MX9801129A - Agentes farmaceuticos. - Google Patents
Agentes farmaceuticos.Info
- Publication number
- MX9801129A MX9801129A MX9801129A MX9801129A MX9801129A MX 9801129 A MX9801129 A MX 9801129A MX 9801129 A MX9801129 A MX 9801129A MX 9801129 A MX9801129 A MX 9801129A MX 9801129 A MX9801129 A MX 9801129A
- Authority
- MX
- Mexico
- Prior art keywords
- hydrogen
- pharmaceutical agents
- formula
- inhibitin
- cycloalky
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion proporciona un procedimiento para inhibir el deterioro del metabolismo de la glucosa en un mamífero administrado una aminopirimidina sustituida que tiene la formula (Ver Formula) en laque R1, R2 y R3 son, independientemente, hidrogeno, halogeno, alcoxi C1-C4, (alquilo C1-C4)tio, alquilo C1-C4 o cicloalquilo C1-C3; R4 es hidrogeno, formilo, acetilo, propionilo o butirilo, a condicion de que R1,R4 no sean todos hidrogeno al mismo tiempo; o una sal o solvato farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79866197A | 1997-02-11 | 1997-02-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9801129A true MX9801129A (es) | 1998-11-29 |
Family
ID=25173964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9801129A MX9801129A (es) | 1997-02-11 | 1998-02-10 | Agentes farmaceuticos. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0857483A1 (es) |
JP (1) | JPH10218773A (es) |
KR (1) | KR19980071226A (es) |
AU (1) | AU5387898A (es) |
CA (1) | CA2229123A1 (es) |
CZ (1) | CZ39398A3 (es) |
HU (1) | HUP9800291A2 (es) |
IL (1) | IL123232A0 (es) |
MX (1) | MX9801129A (es) |
NO (1) | NO980546L (es) |
SG (1) | SG76535A1 (es) |
ZA (1) | ZA981029B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2727400A (en) * | 1999-01-29 | 2000-08-18 | Eli Lilly And Company | Moxonidine salts |
ITTV20010002U1 (it) | 2001-01-12 | 2002-07-12 | Vetraria Biancadese Sas Soc | Tavolo avente almeno una prolunga estraibile mediante semplice rotazione |
GEP20084540B (en) | 2003-01-14 | 2008-11-25 | Arena Pharm Inc | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
CN1751038A (zh) * | 2003-02-24 | 2006-03-22 | 艾尼纳制药公司 | 作为葡萄糖代谢调节剂的经取代芳基和杂芳基衍生物及葡萄糖代谢失调的预防和治疗 |
AR045047A1 (es) | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
KR101137084B1 (ko) * | 2003-10-10 | 2012-04-24 | 애보트 프러덕츠 게엠베하 | 셀렉티브 ⅰ1 이미다졸린 수용체 작용제 및 엔지오텐신 ⅱ수용체 차단제를 포함하는 약학적 조성물 |
DOP2006000010A (es) | 2005-01-10 | 2006-07-31 | Arena Pharm Inc | Procedimiento para preparar eteres aromáticos |
MY148521A (en) | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
AU2007213887A1 (en) * | 2006-01-27 | 2007-08-16 | F. Hoffmann-La Roche Ag | Use of 2-imidazoles for the treatment of CNS disorders |
KR101176699B1 (ko) | 2006-10-19 | 2012-08-23 | 에프. 호프만-라 로슈 아게 | 아미노메틸-4-이미다졸 |
ATE533755T1 (de) | 2006-11-02 | 2011-12-15 | Hoffmann La Roche | Substituierte 2-imidazole als modulatoren der mit spurenaminen assoziierten rezeptoren |
RU2456281C2 (ru) | 2006-11-16 | 2012-07-20 | Ф. Хоффманн-Ля Рош Аг | Замещенные 4-имидазолы, способ их получения и их применение |
BRPI0720047A2 (pt) | 2006-12-13 | 2013-12-24 | Hoffmann La Roche | 2-imidazóis como ligantes para receptores associados a aminas de traço (taar) |
US20080146523A1 (en) | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
CA2675221C (en) | 2007-02-02 | 2016-02-23 | F. Hoffmann-La Roche Ag | Novel 2-aminooxazolines as taar1 ligands |
KR101222412B1 (ko) | 2007-02-15 | 2013-01-15 | 에프. 호프만-라 로슈 아게 | Taar1 리간드로서의 2-아미노옥사졸린 |
WO2009003868A2 (en) | 2007-07-02 | 2009-01-08 | F. Hoffmann-La Roche Ag | 2 -imidazolines having a good affinity to the trace amine associated receptors (taars) |
CA2691704A1 (en) | 2007-07-03 | 2009-01-08 | F. Hoffmann-La Roche Ag | 4-imidazolines and their use as antidepressants |
BRPI0813837A2 (pt) | 2007-07-27 | 2015-01-06 | Hoffmann La Roche | 2-azetidinametanoaminas e 2-pirrolidinametanoaminas como ligantes de taar |
JP5341084B2 (ja) | 2007-08-03 | 2013-11-13 | エフ.ホフマン−ラ ロシュ アーゲー | Taar1リガンドとしてのピリジンカルボキシアミド及びベンズアミド誘導体 |
US8242153B2 (en) | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
US8354441B2 (en) | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
CA2812061A1 (en) | 2010-09-22 | 2012-03-29 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
EP2829540A1 (en) | 2013-07-26 | 2015-01-28 | Abbott Healthcare Products B.V. | Synthesis of substituted aminopyridines |
AU2016205361C1 (en) | 2015-01-06 | 2021-04-08 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
KR102603199B1 (ko) | 2015-06-22 | 2023-11-16 | 아레나 파마슈티칼스, 인크. | S1p1 수용체-관련 장애에서의 사용을 위한 (r)-2-(7-(4-시클로펜틸-3-(트리플루오로메틸)벤질옥시)-1,2,3,4-테트라히드로시클로-펜타[b]인돌-3-일)아세트산 (화합물 1)의 결정성 l-아르기닌 염 |
AU2017234042B2 (en) | 2016-03-17 | 2020-11-19 | F. Hoffmann-La Roche Ag | 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of TAAR |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4323570A (en) * | 1978-11-15 | 1982-04-06 | Beiersdorf Aktiengesellschaft | Substituted aminopyrimidines |
DE4423177A1 (de) * | 1994-07-01 | 1996-01-04 | Kali Chemie Pharma Gmbh | Antihyperglykämisch wirksame Arzneimittel |
-
1998
- 1998-02-09 IL IL12323298A patent/IL123232A0/xx unknown
- 1998-02-09 CA CA002229123A patent/CA2229123A1/en not_active Abandoned
- 1998-02-09 ZA ZA9801029A patent/ZA981029B/xx unknown
- 1998-02-09 NO NO980546A patent/NO980546L/no unknown
- 1998-02-10 EP EP98300968A patent/EP0857483A1/en not_active Withdrawn
- 1998-02-10 MX MX9801129A patent/MX9801129A/es unknown
- 1998-02-10 JP JP10028170A patent/JPH10218773A/ja not_active Withdrawn
- 1998-02-10 CZ CZ98393A patent/CZ39398A3/cs unknown
- 1998-02-10 SG SG1998000280A patent/SG76535A1/en unknown
- 1998-02-10 KR KR1019980003819A patent/KR19980071226A/ko not_active Application Discontinuation
- 1998-02-11 HU HU9800291A patent/HUP9800291A2/hu unknown
- 1998-02-11 AU AU53878/98A patent/AU5387898A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CZ39398A3 (cs) | 1998-08-12 |
IL123232A0 (en) | 1999-11-30 |
JPH10218773A (ja) | 1998-08-18 |
KR19980071226A (ko) | 1998-10-26 |
ZA981029B (en) | 1999-08-10 |
HUP9800291A2 (hu) | 2001-02-28 |
CA2229123A1 (en) | 1998-08-11 |
NO980546D0 (no) | 1998-02-09 |
AU5387898A (en) | 1998-08-13 |
HU9800291D0 (en) | 1998-04-28 |
EP0857483A1 (en) | 1998-08-12 |
NO980546L (no) | 1998-08-12 |
SG76535A1 (en) | 2000-11-21 |
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