ATE68346T1 - Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung. - Google Patents
Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung.Info
- Publication number
- ATE68346T1 ATE68346T1 AT87810611T AT87810611T ATE68346T1 AT E68346 T1 ATE68346 T1 AT E68346T1 AT 87810611 T AT87810611 T AT 87810611T AT 87810611 T AT87810611 T AT 87810611T AT E68346 T1 ATE68346 T1 AT E68346T1
- Authority
- AT
- Austria
- Prior art keywords
- weight percent
- valproic acid
- moisture
- stable solid
- production
- Prior art date
Links
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 title abstract 8
- 229960000604 valproic acid Drugs 0.000 title abstract 4
- 239000007787 solid Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000009472 formulation Methods 0.000 abstract 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229920002261 Corn starch Polymers 0.000 abstract 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
- 239000008120 corn starch Substances 0.000 abstract 1
- 239000007884 disintegrant Substances 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 239000000395 magnesium oxide Substances 0.000 abstract 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 abstract 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7663487A | 1987-07-22 | 1987-07-22 | |
EP87810611A EP0300111B1 (de) | 1987-07-22 | 1987-10-23 | Feuchtigkeitsstabile feste Valproinsäure-Zubereitung und Verfahren zu ihrer Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE68346T1 true ATE68346T1 (de) | 1991-11-15 |
Family
ID=22133265
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT87810611T ATE68346T1 (de) | 1987-07-22 | 1987-10-23 | Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung. |
Country Status (6)
Country | Link |
---|---|
US (1) | US5049586A (de) |
EP (1) | EP0300111B1 (de) |
AT (1) | ATE68346T1 (de) |
DE (1) | DE3773926D1 (de) |
ES (1) | ES2026198T3 (de) |
GR (1) | GR3003187T3 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR1002098B (en) * | 1989-06-08 | 1995-12-28 | Squibb & Sons Inc | Pharmaceutical composition having good stability |
US5629016A (en) * | 1991-01-30 | 1997-05-13 | Glaxo Wellcome Inc. | Water-dispersible tablets |
PL169106B1 (pl) * | 1991-01-30 | 1996-06-28 | Wellcome Found | Sposób wytwarzania dyspergowalnej w wodzie tabletki PL PL PL PL PL PL PL |
GB9215908D0 (en) * | 1992-07-27 | 1992-09-09 | Wellcome Found | Water dispersible tablets |
US5698226A (en) * | 1993-07-13 | 1997-12-16 | Glaxo Wellcome Inc. | Water-dispersible tablets |
ZA953078B (en) * | 1994-04-28 | 1996-01-05 | Alza Corp | Effective therapy for epilepsies |
US20040191314A1 (en) * | 1994-04-28 | 2004-09-30 | Frank Jao | Antiepileptic dosage form and process for protecting antiepileptic drug |
US5681854A (en) * | 1995-11-22 | 1997-10-28 | Alcon Laboratories, Inc. | Use of aliphatic carboxylic acid derivatives in ophthalmic disorders |
CN1063971C (zh) * | 1997-09-24 | 2001-04-04 | 中国兽药监察所 | 一种动物用冻干活疫苗制造方法 |
US6300328B1 (en) | 1999-08-06 | 2001-10-09 | Alcon Universal Ltd. | Selective inhibitors of adenosine monophosphate deaminase for the treatment of optic nerve and retinal damage |
JP2003516962A (ja) * | 1999-12-16 | 2003-05-20 | アルコン,インコーポレイテッド | 視神経損傷および網膜損傷の処置のためのアデノシンキナーゼのインヒビター |
US20020143058A1 (en) | 2001-01-24 | 2002-10-03 | Taro Pharmaceutical Inductries Ltd. | Process for preparing non-hygroscopic sodium valproate composition |
US6610326B2 (en) | 2001-02-16 | 2003-08-26 | Andrx Corporation | Divalproex sodium tablets |
US20040105886A1 (en) * | 2001-02-16 | 2004-06-03 | Chih-Ming Chen | Divalproex sodium tablets |
CN1829804A (zh) | 2002-11-22 | 2006-09-06 | 约翰斯·霍普金斯大学 | 治疗认知功能障碍的靶位 |
MXPA05005937A (es) | 2002-12-06 | 2005-08-18 | Alcon Inc | Imitaciones de superoxido de dismutasa para el tratamiento de trastornos y enfermedades oculares. |
US20040176463A1 (en) * | 2003-02-05 | 2004-09-09 | Daniella Licht | Immediate release formulation of n-(2-propylpentanoyl)glycinamide |
CN1889961A (zh) * | 2003-12-11 | 2007-01-03 | 爱尔康公司 | 用于治疗视神经和视网膜损伤的超氧化物歧化酶拟似物 |
US7713550B2 (en) * | 2004-06-15 | 2010-05-11 | Andrx Corporation | Controlled release sodium valproate formulation |
US20050276849A1 (en) * | 2004-06-15 | 2005-12-15 | Nilobon Podhipleux | Sustained release dosage forms |
US20070048379A1 (en) * | 2005-08-29 | 2007-03-01 | Mintong Guo | Valproate tablet |
JP2009525953A (ja) * | 2006-01-11 | 2009-07-16 | テバ ファーマシューティカル インダストリーズ リミティド | ジバルプロ酸及びその誘導体の徐放性製剤 |
US20070160667A1 (en) * | 2006-01-11 | 2007-07-12 | Nava Shterman | Controlled release formulation of divalproex sodium |
DE602006003848D1 (de) * | 2006-01-11 | 2009-01-08 | Teva Pharma | Formulierung zur verzögerten Freisetzung von Valproinsäure und deren Derivate |
WO2007101204A1 (en) * | 2006-02-27 | 2007-09-07 | Alcon Research, Ltd. | Method of treating glaucoma |
WO2008001151A1 (en) * | 2006-06-29 | 2008-01-03 | Wockhardt Limited | Controlled release compositions of divalproex sodium |
WO2009103336A1 (de) * | 2008-02-20 | 2009-08-27 | Boehringer Ingelheim International Gmbh | Pulverinhalatoren |
US20090235929A1 (en) * | 2008-03-19 | 2009-09-24 | Marc Egen | Powder inhalers |
EA033130B1 (ru) | 2008-10-16 | 2019-08-30 | Дзе Джонс Хопкинс Юниверсити | Способы и композиции для улучшения когнитивной функции |
US20110212928A1 (en) * | 2010-02-09 | 2011-09-01 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
EP2919788A4 (de) | 2012-11-14 | 2016-05-25 | Univ Johns Hopkins | Verfahren und zusammensetzungen zur behandlung von schizophrenie |
ES2881081T3 (es) | 2013-03-15 | 2021-11-26 | Agenebio Inc | Procedimientos y composiciones para mejorar la función cognitiva |
US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
GB201417828D0 (en) | 2014-10-08 | 2014-11-19 | Cereno Scient Ab | New methods and compositions |
JP6899043B2 (ja) | 2015-05-22 | 2021-07-07 | エージンバイオ, インコーポレイテッド | レベチラセタムの持続放出性医薬組成物 |
EP3439649B1 (de) | 2016-04-08 | 2023-11-15 | Cereno Scientific AB | Pharmazeutische formulierungen mit verzögerter freisetzung mit valproinsäure und verwendungen davon |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL32673A (en) * | 1968-08-05 | 1973-11-28 | Ciba Geigy Ag | A granular material containing oily or liquid therapeutically usable furanosides and a process for its manufacture |
US4301176A (en) * | 1980-08-18 | 1981-11-17 | Warner-Lambert Company | Method of administering calcium valproate |
NL8600050A (nl) * | 1986-01-13 | 1987-08-03 | Sanico Nv | Farmaceutisch preparaat met vertraagde afgifte van het werkzame bestanddeel en werkwijze voor de bereiding er van. |
-
1987
- 1987-10-23 DE DE8787810611T patent/DE3773926D1/de not_active Expired - Fee Related
- 1987-10-23 ES ES198787810611T patent/ES2026198T3/es not_active Expired - Lifetime
- 1987-10-23 EP EP87810611A patent/EP0300111B1/de not_active Expired
- 1987-10-23 AT AT87810611T patent/ATE68346T1/de not_active IP Right Cessation
-
1990
- 1990-05-02 US US07/517,620 patent/US5049586A/en not_active Expired - Fee Related
-
1991
- 1991-11-25 GR GR91401648T patent/GR3003187T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2026198T3 (es) | 1992-04-16 |
DE3773926D1 (de) | 1991-11-21 |
US5049586A (en) | 1991-09-17 |
EP0300111A1 (de) | 1989-01-25 |
GR3003187T3 (en) | 1993-02-17 |
EP0300111B1 (de) | 1991-10-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |