CO5540367A2 - Composicion de liberacion controlada y metodo para producirla - Google Patents

Composicion de liberacion controlada y metodo para producirla

Info

Publication number
CO5540367A2
CO5540367A2 CO03111729A CO03111729A CO5540367A2 CO 5540367 A2 CO5540367 A2 CO 5540367A2 CO 03111729 A CO03111729 A CO 03111729A CO 03111729 A CO03111729 A CO 03111729A CO 5540367 A2 CO5540367 A2 CO 5540367A2
Authority
CO
Colombia
Prior art keywords
salt
controlled release
composition
weight
active substance
Prior art date
Application number
CO03111729A
Other languages
English (en)
Inventor
Yamamoto Kazumichi
Akiko Yamada
Hata Yoshio
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26617910&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5540367(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of CO5540367A2 publication Critical patent/CO5540367A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)
  • Lubricants (AREA)

Abstract

1.- Una composición de liberación controlada que comprende (1) una sustancia fisiológicamente activa o una sal de la misma en una cantidad de aproximadamente el 14 % (p/p) a aproximadamente el 24 % (p/p) en base al peso total de la composición, (2) ácido hidroxinaftoico seleccionado del grupo que consiste en ácido 3-hidroxi-2-naftoico y ácido 1-hidroxi-2-naftoico o sal del mismo, y (3) un polímero de ácido láctico o una sal del mismo que tiene un peso molecular medio en peso de 15000 a 50000 en donde el contenido de los polímeros que tienen pesos moleculares de 5000 ó menos es de aproximadamente el 5 % en peso o menos, donde la relación molar de dicho ácido hidroxinaftoico o una sal del mismo respecto de dicha sustancia fisiológicamente activa o una sal de la misma es de 3:4 a 4:3.2.- La composición de liberación controlada de acuerdo con la reivindicación 1, donde el polímero de ácido láctico tiene un peso molecular medio en peso de 15000 a 30000.3.- La composición de liberación controlada de acuerdo con la reivindicación 1, donde la sustancia fisiológicamente activa es un derivado de la LH-RH.
CO03111729A 2001-06-29 2003-12-22 Composicion de liberacion controlada y metodo para producirla CO5540367A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001199484 2001-06-29
JP2001340993 2001-11-06

Publications (1)

Publication Number Publication Date
CO5540367A2 true CO5540367A2 (es) 2005-07-29

Family

ID=26617910

Family Applications (1)

Application Number Title Priority Date Filing Date
CO03111729A CO5540367A2 (es) 2001-06-29 2003-12-22 Composicion de liberacion controlada y metodo para producirla

Country Status (34)

Country Link
US (4) US7429559B2 (es)
EP (3) EP1330293B2 (es)
JP (5) JP2003206240A (es)
KR (2) KR100916173B1 (es)
CN (3) CN100348265C (es)
AR (2) AR034641A1 (es)
AT (3) ATE326264T1 (es)
AU (2) AU2002311631B2 (es)
BR (1) BRPI0210561B8 (es)
CA (1) CA2455392C (es)
CO (1) CO5540367A2 (es)
CR (1) CR11283A (es)
CY (2) CY1105071T1 (es)
CZ (1) CZ306327B6 (es)
DE (2) DE60225481T2 (es)
DK (2) DK1949936T3 (es)
ES (2) ES2366677T3 (es)
HK (1) HK1056332A1 (es)
HU (1) HU230351B1 (es)
IL (3) IL159059A0 (es)
MX (1) MXPA03011456A (es)
MY (1) MY142066A (es)
NO (1) NO331883B1 (es)
NZ (2) NZ529969A (es)
PE (1) PE20030066A1 (es)
PL (1) PL204903B1 (es)
PT (2) PT1330293E (es)
RU (1) RU2301661C2 (es)
SG (1) SG180015A1 (es)
SI (1) SI1949936T1 (es)
SK (1) SK287577B6 (es)
TW (2) TW200526267A (es)
WO (1) WO2003002092A2 (es)
ZA (1) ZA200309152B (es)

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Also Published As

Publication number Publication date
US7429559B2 (en) 2008-09-30
HUP0400378A2 (hu) 2004-12-28
IL159059A0 (en) 2004-05-12
US8246987B2 (en) 2012-08-21
JP2010189428A (ja) 2010-09-02
EP1949936A3 (en) 2008-10-08
EP1491236B1 (en) 2008-03-05
DE60211464D1 (de) 2006-06-22
HUP0400378A3 (en) 2010-01-28
HU230351B1 (hu) 2016-02-29
NO20035738L (no) 2004-02-27
ES2263788T3 (es) 2006-12-16
WO2003002092A2 (en) 2003-01-09
IL186782A0 (en) 2008-02-09
DK1330293T4 (da) 2011-01-10
EP1491236A1 (en) 2004-12-29
PL204903B1 (pl) 2010-02-26
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KR100916173B1 (ko) 2009-09-08
JP2009167203A (ja) 2009-07-30
DK1949936T3 (da) 2011-08-15
EP1330293B1 (en) 2006-05-17
DK1330293T3 (da) 2006-09-11
KR20040018402A (ko) 2004-03-03
CY1111708T1 (el) 2015-10-07
US20110166084A1 (en) 2011-07-07
AU2002311631B2 (en) 2007-02-08
SI1949936T1 (sl) 2011-08-31
KR20090020708A (ko) 2009-02-26
ES2366677T3 (es) 2011-10-24
AR098261A2 (es) 2016-05-18
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NO331883B1 (no) 2012-04-23
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ATE387937T1 (de) 2008-03-15
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AU2006246508B2 (en) 2008-09-04
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CN1724066A (zh) 2006-01-25
DE60225481D1 (de) 2008-04-17
DE60211464T3 (de) 2011-03-17
PT1330293E (pt) 2006-08-31
US20090005318A1 (en) 2009-01-01
CN1292796C (zh) 2007-01-03
DE60225481T2 (de) 2009-02-26
US20120283187A1 (en) 2012-11-08
SK287577B6 (sk) 2011-03-04
ATE326264T1 (de) 2006-06-15
TWI332407B (en) 2010-11-01
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RU2004102507A (ru) 2005-03-10
WO2003002092A3 (en) 2003-04-10
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KR100961413B1 (ko) 2010-06-09

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