DE69528362D1 - Oligomere phosphoramidat- und phosphorthioamidatverbindungen - Google Patents

Oligomere phosphoramidat- und phosphorthioamidatverbindungen

Info

Publication number
DE69528362D1
DE69528362D1 DE69528362T DE69528362T DE69528362D1 DE 69528362 D1 DE69528362 D1 DE 69528362D1 DE 69528362 T DE69528362 T DE 69528362T DE 69528362 T DE69528362 T DE 69528362T DE 69528362 D1 DE69528362 D1 DE 69528362D1
Authority
DE
Germany
Prior art keywords
groups
compounds
phosphorthioamidate
phosphoramidate
oligomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69528362T
Other languages
English (en)
Inventor
Phillip Dan Cook
Oscar Acevedo
Normand Hebert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69528362D1 publication Critical patent/DE69528362D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Luminescent Compositions (AREA)
DE69528362T 1994-02-23 1995-02-23 Oligomere phosphoramidat- und phosphorthioamidatverbindungen Expired - Lifetime DE69528362D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/200,638 US5637684A (en) 1994-02-23 1994-02-23 Phosphoramidate and phosphorothioamidate oligomeric compounds
PCT/US1995/002267 WO1995023160A1 (en) 1994-02-23 1995-02-23 Novel phosphoramidate and phophorothioamidate oligomeric compounds

Publications (1)

Publication Number Publication Date
DE69528362D1 true DE69528362D1 (de) 2002-10-31

Family

ID=22742548

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69528362T Expired - Lifetime DE69528362D1 (de) 1994-02-23 1995-02-23 Oligomere phosphoramidat- und phosphorthioamidatverbindungen

Country Status (8)

Country Link
US (2) US5637684A (de)
EP (1) EP0751948B1 (de)
JP (1) JP2972344B2 (de)
AT (1) ATE224908T1 (de)
AU (1) AU677150B2 (de)
CA (1) CA2184005C (de)
DE (1) DE69528362D1 (de)
WO (1) WO1995023160A1 (de)

Families Citing this family (339)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962219A (en) * 1990-06-11 1999-10-05 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-selex
US5919965A (en) * 1995-01-18 1999-07-06 Genzyme Corporation Non-nucleotide phosphorus ester oligomers
US5969135A (en) * 1995-11-02 1999-10-19 Icn Pharmaceuticals, Inc. Oligonucleotide analogs with an amino acid or a modified amino alcohol residue
WO1997028168A1 (en) * 1996-02-01 1997-08-07 Pharmagenics, Inc. Non-nucleotide phosphorous ester oligomers
US6489093B1 (en) 1996-09-20 2002-12-03 President And Fellows Of Harvard College Combinatorial approach for generating novel coordination complexes
US5908845A (en) * 1996-10-30 1999-06-01 Segev; David Polyether nucleic acids
WO1998021226A1 (fr) * 1996-11-13 1998-05-22 Chugai Seiyaku Kabushiki Kaisha Derive oligonucleotidique h-phosphonate et procede de production associe
US5789333A (en) * 1997-03-05 1998-08-04 Iowa State University Research Foundation, Inc. Catalyst system comprising a first catalyst system tethered to a supported catalyst
US7252950B1 (en) * 1997-09-04 2007-08-07 The Regents Of The University Of California Assays for detecting modulators of cytoskeletal function
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
AU2107199A (en) 1998-01-08 1999-07-26 Regents Of The University Of California, The Kinesin motor modulators derived from the marine sponge (adocia)
US6764830B1 (en) 1998-01-23 2004-07-20 The Regents Of The University Of California Thermomyces lanuginosus kinesin motor protein and methods of screening for modulators of kinesin proteins
DE69940430D1 (de) 1998-06-24 2009-04-02 Illumina Inc Dekodierung von matrixartig-angeordneten Sensoren durch Mikropartikel
US20020172678A1 (en) 2000-06-23 2002-11-21 Napoleone Ferrara EG-VEGF nucleic acids and polypeptides and methods of use
US6492111B1 (en) 1998-11-25 2002-12-10 Isis Pharmaceuticals, Inc. In situ binary synthesis of biologically effective molecules
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
WO2000058472A2 (en) 1999-03-31 2000-10-05 The University Of North Carolina At Chapel Hill Isolated dna encoding cullin regulators roc1 and roc2, isolated proteins encoded by the same, and methods utilizing the same
EP1923471B1 (de) 1999-04-20 2012-12-19 Illumina, Inc. Erkennung von Nukleinsäurereaktionen auf Bead-Arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
EP2360270B1 (de) 1999-05-20 2016-11-09 Illumina, Inc. Kombinatorische Entschlüsselung von Zufallsnukleinsäurearrays
PT1210357E (pt) 1999-09-10 2008-06-11 Geron Corp Oligonucleótido-tiofosforamidatos n3'→p5': sua síntese e utilização
AU2001238389B2 (en) 2000-02-16 2006-09-21 Illumina, Inc. Parallel genotyping of multiple patient samples
IL151348A0 (en) * 2000-04-13 2003-04-10 Univ Rockefeller Enhancement of antibody-mediated immune responses
DE10041539A1 (de) * 2000-08-24 2002-03-07 Febit Ferrarius Biotech Gmbh Neue Amiditderivate zur Synthese von Polymeren auf Oberflächen
WO2002022649A2 (en) * 2000-09-14 2002-03-21 Mount Sinai School Of Medicine Screening methods to identify g-proteins and other compounds which modulate phosphodiesterase (pde) activity
US20030044803A1 (en) * 2000-09-22 2003-03-06 Pedersen Finn Skou Methods for diagnosis and treatment of diseases associated with altered expression of JAK1
US20020115058A1 (en) * 2000-09-22 2002-08-22 Pedersen Finn Skou Methods for diagnosis and treatment of diseases associated with altered expression of Pik3r1
US20030077590A1 (en) * 2000-09-22 2003-04-24 Pedersen Finn Skou Methods for diagnosis and treatment of diseases associated with altered expression of neurogranin
US7045283B2 (en) 2000-10-18 2006-05-16 The Regents Of The University Of California Methods of high-throughput screening for internalizing antibodies
EP1736760A3 (de) 2000-12-11 2008-06-18 President And Fellows Of Harvard College Nanosensoren
US20030099963A1 (en) * 2000-12-22 2003-05-29 Morris David W. Novel compositions and methods in cancer associated with altered expression of TBX21
US7700274B2 (en) * 2000-12-22 2010-04-20 Sagres Discovery, Inc. Compositions and methods in cancer associated with altered expression of KCNJ9
US7645441B2 (en) * 2000-12-22 2010-01-12 Sagres Discovery Inc. Compositions and methods in cancer associated with altered expression of PRLR
US20030232334A1 (en) * 2000-12-22 2003-12-18 Morris David W. Novel compositions and methods for cancer
US20030087252A1 (en) * 2000-12-22 2003-05-08 Morris David W. Novel compositions and methods in cancer associated with altered expression of PRDM11
US20030165878A1 (en) * 2000-12-22 2003-09-04 Morris David W. Novel compositions and methods in cancer associated with altered expression of MCM3AP
US7820447B2 (en) 2000-12-22 2010-10-26 Sagres Discovery Inc. Compositions and methods for cancer
US7892730B2 (en) * 2000-12-22 2011-02-22 Sagres Discovery, Inc. Compositions and methods for cancer
US20030036854A1 (en) * 2001-02-06 2003-02-20 The Penn State Research Foundation Apparatus and method for designing proteins and protein libraries
WO2002086079A2 (en) * 2001-04-20 2002-10-31 Mount Sinai School Of Medicine T1r3 a novel taste receptor
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
US6534646B2 (en) * 2001-06-04 2003-03-18 Barrskogen, Inc. Oligonucleotide labeling reagents
ATE441857T1 (de) 2001-07-10 2009-09-15 Univ Leland Stanford Junior Verfahren und zusammensetzungen zum nachweis des aktivierungszustands multipler proteine in einzelzellen
US7381535B2 (en) 2002-07-10 2008-06-03 The Board Of Trustees Of The Leland Stanford Junior Methods and compositions for detecting receptor-ligand interactions in single cells
US7393656B2 (en) * 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
WO2003006677A2 (en) 2001-07-12 2003-01-23 Illumina, Inc. Multiplex nucleic acid reactions
AU2002322458A1 (en) * 2001-07-13 2003-01-29 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
CA2563510A1 (en) * 2001-07-13 2005-11-17 Nanosphere, Inc. Method for preparing substrates having immobilized molecules and substrates
US7297553B2 (en) 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
EP1427821B1 (de) * 2001-08-20 2007-06-20 Regenesis Bioremediation Products Biosensor für kleinmolekulare analyten
US20070098728A1 (en) * 2001-09-24 2007-05-03 Pedersen Finn S Novel compositions and methods in cancer
CA2495529C (en) 2001-10-01 2009-05-19 Mount Sinai School Of Medicine Of New York University Noonan syndrome gene
US20040126762A1 (en) * 2002-12-17 2004-07-01 Morris David W. Novel compositions and methods in cancer
US20040166490A1 (en) * 2002-12-17 2004-08-26 Morris David W. Novel therapeutic targets in cancer
ES2491867T3 (es) 2001-10-26 2014-09-08 Danisco Us Inc. Enzimas fitasa, secuencias de ácido nucleico que codifican enzimas fitasa y vectores y células huésped que incorporan las mismas
AU2002334950A1 (en) * 2001-10-26 2003-05-12 Genencor International, Inc. T. reesei phytase enzymes, polynucleides encoding the enzymes, vectors and host cells thereof, and methods of using
US20040197778A1 (en) * 2002-12-26 2004-10-07 Sagres Discovery, Inc. Novel compositions and methods in cancer
US20040180344A1 (en) * 2003-03-14 2004-09-16 Morris David W. Novel therapeutic targets in cancer
US20060040262A1 (en) * 2002-12-27 2006-02-23 Morris David W Novel compositions and methods in cancer
EP1474432A1 (de) * 2002-02-04 2004-11-10 Biomira Inc. Immunstimulierende, kovalent lipid-modifizierte oligonukleotide
AU2003215240A1 (en) * 2002-02-14 2003-09-04 Illumina, Inc. Automated information processing in randomly ordered arrays
ATE431406T1 (de) 2002-02-25 2009-05-15 Genentech Inc Neuer typ-1-cytokinrezeptor glm-r
CA2479730A1 (en) 2002-03-21 2003-10-02 Sagres Discovery, Inc. Novel compositions and methods in cancer
US7332585B2 (en) 2002-04-05 2008-02-19 The Regents Of The California University Bispecific single chain Fv antibody molecules and methods of use thereof
CA2483489C (en) 2002-04-26 2015-12-08 University Of Utah Research Foundation Characterization of single stranded nucleic acids by melting analysis of secondary structure using double strand-specific nucleic acid dye
US20030220844A1 (en) * 2002-05-24 2003-11-27 Marnellos Georgios E. Method and system for purchasing genetic data
US20060183106A1 (en) * 2002-10-18 2006-08-17 Adam Siddiqui-Jain Processes for identifying quadruplex-targeted antiviral molecules
AU2013202894B2 (en) * 2002-10-25 2014-09-25 Honeywell International, Inc. Compositions containing flourine substituted olefins
EP2112229A3 (de) 2002-11-25 2009-12-02 Sequenom, Inc. Verfahren zum Identifizieren des Brustkrebsrisikos und zugehörige Behandlungen
EP3351919A1 (de) 2003-01-24 2018-07-25 University of Utah Verfahren zur vorhersage des sterblichkeitsrisikos mittels bestimmung der telomerlänge
US7767387B2 (en) * 2003-06-13 2010-08-03 Sagres Discovery, Inc. Therapeutic targets in cancer
US20040170982A1 (en) * 2003-02-14 2004-09-02 Morris David W. Novel therapeutic targets in cancer
EP2058408A3 (de) 2003-02-14 2009-09-09 Sagres Discovery, Inc. Therapeutische GPCR-Targets für Karzinome
US20070218071A1 (en) * 2003-09-15 2007-09-20 Morris David W Novel therapeutic targets in cancer
WO2004087931A1 (en) * 2003-04-03 2004-10-14 Korea Advanced Institute Of Science And Technology Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof
EP1618199A2 (de) * 2003-04-10 2006-01-25 Aristex Affinitätsreinigungsverfahren durch troponinmoleküle als affinitätsliganden
US20050025763A1 (en) 2003-05-08 2005-02-03 Protein Design Laboratories, Inc. Therapeutic use of anti-CS1 antibodies
US7709610B2 (en) 2003-05-08 2010-05-04 Facet Biotech Corporation Therapeutic use of anti-CS1 antibodies
WO2004106360A2 (en) * 2003-05-23 2004-12-09 Mount Sinai School Of Medicine Of New York University Viral vectors with improved properties
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US7572581B2 (en) * 2003-06-30 2009-08-11 Roche Molecular Systems, Inc. 2′-terminator nucleotide-related methods and systems
US7947817B2 (en) * 2003-06-30 2011-05-24 Roche Molecular Systems, Inc. Synthesis and compositions of 2'-terminator nucleotides
WO2005074417A2 (en) * 2003-09-03 2005-08-18 Salk Institute For Biological Studies Multiple antigen detection assays and reagents
US20070281896A1 (en) * 2003-09-30 2007-12-06 Morris David W Novel compositions and methods in cancer
US7259258B2 (en) * 2003-12-17 2007-08-21 Illumina, Inc. Methods of attaching biological compounds to solid supports using triazine
US20050136414A1 (en) * 2003-12-23 2005-06-23 Kevin Gunderson Methods and compositions for making locus-specific arrays
US7481997B1 (en) 2004-02-12 2009-01-27 Montana State University Snow mountain virus genome sequence, virus-like particles and methods of use
US20050266432A1 (en) * 2004-02-26 2005-12-01 Illumina, Inc. Haplotype markers for diagnosing susceptibility to immunological conditions
AU2005245996A1 (en) 2004-05-21 2005-12-01 Atonomics A/S Surface acoustic wave sensor comprising a hydrogel
US7745125B2 (en) * 2004-06-28 2010-06-29 Roche Molecular Systems, Inc. 2′-terminator related pyrophosphorolysis activated polymerization
US20060024677A1 (en) 2004-07-20 2006-02-02 Morris David W Novel therapeutic targets in cancer
US20060275792A1 (en) * 2004-11-15 2006-12-07 Lee Jun E Enhancement of nucleic acid amplification using double-stranded DNA binding proteins
US20060105348A1 (en) * 2004-11-15 2006-05-18 Lee Jun E Compositions and methods for the detection and discrimination of nucleic acids
US7842794B2 (en) 2004-12-17 2010-11-30 Roche Molecular Systems, Inc. Reagents and methods for detecting Neisseria gonorrhoeae
WO2006069677A2 (en) * 2004-12-30 2006-07-06 Cinvention Ag Combination comprising an agent providing a signal, an implant material and a drug
DE102004063599B4 (de) * 2004-12-30 2007-07-12 Bayer Innovation Gmbh Verkürzte Wundheilungsprozesse mittels neuartiger Faservliese
ATE412691T1 (de) * 2005-01-13 2008-11-15 Cinv Ag Kohlenstoffnanopartikel enthaltende verbundwerkstoffe
EP1841520A1 (de) * 2005-01-24 2007-10-10 Cinvention Ag Metall mit verbundwerkstoffen
MX2007011388A (es) * 2005-03-18 2007-11-13 Cinv Ag Proceso para la preparacion de materiales metalicos sinterizados porosos.
EP2463386B1 (de) 2005-06-15 2017-04-12 Complete Genomics Inc. Nukleinsäureanalyse durch zufällige Mischungen von sich überlappenden Fragmenten
US7465561B2 (en) 2005-06-30 2008-12-16 Roche Molecular Systems, Inc. Probes and methods for hepatitis C virus typing using single probe analysis
AU2006265196A1 (en) * 2005-07-01 2007-01-11 Cinvention Ag Medical devices comprising a reticulated composite material
AU2006265193A1 (en) * 2005-07-01 2007-01-11 Cinvention Ag Process for the production of porous reticulated composite materials
AU2006303324A1 (en) * 2005-10-18 2007-04-26 Cinvention Ag Thermoset particles and methods for production thereof
EP3061834B1 (de) 2005-10-21 2020-01-08 The Regents of the University of California Shp-2 genmutationen bei melanom
US20090291437A1 (en) * 2005-11-02 2009-11-26 O'brien Sean Methods for targeting quadruplex sequences
JP2009523739A (ja) 2006-01-20 2009-06-25 ウィメンズ アンド チルドレンズ ヘルス リサーチ インスティテュート インコーポレーティッド 骨の病変の処置、予防、および診断の方法
SG170028A1 (en) * 2006-02-24 2011-04-29 Callida Genomics Inc High throughput genome sequencing on dna arrays
EP2495337A1 (de) 2006-02-24 2012-09-05 Callida Genomics, Inc. Genomsequenzierung auf DNA-Arrays mit hohem Durchsatz
US7914988B1 (en) 2006-03-31 2011-03-29 Illumina, Inc. Gene expression profiles to predict relapse of prostate cancer
JP2009536525A (ja) * 2006-05-10 2009-10-15 ディクステリティー ダイアグノーティクス 化学反応性オリゴヌクレオチドプローブを使用した核酸標的の検出
US20080063637A1 (en) * 2006-05-19 2008-03-13 The Trustees Of Tufts College Regulation of oncogenesis by Akt-specific isoforms
US20100196336A1 (en) 2006-05-23 2010-08-05 Dongsu Park Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods
EP2029775B1 (de) 2006-06-05 2014-10-15 California Institute Of Technology Echtzeit-mikroarrays
US8637436B2 (en) 2006-08-24 2014-01-28 California Institute Of Technology Integrated semiconductor bioarray
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
US20100190697A1 (en) 2006-09-13 2010-07-29 The Trustees Of Columbia University In The City If Undercarboxylated/uncarboxylated osteocalcin increases beta-cell proliferation, insulin secretion, insulin sensitivity, glucose tolerance and decreases fat mass
AU2007333001A1 (en) 2006-09-14 2008-06-19 The Regents Of The University Of Californina Nanoplasmonic molecular ruler for nuclease activity and DNA footprinting
EP1914303A1 (de) * 2006-10-09 2008-04-23 Qiagen GmbH Thermus eggertssonii DNA Polymerasen
WO2008070352A2 (en) 2006-10-27 2008-06-12 Complete Genomics, Inc. Efficient arrays of amplified polynucleotides
WO2008070375A2 (en) * 2006-11-09 2008-06-12 Complete Genomics, Inc. Selection of dna adaptor orientation
US20080242560A1 (en) * 2006-11-21 2008-10-02 Gunderson Kevin L Methods for generating amplified nucleic acid arrays
US9938641B2 (en) * 2006-12-18 2018-04-10 Fluidigm Corporation Selection of aptamers based on geometry
US7858772B2 (en) * 2006-12-22 2010-12-28 Roche Molecular Systems, Inc. Compounds and methods for synthesis and purification of oligonucleotides
US20080213611A1 (en) * 2007-01-19 2008-09-04 Cinvention Ag Porous, non-degradable implant made by powder molding
CN101646762A (zh) * 2007-02-28 2010-02-10 金文申有限公司 带有增加表面积之基底的高表面积培养系统
EP2126040A1 (de) * 2007-02-28 2009-12-02 Cinvention Ag Kultivierungssystem mit grosser oberfläche
US20080206734A1 (en) * 2007-02-28 2008-08-28 Cinvention Ag High surface cultivation system with filler
US20080206862A1 (en) * 2007-02-28 2008-08-28 Cinvention Ag High surface cultivation system bag
US20090136932A1 (en) * 2007-03-16 2009-05-28 Craighead Harold G Fibers with isolated biomolecules and uses thereof
WO2008141799A1 (en) * 2007-05-24 2008-11-27 Roche Diagnostics Gmbh Oligophosphoramidates
US8097422B2 (en) 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
CN101802182A (zh) 2007-08-21 2010-08-11 诺达利蒂公司 用于诊断、预后和治疗方法的方法
CA2699394C (en) 2007-09-17 2020-03-24 The Regents Of The University Of California Internalizing human monoclonal antibodies targeting prostate cancer cells in situ
WO2009061941A2 (en) 2007-11-06 2009-05-14 Osmetech Molecular Diagnostics Baseless nucleotide analogues and uses thereof
DK2565279T3 (en) 2007-12-05 2015-02-16 Complete Genomics Inc Efficient base determination in sequencing reactions
EP2559766B1 (de) 2007-12-13 2017-10-18 Philip Morris Products S.A. Für reduzierten Cadmiumtransport modifizierte Pflanzen, abgeleitete Produkte und damit verbundene Verfahren
EP3360972B1 (de) 2008-01-17 2019-12-11 Sequenom, Inc. Einzelmolekülnukleinsäurensequenzanalyseverfahren
WO2009114543A2 (en) * 2008-03-11 2009-09-17 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
US10150990B2 (en) 2008-04-21 2018-12-11 Roche Molecular Systems, Inc. Ribonucleotide tag nucleic acid detection
EP2288923A2 (de) 2008-05-21 2011-03-02 Kinemed, Inc. Zusammensetzungen und behandlungsverfahren mit modulatoren von motoneuron-krankheiten
EP2304436A1 (de) 2008-07-10 2011-04-06 Nodality, Inc. Diagnose-, prognose- und behandlungsverfahren
EP2338051B1 (de) 2008-07-17 2013-11-20 IKFE Institut für klinische Forschung und Entwicklung GmbH Biomarker für kardiodiabetes
US8329647B2 (en) 2008-07-17 2012-12-11 Ikfe Institut Fur Klinische Forschung Und Entwicklung Gmbh Method of treating a subject according to biomarkers for insulin resistance
ES2561426T3 (es) 2008-09-03 2016-02-26 Quantumdx Group Limited Diseño, síntesis y uso de nucleótidos sintéticos que comprenden grupos informadores iónicos
JP2012501642A (ja) 2008-09-03 2012-01-26 クワンタムディーエックス・グループ・リミテッド バイオセンサを用いる核酸検出のための検知方策および方法
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US9127312B2 (en) 2011-02-09 2015-09-08 Bio-Rad Laboratories, Inc. Analysis of nucleic acids
EP2342334A4 (de) 2008-09-29 2012-03-14 Univ Pennsylvania Auf tumorgefässmarker gerichtete impfstoffe
DE102008043277A1 (de) * 2008-10-29 2010-05-06 Biotronik Vi Patent Ag Implantat aus einer biokorrodierbaren Eisen- oder Magnesiumlegierung
US8309306B2 (en) * 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
EP2370450A1 (de) 2008-11-27 2011-10-05 Roche Diagnostics GmbH Gezielte synthese von oligophosphoramidatstereoisomeren
AU2009323767A1 (en) 2008-12-04 2011-07-21 IKFE Instituit fur klinische Forschung und Entwicklung GmbH Biomarkers for atherosclerosis
US20110118134A1 (en) 2008-12-11 2011-05-19 Ikfe Gmbh Biomarkers for insulin sensitizer drug response
AU2009329987B2 (en) 2008-12-22 2016-08-04 University Of Utah Research Foundation Monochrome multiplex quantitative PCR
EP2382467A1 (de) 2008-12-30 2011-11-02 IKFE GmbH Biomarker für fettgewebeaktivität
US8206929B2 (en) 2009-01-07 2012-06-26 Roche Molecular Systems, Inc. Nucleic acid amplification with allele-specific suppression of sequence variants
US20100210541A1 (en) 2009-01-07 2010-08-19 Andreas Pfuetzner Biomarkers for Appetite Regulation
WO2010087994A2 (en) 2009-01-30 2010-08-05 Whitehead Institute For Biomedical Research Methods for ligation and uses thereof
US20100233733A1 (en) * 2009-02-10 2010-09-16 Nodality, Inc., A Delaware Corporation Multiple mechanisms for modulation of the pi3 kinase pathway
EP2414544B1 (de) * 2009-04-01 2014-04-23 DXTerity Diagnostics Incorporated Chemische ligationsabhängige sondenamplifizierung (clpa)
US20100297127A1 (en) 2009-04-08 2010-11-25 Ghilardi Nico P Use of il-27 antagonists to treat lupus
US8871494B2 (en) 2009-04-24 2014-10-28 Wisconsin Alumni Research Foundation Over-production of secondary metabolites by over-expression of the VEA gene
US20100279882A1 (en) * 2009-05-01 2010-11-04 Mostafa Ronaghi Sequencing methods
DK2977455T3 (da) 2009-06-15 2020-07-13 Complete Genomics Inc Fremgangsmåde til langfragmentaflæsnings-sekventering
WO2011011630A2 (en) 2009-07-23 2011-01-27 Codexis, Inc. Nitrilase biocatalysts
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
EP2462238B1 (de) 2009-08-07 2013-07-17 Ohmx Corporation Enzyme-gesteuerter redox-ändernder chemischer eliminierungs- (e-trace-) immunassay
US9624522B2 (en) 2009-08-07 2017-04-18 Ohmx Corporation Single, direct detection of hemoglobin A1c percentage using enzyme triggered redox altering chemical elimination (e-trace) immunoassay
US8409802B2 (en) 2009-08-14 2013-04-02 Roche Molecular Systems, Inc. Format of probes to detect nucleic acid differences
US9459246B2 (en) 2009-09-08 2016-10-04 Nodality, Inc. Induced intercellular communication
CN102858995B (zh) 2009-09-10 2016-10-26 森特瑞隆技术控股公司 靶向测序方法
US10174368B2 (en) 2009-09-10 2019-01-08 Centrillion Technology Holdings Corporation Methods and systems for sequencing long nucleic acids
WO2011038228A1 (en) 2009-09-24 2011-03-31 President And Fellows Of Harvard College Bent nanowires and related probing of species
US8394948B2 (en) * 2009-09-30 2013-03-12 Glen Research Corporation Reagents utilizing a serinol scaffold for labeling synthetic oligonucleotides
MX2012004905A (es) 2009-10-30 2012-07-23 Univ British Columbia Mutaciones gna11 en melanoma.
US8614071B2 (en) 2009-12-11 2013-12-24 Roche Molecular Systems, Inc. Preferential amplification of mRNA over DNA using chemically modified primers
CA2785020C (en) 2009-12-22 2020-08-25 Sequenom, Inc. Processes and kits for identifying aneuploidy
CN202823394U (zh) 2010-01-19 2013-03-27 伊鲁米那股份有限公司 用于处理化学反应的设备和系统
EP2525808A2 (de) 2010-01-19 2012-11-28 The Trustees Of Columbia University In The City Of New York Osteocalcin als behandlungsmittel für männliche fortpflanzungsstörungen
US9885088B2 (en) 2010-02-24 2018-02-06 The Broad Institute, Inc. Rapid phenotypic diagnosis of pathogens and drug resistance using transcriptional expression signatures
WO2011133931A1 (en) 2010-04-22 2011-10-27 Genentech, Inc. Use of il-27 antagonists for treating inflammatory bowel disease
EP2567213B1 (de) 2010-05-05 2018-01-24 The Governing Council of the Universtiy of Toronto Verfahren zur verarbeitung getrockneter proben mithilfe einer digitalen mikrofluidischen vorrichtung
WO2011143511A2 (en) 2010-05-12 2011-11-17 Columbia University Methods for producing enteroendocrine cells that make and secrete insulin
US9228240B2 (en) 2010-06-03 2016-01-05 California Institute Of Technology Methods for detecting and quantifying viable bacterial endo-spores
WO2012021749A1 (en) 2010-08-11 2012-02-16 Celula, Inc. Genotyping dna
CA2810520C (en) 2010-09-10 2019-03-12 Bio-Rad Laboratories, Inc. Size selection of dna for chromatin analysis
US8483969B2 (en) 2010-09-17 2013-07-09 Illuminia, Inc. Variation analysis for multiple templates on a solid support
US8753816B2 (en) 2010-10-26 2014-06-17 Illumina, Inc. Sequencing methods
EP2635679B1 (de) 2010-11-05 2017-04-19 Illumina, Inc. Verknüpfung von sequenzstücken mit gepaarten code-tags
EP3536695A1 (de) 2010-12-13 2019-09-11 QuiaPEG Pharmaceuticals AB Funktionalisierte polymere
EP2663639B1 (de) 2011-01-14 2017-09-13 Life Technologies Corporation Verfahren zur isolierung, identifikation und quantifizierung von mirnas
WO2012100078A1 (en) 2011-01-19 2012-07-26 Ohmx Corporation Enzyme triggered redox altering chemical elimination (e-trace) immmunoassay
AU2012211081B2 (en) 2011-01-28 2016-02-04 Illumina, Inc. Oligonucleotide replacement for di-tagged and directional libraries
WO2012106081A2 (en) 2011-01-31 2012-08-09 Illumina, Inc. Methods for reducing nucleic acid damage
US20120208193A1 (en) 2011-02-15 2012-08-16 Bio-Rad Laboratories, Inc. Detecting methylation in a subpopulation of genomic dna
US20120252682A1 (en) 2011-04-01 2012-10-04 Maples Corporate Services Limited Methods and systems for sequencing nucleic acids
AU2012249759A1 (en) 2011-04-25 2013-11-07 Bio-Rad Laboratories, Inc. Methods and compositions for nucleic acid analysis
EP3378954B1 (de) 2011-04-29 2021-02-17 Sequenom, Inc. Quantifizierung einer minderheitsvariante einer nukleinsäure
KR101968778B1 (ko) 2011-05-13 2019-04-12 더 리전트 오브 더 유니버시티 오브 캘리포니아 세포의 선택적 트랜스펙션을 위한 광열 기판
CN106434871B (zh) 2011-05-17 2020-08-18 德克斯特里蒂诊断公司 用于检测目标核酸的方法与组合物
WO2013019960A1 (en) 2011-08-03 2013-02-07 Bio-Rad Laboratories, Inc. Filtering small nucleic acids using permeabilized cells
CN107267615A (zh) 2011-09-23 2017-10-20 霍夫曼-拉罗奇有限公司 G形夹用于改进的等位基因特异性pcr的用途
CA2851356A1 (en) 2011-10-14 2013-04-18 Becton Dickinson And Company Square wave thermal cycling
SG10201510189WA (en) 2011-10-19 2016-01-28 Nugen Technologies Inc Compositions And Methods For Directional Nucleic Acid Amplification And Sequencing
ES2791830T3 (es) 2011-10-28 2020-11-06 Univ California Mutaciones de FLT3 asociadas a resistencia a fármacos en pacientes con aml que tienen mutaciones activadoras en FLT3
US10837879B2 (en) 2011-11-02 2020-11-17 Complete Genomics, Inc. Treatment for stabilizing nucleic acid arrays
CA2854459A1 (en) 2011-11-04 2013-05-10 Ohmx Corporation Novel chemistry used in biosensors
CA2895077A1 (en) 2011-12-12 2013-06-20 Beverly Packard In vivo delivery of oligonucleotides
WO2013096455A1 (en) 2011-12-20 2013-06-27 Dana-Farber Cancer Institute, Inc. Methods for diagnosing and treating oncogenic kras-associated cancer
US9115394B2 (en) 2011-12-22 2015-08-25 Roche Molecular Systems, Inc. Methods and reagents for reducing non-specific amplification
WO2013101783A2 (en) 2011-12-30 2013-07-04 Bio-Rad Laboratories, Inc. Methods and compositions for performing nucleic acid amplification reactions
WO2013106434A1 (en) 2012-01-09 2013-07-18 Ohmx Corporation Enzyme cascade methods for e-trace assay signal amplification
EP4372084A3 (de) 2012-01-26 2024-08-14 Tecan Genomics, Inc. Zusammensetzungen und verfahren zur gezielten nukleinsäuresequenzanreicherung und hocheffizienten erzeugung einer bibliothek
US9862994B2 (en) 2012-02-09 2018-01-09 Dana-Farber Cancer Institute, Inc. Selective nucleic acid amplification from nucleic acid pools
EP3757210B1 (de) 2012-03-02 2022-08-24 Sequenom, Inc. Verfahren zur anreicherung von krebsnukleinsäure aus einer biologischen probe
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US9359616B2 (en) 2012-05-21 2016-06-07 The Scripps Research Institute Ribosomal polynucleotides and related expression systems
EP2855698A4 (de) 2012-05-24 2016-03-30 Dana Farber Cancer Inst Inc Abzielung auf den glutamin-zu-pyruvat-signalweg zur behandlung von mit dem kras-onkogen assoziierten krebs
EP3628332A1 (de) 2012-06-12 2020-04-01 QuiaPEG Pharmaceuticals AB Konjugate biologisch aktiver moleküle an funktionalisierte polymere
CN104619894B (zh) 2012-06-18 2017-06-06 纽亘技术公司 用于非期望核酸序列的阴性选择的组合物和方法
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
CA2878979C (en) 2012-07-13 2021-09-14 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
WO2014014518A1 (en) 2012-07-18 2014-01-23 Dana-Farber Cancer Institute, Inc. Methods for treating, preventing and predicting risk of developing breast cancer
EP4071253A1 (de) 2012-07-26 2022-10-12 Illumina, Inc. Zusammensetzungen und verfahren zur amplifikation von nukleinsäuren
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
JP1628116S (de) 2012-10-24 2019-04-01
US11060145B2 (en) 2013-03-13 2021-07-13 Sequenom, Inc. Methods and compositions for identifying presence or absence of hypermethylation or hypomethylation locus
WO2014142850A1 (en) 2013-03-13 2014-09-18 Illumina, Inc. Methods and compositions for nucleic acid sequencing
US10324011B2 (en) 2013-03-15 2019-06-18 The Trustees Of Princeton University Methods and devices for high throughput purification
EP3034171B1 (de) 2013-03-15 2019-04-24 Genmark Diagnostics Inc. Systeme, verfahren und vorrichtung zur manipulation verformbarer flüssigkeitsgefässe
US9822408B2 (en) 2013-03-15 2017-11-21 Nugen Technologies, Inc. Sequential sequencing
AU2014232869A1 (en) 2013-03-15 2015-10-08 Patrizia Fanara Methods for monitoring the effects of an agent in sujects with motoneuron disease with dementia
US11493428B2 (en) 2013-03-15 2022-11-08 Gpb Scientific, Inc. On-chip microfluidic processing of particles
US10052364B2 (en) 2013-03-15 2018-08-21 The Trustees Of Columbia University In The City Of New York Osteocalcin as a treatment for cognitive disorders
WO2014152054A1 (en) 2013-03-15 2014-09-25 Bio-Rad Laboratories, Inc. Digital assays for mutation detection
JP6546158B2 (ja) 2013-05-22 2019-07-17 テロメア ダイアグノスティクス インコーポレイテッド 短いテロメアの存在量の測定
WO2015013681A1 (en) 2013-07-25 2015-01-29 Bio-Rad Laboratories, Inc. Genetic assays
US10782295B2 (en) 2013-08-13 2020-09-22 The Scripps Research Institute Cysteine-reactive ligand discovery in proteomes
RU2016117978A (ru) 2013-10-11 2017-11-17 Дженентек, Инк. Ингибиторы nsp4 и способы их применения
JP6640079B2 (ja) 2013-10-16 2020-02-05 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア 小容積の粒子を調製するためのデバイス及び方法
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US10351918B2 (en) 2013-10-30 2019-07-16 Green Life Biotech, Llc Pathogenesis quantification systems and treatment methods for citrus greening blight
JP6525473B2 (ja) 2013-11-13 2019-06-05 ニューゲン テクノロジーズ， インコーポレイテッド 複製物配列決定リードを同定するための組成物および方法
CA2926871C (en) 2013-11-26 2022-08-16 Illumina, Inc. Compositions and methods for polynucleotide sequencing
EP3077543B1 (de) 2013-12-05 2019-09-25 Centrillion Technology Holdings Corporation Herstellung von gemusterten anordnungen
CN105940024B (zh) 2013-12-05 2019-03-15 生捷科技控股公司 修饰的表面
WO2015085274A1 (en) 2013-12-05 2015-06-11 Centrillion Technology Holdings Corporation Methods for sequencing nucleic acids
US9243289B2 (en) 2013-12-23 2016-01-26 Roche Molecular Systems, Inc. Method for screening reagents used in PCR assays
CA2935720A1 (en) 2014-01-16 2015-07-23 Illumina, Inc. Gene expression panel for prognosis of prostate cancer recurrence
US9745614B2 (en) 2014-02-28 2017-08-29 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
WO2015138774A1 (en) 2014-03-13 2015-09-17 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2015149006A2 (en) 2014-03-27 2015-10-01 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating ncoa4-mediated autophagic targeting of ferritin
WO2015149016A2 (en) 2014-03-28 2015-10-01 University Of Washington Through Its Center For Commercialization Breast and ovarian cancer vaccines
US11060139B2 (en) 2014-03-28 2021-07-13 Centrillion Technology Holdings Corporation Methods for sequencing nucleic acids
JP6574239B2 (ja) 2014-03-30 2019-09-11 セフィエド 修飾チミンポリヌクレオチドオリゴマーおよび方法
AU2015274660B2 (en) 2014-06-10 2020-07-16 Dxterity Diagnostics Incorporated Devices and methods for collecting and stabilizing biological samples
JP6820830B2 (ja) 2014-07-18 2021-01-27 ユニヴァーシティ オブ ワシントン がんワクチン組成物およびその使用方法
DK3174976T3 (da) 2014-08-01 2020-11-23 Gpb Scient Inc Fremgangsmåder og systemer til forarbejdning af partikler
US10913973B2 (en) 2014-09-17 2021-02-09 Board Of Regents, The University Texas System Methods and devices related to toehold-based strand displacement with loop-mediated isothermal amplification
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
JP2018502309A (ja) 2014-11-11 2018-01-25 ジェンマーク ダイアグノスティクス， インコーポレイテッド 閉止サンプル調製・反応システムにおいて、アッセイを実行するための装置及びカートリッジ
EP3226889A4 (de) 2014-11-19 2018-11-21 The Trustees of Columbia University in the City of New York Osteocalcin zur behandlung von gebrechlichkeit im zusammenhang mit alterung
US9909169B2 (en) 2014-12-17 2018-03-06 Roche Molecular Systems, Inc. Allele-specific amplification of nucleic acids using blocking oligonucleotides for wild type suppression
AU2015372584A1 (en) 2014-12-30 2017-06-29 Telomere Diagnostics, Inc. Multiplex quantitative PCR
SG11201706504RA (en) 2015-02-10 2017-09-28 Illumina Inc Methods and compositions for analyzing cellular components
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
WO2016160544A1 (en) 2015-03-27 2016-10-06 The Scripps Research Institute Lipid probes and uses thereof
US11318305B2 (en) 2015-03-31 2022-05-03 Oncosec Medical Incorporated Systems and methods for improved tissue-sensing based electroporation
CN104845967B (zh) 2015-04-15 2020-12-11 苏州新海生物科技股份有限公司 寡聚核苷酸片段及使用其的选择性扩增目标核酸序列变异体的方法及应用
WO2016176617A2 (en) 2015-04-29 2016-11-03 New York University Method for treating high-grade gliomas
WO2016197106A1 (en) 2015-06-05 2016-12-08 Miroculus Inc. Evaporation management in digital microfluidic devices
WO2016197103A1 (en) 2015-06-05 2016-12-08 Miroculus Inc. Air-matrix digital microfluidics apparatuses and methods for limiting evaporation and surface fouling
WO2016201111A1 (en) 2015-06-09 2016-12-15 Centrillion Technology Holdings Corporation Methods for sequencing nucleic acids
US11174313B2 (en) 2015-06-12 2021-11-16 Alector Llc Anti-CD33 antibodies and methods of use thereof
US11136390B2 (en) 2015-06-12 2021-10-05 Alector Llc Anti-CD33 antibodies and methods of use thereof
US10584378B2 (en) 2015-08-13 2020-03-10 Centrillion Technology Holdings Corporation Methods for synchronizing nucleic acid molecules
KR20180054639A (ko) 2015-08-28 2018-05-24 알렉터 엘엘씨 항-siglec-7 항체 및 이의 사용 방법
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
EP3859333A1 (de) 2015-09-10 2021-08-04 InSilixa, Inc. Systeme für quantitative multiplex-nukleinsäureamplifikation
ES2941968T3 (es) 2015-10-01 2023-05-29 The Whitehead Institute For Biomedical Res Marcaje de anticuerpos
EP3368575A2 (de) 2015-10-29 2018-09-05 Alector LLC Anti-siglec-9-antikörper und verfahren zur verwendung davon
CA3006759A1 (en) 2015-11-30 2017-06-08 The Regents Of The University Of California Tumor-specific payload delivery and immune activation using a human antibody targeting a highly specific tumor cell surface antigen
AU2016385135B2 (en) 2016-01-06 2022-02-17 The University Of British Columbia Bifurcating mixers and methods of their use and manufacture
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
WO2017181163A2 (en) 2016-04-16 2017-10-19 Oncocyte Corporation Methods and compositions for detection and diagnosis of breast cancer
WO2017192743A1 (en) 2016-05-04 2017-11-09 Abilita Bio, Inc. Methods and platform for preparing multispanning membrane proteins
WO2017201315A1 (en) 2016-05-18 2017-11-23 Roche Sequencing Solutions, Inc. Quantitative real time pcr amplification using an electrowetting-based device
CN109477133B (zh) 2016-06-09 2023-04-11 加利福尼亚大学董事会 用于纸基免疫测定的生物标志物浓缩和信号放大以及用于提取、浓缩和扩增dna的单一平台
EP3500660A4 (de) 2016-08-22 2020-03-04 Miroculus Inc. Rückkopplungssystem für parallele tröpfchensteuerung in einer digitalen mikrofluidischen vorrichtung
US11300578B2 (en) 2016-09-19 2022-04-12 Roche Molecular Systems, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
EP3538551A4 (de) 2016-11-10 2020-11-11 Fortis Therapeutics, Inc. Cd46-specifische effektorzellen und verwendungen davon
EP3538153B1 (de) 2016-11-11 2024-10-09 The Regents of the University of California Anti-cd46-antikörper und verfahren zur verwendung
US11147249B2 (en) 2016-12-08 2021-10-19 Alector Llc Siglec transgenic mice and methods of use thereof
WO2018126082A1 (en) 2016-12-28 2018-07-05 Miroculis Inc. Digital microfluidic devices and methods
CA3050260A1 (en) 2017-01-18 2018-07-26 The Scripps Research Institute Photoreactive ligands and uses thereof
EP3574109B1 (de) 2017-01-24 2023-07-26 Vastogen, Inc. Verfahren zur konstruktion von kopien von nukleinsäuremolekülen
CN110545850A (zh) 2017-03-10 2019-12-06 奎亚培格制药公司 可释放的缀合物
US11623219B2 (en) 2017-04-04 2023-04-11 Miroculus Inc. Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets
US11299776B2 (en) 2017-05-10 2022-04-12 Board Of Regents, The University Of Texas System Methods and devices related to amplifying nucleic acid at a variety of temperatures
US11359014B2 (en) 2017-05-16 2022-06-14 Alector Llc Anti-siglec-5 antibodies and methods of use thereof
MX2019014415A (es) 2017-06-16 2020-02-05 Eisai R&D Man Co Ltd Compuesto monomerico de acido nucleico modificado y analogo de acido oligonucleico.
CN110892258A (zh) 2017-07-24 2020-03-17 米罗库鲁斯公司 具有集成的血浆收集设备的数字微流控系统和方法
CN117700548A (zh) 2017-08-03 2024-03-15 艾利妥 抗cd33抗体及其使用方法
WO2019046860A1 (en) 2017-09-01 2019-03-07 Miroculus Inc. DIGITAL MICROFLUIDIC DEVICES AND METHODS OF USE
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
WO2019092269A1 (en) 2017-11-13 2019-05-16 F. Hoffmann-La Roche Ag Devices for sample analysis using epitachophoresis
US11728007B2 (en) 2017-11-30 2023-08-15 Grail, Llc Methods and systems for analyzing nucleic acid sequences using mappability analysis and de novo sequence assembly
US11470827B2 (en) 2017-12-12 2022-10-18 Alector Llc Transgenic mice expressing human TREM proteins and methods of use thereof
US20210189460A1 (en) 2018-04-25 2021-06-24 Qiagen Sciences Llc Sequential paired-end sequencing
CA3096855A1 (en) 2018-05-23 2019-11-28 Miroculus Inc. Control of evaporation in digital microfluidics
BR112021001451A2 (pt) 2018-07-27 2021-04-27 Alector Llc anticorpos monoclonais anti-siglec-5 isolados, ácido nucleico, vetor, célula hospedeira, métodos de produção de um anticorpo e de prevenção, composição farmacêutica e métodos para induzir ou promover a sobrevida, para diminuir a atividade, para diminuir os níveis celulares, para induzir a produção de espécies reativas, para induzir a formação de neutrophil extracellular trap (net), para induzir a ativação de neutrófilos, para atenuar um ou mais neutrófilos imunossuprimidos e para aumentar a atividade de fagocitose
WO2020053815A1 (en) 2018-09-12 2020-03-19 Quiapeg Pharmaceuticals Ab Releasable glp-1 conjugates
JP2022501374A (ja) 2018-09-21 2022-01-06 プレジデント アンド フェローズ オブ ハーバード カレッジ 糖尿病を治療するための方法及び組成物、ならびに分泌タンパク質をコードするｍＲＮＡを濃縮する方法
WO2020074742A1 (en) 2018-10-12 2020-04-16 F. Hoffmann-La Roche Ag Detection methods for epitachophoresis workflow automation
NL2022043B1 (en) 2018-11-21 2020-06-03 Akershus Univ Hf Tagmentation-Associated Multiplex PCR Enrichment Sequencing
CN112639126A (zh) 2018-12-14 2021-04-09 伊卢米纳剑桥有限公司 降低测序期间用未标记的核苷酸的定相
CA3103750A1 (en) 2018-12-17 2020-06-25 Illumina Cambridge Limited Primer oligonucleotide for sequencing
AU2019411266A1 (en) 2018-12-17 2021-01-07 Illumina Cambridge Limited Compositions for use in polyunucleotide sequencing
CN113924041A (zh) 2019-03-14 2022-01-11 因斯利克萨公司 基于时间门控的荧光检测的方法和系统
CA3133124A1 (en) 2019-04-08 2020-10-15 Miroculus Inc. Multi-cartridge digital microfluidics apparatuses and methods of use
WO2020229437A1 (en) 2019-05-14 2020-11-19 F. Hoffmann-La Roche Ag Devices and methods for sample analysis
US11377655B2 (en) 2019-07-16 2022-07-05 Pacific Biosciences Of California, Inc. Synthetic nucleic acids having non-natural structures
US11524298B2 (en) 2019-07-25 2022-12-13 Miroculus Inc. Digital microfluidics devices and methods of use thereof
CN114728996B (zh) 2019-09-10 2022-11-29 加利福尼亚太平洋生物科学股份有限公司 核苷酸的可逆修饰
US12059674B2 (en) 2020-02-03 2024-08-13 Tecan Genomics, Inc. Reagent storage system
US20210381039A1 (en) 2020-05-29 2021-12-09 Front Range Biosciences, Inc. Methods and compositions for pathogen detection in plants
CA3188481A1 (en) 2020-06-29 2022-01-06 Front Range Biosciences, Inc. Characterization of cannabis cultivars based on terpene synthase gene profiles
BR112023002346A2 (pt) 2020-08-07 2023-05-02 Fortis Therapeutics Inc Imunoconjugados direcionados a cd46 e métodos de uso dos mesmos
US20230096386A1 (en) 2021-09-30 2023-03-30 Illumina Cambridge Limited Polynucleotide sequencing
AU2022424380A1 (en) 2021-12-29 2024-01-18 Illumina, Inc. Methods of nucleic acid sequencing using surface-bound primers
US11772093B2 (en) 2022-01-12 2023-10-03 Miroculus Inc. Methods of mechanical microfluidic manipulation

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687808A (en) * 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
US4547569A (en) * 1982-11-24 1985-10-15 The United States Of America As Represented By The Department Of Health And Human Services Intercalating agents specifying nucleotides
US4959463A (en) * 1985-10-15 1990-09-25 Genentech, Inc. Intermediates
US5218103A (en) * 1988-05-26 1993-06-08 University Patents, Inc. Nucleoside thiophosphoramidites
US4958013A (en) * 1989-06-06 1990-09-18 Northwestern University Cholesteryl modified oligonucleotides
US5578718A (en) * 1990-01-11 1996-11-26 Isis Pharmaceuticals, Inc. Thiol-derivatized nucleosides
IE66205B1 (en) * 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
WO1993004204A1 (en) * 1991-08-23 1993-03-04 Isis Pharmaceuticals, Inc. Synthetic unrandomization of oligomer fragments
AU2916292A (en) * 1991-10-24 1993-05-21 Isis Pharmaceuticals, Inc. Derivatized oligonucleotides having improved uptake and other properties
US5272250A (en) * 1992-07-10 1993-12-21 Spielvogel Bernard F Boronated phosphoramidate compounds
WO1994004550A1 (en) * 1992-08-21 1994-03-03 Triplex Pharmaceutical Corporation Cholesteryl-modified triple-helix forming oligonucleotides and uses thereof
US5362899A (en) * 1993-09-09 1994-11-08 Affymax Technologies, N.V. Chiral synthesis of alpha-aminophosponic acids
US5519134A (en) * 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5587471A (en) * 1994-01-11 1996-12-24 Isis Pharmaceuticals, Inc. Method of making oligonucleotide libraries

Also Published As

Publication number Publication date
WO1995023160A1 (en) 1995-08-31
EP0751948A1 (de) 1997-01-08
US5637684A (en) 1997-06-10
ATE224908T1 (de) 2002-10-15
JPH09509663A (ja) 1997-09-30
AU1969195A (en) 1995-09-11
US5717083A (en) 1998-02-10
CA2184005C (en) 2000-01-25
CA2184005A1 (en) 1995-08-31
EP0751948B1 (de) 2002-09-25
EP0751948A4 (de) 1997-03-19
AU677150B2 (en) 1997-04-10
JP2972344B2 (ja) 1999-11-08

Similar Documents

Publication Publication Date Title
DE69528362D1 (de) Oligomere phosphoramidat- und phosphorthioamidatverbindungen
BR9705447A (pt) Microcápsulas usando poliisocianatos de iminooxadiazinadiona
BR9915651A (pt) Processo para a preparação de ácidos alcanossulfÈnicos.
TR199901734T2 (xx) N�rotrofinlerin ar�t�lmas�.
WO2000040525A3 (en) Polymer arrays and methods of making and using same
ES2163638T3 (es) Nuevas n-(1-alquil-5-fenil-2,3,4,5-tetrahidro-1h-benzo(b)(1,5)diacepin-3-il)acetamidas.
DE69534300D1 (de) Neues multimerisierendes reagenz
ATE288900T1 (de) Substituierte benzoylcyclohexandione
ES2193241T3 (es) Nuevas n-2-oxo2.3.4.5-tetrajodrp-1h-1,5-benzodiazepin-3-il)-3-amidas.
BR9610645A (pt) Milho apomìtico
AU3143897A (en) Oligonucleotides which specifically bind retroviral nucleocapsid proteins
TR199801039T2 (xx) Yeni fenilamidin t�revlerinin elde edilmesine y�nelik usul.
DE59509910D1 (de) Verfahren zur Herstellung von Alkylhydrogenchlorsilanen
ES2194102T3 (es) Nuevas n-(2,4-dioxo-2,3,4,5-tetrahidro-1h-1,5-benzodiazepin-3-il)-3-amidas.
ATE427959T1 (de) Gereinigtes sr-p70 protein
AU1343388A (en) Iodinated polymers
CA2192786A1 (en) Cyclopeptolide inhibitors of adhesion molecules
TR199701202T1 (xx) Yeni hidroksimik asit t�revleri.
DE69729959D1 (de) Hybride zusammensetzungen für intrazellulaire verabreichung
FI953363A0 (fi) Dimeeriblokkien synteesi ja niiden käyttö oligonukleotidien kokoamisessa
BR9713176A (pt) Benzotiofenos amorfos,métodos de preparação e métodos de uso
SE9604582D0 (sv) Novel compounds
BR9712773A (pt) Processo para a sìntese de benzotiofenos
WO1998054344A3 (en) Modulators of morphogen expression and methods of identifying the same
FR2718448B3 (fr) Dérivés d'acides aminoboroniques, leur préparation et leur utilisation comme intermédiaires de synthèse.

Legal Events

Date Code Title Description
8332 No legal effect for de