ES2188657T3 - Sistema para la liberacion especifica en el colon de un farmaco. - Google Patents
Sistema para la liberacion especifica en el colon de un farmaco.Info
- Publication number
- ES2188657T3 ES2188657T3 ES95916009T ES95916009T ES2188657T3 ES 2188657 T3 ES2188657 T3 ES 2188657T3 ES 95916009 T ES95916009 T ES 95916009T ES 95916009 T ES95916009 T ES 95916009T ES 2188657 T3 ES2188657 T3 ES 2188657T3
- Authority
- ES
- Spain
- Prior art keywords
- colon
- drug
- pharmaco
- enterobacteria
- organic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
- A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
SISTEMA PARA LIBERAR UN MEDICAMENTO DE FORMA ESPECIFICA EN EL COLON DEL TRACTO GASTROINTESTINAL, QUE INCLUYE UN MEDICAMENTO (B) CUBIERTO CON UN MATERIAL POLIMERICO SOLUBLE EN ACIDO ORGANICO (A) Y UN SACARIDO (C) QUE GENERA RAPIDAMENTE UN ACIDO ORGANICO MEDIANTE LA ACCION DE ENTEROBACTERIAS EN LA PARTE INFERIOR DEL TRACTO GASTROINTESTINAL; PREPARADO ORAL PARA LA LIBERACION DE MEDICACION ESPECIFICA PARA EL COLON, QUE INCLUYE UN COMPUESTO QUE TIENE UN MEDICAMENTO (B) CUBIERTO CON UN MATERIAL POLIMERICO SOLUBLE EN ACIDO ORGANICO (A) Y UN SACARIDO (C) QUE GENERA RAPIDAMENTE UN ACIDO ORGANICO MEDIANTE LA ACCION DE ENTEROBACTERIAS EN LA PARTE INFERIOR DEL TRACTO GASTROINTESTINAL, ESTANDO CUBIERTA ESTA COMPOSICION CON UN MATERIAL POLIMERICO CE COBERTURA ENTERICA (D). LA INVENCION PROPORCIONA UN SISTEMA DE LIBERACION DEL MEDICAMENTO Y UNA PREPARACION QUE UTILIZA ENTEROBACTERIAS, QUE NO DAN LUGAR A SUSTANCIAS DAÑINAS DEBIDO AL MECANISMO DE COMIENZO DE LIBERACION, Y A QUE MUESTRAN UNA RAPIDA DEGRADACION Y TIENEN MAYOR ESPECIFICIDAD PARA EL COLON.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8511494 | 1994-04-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2188657T3 true ES2188657T3 (es) | 2003-07-01 |
Family
ID=13849609
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02077556T Expired - Lifetime ES2283503T3 (es) | 1994-04-22 | 1995-04-19 | Sistema de liberacion de farmaco especifico de colon. |
ES95916009T Expired - Lifetime ES2188657T3 (es) | 1994-04-22 | 1995-04-19 | Sistema para la liberacion especifica en el colon de un farmaco. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02077556T Expired - Lifetime ES2283503T3 (es) | 1994-04-22 | 1995-04-19 | Sistema de liberacion de farmaco especifico de colon. |
Country Status (12)
Country | Link |
---|---|
US (2) | US6368629B1 (es) |
EP (2) | EP1252896B1 (es) |
JP (1) | JP3867171B2 (es) |
KR (1) | KR100388569B1 (es) |
CN (1) | CN1072964C (es) |
AT (2) | ATE357221T1 (es) |
AU (1) | AU689250B2 (es) |
DE (2) | DE69528583T2 (es) |
ES (2) | ES2283503T3 (es) |
RU (1) | RU2155605C2 (es) |
TW (1) | TW422701B (es) |
WO (1) | WO1995028963A1 (es) |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2283503T3 (es) * | 1994-04-22 | 2007-11-01 | Astellas Pharma Inc. | Sistema de liberacion de farmaco especifico de colon. |
US5912014A (en) * | 1996-03-15 | 1999-06-15 | Unigene Laboratories, Inc. | Oral salmon calcitonin pharmaceutical products |
US5814308A (en) * | 1996-03-26 | 1998-09-29 | Zhang; Ke | Methods for the treatment of gastrointestinal tract disorders |
US5948892A (en) | 1996-12-16 | 1999-09-07 | Amgen Inc. | Analogs of macrophage stimulating protein |
WO1998026767A2 (en) * | 1996-12-17 | 1998-06-25 | Poli Industria Chimica S.P.A. | Site-specific controlled release dosage formulation for mesalamine |
KR100530508B1 (ko) * | 1997-01-09 | 2005-11-23 | 모리나가 뉴교 가부시키가이샤 | 락토페린 정제 |
DE19732903A1 (de) | 1997-07-30 | 1999-02-04 | Falk Pharma Gmbh | Pellet-Formulierung zur Behandlung des Intestinaltraktes |
US6099859A (en) | 1998-03-20 | 2000-08-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral tablet having a unitary core |
WO1999056732A1 (fr) * | 1998-04-30 | 1999-11-11 | Morinaga Milk Industry Co., Ltd. | Comprimes drageifies |
JP2002534139A (ja) * | 1999-01-05 | 2002-10-15 | マサチューセッツ・アイ・アンド・イア・インファーマリー | 網膜と脈絡膜への経強膜徐放性薬剤標的送達 |
US6355270B1 (en) * | 1999-01-11 | 2002-03-12 | The Regents Of The University Of California | Particles for oral delivery of peptides and proteins |
IT1312569B1 (it) * | 1999-05-21 | 2002-04-22 | Raffaele Ansovini | Uso dell'enzima gssg reduttasi per il trattamento terapeutico e laprofilassi di pazienti infettati da hiv. |
ATE314091T1 (de) * | 1999-06-09 | 2006-01-15 | Mochida Pharm Co Ltd | System für wirkstofffreisetzung im unteren verdauungstrakt |
ATE251449T1 (de) | 1999-06-14 | 2003-10-15 | Cosmo Spa | Geschmacksmaskierte orale pharmazeutische zusammensetzungen mit kontrollierter abgabe |
US8895064B2 (en) | 1999-06-14 | 2014-11-25 | Cosmo Technologies Limited | Controlled release and taste masking oral pharmaceutical composition |
CA2373940A1 (en) | 1999-07-02 | 2001-01-11 | Hisamitsu Pharmaceutical Co., Inc. | Medicinal compositions for treating colorectal cancer |
AU778049B2 (en) | 1999-08-09 | 2004-11-11 | Dainippon Sumitomo Pharma Co., Ltd. | Solid preparation containing chitosan powder and process for producing the same |
JP4524009B2 (ja) * | 1999-08-09 | 2010-08-11 | 大日本住友製薬株式会社 | 大腸内放出性カプセル製剤 |
US8178150B2 (en) | 2000-02-22 | 2012-05-15 | Suzanne Jaffe Stillman | Water containing soluble fiber |
US7892586B2 (en) | 2001-02-22 | 2011-02-22 | Suzanne Jaffe Stillman | Water containing soluble fiber |
DE60116758T2 (de) * | 2000-05-18 | 2006-11-02 | Therics, Inc. | Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform |
US20050175687A1 (en) * | 2001-01-30 | 2005-08-11 | Mcallister Stephen M. | Pharmaceutical formulations |
GB0102342D0 (en) * | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
US7842308B2 (en) | 2001-01-30 | 2010-11-30 | Smithkline Beecham Limited | Pharmaceutical formulation |
US7883721B2 (en) | 2001-01-30 | 2011-02-08 | Smithkline Beecham Limited | Pharmaceutical formulation |
US7316819B2 (en) * | 2001-03-08 | 2008-01-08 | Unigene Laboratories, Inc. | Oral peptide pharmaceutical dosage form and method of production |
WO2002085415A1 (en) * | 2001-04-17 | 2002-10-31 | Biomatrix, Inc | Non-digestible sugar-coated products and process |
AU2002316738B2 (en) | 2001-07-18 | 2009-01-08 | Euro-Celtique S.A. | Pharmaceutical combinations of oxycodone and naloxone |
US20030044458A1 (en) * | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
AU2011205217B2 (en) * | 2001-08-06 | 2013-06-13 | Euro-Celtique S.A. | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
US7196059B2 (en) * | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
JP2003201256A (ja) * | 2001-12-28 | 2003-07-18 | Hisamitsu Pharmaceut Co Inc | 大腸送達性経口医薬製剤、大腸癌治療用経口医薬製剤および大腸炎治療用経口医薬製剤 |
AU2003201886A1 (en) * | 2002-01-16 | 2003-07-30 | Yamanouchi Pharmaceutical Co., Ltd. | Medicinal compositions for improving oral absorption |
WO2003092665A2 (en) * | 2002-05-02 | 2003-11-13 | Massachusetts Eye And Ear Infirmary | Ocular drug delivery systems and use thereof |
JP2004075582A (ja) * | 2002-08-13 | 2004-03-11 | Takeda Chem Ind Ltd | 固形医薬組成物に処方される有効成分以外の成分の安定化方法 |
ATE448775T1 (de) * | 2002-08-29 | 2009-12-15 | Activbiotics Pharma Llc | Rifalazil zur behandlung von infektionen mit clostridium difficile |
DE10260921A1 (de) * | 2002-12-20 | 2004-07-01 | Röhm GmbH & Co. KG | Verfahren zum Überziehen von Substraten für pharmazeutische Anwendungen mit einem Gemisch aus zwei filmbildenden Überzugsmitteln |
US8088734B2 (en) | 2003-01-21 | 2012-01-03 | Unigene Laboratories Inc. | Oral delivery of peptides |
US20060167435A1 (en) * | 2003-02-18 | 2006-07-27 | Adamis Anthony P | Transscleral drug delivery device and related methods |
GB0310919D0 (en) * | 2003-05-13 | 2003-06-18 | West Pharm Serv Drug Res Ltd | Pharmaceutical compositions |
US20050142191A1 (en) * | 2003-06-23 | 2005-06-30 | Neurochem (International) Limited | Pharmaceutical formulations of amyloid inhibiting compounds |
US20060079578A1 (en) * | 2003-06-23 | 2006-04-13 | Julie Laurin | Pharmaceutical formulations of amyloid inhibiting compounds |
TW200526274A (en) | 2003-07-21 | 2005-08-16 | Smithkline Beecham Plc | Pharmaceutical formulations |
US7737133B2 (en) | 2003-09-03 | 2010-06-15 | Agi Therapeutics Ltd. | Formulations and methods of treating inflammatory bowel disease |
US7825106B2 (en) | 2003-09-03 | 2010-11-02 | Agi Therapeutics Ltd. | Modified release formulations and methods of treating inflammatory bowel disease |
US20050123596A1 (en) * | 2003-09-23 | 2005-06-09 | Kohane Daniel S. | pH-triggered microparticles |
US7943179B2 (en) * | 2003-09-23 | 2011-05-17 | Massachusetts Institute Of Technology | pH triggerable polymeric particles |
EP1684733B1 (en) * | 2003-11-21 | 2011-09-21 | Commonwealth Scientific And Industrial Research Organisation | G i tract delivery systems |
US7670624B2 (en) | 2004-01-29 | 2010-03-02 | Astella Pharma Inc. | Gastrointestinal-specific multiple drug release system |
TW201240679A (en) | 2004-03-12 | 2012-10-16 | Capsugel Belgium Nv | Pharmaceutical formulations |
WO2005105851A1 (en) * | 2004-04-28 | 2005-11-10 | Commonwealth Scientific & Industrial Research Organisation | Starch treatment process |
US7645460B2 (en) * | 2004-05-24 | 2010-01-12 | The Procter & Gamble Company | Dosage forms of risedronate |
US7645459B2 (en) * | 2004-05-24 | 2010-01-12 | The Procter & Gamble Company | Dosage forms of bisphosphonates |
US20080286359A1 (en) * | 2004-05-24 | 2008-11-20 | Richard John Dansereau | Low Dosage Forms Of Risedronate Or Its Salts |
US20080287400A1 (en) * | 2004-05-24 | 2008-11-20 | Richard John Dansereau | Low Dosage Forms Of Risedronate Or Its Salts |
RU2284832C2 (ru) * | 2004-08-30 | 2006-10-10 | Николай Александрович Киселев | Антимикробная композиция для перорального введения |
WO2007069073A2 (en) * | 2005-04-12 | 2007-06-21 | Neurochem (International) Limited | Pharmaceutical formulations of amyloid inhibiting compounds |
US20060280795A1 (en) * | 2005-06-08 | 2006-12-14 | Dexcel Pharma Technologies, Ltd. | Specific time-delayed burst profile delivery system |
WO2007038867A1 (en) * | 2005-10-04 | 2007-04-12 | Mistral Pharma Inc. | Controlled-release oral dosage form |
GB0607534D0 (en) * | 2006-04-13 | 2006-05-24 | Univ London Pharmacy | Colonic drug delivery formulation |
EP2106732B1 (en) * | 2007-01-30 | 2016-03-16 | Olympus Corporation | Device for checking for lumen passage and method of producing device for checking for lumen passage |
JP2010523554A (ja) | 2007-04-04 | 2010-07-15 | シグモイド・ファーマ・リミテッド | タクロリムスの医薬組成物 |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
ES2393885T7 (es) | 2007-06-04 | 2014-01-30 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
US20090036414A1 (en) * | 2007-08-02 | 2009-02-05 | Mutual Pharmaceutical Company, Inc. | Mesalamine Formulations |
DE102007060175A1 (de) * | 2007-12-13 | 2009-06-18 | Johannes Gutenberg-Universität Mainz | Quartärnisierung des Zusatzstoffs Aminoalkyl Methacrylat Copolymer E zur Verbesserung der Permeabilität und Löslichkeit von Arzneistoffen |
BRPI0822359A2 (pt) | 2008-03-18 | 2015-07-14 | Aleksander Vladimirovich Dikovskiy | Composição farmacêutica de antibióticos e prebióticos para prevenir e tratar disbiose durante terapia antibacteriana |
WO2009137078A1 (en) * | 2008-05-07 | 2009-11-12 | Merrion Research Iii Limited | Compositions of peptides and processes of preparation thereof |
ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
WO2009150228A2 (en) * | 2008-06-13 | 2009-12-17 | Glaxo Group Limited | Pharmaceutical formulations |
AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
IT1393244B1 (it) * | 2008-07-18 | 2012-04-12 | Universita' Degli Studi Di Milano | Sistema per il rilascio al colon di farmaci suscettibili di degradazione enzimatica e/o scarsamente assorbiti nel tratto gastrointestinale |
CN104958298A (zh) | 2009-09-18 | 2015-10-07 | 阿得罗公司 | 阿片样受体拮抗剂用于胃肠道疾病的用途 |
CA2784120A1 (en) * | 2009-12-16 | 2011-07-14 | Nod Pharmaceuticals, Inc. | Compositions and methods for oral drug delivery |
CN102552919B (zh) * | 2010-12-15 | 2018-03-27 | 上海安博生物医药股份有限公司 | 一种给药组合物及其制备和使用方法 |
US20110142889A1 (en) * | 2009-12-16 | 2011-06-16 | Nod Pharmaceuticals, Inc. | Compositions and methods for oral drug delivery |
HU230560B1 (hu) * | 2010-07-30 | 2016-12-28 | Péter Hajnal | pH-függő szakaszos és nyújtott hatóanyagleadású gyógyszerkészítmény |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
US10154964B2 (en) | 2011-09-07 | 2018-12-18 | Cosmo Technologies Limited | Controlled release and taste masking oral pharmaceutical composition |
US10653631B2 (en) | 2011-09-07 | 2020-05-19 | Roland SAUR-BROSCH | Optimal colon targeting technology |
US10799460B2 (en) | 2011-09-07 | 2020-10-13 | Roland SAUR-BROSCH | Formulation for the controlled release of one or several substances in the digestive tract of a mammal |
CA3008794C (en) | 2012-03-29 | 2021-03-16 | Therabiome, Llc | Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix |
US20140066837A1 (en) | 2012-07-26 | 2014-03-06 | Ronald L. Moy | Skin care compositions and methods |
AU2014218599C1 (en) | 2013-02-25 | 2018-09-06 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists for use in colonic cleansing |
CA2904389C (en) | 2013-03-14 | 2018-09-18 | Jerome J. Schentag | Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
CN203539304U (zh) * | 2013-07-08 | 2014-04-16 | 南方医科大学南方医院 | 一种消化道探路胶囊 |
EP3054969B1 (en) | 2013-10-10 | 2021-03-10 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of opioid induced dysfunctions |
US10182993B2 (en) | 2015-04-06 | 2019-01-22 | Patheon Softgels Inc. | Compositions for colonic delivery of drugs |
CA3009814A1 (en) | 2016-01-11 | 2017-07-20 | Synergy Pharmaceuticals, Inc. | Formulations and methods for treating ulcerative colitis |
TWI730230B (zh) * | 2018-05-22 | 2021-06-11 | 大陸商合肥合源藥業有限公司 | 乳果糖糖苷化合物、其製備方法及其用途 |
US11590161B2 (en) | 2018-08-13 | 2023-02-28 | Viscera Labs, Inc. | Therapeutic composition and methods |
US11524029B2 (en) | 2018-08-13 | 2022-12-13 | Viscera Labs, Inc. | Therapeutic composition and methods |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1204363B (de) | 1963-09-10 | 1965-11-04 | Hoffmann La Roche | Verfahren zur Herstellung einer oralen Arzneizubereitung, die ihren Wirkstoff erst im Ileum abgibt |
US4863744A (en) * | 1984-09-17 | 1989-09-05 | Alza Corporation | Intestine drug delivery |
JPS6261916A (ja) * | 1985-09-12 | 1987-03-18 | Fujisawa Pharmaceut Co Ltd | 持続性製剤 |
US4968508A (en) * | 1987-02-27 | 1990-11-06 | Eli Lilly And Company | Sustained release matrix |
US5068110A (en) * | 1987-09-29 | 1991-11-26 | Warner-Lambert Company | Stabilization of enteric coated dosage form |
IT1246382B (it) * | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
JPH0813748B2 (ja) * | 1990-04-23 | 1996-02-14 | 帝國製薬株式会社 | 大腸崩壊性ポリペプチド系経口製剤 |
HU210497B (en) * | 1990-05-04 | 1995-04-28 | Perio Prod Ltd | Process for production of modified pectin |
IL98087A (en) * | 1990-05-04 | 1996-11-14 | Perio Prod Ltd | Preparation for dispensing drugs in the colon |
JPH064531B2 (ja) * | 1990-06-04 | 1994-01-19 | アイセロ化学株式会社 | 大腸崩壊性硬質カプセル |
JP3282832B2 (ja) * | 1991-02-19 | 2002-05-20 | 帝國製薬株式会社 | 持続性錠剤 |
JP2916290B2 (ja) * | 1991-03-22 | 1999-07-05 | 帝國製薬株式会社 | 生理活性ポリペプチド含有大腸崩壊経口製剤 |
US5656290A (en) * | 1993-02-26 | 1997-08-12 | The Procter & Gamble Company | Bisacodyl dosage form with multiple enteric polymer coatings for colonic delivery |
ES2283503T3 (es) * | 1994-04-22 | 2007-11-01 | Astellas Pharma Inc. | Sistema de liberacion de farmaco especifico de colon. |
US5656294A (en) * | 1995-06-07 | 1997-08-12 | Cibus Pharmaceutical, Inc. | Colonic delivery of drugs |
US5840332A (en) | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
US5840322A (en) * | 1996-12-19 | 1998-11-24 | Ramot-University Authority For Applied Research & Industrial Devel. Ltd. | Anti-oral-microbial adhesion fraction derived from vaccinium |
-
1995
- 1995-04-19 ES ES02077556T patent/ES2283503T3/es not_active Expired - Lifetime
- 1995-04-19 AU AU22668/95A patent/AU689250B2/en not_active Ceased
- 1995-04-19 EP EP02077556A patent/EP1252896B1/en not_active Expired - Lifetime
- 1995-04-19 ES ES95916009T patent/ES2188657T3/es not_active Expired - Lifetime
- 1995-04-19 KR KR1019960705901A patent/KR100388569B1/ko not_active IP Right Cessation
- 1995-04-19 DE DE69528583T patent/DE69528583T2/de not_active Expired - Lifetime
- 1995-04-19 AT AT02077556T patent/ATE357221T1/de not_active IP Right Cessation
- 1995-04-19 CN CN95192640A patent/CN1072964C/zh not_active Expired - Fee Related
- 1995-04-19 AT AT95916009T patent/ATE226090T1/de not_active IP Right Cessation
- 1995-04-19 RU RU96122649/14A patent/RU2155605C2/ru not_active IP Right Cessation
- 1995-04-19 DE DE69535432T patent/DE69535432T2/de not_active Expired - Lifetime
- 1995-04-19 EP EP95916009A patent/EP0759303B1/en not_active Expired - Lifetime
- 1995-04-19 JP JP52751995A patent/JP3867171B2/ja not_active Expired - Fee Related
- 1995-04-19 WO PCT/JP1995/000766 patent/WO1995028963A1/ja active IP Right Grant
- 1995-04-21 TW TW084103940A patent/TW422701B/zh not_active IP Right Cessation
-
1998
- 1998-10-30 US US09/183,339 patent/US6368629B1/en not_active Expired - Lifetime
-
2001
- 2001-09-14 US US09/952,992 patent/US6506407B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69535432D1 (de) | 2007-05-03 |
AU2266895A (en) | 1995-11-16 |
EP0759303B1 (en) | 2002-10-16 |
ES2283503T3 (es) | 2007-11-01 |
EP1252896A3 (en) | 2003-10-08 |
EP1252896A2 (en) | 2002-10-30 |
TW422701B (en) | 2001-02-21 |
US20020044975A1 (en) | 2002-04-18 |
EP0759303A1 (en) | 1997-02-26 |
DE69528583D1 (de) | 2002-11-21 |
EP1252896B1 (en) | 2007-03-21 |
US6506407B2 (en) | 2003-01-14 |
US6368629B1 (en) | 2002-04-09 |
DE69528583T2 (de) | 2003-07-10 |
ATE357221T1 (de) | 2007-04-15 |
KR100388569B1 (ko) | 2003-10-11 |
RU2155605C2 (ru) | 2000-09-10 |
EP0759303A4 (en) | 1998-05-06 |
DE69535432T2 (de) | 2007-12-06 |
JP3867171B2 (ja) | 2007-01-10 |
ATE226090T1 (de) | 2002-11-15 |
CN1072964C (zh) | 2001-10-17 |
WO1995028963A1 (fr) | 1995-11-02 |
CN1146158A (zh) | 1997-03-26 |
AU689250B2 (en) | 1998-03-26 |
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