MX343410B - Emulsiones cationicas de agua en aceite. - Google Patents

Emulsiones cationicas de agua en aceite.

Info

Publication number
MX343410B
MX343410B MX2013000171A MX2013000171A MX343410B MX 343410 B MX343410 B MX 343410B MX 2013000171 A MX2013000171 A MX 2013000171A MX 2013000171 A MX2013000171 A MX 2013000171A MX 343410 B MX343410 B MX 343410B
Authority
MX
Mexico
Prior art keywords
cationic
water emulsions
molecule
nucleic acid
oil
Prior art date
Application number
MX2013000171A
Other languages
English (en)
Other versions
MX2013000171A (es
Inventor
O'hagan Derek
Singh Manmohan
Brito Luis
Geall Andrew
Original Assignee
Novartis Ag *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag * filed Critical Novartis Ag *
Publication of MX2013000171A publication Critical patent/MX2013000171A/es
Publication of MX343410B publication Critical patent/MX343410B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/275—Poxviridae, e.g. avipoxvirus
    • A61K39/285—Vaccinia virus or variola virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La presente invención se refiere a una composición que comprende una molécula de ARN acomplejada con una partícula de emulsión catiónica de aceite en agua, caracterizada porque la partícula comprende: (a) un núcleo de aceite que se encuentra en fase líquida a 25°C, y (b) un lípido catiónico, de manera que la carga neta total de la partícula de emulsión antes de la complejación de ARN es positiva, y en donde la molécula de ARN es un ARN autorreplicante que codifica par aun antígeno proteínico y el ARN se ancla a la superficie de la partícula por interacciones no covalentes; en donde, cuando se administra en una cantidad eficaz a un mamífero, la composición induce títulos de anticuerpo al antígeno iguales a o mayores que el ARN autorreplicante administrado al mamífero no acomplejado con la partícula. Esta invención se refiere generalmente a emulsiones catiónicas de aceite en agua que pueden ser usadas para suministrar moléculas cargadas negativamente, tales como una molécula de ARN. Las partículas de la emulsión comprenden un núcleo de aceite y un lípido catiónico. El lípido catiónico puede interactuar con la molécula cargada negativamente anclando de esta manera la molécula a las partículas de la emulsión. Las emulsiones catiónicas descritas en la presente son particularmente adecuadas para suministrar moléculas de ácido nucleico (tal como una molécula de ARN que codifica para un antígeno) a células, y para formular vacunas a base de ácido nucleico.
MX2013000171A 2010-07-06 2011-07-06 Emulsiones cationicas de agua en aceite. MX343410B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36189210P 2010-07-06 2010-07-06
PCT/US2011/043108 WO2012006380A2 (en) 2010-07-06 2011-07-06 Cationic oil-in-water emulsions

Publications (2)

Publication Number Publication Date
MX2013000171A MX2013000171A (es) 2013-03-05
MX343410B true MX343410B (es) 2016-11-04

Family

ID=44629230

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013000171A MX343410B (es) 2010-07-06 2011-07-06 Emulsiones cationicas de agua en aceite.

Country Status (12)

Country Link
US (3) US9295646B2 (es)
EP (2) EP2590625B1 (es)
JP (2) JP6025721B2 (es)
CN (2) CN103327963A (es)
AU (1) AU2011276236B2 (es)
BR (1) BR112013000391B8 (es)
CA (1) CA2804591C (es)
ES (1) ES2649896T3 (es)
MX (1) MX343410B (es)
NZ (1) NZ606591A (es)
RU (1) RU2625546C2 (es)
WO (1) WO2012006380A2 (es)

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