IT1393244B1 - Sistema per il rilascio al colon di farmaci suscettibili di degradazione enzimatica e/o scarsamente assorbiti nel tratto gastrointestinale - Google Patents

Sistema per il rilascio al colon di farmaci suscettibili di degradazione enzimatica e/o scarsamente assorbiti nel tratto gastrointestinale

Info

Publication number
IT1393244B1
IT1393244B1 ITMI2008A001313A ITMI20081313A IT1393244B1 IT 1393244 B1 IT1393244 B1 IT 1393244B1 IT MI2008A001313 A ITMI2008A001313 A IT MI2008A001313A IT MI20081313 A ITMI20081313 A IT MI20081313A IT 1393244 B1 IT1393244 B1 IT 1393244B1
Authority
IT
Italy
Prior art keywords
shortly
colon
absorbed
release
gastrointestinal tract
Prior art date
Application number
ITMI2008A001313A
Other languages
English (en)
Inventor
Lucia Zema
Luca Palugan
Maria Edvige Sangalli
Andrea Gazzaniga
Curto Maria Dorly Del
Alessandra Maroni
Original Assignee
Universita' Degli Studi Di Milano
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universita' Degli Studi Di Milano filed Critical Universita' Degli Studi Di Milano
Priority to ITMI2008A001313A priority Critical patent/IT1393244B1/it
Priority to PCT/IB2009/006266 priority patent/WO2010007515A2/en
Priority to JP2011518023A priority patent/JP2011528344A/ja
Priority to US13/054,149 priority patent/US20110250238A1/en
Priority to EP09795537A priority patent/EP2317986A2/en
Publication of ITMI20081313A1 publication Critical patent/ITMI20081313A1/it
Application granted granted Critical
Publication of IT1393244B1 publication Critical patent/IT1393244B1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ITMI2008A001313A 2008-07-18 2008-07-18 Sistema per il rilascio al colon di farmaci suscettibili di degradazione enzimatica e/o scarsamente assorbiti nel tratto gastrointestinale IT1393244B1 (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ITMI2008A001313A IT1393244B1 (it) 2008-07-18 2008-07-18 Sistema per il rilascio al colon di farmaci suscettibili di degradazione enzimatica e/o scarsamente assorbiti nel tratto gastrointestinale
PCT/IB2009/006266 WO2010007515A2 (en) 2008-07-18 2009-07-17 System for the colon delivery of drugs subject to enzyme degradation and/or poorly absorbed in the gastrointestinal tract
JP2011518023A JP2011528344A (ja) 2008-07-18 2009-07-17 胃腸管において酵素分解に付される、および／または吸収されにくい薬剤の結腸への送達系
US13/054,149 US20110250238A1 (en) 2008-07-18 2009-07-17 System for the colon delivery of drugs subject to enzyme degradation and/or poorly absorbed in the gastrointestinal tract
EP09795537A EP2317986A2 (en) 2008-07-18 2009-07-17 System for the colon delivery of drugs subject to enzyme degradation and/or poorly absorbed in the gastrointestinal tract

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2008A001313A IT1393244B1 (it) 2008-07-18 2008-07-18 Sistema per il rilascio al colon di farmaci suscettibili di degradazione enzimatica e/o scarsamente assorbiti nel tratto gastrointestinale

Publications (2)

Publication Number Publication Date
ITMI20081313A1 ITMI20081313A1 (it) 2010-01-19
IT1393244B1 true IT1393244B1 (it) 2012-04-12

Family

ID=40510617

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2008A001313A IT1393244B1 (it) 2008-07-18 2008-07-18 Sistema per il rilascio al colon di farmaci suscettibili di degradazione enzimatica e/o scarsamente assorbiti nel tratto gastrointestinale

Country Status (5)

Country Link
US (1) US20110250238A1 (it)
EP (1) EP2317986A2 (it)
JP (1) JP2011528344A (it)
IT (1) IT1393244B1 (it)
WO (1) WO2010007515A2 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012021455A2 (pt) 2010-02-25 2016-05-31 Evonik Roehm Gmbh formulação farmacêutica ou nutracêutica.
BR112014003117A2 (pt) 2011-08-12 2017-06-13 Boehringer Ingelheim Vetmedica Gmbh inibidores da corrente funny (if) para uso em um método de tratamento e prevenção de insuficiência cardíaca em felino
AU2012388441B2 (en) * 2012-08-27 2017-07-27 Evonik Operations Gmbh Pharmaceutical or nutraceutical composition with sustained release characteristic and with resistance against the influence of ethanol
EP3256114A4 (en) 2015-02-09 2018-11-21 Entera Bio Ltd. Treatment of osteoporosis
US10182993B2 (en) 2015-04-06 2019-01-22 Patheon Softgels Inc. Compositions for colonic delivery of drugs
EP3500291A4 (en) * 2016-08-17 2020-03-11 Entera Bio Ltd. FORMULATIONS FOR THE ORAL ADMINISTRATION OF ACTIVE AGENTS
CN108653233A (zh) * 2017-04-01 2018-10-16 苏州苏融生物医药有限公司 一种具有生物粘附性载多肽蛋白类药物固体颗粒物、包含其的制剂、制备方法及用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4101650A (en) * 1977-04-06 1978-07-18 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Pepstatin floating minicapsules
IL68769A (en) * 1983-05-23 1986-02-28 Hadassah Med Org Pharmaceutical compositions containing insulin for oral administration
IT1230576B (it) * 1988-10-20 1991-10-28 Angeli Inst Spa Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
IT1260505B (it) 1992-06-01 1996-04-09 Poli Ind Chimica Spa Sistemi farmaceutici orali a cessione ritardata per il rilascio specifico nel colon
ATE226090T1 (de) * 1994-04-22 2002-11-15 Yamanouchi Pharma Co Ltd Kolon-spezifisches arzneistofffreisetzungssystem
US6692766B1 (en) * 1994-06-15 2004-02-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Controlled release oral drug delivery system
US20010006980A1 (en) 1998-10-15 2001-07-05 Harada Shun-Ichi Methods for stimulating bone formation
US20040037879A1 (en) * 2001-11-02 2004-02-26 Adusumilli Prasad S. Oral controlled release forms useful for reducing or preventing nicotine cravings
SE0103765D0 (sv) 2001-11-09 2001-11-09 Astrazeneca Ab New use
AU2003201071A1 (en) * 2002-01-15 2003-07-30 Ranbaxy Laboratories Limited Stable pharmaceutical compositions comprising ace inhibitor(s)
DE10231466C1 (de) 2002-07-05 2003-07-10 Pfaff Ind Masch Näheinheit mit einer Vorrichtung zum Ablenken des Greiferfadens
JP2004167178A (ja) * 2002-11-15 2004-06-17 Masashi Takahashi タン白質の経口投与法
FI20030929A (fi) 2003-06-19 2004-12-20 Nokia Corp Menetelmä ja järjestelyjä langattoman tiedonsiirron toteuttamiseksi kulkuvälineessä
TWI354569B (en) * 2004-05-28 2011-12-21 Bristol Myers Squibb Co Coated tablet formulation and method
WO2006035418A2 (en) * 2004-09-27 2006-04-06 Sigmoid Biotechnologies Limited Microcapsules comprising a methylxanthine and a corticosteroid
US20070172525A1 (en) * 2007-03-15 2007-07-26 Ramesh Sesha Anti-diabetic combinations

Also Published As

Publication number Publication date
WO2010007515A3 (en) 2010-03-25
EP2317986A2 (en) 2011-05-11
WO2010007515A2 (en) 2010-01-21
US20110250238A1 (en) 2011-10-13
ITMI20081313A1 (it) 2010-01-19
JP2011528344A (ja) 2011-11-17

Similar Documents

Publication Publication Date Title
BRPI0915750A2 (pt) sistema de exibição
BR112012007472A2 (pt) "aparelho e sistema"
BRPI0911669A2 (pt) sistema e métodos para o aperfeiçoamento da eficiência da disposição de orifício de catéter
BRPI0918821A2 (pt) acionamento de rolos e sistema de acionamento de rolos
BR112012001371A2 (pt) sistema e montagem de suturação
BRPI0822675A2 (pt) Sistema de display e método
BRPI0814695A2 (pt) Sistema de exibição e aparelho de exibição
BRPI0912241A2 (pt) sistema de descarga
BRPI0906141A2 (pt) sistema de tratamento de pressão reduzida
BRPI0814307A2 (pt) Sistema de tratamento presbiópico
BR112012003867A2 (pt) sistema de visão e exibição integrado
IT1394784B1 (it) Sistema e procedimento di riconoscimento visivo
BRPI0911223A2 (pt) sistema de compressão de gás
BRPI0908979A2 (pt) Sistema com engrenagem
BRPI0916947A2 (pt) sistema de acionamento estereostático
IT1393244B1 (it) Sistema per il rilascio al colon di farmaci suscettibili di degradazione enzimatica e/o scarsamente assorbiti nel tratto gastrointestinale
BRPI0918667A2 (pt) sistema de engates de vagão ferroviário e método
BRPI0908231A2 (pt) Sistema de liberação de fármaco com efeito estabilizante
BRPI0923956A2 (pt) sistema de cooperação meio-ambiental e troca de benefícios vitais
BRPI1006770A2 (pt) arpão e sistema de ancoragem
BRPI0917782A2 (pt) sistema e método
BRPI0907058A2 (pt) Sistema de vacinação de suínos
BRPI0909653A2 (pt) sistema terapêutico transdérmico com membrama estabilizada
BRPI0905071A2 (pt) Sistema e terminal
BRPI0919969A2 (pt) sistema de conexão para painéis pré-fabricados