BRPI0808444A2 - análogos de ciclopamina lactam e métodos de uso dos mesmos - Google Patents

análogos de ciclopamina lactam e métodos de uso dos mesmos

Info

Publication number
BRPI0808444A2
BRPI0808444A2 BRPI0808444A BRPI0808444A BRPI0808444A2 BR PI0808444 A2 BRPI0808444 A2 BR PI0808444A2 BR PI0808444 A BRPI0808444 A BR PI0808444A BR PI0808444 A BRPI0808444 A BR PI0808444A BR PI0808444 A2 BRPI0808444 A2 BR PI0808444A2
Authority
BR
Brazil
Prior art keywords
lactate
methods
cyclopamine analogues
cyclopamine
analogues
Prior art date
Application number
BRPI0808444A
Other languages
English (en)
Inventor
C Castro Alfredo
Lescarbeau Andre
r tremblay Martin
J Grogan Michael
Original Assignee
Infinity Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infinity Discovery Inc filed Critical Infinity Discovery Inc
Publication of BRPI0808444A2 publication Critical patent/BRPI0808444A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
BRPI0808444A 2007-03-07 2008-03-07 análogos de ciclopamina lactam e métodos de uso dos mesmos BRPI0808444A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89359107P 2007-03-07 2007-03-07
PCT/US2008/056229 WO2008109829A1 (en) 2007-03-07 2008-03-07 Cyclopamine lactam analogs and methods of use thereof

Publications (1)

Publication Number Publication Date
BRPI0808444A2 true BRPI0808444A2 (pt) 2017-06-06

Family

ID=39738826

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0808444A BRPI0808444A2 (pt) 2007-03-07 2008-03-07 análogos de ciclopamina lactam e métodos de uso dos mesmos

Country Status (15)

Country Link
US (3) US7964590B2 (pt)
EP (1) EP2134719B1 (pt)
JP (1) JP2010520310A (pt)
KR (1) KR20090117956A (pt)
CN (2) CN104193797A (pt)
AU (1) AU2008222655B2 (pt)
BR (1) BRPI0808444A2 (pt)
CA (1) CA2679845A1 (pt)
HK (1) HK1139930A1 (pt)
IL (1) IL200746A0 (pt)
MX (1) MX2009009429A (pt)
NZ (1) NZ579356A (pt)
RU (1) RU2009137012A (pt)
WO (1) WO2008109829A1 (pt)
ZA (1) ZA200906083B (pt)

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CA2769795C (en) 2009-08-05 2020-01-07 Infinity Pharmaceuticals, Inc. Enzymatic transamination of cyclopamine analogs
US20110065645A1 (en) * 2009-09-10 2011-03-17 The Regents Of The University Of California Compositions and Methods for Modulating Neuron Degeneration and Neuron Guidance
WO2011088404A1 (en) * 2010-01-15 2011-07-21 Infinity Pharmaceuticals , Inc Treatment of fibrotic conditions using hedgehog inhibitors
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CA2842190A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
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ES2709480T3 (es) 2013-12-24 2019-04-16 Harvard College Análogos de cortistatina y síntesis y usos de los mismos
JP6701088B2 (ja) 2014-03-19 2020-05-27 インフィニティー ファーマシューティカルズ， インコーポレイテッド Ｐｉ３ｋ−ガンマ媒介障害の治療で使用するための複素環式化合物
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Also Published As

Publication number Publication date
CN104193797A (zh) 2014-12-10
ZA200906083B (en) 2011-03-30
HK1139930A1 (en) 2010-09-30
WO2008109829A1 (en) 2008-09-12
US8293760B2 (en) 2012-10-23
EP2134719B1 (en) 2013-07-17
RU2009137012A (ru) 2011-04-20
CN101675054A (zh) 2010-03-17
US7964590B2 (en) 2011-06-21
NZ579356A (en) 2012-04-27
KR20090117956A (ko) 2009-11-16
US20080287420A1 (en) 2008-11-20
EP2134719A1 (en) 2009-12-23
AU2008222655B2 (en) 2014-03-27
US8431566B2 (en) 2013-04-30
AU2008222655A1 (en) 2008-09-12
US20120083484A1 (en) 2012-04-05
CN101675054B (zh) 2014-05-14
JP2010520310A (ja) 2010-06-10
CA2679845A1 (en) 2008-09-12
US20120015934A1 (en) 2012-01-19
MX2009009429A (es) 2010-07-05
IL200746A0 (en) 2010-05-17
EP2134719A4 (en) 2011-08-17

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]