MX2009009429A - Analogos de ciclopamina lactama y metodos de uso de los mismos. - Google Patents

Analogos de ciclopamina lactama y metodos de uso de los mismos.

Info

Publication number
MX2009009429A
MX2009009429A MX2009009429A MX2009009429A MX2009009429A MX 2009009429 A MX2009009429 A MX 2009009429A MX 2009009429 A MX2009009429 A MX 2009009429A MX 2009009429 A MX2009009429 A MX 2009009429A MX 2009009429 A MX2009009429 A MX 2009009429A
Authority
MX
Mexico
Prior art keywords
methods
lactam analogs
cyclopamine
cyclopamine lactam
analogs
Prior art date
Application number
MX2009009429A
Other languages
English (en)
Inventor
Alfredo C Castro
Michael J Grogan
Andre Lescarbeau
Martin R Tremblay
Original Assignee
Infinity Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infinity Discovery Inc filed Critical Infinity Discovery Inc
Publication of MX2009009429A publication Critical patent/MX2009009429A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se relaciona a alcaloides esteroidales útiles en el tratamiento de desórdenes relacionados con la ruta hedgehog, particularmente cánceres.
MX2009009429A 2007-03-07 2008-03-07 Analogos de ciclopamina lactama y metodos de uso de los mismos. MX2009009429A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89359107P 2007-03-07 2007-03-07
PCT/US2008/056229 WO2008109829A1 (en) 2007-03-07 2008-03-07 Cyclopamine lactam analogs and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2009009429A true MX2009009429A (es) 2010-07-05

Family

ID=39738826

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009009429A MX2009009429A (es) 2007-03-07 2008-03-07 Analogos de ciclopamina lactama y metodos de uso de los mismos.

Country Status (15)

Country Link
US (3) US7964590B2 (es)
EP (1) EP2134719B1 (es)
JP (1) JP2010520310A (es)
KR (1) KR20090117956A (es)
CN (2) CN101675054B (es)
AU (1) AU2008222655B2 (es)
BR (1) BRPI0808444A2 (es)
CA (1) CA2679845A1 (es)
HK (1) HK1139930A1 (es)
IL (1) IL200746A0 (es)
MX (1) MX2009009429A (es)
NZ (1) NZ579356A (es)
RU (1) RU2009137012A (es)
WO (1) WO2008109829A1 (es)
ZA (1) ZA200906083B (es)

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BRPI0808663A2 (pt) * 2007-03-07 2014-08-26 Infinity Discovery Inc Análogos de cicloamina heterocíclicos e métodos de uso dos mesmos
MX2009009429A (es) 2007-03-07 2010-07-05 Infinity Discovery Inc Analogos de ciclopamina lactama y metodos de uso de los mismos.
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ES2567134T3 (es) 2009-08-05 2016-04-20 Infinity Pharmaceuticals, Inc. Transaminación enzimática de análogos de ciclopamina
US20110065645A1 (en) * 2009-09-10 2011-03-17 The Regents Of The University Of California Compositions and Methods for Modulating Neuron Degeneration and Neuron Guidance
US20110183948A1 (en) * 2010-01-15 2011-07-28 Infinity Pharmaceuticals, Inc. Treatment of fibrotic conditions using hedgehog inhibitors
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US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
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Also Published As

Publication number Publication date
WO2008109829A1 (en) 2008-09-12
AU2008222655A1 (en) 2008-09-12
ZA200906083B (en) 2011-03-30
EP2134719B1 (en) 2013-07-17
EP2134719A1 (en) 2009-12-23
IL200746A0 (en) 2010-05-17
RU2009137012A (ru) 2011-04-20
US20080287420A1 (en) 2008-11-20
HK1139930A1 (en) 2010-09-30
US20120083484A1 (en) 2012-04-05
US8293760B2 (en) 2012-10-23
JP2010520310A (ja) 2010-06-10
CN104193797A (zh) 2014-12-10
AU2008222655B2 (en) 2014-03-27
NZ579356A (en) 2012-04-27
US20120015934A1 (en) 2012-01-19
KR20090117956A (ko) 2009-11-16
CN101675054B (zh) 2014-05-14
US7964590B2 (en) 2011-06-21
CA2679845A1 (en) 2008-09-12
EP2134719A4 (en) 2011-08-17
US8431566B2 (en) 2013-04-30
BRPI0808444A2 (pt) 2017-06-06
CN101675054A (zh) 2010-03-17

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