ATE350015T1 - Mikropartikelzusammensetzungen und verfahren zu ihrer herstellung - Google Patents
Mikropartikelzusammensetzungen und verfahren zu ihrer herstellungInfo
- Publication number
- ATE350015T1 ATE350015T1 AT01975585T AT01975585T ATE350015T1 AT E350015 T1 ATE350015 T1 AT E350015T1 AT 01975585 T AT01975585 T AT 01975585T AT 01975585 T AT01975585 T AT 01975585T AT E350015 T1 ATE350015 T1 AT E350015T1
- Authority
- AT
- Austria
- Prior art keywords
- antigens
- microparticles
- methods
- lactide
- daltons
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23607700P | 2000-09-28 | 2000-09-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE350015T1 true ATE350015T1 (de) | 2007-01-15 |
Family
ID=22888043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01975585T ATE350015T1 (de) | 2000-09-28 | 2001-09-28 | Mikropartikelzusammensetzungen und verfahren zu ihrer herstellung |
Country Status (14)
Country | Link |
---|---|
US (2) | US6753015B2 (de) |
EP (1) | EP1322292B1 (de) |
JP (2) | JP2004509914A (de) |
CN (2) | CN101428006A (de) |
AT (1) | ATE350015T1 (de) |
AU (2) | AU2001294898B2 (de) |
BR (1) | BR0114304A (de) |
CA (1) | CA2420621C (de) |
DE (1) | DE60125795T2 (de) |
ES (1) | ES2278786T3 (de) |
MX (1) | MXPA03002643A (de) |
RU (1) | RU2257198C2 (de) |
WO (1) | WO2002026212A2 (de) |
ZA (1) | ZA200301743B (de) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6884435B1 (en) * | 1997-01-30 | 2005-04-26 | Chiron Corporation | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
ATE235890T1 (de) * | 1997-01-30 | 2003-04-15 | Chiron Corp | Verwendung von mikropartikeln mit adsorbiertem antigen zur stimulierung der immunabwehr |
EP1154790B1 (de) * | 1999-02-26 | 2004-10-20 | Chiron S.r.l. | Verbesserung der bakterizidaktivität von neisseria antigenen mit cg enthaltende oligonukleotiden |
US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
EP1240331B1 (de) * | 1999-12-22 | 2010-04-07 | Aventis Pasteur Limited | Chlamydia antigene, entsprechende dns fragmente und ihre verwendungen |
ATE378348T1 (de) | 2000-01-14 | 2007-11-15 | Us Health | Oligodeoxynukleotide und ihre verwendung zur induktion einer immunreaktion |
ES2260291T3 (es) * | 2000-09-28 | 2006-11-01 | Chiron Corporation | Microparticulas para la administracion de acidos nucleicos heterologos. |
GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
JP4370161B2 (ja) * | 2001-06-29 | 2009-11-25 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | Hcve1e2ワクチン組成物 |
US7666674B2 (en) | 2001-07-27 | 2010-02-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo |
AU2002361468A1 (en) | 2001-08-14 | 2003-03-18 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human S | Method for rapid generation of mature dendritic cells |
AU2002366710A1 (en) | 2001-12-20 | 2003-07-09 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS |
US8466116B2 (en) | 2001-12-20 | 2013-06-18 | The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of CpG oligodeoxynucleotides to induce epithelial cell growth |
WO2003070909A2 (en) | 2002-02-20 | 2003-08-28 | Chiron Corporation | Microparticles with adsorbed polypeptide-containing molecules |
GB0220194D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
WO2004026453A2 (en) * | 2002-09-06 | 2004-04-01 | Genteric, Inc. | Microcapsules and methods of use |
US8263091B2 (en) | 2002-09-18 | 2012-09-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides |
CA2823937A1 (en) | 2002-10-07 | 2004-04-22 | Novartis Vaccines And Diagnostics, Inc. | Hiv vaccine formulations |
PT2279746E (pt) | 2002-11-15 | 2013-12-09 | Novartis Vaccines & Diagnostic | Proteínas de superfície de neisseria meningitidis |
GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
WO2004060396A2 (en) * | 2002-12-27 | 2004-07-22 | Chiron Corporation | Immunogenic compositions containing phospholpid |
US20050191358A1 (en) * | 2003-01-14 | 2005-09-01 | Derek O' Hagan | Microparticles with adsorbed polynucleotide-containing species |
GB0300881D0 (en) * | 2003-01-15 | 2003-02-12 | Secr Defence | Therapeutic treatment |
AU2004224746B2 (en) * | 2003-03-24 | 2009-04-23 | Valneva Austria Gmbh | Improved vaccines |
NZ543343A (en) * | 2003-04-25 | 2008-03-28 | Novartis Vaccines & Diagnostic | Compositions comprising cationic microparticles and HCV E1E2 DNA and methods of use thereof |
ES2596553T3 (es) * | 2003-06-02 | 2017-01-10 | Glaxosmithkline Biologicals Sa | Composiciones inmunogénicas a base de micropartículas que comprenden toxoide adsorbido y un antígeno que contiene un polisacárido |
GB2407500A (en) * | 2003-11-03 | 2005-05-04 | Ist Superiore Sanita | Use of microparticles for antigen delivery |
US7682009B1 (en) * | 2004-06-01 | 2010-03-23 | Sliwa Jr John W | Cooling, condensation and freezing of atmospheric water or of a microfluidic working-material in or on microfluidic devices |
CA2588089C (en) * | 2004-11-15 | 2015-06-23 | Novartis Vaccines And Diagnostics Inc. | Immunogenic compositions containing anthrax antigen, biodegradable polymer microparticles, and polynucleotide-containing immunological adjuvant |
JP2006169336A (ja) * | 2004-12-15 | 2006-06-29 | Nissan Motor Co Ltd | 情報化核酸含有透明樹脂組成物 |
JP2006169337A (ja) * | 2004-12-15 | 2006-06-29 | Nissan Motor Co Ltd | 不透明樹脂組成物 |
EA014314B1 (ru) * | 2005-08-02 | 2010-10-29 | Новартис Вэксинес Энд Дайэгностикс Срл | Пониженная интерференция между маслосодержащими адъювантами и антигенами, содержащими поверхностно-активные вещества |
ES2564241T3 (es) * | 2005-12-02 | 2016-03-21 | Glaxosmithkline Biologicals Sa | Nanopartículas para su uso en composiciones inmunogénicas |
MX2010003364A (es) | 2007-10-08 | 2010-07-06 | Lux Biosciences Inc | Composiciones oftalmicas que comprenden inhibidores de calcineurina o inhibidores de mtor. |
ES2498091T3 (es) * | 2008-04-28 | 2014-09-24 | Novartis Ag | Procedimiento para producir nanopartículas |
AU2010259184B2 (en) | 2009-06-09 | 2015-08-13 | Aurinia Pharmaceuticals Inc. | Topical drug delivery systems for ophthalmic use |
JP5988435B2 (ja) * | 2010-01-24 | 2016-09-07 | ノバルティス アーゲー | 放射線照射された生分解性微粒子 |
CA2793959C (en) | 2010-03-25 | 2019-06-04 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
AU2011238431B2 (en) * | 2010-04-09 | 2016-10-06 | Reef Pharmaceuticals Pty Ltd | Methods and compositions for inhibiting HIV transmission |
NZ606591A (en) | 2010-07-06 | 2015-02-27 | Novartis Ag | Cationic oil-in-water emulsions |
SI2691530T1 (en) | 2011-06-10 | 2018-08-31 | Oregon Health & Science University | CMV glycoproteins and recombinant vectors |
MX350198B (es) | 2011-07-06 | 2017-08-30 | Novartis Ag | Emulsiones aceite en agua que contienen acidos nucleicos. |
US20130189754A1 (en) | 2011-09-12 | 2013-07-25 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
EP2586461A1 (de) | 2011-10-27 | 2013-05-01 | Christopher L. Parks | Von einem eingehüllten Virus abgeleitete Virenpartikel |
US20140105970A1 (en) * | 2011-12-01 | 2014-04-17 | Flow Pharma, Inc. | Adjuvant and antigen particle formulation |
ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
US11439594B2 (en) | 2012-12-04 | 2022-09-13 | Phosphorex, Inc. | Microparticles and nanoparticles having negative surface charges |
EP2848937A1 (de) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Verfahren zur Identifizierung neuartiger HIV-1-Immunogene |
US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
CN106457302B (zh) | 2014-05-27 | 2020-04-17 | 人工细胞科技公司 | 通过tff进行多层涂覆芯的自动化逐层构造 |
US10174292B2 (en) | 2015-03-20 | 2019-01-08 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
EP3072901A1 (de) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Lösliche hiv-1-hüllglykoproteintrimere |
IL257800B2 (en) * | 2015-09-03 | 2023-11-01 | Novavax Inc | Immune compositions with improved stability and immunogenicity |
US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
US10406102B2 (en) | 2017-07-11 | 2019-09-10 | Sustained Nano Systems Llc | Hypercompressed pharmaceutical formulations |
EP3461857A1 (de) * | 2017-09-28 | 2019-04-03 | Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH | Oberflächenfunktionalisiertes polymerobjekt und verfahren zu dessen herstellung |
US20210154144A1 (en) * | 2018-03-02 | 2021-05-27 | University Of The Sciences | Polymer compositions for storage and release of polypeptides |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL134977C (de) | 1962-07-11 | |||
JPH0832638B2 (ja) | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
US5538739A (en) * | 1989-07-07 | 1996-07-23 | Sandoz Ltd. | Sustained release formulations of water soluble peptides |
FR2695563B1 (fr) | 1992-09-11 | 1994-12-02 | Pasteur Institut | Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires. |
JPH08505625A (ja) | 1993-01-11 | 1996-06-18 | ダナ−ファーバー キャンサー インスティチュート | 細胞毒性tリンパ球応答の誘導 |
GB9311454D0 (en) | 1993-06-03 | 1993-07-21 | Agricultural & Food Res | Pharmaceutical compositions |
US6015686A (en) | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
US5643605A (en) * | 1993-10-25 | 1997-07-01 | Genentech, Inc. | Methods and compositions for microencapsulation of adjuvants |
CA2190121A1 (en) | 1994-03-15 | 1995-09-21 | Edith Mathiowitz | Polymeric gene delivery system |
GB9412273D0 (en) | 1994-06-18 | 1994-08-10 | Univ Nottingham | Administration means |
WO1996020698A2 (en) | 1995-01-05 | 1996-07-11 | The Board Of Regents Acting For And On Behalf Of The University Of Michigan | Surface-modified nanoparticles and method of making and using same |
GB9514285D0 (en) | 1995-07-13 | 1995-09-13 | Univ Nottingham | Polymeric lamellar substrate particles for drug delivery |
JPH09255590A (ja) * | 1996-03-21 | 1997-09-30 | Japan Synthetic Rubber Co Ltd | 徐放性薬剤 |
US6451592B1 (en) | 1996-04-05 | 2002-09-17 | Chiron Corporation | Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis |
DE69738521T2 (de) | 1996-04-05 | 2009-05-07 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Alphaviren-vektors mit einer reduzierten inhibierung der synthese von zellmakromolekülen |
GB9619002D0 (en) | 1996-09-11 | 1996-10-23 | Oxford Biosciences Ltd | Particle delivery |
US6491925B2 (en) * | 1996-08-15 | 2002-12-10 | Emory University | Compositions and methods for cancer prophylaxis and/or treatment |
US5842723A (en) | 1996-11-25 | 1998-12-01 | Burex Automotive America, Inc. | Flexible connection arrangement for connecting a pipe of an exhaust system to an engine, especially in a motor vehicle |
US5783567A (en) | 1997-01-22 | 1998-07-21 | Pangaea Pharmaceuticals, Inc. | Microparticles for delivery of nucleic acid |
ATE235890T1 (de) | 1997-01-30 | 2003-04-15 | Chiron Corp | Verwendung von mikropartikeln mit adsorbiertem antigen zur stimulierung der immunabwehr |
US5840970A (en) * | 1997-10-03 | 1998-11-24 | Eastman Chemical Company | Process for the purification of naphthalenedicarboxylic acid |
PT1042001E (pt) | 1997-12-16 | 2002-09-30 | Chiron Corp | Uso de microparticulas combinadas com emulsoes submicronicas oleo-em-agua |
US6395253B2 (en) * | 1998-04-23 | 2002-05-28 | The Regents Of The University Of Michigan | Microspheres containing condensed polyanionic bioactive agents and methods for their production |
AU763975B2 (en) * | 1998-07-29 | 2003-08-07 | Novartis Vaccines And Diagnostics, Inc. | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
CA2363141C (en) | 1999-02-26 | 2010-04-06 | Chiron Corporation | Microemulsions with adsorbed macromolecules and microparticles |
US20020009466A1 (en) * | 1999-08-31 | 2002-01-24 | David J. Brayden | Oral vaccine compositions |
EP1232267B1 (de) * | 1999-10-27 | 2013-03-20 | Novartis Vaccines and Diagnostics, Inc. | Aktivierung von hcv-spezifischen t-zellen |
WO2001036599A1 (en) | 1999-11-19 | 2001-05-25 | Chiron Corporation | Microparticle-based transfection and activation of dendritic cells |
US20010046967A1 (en) * | 2000-03-10 | 2001-11-29 | Gary Van Nest | Methods of preventing and treating respiratory viral infection using immunomodulatory polynucleotide |
AU2001249380A1 (en) | 2000-03-22 | 2001-11-07 | Chiron Corporation | Compositions and methods for generating an immune response utilizing alphavirus-based vector systems |
-
2001
- 2001-09-28 CN CNA2008101750512A patent/CN101428006A/zh active Pending
- 2001-09-28 EP EP01975585A patent/EP1322292B1/de not_active Expired - Lifetime
- 2001-09-28 CA CA2420621A patent/CA2420621C/en not_active Expired - Fee Related
- 2001-09-28 MX MXPA03002643A patent/MXPA03002643A/es active IP Right Grant
- 2001-09-28 CN CNA018165575A patent/CN1535140A/zh active Pending
- 2001-09-28 ES ES01975585T patent/ES2278786T3/es not_active Expired - Lifetime
- 2001-09-28 JP JP2002530042A patent/JP2004509914A/ja not_active Withdrawn
- 2001-09-28 AT AT01975585T patent/ATE350015T1/de active
- 2001-09-28 BR BR0114304-2A patent/BR0114304A/pt not_active Application Discontinuation
- 2001-09-28 RU RU2003112239/15A patent/RU2257198C2/ru not_active IP Right Cessation
- 2001-09-28 AU AU2001294898A patent/AU2001294898B2/en not_active Ceased
- 2001-09-28 WO PCT/US2001/030541 patent/WO2002026212A2/en active IP Right Grant
- 2001-09-28 AU AU9489801A patent/AU9489801A/xx active Pending
- 2001-09-28 DE DE60125795T patent/DE60125795T2/de not_active Expired - Lifetime
- 2001-09-28 US US09/967,462 patent/US6753015B2/en not_active Expired - Lifetime
-
2003
- 2003-03-03 ZA ZA200301743A patent/ZA200301743B/en unknown
-
2004
- 2004-02-10 US US10/775,964 patent/US7846479B2/en not_active Expired - Fee Related
-
2013
- 2013-05-08 JP JP2013098678A patent/JP2013147514A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2001294898B2 (en) | 2006-02-02 |
JP2004509914A (ja) | 2004-04-02 |
US20040156913A1 (en) | 2004-08-12 |
BR0114304A (pt) | 2003-07-29 |
ZA200301743B (en) | 2004-10-04 |
US7846479B2 (en) | 2010-12-07 |
CA2420621A1 (en) | 2002-04-04 |
CA2420621C (en) | 2011-05-24 |
CN101428006A (zh) | 2009-05-13 |
WO2002026212A3 (en) | 2003-03-27 |
EP1322292A2 (de) | 2003-07-02 |
RU2257198C2 (ru) | 2005-07-27 |
US20020136776A1 (en) | 2002-09-26 |
AU9489801A (en) | 2002-04-08 |
MXPA03002643A (es) | 2003-06-19 |
EP1322292B1 (de) | 2007-01-03 |
CN1535140A (zh) | 2004-10-06 |
US6753015B2 (en) | 2004-06-22 |
JP2013147514A (ja) | 2013-08-01 |
DE60125795D1 (de) | 2007-02-15 |
DE60125795T2 (de) | 2007-10-18 |
WO2002026212A2 (en) | 2002-04-04 |
ES2278786T3 (es) | 2007-08-16 |
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