ES2188657T3 - Sistema para la liberacion especifica en el colon de un farmaco. - Google Patents

Sistema para la liberacion especifica en el colon de un farmaco.

Info

Publication number
ES2188657T3
ES2188657T3 ES95916009T ES95916009T ES2188657T3 ES 2188657 T3 ES2188657 T3 ES 2188657T3 ES 95916009 T ES95916009 T ES 95916009T ES 95916009 T ES95916009 T ES 95916009T ES 2188657 T3 ES2188657 T3 ES 2188657T3
Authority
ES
Spain
Prior art keywords
colon
drug
pharmaco
enterobacteria
organic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95916009T
Other languages
English (en)
Inventor
Shunsuke Watanabe
Hitoshi Kawai
Masataka Katsuma
Muneo Fukui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2188657T3 publication Critical patent/ES2188657T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

SISTEMA PARA LIBERAR UN MEDICAMENTO DE FORMA ESPECIFICA EN EL COLON DEL TRACTO GASTROINTESTINAL, QUE INCLUYE UN MEDICAMENTO (B) CUBIERTO CON UN MATERIAL POLIMERICO SOLUBLE EN ACIDO ORGANICO (A) Y UN SACARIDO (C) QUE GENERA RAPIDAMENTE UN ACIDO ORGANICO MEDIANTE LA ACCION DE ENTEROBACTERIAS EN LA PARTE INFERIOR DEL TRACTO GASTROINTESTINAL; PREPARADO ORAL PARA LA LIBERACION DE MEDICACION ESPECIFICA PARA EL COLON, QUE INCLUYE UN COMPUESTO QUE TIENE UN MEDICAMENTO (B) CUBIERTO CON UN MATERIAL POLIMERICO SOLUBLE EN ACIDO ORGANICO (A) Y UN SACARIDO (C) QUE GENERA RAPIDAMENTE UN ACIDO ORGANICO MEDIANTE LA ACCION DE ENTEROBACTERIAS EN LA PARTE INFERIOR DEL TRACTO GASTROINTESTINAL, ESTANDO CUBIERTA ESTA COMPOSICION CON UN MATERIAL POLIMERICO CE COBERTURA ENTERICA (D). LA INVENCION PROPORCIONA UN SISTEMA DE LIBERACION DEL MEDICAMENTO Y UNA PREPARACION QUE UTILIZA ENTEROBACTERIAS, QUE NO DAN LUGAR A SUSTANCIAS DAÑINAS DEBIDO AL MECANISMO DE COMIENZO DE LIBERACION, Y A QUE MUESTRAN UNA RAPIDA DEGRADACION Y TIENEN MAYOR ESPECIFICIDAD PARA EL COLON.
ES95916009T 1994-04-22 1995-04-19 Sistema para la liberacion especifica en el colon de un farmaco. Expired - Lifetime ES2188657T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8511494 1994-04-22

Publications (1)

Publication Number Publication Date
ES2188657T3 true ES2188657T3 (es) 2003-07-01

Family

ID=13849609

Family Applications (2)

Application Number Title Priority Date Filing Date
ES02077556T Expired - Lifetime ES2283503T3 (es) 1994-04-22 1995-04-19 Sistema de liberacion de farmaco especifico de colon.
ES95916009T Expired - Lifetime ES2188657T3 (es) 1994-04-22 1995-04-19 Sistema para la liberacion especifica en el colon de un farmaco.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES02077556T Expired - Lifetime ES2283503T3 (es) 1994-04-22 1995-04-19 Sistema de liberacion de farmaco especifico de colon.

Country Status (12)

Country Link
US (2) US6368629B1 (es)
EP (2) EP1252896B1 (es)
JP (1) JP3867171B2 (es)
KR (1) KR100388569B1 (es)
CN (1) CN1072964C (es)
AT (2) ATE357221T1 (es)
AU (1) AU689250B2 (es)
DE (2) DE69528583T2 (es)
ES (2) ES2283503T3 (es)
RU (1) RU2155605C2 (es)
TW (1) TW422701B (es)
WO (1) WO1995028963A1 (es)

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Also Published As

Publication number Publication date
DE69535432D1 (de) 2007-05-03
AU2266895A (en) 1995-11-16
EP0759303B1 (en) 2002-10-16
ES2283503T3 (es) 2007-11-01
EP1252896A3 (en) 2003-10-08
EP1252896A2 (en) 2002-10-30
TW422701B (en) 2001-02-21
US20020044975A1 (en) 2002-04-18
EP0759303A1 (en) 1997-02-26
DE69528583D1 (de) 2002-11-21
EP1252896B1 (en) 2007-03-21
US6506407B2 (en) 2003-01-14
US6368629B1 (en) 2002-04-09
DE69528583T2 (de) 2003-07-10
ATE357221T1 (de) 2007-04-15
KR100388569B1 (ko) 2003-10-11
RU2155605C2 (ru) 2000-09-10
EP0759303A4 (en) 1998-05-06
DE69535432T2 (de) 2007-12-06
JP3867171B2 (ja) 2007-01-10
ATE226090T1 (de) 2002-11-15
CN1072964C (zh) 2001-10-17
WO1995028963A1 (fr) 1995-11-02
CN1146158A (zh) 1997-03-26
AU689250B2 (en) 1998-03-26

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