BR112018070377A2 - inibidores macrocíclicos das interações de proteína/proteína pd-1/pd-l1 e cd80/pd-l1 - Google Patents

inibidores macrocíclicos das interações de proteína/proteína pd-1/pd-l1 e cd80/pd-l1

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Publication number
BR112018070377A2
BR112018070377A2 BR112018070377A BR112018070377A BR112018070377A2 BR 112018070377 A2 BR112018070377 A2 BR 112018070377A2 BR 112018070377 A BR112018070377 A BR 112018070377A BR 112018070377 A BR112018070377 A BR 112018070377A BR 112018070377 A2 BR112018070377 A2 BR 112018070377A2
Authority
BR
Brazil
Prior art keywords
protein
interactions
macrocyclic inhibitors
macrocyclic
inhibitors
Prior art date
Application number
BR112018070377A
Other languages
English (en)
Inventor
Matthew Miller Michael
Patrick Allen Martin
Li Ling
S. Bowsher Michael
P. Gillis Eric
Mull Eric
Zhao Qian
Sun Li-Qiang
R. Langley David
Michael Scola Paul
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of BR112018070377A2 publication Critical patent/BR112018070377A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

a presente invenção refere-se a novos peptídeos macrocíclicos que inibem a interação de proteína/proteína pd-1/pd-ll e pd-l1/cd80, e desse modo são úteis para a melhora de várias doenças, incluindo câncer e doenças infecciosas, em que: a é selecionado de uma ligação.
BR112018070377A 2016-04-05 2017-04-03 inibidores macrocíclicos das interações de proteína/proteína pd-1/pd-l1 e cd80/pd-l1 BR112018070377A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662318417P 2016-04-05 2016-04-05
US15/475,227 US10358463B2 (en) 2016-04-05 2017-03-31 Immunomodulators
PCT/US2017/025677 WO2017176608A1 (en) 2016-04-05 2017-04-03 Macrocyclic inhibitors of the pd-1/pd-l1 and cd80/pd-l1 protein/protein interactions

Publications (1)

Publication Number Publication Date
BR112018070377A2 true BR112018070377A2 (pt) 2019-02-05

Family

ID=59960204

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018070377A BR112018070377A2 (pt) 2016-04-05 2017-04-03 inibidores macrocíclicos das interações de proteína/proteína pd-1/pd-l1 e cd80/pd-l1

Country Status (17)

Country Link
US (1) US10358463B2 (pt)
EP (1) EP3440097A1 (pt)
JP (1) JP7122255B2 (pt)
KR (1) KR102548798B1 (pt)
CN (1) CN109311943A (pt)
AR (1) AR108186A1 (pt)
AU (1) AU2017246216A1 (pt)
BR (1) BR112018070377A2 (pt)
CA (1) CA3020300A1 (pt)
EA (1) EA201892243A1 (pt)
IL (1) IL262126A (pt)
MA (1) MA43774A (pt)
MX (1) MX2018012039A (pt)
SG (1) SG11201808678QA (pt)
TW (1) TW201738260A (pt)
UY (1) UY37194A (pt)
WO (1) WO2017176608A1 (pt)

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