BR0114304A - Composições de micropartìculas e métodos para a manufatura das mesmas - Google Patents

Composições de micropartìculas e métodos para a manufatura das mesmas

Info

Publication number
BR0114304A
BR0114304A BR0114304-2A BR0114304A BR0114304A BR 0114304 A BR0114304 A BR 0114304A BR 0114304 A BR0114304 A BR 0114304A BR 0114304 A BR0114304 A BR 0114304A
Authority
BR
Brazil
Prior art keywords
antigens
microparticles
methods
lactide
daltons
Prior art date
Application number
BR0114304-2A
Other languages
English (en)
Inventor
Jia-Hwa Fang
Maninder Hora
Derek O'hagan
Manmohan Singh
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of BR0114304A publication Critical patent/BR0114304A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"COMPOSIçõES DE MICROPARTìCULAS E MéTODOS PARA A MANUFATURA DAS MESMAS". Micropartículas com complexos adsorvidos de macromolécula e detergente, métodos de fazer tais micropartículas, e usos dos mesmos, são descritos. As micropartículas compreendem um polímero, tal como um poli( -hidróxi ácido), um ácido polihidróxi butírico, uma policaprolactona, um poliortoéster, um polianidrido, e similares, e são formados usando detergentes catiónicos, aniónicos, ou não iónicos. As superfícies das micropartículas têm adsorvidas nelas um complexo de macromoléculas biologicamente ativas, tais como ácidos nucléicos, polipeptídeos, antígenos, e adjuvantes, e um detergente. Polímeros preferidos são poli (D, L-lactídeo-co-glicolídeos), mais particularmente aqueles tendo uma razão molar de lactídeo/glicolídeo variando de 40:60 a 60:40 e tendo um peso molecular variando de 30.000 Daltons a 70.000 Daltons. Macromoléculas preferidas são bacterianas e antígenos antivirais (tal como antígenos de HIV, antígenos de meningite B, antígenos de estreptococus, e antígenos de hemaglutinina de Influenza A) assim como polinucleotídeos que codificam tais antígenos.
BR0114304-2A 2000-09-28 2001-09-28 Composições de micropartìculas e métodos para a manufatura das mesmas BR0114304A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23607700P 2000-09-28 2000-09-28
PCT/US2001/030541 WO2002026212A2 (en) 2000-09-28 2001-09-28 Microparticle compositions and methods for the manufacture thereof

Publications (1)

Publication Number Publication Date
BR0114304A true BR0114304A (pt) 2003-07-29

Family

ID=22888043

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0114304-2A BR0114304A (pt) 2000-09-28 2001-09-28 Composições de micropartìculas e métodos para a manufatura das mesmas

Country Status (14)

Country Link
US (2) US6753015B2 (pt)
EP (1) EP1322292B1 (pt)
JP (2) JP2004509914A (pt)
CN (2) CN1535140A (pt)
AT (1) ATE350015T1 (pt)
AU (2) AU2001294898B2 (pt)
BR (1) BR0114304A (pt)
CA (1) CA2420621C (pt)
DE (1) DE60125795T2 (pt)
ES (1) ES2278786T3 (pt)
MX (1) MXPA03002643A (pt)
RU (1) RU2257198C2 (pt)
WO (1) WO2002026212A2 (pt)
ZA (1) ZA200301743B (pt)

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Also Published As

Publication number Publication date
DE60125795T2 (de) 2007-10-18
CA2420621C (en) 2011-05-24
JP2004509914A (ja) 2004-04-02
ES2278786T3 (es) 2007-08-16
EP1322292A2 (en) 2003-07-02
JP2013147514A (ja) 2013-08-01
CA2420621A1 (en) 2002-04-04
RU2257198C2 (ru) 2005-07-27
ZA200301743B (en) 2004-10-04
EP1322292B1 (en) 2007-01-03
AU9489801A (en) 2002-04-08
US20020136776A1 (en) 2002-09-26
DE60125795D1 (de) 2007-02-15
ATE350015T1 (de) 2007-01-15
US20040156913A1 (en) 2004-08-12
WO2002026212A3 (en) 2003-03-27
CN1535140A (zh) 2004-10-06
MXPA03002643A (es) 2003-06-19
US7846479B2 (en) 2010-12-07
WO2002026212A2 (en) 2002-04-04
US6753015B2 (en) 2004-06-22
CN101428006A (zh) 2009-05-13
AU2001294898B2 (en) 2006-02-02

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Legal Events

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B25D Requested change of name of applicant approved

Owner name: NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US)

Free format text: ALTERADO DE: CHIRON CORPORATION

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]