GB201017519D0 - Vaccines - Google Patents

Vaccines

Info

Publication number
GB201017519D0
GB201017519D0 GBGB1017519.8A GB201017519A GB201017519D0 GB 201017519 D0 GB201017519 D0 GB 201017519D0 GB 201017519 A GB201017519 A GB 201017519A GB 201017519 D0 GB201017519 D0 GB 201017519D0
Authority
GB
United Kingdom
Prior art keywords
blebs
immunogens
strains
vaccines
hyperblebbing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1017519.8A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines Institute for Global Health SRL
Original Assignee
Novartis Vaccines Institute for Global Health SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines Institute for Global Health SRL filed Critical Novartis Vaccines Institute for Global Health SRL
Priority to GBGB1017519.8A priority Critical patent/GB201017519D0/en
Publication of GB201017519D0 publication Critical patent/GB201017519D0/en
Application status is Ceased legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/255Salmonella (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/025Enterobacteriales, e.g. Enterobacter
    • A61K39/0275Salmonella
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • A61K2039/543Mucosal route intranasal
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y02A50/46Medical treatment of waterborne diseases characterized by the agent
    • Y02A50/468The waterborne disease being caused by a bacteria
    • Y02A50/481The waterborne disease being caused by a bacteria of the genus Salmonella, i.e. Salmonellosis
    • Y02A50/482The waterborne disease being caused by a bacteria of the genus Salmonella, i.e. Salmonellosis the medicinal preparation containing antigens or antibodies, e.g. vaccines, antisera
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y02A50/46Medical treatment of waterborne diseases characterized by the agent
    • Y02A50/468The waterborne disease being caused by a bacteria
    • Y02A50/481The waterborne disease being caused by a bacteria of the genus Salmonella, i.e. Salmonellosis
    • Y02A50/483The waterborne disease being caused by a bacteria of the genus Salmonella, i.e. Salmonellosis the bacteria being Salmonella typhi, i.e. Typhoid fever
    • Y02A50/484The waterborne disease being caused by a bacteria of the genus Salmonella, i.e. Salmonellosis the bacteria being Salmonella typhi, i.e. Typhoid fever the medicinal preparation containing antigens or antibodies, e.g. vaccines, antisera

Abstract

Hyperblebbing Salmonella strains are generated by disrupting one or more components of the Tol-Pal system, such as TolR. The blebs from these strains are useful immunogens for vaccination. The individual proteins found in these blebs can also be used as immunogens.
GBGB1017519.8A 2010-10-15 2010-10-15 Vaccines Ceased GB201017519D0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GBGB1017519.8A GB201017519D0 (en) 2010-10-15 2010-10-15 Vaccines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1017519.8A GB201017519D0 (en) 2010-10-15 2010-10-15 Vaccines
PCT/IB2011/054569 WO2012049662A1 (en) 2010-10-15 2011-10-14 Hyperblebbing salmonella strains

Publications (1)

Publication Number Publication Date
GB201017519D0 true GB201017519D0 (en) 2010-12-01

Family

ID=43333951

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1017519.8A Ceased GB201017519D0 (en) 2010-10-15 2010-10-15 Vaccines

Country Status (2)

Country Link
GB (1) GB201017519D0 (en)
WO (1) WO2012049662A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2870974A1 (en) 2013-11-08 2015-05-13 Novartis AG Salmonella conjugate vaccines
WO2015142875A1 (en) * 2014-03-17 2015-09-24 The Trustees Of The University Of Pennsylvania Compositions and methods using modified salmonella
MX2017016401A (en) * 2015-06-16 2018-03-02 Glaxosmithkline Biologicals Sa Immunogenic compositions.

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8205892D0 (en) 1982-10-18 1982-10-18 Bror Morein Immunogenic membrane protein complex, seen for the front up and tell priority over derav as immune stimulant and as vaccine
US6090406A (en) 1984-04-12 2000-07-18 The Liposome Company, Inc. Potentiation of immune responses with liposomal adjuvants
US5916588A (en) 1984-04-12 1999-06-29 The Liposome Company, Inc. Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
AU631377B2 (en) 1988-08-25 1992-11-26 Liposome Company, Inc., The Affinity associated vaccine
CA2017507C (en) 1989-05-25 1996-11-12 Gary Van Nest Adjuvant formulation comprising a submicron oil droplet emulsion
CZ282235B6 (en) 1992-06-25 1997-06-11 Smithkline Beecham Biologicals (S.A.) Inoculation substance, process of its preparation and use
DE69428136D1 (en) 1993-03-23 2001-10-04 Smithkline Beecham Biolog 3-0 Deazylierte monophosphoryl lipid A containing vaccine compositions
AU5543294A (en) 1993-10-29 1995-05-22 Pharmos Corp. Submicron emulsions as vaccine adjuvants
GB9326174D0 (en) 1993-12-22 1994-02-23 Biocine Sclavo Mucosal adjuvant
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
US6429199B1 (en) 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
AUPM873294A0 (en) 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
ES2140076T5 (en) 1995-04-25 2007-04-16 Smithkline Beecham Biologicals S.A. Vaccines containing a saponin and a sterol.
GB9513261D0 (en) 1995-06-29 1995-09-06 Smithkline Beecham Biolog Vaccines
EP1005368B1 (en) 1997-03-10 2009-09-02 Ottawa Hospital Research Institute Use of nucleic acids containing unmethylated CpG dinucleotide in combination with alum as adjuvants
US6818222B1 (en) 1997-03-21 2004-11-16 Chiron Corporation Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
US6080725A (en) 1997-05-20 2000-06-27 Galenica Pharmaceuticals, Inc. Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof
GB9712347D0 (en) 1997-06-14 1997-08-13 Smithkline Beecham Biolog Vaccine
CA2302554C (en) 1997-09-05 2007-04-10 Smithkline Beecham Biologicals S.A. Oil in water emulsions containing saponins
GB9725084D0 (en) 1997-11-28 1998-01-28 Medeva Europ Ltd Vaccine compositions
WO1999040936A2 (en) 1998-02-12 1999-08-19 American Cyanamid Company Pneumococcal and meningococcal vaccines formulated with interleukin-12
US6303114B1 (en) 1998-03-05 2001-10-16 The Medical College Of Ohio IL-12 enhancement of immune responses to T-independent antigens
US6562798B1 (en) 1998-06-05 2003-05-13 Dynavax Technologies Corp. Immunostimulatory oligonucleotides with modified bases and methods of use thereof
GB9817052D0 (en) 1998-08-05 1998-09-30 Smithkline Beecham Biolog Vaccine
AU3108001A (en) 2000-01-20 2001-12-24 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for inducing a th2 immune response
US7125718B2 (en) 2000-05-24 2006-10-24 University Of Maryland Biotechnology Institute Method for introducing and expressing genes in animal cells, and bacterial blebs for use in same
ES2298269T3 (en) 2000-09-26 2008-05-16 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory activity of immunostimulatory oligonucleotide Analogs by Positional chemical changes.
GB0103171D0 (en) * 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
WO2003035836A2 (en) 2001-10-24 2003-05-01 Hybridon Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
WO2004084938A1 (en) 2003-03-24 2004-10-07 Intercell Ag Improved vaccines
DK1742659T3 (en) 2004-04-05 2013-06-03 Zoetis P Llc Microfluidized oil-in-water emulsions and vaccine compositions
US20060228369A1 (en) 2005-04-11 2006-10-12 Program For Appropriate Technology In Health Stabilization and preservation of temperature-sensitive vaccines
US7691368B2 (en) 2005-04-15 2010-04-06 Merial Limited Vaccine formulations
US8703095B2 (en) 2005-07-07 2014-04-22 Sanofi Pasteur S.A. Immuno-adjuvant emulsion
GB0917002D0 (en) 2009-09-28 2009-11-11 Novartis Vaccines Inst For Global Health Srl Improved shigella blebs
GB0917003D0 (en) 2009-09-28 2009-11-11 Novartis Vaccines Inst For Global Health Srl Purification of bacterial vesicles

Also Published As

Publication number Publication date
WO2012049662A1 (en) 2012-04-19

Similar Documents

Publication Publication Date Title
JO3300B1 (en) Compounds and compositions for modulating egfr activity
MX2012013713A (en) Nanocarrier compositions with uncoupled adjuvant.
MX357823B (en) Chimeric antigen receptors targeting b-cell maturation antigen.
UA115144C2 (en) Pesticidal compositions and processes related thereto
IL222878D0 (en) Indoles
NZ607996A (en) Substituted nucleotide analogs
MX336682B (en) Antibodies against human csf-1r and uses thereof.
MX2016005297A (en) Inhibitors of the fibroblast growth factor receptor.
MX356337B (en) Antibodies against human csf-1r and uses thereof.
MX2013001045A (en) Liver organoid, uses thereof and culture method for obtaining them.
MD20150091A2 (en) Anti-viral compounds
TW201138821A (en) Bispecific antibodies
MX2015005810A (en) Anti-notch3 antibodies and antibody-drug conjugates.
TW201333028A (en) Substituted nucleotide analogs
MX349630B (en) Alpha-amylases.
MX2013008850A (en) Compositions and methods for treating cardiovascular diseases.
MX352662B (en) Glyphosate resistant plants and associated methods.
MX2013007923A (en) High value document authentication system & method.
WO2014158811A8 (en) Newcastle disease viruses and uses thereof
TW201609813A (en) Anti-TIGIT antibodies
TW201335345A (en) Flame retardant mixtures comprising flame retardant and aluminum phosphites, process for preparation thereof and use thereof
WO2015085318A3 (en) Targeted adaptive vaccines
WO2014116846A3 (en) Methods and compositions for modulating an immune response
WO2014143184A8 (en) Modulated lysine variant species compositions and methods for producing and using the same
MX2013002264A (en) Pesticidal compositions.

Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)