BR112019001138A2 - proteínas biespecíficas e métodos para preparar as mesmas - Google Patents
proteínas biespecíficas e métodos para preparar as mesmasInfo
- Publication number
- BR112019001138A2 BR112019001138A2 BR112019001138-2A BR112019001138A BR112019001138A2 BR 112019001138 A2 BR112019001138 A2 BR 112019001138A2 BR 112019001138 A BR112019001138 A BR 112019001138A BR 112019001138 A2 BR112019001138 A2 BR 112019001138A2
- Authority
- BR
- Brazil
- Prior art keywords
- heavy chain
- preparing
- domain
- bispecific protein
- methods
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 239000000833 heterodimer Substances 0.000 abstract 3
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
a presente invenção refere-se a uma proteína biespecífica e um método de preparação da mesma e, mais especificamente, a uma proteína biespecífica com uma pureza de heterodímeros que é preparada introduzindo uma mutação em uma cadeia pesada e/ou cadeia leve para, assim aumentar uma taxa de formação de heterodímero entre uma cadeia pesada (domínio ch3 ou fc) e uma cadeia pesada (domínio ch3 ou fc) e aumentar uma taxa de formação de heterodímero entre cadeias direcionadas ao mesmo material entre uma cadeia pesada (domínio ch1) e uma cadeia leve. a proteína biespecífica de acordo com a presente invenção é útil em vários campos, tais como, tratamento de câncer, regulação de sinal, diagnóstico, etc.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2016-0091157 | 2016-07-19 | ||
| KR20160091157 | 2016-07-19 | ||
| PCT/KR2017/007791 WO2018016881A1 (ko) | 2016-07-19 | 2017-07-19 | 이중 특이성 단백질 및 이의 제조 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019001138A2 true BR112019001138A2 (pt) | 2019-04-30 |
Family
ID=60992392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019001138-2A BR112019001138A2 (pt) | 2016-07-19 | 2017-07-19 | proteínas biespecíficas e métodos para preparar as mesmas |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20230075499A1 (pt) |
| EP (1) | EP3489262A4 (pt) |
| JP (2) | JP2019530641A (pt) |
| KR (4) | KR102098919B1 (pt) |
| CN (2) | CN109476763B (pt) |
| AU (3) | AU2017298535B2 (pt) |
| BR (1) | BR112019001138A2 (pt) |
| CA (2) | CA3203613A1 (pt) |
| IL (1) | IL264249B2 (pt) |
| MX (1) | MX2019000925A (pt) |
| MY (1) | MY200137A (pt) |
| PH (1) | PH12019500138A1 (pt) |
| RU (1) | RU2745648C2 (pt) |
| SA (1) | SA519400924B1 (pt) |
| SG (1) | SG11201900373WA (pt) |
| WO (1) | WO2018016881A1 (pt) |
| ZA (1) | ZA201900347B (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101398363B1 (ko) | 2010-11-17 | 2014-05-22 | 추가이 세이야쿠 가부시키가이샤 | 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자 |
| US11851476B2 (en) | 2011-10-31 | 2023-12-26 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain |
| JP6496095B1 (ja) | 2017-09-29 | 2019-04-03 | 中外製薬株式会社 | 血液凝固第ｖｉｉｉ因子（ｆｖｉｉｉ）補因子機能代替活性を有する多重特異性抗原結合分子および当該分子を有効成分として含有する薬学的製剤 |
| CN113795516A (zh) * | 2019-03-28 | 2021-12-14 | Ab工作室有限公司 | 异多聚体蛋白质及其使用方法 |
| CA3132275A1 (en) * | 2019-04-25 | 2020-10-29 | Ulrich Brinkmann | Generation of antibody-derived polypeptides by polypeptide chain exchange |
| KR20220107163A (ko) * | 2019-09-30 | 2022-08-02 | 아디맵 엘엘씨 | 우선적으로 경쇄 페어링하도록 조작된 ch1 도메인 변이체 및 이를 포함하는 다중특이적 항체 |
| CN112646041B (zh) * | 2019-10-12 | 2023-11-10 | 上海睿智化学研究有限公司 | 包含抗体ch3域的异源二聚体及含其的抗体、融合蛋白 |
| CN113121696A (zh) * | 2019-12-31 | 2021-07-16 | 周易 | Fab改造诱导形成的双特异性抗体及其制备方法和用途 |
| CN115279796A (zh) * | 2020-01-23 | 2022-11-01 | 天演药业(瑞士)公司 | 具有Fc突变的异二聚蛋白质 |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| GB202005879D0 (en) * | 2020-04-22 | 2020-06-03 | Petmedix Ltd | Heterodimeric proteins |
| MX2022014208A (es) * | 2020-05-21 | 2022-12-07 | Merus Nv | Metodos y medios para la produccion de moleculas tipo ig. |
| WO2021246720A1 (ko) | 2020-06-01 | 2021-12-09 | 머스트바이오 주식회사 | 이중특이 항체 또는 그의 항원-결합 단편 및 이를 제조하는 방법 |
| CN114437226A (zh) * | 2020-11-05 | 2022-05-06 | 杭州菁因康生物科技有限公司 | 制备双特异性抗体的方法 |
| CA3167854A1 (en) * | 2020-12-03 | 2022-06-09 | Eric Escobar-Cabrera | Heterodimeric iga fc constructs and methods of use thereof |
| US20230116446A1 (en) * | 2021-09-21 | 2023-04-13 | Qilu Puget Sound Biotherapeutics Corporation | HETERODIMERIC Fc FOR MAKING FUSION PROTEINS AND BISPECIFIC ANTIBODIES |
| CN117586413A (zh) * | 2022-08-09 | 2024-02-23 | 三生国健药业（上海）股份有限公司 | 异多聚体蛋白质及其制备方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2614181A1 (en) * | 2005-07-01 | 2007-01-11 | Medimmune, Inc. | An integrated approach for generating multidomain protein therapeutics |
| MY147651A (en) * | 2007-07-31 | 2012-12-31 | Regeneron Pharma | Human antibodies to human cd20 and method of using thereof |
| JP5761997B2 (ja) * | 2007-12-14 | 2015-08-12 | ブリストル−マイヤーズ・スクイブ・カンパニー | ヒトｏｘ４０受容体に対する結合分子 |
| HUE028536T2 (en) * | 2008-01-07 | 2016-12-28 | Amgen Inc | Method for producing antibody to FC heterodimer molecules using electrostatic control effects |
| EP2603526A1 (en) * | 2010-08-13 | 2013-06-19 | Medimmune Limited | Monomeric polypeptides comprising variant fc regions and methods of use |
| RS59589B1 (sr) * | 2010-11-05 | 2019-12-31 | Zymeworks Inc | Dizajniranje stabilnog heterodimernog antitela sa mutacijama u fc domenu |
| AU2012227883A1 (en) | 2011-03-17 | 2013-10-24 | Ramot At Tel-Aviv University Ltd. | Bi- and monospecific, asymmetric antibodies and methods of generating the same |
| CN107840894A (zh) * | 2011-03-25 | 2018-03-27 | 格兰马克药品股份有限公司 | 异二聚体免疫球蛋白 |
| EA016517B1 (ru) * | 2011-04-05 | 2012-05-30 | Федеральное Государственное Бюджетное Учреждение "Научно-Исследовательский Институт Эпидемиологии И Микробиологии Имени Почетного Академика Н.Ф. Гамалеи" Министерства Здравоохранения И Социального Развития Российской Федерации | Рекомбинантная псевдоаденовирусная наночастица, фармацевтическая композиция для профилактики или терапии гриппа (варианты), способ профилактики или терапии гриппа |
| CA2832389A1 (en) * | 2011-04-20 | 2012-10-26 | Genmab A/S | Bispecific antibodies against her2 and cd3 |
| EP2543680A1 (en) * | 2011-07-07 | 2013-01-09 | Centre National de la Recherche Scientifique | Multispecific mutated antibody Fab fragments |
| EP3674320A3 (en) * | 2011-10-27 | 2020-08-12 | Genmab A/S | Production of heterodimeric proteins |
| US11851476B2 (en) * | 2011-10-31 | 2023-12-26 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain |
| WO2013089496A1 (ko) * | 2011-12-15 | 2013-06-20 | (주)에이프로젠 | H1n1-감염된 환자들로부터 유도된 매우 잠재력 있는 넓은-스펙트럼 중화 단일클론 항체 및 이를 포함하는 바이러스의 치료용 조성물 |
| JP6351572B2 (ja) * | 2012-05-10 | 2018-07-04 | ザイムワークス，インコーポレイテッド | Ｆｃドメインに突然変異を有する免疫グロブリン重鎖のヘテロ多量体構築物 |
| UY35148A (es) * | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| EA032681B1 (ru) * | 2012-11-27 | 2019-07-31 | Аджоу Юниверсити Индастри-Академик Кооперейшн Фаундейшн | ГЕТЕРОДИМЕР Fc ИММУНОГЛОБУЛИНА, СОДЕРЖАЩИЙ ВАРИАНТ ДОМЕНА CH3 ДЛЯ ОБРАЗОВАНИЯ АНТИТЕЛА ИЛИ ГИБРИДНОГО БЕЛКА С ГЕТЕРОМЕРНЫМ Fc С ВЫСОКОЙ ЭФФЕКТИВНОСТЬЮ, СПОСОБ ДЛЯ ЕГО ПОЛУЧЕНИЯ И ИСПОЛЬЗОВАНИЯ |
| US10738132B2 (en) * | 2013-01-14 | 2020-08-11 | Xencor, Inc. | Heterodimeric proteins |
| JP6499087B2 (ja) * | 2013-02-26 | 2019-04-10 | ロシュ グリクアート アーゲー | 二重特異性ｔ細胞活性化抗原結合分子 |
| US10118971B2 (en) * | 2013-03-13 | 2018-11-06 | Ibentrus, Inc. | Protein in which electrical interaction is introduced within hydrophobic interaction site and preparation method therefor |
| JP2017518965A (ja) * | 2014-05-02 | 2017-07-13 | モメンタ ファーマシューティカルズ インコーポレイテッ | エンジニアリングされたＦｃ構築物に関連する組成物および方法 |
| EP3701969A1 (en) * | 2014-10-31 | 2020-09-02 | NGM Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
| CN110894240B (zh) * | 2014-11-26 | 2022-04-15 | 森科股份有限公司 | 结合cd3和肿瘤抗原的异二聚体抗体 |
| AU2015353416C1 (en) * | 2014-11-26 | 2022-01-27 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and CD38 |
| US20160176969A1 (en) * | 2014-11-26 | 2016-06-23 | Xencor, Inc. | Heterodimeric antibodies including binding to cd8 |
| US10982008B2 (en) * | 2014-12-05 | 2021-04-20 | Merck Patent Gmbh | Domain-exchanged antibody |
-
2017
- 2017-07-19 CN CN201780044935.1A patent/CN109476763B/zh active Active
- 2017-07-19 WO PCT/KR2017/007791 patent/WO2018016881A1/ko active Application Filing
- 2017-07-19 SG SG11201900373WA patent/SG11201900373WA/en unknown
- 2017-07-19 MY MYPI2018002707A patent/MY200137A/en unknown
- 2017-07-19 BR BR112019001138-2A patent/BR112019001138A2/pt unknown
- 2017-07-19 US US16/317,987 patent/US20230075499A1/en active Pending
- 2017-07-19 EP EP17831354.0A patent/EP3489262A4/en active Pending
- 2017-07-19 MX MX2019000925A patent/MX2019000925A/es unknown
- 2017-07-19 AU AU2017298535A patent/AU2017298535B2/en active Active
- 2017-07-19 CA CA3203613A patent/CA3203613A1/en active Pending
- 2017-07-19 CN CN202311086544.XA patent/CN117143247A/zh active Pending
- 2017-07-19 CA CA3031082A patent/CA3031082C/en active Active
- 2017-07-19 RU RU2019103238A patent/RU2745648C2/ru active
- 2017-07-19 KR KR1020170091758A patent/KR102098919B1/ko active IP Right Grant
- 2017-07-19 JP JP2019502596A patent/JP2019530641A/ja active Pending
-
2019
- 2019-01-15 IL IL264249A patent/IL264249B2/en unknown
- 2019-01-17 SA SA519400924A patent/SA519400924B1/ar unknown
- 2019-01-17 ZA ZA2019/00347A patent/ZA201900347B/en unknown
- 2019-01-18 PH PH12019500138A patent/PH12019500138A1/en unknown
-
2020
- 2020-04-02 KR KR1020200040498A patent/KR20200042883A/ko not_active Application Discontinuation
- 2020-04-02 KR KR1020200040499A patent/KR102207260B1/ko active IP Right Grant
- 2020-04-02 KR KR1020200040500A patent/KR102207261B1/ko active IP Right Grant
-
2021
- 2021-01-22 AU AU2021200412A patent/AU2021200412A1/en not_active Abandoned
- 2021-05-26 JP JP2021088111A patent/JP7335634B2/ja active Active
-
2024
- 2024-07-01 AU AU2024204558A patent/AU2024204558A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112019001138A2 (pt) | proteínas biespecíficas e métodos para preparar as mesmas | |
| ECSP17083788A (es) | Anticuerpos anti-cd38 para el tratamiento de amiloidosis de cadena ligera y otras enfermedades malignas hematológicas positivas para cd38 | |
| CO2018001485A2 (es) | Diacuerpos monovalentes biespecificos que son capaces de unirse a b7 - h3 y cd3 | |
| BR112018070377A2 (pt) | inibidores macrocíclicos das interações de proteína/proteína pd-1/pd-l1 e cd80/pd-l1 | |
| CL2017000311A1 (es) | Anticuerpos anti-lag3 y fragmentos de unión a antígeno | |
| UY37143A (es) | Compuestos macrocíclicos útiles como inmunomoduladores de las interacciones proteína/proteína pd-1/pd-l1 y cd80/pd-l1 | |
| UY36419A (es) | Composiciones farmacéuticas que contienen anticuerpos anti-cd38 para el tratamiento de la leucemia mieloide aguda | |
| UY36471A (es) | Anticuerpos contra el inmunorreceptor (tigit) de linfocitos t con dominios ig y motivos de inhibición del inmunorreceptor basados en tirosina (itim) | |
| CU20170116A7 (es) | Compuestos cíclicos terapéuticos como inmunomoduladores | |
| EA201791621A1 (ru) | 3-замещенные-1,2,4-оксадиазольные и тиадиазольные соединения в качестве иммуномодуляторов | |
| TR201901445T4 (tr) | Il2rbeta/yaygın gamma zinciri antikorları. | |
| EA201991598A1 (ru) | СОЕДИНЕНИЯ, МОДУЛИРУЮЩИЕ АРИЛУГЛЕВОДОРОДНЫЙ РЕЦЕПТОР (AhR) | |
| PE20160690A1 (es) | Anticuerpos anti-cd134 (ox40) humanizados y usos de los mismos | |
| EA201891732A1 (ru) | Биспецифичные связывающие белки для pd-l1 и kdr | |
| ECSP17038999A (es) | 4-oxo-3,4-dihidro-1,2,3-benzotriazinas como moduladores de gpr139 | |
| EA201691541A1 (ru) | Новые анти-baff антитела | |
| MX2023010076A (es) | Moleculas de union al transcrito 7 similar a inmunoglobulina (ilt7) y metodos de uso de las mismas. | |
| CU20190067A7 (es) | Compuestos químicos derivados sustituidos de 1h-pirrolo [3,2-c] piridinas como moduladores del receptor de hidrocarburos de arilo (ahr) | |
| EA201892225A1 (ru) | АНТИТЕЛА К ФАКТОРУ Bb КОМПЛЕМЕНТА И ИХ ПРИМЕНЕНИЕ | |
| PE20170193A1 (es) | Derivados de 6-alquinil-piridina | |
| CY1122728T1 (el) | Αντισωματα εναντι hpa-1a | |
| ECSP16074207A (es) | Pirazinas moduladoras de gpr6 | |
| EA201690936A1 (ru) | Применение цистеамина и его производных для лечения митохондриальных заболеваний | |
| EA201890347A1 (ru) | Антитела и исследования для обнаружения cd37 | |
| EA201690383A1 (ru) | НОВЫЕ АНТИТЕЛА К FC-γ-РЕЦЕПТОРУ IIB И ИХ ПРИМЕНЕНИЯ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] |