ATE68346T1 - Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung. - Google Patents

Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung.

Info

Publication number
ATE68346T1
ATE68346T1 AT87810611T AT87810611T ATE68346T1 AT E68346 T1 ATE68346 T1 AT E68346T1 AT 87810611 T AT87810611 T AT 87810611T AT 87810611 T AT87810611 T AT 87810611T AT E68346 T1 ATE68346 T1 AT E68346T1
Authority
AT
Austria
Prior art keywords
weight percent
valproic acid
moisture
stable solid
production
Prior art date
Application number
AT87810611T
Other languages
English (en)
Inventor
Aracelis M Dr Ortega
Perez Pilar Martin Dr De
Margarita De
Original Assignee
Farvalsa Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farvalsa Ag filed Critical Farvalsa Ag
Application granted granted Critical
Publication of ATE68346T1 publication Critical patent/ATE68346T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT87810611T 1987-07-22 1987-10-23 Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung. ATE68346T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7663487A 1987-07-22 1987-07-22
EP87810611A EP0300111B1 (de) 1987-07-22 1987-10-23 Feuchtigkeitsstabile feste Valproinsäure-Zubereitung und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ATE68346T1 true ATE68346T1 (de) 1991-11-15

Family

ID=22133265

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87810611T ATE68346T1 (de) 1987-07-22 1987-10-23 Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung.

Country Status (6)

Country Link
US (1) US5049586A (de)
EP (1) EP0300111B1 (de)
AT (1) ATE68346T1 (de)
DE (1) DE3773926D1 (de)
ES (1) ES2026198T3 (de)
GR (1) GR3003187T3 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR1002098B (en) * 1989-06-08 1995-12-28 Squibb & Sons Inc Pharmaceutical composition having good stability
AU653203B2 (en) * 1991-01-30 1994-09-22 Wellcome Foundation Limited, The Water-dispersible tablets
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
US20040191314A1 (en) * 1994-04-28 2004-09-30 Frank Jao Antiepileptic dosage form and process for protecting antiepileptic drug
ZA953078B (en) * 1994-04-28 1996-01-05 Alza Corp Effective therapy for epilepsies
US5681854A (en) * 1995-11-22 1997-10-28 Alcon Laboratories, Inc. Use of aliphatic carboxylic acid derivatives in ophthalmic disorders
CN1063971C (zh) * 1997-09-24 2001-04-04 中国兽药监察所 一种动物用冻干活疫苗制造方法
US6300328B1 (en) 1999-08-06 2001-10-09 Alcon Universal Ltd. Selective inhibitors of adenosine monophosphate deaminase for the treatment of optic nerve and retinal damage
EP1250128A2 (de) * 1999-12-16 2002-10-23 Alcon, Inc. Adenosinekinaseinhibitoren zur behandlung von schädungen des sehnervs und der retina
US20020143058A1 (en) 2001-01-24 2002-10-03 Taro Pharmaceutical Inductries Ltd. Process for preparing non-hygroscopic sodium valproate composition
US20040105886A1 (en) * 2001-02-16 2004-06-03 Chih-Ming Chen Divalproex sodium tablets
US6610326B2 (en) 2001-02-16 2003-08-26 Andrx Corporation Divalproex sodium tablets
ATE540129T1 (de) 2002-11-22 2012-01-15 Univ Johns Hopkins Target zur therapie kognitiver behinderungen
MXPA05005937A (es) 2002-12-06 2005-08-18 Alcon Inc Imitaciones de superoxido de dismutasa para el tratamiento de trastornos y enfermedades oculares.
US20040176463A1 (en) * 2003-02-05 2004-09-09 Daniella Licht Immediate release formulation of n-(2-propylpentanoyl)glycinamide
CN1889961A (zh) * 2003-12-11 2007-01-03 爱尔康公司 用于治疗视神经和视网膜损伤的超氧化物歧化酶拟似物
US7713550B2 (en) * 2004-06-15 2010-05-11 Andrx Corporation Controlled release sodium valproate formulation
US20050276849A1 (en) * 2004-06-15 2005-12-15 Nilobon Podhipleux Sustained release dosage forms
US20070048379A1 (en) * 2005-08-29 2007-03-01 Mintong Guo Valproate tablet
CA2635949A1 (en) * 2006-01-11 2007-07-19 Teva Pharmaceutical Industries Ltd. Controlled release formulation of divalproic acid and its derivatives
US20070160667A1 (en) * 2006-01-11 2007-07-12 Nava Shterman Controlled release formulation of divalproex sodium
ATE415151T1 (de) * 2006-01-11 2008-12-15 Teva Pharma Formulierung zur verzögerten freisetzung von valproinsäure und deren derivate
WO2007101204A1 (en) * 2006-02-27 2007-09-07 Alcon Research, Ltd. Method of treating glaucoma
WO2008001151A1 (en) * 2006-06-29 2008-01-03 Wockhardt Limited Controlled release compositions of divalproex sodium
EP2254630A1 (de) * 2008-02-20 2010-12-01 Boehringer Ingelheim International GmbH Pulverinhalatoren
US20090235929A1 (en) * 2008-03-19 2009-09-24 Marc Egen Powder inhalers
DK2346500T3 (en) * 2008-10-16 2017-07-17 Univ Johns Hopkins Methods and compositions for improving cognitive function
EP2533645B1 (de) * 2010-02-09 2016-07-27 The Johns Hopkins University Verfahren und zusammensetzungen zur verbesserung von kognitiven funktionen
AU2012226586B2 (en) * 2011-03-09 2017-04-13 Cereno Scientific Ab Compounds and methods for improving impaired endogenous fibrinolysis using histone deacetylase inhibitors
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
EP2968237A4 (de) 2013-03-15 2016-08-31 Univ Johns Hopkins Verfahren und zusammensetzungen zur verbesserung der kognitiven funktion
EP2968220B1 (de) 2013-03-15 2021-05-05 Agenebio, Inc. Verfahren und zusammensetzungen zur verbesserung von kognitiven funktionen
GB201417828D0 (en) 2014-10-08 2014-11-19 Cereno Scient Ab New methods and compositions
MX384391B (es) 2015-05-22 2025-03-14 Agenebio Inc Composiciones farmacéuticas de levetiracetam de liberación extendida.
RU2760304C2 (ru) 2016-04-08 2021-11-23 Серено Сайентифик Аб Фармацевтические составы с отсроченным высвобождением, содержащие вальпроевую кислоту, и их применение

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL32673A (en) * 1968-08-05 1973-11-28 Ciba Geigy Ag A granular material containing oily or liquid therapeutically usable furanosides and a process for its manufacture
US4301176A (en) * 1980-08-18 1981-11-17 Warner-Lambert Company Method of administering calcium valproate
NL8600050A (nl) * 1986-01-13 1987-08-03 Sanico Nv Farmaceutisch preparaat met vertraagde afgifte van het werkzame bestanddeel en werkwijze voor de bereiding er van.

Also Published As

Publication number Publication date
DE3773926D1 (de) 1991-11-21
ES2026198T3 (es) 1992-04-16
US5049586A (en) 1991-09-17
EP0300111B1 (de) 1991-10-16
EP0300111A1 (de) 1989-01-25
GR3003187T3 (en) 1993-02-17

Similar Documents

Publication Publication Date Title
ATE68346T1 (de) Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung.
HUT49358A (en) Process for producing phosphorous compounds, pharmaceutical compositions comprising same as active ingredient and intermediaries
ATE48943T1 (de) Feste arzneizubereitung enthaltend nitrendipin und verfahren zur ihrer herstellung.
GB2143734A (en) Process for the preparation of sustained release pharmaceutical compositions having a high active ingredient content
PH25376A (en) Oral sustained release acetaminophen formulation, process
HUT61989A (en) Process for producing 2-deoxy-2,3-didehydro-n-acetylneuraminic acid derivatives and analogs, as well as pharmaceutical compositions comprising same as active ingredient
HUT60740A (en) Process for producing new thiophnecarboxylic acid esters of amino-alcohols, their quaternary derivatives and pharmaceutical compositions comprising same as active ingredient
HUT46531A (en) Process for producing retard tabletted pharmaceutical compositions
HUT50467A (en) Process for producing 7-/1-azetidinyl/-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid derivatives and pharmaceutical compositions containing them as active components
HUT51485A (en) Process for production of immune-hindering, monoquin, especially internuclein-1-hindering medical compositions
HUT47865A (en) Process for producing pharmaceutical compositions containing somatostatin as active component
HUT52952A (en) Process for producing long-acting gemfibrosyl compositions
HUT48902A (en) Process for producing new ribofuranuronic acid derivatives and pharmaceutical compositions containing them
CS405391A3 (en) N-aminobutyl-n-phenylarylamide derivatives, process of their preparationand pharmaceutical compositions containing said derivatives
HUT50334A (en) Process for producing arylpiperazinyl-alkilenephenyl-p-heterocycluc compounds, pharmaceutically acceptable acid addition salts thereof and pharmaceutical compositions comprising the compounds as active ingredient
HUT50112A (en) Process for producing phenoxyalkyl-carboxylic acid derivatives and pharmaceutical compositions containing them as active component
HUT49053A (en) Process for producing pharmaceutical composition comprising comt inhibitor as active ingredient and having action on gastrointestinal tract
DE3274185D1 (en) Medicinal preparations for glycoside-hydrolase inhibitors
HUT49361A (en) Process for producing piperazinecarboxylic acid derivative and pharmaceutical compositions comprising this compound
HUT54166A (en) Process for producing 1,1-dioxocefem-4-carbothiol acid derivatives and pharmaceutical compositions comprising same as active ingredient
PT88634A (pt) A process for the preparation of catechol carboxylic acid derivatives and of pharmaceutical compositions containing the same
HUT48613A (en) Process for producing carbamoyloxylabdane derivatives, their intermediaries and pharmaceutical compositions comprising such compounds as active ingredient
DE59010710D1 (de) Modifizierte Stärke und Verfahren zu ihrer Herstellung
ZA893330B (en) Process for preparing bodies containing a peroxy acid compound and compositions comprising said bodies
EP0383481A3 (de) Bukkale Anästhetika

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee