ES2130597T3 - Derivados de bifenilo sustituido como inhibidores de la fosfodiesterasa. - Google Patents
Derivados de bifenilo sustituido como inhibidores de la fosfodiesterasa.Info
- Publication number
- ES2130597T3 ES2130597T3 ES95908671T ES95908671T ES2130597T3 ES 2130597 T3 ES2130597 T3 ES 2130597T3 ES 95908671 T ES95908671 T ES 95908671T ES 95908671 T ES95908671 T ES 95908671T ES 2130597 T3 ES2130597 T3 ES 2130597T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- aryl
- conr
- alkyl
- arialkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 title 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 title 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- -1 FURANYL Chemical class 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/235—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/235—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring
- C07C43/247—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
- C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
- C07C65/26—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Abstract
UN COMPUESTO DE ESTRUCTURA (I), EN DONDE, CUANDO R 8 = H:R{SUB,1}= ALQUILO, CICLOALQUILO, ARILALQUILO, ARILO; R{SUB,2}= CICLOALQUILO, ARILO, C{SUB,3}-C{SUB,10} ALQUILO; X, Y=0, S(0){SUB,N}, NH; Z=CH{SUB,2}OH, NHSO{SUB,2}R{SUB,3}, CHO, CO{SUB,2}R{SUB,3}, CONHR{SUB,4}R{SUB,5}, CN, COR{SUB,6},H, HALO,NHCN, NHCONR{SUB,4}R{SUB,5}, CONR{SUB,4}OR{SUB,5}, CONR{SUB,4}NR{SUB,5}R{SUB,6}, 1-TETRAZOL,S(O){SUB,N}OH, S(O){SUB,N}NR{SUB,3}R{SUB,4}, C=NOH, C=N(OH)NH{SUB,2}, OCONR{SUB,7}R{SUB,6}, P(O)(OR{SUB,4}){SUB,2}, NH{SUB,2}, SH, OH, OS(O){SUB,2}R{SUB,3}, C(O)CO{SUB,2}R{SUB,3}, C(O)CONR{SUB,3}R{SUB,4}, CH(OH)CO{SUB,2}R{SUB,3}, CHFCO{SUB,2}R{SUB,3}, CF{SUB,2}CO{SUB,2}R{SUB,3}, CH(OH)CONR{SUB,3}R{SUB,4}, CF{SUB,2}CONR{SUB,3}R{SUB,4}, C=NNH{SUB,2}, C(=NOC(=O)R{SUB,3})R{SUB,4}, C(=NNHC(=O)R{SUB,3})R{SUB,4}, C(=NOH)R{SUB,3}, C(=NNR{SUB,3})R{SUB,4}, NHC(=O)R{SUB,6} O C(O)CONH{SUB,2}; R{SUB,3}, R{SUB,4}, R{SUB,5}, R{SUB,6}, R{SUB,7}= HIDROGENO, ALQUILO, ARILO, ARIALQUILO, CICLOALQUILO O FLUOALQUILO; O UN COMPUESTO DE ESTRUCTURA (I), EN DONDE: R{SUB,1}= ALQUILO, CICLOALQUILO, ARIALQUILO O ARILO; R{SUB,2}= CICLOALQUILO, ARILO O ALQUILO; X, Y= CH{SUB,2},O, S(O){SUB,N} O NH; R{SUB,3}, R{SUB,4}, R{SUB,5}, R{SUB,6}, R{SUB,7} SON CADA UNO , INDEPENDIENTEMENTE, HIDROGENO, ALQUILO, ARILO, ARIALQUILO, CICLOALQUILO O FLUOALQUILO; R{SUB,8}=CO{SUB,2}R{SUB,3}, CONR{SUB,3} O R{SUB,8} Y Z ESTAN CONCATENADOS DE FORMA QUE R{SUB,8}Z=C(O)NHNHC(O), (CH{SUB,2}){SUB,M}C(=W), V(CH{SUB,2}){SUB,M}C(=W) O V{SUB,N}CH=CH(CH{SUB,2}){SUB,N}C(=W); DONDE V=O, S(O){SUB,N}, NH; W=O, NOH, NHNH{SUB,2}, NOC(O)CH{SUB,3} O NNHC(O)CH{SUB,3}, HALO=CL, BR, O I; FLUOALQUILO=CF{SUB,3}CHF{SUB,2}, CH{SUB,2}F, CH{SUB,2}CF{SUB,3}, C{SUB,2}F{SUB,5},CICLOALQUILO=C{SUB,3}-C{SUB,6} CICLOALQUILO, ARIALQUILO=C{SUB,1}-C{SUB,4} ARILO, ARILO=FENILO, FURANILO, TIENILO, O PIRIDILO; N=0-2; Y M=2-4 O SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, UTILES EN EL TRATAMIENTO DE ASMA, O ENFERMEDADES ALERGICAS O INFLAMATORIAS, ASI COMO METODOS PARA EL TRATAMIENTO Y COMPOSICIONES FARMACEUTICAS QUE UTILIZAN LOS MISMOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19803194A | 1994-02-17 | 1994-02-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2130597T3 true ES2130597T3 (es) | 1999-07-01 |
Family
ID=22731725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95908671T Expired - Lifetime ES2130597T3 (es) | 1994-02-17 | 1995-01-25 | Derivados de bifenilo sustituido como inhibidores de la fosfodiesterasa. |
Country Status (19)
Country | Link |
---|---|
US (1) | US5650444A (es) |
EP (1) | EP0745063B1 (es) |
JP (1) | JPH09510191A (es) |
KR (1) | KR970701170A (es) |
AT (1) | ATE178046T1 (es) |
AU (1) | AU692839B2 (es) |
CA (1) | CA2182792A1 (es) |
DE (1) | DE69508568T2 (es) |
DK (1) | DK0745063T3 (es) |
ES (1) | ES2130597T3 (es) |
FI (1) | FI963228A (es) |
GR (1) | GR3030490T3 (es) |
HU (1) | HUT74611A (es) |
IL (1) | IL112538A (es) |
MX (1) | MX9603414A (es) |
NZ (1) | NZ279689A (es) |
SG (1) | SG47624A1 (es) |
TW (1) | TW394757B (es) |
WO (1) | WO1995022520A1 (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0934307B1 (en) | 1996-06-19 | 2011-04-27 | Aventis Pharma Limited | Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase |
EA002113B1 (ru) | 1996-09-04 | 2001-12-24 | Пфайзер Инк. | Производные индазола и их использование в качестве ингибиторов фосфодиэстеразы (фдэ) типа iv и продуцирования фактора некроза опухоли (фно) |
US5981549A (en) * | 1997-02-14 | 1999-11-09 | Synapse Pharmaceutical International | Method for controlling or alleviating the symptoms of respiratory disease and allergies |
EP0934933A1 (en) * | 1998-02-06 | 1999-08-11 | Byk Gulden Lomberg Chemische Fabrik GmbH | Phthalazinones |
ATE320800T1 (de) | 1999-08-21 | 2006-04-15 | Altana Pharma Ag | Synergistische kombination von roflumilast und salmeterol |
IL148361A0 (en) * | 1999-08-31 | 2002-09-12 | Maxia Pharmaceuticals Inc | Benzylidene-thiazolidinedione derivatives and pharmaceutical compositions containing the same |
US6376524B1 (en) * | 2000-06-21 | 2002-04-23 | Sunesis Pharmaceuticals, Inc. | Triphenyl compounds as interleukin-4 antagonists |
PL373912A1 (en) | 2001-03-07 | 2005-09-19 | Incyte San Diego, Inc. | Heterocyclic derivatives for the treatment of cancer and other proliferative diseases |
US7265139B2 (en) * | 2001-03-08 | 2007-09-04 | Incyte San Diego Inc. | RXR activating molecules |
CA2340824A1 (en) * | 2001-03-14 | 2002-09-14 | Ibm Canada Limited-Ibm Canada Limitee | Method and system for application behavior analysis |
JP2005500379A (ja) * | 2001-08-17 | 2005-01-06 | インサイト サンディエゴ インコーポレーテッド | 異脂肪血症および高コレステロール血症を治療するオキシム誘導体 |
WO2003043998A1 (en) * | 2001-11-15 | 2003-05-30 | Incyte San Diego Incorporated | N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders, cancer, and other diseases |
US7102000B2 (en) * | 2002-03-08 | 2006-09-05 | Incyte San Diego Inc. | Heterocyclic amide derivatives for the treatment of diabetes and other diseases |
US7196108B2 (en) * | 2002-03-08 | 2007-03-27 | Incyte San Diego Inc. | Bicyclic heterocycles for the treatment of diabetes and other diseases |
US6706895B1 (en) * | 2002-11-14 | 2004-03-16 | Uniroyal Chemical Company, Inc. | 4-methoxybiphenyl hydrazone derivatives |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
US20050014767A1 (en) * | 2003-01-29 | 2005-01-20 | Magnus Pfahl | Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases |
BRPI0409229A (pt) | 2003-04-01 | 2006-03-28 | Applied Research Systems | inibidores das fosfodiesterases na infertilidade |
CN1774246A (zh) * | 2003-04-18 | 2006-05-17 | 因齐特圣迭戈公司 | 用于治疗代谢失调、癌症和其它疾病的取代异色满化合物 |
US7279600B2 (en) * | 2003-05-02 | 2007-10-09 | Wyeth | Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents |
JP2009501721A (ja) * | 2005-07-12 | 2009-01-22 | アカディア ファーマシューティカルズ インコーポレイテッド | レチノイン酸受容体における活性を伴う化合物 |
PE20070182A1 (es) | 2005-07-29 | 2007-03-06 | Wyeth Corp | Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona |
WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
WO2009149279A2 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
EP2563770B1 (en) | 2010-04-28 | 2016-03-23 | Leo Pharma A/S | Biaryl phosphodiesterase inhibitors |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
EP3366698A1 (en) | 2011-03-01 | 2018-08-29 | Synergy Pharmaceuticals Inc. | Guanylate cyclase c agonists |
CA2902348C (en) | 2013-02-25 | 2021-11-30 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
EP2968439A2 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
CA2913737A1 (en) | 2013-06-05 | 2014-12-11 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
CN105979959B (zh) | 2013-08-09 | 2021-11-30 | 阿德利克斯公司 | 用于抑制磷酸盐转运的化合物和方法 |
WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2716663A (en) * | 1953-07-09 | 1955-08-30 | Dow Chemical Co | Hydrazides of phenyl substituted dihydroxybenzoic acids |
US2759964A (en) * | 1953-07-09 | 1956-08-21 | Dow Chemical Co | Dialkylaminoalkyl esters of phenyl substituted dihydroxybenzoic acids |
US2921939A (en) * | 1955-11-28 | 1960-01-19 | Metal & Thermit Corp | Process for preparing alpha-substituted acetic acids |
US3043746A (en) * | 1959-11-02 | 1962-07-10 | Vismara Francesco Spa | 2-(4-biphenylyl)-delta-hexenoic acid and derivatives as anticholesterinemic agents |
US3120551A (en) * | 1961-03-20 | 1964-02-04 | Warner Lambert Pharmaceutical | 5-(4-biphenylyl)-3-methylvaleric acid and functional derivatives thereof |
US3624142A (en) * | 1964-09-10 | 1971-11-30 | Merck & Co Inc | Substituted biphenyl acetic acid derivatives |
US3457300A (en) * | 1965-06-11 | 1969-07-22 | Merck & Co Inc | Acetic acid type compounds |
US3681445A (en) * | 1968-01-19 | 1972-08-01 | Merck & Co Inc | Substituted phenyl benzoic acid compounds |
US3671580A (en) * | 1969-12-22 | 1972-06-20 | Merck & Co Inc | Substituted biphenyl acetic acids and ester derivatives thereof |
GB1433130A (en) * | 1972-11-09 | 1976-04-22 | Secr Defence | Substituted biphenyl and polyphenyl compounds and liquid crystal materials and devices containing them |
GB1459084A (en) * | 1973-05-24 | 1976-12-22 | Boots Co Ltd | Preparation of arylalkanoic acid |
JPS5387340A (en) * | 1977-01-10 | 1978-08-01 | Seiko Epson Corp | Method of synthesis |
US4916145A (en) * | 1987-07-10 | 1990-04-10 | Hoffmann-La Roche Inc. | Substituted n-[(pyridyl)alkyl]aryl-carboxamide |
DE3903989A1 (de) * | 1989-02-10 | 1990-09-20 | Basf Ag | Diphenylheteroalkylderivate, ihre herstellung und daraus hergestellte arzneimittel und kosmetika |
DE3903988A1 (de) * | 1989-02-10 | 1990-08-30 | Basf Ag | Oxidierte diphenylheteroalkane, ihre herstellung und verwendung |
GB9007762D0 (en) * | 1990-04-05 | 1990-06-06 | Beecham Group Plc | Novel compounds |
CA2044533A1 (en) * | 1990-06-29 | 1991-12-30 | Philippe Guerry | Substituted aminoalkylbiphenyl derivatives |
JPH06501941A (ja) * | 1990-10-16 | 1994-03-03 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | アリールピリダジノン |
WO1993007111A1 (en) * | 1991-10-02 | 1993-04-15 | Smithkline Beecham Corporation | Cyclopentane and cyclopentene derivatives with antiallergic antiinflammatory and tumor necrosis factor inhibiting activity |
GB9222253D0 (en) * | 1992-10-23 | 1992-12-09 | Celltech Ltd | Chemical compounds |
KR950704228A (ko) * | 1992-12-02 | 1995-11-17 | 알렌 제이. 스피겔 | 선택적 포스포디에스테르가수분해효소 iv형(pde_iv) 저해제로서의 카테콜 디에테르(catecol diethers as selective pde_iv inhibitors) |
-
1995
- 1995-01-25 CA CA002182792A patent/CA2182792A1/en not_active Abandoned
- 1995-01-25 AT AT95908671T patent/ATE178046T1/de not_active IP Right Cessation
- 1995-01-25 ES ES95908671T patent/ES2130597T3/es not_active Expired - Lifetime
- 1995-01-25 JP JP7521806A patent/JPH09510191A/ja active Pending
- 1995-01-25 WO PCT/US1995/000996 patent/WO1995022520A1/en active IP Right Grant
- 1995-01-25 DK DK95908671T patent/DK0745063T3/da active
- 1995-01-25 AU AU16905/95A patent/AU692839B2/en not_active Ceased
- 1995-01-25 MX MX9603414A patent/MX9603414A/es unknown
- 1995-01-25 NZ NZ279689A patent/NZ279689A/xx unknown
- 1995-01-25 DE DE69508568T patent/DE69508568T2/de not_active Expired - Fee Related
- 1995-01-25 HU HU9602267A patent/HUT74611A/hu unknown
- 1995-01-25 EP EP95908671A patent/EP0745063B1/en not_active Expired - Lifetime
- 1995-02-03 IL IL11253895A patent/IL112538A/xx not_active IP Right Cessation
- 1995-02-07 TW TW084100953A patent/TW394757B/zh active
- 1995-05-25 US US08/452,593 patent/US5650444A/en not_active Expired - Lifetime
- 1995-06-25 SG SG1996003239A patent/SG47624A1/en unknown
-
1996
- 1996-08-16 FI FI963228A patent/FI963228A/fi unknown
- 1996-08-16 KR KR1019960704462A patent/KR970701170A/ko not_active Application Discontinuation
-
1999
- 1999-06-10 GR GR990401565T patent/GR3030490T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69508568T2 (de) | 1999-10-21 |
EP0745063A1 (en) | 1996-12-04 |
DE69508568D1 (de) | 1999-04-29 |
NZ279689A (en) | 1997-08-22 |
JPH09510191A (ja) | 1997-10-14 |
AU692839B2 (en) | 1998-06-18 |
US5650444A (en) | 1997-07-22 |
MX9603414A (es) | 1997-03-29 |
TW394757B (en) | 2000-06-21 |
IL112538A (en) | 1999-09-22 |
IL112538A0 (en) | 1995-05-26 |
CA2182792A1 (en) | 1995-08-24 |
SG47624A1 (en) | 1998-04-17 |
EP0745063B1 (en) | 1999-03-24 |
ATE178046T1 (de) | 1999-04-15 |
FI963228A0 (fi) | 1996-08-16 |
HUT74611A (en) | 1997-01-28 |
GR3030490T3 (en) | 1999-10-29 |
WO1995022520A1 (en) | 1995-08-24 |
AU1690595A (en) | 1995-09-04 |
DK0745063T3 (da) | 1999-10-11 |
HU9602267D0 (en) | 1996-10-28 |
KR970701170A (ko) | 1997-03-17 |
FI963228A (fi) | 1996-08-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2130597T3 (es) | Derivados de bifenilo sustituido como inhibidores de la fosfodiesterasa. | |
FI953497A0 (fi) | Spirosykloalkyylisubstituoidut atsetidinonit, jotka ovat käyttökelpoisia hypokolesteroleemisina aineina | |
TW200510327A (en) | 4-cyanopyrazole-3-carboxamide derivatives, their preparation, their therapeutic application | |
IL106099A0 (en) | Pyrazole derivatives,their preparation and pharmaceutical compositions containing them | |
FI953748A0 (fi) | Yhdisteitä, joilla on sekä voimakas kalsium antagonisti- että antioksidanttiaktiivisuus sekä niiden käyttö solua suojaavina aineina | |
EA200100135A1 (ru) | Алкинилзамещенные производные хинолин-2-она, полезные в качестве противораковых агентов | |
NO20050666L (no) | 2,7-substituerte indoler og deres anvendelse som 5-HT6 modulatorer | |
MX9801129A (es) | Agentes farmaceuticos. | |
HUP0000343A2 (hu) | 1,3-Propándiol-származékok alkalmazása szervátültetés után fellépő kilökődés megakadályozására | |
EA199900421A1 (ru) | Бензонафтиридины в качестве бронхиальных терапевтических средств | |
WO2005030766A8 (en) | Phenyl - carboxamide compounds useful for treating pain | |
ATE180781T1 (de) | Kristallines tiagabinehydrochlorid-monohydrat, seine herstellung und verwendung | |
AR007108A1 (es) | Agentes antitumorales y antivirales alquilantes, procedimiento para su preparacion, utilizacion de los mismos para la fabricacion de un medicamento y composicion farmaceutica que contiene a dichos agentes. | |
ATE70056T1 (de) | Oxopyrimidin-derivate und sie enthaltende pharmazeutische zubereitungen. | |
BG104933A (en) | Water soluble azoles and broad-spectrum antifungals | |
GB0302220D0 (en) | Use | |
NO20010654D0 (no) | Ny anvendelse av taxoidderivater | |
AR007052A1 (es) | Un derivado de carbohidrato, su uso y una composicion farmaceutica que lo comprende | |
RU94011565A (ru) | Тиоксантеноновые соединения, их использование, противоопухолевая композиция | |
DE60002143D1 (de) | Behandlung autoimmunerkrankungen in säugern | |
GEP20074180B (en) | Substituted benzol[e] [1,4] oxazino[3,2-g] isoindole derivatives, method for preparing same and pharmaceutical compositions containing same | |
RS20050958A (en) | Fungicidal mixtures | |
EA200600831A1 (ru) | Фунгицидные смеси, в частности, для борьбы с патогенами риса | |
MX9701529A (es) | Uso de (e)-1-[4'-(2-alquilaminoetoxi)fenil]-1-(3'-hidroxifenil)-2-f enilbut-1-enos para inhibir trastornos patologicos. | |
TH11122EX (th) | การใช้แอเซแลสทีนเป็นสารแสดงฤทธิ์ในการต่อต้านความผิดปกติเกี่ยวกับโรคเรื้อนกวาง และความผิดปกติเกี่ยวกับการอักเสบ |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 745063 Country of ref document: ES |