AR086198A1 - Inhibidores sustituidos de acetil-coa carboxilasa y composiciones farmaceuticas que los contienen - Google Patents
Inhibidores sustituidos de acetil-coa carboxilasa y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR086198A1 AR086198A1 ARP120101364A ARP120101364A AR086198A1 AR 086198 A1 AR086198 A1 AR 086198A1 AR P120101364 A ARP120101364 A AR P120101364A AR P120101364 A ARP120101364 A AR P120101364A AR 086198 A1 AR086198 A1 AR 086198A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- coa carboxylase
- cycloalkyl
- acetil
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
Uso del mismo en el tratamiento de enfermedades, afecciones o trastornos modulados por la inhibición de una enzima(s) acetil-CoA carboxilasa en un animal.Reivindicación 1: Un compuesto de fórmula (1) o una sal del mismo aceptable desde el punto de vista farmacéutico; donde G es un resto de fórmula (2) ó (3); R1 es un alquilo C1-6 o cicloalquilo C3-7; R2 es indolilo, indazolilo, pirrolopiridinilo, pirazolopiridinilo, quinolinilo o benzoimidazolilo; donde cada grupo R2 es sustituido opcionalmente con uno a dos sustituyentes seleccionados independientemente de un ciano, -L-C(O)NR4R5, -L-NR4R5, alquilo C1-3, alcoxi C1-3 y halo; R3 es hidrógeno o alquilo C1-3; L es una unión directa o -X-alquileno C1-3; X es una unión directa, O ó S; R4 y R5 son cada uno independientemente hidrógeno, alquilo C1-3, cicloalquilo C3-7 o heterociclilo de cuatro a siete miembros donde dicho alquilo C1-3, cicloalquilo C3-7 o heterociclilo de cuatro a siete miembros es sustituido opcionalmente con uno a tres fluoro o alcoxi C1-3.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478240P | 2011-04-22 | 2011-04-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086198A1 true AR086198A1 (es) | 2013-11-27 |
Family
ID=46025823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101364A AR086198A1 (es) | 2011-04-22 | 2012-04-20 | Inhibidores sustituidos de acetil-coa carboxilasa y composiciones farmaceuticas que los contienen |
Country Status (41)
| Country | Link |
|---|---|
| US (4) | US8802688B2 (es) |
| EP (1) | EP2699576B1 (es) |
| JP (1) | JP5657174B2 (es) |
| KR (1) | KR101567659B1 (es) |
| CN (2) | CN106117205B (es) |
| AP (1) | AP3499A (es) |
| AR (1) | AR086198A1 (es) |
| AU (1) | AU2012245996B2 (es) |
| CA (1) | CA2831380C (es) |
| CL (1) | CL2013002794A1 (es) |
| CO (1) | CO6801757A2 (es) |
| CR (1) | CR20130464A (es) |
| CU (1) | CU24164B1 (es) |
| CY (1) | CY1117122T1 (es) |
| DK (1) | DK2699576T3 (es) |
| DO (1) | DOP2013000243A (es) |
| EA (1) | EA022375B1 (es) |
| EC (1) | ECSP13013038A (es) |
| ES (1) | ES2561452T3 (es) |
| GE (1) | GEP20166474B (es) |
| GT (1) | GT201300258A (es) |
| HR (1) | HRP20151397T1 (es) |
| HU (1) | HUE028602T2 (es) |
| IL (1) | IL228949A (es) |
| MA (1) | MA35061B1 (es) |
| ME (1) | ME02312B (es) |
| MX (1) | MX348860B (es) |
| MY (1) | MY162167A (es) |
| NI (1) | NI201300111A (es) |
| NZ (1) | NZ616156A (es) |
| PE (1) | PE20141187A1 (es) |
| PL (1) | PL2699576T3 (es) |
| PT (1) | PT2699576E (es) |
| RS (1) | RS54526B1 (es) |
| SG (1) | SG194142A1 (es) |
| SI (1) | SI2699576T1 (es) |
| TN (1) | TN2013000393A1 (es) |
| TW (1) | TWI464171B (es) |
| UA (1) | UA107753C2 (es) |
| UY (1) | UY34027A (es) |
| WO (1) | WO2012143813A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101478517B1 (ko) * | 2009-11-10 | 2015-01-02 | 화이자 인코포레이티드 | Ｎ1-피라졸로스피로케톤 아세틸-ｃｏａ 카복실라아제 억제제 |
| CN102491974B (zh) * | 2011-12-12 | 2013-08-07 | 南京药石药物研发有限公司 | 1-（2-氟苄基）-1H-吡唑并[3，4-b]吡啶-3-甲脒盐酸盐的合成方法 |
| US9447026B2 (en) | 2013-03-14 | 2016-09-20 | Kalyra Pharmaceuticals, Inc. | Bicyclic analgesic compounds |
| MX2015015417A (es) | 2013-05-10 | 2016-06-21 | Nimbus Apollo Inc | Inhibidores de acetil-coa carboxilasa (acc) y usos de los mismos. |
| JP6434498B2 (ja) | 2013-05-10 | 2018-12-05 | ギリアド アポロ， エルエルシー | Ａｃｃ阻害剤及びその使用 |
| CN105358155A (zh) | 2013-05-10 | 2016-02-24 | 尼普斯阿波罗有限公司 | Acc抑制剂和其用途 |
| AU2014319990A1 (en) * | 2013-09-12 | 2016-02-25 | Pfizer Inc. | Use of acetyl-CoA carboxylase inhibitors for treating acne vulgaris |
| EP3670496A3 (en) | 2013-10-17 | 2020-09-30 | Shionogi&Co., Ltd. | Acc2 inhibitors |
| CN105814013A (zh) * | 2013-12-12 | 2016-07-27 | 卡利拉制药公司 | 双环烷基化合物及合成 |
| KR102401840B1 (ko) * | 2014-03-07 | 2022-05-25 | 리커리엄 아이피 홀딩스, 엘엘씨 | 프로펠란 유도체 및 합성 |
| CA2892342C (en) | 2014-05-22 | 2016-11-01 | Sylvain-Paul Morency | Tool and method for layer depalletizing |
| JP6833677B2 (ja) | 2014-09-17 | 2021-02-24 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | 二環式化合物 |
| CA3010097C (en) * | 2015-12-31 | 2023-08-22 | Institute Of Materia Medica, Chinese Academy Of Medical Sciences | Application of triacetyl-3-hydroxyphenyladenosine in preparation of pharmaceutical drug for preventing or treating non-alcoholic fatty liver disease |
| CN106580986B (zh) * | 2016-11-28 | 2017-09-15 | 王保亮 | 一种治疗少弱精子症的药物组合物 |
| MX2019013557A (es) | 2017-05-15 | 2022-01-27 | Recurium Ip Holdings Llc | Compuestos biciclo[1.1.1]pentilo sustituidos y uso de los mismos para el tratamiento del dolor y fiebre. |
| US11325909B2 (en) | 2017-11-21 | 2022-05-10 | Pfizer Inc. | Crystalline 2-amino-2-(hydroxymethyl)propane-1,3-diol salt of 4-(4-(1-isopropyl-7-OXO-1,4,6,7-tetrahydrospiro[indazole-5,4′-piperidine]-1′-carbonyl)-6-methoxypryridin-2-YL)benzoic acid |
| CN111574530B (zh) * | 2020-04-21 | 2022-07-26 | 徐州医科大学 | 一种acc抑制剂及其医药用途 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2287971T3 (es) | 1997-08-11 | 2007-12-16 | Pfizer Products Inc. | Dispersiones farmaceuticas solidas con biodisponibilidad incrementada. |
| BR0207658A (pt) | 2001-02-28 | 2005-10-25 | Merck & Co Inc | Métodos para o tratamento ou a prevenção de distúrbios, doenças ou condições responsivas à ativação do receptor de melanocortina-4, de obesidade, de diabetes melito, de disfunção sexual masculina ou feminina, e de disfunção erétil em um mamìfero que disto necessita, e, composição farmacêutica |
| CN1642599A (zh) | 2002-02-27 | 2005-07-20 | 辉瑞产品公司 | Acc抑制剂 |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| WO2004092179A1 (ja) | 2003-04-14 | 2004-10-28 | Nippon Soda Co. Ltd. | スピロ誘導体、製造法および抗酸化薬 |
| JP2005119987A (ja) | 2003-10-15 | 2005-05-12 | Ajinomoto Co Inc | アシルスルホンアミド誘導体 |
| RS51106B (sr) | 2004-05-12 | 2010-10-31 | Pfizer Products Inc. | Derivati prolina i njihova upotreba kao inhibitora dipeptidil peptidaze iv |
| US20050267221A1 (en) | 2004-05-14 | 2005-12-01 | Research Development Foundation | Use of curcumin and analogues thereof as inhibitors of ACC2 |
| GEP20094723B (en) | 2004-05-25 | 2009-07-10 | Pfizer Prod Inc | Tetraazabenzo [e] azulene derivatives and analogs thereof |
| PA8660701A1 (es) | 2005-02-04 | 2006-09-22 | Pfizer Prod Inc | Agonistas de pyy y sus usos |
| AU2006270145B2 (en) | 2005-07-19 | 2011-04-14 | Msd K.K. | Spirochromanone derivatives as acetyl coenzyme a carboxylase (ACC) inhibitors |
| EP1911753A1 (en) | 2005-07-29 | 2008-04-16 | Takeda Pharmaceutical Company Limited | Spiro-cyclic compound |
| AU2006316626A1 (en) | 2005-11-18 | 2007-05-31 | Merck Sharp & Dohme Corp. | Spirohydantoin aryl CGRP receptor antagonists |
| US8735595B2 (en) | 2006-02-15 | 2014-05-27 | Abbvie Inc. | Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome |
| CA2648852C (en) | 2006-04-20 | 2012-12-11 | Pfizer Products Inc. | Fused phenyl amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases |
| EP2097420B1 (en) | 2006-11-29 | 2012-04-04 | Pfizer Products Inc. | Spiroketone inhibitors of acetyl-coa carboxylase |
| PE20081559A1 (es) | 2007-01-12 | 2008-11-20 | Merck & Co Inc | DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA |
| EP2123652A1 (en) * | 2007-02-20 | 2009-11-25 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| CN104356136A (zh) | 2007-04-12 | 2015-02-18 | 辉瑞大药厂 | 作为蛋白酶c抑制剂的3-酰氨基-吡咯并[3,4-c]吡唑-5(1h,4h,6h)甲醛衍生物 |
| US20090036425A1 (en) | 2007-08-02 | 2009-02-05 | Pfizer Inc | Substituted bicyclolactam compounds |
| US7981904B2 (en) | 2008-03-20 | 2011-07-19 | Takeda Pharmaceutical Company Limited | Acetyl CoA carboxylase inhibitors |
| EP2297163B1 (en) * | 2008-05-28 | 2015-07-08 | Pfizer Inc. | Pyrazolospiroketone acetyl-CoA carboxylase inhibitors |
| US20110009443A1 (en) | 2008-05-28 | 2011-01-13 | Kevin Daniel Freeman-Cook | Pyrazolospiroketone Acetyl-Coa Carboxylase Inhibitors |
| US8524730B2 (en) * | 2008-07-04 | 2013-09-03 | Msd K.K. | Spirochromanone carboxylic acids |
| AU2009271634A1 (en) | 2008-07-14 | 2010-01-21 | Cropsolution, Inc. | Modulators of acetyl-coenzyme a carboxylase and methods of use thereof |
| WO2010013161A1 (en) | 2008-07-29 | 2010-02-04 | Pfizer Inc. | Fluorinated heteroaryls |
| BRPI0918841B8 (pt) | 2008-08-28 | 2021-05-25 | Pfizer | derivados de dioxa-biciclo[3.2.1]octano-2,3,4-triol, seus cristais, composições farmacêuticas e usos |
| WO2010086820A1 (en) | 2009-02-02 | 2010-08-05 | Pfizer Inc. | 4-amino-5-oxo-7, 8-dihydropyrimido [5,4-f] [1,4] oxazepin-6 (5h) -yl) phenyl derivatives, pharmaceutical compositions and uses thereof |
| BRPI1013246B1 (pt) | 2009-03-11 | 2019-10-01 | Pfizer, Inc. | Derivados de benzofuranila, suas composições farmacêuticas e seus usos |
| CA2754685A1 (en) | 2009-03-11 | 2010-09-16 | Pfizer Inc. | Substituted indazole amides |
| CA2754523A1 (en) | 2009-03-20 | 2010-09-23 | Pfizer Inc. | 3-oxa-7-azabicyclo[3.3.1]nonanes |
| WO2010128414A1 (en) | 2009-05-08 | 2010-11-11 | Pfizer Inc. | Gpr 119 modulators |
| EP2427450A1 (en) | 2009-05-08 | 2012-03-14 | Pfizer Inc. | Gpr 119 modulators |
| WO2010140092A1 (en) | 2009-06-05 | 2010-12-09 | Pfizer Inc. | L- ( piperidin-4-yl) -pyrazole derivatives as gpr 119 modulators |
| WO2011005611A1 (en) | 2009-07-09 | 2011-01-13 | Merck Sharp & Dohme Corp. | Neuromedin u receptor agonists and uses thereof |
| JP2013510191A (ja) * | 2009-11-10 | 2013-03-21 | ファイザー・インク | Ｎ−２ピラゾロスピロケトンアセチル−ＣｏＡカルボキシラーゼ阻害薬 |
| KR101478517B1 (ko) * | 2009-11-10 | 2015-01-02 | 화이자 인코포레이티드 | Ｎ1-피라졸로스피로케톤 아세틸-ｃｏａ 카복실라아제 억제제 |
| PT2621493T (pt) * | 2010-09-30 | 2016-11-14 | Pfizer | Inibidores de n1-pirazolospirocetona acetil-coa carboxilase |
-
2012
- 2012-04-09 PE PE2013002387A patent/PE20141187A1/es not_active Application Discontinuation
- 2012-04-09 CU CU20130126A patent/CU24164B1/es active IP Right Grant
- 2012-04-09 CN CN201610487378.8A patent/CN106117205B/zh not_active Expired - Fee Related
- 2012-04-09 PT PT127183879T patent/PT2699576E/pt unknown
- 2012-04-09 JP JP2014505745A patent/JP5657174B2/ja active Active
- 2012-04-09 EP EP12718387.9A patent/EP2699576B1/en active Active
- 2012-04-09 NZ NZ616156A patent/NZ616156A/en not_active IP Right Cessation
- 2012-04-09 SI SI201230417T patent/SI2699576T1/sl unknown
- 2012-04-09 GE GEAP201213267A patent/GEP20166474B/en unknown
- 2012-04-09 DK DK12718387.9T patent/DK2699576T3/en active
- 2012-04-09 ME MEP-2015-214A patent/ME02312B/me unknown
- 2012-04-09 MA MA36357A patent/MA35061B1/fr unknown
- 2012-04-09 RS RS20160026A patent/RS54526B1/en unknown
- 2012-04-09 ES ES12718387.9T patent/ES2561452T3/es active Active
- 2012-04-09 SG SG2013075148A patent/SG194142A1/en unknown
- 2012-04-09 EA EA201391288A patent/EA022375B1/ru not_active IP Right Cessation
- 2012-04-09 CN CN201280019621.3A patent/CN103492388A/zh active Pending
- 2012-04-09 CA CA2831380A patent/CA2831380C/en active Active
- 2012-04-09 AP AP2013007129A patent/AP3499A/xx active
- 2012-04-09 MY MYPI2013003372A patent/MY162167A/en unknown
- 2012-04-09 HU HUE12718387A patent/HUE028602T2/hu unknown
- 2012-04-09 MX MX2013012313A patent/MX348860B/es active IP Right Grant
- 2012-04-09 PL PL12718387T patent/PL2699576T3/pl unknown
- 2012-04-09 AU AU2012245996A patent/AU2012245996B2/en not_active Ceased
- 2012-04-09 KR KR1020137030875A patent/KR101567659B1/ko active IP Right Grant
- 2012-04-09 WO PCT/IB2012/051732 patent/WO2012143813A1/en active Application Filing
- 2012-04-18 TW TW101113766A patent/TWI464171B/zh not_active IP Right Cessation
- 2012-04-19 UY UY0001034027A patent/UY34027A/es not_active Application Discontinuation
- 2012-04-20 AR ARP120101364A patent/AR086198A1/es unknown
- 2012-04-21 US US13/452,839 patent/US8802688B2/en active Active
- 2012-09-04 UA UAA201311822A patent/UA107753C2/ru unknown
-
2013
- 2013-09-12 CR CR20130464A patent/CR20130464A/es unknown
- 2013-09-27 CL CL2013002794A patent/CL2013002794A1/es unknown
- 2013-09-27 TN TNP2013000393A patent/TN2013000393A1/fr unknown
- 2013-10-17 IL IL228949A patent/IL228949A/en active IP Right Grant
- 2013-10-18 NI NI201300111A patent/NI201300111A/es unknown
- 2013-10-18 GT GT201300258A patent/GT201300258A/es unknown
- 2013-10-21 DO DO2013000243A patent/DOP2013000243A/es unknown
- 2013-10-24 CO CO13252716A patent/CO6801757A2/es active IP Right Grant
- 2013-11-22 EC ECSP13013038 patent/ECSP13013038A/es unknown
-
2014
- 2014-07-08 US US14/325,420 patent/US20140323730A1/en not_active Abandoned
-
2015
- 2015-01-09 US US14/593,370 patent/US20150112068A1/en not_active Abandoned
- 2015-08-07 US US14/820,884 patent/US20150336958A1/en not_active Abandoned
- 2015-12-21 HR HRP20151397TT patent/HRP20151397T1/hr unknown
-
2016
- 2016-01-14 CY CY20161100038T patent/CY1117122T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR086198A1 (es) | Inhibidores sustituidos de acetil-coa carboxilasa y composiciones farmaceuticas que los contienen | |
| AR070828A1 (es) | Derivados de azetidina y ciclobutano como inhibidores de jak | |
| AR083578A1 (es) | INHIBIDORES DE N/N-LACTAMA ACETIL-CoA CARBOXILASA | |
| AR078944A1 (es) | Inhibidores de n1-pirazoloespirocetona acetil-coa carboxilasa | |
| EA201591429A1 (ru) | 2,3-дизамещенные производные 1-ацил-4-амино-1,2,3,4-тетрагидрохинолинов и их применение в качестве ингибиторов бромодомена | |
| AR094312A1 (es) | Inhibidores del receptor del factor de crecimiento de fibroblastos | |
| AR085960A1 (es) | 1,3-oxazinas como inhibidores de la bace1 y/o de la bace2 | |
| AR105845A1 (es) | Compuestos de heteroarilo bicíclicos fusionados como moduladores de la función irak4 | |
| AR095311A1 (es) | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidores de idh mutante | |
| AR069480A1 (es) | Derivados de 2-amino-pirimidina | |
| PE20142456A1 (es) | COMPUESTOS DE OXAZOLIDIN-2-ONA Y USOS DE LOS MISMOS COMO INHIBIDORES DE LA PI3Ks | |
| EA200801160A1 (ru) | Алкоксиалкилзамещённые спироциклические тетрамовые и тетроновые кислоты | |
| PE20212247A1 (es) | Compuestos de 3-((3-aminofenil)amino)piperidina-2,6-diona sustituida, composiciones de estos y metodos de tratamiento con estos | |
| PE20151781A1 (es) | Piridonamidas como moduladores de canales de sodio | |
| PE20130279A1 (es) | Compuestos heteroarilo nitrogenados | |
| AR076435A1 (es) | Compuestos de indazoles sustituidos, composiciones farmaceuticas que los contienen y procesos de obtencion de los mismos | |
| PE20151602A1 (es) | SALES DE DERIVADOS DE 2-AMINO-1-HIDROXIETIL-8-HIDROXIQUINOLIN-2(1H)-ONA QUE TIENEN ACTIVIDAD AGONISTA DEL RECEPTOR B(beta)2 ADRENERGICO ASI COMO ACTIVIDAD ANTAGONISTA DEL RECEPTOR MUSCARINICO M3 | |
| CO2017001178A2 (es) | Derivado de piridona que tiene un grupo tetrahidropiranil metilo | |
| PE20161405A1 (es) | Analogos de cortistatina y sintesis y usos de los mismos | |
| AR091519A1 (es) | Inhibidores pirrolopirazona de tanquirasa | |
| AR073136A1 (es) | Compuestos de pirrol | |
| AR083872A1 (es) | Derivados de acido carbamoil-cicloalquil-acetico sustituidos como inhibidores de nep | |
| AR118706A2 (es) | Compuesto para el control de plagas y vegetación no deseada, procedimiento para prepararlo, composición que lo comprende, y compuesto intermediario relacionado | |
| AR091271A1 (es) | Pirrolopirimidona y pirrolopiridona, inhibidores de tanquirasa | |
| EA201692305A1 (ru) | Антибактериальные хиназолин-4(3н)-оновые производные |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |