ES2188657T3 - Sistema para la liberacion especifica en el colon de un farmaco. - Google Patents
Sistema para la liberacion especifica en el colon de un farmaco.Info
- Publication number
- ES2188657T3 ES2188657T3 ES95916009T ES95916009T ES2188657T3 ES 2188657 T3 ES2188657 T3 ES 2188657T3 ES 95916009 T ES95916009 T ES 95916009T ES 95916009 T ES95916009 T ES 95916009T ES 2188657 T3 ES2188657 T3 ES 2188657T3
- Authority
- ES
- Spain
- Prior art keywords
- colon
- drug
- pharmaco
- enterobacteria
- organic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
- A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
SISTEMA PARA LIBERAR UN MEDICAMENTO DE FORMA ESPECIFICA EN EL COLON DEL TRACTO GASTROINTESTINAL, QUE INCLUYE UN MEDICAMENTO (B) CUBIERTO CON UN MATERIAL POLIMERICO SOLUBLE EN ACIDO ORGANICO (A) Y UN SACARIDO (C) QUE GENERA RAPIDAMENTE UN ACIDO ORGANICO MEDIANTE LA ACCION DE ENTEROBACTERIAS EN LA PARTE INFERIOR DEL TRACTO GASTROINTESTINAL; PREPARADO ORAL PARA LA LIBERACION DE MEDICACION ESPECIFICA PARA EL COLON, QUE INCLUYE UN COMPUESTO QUE TIENE UN MEDICAMENTO (B) CUBIERTO CON UN MATERIAL POLIMERICO SOLUBLE EN ACIDO ORGANICO (A) Y UN SACARIDO (C) QUE GENERA RAPIDAMENTE UN ACIDO ORGANICO MEDIANTE LA ACCION DE ENTEROBACTERIAS EN LA PARTE INFERIOR DEL TRACTO GASTROINTESTINAL, ESTANDO CUBIERTA ESTA COMPOSICION CON UN MATERIAL POLIMERICO CE COBERTURA ENTERICA (D). LA INVENCION PROPORCIONA UN SISTEMA DE LIBERACION DEL MEDICAMENTO Y UNA PREPARACION QUE UTILIZA ENTEROBACTERIAS, QUE NO DAN LUGAR A SUSTANCIAS DAÑINAS DEBIDO AL MECANISMO DE COMIENZO DE LIBERACION, Y A QUE MUESTRAN UNA RAPIDA DEGRADACION Y TIENEN MAYOR ESPECIFICIDAD PARA EL COLON.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8511494 | 1994-04-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2188657T3 true ES2188657T3 (es) | 2003-07-01 |
Family
ID=13849609
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02077556T Expired - Lifetime ES2283503T3 (es) | 1994-04-22 | 1995-04-19 | Sistema de liberacion de farmaco especifico de colon. |
ES95916009T Expired - Lifetime ES2188657T3 (es) | 1994-04-22 | 1995-04-19 | Sistema para la liberacion especifica en el colon de un farmaco. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02077556T Expired - Lifetime ES2283503T3 (es) | 1994-04-22 | 1995-04-19 | Sistema de liberacion de farmaco especifico de colon. |
Country Status (12)
Country | Link |
---|---|
US (2) | US6368629B1 (es) |
EP (2) | EP1252896B1 (es) |
JP (1) | JP3867171B2 (es) |
KR (1) | KR100388569B1 (es) |
CN (1) | CN1072964C (es) |
AT (2) | ATE357221T1 (es) |
AU (1) | AU689250B2 (es) |
DE (2) | DE69528583T2 (es) |
ES (2) | ES2283503T3 (es) |
RU (1) | RU2155605C2 (es) |
TW (1) | TW422701B (es) |
WO (1) | WO1995028963A1 (es) |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69528583T2 (de) * | 1994-04-22 | 2003-07-10 | Yamanouchi Pharma Co Ltd | Kolon-spezifisches arzneistofffreisetzungssystem |
US5912014A (en) * | 1996-03-15 | 1999-06-15 | Unigene Laboratories, Inc. | Oral salmon calcitonin pharmaceutical products |
US5814308A (en) * | 1996-03-26 | 1998-09-29 | Zhang; Ke | Methods for the treatment of gastrointestinal tract disorders |
US5948892A (en) * | 1996-12-16 | 1999-09-07 | Amgen Inc. | Analogs of macrophage stimulating protein |
AU5775398A (en) * | 1996-12-17 | 1998-07-15 | Poli Industria Chimica S.P.A. | Site-specific controlled release dosage formulation for mesalamine |
DK0955058T3 (da) * | 1997-01-09 | 2004-08-30 | Morinaga Milk Industry Co Ltd | Lactoferrintabletter |
DE19732903A1 (de) | 1997-07-30 | 1999-02-04 | Falk Pharma Gmbh | Pellet-Formulierung zur Behandlung des Intestinaltraktes |
US6099859A (en) * | 1998-03-20 | 2000-08-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral tablet having a unitary core |
DE69915818T2 (de) * | 1998-04-30 | 2005-01-05 | Morinaga Milk Industry Co. Ltd. | Zuckerbeschichtete tabletten |
WO2000040089A1 (en) * | 1999-01-05 | 2000-07-13 | Massachusetts Eye And Ear Infirmary | Targeted transscleral controlled release drug delivery to the retina and choroid |
US6355270B1 (en) * | 1999-01-11 | 2002-03-12 | The Regents Of The University Of California | Particles for oral delivery of peptides and proteins |
IT1312569B1 (it) * | 1999-05-21 | 2002-04-22 | Raffaele Ansovini | Uso dell'enzima gssg reduttasi per il trattamento terapeutico e laprofilassi di pazienti infettati da hiv. |
EP1184038B1 (en) * | 1999-06-09 | 2005-12-28 | Mochida Pharmaceutical Co., Ltd. | System for release in lower digestive tract |
PT1183014E (pt) | 1999-06-14 | 2003-12-31 | Cosmo Spa | Composicoes farmaceuticas orais de libertacao controlada e de dissimulacao de sabor |
US8895064B2 (en) | 1999-06-14 | 2014-11-25 | Cosmo Technologies Limited | Controlled release and taste masking oral pharmaceutical composition |
EP1197228A4 (en) | 1999-07-02 | 2004-03-10 | Hisamitsu Pharmaceutical Co | DRUG COMPOSITIONS FOR THE TREATMENT OF COLORECTAL CANCER |
DE60035421T2 (de) | 1999-08-09 | 2008-03-13 | Dainippon Sumitomo Pharma Co., Ltd. | Chitosanpulver enthaltende feste zubereitungen und verfahren zu deren herstellung |
JP4524009B2 (ja) * | 1999-08-09 | 2010-08-11 | 大日本住友製薬株式会社 | 大腸内放出性カプセル製剤 |
US7892586B2 (en) | 2001-02-22 | 2011-02-22 | Suzanne Jaffe Stillman | Water containing soluble fiber |
US8178150B2 (en) | 2000-02-22 | 2012-05-15 | Suzanne Jaffe Stillman | Water containing soluble fiber |
WO2001087272A2 (en) * | 2000-05-18 | 2001-11-22 | Therics, Inc. | Encapsulating a toxic core within a non-toxic region in an oral dosage form |
US20050175687A1 (en) * | 2001-01-30 | 2005-08-11 | Mcallister Stephen M. | Pharmaceutical formulations |
US7842308B2 (en) | 2001-01-30 | 2010-11-30 | Smithkline Beecham Limited | Pharmaceutical formulation |
GB0102342D0 (en) * | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
US7883721B2 (en) | 2001-01-30 | 2011-02-08 | Smithkline Beecham Limited | Pharmaceutical formulation |
US7316819B2 (en) * | 2001-03-08 | 2008-01-08 | Unigene Laboratories, Inc. | Oral peptide pharmaceutical dosage form and method of production |
WO2002085415A1 (en) * | 2001-04-17 | 2002-10-31 | Biomatrix, Inc | Non-digestible sugar-coated products and process |
DE60230632D1 (de) | 2001-07-18 | 2009-02-12 | Euro Celtique Sa | Pharmazeutische kombinationen von oxycodon und naloxon |
US20030044458A1 (en) * | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
AU2011205217B2 (en) * | 2001-08-06 | 2013-06-13 | Euro-Celtique S.A. | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
US7196059B2 (en) * | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
JP2003201256A (ja) * | 2001-12-28 | 2003-07-18 | Hisamitsu Pharmaceut Co Inc | 大腸送達性経口医薬製剤、大腸癌治療用経口医薬製剤および大腸炎治療用経口医薬製剤 |
US7923025B2 (en) | 2002-01-16 | 2011-04-12 | Astellas Pharma Inc. | Pharmaceutical composition for oral use with improved absorption |
WO2003092665A2 (en) * | 2002-05-02 | 2003-11-13 | Massachusetts Eye And Ear Infirmary | Ocular drug delivery systems and use thereof |
JP2004075582A (ja) * | 2002-08-13 | 2004-03-11 | Takeda Chem Ind Ltd | 固形医薬組成物に処方される有効成分以外の成分の安定化方法 |
DE60330161D1 (de) * | 2002-08-29 | 2009-12-31 | Activbiotics Pharma Llc | Rifalazil zur behandlung von infektionen mit clostridium difficile |
DE10260921A1 (de) * | 2002-12-20 | 2004-07-01 | Röhm GmbH & Co. KG | Verfahren zum Überziehen von Substraten für pharmazeutische Anwendungen mit einem Gemisch aus zwei filmbildenden Überzugsmitteln |
US8088734B2 (en) | 2003-01-21 | 2012-01-03 | Unigene Laboratories Inc. | Oral delivery of peptides |
WO2004073551A2 (en) * | 2003-02-18 | 2004-09-02 | Massachusetts Eye And Ear Infirmary | Transscleral drug delivery device and related methods |
GB0310919D0 (en) * | 2003-05-13 | 2003-06-18 | West Pharm Serv Drug Res Ltd | Pharmaceutical compositions |
US20050142191A1 (en) * | 2003-06-23 | 2005-06-30 | Neurochem (International) Limited | Pharmaceutical formulations of amyloid inhibiting compounds |
US20060079578A1 (en) * | 2003-06-23 | 2006-04-13 | Julie Laurin | Pharmaceutical formulations of amyloid inhibiting compounds |
TW200526274A (en) | 2003-07-21 | 2005-08-16 | Smithkline Beecham Plc | Pharmaceutical formulations |
US7825106B2 (en) | 2003-09-03 | 2010-11-02 | Agi Therapeutics Ltd. | Modified release formulations and methods of treating inflammatory bowel disease |
US7737133B2 (en) | 2003-09-03 | 2010-06-15 | Agi Therapeutics Ltd. | Formulations and methods of treating inflammatory bowel disease |
US7943179B2 (en) * | 2003-09-23 | 2011-05-17 | Massachusetts Institute Of Technology | pH triggerable polymeric particles |
US20050123596A1 (en) * | 2003-09-23 | 2005-06-09 | Kohane Daniel S. | pH-triggered microparticles |
EP1684733B1 (en) * | 2003-11-21 | 2011-09-21 | Commonwealth Scientific And Industrial Research Organisation | G i tract delivery systems |
US7670624B2 (en) * | 2004-01-29 | 2010-03-02 | Astella Pharma Inc. | Gastrointestinal-specific multiple drug release system |
TW201240679A (en) | 2004-03-12 | 2012-10-16 | Capsugel Belgium Nv | Pharmaceutical formulations |
ES2639839T3 (es) * | 2004-04-28 | 2017-10-30 | Commonwealth Scientific And Industrial Research Organisation | Proceso de tratamiento del almidón |
US7645459B2 (en) | 2004-05-24 | 2010-01-12 | The Procter & Gamble Company | Dosage forms of bisphosphonates |
US7645460B2 (en) * | 2004-05-24 | 2010-01-12 | The Procter & Gamble Company | Dosage forms of risedronate |
US20080287400A1 (en) * | 2004-05-24 | 2008-11-20 | Richard John Dansereau | Low Dosage Forms Of Risedronate Or Its Salts |
US20080286359A1 (en) * | 2004-05-24 | 2008-11-20 | Richard John Dansereau | Low Dosage Forms Of Risedronate Or Its Salts |
RU2284832C2 (ru) * | 2004-08-30 | 2006-10-10 | Николай Александрович Киселев | Антимикробная композиция для перорального введения |
CA2611586A1 (en) * | 2005-04-12 | 2007-06-21 | Neurochem (International) Limited | Pharmaceutical formulations of amyloid inhibiting compounds |
US20060280795A1 (en) * | 2005-06-08 | 2006-12-14 | Dexcel Pharma Technologies, Ltd. | Specific time-delayed burst profile delivery system |
WO2007038867A1 (en) * | 2005-10-04 | 2007-04-12 | Mistral Pharma Inc. | Controlled-release oral dosage form |
GB0607534D0 (en) * | 2006-04-13 | 2006-05-24 | Univ London Pharmacy | Colonic drug delivery formulation |
WO2008093554A1 (ja) * | 2007-01-30 | 2008-08-07 | Olympus Medical Systems Corp. | 管腔通過確認装置および管腔通過確認装置の製造方法 |
CN103120653B (zh) | 2007-04-04 | 2015-09-30 | 希格默伊德药业有限公司 | 一种口服药物组合物 |
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US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
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DE102007060175A1 (de) * | 2007-12-13 | 2009-06-18 | Johannes Gutenberg-Universität Mainz | Quartärnisierung des Zusatzstoffs Aminoalkyl Methacrylat Copolymer E zur Verbesserung der Permeabilität und Löslichkeit von Arzneistoffen |
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IT1393244B1 (it) * | 2008-07-18 | 2012-04-12 | Universita' Degli Studi Di Milano | Sistema per il rilascio al colon di farmaci suscettibili di degradazione enzimatica e/o scarsamente assorbiti nel tratto gastrointestinale |
NZ598783A (en) | 2009-09-18 | 2013-07-26 | Adolor Corp | Use of opioid receptor antagonist for gastrointestinal tract disorders |
US20110142889A1 (en) * | 2009-12-16 | 2011-06-16 | Nod Pharmaceuticals, Inc. | Compositions and methods for oral drug delivery |
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CN102552919B (zh) * | 2010-12-15 | 2018-03-27 | 上海安博生物医药股份有限公司 | 一种给药组合物及其制备和使用方法 |
HU230560B1 (hu) * | 2010-07-30 | 2016-12-28 | Péter Hajnal | pH-függő szakaszos és nyújtott hatóanyagleadású gyógyszerkészítmény |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
US10653631B2 (en) | 2011-09-07 | 2020-05-19 | Roland SAUR-BROSCH | Optimal colon targeting technology |
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JP2014529630A (ja) * | 2011-09-07 | 2014-11-13 | ザウラー−ブロシュ、ローラント | 哺乳類の消化管における一つあるいは複数の物質の放出制御製剤 |
CN109172816A (zh) | 2012-03-29 | 2019-01-11 | 塞拉拜姆有限责任公司 | 在回肠和阑尾上有活性的胃肠位点特异性口服接种疫苗制剂 |
US20140066837A1 (en) | 2012-07-26 | 2014-03-06 | Ronald L. Moy | Skin care compositions and methods |
CA2902348C (en) | 2013-02-25 | 2021-11-30 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
RU2015140610A (ru) | 2013-03-14 | 2017-04-17 | ТЕРАБАЙОМ, ЭлЭлСи | Направленная доставка в желудочно-кишечный тракт пробиотических микроорганизмов и/или терапевтических средств |
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CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
CN203539304U (zh) * | 2013-07-08 | 2014-04-16 | 南方医科大学南方医院 | 一种消化道探路胶囊 |
EA201690732A1 (ru) | 2013-10-10 | 2016-12-30 | Синерджи Фармасьютикалз, Инк. | Агонисты гуанилатциклазы, используемые для лечения индуцированных опиоидами дисфункций |
US10182993B2 (en) | 2015-04-06 | 2019-01-22 | Patheon Softgels Inc. | Compositions for colonic delivery of drugs |
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DE1204363B (de) | 1963-09-10 | 1965-11-04 | Hoffmann La Roche | Verfahren zur Herstellung einer oralen Arzneizubereitung, die ihren Wirkstoff erst im Ileum abgibt |
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-
1995
- 1995-04-19 DE DE69528583T patent/DE69528583T2/de not_active Expired - Lifetime
- 1995-04-19 AT AT02077556T patent/ATE357221T1/de not_active IP Right Cessation
- 1995-04-19 ES ES02077556T patent/ES2283503T3/es not_active Expired - Lifetime
- 1995-04-19 WO PCT/JP1995/000766 patent/WO1995028963A1/ja active IP Right Grant
- 1995-04-19 EP EP02077556A patent/EP1252896B1/en not_active Expired - Lifetime
- 1995-04-19 RU RU96122649/14A patent/RU2155605C2/ru not_active IP Right Cessation
- 1995-04-19 AT AT95916009T patent/ATE226090T1/de not_active IP Right Cessation
- 1995-04-19 JP JP52751995A patent/JP3867171B2/ja not_active Expired - Fee Related
- 1995-04-19 ES ES95916009T patent/ES2188657T3/es not_active Expired - Lifetime
- 1995-04-19 CN CN95192640A patent/CN1072964C/zh not_active Expired - Fee Related
- 1995-04-19 EP EP95916009A patent/EP0759303B1/en not_active Expired - Lifetime
- 1995-04-19 DE DE69535432T patent/DE69535432T2/de not_active Expired - Lifetime
- 1995-04-19 AU AU22668/95A patent/AU689250B2/en not_active Ceased
- 1995-04-19 KR KR1019960705901A patent/KR100388569B1/ko not_active IP Right Cessation
- 1995-04-21 TW TW084103940A patent/TW422701B/zh not_active IP Right Cessation
-
1998
- 1998-10-30 US US09/183,339 patent/US6368629B1/en not_active Expired - Lifetime
-
2001
- 2001-09-14 US US09/952,992 patent/US6506407B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CN1072964C (zh) | 2001-10-17 |
EP1252896A2 (en) | 2002-10-30 |
EP1252896A3 (en) | 2003-10-08 |
JP3867171B2 (ja) | 2007-01-10 |
AU2266895A (en) | 1995-11-16 |
RU2155605C2 (ru) | 2000-09-10 |
US6506407B2 (en) | 2003-01-14 |
KR100388569B1 (ko) | 2003-10-11 |
US20020044975A1 (en) | 2002-04-18 |
EP0759303B1 (en) | 2002-10-16 |
ES2283503T3 (es) | 2007-11-01 |
TW422701B (en) | 2001-02-21 |
EP0759303A4 (en) | 1998-05-06 |
DE69535432D1 (de) | 2007-05-03 |
ATE226090T1 (de) | 2002-11-15 |
EP0759303A1 (en) | 1997-02-26 |
DE69528583D1 (de) | 2002-11-21 |
ATE357221T1 (de) | 2007-04-15 |
WO1995028963A1 (fr) | 1995-11-02 |
AU689250B2 (en) | 1998-03-26 |
CN1146158A (zh) | 1997-03-26 |
EP1252896B1 (en) | 2007-03-21 |
US6368629B1 (en) | 2002-04-09 |
DE69528583T2 (de) | 2003-07-10 |
DE69535432T2 (de) | 2007-12-06 |
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