DE602006003848D1 - Formulierung zur verzögerten Freisetzung von Valproinsäure und deren Derivate - Google Patents
Formulierung zur verzögerten Freisetzung von Valproinsäure und deren DerivateInfo
- Publication number
- DE602006003848D1 DE602006003848D1 DE602006003848T DE602006003848T DE602006003848D1 DE 602006003848 D1 DE602006003848 D1 DE 602006003848D1 DE 602006003848 T DE602006003848 T DE 602006003848T DE 602006003848 T DE602006003848 T DE 602006003848T DE 602006003848 D1 DE602006003848 D1 DE 602006003848D1
- Authority
- DE
- Germany
- Prior art keywords
- formulation
- valproic acid
- derivatives
- sustained release
- polymers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06250124A EP1815850B1 (de) | 2006-01-11 | 2006-01-11 | Formulierung zur verzögerten Freisetzung von Valproinsäure und deren Derivate |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006003848D1 true DE602006003848D1 (de) | 2009-01-08 |
Family
ID=36250729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006003848T Active DE602006003848D1 (de) | 2006-01-11 | 2006-01-11 | Formulierung zur verzögerten Freisetzung von Valproinsäure und deren Derivate |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1815850B1 (de) |
AT (1) | ATE415151T1 (de) |
DE (1) | DE602006003848D1 (de) |
DK (1) | DK1815850T3 (de) |
ES (1) | ES2317450T3 (de) |
PL (1) | PL1815850T3 (de) |
PT (1) | PT1815850E (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201417828D0 (en) | 2014-10-08 | 2014-11-19 | Cereno Scient Ab | New methods and compositions |
CN114209667A (zh) * | 2016-04-08 | 2022-03-22 | 赛伦诺科技有限公司 | 包含丙戊酸的延迟释放药物制剂和其用途 |
CN107811985B (zh) * | 2016-09-13 | 2021-05-28 | 四川科瑞德制药股份有限公司 | 一种抗癫痫缓释制剂及其制备方法与用途 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5212326A (en) | 1979-08-20 | 1993-05-18 | Abbott Laboratories | Sodium hydrogen divalproate oligomer |
US4988731A (en) | 1979-08-20 | 1991-01-29 | Abbott Laboratories | Sodium hydrogen divalproate oligomer |
US4369172A (en) | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
US5185159A (en) | 1983-07-20 | 1993-02-09 | Sanofi | Pharmaceutical composition based on valproic acid and a process for preparing it |
US4913906B1 (en) | 1985-02-28 | 2000-06-06 | Yissum Res Dev Co | Controlled release dosage form of valproic acid |
ATE68346T1 (de) * | 1987-07-22 | 1991-11-15 | Farvalsa Ag | Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung. |
GB8724763D0 (en) | 1987-10-22 | 1987-11-25 | Aps Research Ltd | Sustained-release formulations |
US5009897A (en) | 1988-06-24 | 1991-04-23 | Abbott Laboratories | Pharmaceutical granules and tablets made therefrom |
US5169642A (en) | 1988-06-24 | 1992-12-08 | Abbott Laboratories | Sustained-release drug dosage units |
FR2643556B1 (fr) | 1989-02-27 | 1993-03-05 | Sanofi Sa | Composition pharmaceutique a liberation prolongee d'acide valproique |
EP0571973B1 (de) | 1992-05-29 | 2000-02-02 | Nikken Chemicals Co., Ltd. | Tablette zur langsamen Freisetzung von Natriumvalproat |
US6287598B1 (en) * | 1993-05-28 | 2001-09-11 | Alza Corporation | Method for providing sustained antiepileptic therapy |
US6528090B2 (en) | 1998-12-18 | 2003-03-04 | Abbott Laboratories | Controlled release formulation of divalproex sodium |
US6419953B1 (en) | 1998-12-18 | 2002-07-16 | Abbott Laboratories | Controlled release formulation of divalproex sodium |
AT408718B (de) * | 1999-12-02 | 2002-02-25 | Gerot Pharmazeutika | Natriumvalproat-granulat mit verringerter hygroskopizität |
-
2006
- 2006-01-11 PL PL06250124T patent/PL1815850T3/pl unknown
- 2006-01-11 DE DE602006003848T patent/DE602006003848D1/de active Active
- 2006-01-11 AT AT06250124T patent/ATE415151T1/de not_active IP Right Cessation
- 2006-01-11 PT PT06250124T patent/PT1815850E/pt unknown
- 2006-01-11 DK DK06250124T patent/DK1815850T3/da active
- 2006-01-11 ES ES06250124T patent/ES2317450T3/es active Active
- 2006-01-11 EP EP06250124A patent/EP1815850B1/de active Active
Also Published As
Publication number | Publication date |
---|---|
ATE415151T1 (de) | 2008-12-15 |
EP1815850A1 (de) | 2007-08-08 |
PL1815850T3 (pl) | 2009-05-29 |
EP1815850B1 (de) | 2008-11-26 |
PT1815850E (pt) | 2009-01-06 |
ES2317450T3 (es) | 2009-04-16 |
DK1815850T3 (da) | 2009-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |