MD3411411T2 - Derivați de 1H-indazol-3-carboxamidă și compuși înrudiți în calitate de inhibitori ai factorului D pentru tratamentul bolilor caracterizate prin activitate aberantă a sistemului complementului, cum ar fi, de exemplu, tulburări imunologice - Google Patents

Derivați de 1H-indazol-3-carboxamidă și compuși înrudiți în calitate de inhibitori ai factorului D pentru tratamentul bolilor caracterizate prin activitate aberantă a sistemului complementului, cum ar fi, de exemplu, tulburări imunologice

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Publication number
MD3411411T2
MD3411411T2 MDE20181197T MDE20181197T MD3411411T2 MD 3411411 T2 MD3411411 T2 MD 3411411T2 MD E20181197 T MDE20181197 T MD E20181197T MD E20181197 T MDE20181197 T MD E20181197T MD 3411411 T2 MD3411411 T2 MD 3411411T2
Authority
MD
Moldova
Prior art keywords
inhibitors
complement system
indazole
factor
related compounds
Prior art date
Application number
MDE20181197T
Other languages
English (en)
Inventor
Pravin L Kotian
Yarlagadda S Babu
Weihe Zhang
Lakshminarayana Vogeti
Minwan Wu
Venkat R Chintareddy
Krishnan Raman
Original Assignee
Biocryst Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocryst Pharm Inc filed Critical Biocryst Pharm Inc
Publication of MD3411411T2 publication Critical patent/MD3411411T2/ro

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Se dezvăluie compuşi conform formulei I şi săruri acceptabile farmaceutic ale acestora. Compuşii sunt inhibitori ai sistemului complement. De asemenea, se furnizează compoziţii farmaceutice care cuprind un compus conform formulei I şi metode prin care se utilizează compuşii şi compoziţiile în tratamentul şi prevenţia bolilor şi afecţiunilor caracterizate prin activitate aberantă a sistemului complement.
MDE20181197T 2016-02-01 2017-02-01 Derivați de 1H-indazol-3-carboxamidă și compuși înrudiți în calitate de inhibitori ai factorului D pentru tratamentul bolilor caracterizate prin activitate aberantă a sistemului complementului, cum ar fi, de exemplu, tulburări imunologice MD3411411T2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662289653P 2016-02-01 2016-02-01
PCT/US2017/015953 WO2017136395A1 (en) 2016-02-01 2017-02-01 Benzopyrazole compounds and analogues thereof

Publications (1)

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MD3411411T2 true MD3411411T2 (ro) 2021-11-30

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MDE20181197T MD3411411T2 (ro) 2016-02-01 2017-02-01 Derivați de 1H-indazol-3-carboxamidă și compuși înrudiți în calitate de inhibitori ai factorului D pentru tratamentul bolilor caracterizate prin activitate aberantă a sistemului complementului, cum ar fi, de exemplu, tulburări imunologice

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US (3) US10849883B2 (ro)
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JP (2) JP6924766B2 (ro)
KR (1) KR20180117624A (ro)
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