MX369347B - Derivados de pirrolidinilsulfona y su uso como moduladores del receptor huerfano relacionado con retinoide gamma (ror gamma). - Google Patents
Derivados de pirrolidinilsulfona y su uso como moduladores del receptor huerfano relacionado con retinoide gamma (ror gamma).Info
- Publication number
- MX369347B MX369347B MX2016008845A MX2016008845A MX369347B MX 369347 B MX369347 B MX 369347B MX 2016008845 A MX2016008845 A MX 2016008845A MX 2016008845 A MX2016008845 A MX 2016008845A MX 369347 B MX369347 B MX 369347B
- Authority
- MX
- Mexico
- Prior art keywords
- ror
- pyrrolidinyl
- sulfone derivatives
- ror gamma
- gamma modulators
- Prior art date
Links
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Abstract
Se describen moduladores de ROR? de la fórmula (I), (ver Fórmula) o sus estereoisómeros, tautómeros, sales, solvatos o profármacos farmacéuticamente aceptables, en donde todos los sustituyentes se definen en la presente. También se proporcionan composiciones farmacéuticas que los comprenden. Tales compuestos y composiciones son de utilidad en métodos para modular la actividad de ROR? en una célula y métodos para el tratamiento de un sujeto que padece de una enfermedad o trastorno en los que el sujeto se beneficiaría terapéuticamente de la modulación de la actividad de ROR?, por ejemplo, trastornos autoinmunes y/o inflamatorios.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461923896P | 2014-01-06 | 2014-01-06 | |
PCT/US2015/010089 WO2015103509A1 (en) | 2014-01-06 | 2015-01-05 | Pyrrolidinyl sulfone derivatives and their use as ror gamma modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2016008845A MX2016008845A (es) | 2016-09-07 |
MX369347B true MX369347B (es) | 2019-11-06 |
Family
ID=52359012
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016008845A MX369347B (es) | 2014-01-06 | 2015-01-05 | Derivados de pirrolidinilsulfona y su uso como moduladores del receptor huerfano relacionado con retinoide gamma (ror gamma). |
Country Status (11)
Country | Link |
---|---|
US (2) | US20160326108A1 (es) |
EP (1) | EP3092229B1 (es) |
JP (1) | JP6530764B2 (es) |
CN (1) | CN106061971B (es) |
AR (1) | AR099029A1 (es) |
CA (1) | CA2936116A1 (es) |
EA (1) | EA030849B1 (es) |
ES (1) | ES2669208T3 (es) |
MX (1) | MX369347B (es) |
TW (1) | TW201609634A (es) |
WO (1) | WO2015103509A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3044219A1 (en) | 2013-09-09 | 2016-07-20 | Bristol-Myers Squibb Company | Rorgamma modulators |
EP3046906B1 (en) | 2013-09-20 | 2017-08-16 | Bristol-Myers Squibb Company | Ror gamma modulators |
US9771320B2 (en) | 2014-01-06 | 2017-09-26 | Bristol-Myers Squibb Company | Carbocyclic sulfone RORγ modulators |
ES2704460T3 (es) * | 2014-01-06 | 2019-03-18 | Bristol Myers Squibb Co | Moduladores de ROR gamma de ciclohexilsulfona |
EP3092221B1 (en) | 2014-01-06 | 2018-10-17 | Bristol-Myers Squibb Company | Heterocyclic sulfones as ror-gamma modulators |
PL3212642T3 (pl) | 2014-10-30 | 2020-04-30 | Janssen Pharmaceutica Nv | Tiazole podstawione amidami jako modulatory rorgammat |
JOP20200117A1 (ar) | 2014-10-30 | 2017-06-16 | Janssen Pharmaceutica Nv | كحولات ثلاثي فلوروميثيل كمُعدلات للمستقبل النووي جاما تي المرتبط بحمض الريتيونَويك ROR?t |
CA2965515A1 (en) | 2014-10-30 | 2016-05-06 | Janssen Pharmaceutica Nv | Thiazoles as modulators of ror.gamma.t |
CA2987759A1 (en) | 2015-05-07 | 2016-11-10 | Bristol-Myers Squibb Company | Tricyclic sulfones as ror.gamma. modulators |
US10610520B2 (en) | 2016-03-31 | 2020-04-07 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
TW201803869A (zh) | 2016-04-27 | 2018-02-01 | 健生藥品公司 | 作為RORγT調節劑之6-胺基吡啶-3-基噻唑 |
WO2018071314A1 (en) * | 2016-10-10 | 2018-04-19 | Bristol-Myers Squibb Company | Tricyclic sulfones as ror gamma modulators |
CN110049985B (zh) * | 2016-10-13 | 2022-05-31 | 百时美施贵宝公司 | 作为RORγ调节剂的杂环砜类 |
CA3042877A1 (en) * | 2016-11-09 | 2018-05-17 | Bristol-Myers Squibb Company | Tricyclic sulfones as ror gamma modulators |
CN110167930A (zh) * | 2016-11-10 | 2019-08-23 | 百时美施贵宝公司 | RORγ调节剂 |
WO2019243999A1 (en) | 2018-06-18 | 2019-12-26 | Janssen Pharmaceutica Nv | Phenyl substituted pyrazoles as modulators of roryt |
WO2019244000A1 (en) | 2018-06-18 | 2019-12-26 | Janssen Pharmaceutica Nv | Phenyl and pyridinyl substituted imidazoles as modulators of roryt |
CN112292183A (zh) | 2018-06-18 | 2021-01-29 | 詹森药业有限公司 | 作为RORγt的调节剂的6-氨基吡啶-3-基吡唑 |
EP3807261B1 (en) | 2018-06-18 | 2022-07-13 | Janssen Pharmaceutica NV | Pyridinyl pyrazoles as modulators of roryt |
EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | PYRROLE AND PYRAZOLE COMPOUNDS AND METHODS OF USE THERE |
WO2020231713A1 (en) * | 2019-05-13 | 2020-11-19 | Bristol-Myers Squibb Company | AGONISTS OF ROR GAMMAt |
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GB0108591D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
AU2012275499A1 (en) | 2011-06-27 | 2013-12-19 | Kyorin Pharmaceutical Co., Ltd. | Bridged bicyclic compounds for the treatment of bacterial infections |
US20130190356A1 (en) * | 2011-12-22 | 2013-07-25 | Genentech, Inc. | Benzyl sulfonamide derivatives as rorc modulators |
KR20150013500A (ko) * | 2012-05-08 | 2015-02-05 | 머크 샤프 앤드 돔 코포레이션 | Ror감마 활성의 억제를 위한 비시클릭 술폰 화합물 및 질환의 치료 |
AR091279A1 (es) | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
WO2014028669A1 (en) * | 2012-08-15 | 2014-02-20 | Biogen Idec Ma Inc. | Novel compounds for modulation of ror-gamma activity |
US9771320B2 (en) | 2014-01-06 | 2017-09-26 | Bristol-Myers Squibb Company | Carbocyclic sulfone RORγ modulators |
EP3092221B1 (en) | 2014-01-06 | 2018-10-17 | Bristol-Myers Squibb Company | Heterocyclic sulfones as ror-gamma modulators |
ES2704460T3 (es) | 2014-01-06 | 2019-03-18 | Bristol Myers Squibb Co | Moduladores de ROR gamma de ciclohexilsulfona |
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- 2015-01-05 JP JP2016562465A patent/JP6530764B2/ja not_active Expired - Fee Related
- 2015-01-05 US US15/109,719 patent/US20160326108A1/en not_active Abandoned
- 2015-01-05 EP EP15700613.1A patent/EP3092229B1/en not_active Not-in-force
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WO2015103509A1 (en) | 2015-07-09 |
AR099029A1 (es) | 2016-06-22 |
CA2936116A1 (en) | 2015-07-09 |
CN106061971A (zh) | 2016-10-26 |
MX2016008845A (es) | 2016-09-07 |
EP3092229B1 (en) | 2018-03-28 |
EA201691368A1 (ru) | 2016-10-31 |
CN106061971B (zh) | 2019-03-12 |
US9458171B2 (en) | 2016-10-04 |
JP6530764B2 (ja) | 2019-06-12 |
TW201609634A (zh) | 2016-03-16 |
EP3092229A1 (en) | 2016-11-16 |
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