JP5546451B2 - 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト - Google Patents

胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト Download PDF

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JP5546451B2
JP5546451B2 JP2010511309A JP2010511309A JP5546451B2 JP 5546451 B2 JP5546451 B2 JP 5546451B2 JP 2010511309 A JP2010511309 A JP 2010511309A JP 2010511309 A JP2010511309 A JP 2010511309A JP 5546451 B2 JP5546451 B2 JP 5546451B2
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peptide
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cancer
amino acid
composition
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JP2010530849A5 (enExample
JP2010530849A (ja
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カンワー シャイルバイ，
ゲイリー エス． ジャコブ，
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シナジー ファーマシューティカルズ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

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  • Epidemiology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
JP2010511309A 2007-06-04 2008-06-04 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト Active JP5546451B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93319407P 2007-06-04 2007-06-04
US60/933,194 2007-06-04
PCT/US2008/065824 WO2008151257A2 (en) 2007-06-04 2008-06-04 Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders

Related Child Applications (1)

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JP2014099732A Division JP6034329B2 (ja) 2007-06-04 2014-05-13 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト

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JP2010530849A JP2010530849A (ja) 2010-09-16
JP2010530849A5 JP2010530849A5 (enExample) 2012-06-07
JP5546451B2 true JP5546451B2 (ja) 2014-07-09

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JP2010511309A Active JP5546451B2 (ja) 2007-06-04 2008-06-04 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト
JP2014099732A Active JP6034329B2 (ja) 2007-06-04 2014-05-13 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト
JP2016000346A Active JP6412028B2 (ja) 2007-06-04 2016-01-05 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト

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JP2014099732A Active JP6034329B2 (ja) 2007-06-04 2014-05-13 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト
JP2016000346A Active JP6412028B2 (ja) 2007-06-04 2016-01-05 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト

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US (11) US7879802B2 (enExample)
EP (3) EP2527360B1 (enExample)
JP (3) JP5546451B2 (enExample)
CN (2) CN103601792B (enExample)
AU (1) AU2008261102B2 (enExample)
CA (2) CA2688161C (enExample)
DK (1) DK2170930T3 (enExample)
EA (1) EA020466B1 (enExample)
ES (2) ES2393885T7 (enExample)
IL (2) IL202510A (enExample)
MX (3) MX381737B (enExample)
WO (1) WO2008151257A2 (enExample)

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US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
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