CL2015002520A1 - Compuestos novedosos de pirimidina y piridina y su uso. - Google Patents
Compuestos novedosos de pirimidina y piridina y su uso.Info
- Publication number
- CL2015002520A1 CL2015002520A1 CL2015002520A CL2015002520A CL2015002520A1 CL 2015002520 A1 CL2015002520 A1 CL 2015002520A1 CL 2015002520 A CL2015002520 A CL 2015002520A CL 2015002520 A CL2015002520 A CL 2015002520A CL 2015002520 A1 CL2015002520 A1 CL 2015002520A1
- Authority
- CL
- Chile
- Prior art keywords
- pyridine compounds
- novel pyrimidine
- pyrimidine
- novel
- fgfr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
La presente invención se refiere a compuestos derivados de pirimidina y piridina sustituidas de fórmula (I) o a una sal farmacéuticamente aceptable de los mismos, en donde R1, R2, R3, R4, R5, X, Y y G son como se definen en la descripción; al proceso de preparación de los mismos, a las composiciones farmacéuticas que los comprenden y a su uso en la terapia de una enfermedad sensible a la inhibición de FGFR, tal como el cáncer.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2013/072690 WO2014139145A1 (en) | 2013-03-15 | 2013-03-15 | Novel pyrimidine and pyridine compounds and usage thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2015002520A1 true CL2015002520A1 (es) | 2016-03-28 |
Family
ID=51535826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2015002520A CL2015002520A1 (es) | 2013-03-15 | 2015-09-08 | Compuestos novedosos de pirimidina y piridina y su uso. |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US20160052926A1 (es) |
| EP (1) | EP2970120B1 (es) |
| JP (1) | JP6109969B2 (es) |
| KR (1) | KR101697982B1 (es) |
| CN (1) | CN105143185B (es) |
| AR (1) | AR095430A1 (es) |
| AU (1) | AU2014231437B2 (es) |
| BR (1) | BR112015020772B1 (es) |
| CA (1) | CA2900748C (es) |
| CL (1) | CL2015002520A1 (es) |
| CY (1) | CY1121804T1 (es) |
| DK (1) | DK2970120T3 (es) |
| EA (1) | EA028654B1 (es) |
| ES (1) | ES2697697T3 (es) |
| HK (1) | HK1212687A1 (es) |
| HR (1) | HRP20181906T1 (es) |
| IL (1) | IL240790B (es) |
| LT (1) | LT2970120T (es) |
| MX (1) | MX363397B (es) |
| MY (1) | MY192641A (es) |
| NZ (1) | NZ711460A (es) |
| PE (1) | PE20151601A1 (es) |
| PH (1) | PH12015502047B1 (es) |
| PL (1) | PL2970120T3 (es) |
| PT (1) | PT2970120T (es) |
| RS (1) | RS58136B1 (es) |
| SG (1) | SG11201506280SA (es) |
| SI (1) | SI2970120T1 (es) |
| TW (1) | TWI618698B (es) |
| UA (1) | UA113470C2 (es) |
| WO (2) | WO2014139145A1 (es) |
| ZA (1) | ZA201505999B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2015DN03235A (es) | 2012-11-07 | 2015-10-02 | Karus Therapeutics Ltd | |
| JP6437452B2 (ja) | 2013-01-14 | 2018-12-12 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｐｉｍキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物 |
| ME03780B (me) | 2013-01-15 | 2021-04-20 | Incyte Holdings Corp | Jedinjenja tiazolkarboksamida i piridinkarboksamida korisna kao inhibitori pim kinaze |
| PT2994465T (pt) | 2013-05-10 | 2018-10-25 | Karus Therapeutics Ltd | Novos inibidores de histona desacetilase |
| WO2015027124A1 (en) | 2013-08-23 | 2015-02-26 | Incyte Corporation | Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| GB201419264D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| US9540347B2 (en) | 2015-05-29 | 2017-01-10 | Incyte Corporation | Pyridineamine compounds useful as Pim kinase inhibitors |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| TW201718546A (zh) | 2015-10-02 | 2017-06-01 | 英塞特公司 | 適用作pim激酶抑制劑之雜環化合物 |
| WO2018072707A1 (zh) * | 2016-10-18 | 2018-04-26 | 保诺科技（北京）有限公司 | 芳香族醚类衍生物、其制备方法及其在医药上的应用 |
| NZ754218A (en) | 2016-11-17 | 2021-07-30 | Guangdong Zhongsheng Pharmaceutical Co Ltd | Fgfr4 inhibitor and preparation method and use thereof |
| CN108503593B (zh) * | 2017-02-28 | 2021-04-27 | 暨南大学 | 2-氨基嘧啶类化合物及其应用 |
| CN108570032B (zh) * | 2017-03-09 | 2021-04-02 | 华东理工大学 | 新型罗丹明染料及其在抗致病菌中的应用 |
| CN107382836A (zh) * | 2017-08-04 | 2017-11-24 | 吴赣药业（苏州）有限公司 | 一种1‑(4‑氨基苯基)‑1h‑吡啶‑2‑酮的制备方法 |
| US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| AR120202A1 (es) | 2019-10-14 | 2022-02-02 | Hutchison Medipharma Ltd | Sales del compuesto 4-cloro-3-(2-(2-((4-((3s,5r)-3,5-dimetilpiperazin-1-il)fenil)amino)pirimidin-5-il)etil)-5-metoxi-n-metilbenzamida y formas cristalinas de las mismas |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004021558D1 (de) * | 2003-01-17 | 2009-07-30 | Warner Lambert Co | 2-aminopyridin-substituierteheterocyclen als inhibitoren der zellulären proliferation |
| WO2005002673A1 (en) * | 2003-07-03 | 2005-01-13 | Astex Therapeutics Limited | Raf kinase inhibitors |
| US7776869B2 (en) * | 2004-10-18 | 2010-08-17 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
| EP1863794A2 (en) * | 2005-03-16 | 2007-12-12 | Targegen, Inc. | Pyrimidine compounds and methods of use |
| WO2007056075A2 (en) * | 2005-11-02 | 2007-05-18 | Targegen, Inc. | Six membered heteroaromatic inhibitors targeting resistant kinase mutations |
| US8030487B2 (en) * | 2006-07-07 | 2011-10-04 | Targegen, Inc. | 2-amino—5-substituted pyrimidine inhibitors |
| CN101600714B (zh) | 2006-11-10 | 2013-08-21 | 百时美施贵宝公司 | 吡咯并吡啶激酶抑制剂 |
| EP2022785A1 (en) * | 2007-06-20 | 2009-02-11 | Bayer Schering Pharma Aktiengesellschaft | Alkynylpyrimidines as Tie2 kinase inhibitors |
| KR20110020904A (ko) * | 2008-06-19 | 2011-03-03 | 아스트라제네카 아베 | 피라졸 화합물 436 |
| MX2011007864A (es) * | 2009-01-28 | 2011-09-30 | Karus Therapeutics Ltd | Isosteros para realzar la transcripcion y su uso en terapia. |
| WO2013129369A1 (ja) | 2012-02-28 | 2013-09-06 | アステラス製薬株式会社 | 含窒素芳香族へテロ環化合物 |
| CN104379740B (zh) | 2012-03-08 | 2019-05-14 | 安斯泰来制药株式会社 | 新型fgfr3融合体 |
-
2013
- 2013-03-15 US US14/775,649 patent/US20160052926A1/en not_active Abandoned
- 2013-03-15 WO PCT/CN2013/072690 patent/WO2014139145A1/en active Application Filing
-
2014
- 2014-03-12 TW TW103108613A patent/TWI618698B/zh active
- 2014-03-13 AR ARP140100975A patent/AR095430A1/es active IP Right Grant
- 2014-03-14 ES ES14764299T patent/ES2697697T3/es active Active
- 2014-03-14 MX MX2015012363A patent/MX363397B/es unknown
- 2014-03-14 CA CA2900748A patent/CA2900748C/en active Active
- 2014-03-14 CN CN201480015314.7A patent/CN105143185B/zh active Active
- 2014-03-14 KR KR1020157027380A patent/KR101697982B1/ko active IP Right Grant
- 2014-03-14 SI SI201430969T patent/SI2970120T1/sl unknown
- 2014-03-14 AU AU2014231437A patent/AU2014231437B2/en active Active
- 2014-03-14 JP JP2015561928A patent/JP6109969B2/ja active Active
- 2014-03-14 RS RS20181394A patent/RS58136B1/sr unknown
- 2014-03-14 BR BR112015020772-3A patent/BR112015020772B1/pt active IP Right Grant
- 2014-03-14 NZ NZ711460A patent/NZ711460A/en unknown
- 2014-03-14 MY MYPI2015703158A patent/MY192641A/en unknown
- 2014-03-14 LT LTEP14764299.5T patent/LT2970120T/lt unknown
- 2014-03-14 US US14/775,653 patent/US9701680B2/en active Active
- 2014-03-14 EA EA201591301A patent/EA028654B1/ru unknown
- 2014-03-14 DK DK14764299.5T patent/DK2970120T3/en active
- 2014-03-14 PE PE2015001855A patent/PE20151601A1/es active IP Right Grant
- 2014-03-14 SG SG11201506280SA patent/SG11201506280SA/en unknown
- 2014-03-14 WO PCT/CN2014/073444 patent/WO2014139465A1/en active Application Filing
- 2014-03-14 UA UAA201509752A patent/UA113470C2/uk unknown
- 2014-03-14 PT PT14764299T patent/PT2970120T/pt unknown
- 2014-03-14 PL PL14764299T patent/PL2970120T3/pl unknown
- 2014-03-14 EP EP14764299.5A patent/EP2970120B1/en active Active
-
2015
- 2015-08-19 ZA ZA2015/05999A patent/ZA201505999B/en unknown
- 2015-08-24 IL IL24079015A patent/IL240790B/en active IP Right Grant
- 2015-09-08 CL CL2015002520A patent/CL2015002520A1/es unknown
- 2015-09-10 PH PH12015502047A patent/PH12015502047B1/en unknown
-
2016
- 2016-01-19 HK HK16100550.4A patent/HK1212687A1/zh unknown
-
2018
- 2018-11-15 HR HRP20181906TT patent/HRP20181906T1/hr unknown
- 2018-11-15 CY CY20181101211T patent/CY1121804T1/el unknown
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