les comprenant. Ces composés et ces compositions sont utiles dans des procédés de modulation de l'activité ror? Dans une cellule, et dans des procédés destinés à traiter un patient atteint d'une maladie ou d'un trouble, où ledit patient peut tirer un avantage thérapeutique de la modulation de l'activité ror?, par exemple, dans le cas de troubles auto-immuns et/ou inflammatoires.
MA41389A 2015-05-07 2016-05-06 Utilisation de sulfones tricycliques en tant que modulateurs de rory MA41389A1 (fr)

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PCT/US2016/031118 WO2016179460A1 (fr) 2015-05-07 2016-05-06 Utilisation de sulfones tricycliques en tant que modulateurs de rorγ

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AU2016258087B2 (en) * 2015-05-07 2020-01-02 Bristol-Myers Squibb Company Tricyclic sulfones as RORϒ modulators
SG10201609616TA (en) * 2016-09-06 2018-04-27 Apple Inc Electronic device with cooling fan
EP3523279A1 (fr) * 2016-10-10 2019-08-14 Bristol-Myers Squibb Company Sulfones tricycliques en tant que modulateurs de ror gamma
EP3526218B1 (fr) 2016-10-13 2021-04-21 Bristol-Myers Squibb Company Sulfones hétérocycliques comme modulateurs de ror gamma
DE102017010487A1 (de) * 2016-12-02 2018-06-07 Merck Patent Gmbh Monofluorierte cyclohexane
US10633339B2 (en) 2018-05-17 2020-04-28 Bristol-Myers Squibb Company Tricyclic sulfone compound as a ROR gamma modulator
KR20210032936A (ko) 2018-06-15 2021-03-25 리아타 파마슈티컬즈, 아이엔씨. Il-17 및 ror감마의 저해를 위한 피라졸 및 이미다졸 화합물
EP3853234A1 (fr) 2018-09-18 2021-07-28 Nikang Therapeutics, Inc. Dérivés d'anneaux tricycliques fusionnés utilisés en tant qu'inhibiteurs de la phosphatase src à homologie-2
US20230295087A1 (en) * 2019-05-13 2023-09-21 Bristol-Myers Squibb Company AGONISTS OF ROR GAMMAt
WO2021150803A1 (fr) * 2020-01-24 2021-07-29 Bristol-Myers Squibb Company SULFONES TRICYCLIQUES EN TANT QUE MODULATEURS DE RORγ
US11332442B2 (en) 2020-08-12 2022-05-17 Bristol-Myers Squibb Company Synthetic process
WO2023232870A1 (fr) 2022-05-31 2023-12-07 Immunic Ag Modulateurs de rorg/rorgt pour le traitement d'infections virales de type covid-19

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AR104555A1 (es) 2017-07-26
AU2016258087B2 (en) 2020-01-02
CN107709295A (zh) 2018-02-16
TW201706244A (zh) 2017-02-16
IL255419A0 (en) 2017-12-31
US20180002358A1 (en) 2018-01-04
CA2987759A1 (fr) 2016-11-10
AU2016258087A1 (en) 2018-01-04
ES2887087T3 (es) 2021-12-21
CL2017002799A1 (es) 2018-05-11
CO2017012545A2 (es) 2018-05-10
US10711020B2 (en) 2020-07-14
JP2018515494A (ja) 2018-06-14
BR112017023780A2 (pt) 2018-07-31
CN107709295B (zh) 2021-05-04
EP3292101B1 (fr) 2021-07-28
KR20180002811A (ko) 2018-01-08
US10273259B2 (en) 2019-04-30
KR102114536B1 (ko) 2020-05-22
PH12017502012A1 (en) 2018-04-02
US20190241588A1 (en) 2019-08-08
MA42049A (fr) 2021-03-17
PE20180119A1 (es) 2018-01-18
EA201792258A1 (ru) 2018-04-30
EA033345B1 (ru) 2019-09-30
MX2017014189A (es) 2018-04-13
TN2017000464A1 (en) 2019-04-12
JP6553746B2 (ja) 2019-07-31
UY36673A (es) 2016-11-30
WO2016179460A1 (fr) 2016-11-10
US9815859B2 (en) 2017-11-14
MY190748A (en) 2022-05-12
EP3292101A1 (fr) 2018-03-14
US20160326195A1 (en) 2016-11-10

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