BR112017023780A2 - sulfonas tricíclicas como moduladores de rorgama - Google Patents
sulfonas tricíclicas como moduladores de rorgamaInfo
- Publication number
- BR112017023780A2 BR112017023780A2 BR112017023780-6A BR112017023780A BR112017023780A2 BR 112017023780 A2 BR112017023780 A2 BR 112017023780A2 BR 112017023780 A BR112017023780 A BR 112017023780A BR 112017023780 A2 BR112017023780 A2 BR 112017023780A2
- Authority
- BR
- Brazil
- Prior art keywords
- rorgama
- modulators
- formula
- methods
- activity
- Prior art date
Links
- 150000003457 sulfones Chemical class 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
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- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- C07D209/04—Indoles; Hydrogenated indoles
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/08—Bridged systems
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Abstract
a presente invenção refere-se a moduladores de rorgama da fórmula (i), , i e fórmula (ii) (ii) ou estereoisômeros, tautômeros, sais farmaceuticamente aceitáveis, solvatos ou profármacos dos mesmos, onde todos os subs-tituintes são definidos aqui. são também providas composições farma-cêuticas compreendendo os mesmos. tais compostos e composições são úteis em métodos para modulação de atividade de rorgama em uma célula e métodos para tratamento de um indivíduo sofrendo de uma doença ou distúrbio onde o indivíduo se beneficiaria terapeuticamente de modulação de atividade de rorgama, por exemplo, distúrbios autoimunes e/ou inflamatórios.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562158178P | 2015-05-07 | 2015-05-07 | |
US62/158,178 | 2015-05-07 | ||
PCT/US2016/031118 WO2016179460A1 (en) | 2015-05-07 | 2016-05-06 | Tricyclic sulfones as rorϒ modulators |
Publications (1)
Publication Number | Publication Date |
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BR112017023780A2 true BR112017023780A2 (pt) | 2018-07-31 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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BR112017023780-6A BR112017023780A2 (pt) | 2015-05-07 | 2016-05-06 | sulfonas tricíclicas como moduladores de rorgama |
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US (3) | US9815859B2 (pt) |
EP (1) | EP3292101B1 (pt) |
JP (1) | JP6553746B2 (pt) |
KR (1) | KR102114536B1 (pt) |
CN (1) | CN107709295B (pt) |
AR (1) | AR104555A1 (pt) |
AU (1) | AU2016258087B2 (pt) |
BR (1) | BR112017023780A2 (pt) |
CA (1) | CA2987759A1 (pt) |
CL (1) | CL2017002799A1 (pt) |
CO (1) | CO2017012545A2 (pt) |
EA (1) | EA033345B1 (pt) |
ES (1) | ES2887087T3 (pt) |
HK (1) | HK1249500A1 (pt) |
IL (1) | IL255419A0 (pt) |
MA (2) | MA41389A1 (pt) |
MX (1) | MX2017014189A (pt) |
MY (1) | MY190748A (pt) |
PE (1) | PE20180119A1 (pt) |
PH (1) | PH12017502012A1 (pt) |
TN (1) | TN2017000464A1 (pt) |
TW (1) | TW201706244A (pt) |
UY (1) | UY36673A (pt) |
WO (1) | WO2016179460A1 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR104555A1 (es) * | 2015-05-07 | 2017-07-26 | Bristol Myers Squibb Co | SULFONAS TRICÍCLICAS COMO MODULARES DE RORg |
SG10201609616TA (en) * | 2016-09-06 | 2018-04-27 | Apple Inc | Electronic device with cooling fan |
KR20190057388A (ko) * | 2016-10-10 | 2019-05-28 | 브리스톨-마이어스 스큅 컴퍼니 | Ror 감마 조정제로서의 트리시클릭 술폰 |
EP3526218B1 (en) | 2016-10-13 | 2021-04-21 | Bristol-Myers Squibb Company | Heterocyclic sulfones as ror gamma modulators |
DE102017010487A1 (de) * | 2016-12-02 | 2018-06-07 | Merck Patent Gmbh | Monofluorierte cyclohexane |
KR20210009357A (ko) * | 2018-05-17 | 2021-01-26 | 브리스톨-마이어스 스큅 컴퍼니 | Ror 감마 조정제로서의 트리시클릭 술폰 화합물 |
EP3807265A1 (en) | 2018-06-15 | 2021-04-21 | Reata Pharmaceuticals, Inc. | Pyrazole and imidazole compounds for inhibition of il-17 and rorgamma |
AU2019344899A1 (en) | 2018-09-18 | 2021-04-15 | Nikang Therapeutics, Inc. | Fused tricyclic ring derivatives as Src homology-2 phosphatase inhibitors |
WO2020231766A1 (en) * | 2019-05-13 | 2020-11-19 | Bristol-Myers Squibb Company | AGONISTS OF ROR GAMMAt |
EP4093732A1 (en) * | 2020-01-24 | 2022-11-30 | Bristol-Myers Squibb Company | Tricyclic sulfones as ror gamma modulators |
US11332442B2 (en) | 2020-08-12 | 2022-05-17 | Bristol-Myers Squibb Company | Synthetic process |
WO2023232870A1 (en) | 2022-05-31 | 2023-12-07 | Immunic Ag | Rorg/rorgt modulators for the treatment of virus infections like covid-19 |
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BRPI0509803A (pt) | 2004-04-13 | 2007-09-18 | Incyte Corp | derivados de piperazinilpiperidina como antagonistas de receptor de quimiocina |
US20070155738A1 (en) | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
CN102702044A (zh) * | 2006-01-20 | 2012-10-03 | 先灵公司 | 作为γ分泌酶抑制剂的碳环和杂环芳基砜化合物 |
KR20100044840A (ko) | 2007-07-17 | 2010-04-30 | 쉐링 코포레이션 | 벤젠설포닐-크로만, 티오크로만, 테트라하이드로나프탈렌 및 관련 감마 세크레타제 억제제 |
RU2014149149A (ru) | 2012-05-08 | 2016-07-10 | Мерк Шарп И Доум Корп. | БИЦИКЛИЧЕСКИЕ СУЛЬФОНОВЫЕ СОЕДИНЕНИЯ ДЛЯ ИНГИБИРОВАНИЯ RORгамма АКТИВНОСТИ И ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ |
EP2669286A1 (en) | 2012-05-31 | 2013-12-04 | Ares Trading S.A. | Spiro tetrahydro-benzothiophen derivatives useful for the treatment of neurodegenerative diseases |
WO2014062938A1 (en) | 2012-10-19 | 2014-04-24 | Bristol-Myers Squibb Company | Rory modulators |
MX2015011618A (es) | 2013-03-08 | 2015-12-17 | Amgen Inc | Compuestos de 1,3-oxazin-2-amina fusionados con ciclopropilo perfluorado como inhibidores de beta-secretasa y metodos de uso. |
JP6407285B2 (ja) | 2013-09-09 | 2018-10-17 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | RORγ調節因子 |
EP3046906B1 (en) | 2013-09-20 | 2017-08-16 | Bristol-Myers Squibb Company | Ror gamma modulators |
EP3092215B1 (en) | 2014-01-06 | 2018-10-17 | Bristol-Myers Squibb Company | Cyclohexyl sulfone ror gamma modulators |
WO2015103508A1 (en) | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | CARBOCYCLIC SULFONE RORγ MODULATORS |
ES2669208T3 (es) | 2014-01-06 | 2018-05-24 | Bristol-Myers Squibb Company | Derivados de pirrolidinilsulfona y su uso como moduladores de ROR gamma |
JP6476205B2 (ja) | 2014-01-06 | 2019-02-27 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | RORγ修飾因子としてのヘテロ環式スルホン |
AR104555A1 (es) * | 2015-05-07 | 2017-07-26 | Bristol Myers Squibb Co | SULFONAS TRICÍCLICAS COMO MODULARES DE RORg |
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2016
- 2016-05-06 AR ARP160101311A patent/AR104555A1/es unknown
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- 2016-05-06 MA MA41389A patent/MA41389A1/fr unknown
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- 2016-05-06 AU AU2016258087A patent/AU2016258087B2/en not_active Ceased
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- 2016-05-06 KR KR1020177035023A patent/KR102114536B1/ko active IP Right Grant
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- 2016-05-06 WO PCT/US2016/031118 patent/WO2016179460A1/en active Application Filing
- 2016-05-06 MA MA042049A patent/MA42049A/fr unknown
- 2016-05-06 EA EA201792258A patent/EA033345B1/ru not_active IP Right Cessation
- 2016-05-06 BR BR112017023780-6A patent/BR112017023780A2/pt not_active Application Discontinuation
- 2016-05-06 TN TNP/2017/000464A patent/TN2017000464A1/en unknown
- 2016-05-06 CN CN201680034253.8A patent/CN107709295B/zh active Active
- 2016-05-06 CA CA2987759A patent/CA2987759A1/en not_active Abandoned
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2017
- 2017-09-12 US US15/701,818 patent/US10273259B2/en active Active
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- 2017-12-05 CO CONC2017/0012545A patent/CO2017012545A2/es unknown
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2018
- 2018-06-04 HK HK18107277.9A patent/HK1249500A1/zh unknown
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2019
- 2019-03-07 US US16/295,378 patent/US10711020B2/en active Active
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