EA033345B1 - ТРИЦИКЛИЧЕСКИЕ СУЛЬФОНЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ RORγ - Google Patents

ТРИЦИКЛИЧЕСКИЕ СУЛЬФОНЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ RORγ

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Publication number
EA033345B1
EA033345B1 EA201792258A EA201792258A EA033345B1 EA 033345 B1 EA033345 B1 EA 033345B1 EA 201792258 A EA201792258 A EA 201792258A EA 201792258 A EA201792258 A EA 201792258A EA 033345 B1 EA033345 B1 EA 033345B1
Authority
EA
Eurasian Patent Office
Prior art keywords
rorγ
rorγ modulators
modulators
sulfones
tricyclic
Prior art date
Application number
EA201792258A
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English (en)
Other versions
EA201792258A1 (ru
Inventor
Джингву Дуан
Т.Г. Мурали Дхар
Дэйвид Марку
Цин Ши
Дуглас Г. Батт
Цинцзе Лю
Роберт Дж. Черни
Линдон А.М. Корнелиус
Анураг С. Сривастава
Мира Бодуэн Бертран
Кэролин А. Уэйгелт
Original Assignee
Бристол-Майерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Майерс Сквибб Компани filed Critical Бристол-Майерс Сквибб Компани
Publication of EA201792258A1 publication Critical patent/EA201792258A1/ru
Publication of EA033345B1 publication Critical patent/EA033345B1/ru

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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

В изобретении раскрыты модуляторы RORγ формулыих стереоизомеры и фармацевтически приемлемые соли, где все заместители указаны в формуле изобретения. Также представлены содержащие их фармацевтические композиции. Такие соединения и композиции могут применяться для модуляции активности RORγ в клетке и в способах лечения субъекта, страдающего заболеванием или расстройством, связанным с активностью RORγ, например аутоиммунным и/или воспалительным расстройством.
EA201792258A 2015-05-07 2016-05-06 ТРИЦИКЛИЧЕСКИЕ СУЛЬФОНЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ RORγ EA033345B1 (ru)

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