ATE196899T1 - N-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5- benzodiazepin-3-yl)-3-amide - Google Patents

N-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5- benzodiazepin-3-yl)-3-amide

Info

Publication number
ATE196899T1
ATE196899T1 AT96916983T AT96916983T ATE196899T1 AT E196899 T1 ATE196899 T1 AT E196899T1 AT 96916983 T AT96916983 T AT 96916983T AT 96916983 T AT96916983 T AT 96916983T AT E196899 T1 ATE196899 T1 AT E196899T1
Authority
AT
Austria
Prior art keywords
benzodiazepine
dioxo
tetrahydro
amide
formula
Prior art date
Application number
AT96916983T
Other languages
English (en)
Inventor
David A Claremon
Roger M Freidinger
Nigel Liverton
Harold G Selnick
Garry R Smith
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE196899T1 publication Critical patent/ATE196899T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT96916983T 1995-06-07 1996-06-03 N-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5- benzodiazepin-3-yl)-3-amide ATE196899T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/474,801 US5691331A (en) 1995-06-07 1995-06-07 N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides
PCT/US1996/008400 WO1996040655A1 (en) 1995-06-07 1996-06-03 Novel n-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3y l)-3-amides

Publications (1)

Publication Number Publication Date
ATE196899T1 true ATE196899T1 (de) 2000-10-15

Family

ID=23884989

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96916983T ATE196899T1 (de) 1995-06-07 1996-06-03 N-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5- benzodiazepin-3-yl)-3-amide

Country Status (12)

Country Link
US (1) US5691331A (de)
EP (1) EP0832075B1 (de)
JP (1) JPH11506758A (de)
AT (1) ATE196899T1 (de)
AU (1) AU704015B2 (de)
CA (1) CA2222492A1 (de)
DE (1) DE69610628T2 (de)
DK (1) DK0832075T3 (de)
ES (1) ES2151168T3 (de)
GR (1) GR3034602T3 (de)
PT (1) PT832075E (de)
WO (1) WO1996040655A1 (de)

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US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
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US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
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US20100009966A1 (en) * 2001-04-11 2010-01-14 Bristol-Myers Squibb Pharma Company Substituted lactams as inhibitors of abeta protein production
CA2404273A1 (en) * 2000-04-11 2001-10-18 Bristol-Myers Squibb Pharma Company Substituted lactams as inhibitors of a.beta. protein production
EP2254873B1 (de) * 2008-02-22 2014-06-04 Otsuka Pharmaceutical Co., Ltd. Benzodiazepinverbindung und pharmazeutische zusammensetzung
TWI481601B (zh) * 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
KR20120065360A (ko) 2009-08-21 2012-06-20 오츠카 세이야쿠 가부시키가이샤 벤조［ｂ］［1,4］디아제핀-2,4-디온 화합물의 제조 방법
JP2012184225A (ja) * 2011-02-18 2012-09-27 Otsuka Pharmaceut Co Ltd 医薬組成物
CN118994191A (zh) 2016-02-05 2024-11-22 戴纳立制药公司 受体相互作用蛋白激酶1的抑制剂
HRP20220636T1 (hr) 2016-12-09 2022-07-22 Denali Therapeutics Inc. Spojevi korisni kao inhibitori ripk1
AU2023206890A1 (en) 2022-01-12 2024-08-22 Denali Therapeutics Inc. Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide

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Also Published As

Publication number Publication date
DK0832075T3 (da) 2000-11-20
US5691331A (en) 1997-11-25
DE69610628T2 (de) 2001-05-23
EP0832075A4 (de) 1998-10-07
GR3034602T3 (en) 2001-01-31
PT832075E (pt) 2001-03-30
AU704015B2 (en) 1999-04-01
JPH11506758A (ja) 1999-06-15
AU5968896A (en) 1996-12-30
EP0832075A1 (de) 1998-04-01
ES2151168T3 (es) 2000-12-16
DE69610628D1 (de) 2000-11-16
CA2222492A1 (en) 1996-12-19
WO1996040655A1 (en) 1996-12-19
EP0832075B1 (de) 2000-10-11

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee