HUS2100048I1 - Adenin-származék mint PI3K inhibitor - Google Patents

Adenin-származék mint PI3K inhibitor

Info

Publication number
HUS2100048I1
HUS2100048I1 HUS2100048C HUS2100048C HUS2100048I1 HU S2100048 I1 HUS2100048 I1 HU S2100048I1 HU S2100048 C HUS2100048 C HU S2100048C HU S2100048 C HUS2100048 C HU S2100048C HU S2100048 I1 HUS2100048 I1 HU S2100048I1
Authority
HU
Hungary
Prior art keywords
pi3k inhibitor
adenine derivative
adenine
derivative
pi3k
Prior art date
Application number
HUS2100048C
Other languages
English (en)
Hungarian (hu)
Original Assignee
Intellikine Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intellikine Llc filed Critical Intellikine Llc
Publication of HUS2100048I1 publication Critical patent/HUS2100048I1/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
HUS2100048C 2009-07-15 2021-11-11 Adenin-származék mint PI3K inhibitor HUS2100048I1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/503,776 US8193182B2 (en) 2008-01-04 2009-07-15 Substituted isoquinolin-1(2H)-ones, and methods of use thereof
EP10800175.1A EP2456444B1 (en) 2009-07-15 2010-07-15 Adenine derivative as pi3k inhibitor
PCT/US2010/002020 WO2011008302A1 (en) 2009-07-15 2010-07-15 Certain chemical entities, compositions and methods

Publications (1)

Publication Number Publication Date
HUS2100048I1 true HUS2100048I1 (hu) 2021-12-28

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Family Applications (1)

Application Number Title Priority Date Filing Date
HUS2100048C HUS2100048I1 (hu) 2009-07-15 2021-11-11 Adenin-származék mint PI3K inhibitor

Country Status (33)

Country Link
US (13) US8193182B2 (h)
EP (4) EP2456444B1 (h)
JP (2) JP5944313B2 (h)
KR (1) KR101680406B1 (h)
CN (3) CN102711767B (h)
AU (1) AU2010274075B2 (h)
BR (1) BR112012000968B8 (h)
CA (1) CA2768307C (h)
CY (2) CY1116424T1 (h)
DK (1) DK2456444T3 (h)
ES (1) ES2538853T3 (h)
FI (1) FIC20210039I1 (h)
HR (1) HRP20150586T1 (h)
HU (1) HUS2100048I1 (h)
IL (2) IL217181A (h)
IN (1) IN2012DN00943A (h)
LT (1) LTPA2021526I1 (h)
LU (1) LUC00237I2 (h)
MX (3) MX2012000626A (h)
MY (2) MY175979A (h)
NL (1) NL301140I2 (h)
NO (1) NO2021047I1 (h)
NZ (3) NZ597595A (h)
PH (2) PH12015502432A1 (h)
PL (1) PL2456444T3 (h)
PT (1) PT2456444E (h)
RU (2) RU2746319C2 (h)
SG (2) SG10201503886WA (h)
SI (1) SI2456444T1 (h)
SM (1) SMT201500141B (h)
UA (2) UA121192C2 (h)
WO (1) WO2011008302A1 (h)
ZA (1) ZA201200254B (h)

Families Citing this family (176)

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Publication number Priority date Publication date Assignee Title
BRPI0406647A (pt) * 2003-01-06 2005-12-06 Angiochem Inc Método para transportar um composto através da barreira sanguìnea do cérebro
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