MA43979B1 - Dérivés de 1h-indazole-3-carboxamide et composés similaires en tant qu'inhibiteurs du facteur d pour le traitement de maladies characterisés par une activité aberrante du système complémentaire, comme p.E. Troubles immunologiques - Google Patents

Dérivés de 1h-indazole-3-carboxamide et composés similaires en tant qu'inhibiteurs du facteur d pour le traitement de maladies characterisés par une activité aberrante du système complémentaire, comme p.E. Troubles immunologiques

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Publication number
MA43979B1
MA43979B1 MA43979A MA43979A MA43979B1 MA 43979 B1 MA43979 B1 MA 43979B1 MA 43979 A MA43979 A MA 43979A MA 43979 A MA43979 A MA 43979A MA 43979 B1 MA43979 B1 MA 43979B1
Authority
MA
Morocco
Prior art keywords
treatment
indazole
aberrant activity
similar compounds
diseases characterized
Prior art date
Application number
MA43979A
Other languages
English (en)
Inventor
Pravin Kotian
Yarlagadda Babu
Minwan Wu
Venkat Chintareddy
Weihe Zhang
Lakshminarayana Vogeti
Krishnan Raman
Original Assignee
Biocryst Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocryst Pharm Inc filed Critical Biocryst Pharm Inc
Publication of MA43979B1 publication Critical patent/MA43979B1/fr

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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Abstract

L'invention concerne des composés de formule (i), et leurs sels pharmaceutiquement acceptables. Les composés sont des inhibiteurs du système du complément. L'invention concerne également des compositions pharmaceutiques comprenant un composé de formule (i), et des méthodes impliquant l'utilisation des composés et des compositions dans le traitement et la prévention de maladies et d'états pathologiques caractérisés par une activité aberrante du système du complément.
MA43979A 2016-02-01 2017-02-01 Dérivés de 1h-indazole-3-carboxamide et composés similaires en tant qu'inhibiteurs du facteur d pour le traitement de maladies characterisés par une activité aberrante du système complémentaire, comme p.E. Troubles immunologiques MA43979B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662289653P 2016-02-01 2016-02-01
PCT/US2017/015953 WO2017136395A1 (fr) 2016-02-01 2017-02-01 Composés benzopyrazole et analogues de ceux-ci

Publications (1)

Publication Number Publication Date
MA43979B1 true MA43979B1 (fr) 2021-06-30

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Application Number Title Priority Date Filing Date
MA43979A MA43979B1 (fr) 2016-02-01 2017-02-01 Dérivés de 1h-indazole-3-carboxamide et composés similaires en tant qu'inhibiteurs du facteur d pour le traitement de maladies characterisés par une activité aberrante du système complémentaire, comme p.E. Troubles immunologiques

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US (3) US10849883B2 (fr)
EP (2) EP3411411B3 (fr)
JP (2) JP6924766B2 (fr)
KR (1) KR20180117624A (fr)
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HU (1) HUE055258T2 (fr)
IL (2) IL290154B2 (fr)
LT (1) LT3411411T (fr)
MA (1) MA43979B1 (fr)
MD (1) MD3411411T2 (fr)
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MY (1) MY201629A (fr)
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