ATE68346T1 - Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung. - Google Patents

Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung.

Info

Publication number
ATE68346T1
ATE68346T1 AT87810611T AT87810611T ATE68346T1 AT E68346 T1 ATE68346 T1 AT E68346T1 AT 87810611 T AT87810611 T AT 87810611T AT 87810611 T AT87810611 T AT 87810611T AT E68346 T1 ATE68346 T1 AT E68346T1
Authority
AT
Austria
Prior art keywords
weight percent
valproic acid
moisture
stable solid
production
Prior art date
Application number
AT87810611T
Other languages
English (en)
Inventor
Aracelis M Dr Ortega
Perez Pilar Martin Dr De
Margarita De
Original Assignee
Farvalsa Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farvalsa Ag filed Critical Farvalsa Ag
Application granted granted Critical
Publication of ATE68346T1 publication Critical patent/ATE68346T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT87810611T 1987-07-22 1987-10-23 Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung. ATE68346T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7663487A 1987-07-22 1987-07-22
EP87810611A EP0300111B1 (de) 1987-07-22 1987-10-23 Feuchtigkeitsstabile feste Valproinsäure-Zubereitung und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ATE68346T1 true ATE68346T1 (de) 1991-11-15

Family

ID=22133265

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87810611T ATE68346T1 (de) 1987-07-22 1987-10-23 Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung.

Country Status (6)

Country Link
US (1) US5049586A (de)
EP (1) EP0300111B1 (de)
AT (1) ATE68346T1 (de)
DE (1) DE3773926D1 (de)
ES (1) ES2026198T3 (de)
GR (1) GR3003187T3 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR1002098B (en) * 1989-06-08 1995-12-28 Squibb & Sons Inc Pharmaceutical composition having good stability
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
PL169106B1 (pl) * 1991-01-30 1996-06-28 Wellcome Found Sposób wytwarzania dyspergowalnej w wodzie tabletki PL PL PL PL PL PL PL
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
ZA953078B (en) * 1994-04-28 1996-01-05 Alza Corp Effective therapy for epilepsies
US20040191314A1 (en) * 1994-04-28 2004-09-30 Frank Jao Antiepileptic dosage form and process for protecting antiepileptic drug
US5681854A (en) * 1995-11-22 1997-10-28 Alcon Laboratories, Inc. Use of aliphatic carboxylic acid derivatives in ophthalmic disorders
CN1063971C (zh) * 1997-09-24 2001-04-04 中国兽药监察所 一种动物用冻干活疫苗制造方法
US6300328B1 (en) 1999-08-06 2001-10-09 Alcon Universal Ltd. Selective inhibitors of adenosine monophosphate deaminase for the treatment of optic nerve and retinal damage
JP2003516962A (ja) * 1999-12-16 2003-05-20 アルコン，インコーポレイテッド 視神経損傷および網膜損傷の処置のためのアデノシンキナーゼのインヒビター
US20020143058A1 (en) 2001-01-24 2002-10-03 Taro Pharmaceutical Inductries Ltd. Process for preparing non-hygroscopic sodium valproate composition
US6610326B2 (en) 2001-02-16 2003-08-26 Andrx Corporation Divalproex sodium tablets
US20040105886A1 (en) * 2001-02-16 2004-06-03 Chih-Ming Chen Divalproex sodium tablets
CN1829804A (zh) 2002-11-22 2006-09-06 约翰斯·霍普金斯大学 治疗认知功能障碍的靶位
MXPA05005937A (es) 2002-12-06 2005-08-18 Alcon Inc Imitaciones de superoxido de dismutasa para el tratamiento de trastornos y enfermedades oculares.
US20040176463A1 (en) * 2003-02-05 2004-09-09 Daniella Licht Immediate release formulation of n-(2-propylpentanoyl)glycinamide
CN1889961A (zh) * 2003-12-11 2007-01-03 爱尔康公司 用于治疗视神经和视网膜损伤的超氧化物歧化酶拟似物
US7713550B2 (en) * 2004-06-15 2010-05-11 Andrx Corporation Controlled release sodium valproate formulation
US20050276849A1 (en) * 2004-06-15 2005-12-15 Nilobon Podhipleux Sustained release dosage forms
US20070048379A1 (en) * 2005-08-29 2007-03-01 Mintong Guo Valproate tablet
JP2009525953A (ja) * 2006-01-11 2009-07-16 テバ ファーマシューティカル インダストリーズ リミティド ジバルプロ酸及びその誘導体の徐放性製剤
US20070160667A1 (en) * 2006-01-11 2007-07-12 Nava Shterman Controlled release formulation of divalproex sodium
DE602006003848D1 (de) * 2006-01-11 2009-01-08 Teva Pharma Formulierung zur verzögerten Freisetzung von Valproinsäure und deren Derivate
WO2007101204A1 (en) * 2006-02-27 2007-09-07 Alcon Research, Ltd. Method of treating glaucoma
WO2008001151A1 (en) * 2006-06-29 2008-01-03 Wockhardt Limited Controlled release compositions of divalproex sodium
WO2009103336A1 (de) * 2008-02-20 2009-08-27 Boehringer Ingelheim International Gmbh Pulverinhalatoren
US20090235929A1 (en) * 2008-03-19 2009-09-24 Marc Egen Powder inhalers
EA033130B1 (ru) 2008-10-16 2019-08-30 Дзе Джонс Хопкинс Юниверсити Способы и композиции для улучшения когнитивной функции
US20110212928A1 (en) * 2010-02-09 2011-09-01 The Johns Hopkins University Methods and compositions for improving cognitive function
EP2919788A4 (de) 2012-11-14 2016-05-25 Univ Johns Hopkins Verfahren und zusammensetzungen zur behandlung von schizophrenie
ES2881081T3 (es) 2013-03-15 2021-11-26 Agenebio Inc Procedimientos y composiciones para mejorar la función cognitiva
US10806717B2 (en) 2013-03-15 2020-10-20 The Johns Hopkins University Methods and compositions for improving cognitive function
GB201417828D0 (en) 2014-10-08 2014-11-19 Cereno Scient Ab New methods and compositions
JP6899043B2 (ja) 2015-05-22 2021-07-07 エージンバイオ， インコーポレイテッド レベチラセタムの持続放出性医薬組成物
EP3439649B1 (de) 2016-04-08 2023-11-15 Cereno Scientific AB Pharmazeutische formulierungen mit verzögerter freisetzung mit valproinsäure und verwendungen davon

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL32673A (en) * 1968-08-05 1973-11-28 Ciba Geigy Ag A granular material containing oily or liquid therapeutically usable furanosides and a process for its manufacture
US4301176A (en) * 1980-08-18 1981-11-17 Warner-Lambert Company Method of administering calcium valproate
NL8600050A (nl) * 1986-01-13 1987-08-03 Sanico Nv Farmaceutisch preparaat met vertraagde afgifte van het werkzame bestanddeel en werkwijze voor de bereiding er van.

Also Published As

Publication number Publication date
ES2026198T3 (es) 1992-04-16
DE3773926D1 (de) 1991-11-21
US5049586A (en) 1991-09-17
EP0300111A1 (de) 1989-01-25
GR3003187T3 (en) 1993-02-17
EP0300111B1 (de) 1991-10-16

Similar Documents

Publication Publication Date Title
ATE68346T1 (de) Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung.
GB2143734B (en) Process for the preparation of sustained release pharmaceutical compositions having a high active ingredient content
ATE48943T1 (de) Feste arzneizubereitung enthaltend nitrendipin und verfahren zur ihrer herstellung.
HUT61989A (en) Process for producing 2-deoxy-2,3-didehydro-n-acetylneuraminic acid derivatives and analogs, as well as pharmaceutical compositions comprising same as active ingredient
HUT46531A (en) Process for producing retard tabletted pharmaceutical compositions
IL88615A (en) 1,7-annelated indolecarboxylic acid esters and carboxamides,their preparation and pharmaceutical compositions containing them
HUT51485A (en) Process for production of immune-hindering, monoquin, especially internuclein-1-hindering medical compositions
HUT47865A (en) Process for producing pharmaceutical compositions containing somatostatin as active component
GB1296505A (de)
HUT48597A (en) Process for producing pharmaceutical compositions comprising substituted 2-phenyl-4-quinolinecarboxylic acid derivatives and the new quinolinecarboxylic acid derivatives
AU1888488A (en) Substituted benzimidazoles, a process for the preparation thereof, pharmaceutical formulations containing them, and theuse thereof
HUT49053A (en) Process for producing pharmaceutical composition comprising comt inhibitor as active ingredient and having action on gastrointestinal tract
HUT49361A (en) Process for producing piperazinecarboxylic acid derivative and pharmaceutical compositions comprising this compound
HUT54166A (en) Process for producing 1,1-dioxocefem-4-carbothiol acid derivatives and pharmaceutical compositions comprising same as active ingredient
HUT47077A (en) Process for producing hydrocinnamomic acid derivatives and pharmaceutical compositions containing them as active components
DE59010710D1 (de) Modifizierte Stärke und Verfahren zu ihrer Herstellung
HUT50324A (en) Process for producing thiophene-2-carboxylic acid derivatives and pharmaceutical compositions comprising such compounds
IL87739A (en) Amino acid esters, a process for their preparation and pharmaceutical compositions containing them
ES8503511A1 (es) Medicamento que contiene muzolimina
EP0383481A3 (de) Bukkale Anästhetika
HUT48272A (en) Process for producing nukleinic acid derivatives and pharmaceutical compositions containing them
HUT49275A (en) Insecticides and acaricides comprising bicyclooctane derivatives as active ingredient and process for producing such compounds and their intermediaries
HUT49604A (en) Process for producing guanidinecarboxylic acid esters and pharmaceutical compositions comprising same
HUT45841A (en) Herbicidal compositions comprising 3-amino-2-cyano-acrylic acid ester derivatives as active ingredient and process for producing the active ingredient
GB2009177A (en) Amino-and guanidino -1,2,3,4 - tetrahydro -unaphtoic acid esters process for their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee