TN2013000393A1 - Derives de la pyrazolospirocetone pour une utilisation comme inhibiteurs de l'acetyl-coa carboxylase - Google Patents

Derives de la pyrazolospirocetone pour une utilisation comme inhibiteurs de l'acetyl-coa carboxylase

Info

Publication number
TN2013000393A1
TN2013000393A1 TNP2013000393A TN2013000393A TN2013000393A1 TN 2013000393 A1 TN2013000393 A1 TN 2013000393A1 TN P2013000393 A TNP2013000393 A TN P2013000393A TN 2013000393 A TN2013000393 A TN 2013000393A TN 2013000393 A1 TN2013000393 A1 TN 2013000393A1
Authority
TN
Tunisia
Prior art keywords
acetyl
coa carboxylase
pyrazolospirocetone
inhibitors
derivatives
Prior art date
Application number
TNP2013000393A
Other languages
English (en)
Inventor
David Andrew Griffith
Robert Lee Dow
James Alfred Southers Jr
David James Edmonds
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TN2013000393A1 publication Critical patent/TN2013000393A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Photographic Processing Devices Using Wet Methods (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention propose un composé de formule (I) ou un de ses sels pharmaceutiquement acceptables associés; dans laquelle G représente (II) ou (III); R1, R2 et R3 sont tels que décrite ici; leurs compositions pharmaceutiques associées; et leur utilisation associée dans le traitement de maladies, états ou troubles modulés par l'inhibition d'une (d') enzyme (s) acétyl-CoA carboxylase chez un animal.
TNP2013000393A 2011-04-22 2013-09-27 Derives de la pyrazolospirocetone pour une utilisation comme inhibiteurs de l'acetyl-coa carboxylase TN2013000393A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161478240P 2011-04-22 2011-04-22
PCT/IB2012/051732 WO2012143813A1 (fr) 2011-04-22 2012-04-09 Dérivés de pyrazolospirocétone destinés à être utilisés comme inhibiteurs d'acétyl-coa carboxylase

Publications (1)

Publication Number Publication Date
TN2013000393A1 true TN2013000393A1 (fr) 2015-01-20

Family

ID=46025823

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2013000393A TN2013000393A1 (fr) 2011-04-22 2013-09-27 Derives de la pyrazolospirocetone pour une utilisation comme inhibiteurs de l'acetyl-coa carboxylase

Country Status (41)

Country Link
US (4) US8802688B2 (fr)
EP (1) EP2699576B1 (fr)
JP (1) JP5657174B2 (fr)
KR (1) KR101567659B1 (fr)
CN (2) CN106117205B (fr)
AP (1) AP3499A (fr)
AR (1) AR086198A1 (fr)
AU (1) AU2012245996B2 (fr)
CA (1) CA2831380C (fr)
CL (1) CL2013002794A1 (fr)
CO (1) CO6801757A2 (fr)
CR (1) CR20130464A (fr)
CU (1) CU24164B1 (fr)
CY (1) CY1117122T1 (fr)
DK (1) DK2699576T3 (fr)
DO (1) DOP2013000243A (fr)
EA (1) EA022375B1 (fr)
EC (1) ECSP13013038A (fr)
ES (1) ES2561452T3 (fr)
GE (1) GEP20166474B (fr)
GT (1) GT201300258A (fr)
HR (1) HRP20151397T1 (fr)
HU (1) HUE028602T2 (fr)
IL (1) IL228949A (fr)
MA (1) MA35061B1 (fr)
ME (1) ME02312B (fr)
MX (1) MX348860B (fr)
MY (1) MY162167A (fr)
NI (1) NI201300111A (fr)
NZ (1) NZ616156A (fr)
PE (1) PE20141187A1 (fr)
PL (1) PL2699576T3 (fr)
PT (1) PT2699576E (fr)
RS (1) RS54526B1 (fr)
SG (1) SG194142A1 (fr)
SI (1) SI2699576T1 (fr)
TN (1) TN2013000393A1 (fr)
TW (1) TWI464171B (fr)
UA (1) UA107753C2 (fr)
UY (1) UY34027A (fr)
WO (1) WO2012143813A1 (fr)

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Also Published As

Publication number Publication date
CN106117205A (zh) 2016-11-16
GEP20166474B (en) 2016-05-10
EP2699576A1 (fr) 2014-02-26
CU20130126A7 (es) 2014-01-29
US8802688B2 (en) 2014-08-12
JP2014515755A (ja) 2014-07-03
IL228949A (en) 2016-11-30
ECSP13013038A (es) 2014-01-31
AU2012245996B2 (en) 2016-09-01
UA107753C2 (xx) 2015-02-10
US20120270893A1 (en) 2012-10-25
US20150112068A1 (en) 2015-04-23
CY1117122T1 (el) 2017-04-05
CR20130464A (es) 2013-10-16
AP3499A (en) 2015-12-31
MY162167A (en) 2017-05-31
CU24164B1 (es) 2016-03-31
NZ616156A (en) 2014-08-29
AR086198A1 (es) 2013-11-27
CN106117205B (zh) 2018-09-21
CN103492388A (zh) 2014-01-01
PE20141187A1 (es) 2014-09-18
EA022375B1 (ru) 2015-12-30
US20150336958A1 (en) 2015-11-26
ES2561452T3 (es) 2016-02-26
PT2699576E (pt) 2016-03-09
NI201300111A (es) 2014-02-12
US20140323730A1 (en) 2014-10-30
RS54526B1 (en) 2016-06-30
DOP2013000243A (es) 2013-12-31
GT201300258A (es) 2015-06-02
MX348860B (es) 2017-06-30
TW201305162A (zh) 2013-02-01
IL228949A0 (en) 2013-12-31
SG194142A1 (en) 2013-11-29
AU2012245996A1 (en) 2013-10-03
EA201391288A1 (ru) 2014-04-30
CO6801757A2 (es) 2013-11-29
AP2013007129A0 (en) 2013-09-30
PL2699576T3 (pl) 2016-05-31
EP2699576B1 (fr) 2015-12-09
CA2831380C (fr) 2016-04-05
HRP20151397T1 (hr) 2016-01-15
KR20140015511A (ko) 2014-02-06
CL2013002794A1 (es) 2013-12-27
TWI464171B (zh) 2014-12-11
WO2012143813A1 (fr) 2012-10-26
SI2699576T1 (sl) 2016-02-29
KR101567659B1 (ko) 2015-11-09
ME02312B (me) 2016-06-20
UY34027A (es) 2013-04-05
HUE028602T2 (hu) 2016-12-28
MX2013012313A (es) 2014-01-31
DK2699576T3 (en) 2016-02-15
CA2831380A1 (fr) 2012-10-26
JP5657174B2 (ja) 2015-01-21
MA35061B1 (fr) 2014-04-03

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