ES2498091T3 - Procedimiento para producir nanopartículas - Google Patents

Procedimiento para producir nanopartículas Download PDF

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Publication number
ES2498091T3
ES2498091T3 ES09739571.9T ES09739571T ES2498091T3 ES 2498091 T3 ES2498091 T3 ES 2498091T3 ES 09739571 T ES09739571 T ES 09739571T ES 2498091 T3 ES2498091 T3 ES 2498091T3
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ES
Spain
Prior art keywords
nanoparticles
procedure
biodegradable polymer
produce nanoparticles
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09739571.9T
Other languages
English (en)
Inventor
Aravind Chakrapani
Manmohan Singh
Derek T. O'hagan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2498091T3 publication Critical patent/ES2498091T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/14—Powdering or granulating by precipitation from solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers
    • C08J2300/16—Biodegradable polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
    • C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Biological Depolymerization Polymers (AREA)

Abstract

Método de formación de nanopartículas que comprende poner en contacto un primer líquido que comprende un polímero biodegradable disuelto en un disolvente orgánico con un segundo líquido que comprende un disolvente acuoso que comprende un tampón, que es miscible con el disolvente orgánico, al tiempo que es un no disolvente para el polímero biodegradable, en condiciones de agitación suave sin remover de manera que se forman nanopartículas, con lo que el rendimiento del proceso, en base a la cantidad de polímero biodegradable que se recupera en forma de nanopartículas, es del 90% o más y con lo que el valor D(v, 0,5) para las nanopartículas es inferior a 200 nm.

Description

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Claims (1)

  1. imagen1
ES09739571.9T 2008-04-28 2009-04-28 Procedimiento para producir nanopartículas Active ES2498091T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4842808P 2008-04-28 2008-04-28
US48428P 2008-04-28
PCT/US2009/041932 WO2009134769A1 (en) 2008-04-28 2009-04-28 Nanoparticles for use in pharmaceutical compositions

Publications (1)

Publication Number Publication Date
ES2498091T3 true ES2498091T3 (es) 2014-09-24

Family

ID=40792578

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09739571.9T Active ES2498091T3 (es) 2008-04-28 2009-04-28 Procedimiento para producir nanopartículas

Country Status (6)

Country Link
US (1) US9393295B2 (es)
EP (1) EP2282771B1 (es)
JP (2) JP2011518885A (es)
CA (1) CA2722765C (es)
ES (1) ES2498091T3 (es)
WO (1) WO2009134769A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100160368A1 (en) 2008-08-18 2010-06-24 Gregory Jefferson J Methods of Treating Dermatological Disorders and Inducing Interferon Biosynthesis With Shorter Durations of Imiquimod Therapy
PL2378876T3 (pl) 2008-12-19 2019-06-28 Medicis Pharmaceutical Corporation Dawka imikwimodu o mniejszej sile i krótkie schematy dawkowania w leczeniu rogowacenia słonecznego
MX336923B (es) 2009-07-13 2016-02-05 Medicis Pharmaceutical Corp Formulaciones de imiquimod de concentracion de dosificacion inferior y regimenes de dosificacion cortos para tratar verrugas genitales y perianales.
WO2011093043A1 (ja) * 2010-01-27 2011-08-04 国立大学法人北海道大学 回折顕微法
WO2012164480A1 (en) * 2011-05-30 2012-12-06 National Institute Of Immunology A vaccine composition capable of inducing memory antibody response from single point immunization
JPWO2012169518A1 (ja) * 2011-06-07 2015-02-23 ホソカワミクロン株式会社 液状組成物及びそれを用いた化粧料並びに育毛剤
US20130122106A1 (en) * 2011-10-19 2013-05-16 Aphios Corporation Dosage form, and methods of making and using the same, to produce immunization in animals and humans
WO2013163337A1 (en) * 2012-04-24 2013-10-31 The Ohio State University Compositions and methods for treating and preventing porcine reproductive and respiratory syndrome
KR101732760B1 (ko) * 2013-10-10 2017-05-24 주식회사 엘지화학 폴리락트산 입자의 제조방법
US10280199B2 (en) 2014-02-07 2019-05-07 Phibro Animal Health Corporation Coronavirus proteins and antigens
US10117886B2 (en) * 2014-05-30 2018-11-06 Hao Cheng Hyaluronidase and a low density second PEG layer on the surface of therapeutic-encapsulated nanoparticles to enhance nanoparticle diffusion and circulation
US10279031B2 (en) 2016-05-11 2019-05-07 Phibro Animal Health Corporation Composition comprising antigens and a mucosal adjuvant and a method for using
WO2017196318A1 (en) * 2016-05-11 2017-11-16 Phibro Animal Health Corporation A composition comprising antigens and a mucosal adjuvant and a method for using
WO2018009672A1 (en) 2016-07-06 2018-01-11 University Of Maryland, College Park Polyphosphazene polyelectrolytes and uses thereof
WO2025064543A1 (en) * 2023-09-20 2025-03-27 University Of Washington Bacterial cellulose derived nanoparticles and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0829246B2 (ja) * 1986-10-01 1996-03-27 三菱製紙株式会社 マイクロカプセルの製造方法
FR2608988B1 (fr) 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules
FR2634397B2 (fr) 1986-12-31 1991-04-19 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une proteine sous forme de nanoparticules
FR2608942B1 (fr) 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
ATE252894T1 (de) * 1995-01-05 2003-11-15 Univ Michigan Oberflächen-modifizierte nanopartikel und verfahren für ihre herstellung und verwendung
GB9514285D0 (en) 1995-07-13 1995-09-13 Univ Nottingham Polymeric lamellar substrate particles for drug delivery
US6143211A (en) 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
US6884435B1 (en) 1997-01-30 2005-04-26 Chiron Corporation Microparticles with adsorbent surfaces, methods of making same, and uses thereof
NZ509853A (en) 1998-07-29 2003-08-29 Chiron Corp Microparticles with an adsorbent surface useful for delivering pharmaceuticals
AU9489801A (en) 2000-09-28 2002-04-08 Chiron Corp Microparticle compositions and methods for the manufacture thereof
DK1322287T3 (da) 2000-09-28 2006-07-24 Chiron Corp Mikropartikler til administration af heterologe nukleinsyrer
US20050191358A1 (en) * 2003-01-14 2005-09-01 Derek O' Hagan Microparticles with adsorbed polynucleotide-containing species
ES2564241T3 (es) 2005-12-02 2016-03-21 Glaxosmithkline Biologicals Sa Nanopartículas para su uso en composiciones inmunogénicas
JP2009527572A (ja) 2006-02-24 2009-07-30 ノバルティス アーゲー 免疫原性組成物に使用するための生分解性ポリマーおよびカチオン性多糖を含むミクロ粒子
DK2644192T3 (en) * 2007-09-28 2017-06-26 Pfizer Cancer cell targeting using nanoparticles

Also Published As

Publication number Publication date
JP2015057444A (ja) 2015-03-26
WO2009134769A1 (en) 2009-11-05
CA2722765C (en) 2016-10-04
EP2282771B1 (en) 2014-06-25
US20110038900A1 (en) 2011-02-17
JP2011518885A (ja) 2011-06-30
US9393295B2 (en) 2016-07-19
EP2282771A1 (en) 2011-02-16
CA2722765A1 (en) 2009-11-05

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