MX363397B - Compuestos novedosos de pirimidina y piridina y su uso. - Google Patents
Compuestos novedosos de pirimidina y piridina y su uso.Info
- Publication number
- MX363397B MX363397B MX2015012363A MX2015012363A MX363397B MX 363397 B MX363397 B MX 363397B MX 2015012363 A MX2015012363 A MX 2015012363A MX 2015012363 A MX2015012363 A MX 2015012363A MX 363397 B MX363397 B MX 363397B
- Authority
- MX
- Mexico
- Prior art keywords
- pyridine compounds
- usage
- novel pyrimidine
- pyrimidine
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a compuestos novedosos de pirimidina y piridina de la formula (I) o una sal farmaceuticamente aceptable del mismo, (ver Fórmula) en donde R1, R2, R3, R4, R5, X, Y y G son como se definen en la descripción, para las composiciones farmaceuticas que los contienen, un proceso para la preparación de los mismos, y su uso en la terapia de una enfermedad sensible a la inhibición de FGFR, por ejemplo, cáncer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2013/072690 WO2014139145A1 (en) | 2013-03-15 | 2013-03-15 | Novel pyrimidine and pyridine compounds and usage thereof |
| PCT/CN2014/073444 WO2014139465A1 (en) | 2013-03-15 | 2014-03-14 | Novel pyrimidine and pyridine compounds and their usage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015012363A MX2015012363A (es) | 2016-02-03 |
| MX363397B true MX363397B (es) | 2019-03-21 |
Family
ID=51535826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015012363A MX363397B (es) | 2013-03-15 | 2014-03-14 | Compuestos novedosos de pirimidina y piridina y su uso. |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US20160052926A1 (es) |
| EP (1) | EP2970120B1 (es) |
| JP (1) | JP6109969B2 (es) |
| KR (1) | KR101697982B1 (es) |
| CN (1) | CN105143185B (es) |
| AR (1) | AR095430A1 (es) |
| AU (1) | AU2014231437B2 (es) |
| BR (1) | BR112015020772B1 (es) |
| CA (1) | CA2900748C (es) |
| CL (1) | CL2015002520A1 (es) |
| CY (1) | CY1121804T1 (es) |
| DK (1) | DK2970120T3 (es) |
| EA (1) | EA028654B1 (es) |
| ES (1) | ES2697697T3 (es) |
| HK (1) | HK1212687A1 (es) |
| HR (1) | HRP20181906T1 (es) |
| IL (1) | IL240790B (es) |
| LT (1) | LT2970120T (es) |
| MX (1) | MX363397B (es) |
| MY (1) | MY192641A (es) |
| NZ (1) | NZ711460A (es) |
| PE (1) | PE20151601A1 (es) |
| PH (1) | PH12015502047A1 (es) |
| PL (1) | PL2970120T3 (es) |
| PT (1) | PT2970120T (es) |
| RS (1) | RS58136B1 (es) |
| SG (1) | SG11201506280SA (es) |
| SI (1) | SI2970120T1 (es) |
| TW (1) | TWI618698B (es) |
| UA (1) | UA113470C2 (es) |
| WO (2) | WO2014139145A1 (es) |
| ZA (1) | ZA201505999B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2917202B1 (en) | 2012-11-07 | 2018-05-02 | Karus Therapeutics Limited | Novel histone deacetylase inhibitors and their use in therapy |
| JP6437452B2 (ja) | 2013-01-14 | 2018-12-12 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｐｉｍキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物 |
| KR102311840B1 (ko) | 2013-01-15 | 2021-10-14 | 인사이트 홀딩스 코포레이션 | Pim 키나제 저해제로서 유용한 티아졸카복스아마이드 및 피리딘카복스아마이드 화합물 |
| AU2014264370B2 (en) | 2013-05-10 | 2017-12-14 | Karus Therapeutics Ltd | Novel histone deacetylase inhibitors |
| TW201605866A (zh) | 2013-08-23 | 2016-02-16 | 英塞特公司 | 可用作ｐｉｍ激酶抑制劑之呋喃并－及噻吩并－吡啶甲醯胺化合物 |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| GB201419264D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| TW201718546A (zh) | 2015-10-02 | 2017-06-01 | 英塞特公司 | 適用作pim激酶抑制劑之雜環化合物 |
| WO2018072707A1 (zh) * | 2016-10-18 | 2018-04-26 | 保诺科技（北京）有限公司 | 芳香族醚类衍生物、其制备方法及其在医药上的应用 |
| MX2019005723A (es) | 2016-11-17 | 2019-10-21 | Guangdong Zhongsheng Pharmaceutical Co Ltd | Inhibidor del receptor del factor de crecimiento de fibroblastos 4 (fgfr4) y metodo de preparacion y uso del mismo. |
| CN108503593B (zh) * | 2017-02-28 | 2021-04-27 | 暨南大学 | 2-氨基嘧啶类化合物及其应用 |
| CN108570032B (zh) * | 2017-03-09 | 2021-04-02 | 华东理工大学 | 新型罗丹明染料及其在抗致病菌中的应用 |
| CN107382836A (zh) * | 2017-08-04 | 2017-11-24 | 吴赣药业（苏州）有限公司 | 一种1‑(4‑氨基苯基)‑1h‑吡啶‑2‑酮的制备方法 |
| AR113922A1 (es) | 2017-12-08 | 2020-07-01 | Incyte Corp | Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas |
| WO2021073494A1 (en) * | 2019-10-14 | 2021-04-22 | Hutchison Medipharma Limited | The salts of a compound and the crystalline forms thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004065378A1 (en) * | 2003-01-17 | 2004-08-05 | Warner-Lambert Company Llc | 2-aminopyridine substituted heterocycles as inhibitors of cellular proliferation |
| WO2005002673A1 (en) * | 2003-07-03 | 2005-01-13 | Astex Therapeutics Limited | Raf kinase inhibitors |
| US7776869B2 (en) * | 2004-10-18 | 2010-08-17 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
| CN101155799A (zh) * | 2005-03-16 | 2008-04-02 | 塔格根公司 | 嘧啶化合物和使用方法 |
| WO2007056023A2 (en) * | 2005-11-02 | 2007-05-18 | Targegen, Inc. | Thiazole inhibitors targeting resistant kinase mutations |
| US8030487B2 (en) * | 2006-07-07 | 2011-10-04 | Targegen, Inc. | 2-amino—5-substituted pyrimidine inhibitors |
| US8148361B2 (en) * | 2006-11-10 | 2012-04-03 | Bristol-Myers Squibb Company | Kinase inhibitors |
| EP2022785A1 (en) * | 2007-06-20 | 2009-02-11 | Bayer Schering Pharma Aktiengesellschaft | Alkynylpyrimidines as Tie2 kinase inhibitors |
| BRPI0914233A2 (pt) * | 2008-06-19 | 2015-11-03 | Astrazeneca Ab | composto, uso de um composto, métodos para produzir um efeito inibidor de fgfr e para produzir um efeito anticâncer em um animal de sangue quente, composição farmacêutica, e, método para tratar uma doença |
| ES2650810T3 (es) * | 2009-01-28 | 2018-01-22 | Karus Therapeutics Limited | Isósteros de Scriptaid y su uso en terapia |
| MX349120B (es) | 2012-02-28 | 2017-07-12 | Astellas Pharma Inc | Compuesto heterociclico aromatico que contiene nitrogeno. |
| ES2702305T3 (es) | 2012-03-08 | 2019-02-28 | Astellas Pharma Inc | Nuevo producto de fusión de FGFR3 |
-
2013
- 2013-03-15 US US14/775,649 patent/US20160052926A1/en not_active Abandoned
- 2013-03-15 WO PCT/CN2013/072690 patent/WO2014139145A1/en active Application Filing
-
2014
- 2014-03-12 TW TW103108613A patent/TWI618698B/zh active
- 2014-03-13 AR ARP140100975A patent/AR095430A1/es active IP Right Grant
- 2014-03-14 DK DK14764299.5T patent/DK2970120T3/en active
- 2014-03-14 SG SG11201506280SA patent/SG11201506280SA/en unknown
- 2014-03-14 BR BR112015020772-3A patent/BR112015020772B1/pt active IP Right Grant
- 2014-03-14 PE PE2015001855A patent/PE20151601A1/es active IP Right Grant
- 2014-03-14 MX MX2015012363A patent/MX363397B/es unknown
- 2014-03-14 KR KR1020157027380A patent/KR101697982B1/ko active IP Right Grant
- 2014-03-14 SI SI201430969T patent/SI2970120T1/sl unknown
- 2014-03-14 UA UAA201509752A patent/UA113470C2/uk unknown
- 2014-03-14 MY MYPI2015703158A patent/MY192641A/en unknown
- 2014-03-14 JP JP2015561928A patent/JP6109969B2/ja active Active
- 2014-03-14 CN CN201480015314.7A patent/CN105143185B/zh active Active
- 2014-03-14 PL PL14764299T patent/PL2970120T3/pl unknown
- 2014-03-14 NZ NZ711460A patent/NZ711460A/en unknown
- 2014-03-14 WO PCT/CN2014/073444 patent/WO2014139465A1/en active Application Filing
- 2014-03-14 PT PT14764299T patent/PT2970120T/pt unknown
- 2014-03-14 EP EP14764299.5A patent/EP2970120B1/en active Active
- 2014-03-14 CA CA2900748A patent/CA2900748C/en active Active
- 2014-03-14 US US14/775,653 patent/US9701680B2/en active Active
- 2014-03-14 LT LTEP14764299.5T patent/LT2970120T/lt unknown
- 2014-03-14 EA EA201591301A patent/EA028654B1/ru unknown
- 2014-03-14 RS RS20181394A patent/RS58136B1/sr unknown
- 2014-03-14 ES ES14764299T patent/ES2697697T3/es active Active
- 2014-03-14 AU AU2014231437A patent/AU2014231437B2/en active Active
-
2015
- 2015-08-19 ZA ZA2015/05999A patent/ZA201505999B/en unknown
- 2015-08-24 IL IL24079015A patent/IL240790B/en active IP Right Grant
- 2015-09-08 CL CL2015002520A patent/CL2015002520A1/es unknown
- 2015-09-10 PH PH12015502047A patent/PH12015502047A1/en unknown
-
2016
- 2016-01-19 HK HK16100550.4A patent/HK1212687A1/zh unknown
-
2018
- 2018-11-15 CY CY20181101211T patent/CY1121804T1/el unknown
- 2018-11-15 HR HRP20181906TT patent/HRP20181906T1/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12015502047A1 (en) | Novel pyrimidine and pyridine compounds and their usage | |
| PH12017502246B1 (en) | New hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them | |
| PH12016501898A1 (en) | Quinoxaline derivatives useful as fgfr kinase modulators | |
| PH12014000179A1 (en) | New pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them | |
| MD20140137A2 (ro) | Derivaţi noi de tienopirimidină, procedeu de preparare a acestora, compoziţii farmaceutice care îi conţin | |
| MX2014002836A (es) | Derivados de aminopirimidina para usarse como moduladores de la actividad de cinasa. | |
| MD4664C9 (ro) | Lactame aril şi heteroaril condensate | |
| JO3160B1 (ar) | مشتقات الفوسفات الجديدة, طريقة تحضيرها والتركيبات الدوائية التي تحتوي عليها | |
| PH12015502737A1 (en) | Novel fused pyrimidine compound or salt thereof | |
| MX2013010898A (es) | Novedoso derivados de la pirimidina. | |
| PH12016500057A1 (en) | Novel indolizine compounds, a process for their preparation and pharmaceutical compositions containing them | |
| BR112012029647A2 (pt) | novos derivados de pirimidinas | |
| PH12016500003A1 (en) | Compounds and compositions as inhibitors of mek | |
| GEP20207108B (en) | Substituted 2,4 diamino-quinoline as new anticancer agents | |
| PH12014501712A1 (en) | Novel morpholinyl derivatives useful as mogat-2-inhibitors | |
| IN2015DN00950A (es) | ||
| GB2527958A (en) | Pregnane-oximino-aminoalkylethers and process for preparation thereof, useful as antidiabetic and antidyslipidemic agents | |
| TN2014000307A1 (en) | Novel morpholinyl derivatives useful as mogat-2 inhibitors |