ATE224908T1 - Oligomere phosphoramidat- und phosphorthioamidatverbindungen - Google Patents

Oligomere phosphoramidat- und phosphorthioamidatverbindungen

Info

Publication number
ATE224908T1
ATE224908T1 AT95912595T AT95912595T ATE224908T1 AT E224908 T1 ATE224908 T1 AT E224908T1 AT 95912595 T AT95912595 T AT 95912595T AT 95912595 T AT95912595 T AT 95912595T AT E224908 T1 ATE224908 T1 AT E224908T1
Authority
AT
Austria
Prior art keywords
groups
compounds
phosphorthioamidate
phosphoramidate
oligomeric
Prior art date
Application number
AT95912595T
Other languages
English (en)
Inventor
Phillip Dan Cook
Oscar Acevedo
Normand Hebert
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE224908T1 publication Critical patent/ATE224908T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Luminescent Compositions (AREA)
AT95912595T 1994-02-23 1995-02-23 Oligomere phosphoramidat- und phosphorthioamidatverbindungen ATE224908T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/200,638 US5637684A (en) 1994-02-23 1994-02-23 Phosphoramidate and phosphorothioamidate oligomeric compounds
PCT/US1995/002267 WO1995023160A1 (en) 1994-02-23 1995-02-23 Novel phosphoramidate and phophorothioamidate oligomeric compounds

Publications (1)

Publication Number Publication Date
ATE224908T1 true ATE224908T1 (de) 2002-10-15

Family

ID=22742548

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95912595T ATE224908T1 (de) 1994-02-23 1995-02-23 Oligomere phosphoramidat- und phosphorthioamidatverbindungen

Country Status (8)

Country Link
US (2) US5637684A (de)
EP (1) EP0751948B1 (de)
JP (1) JP2972344B2 (de)
AT (1) ATE224908T1 (de)
AU (1) AU677150B2 (de)
CA (1) CA2184005C (de)
DE (1) DE69528362D1 (de)
WO (1) WO1995023160A1 (de)

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EP0751948A4 (de) 1997-03-19
JPH09509663A (ja) 1997-09-30
JP2972344B2 (ja) 1999-11-08
US5637684A (en) 1997-06-10
AU677150B2 (en) 1997-04-10
CA2184005A1 (en) 1995-08-31
EP0751948B1 (de) 2002-09-25
WO1995023160A1 (en) 1995-08-31
AU1969195A (en) 1995-09-11
CA2184005C (en) 2000-01-25
EP0751948A1 (de) 1997-01-08
US5717083A (en) 1998-02-10

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