UY37143A - Compuestos macrocíclicos útiles como inmunomoduladores de las interacciones proteína/proteína pd-1/pd-l1 y cd80/pd-l1 - Google Patents

Compuestos macrocíclicos útiles como inmunomoduladores de las interacciones proteína/proteína pd-1/pd-l1 y cd80/pd-l1

Info

Publication number
UY37143A
UY37143A UY0001037143A UY37143A UY37143A UY 37143 A UY37143 A UY 37143A UY 0001037143 A UY0001037143 A UY 0001037143A UY 37143 A UY37143 A UY 37143A UY 37143 A UY37143 A UY 37143A
Authority
UY
Uruguay
Prior art keywords
protein
immunomodulators
macrocyclic compounds
useful
interactions
Prior art date
Application number
UY0001037143A
Other languages
English (en)
Inventor
Matthew Miller Michael
A Meanwell Nicholas
Patrick Allen Martin
P Gillis Eric
R Langley David
Eric Mull
Sun Li-Qiang
Yeung Kap-Sun
A Grant-Young Katharine
Michael Scola Paul
Original Assignee
Bristol-Myers Squibb Company Una Corporación Del Estado De Delaware
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company Una Corporación Del Estado De Delaware filed Critical Bristol-Myers Squibb Company Una Corporación Del Estado De Delaware
Publication of UY37143A publication Critical patent/UY37143A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente descripción proporciona compuestos macrocíclicos novedosos que inhiben y/o modulan las interacciones proteína/proteína PD-1/PD-L1 y PD-L1/CD80, útiles para la mejora de distintas enfermedades, que incluyen el cáncer y las enfermedades infecciosas.
UY0001037143A 2016-03-04 2017-03-03 Compuestos macrocíclicos útiles como inmunomoduladores de las interacciones proteína/proteína pd-1/pd-l1 y cd80/pd-l1 UY37143A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662303673P 2016-03-04 2016-03-04

Publications (1)

Publication Number Publication Date
UY37143A true UY37143A (es) 2017-08-31

Family

ID=58347940

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001037143A UY37143A (es) 2016-03-04 2017-03-03 Compuestos macrocíclicos útiles como inmunomoduladores de las interacciones proteína/proteína pd-1/pd-l1 y cd80/pd-l1

Country Status (19)

Country Link
US (1) US10143746B2 (es)
EP (1) EP3423470B1 (es)
JP (1) JP6976263B2 (es)
KR (1) KR102409246B1 (es)
CN (1) CN109153703B (es)
AR (1) AR107802A1 (es)
AU (1) AU2017227777B2 (es)
BR (1) BR112018017114A2 (es)
CA (1) CA3016024A1 (es)
CL (1) CL2018002506A1 (es)
CO (1) CO2018010316A2 (es)
EA (1) EA035134B1 (es)
ES (1) ES2886635T3 (es)
IL (1) IL261408B (es)
MX (1) MX2018010414A (es)
SG (1) SG11201807426WA (es)
TW (1) TW201734022A (es)
UY (1) UY37143A (es)
WO (1) WO2017151830A1 (es)

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Publication number Publication date
IL261408A (en) 2018-10-31
AU2017227777B2 (en) 2021-07-01
CL2018002506A1 (es) 2018-11-09
EP3423470A1 (en) 2019-01-09
EP3423470B1 (en) 2021-08-18
SG11201807426WA (en) 2018-09-27
KR102409246B1 (ko) 2022-06-14
CO2018010316A2 (es) 2018-10-22
AU2017227777A1 (en) 2018-10-25
AR107802A1 (es) 2018-06-06
MX2018010414A (es) 2018-11-09
EA035134B1 (ru) 2020-04-30
KR20180118724A (ko) 2018-10-31
US10143746B2 (en) 2018-12-04
CA3016024A1 (en) 2017-09-08
WO2017151830A1 (en) 2017-09-08
BR112018017114A2 (pt) 2018-12-26
CN109153703B (zh) 2022-09-23
JP2019512478A (ja) 2019-05-16
CN109153703A (zh) 2019-01-04
TW201734022A (zh) 2017-10-01
US20170252432A1 (en) 2017-09-07
EA201891879A1 (ru) 2019-02-28
JP6976263B2 (ja) 2021-12-08
ES2886635T3 (es) 2021-12-20
IL261408B (en) 2022-01-01

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