ATE226090T1 - Kolon-spezifisches arzneistofffreisetzungssystem - Google Patents

Kolon-spezifisches arzneistofffreisetzungssystem

Info

Publication number
ATE226090T1
ATE226090T1 AT95916009T AT95916009T ATE226090T1 AT E226090 T1 ATE226090 T1 AT E226090T1 AT 95916009 T AT95916009 T AT 95916009T AT 95916009 T AT95916009 T AT 95916009T AT E226090 T1 ATE226090 T1 AT E226090T1
Authority
AT
Austria
Prior art keywords
colon
release system
drug release
drug
specific drug
Prior art date
Application number
AT95916009T
Other languages
English (en)
Inventor
Shunsuke Watanabe
Hitoshi Kawai
Masataka Katsuma
Muneo Fukui
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Application granted granted Critical
Publication of ATE226090T1 publication Critical patent/ATE226090T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
AT95916009T 1994-04-22 1995-04-19 Kolon-spezifisches arzneistofffreisetzungssystem ATE226090T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8511494 1994-04-22
PCT/JP1995/000766 WO1995028963A1 (fr) 1994-04-22 1995-04-19 Systeme de liberation de medicament specifique au colon

Publications (1)

Publication Number Publication Date
ATE226090T1 true ATE226090T1 (de) 2002-11-15

Family

ID=13849609

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02077556T ATE357221T1 (de) 1994-04-22 1995-04-19 Kolon-spezifisches arzneistofffreisetzungssystem
AT95916009T ATE226090T1 (de) 1994-04-22 1995-04-19 Kolon-spezifisches arzneistofffreisetzungssystem

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT02077556T ATE357221T1 (de) 1994-04-22 1995-04-19 Kolon-spezifisches arzneistofffreisetzungssystem

Country Status (12)

Country Link
US (2) US6368629B1 (de)
EP (2) EP1252896B1 (de)
JP (1) JP3867171B2 (de)
KR (1) KR100388569B1 (de)
CN (1) CN1072964C (de)
AT (2) ATE357221T1 (de)
AU (1) AU689250B2 (de)
DE (2) DE69535432T2 (de)
ES (2) ES2188657T3 (de)
RU (1) RU2155605C2 (de)
TW (1) TW422701B (de)
WO (1) WO1995028963A1 (de)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69535432T2 (de) * 1994-04-22 2007-12-06 Astellas Pharma Inc. Kolon-spezifisches Arzneistofffreisetzungssystem
US5912014A (en) * 1996-03-15 1999-06-15 Unigene Laboratories, Inc. Oral salmon calcitonin pharmaceutical products
US5814308A (en) * 1996-03-26 1998-09-29 Zhang; Ke Methods for the treatment of gastrointestinal tract disorders
US5948892A (en) * 1996-12-16 1999-09-07 Amgen Inc. Analogs of macrophage stimulating protein
WO1998026767A2 (en) * 1996-12-17 1998-06-25 Poli Industria Chimica S.P.A. Site-specific controlled release dosage formulation for mesalamine
JP3819441B2 (ja) * 1997-01-09 2006-09-06 森永乳業株式会社 ラクトフェリン錠剤
DE19732903A1 (de) 1997-07-30 1999-02-04 Falk Pharma Gmbh Pellet-Formulierung zur Behandlung des Intestinaltraktes
US6099859A (en) * 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
EP1074250B1 (de) * 1998-04-30 2004-03-24 Morinaga Milk Industry Co., Ltd. Zuckerbeschichtete tabletten
CA2358296A1 (en) * 1999-01-05 2000-07-13 Anthony P. Adamis Targeted transscleral controlled release drug delivery to the retina and choroid
US6355270B1 (en) * 1999-01-11 2002-03-12 The Regents Of The University Of California Particles for oral delivery of peptides and proteins
IT1312569B1 (it) * 1999-05-21 2002-04-22 Raffaele Ansovini Uso dell'enzima gssg reduttasi per il trattamento terapeutico e laprofilassi di pazienti infettati da hiv.
EP1184038B1 (de) 1999-06-09 2005-12-28 Mochida Pharmaceutical Co., Ltd. System für wirkstofffreisetzung im unteren verdauungstrakt
TR200200562T2 (tr) 1999-06-14 2002-05-21 Cosmo S.P.A Vücutta kontrollü şekilde salgılanabilen ve nahoş tadı önleyebilen ağızdan alınmaya mahsus farmasötik bileşimler
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
EP1197228A4 (de) 1999-07-02 2004-03-10 Hisamitsu Pharmaceutical Co Arzneimittel für die behandlung von kolorektalem krebs
EP1203590B1 (de) 1999-08-09 2007-07-04 Dainippon Sumitomo Pharma Co., Ltd. Chitosanpulver enthaltende feste zubereitungen und verfahren zu deren herstellung
JP4524009B2 (ja) * 1999-08-09 2010-08-11 大日本住友製薬株式会社 大腸内放出性カプセル製剤
US8178150B2 (en) 2000-02-22 2012-05-15 Suzanne Jaffe Stillman Water containing soluble fiber
US7892586B2 (en) 2001-02-22 2011-02-22 Suzanne Jaffe Stillman Water containing soluble fiber
JP5178982B2 (ja) * 2000-05-18 2013-04-10 セリックス， インコーポレイテッド 経口投薬形態における、毒性コアの非毒性領域中へのカプセル化
US7842308B2 (en) 2001-01-30 2010-11-30 Smithkline Beecham Limited Pharmaceutical formulation
US20050175687A1 (en) * 2001-01-30 2005-08-11 Mcallister Stephen M. Pharmaceutical formulations
US7883721B2 (en) 2001-01-30 2011-02-08 Smithkline Beecham Limited Pharmaceutical formulation
GB0102342D0 (en) * 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
US7316819B2 (en) * 2001-03-08 2008-01-08 Unigene Laboratories, Inc. Oral peptide pharmaceutical dosage form and method of production
WO2002085415A1 (en) * 2001-04-17 2002-10-31 Biomatrix, Inc Non-digestible sugar-coated products and process
DE60230632D1 (de) 2001-07-18 2009-02-12 Euro Celtique Sa Pharmazeutische kombinationen von oxycodon und naloxon
US20030044458A1 (en) * 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
AU2011205217B2 (en) * 2001-08-06 2013-06-13 Euro-Celtique S.A. Oral dosage form comprising a therapeutic agent and an adverse-effect agent
US7196059B2 (en) * 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
JP2003201256A (ja) * 2001-12-28 2003-07-18 Hisamitsu Pharmaceut Co Inc 大腸送達性経口医薬製剤、大腸癌治療用経口医薬製剤および大腸炎治療用経口医薬製剤
EP1466626A4 (de) * 2002-01-16 2007-09-05 Astellas Pharma Inc Medizinische zusammensetzungen zur verbesserten oralen aufnahme
AU2003217531A1 (en) * 2002-05-02 2003-11-17 Massachusetts Eye And Ear Infirmary Ocular drug delivery systems and use thereof
JP2004075582A (ja) * 2002-08-13 2004-03-11 Takeda Chem Ind Ltd 固形医薬組成物に処方される有効成分以外の成分の安定化方法
WO2004019907A1 (en) * 2002-08-29 2004-03-11 Activbiotics, Inc. Methods and reagents for treating infections of clostridium difficile and diseases associated therewith
DE10260921A1 (de) * 2002-12-20 2004-07-01 Röhm GmbH & Co. KG Verfahren zum Überziehen von Substraten für pharmazeutische Anwendungen mit einem Gemisch aus zwei filmbildenden Überzugsmitteln
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
WO2004073551A2 (en) * 2003-02-18 2004-09-02 Massachusetts Eye And Ear Infirmary Transscleral drug delivery device and related methods
GB0310919D0 (en) * 2003-05-13 2003-06-18 West Pharm Serv Drug Res Ltd Pharmaceutical compositions
US20050142191A1 (en) * 2003-06-23 2005-06-30 Neurochem (International) Limited Pharmaceutical formulations of amyloid inhibiting compounds
US20060079578A1 (en) * 2003-06-23 2006-04-13 Julie Laurin Pharmaceutical formulations of amyloid inhibiting compounds
TW200526274A (en) 2003-07-21 2005-08-16 Smithkline Beecham Plc Pharmaceutical formulations
US7737133B2 (en) 2003-09-03 2010-06-15 Agi Therapeutics Ltd. Formulations and methods of treating inflammatory bowel disease
US7825106B2 (en) 2003-09-03 2010-11-02 Agi Therapeutics Ltd. Modified release formulations and methods of treating inflammatory bowel disease
US20050123596A1 (en) * 2003-09-23 2005-06-09 Kohane Daniel S. pH-triggered microparticles
US7943179B2 (en) * 2003-09-23 2011-05-17 Massachusetts Institute Of Technology pH triggerable polymeric particles
WO2005048998A1 (en) * 2003-11-21 2005-06-02 Commonwealth Scientific & Industrial Research Organisation G i tract delivery systems
US7670624B2 (en) 2004-01-29 2010-03-02 Astella Pharma Inc. Gastrointestinal-specific multiple drug release system
TW200539903A (en) 2004-03-12 2005-12-16 Smithkline Beecham Plc Pharmaceutical formulations
KR20070006907A (ko) * 2004-04-28 2007-01-11 커먼웰쓰 사이언티픽 앤드 인더스트리얼 리서치 오가니제이션 전분 처리 가공
US20080286359A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
US20080287400A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
US7645459B2 (en) 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
US7645460B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of risedronate
RU2284832C2 (ru) * 2004-08-30 2006-10-10 Николай Александрович Киселев Антимикробная композиция для перорального введения
CN101193628A (zh) * 2005-04-12 2008-06-04 神经化学（国际）有限公司 淀粉样蛋白抑制性化合物的药物制剂
US20060280795A1 (en) * 2005-06-08 2006-12-14 Dexcel Pharma Technologies, Ltd. Specific time-delayed burst profile delivery system
US20080318910A1 (en) * 2005-10-04 2008-12-25 Mistral Pharma, Inc. Controlled-Release Oral Dosage Form
GB0607534D0 (en) * 2006-04-13 2006-05-24 Univ London Pharmacy Colonic drug delivery formulation
WO2008093554A1 (ja) * 2007-01-30 2008-08-07 Olympus Medical Systems Corp. 管腔通過確認装置および管腔通過確認装置の製造方法
CA2683415C (en) 2007-04-04 2020-12-08 Sigmoid Pharma Limited An oral pharmaceutical composition
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2688161C (en) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US20090036414A1 (en) * 2007-08-02 2009-02-05 Mutual Pharmaceutical Company, Inc. Mesalamine Formulations
DE102007060175A1 (de) * 2007-12-13 2009-06-18 Johannes Gutenberg-Universität Mainz Quartärnisierung des Zusatzstoffs Aminoalkyl Methacrylat Copolymer E zur Verbesserung der Permeabilität und Löslichkeit von Arzneistoffen
PT2266581E (pt) 2008-03-18 2016-01-27 Aleksander Vladimirovich Dikovskiy Composição farmacológica de antibióticos e prebióticos para prevenir e tratar disbiose durante terapia antibacteriana
US20090280169A1 (en) * 2008-05-07 2009-11-12 Merrion Research Iii Limited Compositions of peptides and processes of preparation thereof
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
CA2727630A1 (en) * 2008-06-13 2009-12-17 Glaxo Group Limited Pharmaceutical formulations
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
IT1393244B1 (it) * 2008-07-18 2012-04-12 Universita' Degli Studi Di Milano Sistema per il rilascio al colon di farmaci suscettibili di degradazione enzimatica e/o scarsamente assorbiti nel tratto gastrointestinale
CN104958298A (zh) 2009-09-18 2015-10-07 阿得罗公司 阿片样受体拮抗剂用于胃肠道疾病的用途
WO2011084618A2 (en) * 2009-12-16 2011-07-14 Nod Pharmaceuticals, Inc. Compositions and methods for oral drug delivery
CN102552919B (zh) * 2010-12-15 2018-03-27 上海安博生物医药股份有限公司 一种给药组合物及其制备和使用方法
US20110142889A1 (en) * 2009-12-16 2011-06-16 Nod Pharmaceuticals, Inc. Compositions and methods for oral drug delivery
HU230560B1 (hu) * 2010-07-30 2016-12-28 Péter Hajnal pH-függő szakaszos és nyújtott hatóanyagleadású gyógyszerkészítmény
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US10653631B2 (en) 2011-09-07 2020-05-19 Roland SAUR-BROSCH Optimal colon targeting technology
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
CA2885680C (en) * 2011-09-07 2022-10-04 Roland Saur-Brosch Formulation for the controlled release of one or several substances in the digestive tract of a mammal.
RU2014141201A (ru) 2012-03-29 2016-05-20 ТЕРАБАЙОМ, ЭлЭлСи Композиции для желудочно-кишечной сайт-специфической пероральной вакцинации, проявляющие активность в подвздошной кишке и аппендиксе
US20140066837A1 (en) 2012-07-26 2014-03-06 Ronald L. Moy Skin care compositions and methods
WO2014131024A2 (en) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP6464142B2 (ja) 2013-03-14 2019-02-06 セラバイオーム，エルエルシー プロバイオティクス生物及び／又は治療剤の標的化胃腸管デリバリー
EP2970384A1 (de) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonisten der guanylatcyclase und deren verwendungen
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
CN203539304U (zh) * 2013-07-08 2014-04-16 南方医科大学南方医院 一种消化道探路胶囊
EP3054969B1 (de) 2013-10-10 2021-03-10 Bausch Health Ireland Limited Gunaylatcyclase-cyclase-agonisten zur behandlung von opioidinduzierten störungen
US10182993B2 (en) 2015-04-06 2019-01-22 Patheon Softgels Inc. Compositions for colonic delivery of drugs
CN108884130B (zh) 2016-01-11 2022-09-13 博士医疗爱尔兰有限公司 用于治疗溃疡性结肠炎的制剂和方法
TWI730230B (zh) * 2018-05-22 2021-06-11 大陸商合肥合源藥業有限公司 乳果糖糖苷化合物、其製備方法及其用途
US11590161B2 (en) 2018-08-13 2023-02-28 Viscera Labs, Inc. Therapeutic composition and methods
US11524029B2 (en) 2018-08-13 2022-12-13 Viscera Labs, Inc. Therapeutic composition and methods

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1204363B (de) 1963-09-10 1965-11-04 Hoffmann La Roche Verfahren zur Herstellung einer oralen Arzneizubereitung, die ihren Wirkstoff erst im Ileum abgibt
US4863744A (en) * 1984-09-17 1989-09-05 Alza Corporation Intestine drug delivery
JPS6261916A (ja) * 1985-09-12 1987-03-18 Fujisawa Pharmaceut Co Ltd 持続性製剤
US4968508A (en) * 1987-02-27 1990-11-06 Eli Lilly And Company Sustained release matrix
US5068110A (en) * 1987-09-29 1991-11-26 Warner-Lambert Company Stabilization of enteric coated dosage form
IT1246382B (it) * 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
JPH0813748B2 (ja) * 1990-04-23 1996-02-14 帝國製薬株式会社 大腸崩壊性ポリペプチド系経口製剤
HU210497B (en) * 1990-05-04 1995-04-28 Perio Prod Ltd Process for production of modified pectin
IL98087A (en) * 1990-05-04 1996-11-14 Perio Prod Ltd Preparation for dispensing drugs in the colon
JPH064531B2 (ja) * 1990-06-04 1994-01-19 アイセロ化学株式会社 大腸崩壊性硬質カプセル
JP3282832B2 (ja) * 1991-02-19 2002-05-20 帝國製薬株式会社 持続性錠剤
JP2916290B2 (ja) * 1991-03-22 1999-07-05 帝國製薬株式会社 生理活性ポリペプチド含有大腸崩壊経口製剤
US5656290A (en) * 1993-02-26 1997-08-12 The Procter & Gamble Company Bisacodyl dosage form with multiple enteric polymer coatings for colonic delivery
DE69535432T2 (de) * 1994-04-22 2007-12-06 Astellas Pharma Inc. Kolon-spezifisches Arzneistofffreisetzungssystem
US5656294A (en) * 1995-06-07 1997-08-12 Cibus Pharmaceutical, Inc. Colonic delivery of drugs
US5840332A (en) 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
US5840322A (en) * 1996-12-19 1998-11-24 Ramot-University Authority For Applied Research & Industrial Devel. Ltd. Anti-oral-microbial adhesion fraction derived from vaccinium

Also Published As

Publication number Publication date
CN1072964C (zh) 2001-10-17
EP0759303A1 (de) 1997-02-26
US20020044975A1 (en) 2002-04-18
RU2155605C2 (ru) 2000-09-10
DE69535432T2 (de) 2007-12-06
DE69535432D1 (de) 2007-05-03
TW422701B (en) 2001-02-21
DE69528583T2 (de) 2003-07-10
EP1252896A2 (de) 2002-10-30
ATE357221T1 (de) 2007-04-15
US6368629B1 (en) 2002-04-09
AU689250B2 (en) 1998-03-26
EP1252896B1 (de) 2007-03-21
WO1995028963A1 (fr) 1995-11-02
US6506407B2 (en) 2003-01-14
AU2266895A (en) 1995-11-16
EP1252896A3 (de) 2003-10-08
DE69528583D1 (de) 2002-11-21
ES2283503T3 (es) 2007-11-01
CN1146158A (zh) 1997-03-26
EP0759303B1 (de) 2002-10-16
KR100388569B1 (ko) 2003-10-11
JP3867171B2 (ja) 2007-01-10
ES2188657T3 (es) 2003-07-01
EP0759303A4 (de) 1998-05-06

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