MX9801129A - Agentes farmaceuticos. - Google Patents
Agentes farmaceuticos.Info
- Publication number
- MX9801129A MX9801129A MX9801129A MX9801129A MX9801129A MX 9801129 A MX9801129 A MX 9801129A MX 9801129 A MX9801129 A MX 9801129A MX 9801129 A MX9801129 A MX 9801129A MX 9801129 A MX9801129 A MX 9801129A
- Authority
- MX
- Mexico
- Prior art keywords
- hydrogen
- pharmaceutical agents
- formula
- inhibitin
- cycloalky
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion proporciona un procedimiento para inhibir el deterioro del metabolismo de la glucosa en un mamífero administrado una aminopirimidina sustituida que tiene la formula (Ver Formula) en laque R1, R2 y R3 son, independientemente, hidrogeno, halogeno, alcoxi C1-C4, (alquilo C1-C4)tio, alquilo C1-C4 o cicloalquilo C1-C3; R4 es hidrogeno, formilo, acetilo, propionilo o butirilo, a condicion de que R1,R4 no sean todos hidrogeno al mismo tiempo; o una sal o solvato farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79866197A | 1997-02-11 | 1997-02-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9801129A true MX9801129A (es) | 1998-11-29 |
Family
ID=25173964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9801129A MX9801129A (es) | 1997-02-11 | 1998-02-10 | Agentes farmaceuticos. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0857483A1 (es) |
JP (1) | JPH10218773A (es) |
KR (1) | KR19980071226A (es) |
AU (1) | AU5387898A (es) |
CA (1) | CA2229123A1 (es) |
CZ (1) | CZ39398A3 (es) |
HU (1) | HUP9800291A2 (es) |
IL (1) | IL123232A0 (es) |
MX (1) | MX9801129A (es) |
NO (1) | NO980546L (es) |
SG (1) | SG76535A1 (es) |
ZA (1) | ZA981029B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2727400A (en) * | 1999-01-29 | 2000-08-18 | Eli Lilly And Company | Moxonidine salts |
ITTV20010002U1 (it) | 2001-01-12 | 2002-07-12 | Vetraria Biancadese Sas Soc | Tavolo avente almeno una prolunga estraibile mediante semplice rotazione |
PL377847A1 (pl) | 2003-01-14 | 2006-02-20 | Arena Pharmaceuticals Inc. | 1,2,3-Tripodstawione pochodne arylowe i heteroarylowe jako modulatory metabolizmu oraz profilaktyka i leczenie związanych z nim zaburzeń takich jak cukrzyca i hiperglikemia |
EP1606282B1 (en) * | 2003-02-24 | 2008-11-12 | Arena Pharmaceuticals, Inc. | Phenyl- and pyridylpipereidinye-derivatives as modulators of glucose metabolism |
AR045047A1 (es) | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
BRPI0415198A (pt) * | 2003-10-10 | 2006-12-05 | Solvay Pharm Gmbh | composição farmacêutica compreendendo um agonista seletivo do receptor da imidazolina i1 e um bloqueador do receptor da angiotensina ii |
DOP2006000010A (es) | 2005-01-10 | 2006-07-31 | Arena Pharm Inc | Procedimiento para preparar eteres aromáticos |
MY148521A (en) | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
EP1981498A2 (en) * | 2006-01-27 | 2008-10-22 | F. Hoffmann-la Roche AG | Use of 2-imidazoles for the treatment of cns disorders |
ES2381589T3 (es) | 2006-10-19 | 2012-05-29 | F. Hoffmann-La Roche Ag | Aminometil-4-imidazoles |
WO2008052907A1 (en) | 2006-11-02 | 2008-05-08 | F. Hoffmann-La Roche Ag | Substituted 2-imidazoles as modulators of the trace amine associated receptors |
RU2456281C2 (ru) | 2006-11-16 | 2012-07-20 | Ф. Хоффманн-Ля Рош Аг | Замещенные 4-имидазолы, способ их получения и их применение |
AU2007332641A1 (en) | 2006-12-13 | 2008-06-19 | F. Hoffmann-La Roche Ag | Novel 2 -imidazoles as ligands for trace amine associated receptors (TAAR) |
US20080146523A1 (en) | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
RU2473545C2 (ru) | 2007-02-02 | 2013-01-27 | Ф.Хоффманн-Ля Рош Аг | Новые 2-аминооксазолины в качестве лигандов taar1 для заболеваний цнс |
RU2460725C2 (ru) | 2007-02-15 | 2012-09-10 | Ф. Хоффманн-Ля Рош Аг | Новые 2-аминооксазолины в качестве лигандов taar1 |
MX2009013742A (es) | 2007-07-02 | 2010-01-26 | Hoffmann La Roche | 2-imidazolinas. |
AU2008270444A1 (en) | 2007-07-03 | 2009-01-08 | F. Hoffmann-La Roche Ag | 4-imidazolines and their use as antidepressants |
RU2010104632A (ru) | 2007-07-27 | 2011-09-20 | Ф.Хоффманн-Ля Рош Аг (Ch) | 2-азетидинметанамины и 2-пирролидинметанамины в качестве лигандов taar |
JP5341084B2 (ja) | 2007-08-03 | 2013-11-13 | エフ.ホフマン−ラ ロシュ アーゲー | Taar1リガンドとしてのピリジンカルボキシアミド及びベンズアミド誘導体 |
US8242153B2 (en) | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
US8354441B2 (en) | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
BR112013008100A2 (pt) | 2010-09-22 | 2016-08-09 | Arena Pharm Inc | "moduladores do receptor de gpr19 e o tratamento de distúrbios relacionados a eles." |
EP2829540A1 (en) | 2013-07-26 | 2015-01-28 | Abbott Healthcare Products B.V. | Synthesis of substituted aminopyridines |
AU2016205361C1 (en) | 2015-01-06 | 2021-04-08 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
SI3310760T1 (sl) | 2015-06-22 | 2023-02-28 | Arena Pharmaceuticals, Inc. | Kristalinična L-argininska sol (R)-2-(7-(4-ciklopentil-3-(trifluorometil)benziloksi)-1,2,3,4- tetrahidrociklo-penta(b)indol-3-il)ocetne kisline za uporabo pri motnjah, povezanih z receptorjem S1P1 |
RU2731095C2 (ru) | 2016-03-17 | 2020-08-28 | Ф. Хоффманн-Ля Рош Аг | Производное 5-этил-4-метил-пиразол-3-карбоксамида, обладающее активностью агониста taar |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4323570A (en) * | 1978-11-15 | 1982-04-06 | Beiersdorf Aktiengesellschaft | Substituted aminopyrimidines |
DE4423177A1 (de) * | 1994-07-01 | 1996-01-04 | Kali Chemie Pharma Gmbh | Antihyperglykämisch wirksame Arzneimittel |
-
1998
- 1998-02-09 NO NO980546A patent/NO980546L/no unknown
- 1998-02-09 IL IL12323298A patent/IL123232A0/xx unknown
- 1998-02-09 CA CA002229123A patent/CA2229123A1/en not_active Abandoned
- 1998-02-09 ZA ZA9801029A patent/ZA981029B/xx unknown
- 1998-02-10 JP JP10028170A patent/JPH10218773A/ja not_active Withdrawn
- 1998-02-10 SG SG1998000280A patent/SG76535A1/en unknown
- 1998-02-10 EP EP98300968A patent/EP0857483A1/en not_active Withdrawn
- 1998-02-10 CZ CZ98393A patent/CZ39398A3/cs unknown
- 1998-02-10 MX MX9801129A patent/MX9801129A/es unknown
- 1998-02-10 KR KR1019980003819A patent/KR19980071226A/ko not_active Application Discontinuation
- 1998-02-11 AU AU53878/98A patent/AU5387898A/en not_active Abandoned
- 1998-02-11 HU HU9800291A patent/HUP9800291A2/hu unknown
Also Published As
Publication number | Publication date |
---|---|
JPH10218773A (ja) | 1998-08-18 |
KR19980071226A (ko) | 1998-10-26 |
AU5387898A (en) | 1998-08-13 |
IL123232A0 (en) | 1999-11-30 |
HU9800291D0 (en) | 1998-04-28 |
EP0857483A1 (en) | 1998-08-12 |
CA2229123A1 (en) | 1998-08-11 |
NO980546L (no) | 1998-08-12 |
HUP9800291A2 (hu) | 2001-02-28 |
NO980546D0 (no) | 1998-02-09 |
CZ39398A3 (cs) | 1998-08-12 |
SG76535A1 (en) | 2000-11-21 |
ZA981029B (en) | 1999-08-10 |
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