CL2017000312A1 - Elección de microarn como diana para trastornos metabólicos - Google Patents

Elección de microarn como diana para trastornos metabólicos

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Publication number
CL2017000312A1
CL2017000312A1 CL2017000312A CL2017000312A CL2017000312A1 CL 2017000312 A1 CL2017000312 A1 CL 2017000312A1 CL 2017000312 A CL2017000312 A CL 2017000312A CL 2017000312 A CL2017000312 A CL 2017000312A CL 2017000312 A1 CL2017000312 A1 CL 2017000312A1
Authority
CL
Chile
Prior art keywords
microarn
choice
target
metabolic disorders
mir
Prior art date
Application number
CL2017000312A
Other languages
English (en)
Inventor
Balkrishen Bhat
Neil W Gibson
Deidre Mackenna
Brandee Wagner
David Bartel
Original Assignee
Regulus Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53836884&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2017000312(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regulus Therapeutics Inc filed Critical Regulus Therapeutics Inc
Publication of CL2017000312A1 publication Critical patent/CL2017000312A1/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/10—Type of nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications
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    • C12N2320/00—Applications; Uses
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Abstract

<p>EN LA PRESENTE SE DESCRIBEN COMPUESTOS QUE COMPRENDEN OLIGONUCLEÓTIDOS MODIFICADOS QUE SON COMPLEMENTARIOS A MIR-1 03 Y/O MIR-1 07 Y MÉTODOS PARA TRATAR ENFERMEDADES Y TRASTORNOS UTILIZANDO LOS COMPUESTOS.</p>
CL2017000312A 2014-08-07 2017-02-07 Elección de microarn como diana para trastornos metabólicos CL2017000312A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462034739P 2014-08-07 2014-08-07
US201462062749P 2014-10-10 2014-10-10
US201562143434P 2015-04-06 2015-04-06

Publications (1)

Publication Number Publication Date
CL2017000312A1 true CL2017000312A1 (es) 2017-10-06

Family

ID=53836884

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017000312A CL2017000312A1 (es) 2014-08-07 2017-02-07 Elección de microarn como diana para trastornos metabólicos

Country Status (17)

Country Link
US (4) US9487783B2 (es)
EP (1) EP3177721A1 (es)
JP (1) JP2017523790A (es)
KR (1) KR20170033439A (es)
CN (1) CN106559995A (es)
AU (1) AU2015301057A1 (es)
BR (1) BR112017001931A2 (es)
CA (1) CA2953883A1 (es)
CL (1) CL2017000312A1 (es)
CO (1) CO2017000950A2 (es)
IL (1) IL249819A0 (es)
MA (1) MA40463A (es)
MX (1) MX2017001493A (es)
RU (1) RU2017105342A (es)
SG (1) SG11201610877PA (es)
TW (1) TW201613949A (es)
WO (1) WO2016022753A1 (es)

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KR102287532B1 (ko) 2014-01-30 2021-08-11 에프. 호프만-라 로슈 아게 생분해성 컨쥬게이트를 갖는 폴리 올리고머 화합물
CN106559995A (zh) 2014-08-07 2017-04-05 莱古路斯治疗法股份有限公司 靶向代谢紊乱的微小rna

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US20160046940A1 (en) 2016-02-18
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