ES2033626T1 - Formulacion adyuvante que comprende una emulsion de gotitas de aceite submicroscopicas. - Google Patents

Formulacion adyuvante que comprende una emulsion de gotitas de aceite submicroscopicas.

Info

Publication number
ES2033626T1
ES2033626T1 ES199090305744T ES90305744T ES2033626T1 ES 2033626 T1 ES2033626 T1 ES 2033626T1 ES 199090305744 T ES199090305744 T ES 199090305744T ES 90305744 T ES90305744 T ES 90305744T ES 2033626 T1 ES2033626 T1 ES 2033626T1
Authority
ES
Spain
Prior art keywords
oil
emulsion
submicroscopic
oil drops
adjuvant formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES199090305744T
Other languages
English (en)
Other versions
ES2033626T3 (es
Inventor
Gary Van Nest
Gary Ott
Gail Barchfeld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23404033&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2033626(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of ES2033626T1 publication Critical patent/ES2033626T1/es
Application granted granted Critical
Publication of ES2033626T3 publication Critical patent/ES2033626T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/802—Virus-based particle
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/918—Immunological

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Colloid Chemistry (AREA)
  • Detergent Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE PRESENTA UN COMPUESTO ADJUTOR, QUE COMPRENDE UN ACEITE METABOLIZABLE Y UN AGENTE EMULSIONANTE, EN EL QUE EL ACEITE Y EL DETERGENTE ESTAN PRESENTES EN LA FORMULA DE UNA EMULSION EN ACEITE EN AGUA QUE TIENE GOTITAS DE ACEITE DE TAMAÑO DE DIAMETRO INFERIOR A UN MICRON. EN SU CONFORMACION MAS ADECUADA, EL AGENTE EMULSIONANTE ES TAMBIEN UN AGENTE INMUNOESTIMULANTE, TAL COMO UN PEPTIDO MURAMIL LIPOFILICO. ALTERNATIVAMENTE, PUEDE USARSE UN AGENTE INMUNOESTIMULADOR SEPARADO DEL AGENTE EMULSIONANTE.
ES90305744T 1989-05-25 1990-05-25 Formulacion de adyuvante que comprende una emulsion de gota de aceite submicronica. Expired - Lifetime ES2033626T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35703589A 1989-05-25 1989-05-25

Publications (2)

Publication Number Publication Date
ES2033626T1 true ES2033626T1 (es) 1993-04-01
ES2033626T3 ES2033626T3 (es) 1994-10-16

Family

ID=23404033

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90305744T Expired - Lifetime ES2033626T3 (es) 1989-05-25 1990-05-25 Formulacion de adyuvante que comprende una emulsion de gota de aceite submicronica.

Country Status (15)

Country Link
US (3) US6299884B1 (es)
EP (1) EP0399843B1 (es)
JP (1) JPH0832638B2 (es)
AT (1) ATE108327T1 (es)
CA (1) CA2017507C (es)
DD (1) DD294633A5 (es)
DE (2) DE399843T1 (es)
DK (1) DK0399843T5 (es)
ES (1) ES2033626T3 (es)
GR (1) GR910300063T1 (es)
HK (1) HK107695A (es)
HU (1) HU212924B (es)
IE (1) IE64766B1 (es)
PT (1) PT94168B (es)
WO (1) WO1990014837A1 (es)

Families Citing this family (648)

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DE69010574T2 (de) 1994-10-27
DK0399843T5 (da) 1994-09-19
IE64766B1 (en) 1995-09-06
US6299884B1 (en) 2001-10-09
JPH0832638B2 (ja) 1996-03-29
HU905459D0 (en) 1992-02-28
DE399843T1 (de) 1991-05-02
US6451325B1 (en) 2002-09-17
US20030147898A1 (en) 2003-08-07
HUT61203A (en) 1992-12-28
GR910300063T1 (en) 1991-11-15
US20090191226A2 (en) 2009-07-30
WO1990014837A1 (en) 1990-12-13
JPH05508385A (ja) 1993-11-25
ATE108327T1 (de) 1994-07-15
EP0399843A2 (en) 1990-11-28
EP0399843A3 (en) 1992-09-02
CA2017507C (en) 1996-11-12
DD294633A5 (de) 1991-10-10
CA2017507A1 (en) 1990-11-25
PT94168A (pt) 1991-01-08
PT94168B (pt) 2001-05-31
IE901903L (en) 1990-11-25
DE69010574D1 (de) 1994-08-18
HK107695A (en) 1995-07-14
HU212924B (en) 1996-12-30
EP0399843B1 (en) 1994-07-13
ES2033626T3 (es) 1994-10-16

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