ES2188657T3 - Sistema para la liberacion especifica en el colon de un farmaco. - Google Patents

Sistema para la liberacion especifica en el colon de un farmaco.

Info

Publication number
ES2188657T3
ES2188657T3 ES95916009T ES95916009T ES2188657T3 ES 2188657 T3 ES2188657 T3 ES 2188657T3 ES 95916009 T ES95916009 T ES 95916009T ES 95916009 T ES95916009 T ES 95916009T ES 2188657 T3 ES2188657 T3 ES 2188657T3
Authority
ES
Spain
Prior art keywords
colon
drug
pharmaco
enterobacteria
organic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95916009T
Other languages
English (en)
Inventor
Shunsuke Watanabe
Hitoshi Kawai
Masataka Katsuma
Muneo Fukui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2188657T3 publication Critical patent/ES2188657T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

SISTEMA PARA LIBERAR UN MEDICAMENTO DE FORMA ESPECIFICA EN EL COLON DEL TRACTO GASTROINTESTINAL, QUE INCLUYE UN MEDICAMENTO (B) CUBIERTO CON UN MATERIAL POLIMERICO SOLUBLE EN ACIDO ORGANICO (A) Y UN SACARIDO (C) QUE GENERA RAPIDAMENTE UN ACIDO ORGANICO MEDIANTE LA ACCION DE ENTEROBACTERIAS EN LA PARTE INFERIOR DEL TRACTO GASTROINTESTINAL; PREPARADO ORAL PARA LA LIBERACION DE MEDICACION ESPECIFICA PARA EL COLON, QUE INCLUYE UN COMPUESTO QUE TIENE UN MEDICAMENTO (B) CUBIERTO CON UN MATERIAL POLIMERICO SOLUBLE EN ACIDO ORGANICO (A) Y UN SACARIDO (C) QUE GENERA RAPIDAMENTE UN ACIDO ORGANICO MEDIANTE LA ACCION DE ENTEROBACTERIAS EN LA PARTE INFERIOR DEL TRACTO GASTROINTESTINAL, ESTANDO CUBIERTA ESTA COMPOSICION CON UN MATERIAL POLIMERICO CE COBERTURA ENTERICA (D). LA INVENCION PROPORCIONA UN SISTEMA DE LIBERACION DEL MEDICAMENTO Y UNA PREPARACION QUE UTILIZA ENTEROBACTERIAS, QUE NO DAN LUGAR A SUSTANCIAS DAÑINAS DEBIDO AL MECANISMO DE COMIENZO DE LIBERACION, Y A QUE MUESTRAN UNA RAPIDA DEGRADACION Y TIENEN MAYOR ESPECIFICIDAD PARA EL COLON.
ES95916009T 1994-04-22 1995-04-19 Sistema para la liberacion especifica en el colon de un farmaco. Expired - Lifetime ES2188657T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8511494 1994-04-22

Publications (1)

Publication Number Publication Date
ES2188657T3 true ES2188657T3 (es) 2003-07-01

Family

ID=13849609

Family Applications (2)

Application Number Title Priority Date Filing Date
ES02077556T Expired - Lifetime ES2283503T3 (es) 1994-04-22 1995-04-19 Sistema de liberacion de farmaco especifico de colon.
ES95916009T Expired - Lifetime ES2188657T3 (es) 1994-04-22 1995-04-19 Sistema para la liberacion especifica en el colon de un farmaco.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES02077556T Expired - Lifetime ES2283503T3 (es) 1994-04-22 1995-04-19 Sistema de liberacion de farmaco especifico de colon.

Country Status (12)

Country Link
US (2) US6368629B1 (es)
EP (2) EP1252896B1 (es)
JP (1) JP3867171B2 (es)
KR (1) KR100388569B1 (es)
CN (1) CN1072964C (es)
AT (2) ATE357221T1 (es)
AU (1) AU689250B2 (es)
DE (2) DE69528583T2 (es)
ES (2) ES2283503T3 (es)
RU (1) RU2155605C2 (es)
TW (1) TW422701B (es)
WO (1) WO1995028963A1 (es)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69528583T2 (de) * 1994-04-22 2003-07-10 Yamanouchi Pharma Co Ltd Kolon-spezifisches arzneistofffreisetzungssystem
US5912014A (en) * 1996-03-15 1999-06-15 Unigene Laboratories, Inc. Oral salmon calcitonin pharmaceutical products
US5814308A (en) * 1996-03-26 1998-09-29 Zhang; Ke Methods for the treatment of gastrointestinal tract disorders
US5948892A (en) * 1996-12-16 1999-09-07 Amgen Inc. Analogs of macrophage stimulating protein
AU5775398A (en) * 1996-12-17 1998-07-15 Poli Industria Chimica S.P.A. Site-specific controlled release dosage formulation for mesalamine
DK0955058T3 (da) * 1997-01-09 2004-08-30 Morinaga Milk Industry Co Ltd Lactoferrintabletter
DE19732903A1 (de) 1997-07-30 1999-02-04 Falk Pharma Gmbh Pellet-Formulierung zur Behandlung des Intestinaltraktes
US6099859A (en) * 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
DE69915818T2 (de) * 1998-04-30 2005-01-05 Morinaga Milk Industry Co. Ltd. Zuckerbeschichtete tabletten
WO2000040089A1 (en) * 1999-01-05 2000-07-13 Massachusetts Eye And Ear Infirmary Targeted transscleral controlled release drug delivery to the retina and choroid
US6355270B1 (en) * 1999-01-11 2002-03-12 The Regents Of The University Of California Particles for oral delivery of peptides and proteins
IT1312569B1 (it) * 1999-05-21 2002-04-22 Raffaele Ansovini Uso dell'enzima gssg reduttasi per il trattamento terapeutico e laprofilassi di pazienti infettati da hiv.
EP1184038B1 (en) * 1999-06-09 2005-12-28 Mochida Pharmaceutical Co., Ltd. System for release in lower digestive tract
PT1183014E (pt) 1999-06-14 2003-12-31 Cosmo Spa Composicoes farmaceuticas orais de libertacao controlada e de dissimulacao de sabor
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
EP1197228A4 (en) 1999-07-02 2004-03-10 Hisamitsu Pharmaceutical Co DRUG COMPOSITIONS FOR THE TREATMENT OF COLORECTAL CANCER
DE60035421T2 (de) 1999-08-09 2008-03-13 Dainippon Sumitomo Pharma Co., Ltd. Chitosanpulver enthaltende feste zubereitungen und verfahren zu deren herstellung
JP4524009B2 (ja) * 1999-08-09 2010-08-11 大日本住友製薬株式会社 大腸内放出性カプセル製剤
US7892586B2 (en) 2001-02-22 2011-02-22 Suzanne Jaffe Stillman Water containing soluble fiber
US8178150B2 (en) 2000-02-22 2012-05-15 Suzanne Jaffe Stillman Water containing soluble fiber
WO2001087272A2 (en) * 2000-05-18 2001-11-22 Therics, Inc. Encapsulating a toxic core within a non-toxic region in an oral dosage form
US20050175687A1 (en) * 2001-01-30 2005-08-11 Mcallister Stephen M. Pharmaceutical formulations
US7842308B2 (en) 2001-01-30 2010-11-30 Smithkline Beecham Limited Pharmaceutical formulation
GB0102342D0 (en) * 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
US7883721B2 (en) 2001-01-30 2011-02-08 Smithkline Beecham Limited Pharmaceutical formulation
US7316819B2 (en) * 2001-03-08 2008-01-08 Unigene Laboratories, Inc. Oral peptide pharmaceutical dosage form and method of production
WO2002085415A1 (en) * 2001-04-17 2002-10-31 Biomatrix, Inc Non-digestible sugar-coated products and process
DE60230632D1 (de) 2001-07-18 2009-02-12 Euro Celtique Sa Pharmazeutische kombinationen von oxycodon und naloxon
US20030044458A1 (en) * 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
AU2011205217B2 (en) * 2001-08-06 2013-06-13 Euro-Celtique S.A. Oral dosage form comprising a therapeutic agent and an adverse-effect agent
US7196059B2 (en) * 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
JP2003201256A (ja) * 2001-12-28 2003-07-18 Hisamitsu Pharmaceut Co Inc 大腸送達性経口医薬製剤、大腸癌治療用経口医薬製剤および大腸炎治療用経口医薬製剤
US7923025B2 (en) 2002-01-16 2011-04-12 Astellas Pharma Inc. Pharmaceutical composition for oral use with improved absorption
WO2003092665A2 (en) * 2002-05-02 2003-11-13 Massachusetts Eye And Ear Infirmary Ocular drug delivery systems and use thereof
JP2004075582A (ja) * 2002-08-13 2004-03-11 Takeda Chem Ind Ltd 固形医薬組成物に処方される有効成分以外の成分の安定化方法
DE60330161D1 (de) * 2002-08-29 2009-12-31 Activbiotics Pharma Llc Rifalazil zur behandlung von infektionen mit clostridium difficile
DE10260921A1 (de) * 2002-12-20 2004-07-01 Röhm GmbH & Co. KG Verfahren zum Überziehen von Substraten für pharmazeutische Anwendungen mit einem Gemisch aus zwei filmbildenden Überzugsmitteln
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
WO2004073551A2 (en) * 2003-02-18 2004-09-02 Massachusetts Eye And Ear Infirmary Transscleral drug delivery device and related methods
GB0310919D0 (en) * 2003-05-13 2003-06-18 West Pharm Serv Drug Res Ltd Pharmaceutical compositions
US20050142191A1 (en) * 2003-06-23 2005-06-30 Neurochem (International) Limited Pharmaceutical formulations of amyloid inhibiting compounds
US20060079578A1 (en) * 2003-06-23 2006-04-13 Julie Laurin Pharmaceutical formulations of amyloid inhibiting compounds
TW200526274A (en) 2003-07-21 2005-08-16 Smithkline Beecham Plc Pharmaceutical formulations
US7825106B2 (en) 2003-09-03 2010-11-02 Agi Therapeutics Ltd. Modified release formulations and methods of treating inflammatory bowel disease
US7737133B2 (en) 2003-09-03 2010-06-15 Agi Therapeutics Ltd. Formulations and methods of treating inflammatory bowel disease
US7943179B2 (en) * 2003-09-23 2011-05-17 Massachusetts Institute Of Technology pH triggerable polymeric particles
US20050123596A1 (en) * 2003-09-23 2005-06-09 Kohane Daniel S. pH-triggered microparticles
EP1684733B1 (en) * 2003-11-21 2011-09-21 Commonwealth Scientific And Industrial Research Organisation G i tract delivery systems
US7670624B2 (en) * 2004-01-29 2010-03-02 Astella Pharma Inc. Gastrointestinal-specific multiple drug release system
TW201240679A (en) 2004-03-12 2012-10-16 Capsugel Belgium Nv Pharmaceutical formulations
ES2639839T3 (es) * 2004-04-28 2017-10-30 Commonwealth Scientific And Industrial Research Organisation Proceso de tratamiento del almidón
US7645459B2 (en) 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
US7645460B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of risedronate
US20080287400A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
US20080286359A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
RU2284832C2 (ru) * 2004-08-30 2006-10-10 Николай Александрович Киселев Антимикробная композиция для перорального введения
CA2611586A1 (en) * 2005-04-12 2007-06-21 Neurochem (International) Limited Pharmaceutical formulations of amyloid inhibiting compounds
US20060280795A1 (en) * 2005-06-08 2006-12-14 Dexcel Pharma Technologies, Ltd. Specific time-delayed burst profile delivery system
WO2007038867A1 (en) * 2005-10-04 2007-04-12 Mistral Pharma Inc. Controlled-release oral dosage form
GB0607534D0 (en) * 2006-04-13 2006-05-24 Univ London Pharmacy Colonic drug delivery formulation
WO2008093554A1 (ja) * 2007-01-30 2008-08-07 Olympus Medical Systems Corp. 管腔通過確認装置および管腔通過確認装置の製造方法
CN103120653B (zh) 2007-04-04 2015-09-30 希格默伊德药业有限公司 一种口服药物组合物
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US20090036414A1 (en) * 2007-08-02 2009-02-05 Mutual Pharmaceutical Company, Inc. Mesalamine Formulations
DE102007060175A1 (de) * 2007-12-13 2009-06-18 Johannes Gutenberg-Universität Mainz Quartärnisierung des Zusatzstoffs Aminoalkyl Methacrylat Copolymer E zur Verbesserung der Permeabilität und Löslichkeit von Arzneistoffen
BRPI0822359A2 (pt) 2008-03-18 2015-07-14 Aleksander Vladimirovich Dikovskiy Composição farmacêutica de antibióticos e prebióticos para prevenir e tratar disbiose durante terapia antibacteriana
JP2011519928A (ja) * 2008-05-07 2011-07-14 メリオン・リサーチ・Ｉｉｉ・リミテッド ペプチドの組成物及びその調製方法
US20100074947A1 (en) * 2008-06-13 2010-03-25 Adrian Brown Pharmaceutical Formulations
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
IT1393244B1 (it) * 2008-07-18 2012-04-12 Universita' Degli Studi Di Milano Sistema per il rilascio al colon di farmaci suscettibili di degradazione enzimatica e/o scarsamente assorbiti nel tratto gastrointestinale
NZ598783A (en) 2009-09-18 2013-07-26 Adolor Corp Use of opioid receptor antagonist for gastrointestinal tract disorders
US20110142889A1 (en) * 2009-12-16 2011-06-16 Nod Pharmaceuticals, Inc. Compositions and methods for oral drug delivery
WO2011084618A2 (en) * 2009-12-16 2011-07-14 Nod Pharmaceuticals, Inc. Compositions and methods for oral drug delivery
CN102552919B (zh) * 2010-12-15 2018-03-27 上海安博生物医药股份有限公司 一种给药组合物及其制备和使用方法
HU230560B1 (hu) * 2010-07-30 2016-12-28 Péter Hajnal pH-függő szakaszos és nyújtott hatóanyagleadású gyógyszerkészítmény
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US10653631B2 (en) 2011-09-07 2020-05-19 Roland SAUR-BROSCH Optimal colon targeting technology
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
JP2014529630A (ja) * 2011-09-07 2014-11-13 ザウラー−ブロシュ、ローラント 哺乳類の消化管における一つあるいは複数の物質の放出制御製剤
CN109172816A (zh) 2012-03-29 2019-01-11 塞拉拜姆有限责任公司 在回肠和阑尾上有活性的胃肠位点特异性口服接种疫苗制剂
US20140066837A1 (en) 2012-07-26 2014-03-06 Ronald L. Moy Skin care compositions and methods
CA2902348C (en) 2013-02-25 2021-11-30 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
RU2015140610A (ru) 2013-03-14 2017-04-17 ТЕРАБАЙОМ, ЭлЭлСи Направленная доставка в желудочно-кишечный тракт пробиотических микроорганизмов и/или терапевтических средств
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CN203539304U (zh) * 2013-07-08 2014-04-16 南方医科大学南方医院 一种消化道探路胶囊
EA201690732A1 (ru) 2013-10-10 2016-12-30 Синерджи Фармасьютикалз, Инк. Агонисты гуанилатциклазы, используемые для лечения индуцированных опиоидами дисфункций
US10182993B2 (en) 2015-04-06 2019-01-22 Patheon Softgels Inc. Compositions for colonic delivery of drugs
WO2017123634A1 (en) 2016-01-11 2017-07-20 Synergy Pharmaceuticals, Inc. Formulations and methods for treating ulcerative colitis
TWI730230B (zh) * 2018-05-22 2021-06-11 大陸商合肥合源藥業有限公司 乳果糖糖苷化合物、其製備方法及其用途
US11590161B2 (en) 2018-08-13 2023-02-28 Viscera Labs, Inc. Therapeutic composition and methods
US11524029B2 (en) 2018-08-13 2022-12-13 Viscera Labs, Inc. Therapeutic composition and methods

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1204363B (de) 1963-09-10 1965-11-04 Hoffmann La Roche Verfahren zur Herstellung einer oralen Arzneizubereitung, die ihren Wirkstoff erst im Ileum abgibt
US4863744A (en) * 1984-09-17 1989-09-05 Alza Corporation Intestine drug delivery
JPS6261916A (ja) * 1985-09-12 1987-03-18 Fujisawa Pharmaceut Co Ltd 持続性製剤
US4968508A (en) * 1987-02-27 1990-11-06 Eli Lilly And Company Sustained release matrix
US5068110A (en) * 1987-09-29 1991-11-26 Warner-Lambert Company Stabilization of enteric coated dosage form
IT1246382B (it) * 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
JPH0813748B2 (ja) * 1990-04-23 1996-02-14 帝國製薬株式会社 大腸崩壊性ポリペプチド系経口製剤
MC2288A1 (fr) * 1990-05-04 1993-07-14 Perio Prod Ltd Systeme d'administration de medicament au niveau du colon
IL98087A (en) * 1990-05-04 1996-11-14 Perio Prod Ltd Preparation for dispensing drugs in the colon
JPH064531B2 (ja) * 1990-06-04 1994-01-19 アイセロ化学株式会社 大腸崩壊性硬質カプセル
JP3282832B2 (ja) * 1991-02-19 2002-05-20 帝國製薬株式会社 持続性錠剤
JP2916290B2 (ja) * 1991-03-22 1999-07-05 帝國製薬株式会社 生理活性ポリペプチド含有大腸崩壊経口製剤
US5656290A (en) * 1993-02-26 1997-08-12 The Procter & Gamble Company Bisacodyl dosage form with multiple enteric polymer coatings for colonic delivery
DE69528583T2 (de) * 1994-04-22 2003-07-10 Yamanouchi Pharma Co Ltd Kolon-spezifisches arzneistofffreisetzungssystem
US5656294A (en) * 1995-06-07 1997-08-12 Cibus Pharmaceutical, Inc. Colonic delivery of drugs
US5840332A (en) 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
US5840322A (en) * 1996-12-19 1998-11-24 Ramot-University Authority For Applied Research & Industrial Devel. Ltd. Anti-oral-microbial adhesion fraction derived from vaccinium

Also Published As

Publication number Publication date
CN1072964C (zh) 2001-10-17
EP1252896A2 (en) 2002-10-30
EP1252896A3 (en) 2003-10-08
JP3867171B2 (ja) 2007-01-10
AU2266895A (en) 1995-11-16
RU2155605C2 (ru) 2000-09-10
US6506407B2 (en) 2003-01-14
KR100388569B1 (ko) 2003-10-11
US20020044975A1 (en) 2002-04-18
EP0759303B1 (en) 2002-10-16
ES2283503T3 (es) 2007-11-01
TW422701B (en) 2001-02-21
EP0759303A4 (en) 1998-05-06
DE69535432D1 (de) 2007-05-03
ATE226090T1 (de) 2002-11-15
EP0759303A1 (en) 1997-02-26
DE69528583D1 (de) 2002-11-21
ATE357221T1 (de) 2007-04-15
WO1995028963A1 (fr) 1995-11-02
AU689250B2 (en) 1998-03-26
CN1146158A (zh) 1997-03-26
EP1252896B1 (en) 2007-03-21
US6368629B1 (en) 2002-04-09
DE69528583T2 (de) 2003-07-10
DE69535432T2 (de) 2007-12-06

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